Groundwater storage(GWS)is essential for supporting agricultural irrigation and revegetation in the water scarce Yellow River Basin(YRB).Early studies have mainly focused on the impacts of revegetation on GWS,and rare...Groundwater storage(GWS)is essential for supporting agricultural irrigation and revegetation in the water scarce Yellow River Basin(YRB).Early studies have mainly focused on the impacts of revegetation on GWS,and rarely consider the influences of agricultural irrigation and other human activities,rendering the driving mechanisms of GWS unclear.Here we used NASA’s Gravity Recovery and Climate Experiment(GRACE)satellite data,the PCR-GLOBWB2 hydrologic model,and an Long Short-Term Memory(LSTM)machine learning approach to reveal changes,driving mechanisms,and future trends in GWS in the YRB.Results show that GWS in the YRB decreased by∼101 Gt in 2003−2020,roughly 24 times the Yellow River’s flow into the sea in 2000.Notably,GWS depletion(−7.7 mm/yr)dominates the observed terrestrial water storage(TWS)losses(−6.0 mm/yr)and accounts for>100%of the net TWS decline.Storage losses are largely explained by increases in evapotranspiration(+6.0 mm/yr)driven by revegetation and agricultural irrigation.This is evident in higher evapotranspiration rates(+3 mm/yr)observed in heavily revegetated areas,with irrigation showing an estimated contribution of−6.6 mm/yr on GWS by the PCR-GLOBWB2 model.GWS losses are projected to persist until 2060 by the LSTM model,with a total storage loss of∼237 Gt.With GWS declining and natural recharge growth lagging behind the rise in groundwater demand,the YRB confronts a future of groundwater deficits.The study suggests that although groundwater extraction for agricultural and ecological benefits might appear helpful to the region in the short term,this trajectory is physically unsustainable and detrimental to the water-scarce Yellow River.展开更多
AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 ...AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countriesegions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.展开更多
The safety of low-calorie sweeteners(LCSs)as food additives remains a contentious issue,particularly concerning their influence on precocious puberty for children.The cross-sectional study aims to explore the potentia...The safety of low-calorie sweeteners(LCSs)as food additives remains a contentious issue,particularly concerning their influence on precocious puberty for children.The cross-sectional study aims to explore the potential dose-response relationship between internal exposure to multiple LCS species and onset of pubertal in the school-age population.In total 473 children were recruited from Sanya District,Hainan Province,China,comprising precocious puberty(PP)cases(n=61)with controls(n=48),and early puberty(EP)cases(n=185)with controls(n=179).Results showed that in all groups,five LCSs were detected in over 55%urine samples,with the concentration of xylitol in the EP group(464μ/g vs.387μg/g)was significantly higher than its controls(p<0.05).In the multivariate logistic regression,after creatinine adjustment,cyclamate was associated with a decreased PP risk(odds ratio(OR):0.67,95%CI:0.49,0.93),while xylitol(OR:1.48,95%CI:1.06,2.07)was associated with higher EP risk.Bayesian kernel machine regression model proved that mixed LCS exposure markedly increased EP risk.Mechanistically,LCSs may significantly interfere with DNA oxidative damage and be associated with changes in body mass index(BMI).Mediation analysis further suggested that xylitol exposure may indirectly increase the EP risk by increasing BMI.The epidemiological findings underscore that LCSs may influence pubertal onset,providing a scientific basis for food safety assessments.展开更多
Covalent organic frameworks(COFs)are considered promising catalysts for photocatalytic CO2reduction reaction(pCO2RR)due to facilitated regulations.However,the instability of COFs with dynamic reversible covalent...Covalent organic frameworks(COFs)are considered promising catalysts for photocatalytic CO2reduction reaction(pCO2RR)due to facilitated regulations.However,the instability of COFs with dynamic reversible covalent bonds and the limited modifiability of COFs with irreversible covalent bonds restricted the enhancement of the pCO2RR performance.Herein,three phthalocyanine-based COFs with ether-linked,CoOP,CoPOP,and CoBOP,were successfully prepared via in situ polycondensation using modifiable bis-phthalonitrile.CoBOP achieved a record of syngas performance in pCO2RR systems with photosensitizers and sacrificial agents(CO 83.7 mmol g-1h-1and H_254.7 mmol g-1h-1),surpassing most COF photocatalysts.Additionally,CoOP,CoPOP,and CoBOP exhibit stabilities in extreme environments owing to their irreversible covalent bonds.Experimental and density functional theory analyses confirm that the optimally matched the lowest unoccupied molecular orbital of the linking unit between the photosensitizer and active unit endowed Co BOP with the highest photoelectron transfer efficiency among the three catalysts,boosting its pCO2RR activity.This work is highly instructive for designing COFs with structure-adjustable and irreversible covalent bonds.展开更多
Magnetic skyrmions hold great promise as memory and computing elements in future spintronic devices.Despite the demonstration of various devices,techniques for addressable and high-precision manipulation of individual...Magnetic skyrmions hold great promise as memory and computing elements in future spintronic devices.Despite the demonstration of various devices,techniques for addressable and high-precision manipulation of individual skyrmions remain scarce.This study presents an experimental realization of size-continuous step-resolved skyrmion tuning under ambient conditions using periodic magnetic force microscopy(MFM)excitation.The writing and deletion of selected skyrmions can be achieved in a controlled manner.The skyrmion size can be continuously tuned from hundreds of nanometers down to tens of nanometers,achieving nearly an order of magnitude reduction.The threshold skyrmion size can be significantly reduced.Micromagnetic simulations reveal that the oscillating field can induce partial distortions in skyrmion configurations,thereby mitigating pinning effects and enabling more efficient control.Our results may offer a more efficient and controllable approach for engineering topological spin textures.展开更多
BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.Wh...BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.While a 48-week interferon course is standard,extended therapy may improve HBsAg clearance rates.However,there exists a notable gap in predictive modeling studies concerning extended treatment courses(≥48 weeks).AIM To develop a predictive model for identifying patients who require extended interferon therapy(≥48 weeks)for HBsAg clearance.METHODS This multicenter retrospective study included CHB patients,including those with compensated cirrhosis,who achieved HBsAg clearance(HBsAg<0.05 IU/mL)following treatment with pegylated interferon alpha-2b,either alone or in combination with nucleoside analogs.After propensity score matching,we employed least absolute shrinkage and selection operator(LASSO)regression and multivariate regression to identify independent predictors.RESULTS A total of 688 eligible patients with CHB were enrolled in this study.After propensity score matching at a 1:1 ratio,375 patients remained,including 196 in the training cohort.Among the training cohort,36(18.37%)were classified in the extended course(≥48 weeks)and 160(81.63%)in the regular course(<48 weeks).LASSO and multivariate regression analyses identified baseline HBsAg and cirrhosis as significant risk factors for extended interferon therapy.The model demonstrated strong discriminatory ability,with the area under the curve of 0.83[95%confidence interval(CI):0.76-0.91]for the training cohort and 0.81(95%CI:0.71-0.90)for the externally validated cohort.The model’s predictive efficacy was not influenced by subgroup characteristics.CONCLUSION This study successfully constructed and validated a prediction model based on baseline HBsAg and cirrhosis to identify potential populations that may benefit from extended interferon therapy(≥48 weeks).展开更多
The Akoya pearl oyster Pinctada fucata is a key model for studying bivalve sex determination and reproduction,yet its reproductive molecular mechanisms remain unclear.The Tudor domain-containing proteins(TDRDs)are cri...The Akoya pearl oyster Pinctada fucata is a key model for studying bivalve sex determination and reproduction,yet its reproductive molecular mechanisms remain unclear.The Tudor domain-containing proteins(TDRDs)are critical for animal reproductive development,making their roles in P.fucata worthy of exploration.In this study,we cloned three TDRDs family genes(PfTDRD5,PfTDRD7-like,PfTDRD9-like)from P.fucata,all containing the signature Tudor domain.Additionally,PfTDRD5 has two Limkain,Oskar,and Tudor containing proteins 5 and 7(LOTUS)domains and one La and related RNA-binding proteins(LARPs)superfamily domain.Phylogenetic analysis showed evolutionary conservation with homologous genes from other species.qPCR revealed differential expression:PfTDRD5 and PfTDRD7-like were highly expressed in female tissues(highest in ovary)and peaked in female gonadal resting stage,while PfTDRD9-like was more abundant in male tissues and increased with gamete maturation.In-situ hybridization localized their expression to ovarianesticular follicles and gametes at various stages.All three genes were highly expressed from 4 to 16 cell embryonic stages,suggesting roles in early embryonic development.RNA interference(RNAi)knockdown caused severe gonadal damage,oocyte degeneration,and reduced sperm quantity/motility.This study provided a foundation for exploring TDRDs'roles in bivalve gonadal development,enhancing understanding of reproductive molecular mechanisms in P.fucata and related species.展开更多
The flying foxes optimization(FFO)algorithm,as a newly introduced metaheuristic algorithm,is inspired by the survival tactics of flying foxes in heat wave environments.FFO preferentially selects the best-performing in...The flying foxes optimization(FFO)algorithm,as a newly introduced metaheuristic algorithm,is inspired by the survival tactics of flying foxes in heat wave environments.FFO preferentially selects the best-performing individuals.This tendency will cause the newly generated solution to remain closely tied to the candidate optimal in the search area.To address this issue,the paper introduces an opposition-based learning-based search mechanism for FFO algorithm(IFFO).Firstly,this paper introduces niching techniques to improve the survival list method,which not only focuses on the adaptability of individuals but also considers the population’s crowding degree to enhance the global search capability.Secondly,an initialization strategy of opposition-based learning is used to perturb the initial population and elevate its quality.Finally,to verify the superiority of the improved search mechanism,IFFO,FFO and the cutting-edge metaheuristic algorithms are compared and analyzed using a set of test functions.The results prove that compared with other algorithms,IFFO is characterized by its rapid convergence,precise results and robust stability.展开更多
Childhood bronchial asthma is a common chronic airway inflammatory disease in pediatrics.Long-term use of inhaled steroids alone has practical problems such as insufficient compliance,parents’concerns about adverse h...Childhood bronchial asthma is a common chronic airway inflammatory disease in pediatrics.Long-term use of inhaled steroids alone has practical problems such as insufficient compliance,parents’concerns about adverse hormone reactions,and inadequate seizure control.Non-pharmacological intervention,as a synergistic means of drug therapy,can reduce airway hyperresponsiveness,decrease the frequency of acute attacks,and improve lung function and quality of life in children from multiple perspectives,including environmental control,respiratory rehabilitation,exercise regulation,psychological counseling,nutritional microecology,traditional Chinese medicine external treatment,and digital health management.This article provides a comprehensive review of the mechanisms of action,latest research evidence,and stratified clinical application scenarios of various non-pharmacological interventions.This article looks forward to the development direction of precision,family-oriented,and integrated intervention of traditional Chinese and Western medicine,providing evidence-based reference for the standardized comprehensive management of pediatric asthma.展开更多
