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Seasonal climate effect on organ proportion and morbidity in 'Bi-zheng' rats with kidney deficiency syndrome 认领 引用 被引量：1
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作者 Cai Wang Yilan Wang +5 位作者 Tong Wang Dahong Ju Hongyan Zhao Ya Gao Dallas Tokash Ning Zhang 《Journal of Traditional Chinese Medical Sciences》 CAS 2019年第1期75-83,共9页
Objective:Using the traditional Chinese medicine theory of 'Bi-zheng' caused by kidney deficiency,combined with modern medical science and technology,this study assessed the relationships among organ weight,cy... Objective:Using the traditional Chinese medicine theory of 'Bi-zheng' caused by kidney deficiency,combined with modern medical science and technology,this study assessed the relationships among organ weight,cytokines,pathological manifestations,and traditional Chinese medicine kidney deficiency syndrome in rats with rheumatoid arthritis.Methods:Sixty Sprague-Dawley rats were randomly divided into normal,collagen-induced arthritis (ClA) model,and kidney deficiency arthralgia model groups.Rats in the kidney deficiency arthritis group underwent removal of the testis or ovary and administration of an inflammatory agent.Rats in the control group solely received an inflammatory agent.Type Ⅱ collagen-induced arthritis was induced within 1 week of the winter solstice or summer solstice,in order to sample organs and observe the mental state,posture,fur color,activity level,excrement,body weight,and organ weight of the rats.Results:Compared with the normal and CIA model groups,the kidney deficiency arthralgia model group showed fast and acute onset,prominent symptoms,most obvious potential joint swelling,worst general state,and least amount of weight gain.Compared with the normal group,the proportion of thymus,spleen,and adrenal glands of model rats were larger in winter,with varying degrees of hyperplasia and hypertrophy;these differences were statistically significant (P <.05).In summer,model coefficients were greater than normal in the spleen,while the thymus and adrenal gland coefficients were significantly different between the normal and kidney deficiency arthralgia groups.In summer,the thymus in the kidney deficiency arthralgia group exhibited hypertrophy and hyperplasia,whereas the thymus in the control group did not;this difference was statistically significant (P =.015).Thymus and adrenal gland proportions exhibited seasonal differences in CIA model rats;these were statistically significant (P <.05),with high performance in winter and low performance in summer.The spleen proportion exhibited a trend of high performance in winter and low performance in summer in the kidney deficiency arthralgia model rats.Conclusion:Kidney deficiency is an internal condition linked with the occurrence of arthralgia,and seasonal factors exhibit an impact on the morbidity of arthritis in rats. 展开更多
关键词 Seasonal correlation Kidney deficiency Arthralgia Rats
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Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate 认领 引用
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作者 Pei Cao Yilan Wang +3 位作者 Lejian Yu Miao Wang Liming Zhao Xu Hou 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第6期249-253,共5页
Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic circuits.Nevertheless,the creation of biomimetic asymmetric ion channels nec... Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic circuits.Nevertheless,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic devices.In this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical stress.We have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits. 展开更多
关键词 Carbon nanotubes fibers Mechanical response Rectification effect Ionic logic gate
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Fabrication of TiO_2(B)/anatase heterophase junctions in nanowires via a surface-preferred phase transformation process for enhanced photocatalytic activity 认领 引用 被引量：5
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作者 Yilan Wang Wan Zhang +4 位作者 Zihao Wang Yimeng Cao Jiami Feng Zenglin Wang Yi Ma 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2018年第9期1500-1510,共11页
