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Quantifying the contribution of triple compound extreme events to global yield loss of major staple crops from 1982 to 2016 认领 引用 被引量：1
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作者 Kun Xiao Ying Sun +6 位作者 Wei Wu Xuewen Zhou Zhicheng Zhang Qiuyao Lai Chen Huang Zhenhua Xiong Qinchuan Xin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第10期4078-4099,共22页
The increasing frequency of compound extreme events under ongoing climate change threatens global food security.Compared to individual extreme events,the simultaneous occurrence of multiple extreme events can exacerba... The increasing frequency of compound extreme events under ongoing climate change threatens global food security.Compared to individual extreme events,the simultaneous occurrence of multiple extreme events can exacerbate crop yield reductions,yet comprehensive assessments of these compound effects remain limited.To bridge this gap,we applied a linear mixed-effects model to quantify the impacts of individual extreme events(cold days(CD)and killing degree days(KDD))and triple compound extreme events(heatwave and low precipitation(HWLP)and hot-dry-windy(HDW))on the global yields of winter wheat,soybeans,and maize from 1982 to 2016.Our analysis indicated that regions severely impacted by extreme events(exceeding the 95%threshold)experienced total crop yield losses of more than 9.16,24.89,26.69,and 7.12%due to CD,KDD,HWLP,and HDW,respectively.The adverse effects of compound events were particularly pronounced during critical growth stages.HWLP results in yield losses of 9.4%for winter wheat and 6.8%for maize per 10 hours of exposure during the heading to harvesting stages,while soybean yields declined by 8.8%per 10 hours during the planting to three-true-leaf stage.Similarly,KDD caused a 7.4%yield reduction in winter wheat per 10°C day during the heading to harvesting stages,a 9.5%reduction in maize per 10°C day during the planting to jointing stages,and a 3.8%reduction in soybean per 10°C day during the planting to three-true-leaf stages.These findings underscore the substantial contribution of compound extreme events,which are often overlooked in existing risk assessments,in determining the global yields of major staple crops. 展开更多
关键词 food security crop yield loss compound extreme events climate change
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UV-B and mechanical wounding synergistically induce α-farnesene biosynthesis via CsHY5-CsMYC2 cooperation during oolong tea processing 认领 引用 被引量：1
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作者 Jingjie Cao Dandan Li +5 位作者 Xiaohui Wang Xin He Ying Sun Xin Cheng Xiaochun Wan Linlin Liu 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第1期161-171,共11页
UV-B application enhances the aroma quality of oolong tea;however,the underlying regulatory mechanism remains unclear.This study investigates the regulatory role of UV-B in the biosynthesis of a-farnesene,an important... UV-B application enhances the aroma quality of oolong tea;however,the underlying regulatory mechanism remains unclear.This study investigates the regulatory role of UV-B in the biosynthesis of a-farnesene,an important floral and fruity characteristic aroma.UV-B treatment significantly improved the aroma quality of‘Foshou’and‘Yuquan’oolong teas,increasing a-farnesene levels by 1.8-and 1.4-fold,respectively.The a-farnesene synthase(CsAFS),ELONGATED HYPOCOTYL 5(CsHY5),and myelocytomatosis protein 2(CsMYC2)exhibited a highly correlated expression pattern closely associated with a-farnesene accumulation.Single-factor treatment revealed that CsAFS expression was induced by both UV-B and mechanical wounding,with CsHY5 predominantly responding to UV-B radiation,while CsMYC2 primarily responded to tumbling-induced mechanical wounding signal.Transient suppression of CsHY5 in tea leaves reduced the expression of both CsAFS and CsMYC2 whereas CsMYC2 suppression decreased CsAFS expression.G-box motifs were identified in promoters of CsMYC2 and CsAFS,and the dual-luciferase reporter assay(LUC)and electrophoretic mobility shift assays(EMSA)demonstrated direct binding functions of CsHY5 to CsAFS and CsMYC2 promoters,as well as CsMYC2 to the CsAFS promoter.Based on sensory evaluation,odourant quantification,gene expression,and molecular functional analysis,we propose that UV-B radiation and tumbling-induced wounding signals synergistically regulate a-farnesene biosynthesis through a coordinated interaction of CsHY5 and CsMYC2 during oolong tea processing.These findings improve our understanding of flavour formation during oolong tea production and also provide novel insights into artificial light application in tea manufacturing. 展开更多
关键词 Camellia sinensis Aroma formation a-farnesene synthase Light Abiotic stress
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Detecting farmland green production efficiency considering Sustainable Development Goals(SDGs)in the Yellow River Basin:Dynamics,drivers,and challenges 认领 引用