Childhood bronchial asthma has clinical characteristics of strong heterogeneity,prolonged course,and easy recurrence of acute attacks.The atypical symptoms of preschool children and low cooperation with traditional te...Childhood bronchial asthma has clinical characteristics of strong heterogeneity,prolonged course,and easy recurrence of acute attacks.The atypical symptoms of preschool children and low cooperation with traditional testing have led to prominent problems such as early missed diagnosis,misdiagnosis,and poor long-term management.Traditional invasive and highly cooperative diagnostic methods are difficult to adapt to the physiological characteristics of children.The new non-invasive diagnostic technology,with its advantages of safety,convenience,and repeatable testing,gradually achieves early screening,inflammation classification,and risk prediction of asthma.At the same time,the traditional extensive management model cannot adapt to the individualized diagnosis and treatment needs of children with different phenotypes.Fine,full-cycle,and intelligent management has become the core direction of childhood asthma prevention and control.This article systematically reviews the clinical application value of new noninvasive diagnostic technologies for childhood asthma,covering cutting-edge technologies such as airway inflammation detection,respiratory acoustic monitoring,and intelligent assisted diagnosis.This article summarizes the research progress on refined long-term management strategies such as hierarchical classification,remote home monitoring,and physical and mental collaboration,providing an evidence-based reference for standardized and individualized comprehensive management of pediatric asthma.展开更多
Optogenetic has been widely applied in various pathogenesis investigations of neuropathic diseases since its accurate and targeted regulation of neuronal activity.However,due to the mismatch between the soft tissues a...Optogenetic has been widely applied in various pathogenesis investigations of neuropathic diseases since its accurate and targeted regulation of neuronal activity.However,due to the mismatch between the soft tissues and the optical waveguide,the long-term neural regulation within soft tissue(such as brain and spinal cord)by implantable optical fibers is a large challenge.Herein,we designed a modulus selfadaptive hydrogel optical fiber(MSHOF)with tunable mechanical properties(Young’modulus was tunable in the range of 0.32-10.56MPa)and low light attenuation(0.12-0.21 dB/cm,472nm laser light),which adapts to light transmission under soft tissues.These advantages of MSHOF can ensure the effectiveness of optogenetic stimulation meanwhile safeguarding the safety of the brain/materials interaction interface.In addition,this work provides more design possibilities of MSHOF for photogenetic stimuli and has significant application prospects in photomedical therapy.展开更多
Electrochemical CO2reduction has been considered a promising approach to neutralizing the global CO2level.As an intriguing technique,metal-CO2battery devices can not only capture CO2into valuable carbonace...Electrochemical CO2reduction has been considered a promising approach to neutralizing the global CO2level.As an intriguing technique,metal-CO2battery devices can not only capture CO2into valuable carbonaceous chem-icals and reduce the CO2concentration in the atmosphere but enable energy conversion.Among metal-CO2batteries,aqueous Zn–CO2batteries,especially rechargeable systems,exhibit flexible CO2electrochemistry in terms of multi-carbon chemicals,which are gaseous or water-soluble,in favor of rechargeability and cycling durability of aqueous battery systems.Despite the increasing number of publications on Zn–CO2batteries in the past three years,this field is still in its beginning stage and facing many challenges considering the capability of CO2fixation and battery performance.Herein,we present a timely and overall summary of the recent progress in Zn–CO2batteries,including fundamental mechanisms,affecting factors on electrochemical performance,catalyst cathodes,and electrolytes(catholytes and anolytes).Besides,we assess the application potential of Zn–CO2batteries and compare this with those of alkali metal-CO2batteries based on CO2fixation and battery perfor-mance.Finally,we point out some current challenges for the further development of Zn–CO2batteries and put forward perspectives of the research directions for practical applications of Zn–CO2batteries in the future.展开更多
Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,inge...Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,ingestion,and dermal contact.The current research on inhalation exposure pays limited attention to the particle distribution of PAEs and BPs in air,although particulate-bound pollutants are usually size-dependent.In this study,we discussed the size resolution of PAEs and BPs in air particles from city waste recycling plants.With paired urine samples of the workers,we also compared the internal and external exposure of PAEs and BPs and related potential health risks.The particulatebound PAEs and BPs concentrated mainly on coarse particles(Dp>2.1μm),with a bimodal distribution,and the peak particle size ranged from 9–10 to 4.7–5.85μm,respectively.Model calculation revealed that the deposition fluxes of PAEs in different respiratory regions followed the sequence of head airways(167±92.8 ng/h)>alveolar region(18.9±9.96 ng/h)>tracheobronchial region(9.20±5.22 ng/h),and the similar trends went for BPs.The daily intakes of PAEs and BPs via dust ingestion were higher than those fromrespiratory inhalation and dermal contact,with mean value of 96 and 0.88 ng/(kg-bw day),respectively.For internal exposure,the estimated daily intakes of PAEs for waste recycling workers were higher than those in e-waste dismantling workers,while the exposure levels of bisphenols were comparable.Overall,the potential health risks from inhalation exposure to particulate-bound PAEs and BPs were low.展开更多
Crop cultivation is intrinsically linked to human well-being,and the timely identification of crop types is critical for agricultural monitoring and food security assessment.However,without extensive field surveys,ach...Crop cultivation is intrinsically linked to human well-being,and the timely identification of crop types is critical for agricultural monitoring and food security assessment.However,without extensive field surveys,achieving timely,large-scale,high-resolution crop identification remains challenging.This study proposes an intelligent crop identification strategy(ICIS)that integrates crop phenological development information with a model transfer strategy based on machine learning,generating 10-meter resolution crop distribution maps of major crop types from 2020 to 2023 in Northeast China(NE).ICIS utilizes time series data from Sentinel-1(S1)and Sentinel-2(S2)to extract multi-source temporal features covering the full growth cycles of maize,rice,and soybeans.A Random Forest(RF)classifier was trained on representative sample sites,and model transfer was employed to predict crop distribution across different years and regions.The experimental results show that the models achieved F1-scores above 0.92 across provinces,peaking at 0.97.For rice,the F1-scores for Jilin,Heilongjiang,and Liaoning remained stable at 0.94.Maize F1-scores consistently exceeded 0.92,and