Heterojunction fabrication is one of the most effective strategies for enhancing the photocatalytic performance of semiconductor photocatalysts. Here, TiO2（B）/anatase nanowires with interfacial heterostructures were... Heterojunction fabrication is one of the most effective strategies for enhancing the photocatalytic performance of semiconductor photocatalysts. Here, TiO2（B）/anatase nanowires with interfacial heterostructures were prepared through a three-step synthesis method, including hydrothermal treatment, H＋ exchange, and annealing. The phase structures of the nanowires in the bulk and on the surface during the annealing process were monitored by XRD and UV-Raman spectroscopy, respectively. SEM and TEM results indicate that the TiO2（B） nanowires partially collapse and transform into anatase during the annealing process and the heterophase junction structure is formed simultaneously. On the basis of the phase structure together with morphology data, a phase-transformation mechanism was proposed. Photocatalytic activity was evaluated by hydrogen production and pollutant-degradation assays. The optimized structure of the photocatalyst contains 24% TiO2（B） in the bulk and 100% anatase on the surface. The charge-carrier behavior during the photocatalytic process was investigated by photocurrent, electrochemical impedance spectroscopy（EIS）, and photoluminescence（PL） spectroscopy, which revealed that the heterophase-junction structure in the bulk was responsible for the highly efficient charge separation and transportation, etc.; the anatase on the surface took control of the high surface-reaction activity. 展开更多
关键词 TiO2（B）/anatase Heterophase junction Surface‐preferred Photocatalysis Phasetransformation
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Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B:A Prospective Trial 认领 引用
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作者 Min Liu Lili Zuo +8 位作者 Yuting Zhang Bing Bu An Xiao Ling Zhu Xiuying Ma Yilan Wang Wei Yue Jiawei Geng Xueshan Xia 《Journal of Clinical and Translational Hepatology》 SCIE CSCD 2026年第4期452-461,共10页
Background and Aims:The optimal management strategy for adults with immune-tolerant(IT)chronic hepatitis B infection remains undefined.This study aimed to investigate the efficacy and predictive factors of a pegylated... Background and Aims:The optimal management strategy for adults with immune-tolerant(IT)chronic hepatitis B infection remains undefined.This study aimed to investigate the efficacy and predictive factors of a pegylated interferon(Peg-IFN)-based treatment strategy in IT patients with chronic HBV infection.Methods:In this pilot,open-label,prospective study,286 patients aged 18 to 60 years with IT characteristics were enrolled and allocated to one of three groups.The combination group received Peg-IFN for 48–96 weeks,with tenofovir disoproxil fumarate(TDF)initiated at week 12 and continued through week 96(n=103).The monotherapy group received TDF monotherapy alone(n=125),and the control group was monitored without therapeutic intervention(n=58).Results:No patients in the control group met any predefined efficacy endpoints.Intention-to-treat analysis showed that patients in the combination group achieved significantly higher virological response rates(71.8%vs.53.6%,p=0.005),hepatitis B e antigen seroconversion rates(15.5%vs.1.6%,p<0.001),and hepatitis B surface antigen(HBsAg)loss rates(10.7%vs.0%,p<0.001)compared with those in the monotherapy group at week 96.In the combination group,the cumulative rate of HBsAg loss was 5.4%at week 48 and increased to 11.8%by week 96.Independent predictors of achieving either hepatitis B e antigen seroconversion or HBsAg loss were baseline age under 30 years(odds ratio=0.217,95%confidence interval:0.048–0.976,p=0.046)and a decline in HBsAg level greater than 1 log10 IU/mL by week 24(odds ratio=13.976,95%confidence interval:2.506–77.932,p=0.003).Conclusions:A Peg-IFN-based treatment strategy significantly increases response rates compared with TDF monotherapy or observation in patients with IT characteristics. 展开更多
关键词 Hepatitis B,Chronic Immune tolerance Pegylated interferon Tenofovir disoproxil fumarate Antiviral therapy Prospective Studies
Bioinspired nanofluidic iontronics for brain-like computing 认领 引用 被引量：5
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作者 Lejian Yu Xipeng Li +5 位作者 Chunyi Luo Zhenkang Lei Yilan Wang Yaqi Hou Miao Wang Xu Hou 《Nano Research》 SCIE EI CSCD 2024年第2期503-514,共12页
The human brain performs computations via a highly interconnected network of neurons.Taking inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired ... The human brain performs computations via a highly interconnected network of neurons.Taking inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like computing.Anomalous and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like functions.Herein,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic iontronics.This review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions devices.Furthermore,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons. 展开更多
关键词 human brain ion transport nanofluidics brain-like computing memristive effect
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