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作者 Chaoqing Chai Yuanyuan Li +10 位作者 Ronghao Wen Hui Zhang Bangbang Zhang Peixue Xingc Ying Sun Huadong Zhu Guanghui Hou Haoyang Wang Wenhao Niu Weiwei Zheng Xiangbin Kong 《Geography and Sustainability》 CSCD 2026年第2期87-101,共15页
Pursuing sustainable growth of Farmland Green Production Efficiency(FGPE)is crucial for achieving multiple Sustainable Development Goals(SDGs),particularly SDG2(Zero Hunger),SDG 12(Responsible Consumption and Producti... Pursuing sustainable growth of Farmland Green Production Efficiency(FGPE)is crucial for achieving multiple Sustainable Development Goals(SDGs),particularly SDG2(Zero Hunger),SDG 12(Responsible Consumption and Production),SDG13(Climate Action),and SDG 15(Life on Land)in ecologically fragile basins.However,the dynamics,drivers,and challenges of FGPE remain underexplored within the SDGs framework,especially at finer spatial scale and across coupled“society-economy-policy-climate”(SEPC)drivers.This study develops an FGPE assessment framework through SDGs lens,utilizing“elements-processes-functions-drivers”paradigm and data from 447 counties in the Yellow River Basin(YRB)from 2000 to 2022.We apply super-efficiency Slacks-Based Measure and Malmquist-Luenberger(SBM-ML),spatial correlation analysis,and geographically and temporally weighted regression models to assess FGPE growth challenges.Results reveal a“U-shaped”trend in the number of high-FGPE counties,with a rapid increase after 2016.Specifically,FGPE across the YRB increased by 97.6%from 2000 to 2022,though spatial correlation declined by 44.7%,indicating weakening spatial spillover effect.Despite the overall progress,the YRB still faces multiple challenges,including uneven regional development,weakening spatial correlation,climate sensitivity,economic structural shift,and weak policy effect.The findings highlight that FGPE improvement align with key SDGs targets,including enhancing food security(SDG 2),promoting sustainable production(SDG 12),increasing climate resilience(SDG 13),and conserving land ecosystems(SDG 15).Region-specific strategies are recommended:enhancing climate resilience and ecological conservation in the upper reaches,promoting technological diffusion via urban-industrial transformation in the middle reaches,and advancing green agricultural technologies with more local financial support in the lower reaches. 展开更多
关键词 Farmland Green Production Efficiency(FGPE) Sustainable Development Goals(SDGs) Spatial-temporal evolution dynamics Society-economy-policy-climate(SEPC) coupled drivers Key challenges Yellow River Basin(YRB)
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The medium-energy electron detector on board CSES-02 认领 引用
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作者 GuoHong Shen ZhenXia Zhang +7 位作者 DongHui Hou HuanXin Zhang Ying Sun ChunQin Wang Bin Yuan Ping Zhou ZiDa Quan YaoDe Sheng 《Earth and Planetary Physics》 EI CSCD 2026年第4期668-677,共10页
The medium-energy electron detector on board China's second earthquake-monitoring satellite can measure the energy,flux,and direction of medium-and high-energy electrons within the satellite's orbit.These data... The medium-energy electron detector on board China's second earthquake-monitoring satellite can measure the energy,flux,and direction of medium-and high-energy electrons within the satellite's orbit.These data may provide the technical means for exploring new technologies and methods for earthquake monitoring and prediction.This work presents a description of the scientific objectives,key technical specifications,payload design,and results of ground calibration and verification for the payload. 展开更多
关键词 China’s second Seismo-Electromagnetic Satellite(CSES-02) medium-energy electron detector energy spectrum particle direction pitch angle distribution earthquake monitoring
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Damage behavior of aircraft radome under high-speed jet impact 认领 引用
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作者 Minggong SHA Yutong LI +5 位作者 Ming LI Zheng WEI Ying SUN Arseny BABAYTSEV Gregory FEDOTENKOV Yulong LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第2期215-233,共19页
