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Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease 认领 引用 被引量：2
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作者 Jia Zhang Siqi He +10 位作者 Qiguo Xiao Weijie Jiang Bo Wang Jing Lu Hongfeng Gu Yajin Liao Zhi Wang Ying Xu Dan Wang Xiaoqing Tang Ling Qi 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4989-4999,共11页
Alzheimer's disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists.We have previously reported that mesenchymal stem cell-derived extracellular vesicles del... Alzheimer's disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists.We have previously reported that mesenchymal stem cell-derived extracellular vesicles delay retinal degeneration by exerting anti-inflammatory effects though the miR-146a-nuclear receptor subfamily 4 group A member 3 axis;however,it remains unclear how NR4A3 drives inflammation.Herein,we engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a to explore their possible neuroprotective effects and the underlying mechanisms in both cell and animal models of Alzheimer's disease.In HT22 cells co-cultured with lipopolysaccharide-induced RAW264.7/BV2 cells,extracellular vesicles overexpressing miR-146a significantly reduced the number of apoptotic cells and inhibited proinflammatory cytokine expression,nuclear factor(NF)-κB activation,and caspase-3/apoptosis regulator BAX signaling.These effects of extracellular vesicles overexpressing miR-146a were replicated in 5×FAD mice.In addition,extracellular vesicles overexpressing miR-146a inhibited the activation of microglia and astrocytes,reduced amyloid-βand phosphorylated tau expression,lowered the number of apoptotic cells in the hippocampus,and improved the cognitive function of these Alzheimer's disease model mice.Mechanistically,miR-146a negatively regulated the expression of nuclear receptor subfamily 4 group A member 3 and suppressed the expression of proinflammatory cytokines and nuclear factor-κB signaling.Furthermore,NR4A3 overexpression promoted nuclear factor-κB and proinflammatory cytokine expression as well as nuclear factor-κB signaling.The upregulation of NR4A3 and the inflammatory response was reversed by miR-146a overexpression.Finally,NR4A3 was identified as a transcriptional activator of nuclear factor-κB using chromatin immunoprecipitation polymerase chain reaction.Collectively,these findings indicate that extracellular vesicles overexpressing miR-146a may alleviate the progression of Alzheimer's disease by exerting anti-inflammatory effects via the NR4A3-nuclear factor-κB axis.They are thus a potential therapeutic candidate for the clinical treatment of neurodegenerative diseases. 展开更多
关键词 Alzheimer’s disease amyloid-β cognitive function mesenchymal stem cell-derived extracellular vesicles microglia miR-146a neuroinflammation neuroprotection nuclear factor-κB nuclear receptor subfamily 4 group A member 3(NR4A3)
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Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice 认领 引用 被引量：1
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作者 Liting Zhong Dashuang Yang +5 位作者 Xiu Han Haiyang Cheng Di Xu Wen Li Gong Chen Ying Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3854-3862,共9页
Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic di... Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic differentiation factor 1(NeuroD1 or ND1)overexpression in retinal Müller cells may repair the retina after optic nerve crush in mice.Adult mice were subjected to optic nerve crush followed by intravitreal AAV-7m8-GFAP-GFP-ND1 virus injection.Immunofluorescent staining,multi-electrode array recording,electroretinogram,and visual behavior tests were then performed to examine retinal and optic nerve structure and retinal function at various post-optic nerve crush and virus injection times.Western blot analysis and quantitative reverse transcription polymerase chain reaction were performed to explore the possible mechanisms.Compared with the control virus,specific overexpression of ND1 in Müller cells greatly improved the light responses of retinal ganglion cells and retinal neurons in optic nerve crush-injured mice as early as 1-2 weeks post-virus injection and lasted for up to 4 weeks.Neuronal survival in the ganglion cell layer and synaptic connections in the inner retina were slightly improved at 2 weeks;however,visual behavior,retinal ganglion cell survival,and optic nerve structure were not improved.ND1 transiently enhanced glial cell-derived neurotrophic factor expression in the optic nerve crush-injured retina but hardly inhibited retinal inflammation within 2 weeks.Together,our data indicate that ND1 overexpression in Müller cells improves retinal function in the optic nerve crush-injured retina,and suggest that its neuroprotective effect may be caused by enhanced glial cell-derived neurotrophic factor release. 展开更多
