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Self-assembled polyoxometalate-phenolic nanodrugs integrated with dissolving microneedles for hypertrophic scar combination therapy 认领 引用
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作者 Manyi Du Ruofei Xu +6 位作者 Xianbin Sun Haixin Long Jing Yu Yilin Zheng Haijun Chen Yansheng Lin Yu Gao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2026年第2期318-334,I0007-I0027,共17页
The clinical management of hypertrophic scars(HSs)remains challenging due to their complex etiology and heterogeneous morphology,underscoring the need for multitarget treatment strategies.In this study,we developed a ... The clinical management of hypertrophic scars(HSs)remains challenging due to their complex etiology and heterogeneous morphology,underscoring the need for multitarget treatment strategies.In this study,we developed a nanocomposite system constructed through the metal-phenolic network-mediated self-assembly of molybdenum polyoxometalate({Mo 154})and epigallocatechin gallate(EGCG),followed by chitosan encapsulation,to generate chitosan-encapsulated{Mo 154}/EGCG(CME)nanoparticles.These nanoparticles were integrated into dissolvable microneedles(CME@MN)to enable transdermal administration.Under near-infrared laser irradiation,CME exhibited a three-pronged therapeutic effect:suppression of collagen overproduction and excessive extracellular matrix(ECM)deposition in human keloid fibroblasts,regulation of proliferation and migration in human umbilical vein endothelial cells,and reprogramming of macrophages toward a proinflammatory M1 phenotype.In vivo,CME@MN patches preferentially accumulated within scar tissue,where they normalized ECM organization,improved collagen fiber rearrangement,and attenuated fibroblast activity through photothermal-enhanced mechanisms while maintaining an excellent safety profile.The CME@MN system represents a potentially transformative approach to HS management by offering a unified platform that simultaneously targets the fibrotic,angiogenic,and inflammatory components of scar pathogenesis. 展开更多
关键词 Hypertrophic scar therapy Anti-fibrosis Microneedle Metal-phenolic network Polyoxometalate
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Preliminary study on the depositional model in the wavedominated delta evolution during the Anthropocene:a case study of the Hanjiang River Delta in China 认领 引用 被引量：1
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作者 Hongyue Wang Zhongbo Wang +8 位作者 Yang Wang Haiyan Tang Xiaodong Zhang Xiaofeng Luo Yongxin Mai Xuhong Huang Yilin Zheng Ping Yin Zhongping Lai 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第11期45-56,共12页
The deltas serve as the primary interactive zone where terrestrial and marine environments converge,playing a pivotal role in the coastal deposition.In the Holocene,climate changes and sea level fluctuation are the pr... The deltas serve as the primary interactive zone where terrestrial and marine environments converge,playing a pivotal role in the coastal deposition.In the Holocene,climate changes and sea level fluctuation are the principal driving factors in the evolution of deltas.However,human activities such as the construction of dams and reservoirs in the Anthropocene have significantly altered sediment transport in rivers,leading to depositional pattern variation during deltaic evolution.In this study,we have conducted a comparative analysis of the morphological variations(1986-2021)in the barrier system of the Hanjiang River Delta(HRD)using satellite remote sensing(SRS)method.Additionally,we have examined the lithological changes and facies alterations observed in eight boreholes on the present barrier spit.Our findings indicate that the intensification of anthropogenic activities led to a significant reduction in the sediment flux of the Hanjiang River(HR),resulting in depocenter landward migration at the estuary.SRS analysis reveals their periodical morphological characteristics and spatial variations of estuarine sandbars(1986-1992),barrier islands-lagoons(1993-2009),and barrier spits(2010-2021)during 1986 to 2021.The stratigraphy of boreholes demonstrates a south-to-north facies transition from lagoon to lagoon-barrier spit and barrier spit in vertical lithology.Therefore,the depositional evolution of the HRD barrier system is categorized into three phases:estuarine sandbar-barrier island phase(1986-1998);barrier island-lagoon phase(1999-2009);and barrier spit phase(2010-2021).During the estuarine sandbar-barrier island phase,fluvial processes played a predominate role in the deposition.Consequently,with a significant decrease in river sediment load,the dominant factors driving depositional processes shifted towards wave action and alongshore current.Based on the conceptual model in the Holocene,we propose a modified depositional model of wave-dominated deltas during Anthropocene that encompasses three evolutionary phases:estuarine sandbars and delta front platforms,barrier island-lagoon formation and landward migration of barrier spits.This pattern highlights that human-induced reduction in river sediment flux has led to a seaward deltaic progradation driven by barrier landward migration. 展开更多