As the main component of the aircraft leading edge,the radome is often the first to be hit by raindrops and cause structural damage when passing through a rain field.Rain resistant coating is usually applied to ensure... As the main component of the aircraft leading edge,the radome is often the first to be hit by raindrops and cause structural damage when passing through a rain field.Rain resistant coating is usually applied to ensure the performance protection requirements.In order to clarify the rain erosion damage mechanism of radome coating and explore the influencing factors and mechanisms of coating material damage under different jet impact conditions,impact tests were conducted on three types of skin coating samples,and the damage mode was observed through electron microscopy characterization.The experimental results show that the typical morphology of rain erosion damage is annular surface peeling damage.The damage area and volume of the three coating samples increase with the continuous increase of raindrop impact velocity.The threshold velocity for initial damage to the coating is about 360 m/s;under the influence of the velocity component,the reduction in impact angle leads to a gradual reduction in the degree of damage to the sample.ABAQUS finite element simulation software was used to establish a constitutive model for coating rain erosion simulation and obtain the propagation law of stress waves during the impact process.The simulation results show that at the 75°impact angle,the jet impacts the surface of the specimen at different velocities,and as the impact velocity increases,the Mises equivalent stress on the surface shows an increasing trend,which is one of the main factors causing damage with increasing velocity.The effectiveness,rain erosion damage mode,and influencing mechanism of the model were verified based on the test results;the dynamic failure mechanism of the sample was further studied,and the stress propagation process at different impact angles was compared,revealing the influence mechanism and damage law of the impact angle on the high-speed raindrop impact of the material. 展开更多
关键词 Coating High-speed jet Impact dynamics Radome Rain erosion damage
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Zonotope-Based Distributed Fusion for 2-D Binary Sensor Systems Under FlexRay Protocols 认领 引用
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作者 Lan Lan Guoliang Wei Ying Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第7期1600-1609,共10页
In this paper,a zonotopic distributed fusion estimation problem is investigated for a class of 2-D nonlinear systems subject to unknown-but-bounded noises over a binary sensor network.An auxiliary innovation is constr... In this paper,a zonotopic distributed fusion estimation problem is investigated for a class of 2-D nonlinear systems subject to unknown-but-bounded noises over a binary sensor network.An auxiliary innovation is constructed to reduce the influence of the less measured information,and Flex Ray protocol is employed to schedule the innovation transmission between nodes.By resorting to the set-membership filtering,a variable-independent zonotope is achieved to constrain local estimation error,and gain parameters are obtained by minimizing the upper bound of zonotope in the F-radius sense.Subsequently,a zonotopic distributed fusion scheme is implemented through the matrixweighted fusion criteria,and an optimized weighted matrix is obtained using the Lagrange Multiple method.Furthermore,the monotonicity of the local zonotope is analyzed with the gain-constraint parameter.Finally,a numerical example is considered to verify the effectiveness of the developed fusion algorithm. 展开更多
关键词 Binary sensor distributed fusion 2-D nonlinear systems FlexRay protocols zonotope
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Prostaglandins:Key players in immunomodulation of the nervous system 认领 引用
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作者 Ziqin Wang Ying Sun +6 位作者 Minjie Luo Nina He Zhongchi Wen Zuzhen Wang Yonglong Zhang Jie Zhao Ying Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4076-4088,共13页
As a class of bioactive substances that play important roles in a variety of physiological and pathological processes,prostaglandins have attracted increasing research attention.Published studies have identified the m... As a class of bioactive substances that play important roles in a variety of physiological and pathological processes,prostaglandins have attracted increasing research attention.Published studies have identified the molecular characteristics of prostaglandins in peripheral organs,the enzymes involved in prostaglandin biosynthesis,and prostaglandin receptors.Some studies have also explored the characteristics of prostaglandins and their functions in the central nervous system.In particular,for immunomodulation,prostaglandins in the brain show a unique immunosuppressive effect,which is of great importance for maintaining brain immune homeostasis and preventing excessive immune responses.In this review,we review the biosynthesis and degradation of prostaglandins,discuss the regulatory effects of prostaglandin systems on the immune cells of the nervous system,and explore the therapeutic potential of targeting prostaglandin systems for neurological diseases,thereby providing new perspectives for the treatment of these diseases.Overall,prostaglandins play important roles in the immunomodulation of the nervous system,and the complexity of the underlying processes depends on the variety and types of specific receptors and,more importantly,the cell types prostaglandins act on.Therefore,additional in-depth studies of the specific mechanisms involving prostaglandins in immunomodulation,including the interactions among different types of prostaglandins and their roles in neuropathological conditions,are essential.The prostaglandin signaling pathway may represent another important direction for the development of new drugs for neurological diseases,and the combination of prostaglandin system targets with other therapies(such as immunomodulatory drugs and gene therapy)may yield better results. 展开更多