关键词 glial cell-derived neurotrophic factor inflammation Müller cell NeuroD1 optic nerve injury retinal ganglion cell synaptic connection
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TaPRR95 regulates wheat flowering time and yield partially by interacting with the CONSTANS-like protein 认领 引用
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作者 Xinxin Cheng Lijun Zhang +9 位作者 Ying Xu Yongchao Hao Peng Jiang Shams ur Rehman Shisheng Chen Lingrang Kong Shuxin Zhang Hongwei Wang Yan Zhao Guiping Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第7期3086-3089,共4页
Highlights·A TaPRR95-A haplotype reduces flowering time and increases grain yield in wheat.·Protein-protein interaction between TaPRR95-A and TaCOL16-D modulates the TaFT1-mediated flowering pathway.·A ... Highlights·A TaPRR95-A haplotype reduces flowering time and increases grain yield in wheat.·Protein-protein interaction between TaPRR95-A and TaCOL16-D modulates the TaFT1-mediated flowering pathway.·A validated functional marker enables rapid identification of the target haplotype and provides a practical tool for markerassisted selection in wheat breeding.As a staple cereal crop cultivated worldwide,common wheat(Triticum aestivum L.)accounts for approximately 35%of global dietary energy requirements(Sharma and Sharma 2025).However,agricultural yields are currently under significant pressure due to the combined impacts of anthropogenic climate change and geopolitical conflicts(Ortiz-Bobea et al.2021;Hultgren et al.2025),which threatens global food security.These challenges necessitate the urgent development of molecular breeding approaches to improve wheat production sustainably. 展开更多
关键词 taprr validated functional marker identification target haplotype flowering time constans protein yield markerassisted selection protein protein interaction
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Lycium barbarum glycopeptide and luteolin synergistically protect mouse photoreceptors against N-nitroso-N-methylurea-induced degeneration 认领 引用
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作者 Xiu Han Qihang Kong +4 位作者 Yajing Liu Xuesong Mi Shibo Tang Kwok-Fai So Ying Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3202-3208,共7页
Photoreceptor degeneration is a major cause of vision impairment in retinal diseases,for which no effective treatment currently exists.Previous research by our team demonstrated that Lycium barbarum glycopeptide and l... Photoreceptor degeneration is a major cause of vision impairment in retinal diseases,for which no effective treatment currently exists.Previous research by our team demonstrated that Lycium barbarum glycopeptide and luteolin can independently promote photoreceptor survival and function in degenerated mouse retinas,although with limited efficacy.This study evaluated whether a combination of Lycium barbarum glycopeptide and luteolin provides enhanced therapeutic benefits compared with either compound alone.Wild-type mice received a daily oral gavage of Lycium barbarum glycopeptide and luteolin for 7 days prior to intraperitoneal injection of N-nitroso-N-methylurea to induce photoreceptor damage.The treatment continued for an additional week after injury.Retinal structure and function were subsequently assessed using electroretinogram recordings,visual behavior testing,and immunostaining.Western blot analysis was conducted to investigate the underlying protective mechanisms.The results showed that the Lycium barbarum glycopeptide-luteolin mixture significantly increased photoreceptor survival,improved retinal light response,and enhanced visual behavior.Importantly,the combination outperformed either compound alone in protective efficacy.Mechanistic analysis indicated that the mixture suppressed retinal inflammation and modulated the extracellular signal-regulated kinase and Bcl-2-associated X protein/B-cell lymphoma 2 signaling pathways.These findings suggest that the combination of Lycium barbarum glycopeptide and luteolin represents a promising therapeutic strategy for photoreceptor degeneration. 展开更多
关键词 inflammation inherited retinal diseases luteolin Lycium barbarum glycopeptide N-nitroso-N-methylurea photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa wolfberry extract
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Catalytic depolymerization of organic extraction pine lignin over Ni/MLG coupled with NaOH for aromatic monomer production 认领 引用