关键词 Hanjiang River Delta barrier spit human activities wave-dominated delta depositional model
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The Low-Attenuation Endfire Leaky-Wave State on an Optically Transparent Lossy Film 认领 引用 被引量：1
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作者 Ziheng Zhou Yongjian Zhang +6 位作者 Yilin Zheng Ke Chen Yueming Gao Yuehe Ge Yue Li Yijun Feng ZhizhangChen 《Engineering》 SCIE EI CAS CSCD 2024年第12期72-80,共9页
The development of high-performance optically transparent radio frequency(RF)radiators is limited by the intrinsic loss issue of transparent conductive films(TCFs).Instead of pursuing expensive endeavors to improve th... The development of high-performance optically transparent radio frequency(RF)radiators is limited by the intrinsic loss issue of transparent conductive films(TCFs).Instead of pursuing expensive endeavors to improve the TCFs'electrical properties,this study introduces an innovative approach that leverages leaky-wave mode manipulation to mitigate the TCFs'attenuating effect and maximize the RF radiation.Our finding reveals that the precise control of the mode confinement on glass-coated TCFs can create a low-attenuation window for leaky-wave propagation,where the total attenuation caused by TCF dissipation and wave leakage is effectively reduced.The observed low-attenuation leaky-wave state on lossy TCFs originates from the delicate balance between wave leakage and TCF dissipation,attained at a particular glass cladding thickness.By leveraging the substantially extended radiation aperture achieved under suppressed wave attenuation,this study develops an optically transparent antenna with an enhanced endfire realized gain exceeding 15 dBi and a radiation efficiency of 66%,which is validated to offer competitive transmission performance for advancing ubiquitous wireless communication and sensing applications. 展开更多
关键词 Antennas Endfire radiation Low attenuation Material losses Transparent conductive films
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Molten hydroxide for detoxification of chlorine-containing waste: Unraveling chlorine retention efficiency and chlorine salt enrichment 认领 引用 被引量：4
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作者 Shijin Dai Yilin Zheng +2 位作者 Youcai Zhao Yu Chen Dongjie Niu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第8期192-202,共11页
Hazardous waste dechlorination reduces the potential of creating dioxins during the incineration process. To investigate the salt effect on waste dechlorination, molten hydroxides with a low melting temperature were u... Hazardous waste dechlorination reduces the potential of creating dioxins during the incineration process. To investigate the salt effect on waste dechlorination, molten hydroxides with a low melting temperature were utilized for the pre-dechlorination and decomposition of chlorine-containing organic wastes(COWs) including trichlorobenzene(TCB),perchloroethylene, hexachlorobenzene and chlordane. The results showed that a eutectic mixture of caustic sodium and potassium hydroxides(41 wt.% NaOH and 59 wt.% KOH) led to a low melting point below 300°C and a relatively high chlorine retention efficiency(CRE) with TCB as a representative COWs. The amounts of hydroxides, reaction time, and temperature all had notable influence on CRE. When the mass ratio of hydroxides to TCB reached 30:1,approximately 98.1% of the TCB was destroyed within 2.5 hr at 300°C with CRE of 71.6%.According to the residue analysis, the shapes of reaction residues were irregular with particles becoming swollen and porous. The benzene ring and C–Cl bonds disappeared, while carboxyl groups formed in the residues. The stripped chlorine was retained and condensed to form chloride salts, and the relative abundance of the chloride ions associated with the mass of TCB in residues increased from 0 to 75.0% within the 2.5 hr reaction time. The observed concentration of dioxins in residues was 5.6 ngTEQ/kg. A reaction pathway and possible additional reactions that occur in this dechlorination system were proposed. Oxidizing agents may attack TCB and facilitate hydrogenation/dechlorination reactions, making this process a promising and environmentally friendly approach for chlorine-containing organic waste treatment. 展开更多