关键词 autoimmune neurological diseases cerebrovascular destructive disease immune cells of the nervous system immunomodulatory nervous system neuralgia and chronic pain neurodegenerative diseases neuroinflammation prostaglandin prostaglandin receptor
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Scalable fabrication of high-performance asymmetric hierarchical porous membranes for alkaline water electrolysis 认领 引用
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作者 Jingyu Pan Dezhou Gao +6 位作者 Qing Shang Heyi Li Yujia Xie Ming Jiang Ying Sun Guang Yang Xupin Zhuang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第2期589-597,I0014,共9页
Alkaline water electrolysis(AWE)represents a promising approach for green hydrogen production,yet the development of high-performance separators with gas impermeability,high ion conductivity,and stability under alkali... Alkaline water electrolysis(AWE)represents a promising approach for green hydrogen production,yet the development of high-performance separators with gas impermeability,high ion conductivity,and stability under alkaline operating conditions has proven challenging.To address this challenge,we develop a pre-concentration regulated phase separation strategy for scalable fabrication of asymmetric hierarchical porous membranes(AHPMs)for AWE.The resulting AHPMs demonstrate a hierarchical structure composed of an ultrathin dense skin layer and highly interconnected porous support.Benefitting from the structural advantages,the AHPMs exhibit outstanding characteristics,including a high bubble point pressure up to 12.4 bar,extremely low area resistance of 0.03Ωcm2 in 30 wt%KOH at 80℃,and excellent hydrophilicity and long-term alkaline stability.When applied in AWE with commercial catalysts,the AHPMs achieved an impressive current density of 1.9 A cm-2 at 2.0 V in 30 wt%KOH and the anodic hydrogen contents(AHCs)below 0.5 vol.%at a low current density of 0.1 A cm-2,differential pressure of 2 bar,and temperature of 80℃.Moreover,AHPMs demonstrate exceptional stability over 2,400 h of continuous operation and maintain superior performance in a 1 Nm3 h-1 industrialscale electrolyzer stack.This work advances the development of efficient separators for highperformance AWE systems,contributing to the advancement of hydrogen technologies in sustainable energy applications. 展开更多
关键词 Alkaline water electrolysis Hydrogen Separators Asymmetric membranes Phase separation
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Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care 认领 引用
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作者 Longhui Hao Yi Zhang +8 位作者 Ying Sun Yanqi Han Jun Ye Hongliang Wang Lili Gao Dong Wang Yue Gao Yanfang Yang Yuling Liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期147-160,共14页
Compared to synthetic chemical compounds,plant extracts derived from natural sources have emerged as the"new favorites"in the treatment and care of skin diseases due to their distinct advantages,including be... Compared to synthetic chemical compounds,plant extracts derived from natural sources have emerged as the"new favorites"in the treatment and care of skin diseases due to their distinct advantages,including being environmentally friendly,sustainable,and safe.However,challenges such as poor solubility,limited permeability,and the barrier function of the stratum corneum significantly restrict the application of natural products in dermal drug delivery.Fortunately,advancements in nanotechnology offer promising solutions to overcome these challenges.Different skin diseases and treatments require the precise delivery of natural active ingredients to specific skin layers,and the unique structure of nanocarriers enables targeted delivery to achieve desired therapeutic outcomes.This paper begins by exploring the pathogenesis and therapeutic targets of common skin conditions,including atopic dermatitis(AD),psoriasis,decubitus ulcers,diabetic foot ulcers(DFUs),as well as applications in antioxidant therapies and anti-aging strategies.Furthermore,it provides a detailed overview of the depths and locations within the skin where active compounds must be delivered to exert their effects effectively.Subsequently,this review categorizes and examines natural products based on their therapeutic effects on various skin diseases.It then highlights the skin depths and specific sites that can be targeted by different delivery systems designed to enhance skin permeability,tailored to meet the needs of skin disease treatment or care.By addressing these aspects,this review aims to provide a valuable reference for advancing research on nano-delivery systems in the field of topical skin drug delivery for the treatment and management of skin diseases. 展开更多
