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Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury 认领 引用
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作者 Zhongze Yuan Lusen Shi +15 位作者 Xiao-Na Tao Xiangchuang Fan Han Zheng Yifan Shang Xiaoqing Zhao Fan Yang Hui Lin Peng Xiao Bo Chu Jichuan Qiu Shaohui Zong Ning Ran Xiaohong Kong Jin-Peng Sun Hengxing Zhou Shiqing Feng 《Bone Research》 SCIE CAS CSCD 2026年第1期62-81,共20页
Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial re... Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial research has reported the therapeutic potential of Omega-3 fatty acids for the central nervous system,particularly after traumatic SCI.Omega-3 fatty acids may contribute to improving SCI recovery through their anti-inflammatory,anti-oxidative,neurotrophic,and membrane integrity-preserving properties.These functions of Omega-3 fatty acids are primarily mediated via the activation of G protein-coupled receptor 120(GPR120),commonly known as the fish oil-specific receptor.Advancements in understanding of the molecular mechanisms of GPR120’s recognition of Omega-3 fatty acids and its downstream signaling mechanisms has significantly promoted research on the pharmacological potential of Omega-3 fatty acids and the development of highly selective and high-affinity alternatives.This review aims to provide in-depth analysis of the comprehensive therapeutic potential of Omega-3 fatty acids for SCI and its accompanying complications,and the prospects for developing novel drugs based on the recognition of Omega-3 fatty acids by GPR120. 展开更多
关键词 central nervous systemparticularly impairment neural circuitsleading spinal cord injury traumatic spinal cord injury omega fatty acids sensory functions traumatic spinal cord injury sci neural circuits
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Orthogonal Stimulus-Responsive Ca3Ga2Ge3O12:Pr3+for Real-Time X-Ray Dosimetry and Dynamic Information Encryption 认领 引用
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作者 Qi Chen Wenqiang Wang +8 位作者 Ping Liu Weifang Bu Yang Yue Yifan Shang Feixiang Xiong Ting Wang Xiangke Niu Zhiqiang Li Xue Yu 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期422-429,共8页
Multimodal luminescent materials are crucial for advanced information encryption,real-time dosimetry,and high-resolution bioimaging,yet integrating orthogonal stimulus-responsiveness into a single-component system is ... Multimodal luminescent materials are crucial for advanced information encryption,real-time dosimetry,and high-resolution bioimaging,yet integrating orthogonal stimulus-responsiveness into a single-component system is challenging.Herein,we report a Pr3+-doped Ca3Ga2Ge3O12(CGGO:Pr3+)garnet phosphor that exhibits orthogonally addressable luminescence under ultraviolet(UV)light,X-ray radiation,and thermal stimulation.This phosphor demonstrates dual spectrally distinct emissions with relative intensities that can be precisely modulated by varying the excitation wavelength or ambient temperature,enabling color tuning from blue to orange.Furthermore,time-resolved multi-color afterglow after UV or X-ray pre-excitation,along with thermally stimulated luminescence,provides complementary readout channels.Notably,CGGO:Pr3+exhibits dose-rate-and temperature-dependent color evolution(from blue-white to orange-white)under concurrent UV and X-ray irradiation,facilitating real-time naked-eye monitoring of both X-ray dose rate and temperature.By leveraging these orthogonal response modes,we demonstrate visual real-time X-ray dose and temperature detection,high-security X-ray imaging,and 3D-encrypted quick response codes.This study establishes CGGO:Pr3+as a versatile single-component platform for orthogonal stimuli-responsive applications,advancing the fields of dynamic information encryption and instantaneous X-ray dose-rate visualization. 展开更多
关键词 dynamic information encryption orthogonal stimulus-responsiveness X-ray dosimetry
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非鳞状免疫表型鼻咽癌23例临床病理学分析 认领 引用 被引量：2
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作者 王佳鹤 祝昊 +5 位作者 尚轶钒 王玉姣 李烨 王蕾 黄思夏 吕新全 《中华病理学杂志》 CAS CSCD 北大核心 2022年第6期500-505,共6页
目的探讨非鳞状免疫表型鼻咽癌(NSNPC)的病理分型及其临床病理特征。方法收集郑州大学第一附属医院2011至2019年经病理确诊为NSNPC的病例, 应用HE及免疫组织化学染色、原位杂交、透射电镜及聚合酶链反应(PCR)分析其病理学特点, 并收集... 目的探讨非鳞状免疫表型鼻咽癌(NSNPC)的病理分型及其临床病理特征。方法收集郑州大学第一附属医院2011至2019年经病理确诊为NSNPC的病例, 应用HE及免疫组织化学染色、原位杂交、透射电镜及聚合酶链反应(PCR)分析其病理学特点, 并收集临床随访资料。结果 (1)23例NSNPC中男性14例, 女性9例, 年龄范围16~76岁, 中位年龄46岁, 平均年龄为45岁。(2)形态学上均与经典鼻咽癌镜下形态相似。(3)免疫组织化学结果:NSNPC多表达低分子质量细胞角蛋白(CK8/18、CK8、CKL), 与经典鼻咽癌组比较, 差异具有统计学意义(P0.05)。(4)病原学检测:EBER阳性率78.3%(18/23), HPV阳性率8.7%(2/23), 分别为HPV35及HPV38型。(5)基因改变:相较于经典鼻咽癌, 抑癌基因BLU在NSNPC组织中表达增强;抑癌基因RASSF1及Rbms3在NSNPC组织中表达减弱, 与经典鼻咽癌表达一致。(6)超微结构特征:5例中发现细胞之间有桥粒连接, 余18例未见明显桥粒连接。(7)分期及预后:NSNPC与经典鼻咽癌相比, NSNPC复发率低、临床分期较早(P0.05)。结论 NSNPC在组织学形态、病原学及基因改变上均与经典鼻咽癌类似, NSNPC仍属于非角化鳞癌中的未分化型。NSNPC恶性程度较低, 预后较好。 展开更多
关键词 鼻咽肿瘤 病理学 临床 免疫组织化学 预后
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