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作者 Ying Xu Meiziya Gong +3 位作者 Lie Zhou Yuanbo Huang Xiaodong Zhang Riyang Shu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第6期249-258,共10页
In order to advance the development of biomass energy chemical field and to increase the utilization efficiency of lignin for valuable chemicals,this study explored the whole process from lignin extraction to depolyme... In order to advance the development of biomass energy chemical field and to increase the utilization efficiency of lignin for valuable chemicals,this study explored the whole process from lignin extraction to depolymerization using pine wood flour as raw material for the production of aromatic monomers.The efficient extraction of lignin from pine wood flour was achieved in 1,4-butanediol solvent at 170℃,which then was converted to aromatic monomers successfully under the synergistic catalysis of Ni/MLG and NaOH.The usage of 1,4-butanediol extracting pine flour lignin enables to protect the guaiacyl(G)units and prevent the recombination of C―C bonds in the lignin fragments.And the synergistic effect of Ni/MLG and NaOH catalysts can efficiently hydrogenolyze not only lignin feedstock but also lignin oligomer fragments into aromatic monomers,enhancing the yield significantly.As a result,97.5%lignin conversion and 36.9%yield of aromatic monomers are obtained at 280℃,with the carbon deposition rate below 6.7%,which is much superior to other Ni-based carbon catalysts and other alkaline catalysts.The major aromatic monomers include guaiacols,syringols,and p-hydroxyphenols,and they are promising for subsequent product purification and application as high value chemicals.This study not only proposes an effective way for the utilization of lignin,but also provides valuable reference for the development of biomass energy chemical field. 展开更多
关键词 Biomass Catalysis Hydrogenation Lignin Aromatic monomers
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Association between polycyclic aromatic hydrocarbons exposure and gestational hypertension:Insights from global and dose metabolomics analysis 认领 引用
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作者 Jin Chen Yiwei Fang +4 位作者 Borui Sun Ying Xu Wanyi Chen Kai Zhao Huiping Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第3期658-665,共8页
Polycyclic aromatic hydrocarbons(PAHs)are widespread pollutants from incomplete combustion of organic materials,linked to various health issues and pregnancy complications.This study explored the relationship between ... Polycyclic aromatic hydrocarbons(PAHs)are widespread pollutants from incomplete combustion of organic materials,linked to various health issues and pregnancy complications.This study explored the relationship between PAH metabolites and gestational hypertension.Urine samples from 118 normal pregnant women and 40 with gestational hypertension were analyzed.In vitro experiments using human trophoblast cells(HTR-8/SVneo)exposed to these metabolites assessed their effects on cellular metabolism.Comprehensive metabolomics analysis was performed using Tidymass and DRomics to integrate global and dose-response metabolomics data.Results showed higher levels of 1-hydroxypyrene(1-OHPYR)and 9-Hydroxyphenanthrene(9-OHPHE)linked to gestational hypertension,inhibiting trophoblast cell invasion and migration.Identified markers include Isobutyryl-L-carnitine,methyl-3-hydroxybutyric acid,threonine,and glutamic acid for 1-OHPYR,and phosphocreatine for 9-OHPHE.This study highlights the connection between PAH metabolites and gestational hypertension,suggesting potential biomarkers and mechanisms.Future research should confirm these findings and explore prevention and treatment strategies. 展开更多
关键词 Polycyclic aromatic hydrocarbons Gestational hypertension Dose-response 1-hydroxypyrene 9-Hydroxyphenanthrene
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Dynamics of a two-disk dynamo loaded with a dual neuron circuit and its application 认领 引用
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作者 Fuqiang WU Ying XU +1 位作者 Huimin QI Jun MA 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第7期762-778,I0057-I0060,共17页