although the soybean accuracy varied spatially,it reached 0.97 in certain areas.Comparison with crop area statistics from the China Statistical Yearbook at the city level revealed that the average root mean square error(RMSE)across four years for the three crops was 8.6×104ha,with coefficients of determination(R2)consistently above 0.90,reaching up to 0.96.These results demonstrated the strong generalizability and robustness of the proposed ICIS Strategy for crop mapping across both temporal and spatial scales.Moreover,this study reveals the complementary strengths and key contributions of optical and Synthetic Aperture Radar(SAR)time series features in modeling crop growth dynamics.Overall,the ICIS provides an efficient and reliable technical means for the rapidly acquiring large-scale crop information.It provides robust support for agricultural monitoring and food security assessment,demonstrates significant potential for large-scale agricultural applications,and offers valuable insights and technical support for remote sensing data processing,image analysis,and machine learning-based agricultural automation and decision-making.展开更多
Isothermal compression tests were used to establish constitutive models of the hot deformation of GH4742 superalloy. The microstructural evolution of double cone samples with large strain gradients during hot deformat...Isothermal compression tests were used to establish constitutive models of the hot deformation of GH4742 superalloy. The microstructural evolution of double cone samples with large strain gradients during hot deformation and subsequent solvus treatment was studied. The results showed that the grain size during dynamic recrystallization (DRX) did not exceed 6 μm, and the volume fraction during DRX did not exceed 45% at all reduction rates when it deformed below the γ′ solvus temperature (1080 ℃). When deformed near the γ′ solvus temperature (1110 ℃), the volume fraction and grain size increase significantly during DRX due to the dissolution and coarsening of some γ′ precipitates. When deformed above the γ′ solvus temperature (1140 ℃), even at a high reduction rate of 20 mm/s, the volume fraction during DRX reached 75%, and the grain size during DRX increased to 25 μm. At a reduction rate of 0.5 mm/s, the grain size during DRX reached 65 μm. When the sample is deformed below the γ′ solvus temperature (1080 ℃), stored strain energy accumulates in the sample, which is beneficial for the development of post dynamic recrystallization during subsequent subsolvus heat treatment, resulting in a noticeable increase in the recrystallization volume fraction. The recrystallization volume fraction of predeformed samples deformed at 1110 and 1140 ℃, followed by subsolvus heat treatment, was almost unchanged. The microstructure of the predeformed sample following supersolvus heat treatment consists of coarse equiaxed grains.展开更多
The Dynamical Density Functional Theory(DDFT)algorithm,derived by associating classical Density Functional Theory(DFT)with the fundamental Smoluchowski dynamical equation,describes the evolution of inhomo-geneous flui...The Dynamical Density Functional Theory(DDFT)algorithm,derived by associating classical Density Functional Theory(DFT)with the fundamental Smoluchowski dynamical equation,describes the evolution of inhomo-geneous fluid density distributions over time.It plays a significant role in studying the evolution of density distributions over time in inhomogeneous systems.The Sunway Bluelight II supercomputer,as a new generation of China’s developed supercomputer,possesses powerful computational capabilities.Porting and optimizing industrial software on this platform holds significant importance.For the optimization of the DDFT algorithm,based on the Sunway Bluelight II supercomputer and the unique hardware architecture of the SW39000 processor,this work proposes three acceleration strategies to enhance computational efficiency and performance,including direct parallel optimization,local-memory constrained optimization for CPEs,and multi-core groups collaboration and communication optimization.This method combines the characteristics of the program’s algorithm with the unique hardware architecture of the Sunway Bluelight II supercomputer,optimizing the storage and transmission structures to achieve a closer integration of software and hardware.For the first time,this paper presents Sunway-Dynamical Density Functional Theory(SW-DDFT).Experimental results show that SW-DDFT achieves a speedup of 6.67 times within a single-core group compared to the original DDFT implementation,with six core groups(a total of 384 CPEs),the maximum speedup can reach 28.64 times,and parallel efficiency can reach 71%,demonstrating excellent acceleration performance.展开更多
Diseases resulting from exaggerated inflammatory responses present a significant peril to human beings,and its pathogenesis and treatment have not been fully elaborated.Traditional Chinese medicine offers the benefit ...Diseases resulting from exaggerated inflammatory responses present a significant peril to human beings,and its pathogenesis and treatment have not been fully elaborated.Traditional Chinese medicine offers the benefit of minimal adverse effects and favorable outcomes in the management of inflammatory diseases.Polygonum cuspidatum,a type of traditional Chinese medicine,refers to the dried rhizomes and roots of the plant species Polygonum cuspidatum from the Polygonaceae family.It has a slightly bitter taste and exhibits a cold nature,exhibiting therapeutic effects such as heat-clearing and detoxification,blood stasis removal and pain relief,phlegm resolution,and cough alleviation.Research has demonstrated that the bioactive constituents found in Polygonum cuspidatum can impede the inflammatory response through the modulation of pertinent pathways.The anti-inflammatory effects of it have been primarily observed in nonalcoholic fatty liver disease,arthritis,ischemic stroke,parkinson’s disease,ulcerative colitis,and diabetes mellitus.This review is conducted by combining papers from the past decade.The anti-inflammatory properties and mechanisms of Polygonum cuspidatum and its natural compounds are summarized.It provides a new theoretical basis for further research on the clinical pharmacological effects of Polygonum cuspidatum.展开更多
Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a seri...Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.42041007)the Project for Innovative Research Group of the Natural Science Foundation of Hebei Province(Grant No.D2025503014)the Innovation Group Project Agricultural Hydrology and Groundwater Sustainability by Hebei Natural Science Foundation(Grant No.D2021503001).