关键词 Nano-delivery systems Natural products Topical skin drug delivery Skin diseases Skin care and beauty
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Ablation of hepatocellular carcinoma at high-risk sites based on nanosecond pulsed electric field 认领 引用
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作者 Gang Dong Shan-Shuo Liu +5 位作者 Zhen-Guo Liu Ying Sun Ya-Wen Zou Zu-Jiang Yu Xin-Hua Chen Zhi-Gang Ren 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2026年第4期457-462,共6页
To the Editor:Local ablation is crucial in the treatment of hepatocellular car-cinoma(HCC)and is widely regarded as a good alternative to surgical intervention for achieving local control of HCC.However,the most commo... To the Editor:Local ablation is crucial in the treatment of hepatocellular car-cinoma(HCC)and is widely regarded as a good alternative to surgical intervention for achieving local control of HCC.However,the most commonly used methods for treating HCC are radiofre-quency ablation(RFA)and microwave ablation(MWA),which are thermal ablation methods with limited applicability for tumors in special locations.For example,thermal damage to adjacent impor-tant structures(such as blood vessels,bile ducts and intestines)leads to serious complications.Moreover,thermal ablation of tu-mors near large blood vessels is associated with a higher incidence of incomplete eradication(i.e.,the heat-sink effect)[1,2]. 展开更多
关键词 local control microwave ablation mwa which blood vesselsbile ducts Hepatocellular carcinoma Local ablation Radiofrequency ablation thermal ablation methods surgical intervention
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Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes 认领 引用
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作者 Ying Sun Kai Yan +8 位作者 Yi Zhang Yan-Qi Han Long-Hui Hao Yue Gao Hong-Liang Wang Hong-Qian Chu Jun Ye Yu-Ling Liu Yan-Fang Yang 《Military Medical Research》 SCIE CAS CSCD 2026年第7期1123-1170,共48页
Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influenci... Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influencing the progression of various non-metabolic diseases such as kidney diseases,cancer,neurodegenerative disorders,aging,and bone-related diseases.The metabolic pathways involved in lipid metabolism are complex and highly interconnected.Although the abundance of metabolic targets presents opportunities for lipid metabolism regulation,the limited precision and safety of traditional therapeutic approaches remain significant challenges.These limitations have catalyzed the development of multifunctional nano-delivery platforms aimed at targeted intervention in lipid metabolic processes,further enhancing the flexibility of lipid metabolism regulation.This review outlines the latest advancements and representative applications of these multifunctional nano-delivery platforms.Notably,extensive research has been conducted on nanoparticles and liposomes,with these technologies being relatively mature.Furthermore,numerous novel biomaterials,including engineered adipocytes,exosome vesicles secreted by natural cells,smart-responsive nanomicelles,composite hydrogels,and engineered lipid droplets,are being increasingly explored.Finally,the review discusses the advantages of drug delivery strategies based on the targeted intervention of lipid metabolic processes,the limitations of current technologies,promising future research directions,and treatment challenges. 展开更多
关键词 Multifunctional nano-delivery system Lipid metabolism Lipid metabolism reprogramming Lipid metabolism-related diseases
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Risk factors and fatigue in difficult-to-treat Crohn’s disease:A crosssectional study of a Chinese cohort 认领 引用
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作者 Zhi Wu Zhi-Wei Huang +6 位作者 Zhi-Jun Cao Ying Sun Xin-Xian Zhao Wen-Fang Xu Sheng-Liang Chen Yue Zhang Shu-Liang Zhao 《World Journal of Gastroenterology》 SCIE CAS 2026年第26期75-86,共12页