关键词 Molten salt Chlorine-containing organic waste Trichlorobenzene Pesticides Chlorine removal Chlorine salt
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Design and synthesis of novel α-aminoamides derivatives as Nav1.7 inhibitors for antinociception 认领 引用
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作者 Dengqi Xue Yani Liu +8 位作者 Yilin Zheng Heling Niu Liying Dong Xiangshuo Ouyang Siyu Song Denggao Zhang Qianwei Ge Kewei Wang Liming Shao 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第3期1643-1646,共4页
Three novel series of α-aminoamides derivatives were designed and synthesized based on ralfinamide,and their Nav1.7 inhibitory activities were evaluated using manual patch clamp electrophysiology. Active compounds in... Three novel series of α-aminoamides derivatives were designed and synthesized based on ralfinamide,and their Nav1.7 inhibitory activities were evaluated using manual patch clamp electrophysiology. Active compounds inhibited Nav1.7 with half maximal inhibitory concentration(IC50) values ranging from2.9 μmol/L to 21.4 μmol/L. Among them, the most potent compound 19h exhibited about 12-fold potency better than ralfinamide. The investigation of their structure-activity relationship gives a strategy to improve the Nav1.7 inhibition of ralfinamide analogues. Compound 19h was efficacious in antinociception in the mouse spared nerve injury(SNI) model of neuropathic pain without causing sedation in the open field test. 展开更多
关键词 α-Aminoamides Sodium channel Nav1.7 inhibitor Chronic pain Analgesia
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Interface mechanics of heterogenous integration and its applications 认领 引用
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作者 Yaqi Zhu Ruimin Zhang +2 位作者 Yilin Zheng Jiayi Wen Zhigong Song 《International Journal of Smart and Nano Materials》 SCIE EI 2026年第1期229-273,共45页
As the semiconductor industry approaches the limits of traditional scaling,heterogeneous bonding technology has become a key enabler for the‘More Moore’and‘More than Moore’strategies.This paper provides a systemat... As the semiconductor industry approaches the limits of traditional scaling,heterogeneous bonding technology has become a key enabler for the‘More Moore’and‘More than Moore’strategies.This paper provides a systematic review of the interface mechanics principles of heterogeneous bonding,with a focus on thermodynamic and shell mechanics theories.The paper explores how factors such as wettability,surface roughness,and flatness affect the physical adsorption behavior of bonding interfaces,and analyzes the surface chemical conditions required for the formation of stable covalent and metallic bonds.By integrating multiple materials,heterogeneous bonding overcomes the limitations of traditional single-chip integration systems,opening up new possibilities for high-performance,multifunctional semiconductor devices.This technology has significant applications in areas such as 3D integration,power electronics,photonics,and AI chip development.The paper also reviews the specific applications of metallic bonding,covalent bonding,and van der Waals bonding in heterogeneous integration.Ultimately,heterogeneous bonding is expected to drive the next wave of innovation in semiconductor technology,laying the foundation for more integrated and energy-efficient solutions for complex electronic systems. 展开更多
关键词 Heterogeneous bonding Moore’s Law physical adsorption chemical bonding interface mechanics
Recent progress in sono-photodynamic cancer therapy:From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies 认领 引用 被引量：20
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作者 Yilin Zheng Jinxiang Ye +2 位作者 Ziying Li Haijun Chen Yu Gao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第8期2197-2219,共23页
Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sonophotodynamic therapy(SPDT)pr... Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sonophotodynamic therapy(SPDT)provides alternative opportunities for clinical cancer therapy.Although significant advances have been made in synthesizing new sensitizers for SPDT,few of them are successfully applied in clinical settings.The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting specificity,incapability in deep intratumoral delivery,and the deteriorating tumor microenvironment.The application of nanotechnology-based drug delivery systems(NDDSs)can solve the above shortcomings,thereby improving the SPDT efficacy.This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT,and describes different strategies for enhancing tumor treatment by NDDSs,such as overcoming biological barriers,improving tumor-targeted delivery and intratumoral delivery,providing stimuli-responsive controlled-release characteristics,stimulating anti-tumor immunity,increasing oxygen supply,employing different therapeutic modalities,and combining diagnosis and treatment.The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also discussed. 展开更多