摘要Groundwater storage(GWS)is essential for supporting agricultural irrigation and revegetation in the water scarce Yellow River Basin(YRB).Early studies have mainly focused on the impacts of revegetation on GWS,and rarely consider the influences of agricultural irrigation and other human activities,rendering the driving mechanisms of GWS unclear.Here we used NASA’s Gravity Recovery and Climate Experiment(GRACE)satellite data,the PCR-GLOBWB2 hydrologic model,and an Long Short-Term Memory(LSTM)machine learning approach to reveal changes,driving mechanisms,and future trends in GWS in the YRB.Results show that GWS in the YRB decreased by∼101 Gt in 2003−2020,roughly 24 times the Yellow River’s flow into the sea in 2000.Notably,GWS depletion(−7.7 mm/yr)dominates the observed terrestrial water storage(TWS)losses(−6.0 mm/yr)and accounts for>100%of the net TWS decline.Storage losses are largely explained by increases in evapotranspiration(+6.0 mm/yr)driven by revegetation and agricultural irrigation.This is evident in higher evapotranspiration rates(+3 mm/yr)observed in heavily revegetated areas,with irrigation showing an estimated contribution of−6.6 mm/yr on GWS by the PCR-GLOBWB2 model.GWS losses are projected to persist until 2060 by the LSTM model,with a total storage loss of∼237 Gt.With GWS declining and natural recharge growth lagging behind the rise in groundwater demand,the YRB confronts a future of groundwater deficits.The study suggests that although groundwater extraction for agricultural and ecological benefits might appear helpful to the region in the short term,this trajectory is physically unsustainable and detrimental to the water-scarce Yellow River.
基金Supported by National Natural Science Foundation of China(No.82020108006,No.81730025).
摘要AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countriesegions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation.
基金supported by the National Natural Science Foundation of China(No.22176071)the Natural Science Foundation of Guangdong Province,China(No.2023A1515011879)the Joint Program on Health Science&Technology Innovation of Hainan Province,China(No.SQ2023WSJK0572).
摘要The safety of low-calorie sweeteners(LCSs)as food additives remains a contentious issue,particularly concerning their influence on precocious puberty for children.The cross-sectional study aims to explore the potential dose-response relationship between internal exposure to multiple LCS species and onset of pubertal in the school-age population.In total 473 children were recruited from Sanya District,Hainan Province,China,comprising precocious puberty(PP)cases(n=61)with controls(n=48),and early puberty(EP)cases(n=185)with controls(n=179).Results showed that in all groups,five LCSs were detected in over 55%urine samples,with the concentration of xylitol in the EP group(464μ/g vs.387μg/g)was significantly higher than its controls(p<0.05).In the multivariate logistic regression,after creatinine adjustment,cyclamate was associated with a decreased PP risk(odds ratio(OR):0.67,95%CI:0.49,0.93),while xylitol(OR:1.48,95%CI:1.06,2.07)was associated with higher EP risk.Bayesian kernel machine regression model proved that mixed LCS exposure markedly increased EP risk.Mechanistically,LCSs may significantly interfere with DNA oxidative damage and be associated with changes in body mass index(BMI).Mediation analysis further suggested that xylitol exposure may indirectly increase the EP risk by increasing BMI.The epidemiological findings underscore that LCSs may influence pubertal onset,providing a scientific basis for food safety assessments.
基金financially supported by the Innovation Capability Support Program of Shaanxi—Science and Technology Innovation Team Project(No.2025RS-CXTD-024)the Fundamental Research Foundation of SHCCIG New Materials Technology Research Institute Co.,Ltd(No.D5204230171)+3 种基金the Fundamental Research Funds for the Central Universities(G2025KY05240)the Natural Science Basic Research Program of Shaanxi(Program No.2024JC-YBQN-0073)the Fundamental Research Funds for the Central Universities(No.D5000250204)Young Talent Fund of Association for Science and Technology in Shaanxi(No.20230101)。
摘要Covalent organic frameworks(COFs)are considered promising catalysts for photocatalytic CO2reduction reaction(pCO2RR)due to facilitated regulations.However,the instability of COFs with dynamic reversible covalent bonds and the limited modifiability of COFs with irreversible covalent bonds restricted the enhancement of the pCO2RR performance.Herein,three phthalocyanine-based COFs with ether-linked,CoOP,CoPOP,and CoBOP,were successfully prepared via in situ polycondensation using modifiable bis-phthalonitrile.CoBOP achieved a record of syngas performance in pCO2RR systems with photosensitizers and sacrificial agents(CO 83.7 mmol g-1h-1and H_254.7 mmol g-1h-1),surpassing most COF photocatalysts.Additionally,CoOP,CoPOP,and CoBOP exhibit stabilities in extreme environments owing to their irreversible covalent bonds.Experimental and density functional theory analyses confirm that the optimally matched the lowest unoccupied molecular orbital of the linking unit between the photosensitizer and active unit endowed Co BOP with the highest photoelectron transfer efficiency among the three catalysts,boosting its pCO2RR activity.This work is highly instructive for designing COFs with structure-adjustable and irreversible covalent bonds.
基金financially supported by the National Key R&D Program of China(Grant No.2023YFA1607701)the HFNL Self-Deployed Project(Grant No.ZB2025020100)+2 种基金the National Natural Science Foundation of China(Grant Nos.12527803,51627901,12374225,and 12004386)the Chinese Academy of Sciences Scientific Research Equipment(Grant No.YZ201628)the Maintenance and Renovation Project for CAS Major Scientific and Technological Infrastructure(Grant Nos.DSS-WXGZ-2019-0011 and DSS-WXGZ-2021-0006)。
摘要Magnetic skyrmions hold great promise as memory and computing elements in future spintronic devices.Despite the demonstration of various devices,techniques for addressable and high-precision manipulation of individual skyrmions remain scarce.This study presents an experimental realization of size-continuous step-resolved skyrmion tuning under ambient conditions using periodic magnetic force microscopy(MFM)excitation.The writing and deletion of selected skyrmions can be achieved in a controlled manner.The skyrmion size can be continuously tuned from hundreds of nanometers down to tens of nanometers,achieving nearly an order of magnitude reduction.The threshold skyrmion size can be significantly reduced.Micromagnetic simulations reveal that the oscillating field can induce partial distortions in skyrmion configurations,thereby mitigating pinning effects and enabling more efficient control.Our results may offer a more efficient and controllable approach for engineering topological spin textures.