BACKGROUND Fatigue is a prevalent and debilitating symptom in Crohn’s disease(CD).Recently,an international consensus proposed operative definitions for difficult-totreat(DTT)inflammatory bowel disease.However,the ri... BACKGROUND Fatigue is a prevalent and debilitating symptom in Crohn’s disease(CD).Recently,an international consensus proposed operative definitions for difficult-totreat(DTT)inflammatory bowel disease.However,the risk factors for DTT-CD in the Chinese population and the relationship between fatigue and DTT-CD criteria remain unexplored.AIM To investigate the risk factors for DTT-CD in a Chinese cohort and investigate its association with fatigue.METHODS This single-center retrospective cohort study enrolled 175 CD patients from 2018 to 2024.DTT-CD was defined according to the consensus criteria of the International Organization for the Study of Inflammatory Bowel Diseases.Clinical characteristics,laboratory data,and fatigue assessed by the Multidimensional Fatigue Inventory were analyzed.Logistic and linear regression models were used to identify risk factors for DTT-CD and factors associated with fatigue.RESULTS Overall,51.4%of patients met at least one DTT-CD criterion,with complex perianal disease being the most common(75.6%).Independent risk factors for DTT-CD included longer disease duration[odds ratio(OR)=1.095,P=0.014];elevated interleukin(IL)-5(OR=2.715,P=0.002)and IL-10(OR=1.234,P=0.045);higher hemoglobin(OR=1.025,P=0.016);and need for partial enteral nutrition(PEN)(OR=2.940,P=0.017).DTT-CD patients had significantly higher mental fatigue scores than non-DTT-CD patients(P=0.036).Among DTT-CD patients,fatigue was independently associated with partial enteral nutrition,diagnosis at age>40 years,and surgical history.Factors related to the diagnosis of DTT-CD,such as complex perianal fistula and the number of treatment mechanisms,were not associated with fatigue across the total patient cohort.CONCLUSION DTT-CD,predominantly marked by complex perianal disease,is highly prevalent in these patients.Elevated IL-5 and IL-10 suggest a distinct immunophenotype in Chinese DTT-CD patients.Fatigue is associated with specific clinical features in DTT-CD patients. 展开更多
关键词 Difficult-to-treat Inflammatory bowel disease Fatigue Crohn’s disease Cross-sectional study
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A GATED SERVICE SINGLE VACATION M/G/1 QUEUE SYSTEM WITH SETUP AND CLOSEDOWN TIMES AND DIFFERENT CUSTOMER ARRIVAL RATES 认领 引用
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作者 Ying SUN Zhanyou MA Tongyu XU 《Acta Mathematica Scientia》 SCIE CSCD 2026年第1期407-426,共20页
A gated service single vacation M/G/1 queue with setup and closedown periods,and different customer arrival rates,is studied in this paper.The probability generating function of the number of systems for customers who... A gated service single vacation M/G/1 queue with setup and closedown periods,and different customer arrival rates,is studied in this paper.The probability generating function of the number of systems for customers who are at the initial moment of service period is analyzed by using a total probability theorem,and the stability condition of the system is obtained.The stationary distribution of the queue length is solved by the regeneration cycle method.The stochastic decomposition of queue length in the steady state is calculated,and the service cycle is obtained.Moreover,classified discussions are established in order to solve the steady-state distribution for the waiting time.The variation of system performance indicators with parameters is analyzed by performing numerical experiments. 展开更多
关键词 different arrival rates regeneration cycle method stochastic decomposition theorem stationary queue length
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One-dimensional(C12H12N)3Cu3I6for high-performance direct X-ray detection 认领 引用
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作者 Pan Gao Qingzheng Kong +8 位作者 Ying Sun Qian Ma Qi Wang Zeyu Guo Ledi Li Bingbing Li Jingwei Xu Xiaomei Jiang Zhaolai Chen 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2026年第1期61-67,共7页
X-ray detectors,as crucial elements in medical imaging and industrial fields,can be categorized into direct and indirect types.Direct detectors,which directly convert X-ray photons into electrical signals,exhibit high... X-ray detectors,as crucial elements in medical imaging and industrial fields,can be categorized into direct and indirect types.Direct detectors,which directly convert X-ray photons into electrical signals,exhibit high sensitivity and low detection limits,enabling the capture of high-resolution images and reducing radiation exposure to patients.Organic copper halides,recognized as potential active materials for X-ray detection,have been widely explored in the indirect scintillation field but remain under-explored in direct X-ray detector applications.In this work,(C12H12N)3Cu3I6is demonstrated as an efficient semiconductor for direct X-ray detection with excellent stability.A lateral-structured X-ray detector was fabricated with gold electrodes,which exhibits a maximum sensitivity of 1464.14μC·Gy-1·cm-2,a lowest detection limit of 19.8 nGy·s-1,a high on-off ratio of 2140,and an excellent operational stability of retaining 96%performance after 600 s continuous X-ray radiation.Furthermore,the detector successfully imaged a 0.1 mm“F”-shaped lead sheet,validating its capacity for X-ray imaging.This study highlights the potential of(C12H12N)3Cu3I6as a promising semiconductor for high-performance direct X-ray detection,expanding the application scope of organic copper halides in this critical field. 展开更多