Constructing a neuromorphic electromechanical system based on a flexible memristor is of great significance for the development of biomimetic electrical-mechanical transverters.A bioinspired electromechanical system c... Constructing a neuromorphic electromechanical system based on a flexible memristor is of great significance for the development of biomimetic electrical-mechanical transverters.A bioinspired electromechanical system can perform real-time energy-efficient processing of multimodal signals,including electrical activities and mechanical motions.Here,we propose a bioinspired electromechanical system composed of a two-disc dynamo driven by a dual integrate-and-fire neuron.A memristive system exists in the bioinspired electromechanical system,as observed in the current-voltage relationship.The neuromorphic electromechanical model can exhibit a multiscroll hidden attractor by adjusting a controllable parameter.Complex chaotic behaviors have been demonstrated by numerical simulations,including two-parameter bifurcation,Lyapunov exponents,and phase diagrams.Finally,the applicability of a chaotic encryption scheme is successfully implemented on a neuromorphic electromechanical system. 展开更多
关键词 Nonlinear dynamics Neuron Chaotic model Electromechanical system Memristor Encryption
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Synergistic delay and strength tuning for logical operations in a chaotic neuron 认领 引用
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作者 Ying Xu 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第6期166-174,共9页
An improved FitzHugh–Nagumo neuron model is proposed,incorporating electromagnetic induction via a fluxcontrolled memristor and dual autaptic feedback with tunable strengths and delays.This brain-inspired unit can re... An improved FitzHugh–Nagumo neuron model is proposed,incorporating electromagnetic induction via a fluxcontrolled memristor and dual autaptic feedback with tunable strengths and delays.This brain-inspired unit can reliably perform AND and OR logic operations under chaotic driving,serving as a tunable nonlinear computing element.Systematic numerical analysis reveals that the synergistic interplay between autaptic delays and strengths plays a key role in achieving optimal logical stochastic resonance.Specifically,the system achieves near-perfect success rates within specific parameter regions,where a compensatory effect enables delay asymmetry to balance synaptic strength mismatch.Furthermore,at lower coupling strengths,a multiple logical resonance phenomenon is observed,in which the success probability exhibits multiple peaks as a function of synaptic delay.This work not only elucidates the dynamical mechanism underlying reliable neuronal logic operation but also provides a co-design principle for tuning neuromorphic circuits,with potential implications for low-power,high-flexibility computing hardware. 展开更多
关键词 FitzHugh–Nagumo neuron model memristor multi-scale autapse logical resonance time delay
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Composition and Function of Bacterial Communities of Bryophytes and Their Underlying Sediments in the Dajiuhu Peatland, Central China 认领 引用 被引量：2
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作者 Xing Xiang Hongmei Wang +4 位作者 Wen Tian Ruicheng Wang Linfeng Gong Ying Xu Baiying Man 《Journal of Earth Science》 SCIE CAS CSCD 2023年第1期133-144,共12页
Symbiotic microbiomes of Sphagnum have been confirmed to play a fundamental role in carbon and nitrogen cycles, however, little is known about microbiomes associated with other bryophytes in subtropical peatland ecosy... Symbiotic microbiomes of Sphagnum have been confirmed to play a fundamental role in carbon and nitrogen cycles, however, little is known about microbiomes associated with other bryophytes in subtropical peatland ecosystems. To explore the differences in community structure, metabolic potential and interaction relationship of bacterial microbiomes associated with different bryophytes species, the gametophytes of three bryophyte species(Sphagnum palustre, Aulacomnium androgynum, and Polytrichum commune) and their underlying peat sediments were collected from the subtropical Dajiuhu Peatland and subjected to Illumina high-throughout sequencing of 16S r RNA gene. Results showed that bacterial diversity was lowest in S. palustre, the dominant moss species, among the three moss species investigated in Dajiuhu Peatland. Bacterial communities from bryophytes clearly separated with those from sediments as indicated by both phylogenetic and taxonomical approaches. Linear discriminant analysis effect size(LEf Se) identified 30 and 36 indicator taxa in mosses and peat sediments. Bacteroidetes, Verrucomicrobia and Thermoleophilia significantly enriched in S. palustre, A. androgynum and P. commune, Chloroflexi, Proteobacteria and Acidobacteria subgroup 6 was indicator taxa for corresponding underlying sediments, respectively. Despite of these differences in compositions, bacterial functional structures were similar among all bryophytes, such as abundant aerobic heterotrophs, rare nitrifiers and denitrifiers. This phenomenon was also observed among the underlying sediments. Network analysis indicated that Proteobacteria and Acidobacteria located in the center of network and exerted strong interactions to other taxa. The sub-network of bacterial communities in sediments was more connected and microbial groups were more competitive than those in bryophytes subnetwork. Our results offer new insight into the community structure, ecological function and interaction pattern of bacterial microbiomes in the Dajiuhu Peatland across different habitats. 展开更多