基金Supported by the Tianjin Health Research Project(Key Project),No.TJWJ2024ZD004.
摘要BACKGROUND Chronic hepatitis B(CHB)is a major global health burden,with China being the most affected.Achieving a clinical cure,defined as hepatitis B surface antigen(HBsAg)clearance,is the ideal treatment endpoint.While a 48-week interferon course is standard,extended therapy may improve HBsAg clearance rates.However,there exists a notable gap in predictive modeling studies concerning extended treatment courses(≥48 weeks).AIM To develop a predictive model for identifying patients who require extended interferon therapy(≥48 weeks)for HBsAg clearance.METHODS This multicenter retrospective study included CHB patients,including those with compensated cirrhosis,who achieved HBsAg clearance(HBsAg<0.05 IU/mL)following treatment with pegylated interferon alpha-2b,either alone or in combination with nucleoside analogs.After propensity score matching,we employed least absolute shrinkage and selection operator(LASSO)regression and multivariate regression to identify independent predictors.RESULTS A total of 688 eligible patients with CHB were enrolled in this study.After propensity score matching at a 1:1 ratio,375 patients remained,including 196 in the training cohort.Among the training cohort,36(18.37%)were classified in the extended course(≥48 weeks)and 160(81.63%)in the regular course(<48 weeks).LASSO and multivariate regression analyses identified baseline HBsAg and cirrhosis as significant risk factors for extended interferon therapy.The model demonstrated strong discriminatory ability,with the area under the curve of 0.83[95%confidence interval(CI):0.76-0.91]for the training cohort and 0.81(95%CI:0.71-0.90)for the externally validated cohort.The model’s predictive efficacy was not influenced by subgroup characteristics.CONCLUSION This study successfully constructed and validated a prediction model based on baseline HBsAg and cirrhosis to identify potential populations that may benefit from extended interferon therapy(≥48 weeks).
基金Supported by the Earmarked Fund for Science and Technology Development supported by the Central Government(No.GK ZY21195020)the Guangxi Natural Science Foundation(No.2021GXNSFAA075008)+1 种基金the Marine Science Program for Guangxi First-Class Discipline,Beibu Gulf University(Nos.DRB001,DRB002)the Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation(Nos.2022ZB02,2022ZA01)。
摘要The Akoya pearl oyster Pinctada fucata is a key model for studying bivalve sex determination and reproduction,yet its reproductive molecular mechanisms remain unclear.The Tudor domain-containing proteins(TDRDs)are critical for animal reproductive development,making their roles in P.fucata worthy of exploration.In this study,we cloned three TDRDs family genes(PfTDRD5,PfTDRD7-like,PfTDRD9-like)from P.fucata,all containing the signature Tudor domain.Additionally,PfTDRD5 has two Limkain,Oskar,and Tudor containing proteins 5 and 7(LOTUS)domains and one La and related RNA-binding proteins(LARPs)superfamily domain.Phylogenetic analysis showed evolutionary conservation with homologous genes from other species.qPCR revealed differential expression:PfTDRD5 and PfTDRD7-like were highly expressed in female tissues(highest in ovary)and peaked in female gonadal resting stage,while PfTDRD9-like was more abundant in male tissues and increased with gamete maturation.In-situ hybridization localized their expression to ovarianesticular follicles and gametes at various stages.All three genes were highly expressed from 4 to 16 cell embryonic stages,suggesting roles in early embryonic development.RNA interference(RNAi)knockdown caused severe gonadal damage,oocyte degeneration,and reduced sperm quantity/motility.This study provided a foundation for exploring TDRDs'roles in bivalve gonadal development,enhancing understanding of reproductive molecular mechanisms in P.fucata and related species.
基金support from the Ningxia Natural Science Foundation Project(2023AAC03361).
摘要The flying foxes optimization(FFO)algorithm,as a newly introduced metaheuristic algorithm,is inspired by the survival tactics of flying foxes in heat wave environments.FFO preferentially selects the best-performing individuals.This tendency will cause the newly generated solution to remain closely tied to the candidate optimal in the search area.To address this issue,the paper introduces an opposition-based learning-based search mechanism for FFO algorithm(IFFO).Firstly,this paper introduces niching techniques to improve the survival list method,which not only focuses on the adaptability of individuals but also considers the population’s crowding degree to enhance the global search capability.Secondly,an initialization strategy of opposition-based learning is used to perturb the initial population and elevate its quality.Finally,to verify the superiority of the improved search mechanism,IFFO,FFO and the cutting-edge metaheuristic algorithms are compared and analyzed using a set of test functions.The results prove that compared with other algorithms,IFFO is characterized by its rapid convergence,precise results and robust stability.
基金Self-funded project of Science and Technology Plan of Baoding,Hebei Province(Project No.:2541ZF273)。
摘要Childhood bronchial asthma is a common chronic airway inflammatory disease in pediatrics.Long-term use of inhaled steroids alone has practical problems such as insufficient compliance,parents’concerns about adverse hormone reactions,and inadequate seizure control.Non-pharmacological intervention,as a synergistic means of drug therapy,can reduce airway hyperresponsiveness,decrease the frequency of acute attacks,and improve lung function and quality of life in children from multiple perspectives,including environmental control,respiratory rehabilitation,exercise regulation,psychological counseling,nutritional microecology,traditional Chinese medicine external treatment,and digital health management.This article provides a comprehensive review of the mechanisms of action,latest research evidence,and stratified clinical application scenarios of various non-pharmacological interventions.This article looks forward to the development direction of precision,family-oriented,and integrated intervention of traditional Chinese and Western medicine,providing evidence-based reference for the standardized comprehensive management of pediatric asthma.