关键词 Organic copper halides One-dimensional structure X-ray detection X-ray imaging
Information encryption with a high information-carrying capacity based on a stimulus-responsive hydrogen-bonded organic framework and a smartphone 认领 引用 被引量：1
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作者 Tianran Lin Chunsuo Tian +4 位作者 Ying Sun Shendong Liu Di Wang Li Hou Shulin Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期393-396,共4页
Information-carrying capacity has become an important factor in the development of encryption and anti-counterfeiting.Herein,a hydrogen-bonded organic framework(HOF-PyTTA)was developed as novel anti-counterfeiting ink... Information-carrying capacity has become an important factor in the development of encryption and anti-counterfeiting.Herein,a hydrogen-bonded organic framework(HOF-PyTTA)was developed as novel anti-counterfeiting ink without rare metals and a smartphone-based APP was written for encryption and anti-counterfeiting.We found that the fluorescence of HOF-PyTTA can be quenched by Fe3+ions and recovered by the addition of ascorbic acid.And the fluorescence of HOF-PyTTA can be enhanced by the increasing concentrations of ethanol.Based on these stimulus-response properties,four anti-counterfeiting models with gradually increased security were studied.Mode one was printed by HOFs ink and decrypted by UV light.Mode two was based on HOF-PyTTA and CsPbBr3inks(or HOF-PyTTA-Fe3+)which are used to separately print the genuine and pirated information.A decryption reagent was applied to get the genuine information.Furthermore,we successfully construct a dynamic information encryption anti-counterfeiting model using a fluorescence array in combination with an information encryption anticounterfeiting APP.The circular array is printed by several concentrations of HOF-PyTTA ink and different RGB thresholds are set with the help of the information encryption anti-counterfeiting APP,to obtain distinct encrypted anti-counterfeiting information,thus accomplishing a high information-carrying capacity. 展开更多
关键词 Hydrogen-bonded organic framework Fluorescence array Smartphone Anti-counterfeiting Message encryption
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糖酵解重编程与乳酸化串扰在肿瘤中的研究进展 认领 引用
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作者 冯祎琳 孙颖 +7 位作者 郝旭 杨慧彤 禄安琪 刘源 夏金婵 冯龙 蒋敏 赵西茹 《中国肺癌杂志》 CAS CSCD 北大核心 2026年第1期59-67,共9页
代谢重编程是癌症的核心特征,其中Warburg效应驱动的有氧糖酵解导致肿瘤微环境中乳酸大量积累。长期以来,乳酸被视为代谢终产物,然而近年研究发现,它作为一种重要的信号分子,通过诱导新型翻译后修饰——乳酸化修饰,深刻影响肿瘤进程。... 代谢重编程是癌症的核心特征,其中Warburg效应驱动的有氧糖酵解导致肿瘤微环境中乳酸大量积累。长期以来,乳酸被视为代谢终产物,然而近年研究发现,它作为一种重要的信号分子,通过诱导新型翻译后修饰——乳酸化修饰,深刻影响肿瘤进程。乳酸化修饰由乳酸驱动,发生在组蛋白与非组蛋白上,受“writer”“eraser”和“reader”机制的精密调控,从而改变靶蛋白功能与基因表达。本综述系统探讨了糖酵解重编程与乳酸化之间存在的双向调控网络:一方面,糖酵解关键调控因子促进乳酸生成,进而提升乳酸化水平;另一方面,乳酸化又能反馈调节糖酵解关键酶的活性与表达,形成促癌正反馈循环。这一互作在肿瘤增殖、转移、DNA损伤修复及免疫逃逸中发挥核心作用。基于此,靶向乳酸生成、乳酸转运或乳酸化修饰过程本身,已成为极具潜力的抗肿瘤策略,并与免疫检查点抑制剂等现有疗法展现出协同前景。深入解析糖酵解-乳酸化轴将为开发新型肿瘤治疗手段提供重要理论基础。 展开更多
关键词 乳酸化修饰 糖酵解重编程 肿瘤微环境 免疫逃逸 靶向治疗
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Teaching Chinese as a Foreign Language:Experiential Teaching,Cultural Communication,Cultural Identity,and Teaching Innovation 认领 引用
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作者 Ying Sun Qiuyun Wang 《Journal of Contemporary Educational Research》 2026年第6期164-169,共6页
The steady advancement of international Chinese education has made the teaching of Chinese as a foreign language an important carrier for the external communication of Chinese culture.At this stage,college TCFL teachi... The steady advancement of international Chinese education has made the teaching of Chinese as a foreign language an important carrier for the external communication of Chinese culture.At this stage,college TCFL teaching generally focuses on language skill training while neglecting immersive cultural experience.The rigid teaching modes and fragmented cultural content prevent foreign learners from fully grasping the core connotation of Chinese culture and tend to form one-sided and stereotyped cultural perceptions.From the perspective of experiential teaching,this paper combines the characteristics of cross-cultural cognition and constructs an integrated in-class and out-of-class teaching model from three aspects:innovative classroom carriers,Chinese story narration,and extracurricular scenario immersion,so as to explore innovative paths for Chinese cultural communication in TCFL.The research verifies that immersive experiential teaching can break cross-cultural cognitive barriers and promote foreign learners’transformation from superficial cultural perception to in-depth value identification,providing practical references for the optimization of TCFL teaching and the international communication of Chinese culture. 展开更多
关键词 Teaching Chinese as a Foreign Language Experiential teaching Cultural communication Cultural identity Teaching innovation
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Distribution,species richness,and relative importance of different plant life forms across drylands in China 认领 引用 被引量：8