关键词 Sensitizers Sonodynamic therapy Photodynamic therapy Sono-photodynamic therapy Nanoparticles Drug delivery Cancer Efficacy-enhancing strategies
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Minimizing endogenous cryptic plasmids to construct antibiotic-free expression systems for Escherichia coli Nissle 1917 认领 引用 被引量：6
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作者 Siyan Zhou Linlin Zhao +6 位作者 Wenjie Zuo Yilin Zheng Ping Zhang Yanan Sun Yang Wang Guocheng Du Zhen Kang 《Synthetic and Systems Biotechnology》 SCIE CSCD 2024年第1期165-175,共11页
The probiotic bacterium Escherichia coli Nissle 1917(EcN)holds significant promise for use in clinical and biological industries.However,the reliance on antibiotics to maintain plasmid-borne genes has overshadowed its... The probiotic bacterium Escherichia coli Nissle 1917(EcN)holds significant promise for use in clinical and biological industries.However,the reliance on antibiotics to maintain plasmid-borne genes has overshadowed its benefits.In this study,we addressed this issue by engineering the endogenous cryptic plasmids pMUT1 and pMUT2.The non-essential elements were removed to create more stable derivatives pMUT1NR△and pMUT2HBC△.Synthetic promoters by integrating binding motifs on sigma factors were further constructed and applied for expression of Bacteroides thetaiotaomicron heparinaseⅢand the biosynthesis of ectoine.Compared to traditional antibiotic-dependent expression systems,our newly constructed antibiotic-free expression systems offer considerable advantages for clinical and synthetic biology applications. 展开更多
关键词 Cryptic plasmids Antibiotic-free Gene expression Plasmid stability E.coli Nissle 1917
Reconfigurable Intelligent Surfaces: Design, Implementation, and Practical Demonstration 认领 引用 被引量：13
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作者 Yijun Feng Qi Hu +3 位作者 Kai Qu Weixu Yang Yilin Zheng Ke Chen 《Electromagnetic Science》 2023年第2期17-37,共21页
Metasurfaces,ultrathin two-dimensional version of metamaterials,have attracted tremendous attention due to their exotic capabilities to freely manipulate electromagnetic waves.By incorporating various tunable material... Metasurfaces,ultrathin two-dimensional version of metamaterials,have attracted tremendous attention due to their exotic capabilities to freely manipulate electromagnetic waves.By incorporating various tunable materials or elements into metasurface designs,reconfigurable metasurfaces and related metadevices with functionalities controlled by external stimuli can be realized,opening a new avenue to achieving dynamic manipulation of electromagnetic waves.Recently,based on the tunable metasurface concept,reconfigurable intelligent surfaces(RISs)have received significant attention and have been regarded as a promising emerging technology for future wireless communication due to their potential to enhance the capacity and coverage of wireless networks by smartly reconfiguring the wireless propagation environment.Here,in this article,we first focus on technical issues of RIS system implementation by reviewing the existing research contributions,paying special attention to designs in the microwave regime.Then,we showcase our recent attempts to practically demonstrate RIS systems in real-world applications,including deploying reflective RIS systems in indoor scenarios to enhance the wireless network coverage and utilizing intelligent omni-metasurfaces to improve both indoor and through-wall wireless communication quality.Finally,we give our own perspectives on possible future directions and existing challenges for RISs toward a truly commercial intelligent technology platform. 展开更多
关键词 Reconfigurable intelligent surface Metasurface Wireless communication
媒体监督对高管薪酬结构的影响——基于大股东掏空的视角 认领 引用 被引量：4
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作者 黄志忠 郑依林 赵文妍 《当代会计评论》 2020年第2期35-56,共22页
本文从一个新的视角——大小股东利益冲突的角度分析了媒体的监督对高管薪酬结构的影响。已有文献表明,大股东掏空行为会损害中小股东和高管利益,使高管薪酬偏低且对业绩不敏感。本文的研究发现,媒体对大股东掏空行为的监督,会缓解大股... 本文从一个新的视角——大小股东利益冲突的角度分析了媒体的监督对高管薪酬结构的影响。已有文献表明,大股东掏空行为会损害中小股东和高管利益,使高管薪酬偏低且对业绩不敏感。本文的研究发现,媒体对大股东掏空行为的监督,会缓解大股东侵害中小股东的问题及管理层的代理问题,从而提高高管的固定薪酬和高管薪酬对业绩的敏感性。媒体报道对大股东自利行为的治理效应在大股东掏空动机较强的非国有控股上市公司和第一大股东持股比例在20%~50%的非国有控股上市公司中更加明显——该类公司受到媒体持续高强度曝光后,高管薪酬对业绩的敏感性会得到显著的提高;高管的固定薪酬在总体上也得到显著的提高。本文的研究表明,媒体高频率曝光对大股东自利行为和管理层的代理问题都具有治理效果。 展开更多
关键词 媒体监督 大股东掏空 薪酬结构 薪酬—业绩敏感性
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