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Anti-inflammatory and Bone Regenerative Efficacy of Diflunisal-Loaded 3D-Printed Scaffolds in Treating Osteomyelitis 认领 引用
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作者 Jiehui Yang Li Chen +10 位作者 Mao Yang Ke Zeng Chenxin Wang Rui Zhang Mingyue Lin Huanshuo Zhang Denglang Hu Min Huang Yubao Li Yijing Stehle Qin Zou 《Journal of Bionic Engineering》 SCIE EI CSCD 2026年第2期977-991,共15页
Osteomyelitis caused by Staphylococcus aureus(S.aureus)is a severe inflammatory bone disease that is difficult to eradicate and can be life-threatening.Traditional treatments relying on high-dose systemic antibiotics ... Osteomyelitis caused by Staphylococcus aureus(S.aureus)is a severe inflammatory bone disease that is difficult to eradicate and can be life-threatening.Traditional treatments relying on high-dose systemic antibiotics often fail due to biofilm resistance and emerging drug-resistant strains.This study proposes a diflunisal-loaded 3D-printed scaffold as a novel therapeutic strategy.A composite biomaterial ink composed of gelatin(Gel),polycaprolactone(PCL),and nanohydroxyapatite(n-HA)was synthesized and used to fabricate customized porous scaffolds via 3D printing.Diflunisal was loaded onto the scaffolds using a Gel swelling method.In vitro experiments showed sustained diflunisal release under different pH conditions(pH=6.0 and 7.4)mimicking infection and protection of bone marrow stromal cells(BMSCs)from S.aureus toxins.In vivo studies revealed significant alleviation of infection and promotion of bone regeneration at the defect site.This diflunisal-loaded Gel/PCL-HA scaffold integrates anti-virulence therapy with bone regeneration,offering a promising solution for osteomyelitis treatment. 展开更多
关键词 Osteomyelitis Staphylococcus aureus Diflunisal-loaded scaffold 3D printing Bone regeneration Anti-virulence therapy
Extrusion-base d 3D-printe d“rolle d-up”composite scaffolds with hierarchical pore structure for bone growth and repair 认领 引用 被引量：3
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作者 Yufan Li Li Chen +6 位作者 Yijing Stehle Mingyue Lin Chenxin Wang Rui Zhang Min Huang Yubao Li Qin Zou 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第4期222-234,共13页
Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bon... Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue engineering.However,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone growth.Therefore,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility performance.Herein,patterned polylactic acid(PLA)/polycaprolactone(PCL)ano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair experiment.The result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair. 展开更多
关键词 Direct ink writing(DIW) Bone repair scaffold,Micro-CT Bio composites
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Polycaprolactone strengthening gelatin/nano-hydroxyapatite composite biomaterial inks for potential application in extrusion-based 3D printing bone scaffolds 认领 引用 被引量：1
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作者 Chenxin Wang Mao Yang +8 位作者 Li Chen Yijing Stehle Mingyue Lin Rui Zhang Huanshuo Zhang Jiehui Yang Min Huang Yubao Li Qin Zou 《Collagen and Leather》 EI CAS 2024年第3期119-140,共22页
Extrusion-based three-dimensional(3D) printing of gelatin(Gel) is crucial for fabricating bone tissue engineering scaffolds via additive manufacturing. However, the thermal instability of Gel remains a persistent chal... Extrusion-based three-dimensional(3D) printing of gelatin(Gel) is crucial for fabricating bone tissue engineering scaffolds via additive manufacturing. However, the thermal instability of Gel remains a persistent challenge, as it tends to collapse at mild temperatures. Current approaches often involve simply mixing Gel particles with various materials, resulting in biomaterial inks that lack uniformity and have inconsistent degradation characteristics. In this study, acetic acid was used to dissolve Gel and polycaprolactone(PCL) separately, producing homogeneous Gel/PCL dispersions with optimal pre-treatment performance. These dispersions were then combined and hybridized with nano-hydroxyapatite(n-HA) to create a composite printing ink. By evaluating the printability of the ink, the optimal conditions were identified: a n-HA concentration of 50%(w/w), a printing temperature of 10–15 ℃, a printing pressure of 2.5 bar, and a printing speed of 7 mm/s. The resulting biomaterial inks, with a composition of 25% Gel, 25% PCL, and 50% n-HA, demonstrated excellent printability and stability, along with significantly enhanced mechanical properties. As a result, 3D scaffolds with high printability and shape fidelity can be printed at room temperature, followed by deep freezing at-80 ℃ and cross-linking with vanillin. The Gel-based composite scaffolds demonstrated excellent biocompatibility, cell adhesion, cell viability and nano-hydroxyapatite absorption in vitro. Additionally, in vivo experiments revealed that the bioactive scaffold biodegraded during implantation and significantly promoted bone regeneration at the defect site. This provides a promising strategy for treating bone defects in clinical setting. In conclusion, the Gel/PCL-HA biomaterial inks presented here offer an innovative solution for extrusion bioprinting in the field of bone tissue engineering. 展开更多
关键词 Gelatin Nano-hydroxyapatite Polycaprolactone Polymer-matrix composites scaffold(PMCs) Bone regeneration
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