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作者 Shuran Yao Weigang Hu +16 位作者 Mingfei Ji Abraham Allan Degen Qiajun Du Muhammad Adnan Akram Yuan Sun Ying Sun Yan Deng Longwei Dong Haiyang Gong Qingqing Hou Shubin Xie Xiaoting Wang Jinzhi Ran Bernhard Schmid Qinfeng Guo Karl J.Niklas Jianming Deng 《Plant Diversity》 SCIE CAS CSCD 2025年第2期273-281,共9页
Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen... Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale. 展开更多
关键词 Drylands Environmental gradients Plant life forms Relative importance Species richness Threshold
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Effect of macrophage- to- myofibroblast transition on silicosis 认领 引用 被引量：3
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作者 Fei Geng Jingrou Xu +12 位作者 Xichen Ren Ying Zhao Yuhao Cai Yaqian Li Fuyu Jin Tian Li Xuemin Gao Wenchen Cai Hong Xu Zhongqiu Wei Na Mao Ying Sun Fang Yang 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第2期363-371,共9页
Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group deve... Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group developed using a HOPE MED 8050 dynamic automatic dusting system.Murine mac-rophage MH-S cells were randomly divided into a control group and an SiO2 group.The pathological changes in lung tissue were observed using hematoxylin and eosin(HE)and Van Gieson(VG)staining.The distribution and location of macrophage marker(F4/80),M1 macrophage marker(iNOS),M2 macrophage marker(CD206),and myofibroblast marker(α-smooth muscle actin[α-SMA])were detected using immu-nohistochemical and immunofluorescent staining.The expression changes in iNOS,Arg,α-SMA,vimentin,and type I collagen(Col I)were measured using Western blot.Results:The results of HE and VG staining showed obvious silicon nodule formation and the distribution of thick collagen fibers in the lung tissue of the silicosis group.Macrophage marker F4/80 increased gradually from 8 to 32 weeks after exposure to silica.Immunohistochemical and immunofluorescent staining results revealed that there were more iNOS-positive cells and some CD206-positive cells in the lung tissue of the silicosis group at 8 weeks.More CD206-positive cells were found in the silicon nodules of the lung tissues in the silicosis group at 32 weeks.Western blot analysis showed that the expressions of Inducible nitric oxide synthase and Arg protein in the lung tissues of the silicosis group were upregulated compared with those of the con-trol group.The results of immunofluorescence staining showed the co-expression of F4/80,α-SMA,and Col I,and CD206 andα-SMA were co-expressed in the lung tissue of the silicosis group.The extracted rat alveolar lavage fluid revealed F4/80+α-SMA+,CD206+α-SMA+,and F4/80+α-SMA+Col I+cells using immunofluorescence staining.Similar results were also found in MH-S cells induced by SiO2.Conclusions:The development of silicosis is accompanied by macrophage polarization and MMT. 展开更多
关键词 macrophage macrophage-to-myofibroblast transition silicosis
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Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking in Drosophila 认领 引用 被引量：1
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作者 Fangzhou Luo Luwei Sui +6 位作者 Ying Sun Zhixian Lai Chengcheng Zhang Gaoqun Zhang Bing Bi Shichao Yu Li Hua Jin 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第1期51-65,共15页
Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with vertebrates.In larvae,hematopoiesis primarily occurs in the lymph gland,wh... Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with vertebrates.In larvae,hematopoiesis primarily occurs in the lymph gland,which contains distinct zones,including the cortical zone,intermediate zone,medullary zone,and posterior signaling center(PSC).Rab1 is vital for membrane trafficking and maintaining the localization of cell adhesion molecules,yet its role in hematopoietic homeostasis is not fully understood.This study investigates the effects of Rab1 dysfunction on β-integrin trafficking within circulating hemocytes and lymph gland cells.Rab1 impairment disrupts the endosomal trafficking of β-integrin,leading to its abnormal localization on cell membranes,which promotes lamellocyte differentiation and alters progenitor dynamics in circulating hemocytes and lymph glands,respectively.We also show that the mislocalization of β-integrin is dependent on the adhesion protein DE-cadherin.The reduction of β-integrin at cell boundaries in PSC cells leads to fewer PSC cells and lamellocyte differentiation.Furthermore,Rab1 regulates the trafficking of β-integrin via the Q-SNARE protein Syntaxin 17(Syx17).Our findings indicate that Rab1 and Syx17 regulate distinct trafficking pathways for β-integrin in different hematopoietic compartments and maintain hematopoietic homeostasis of Drosophila. 展开更多
关键词 Hematopoiesis Lymphgland Rab1 Syntaxin 17 β-integrin Drosophila
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