基金Self-funded project of Science and Technology Plan of Baoding,Hebei Province(Project No.:2541ZF273)。
摘要Childhood bronchial asthma has clinical characteristics of strong heterogeneity,prolonged course,and easy recurrence of acute attacks.The atypical symptoms of preschool children and low cooperation with traditional testing have led to prominent problems such as early missed diagnosis,misdiagnosis,and poor long-term management.Traditional invasive and highly cooperative diagnostic methods are difficult to adapt to the physiological characteristics of children.The new non-invasive diagnostic technology,with its advantages of safety,convenience,and repeatable testing,gradually achieves early screening,inflammation classification,and risk prediction of asthma.At the same time,the traditional extensive management model cannot adapt to the individualized diagnosis and treatment needs of children with different phenotypes.Fine,full-cycle,and intelligent management has become the core direction of childhood asthma prevention and control.This article systematically reviews the clinical application value of new noninvasive diagnostic technologies for childhood asthma,covering cutting-edge technologies such as airway inflammation detection,respiratory acoustic monitoring,and intelligent assisted diagnosis.This article summarizes the research progress on refined long-term management strategies such as hierarchical classification,remote home monitoring,and physical and mental collaboration,providing an evidence-based reference for standardized and individualized comprehensive management of pediatric asthma.
基金supported by the National Key Research and Development Program of China(Nos.2021YFA1201302 and 2021YFA1201300)the National Natural Science Foundation of China(Nos.52303033,52173029)+1 种基金Shanghai Sailing Program(No.23YF1400400)the Natural Science Foundation of Shanghai(No.21ZR1400500).
摘要Optogenetic has been widely applied in various pathogenesis investigations of neuropathic diseases since its accurate and targeted regulation of neuronal activity.However,due to the mismatch between the soft tissues and the optical waveguide,the long-term neural regulation within soft tissue(such as brain and spinal cord)by implantable optical fibers is a large challenge.Herein,we designed a modulus selfadaptive hydrogel optical fiber(MSHOF)with tunable mechanical properties(Young’modulus was tunable in the range of 0.32-10.56MPa)and low light attenuation(0.12-0.21 dB/cm,472nm laser light),which adapts to light transmission under soft tissues.These advantages of MSHOF can ensure the effectiveness of optogenetic stimulation meanwhile safeguarding the safety of the brain/materials interaction interface.In addition,this work provides more design possibilities of MSHOF for photogenetic stimuli and has significant application prospects in photomedical therapy.
基金supported by the National Key R&D Program of China under Project 2019YFA0705104GRF under Project CityU11212920.
摘要Electrochemical CO2reduction has been considered a promising approach to neutralizing the global CO2level.As an intriguing technique,metal-CO2battery devices can not only capture CO2into valuable carbonaceous chem-icals and reduce the CO2concentration in the atmosphere but enable energy conversion.Among metal-CO2batteries,aqueous Zn–CO2batteries,especially rechargeable systems,exhibit flexible CO2electrochemistry in terms of multi-carbon chemicals,which are gaseous or water-soluble,in favor of rechargeability and cycling durability of aqueous battery systems.Despite the increasing number of publications on Zn–CO2batteries in the past three years,this field is still in its beginning stage and facing many challenges considering the capability of CO2fixation and battery performance.Herein,we present a timely and overall summary of the recent progress in Zn–CO2batteries,including fundamental mechanisms,affecting factors on electrochemical performance,catalyst cathodes,and electrolytes(catholytes and anolytes).Besides,we assess the application potential of Zn–CO2batteries and compare this with those of alkali metal-CO2batteries based on CO2fixation and battery perfor-mance.Finally,we point out some current challenges for the further development of Zn–CO2batteries and put forward perspectives of the research directions for practical applications of Zn–CO2batteries in the future.
基金supported by the National Natural Science Foundation of China(No.22176071)the Natural Science Foundation of Guangdong Province,China(No.2023A1515011879).
摘要Phthalate(PAEs)and Bisphenols(BPs)are plasticizers or additives in consumer products.They are typical endocrine disruptors,and potential health hazards may occur when people are exposed to them through inhalation,ingestion,and dermal contact.The current research on inhalation exposure pays limited attention to the particle distribution of PAEs and BPs in air,although particulate-bound pollutants are usually size-dependent.In this study,we discussed the size resolution of PAEs and BPs in air particles from city waste recycling plants.With paired urine samples of the workers,we also compared the internal and external exposure of PAEs and BPs and related potential health risks.The particulatebound PAEs and BPs concentrated mainly on coarse particles(Dp>2.1μm),with a bimodal distribution,and the peak particle size ranged from 9–10 to 4.7–5.85μm,respectively.Model calculation revealed that the deposition fluxes of PAEs in different respiratory regions followed the sequence of head airways(167±92.8 ng/h)>alveolar region(18.9±9.96 ng/h)>tracheobronchial region(9.20±5.22 ng/h),and the similar trends went for BPs.The daily intakes of PAEs and BPs via dust ingestion were higher than those fromrespiratory inhalation and dermal contact,with mean value of 96 and 0.88 ng/(kg-bw day),respectively.For internal exposure,the estimated daily intakes of PAEs for waste recycling workers were higher than those in e-waste dismantling workers,while the exposure levels of bisphenols were comparable.Overall,the potential health risks from inhalation exposure to particulate-bound PAEs and BPs were low.
基金supported by the National Natural Science Foundation of China(U21A2040)the National K&D Program of China(2022YFD2300201)the National K&D Program of China(2023YFD2301701).
摘要Crop cultivation is intrinsically linked to human well-being,and the timely identification of crop types is critical for agricultural monitoring and food security assessment.However,without extensive field surveys,achieving timely,large-scale,high-resolution crop identification remains challenging.This study proposes an intelligent crop identification strategy(ICIS)that integrates crop phenological development information with a model transfer strategy based on machine learning,generating 10-meter resolution crop distribution maps of major crop types from 2020 to 2023 in Northeast China(NE).ICIS utilizes time series data from Sentinel-1(S1)and Sentinel-2(S2)to extract multi-source temporal features covering the full growth cycles of maize,rice,and soybeans.A Random Forest(RF)classifier was trained on representative sample sites,and model transfer was employed to predict crop distribution across different years and regions.The experimental results show that the models achieved F1-scores above 0.92 across provinces,peaking at 0.97.For rice,the F1-scores for Jilin,Heilongjiang,and Liaoning remained stable at 0.94.Maize F1-scores consistently exceeded 0.92,and although the soybean accuracy varied spatially,it reached 0.97 in certain areas.Comparison with crop area statistics from the China Statistical Yearbook at the city level revealed that the average root mean square error(RMSE)across four years for the three crops was 8.6×104ha,with coefficients of determination(R2)consistently above 0.90,reaching up to 0.96.These results demonstrated the strong generalizability and robustness of the proposed ICIS Strategy for crop mapping across both temporal and spatial scales.Moreover,this study reveals the complementary strengths and key contributions of optical and Synthetic Aperture Radar(SAR)time series features in modeling crop growth dynamics.Overall,the ICIS provides an efficient and reliable technical means for the rapidly acquiring large-scale crop information.It provides robust support for agricultural monitoring and food security assessment,demonstrates significant potential for large-scale agricultural applications,and offers valuable insights and technical support for remote sensing data processing,image analysis,and machine learning-based agricultural automation and decision-making.
基金supported by the National Science and Technology Major Project of China(2017-VI-0018-0090).
摘要Isothermal compression tests were used to establish constitutive models of the hot deformation of GH4742 superalloy. The microstructural evolution of double cone samples with large strain gradients during hot deformation and subsequent solvus treatment was studied. The results showed that the grain size during dynamic recrystallization (DRX) did not exceed 6 μm, and the volume fraction during DRX did not exceed 45% at all reduction rates when it deformed below the γ′ solvus temperature (1080 ℃). When deformed near the γ′ solvus temperature (1110 ℃), the volume fraction and grain size increase significantly during DRX due to the dissolution and coarsening of some γ′ precipitates. When deformed above the γ′ solvus temperature (1140 ℃), even at a high reduction rate of 20 mm/s, the volume fraction during DRX reached 75%, and the grain size during DRX increased to 25 μm. At a reduction rate of 0.5 mm/s, the grain size during DRX reached 65 μm. When the sample is deformed below the γ′ solvus temperature (1080 ℃), stored strain energy accumulates in the sample, which is beneficial for the development of post dynamic recrystallization during subsequent subsolvus heat treatment, resulting in a noticeable increase in the recrystallization volume fraction. The recrystallization volume fraction of predeformed samples deformed at 1110 and 1140 ℃, followed by subsolvus heat treatment, was almost unchanged. The microstructure of the predeformed sample following supersolvus heat treatment consists of coarse equiaxed grains.
基金supported by National Key Research and Development Program of China under Grant 2024YFE0210800National Natural Science Foundation of China under Grant 62495062Beijing Natural Science Foundation under Grant L242017.
摘要The Dynamical Density Functional Theory(DDFT)algorithm,derived by associating classical Density Functional Theory(DFT)with the fundamental Smoluchowski dynamical equation,describes the evolution of inhomo-geneous fluid density distributions over time.It plays a significant role in studying the evolution of density distributions over time in inhomogeneous systems.The Sunway Bluelight II supercomputer,as a new generation of China’s developed supercomputer,possesses powerful computational capabilities.Porting and optimizing industrial software on this platform holds significant importance.For the optimization of the DDFT algorithm,based on the Sunway Bluelight II supercomputer and the unique hardware architecture of the SW39000 processor,this work proposes three acceleration strategies to enhance computational efficiency and performance,including direct parallel optimization,local-memory constrained optimization for CPEs,and multi-core groups collaboration and communication optimization.This method combines the characteristics of the program’s algorithm with the unique hardware architecture of the Sunway Bluelight II supercomputer,optimizing the storage and transmission structures to achieve a closer integration of software and hardware.For the first time,this paper presents Sunway-Dynamical Density Functional Theory(SW-DDFT).Experimental results show that SW-DDFT achieves a speedup of 6.67 times within a single-core group compared to the original DDFT implementation,with six core groups(a total of 384 CPEs),the maximum speedup can reach 28.64 times,and parallel efficiency can reach 71%,demonstrating excellent acceleration performance.
基金supported by grants from Zhejiang Chinese Medicine University affiliated hospital research project(2023FSYYZZ18)scientific research item(2022FH001),School of Life Sciences,Zhejiang Chinese Medicine University.
摘要Diseases resulting from exaggerated inflammatory responses present a significant peril to human beings,and its pathogenesis and treatment have not been fully elaborated.Traditional Chinese medicine offers the benefit of minimal adverse effects and favorable outcomes in the management of inflammatory diseases.Polygonum cuspidatum,a type of traditional Chinese medicine,refers to the dried rhizomes and roots of the plant species Polygonum cuspidatum from the Polygonaceae family.It has a slightly bitter taste and exhibits a cold nature,exhibiting therapeutic effects such as heat-clearing and detoxification,blood stasis removal and pain relief,phlegm resolution,and cough alleviation.Research has demonstrated that the bioactive constituents found in Polygonum cuspidatum can impede the inflammatory response through the modulation of pertinent pathways.The anti-inflammatory effects of it have been primarily observed in nonalcoholic fatty liver disease,arthritis,ischemic stroke,parkinson’s disease,ulcerative colitis,and diabetes mellitus.This review is conducted by combining papers from the past decade.The anti-inflammatory properties and mechanisms of Polygonum cuspidatum and its natural compounds are summarized.It provides a new theoretical basis for further research on the clinical pharmacological effects of Polygonum cuspidatum.
摘要Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.