关键词 bryophytes bacteria bacterial microbiome indicator taxa co-occurrence network the Dajiuhu Peatland
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The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines 认领 引用
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作者 Xuan Lin Hongguang Xiang +7 位作者 Jiong Wu Ruixi Liao Yuhao Li Bohui Xu Ying Xu Yan Shen Qian Li Yu Tian 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2026年第1期75-108,共34页
Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers, rare diseases... Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers, rare diseases, and infectious diseases. However, their clinical application faces challenges. These include high molecular weight, limited cellular uptake,and susceptibility to enzymatic degradation by nucleases in vivo. Both viral and non-viral delivery vectors have been developed as a means of addressing these limitations, including lipid nanoparticles(LNPs), exosomes, polymers, and inorganic nanoparticles. Among these,LNPs have garnered significant attention due to their superior biocompatibility, high delivery efficiency and customizable design potential, as demonstrated by the clinical success of the FDA-approved si RNA drug Onpattro®. The critical role of nucleic acid drug carriers is discussed in this review. It also outlines the major types of carriers under development and examines the advancements and applications in LNP-based systems for nucleic acid delivery. By conducting a review of recent advancements in LNP design, delivery mechanisms, and clinical applications, this article aims to clarify the ways in which LNPs overcome delivery barriers, compare LNPs with other carriers, and identify key trends that can inform the development of next-generation LNP platforms for nucleic acid therapeutics. 展开更多
关键词 Nucleic acid therapeutics Nucleic acid drugs Delivery systems Nucleic acid delivery challenges Lipid nanoparticle carriers
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Ginsenoside CK inhibits melanoma growth by promoting apoptosis and targeting cGAS-STING pathway to regulate the immune microenvironment 认领 引用
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作者 Haodong Tang Ying Xu +3 位作者 Rongzhan Fu Zhiguang Duan Chenhui Zhu Daidi Fan 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2143-2155,共13页
Malignant melanoma,the 19th most prevalent cancer globally,is the primary cause of mortality attributed to cutaneous malignancies.Ginsenoside compound K(CK),a rare ginsenoside renowned for its potent medicinal propert... Malignant melanoma,the 19th most prevalent cancer globally,is the primary cause of mortality attributed to cutaneous malignancies.Ginsenoside compound K(CK),a rare ginsenoside renowned for its potent medicinal properties and established safety profile,is widely employed in the treatment and prevention of various diseases.This study aimed to investigate the influence of CK on cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)pathway in melanoma,particularly its effects on apoptosis and the immune microenvironment,with the ultimate goal of impeding melanoma growth.In the present study,we used a subcutaneous hormonal tumor model in homozygous mice to investigate whether CK has an inhibitory effect on melanoma growth.The effect of CK on melanoma cell apoptosis was analyzed by flow cytometry,immunohistochemistry,hematoxylin and eosin staining,protein immunoblotting,and RT-qPCR were used to observe the effect of CK on melanoma cytokines.The effects of CK on cGAS-STING pathway in melanoma cells were investigated by protein immunoblotting,immunofluorescence,flow cytometry and molecular docking.The findings demonstrate that CK effectively suppresses melanoma cell proliferation.Molecular docking analysis revealed a binding energy of-6.59 kcal/mol between CK and STING,indicating the potential of CK as a targeted regulator of STING.Mechanistically,CK induces apoptosis in melanoma cells through the Caspase pathway and enhances STING-mediated regulation of the immune microenvironment via the cGAS-STING pathway,thereby inhibiting melanoma growth Notably,our study provides the first evidence that CK acts as an immune checkpoint agonist,elevating T lymphocyte levels within tumors.CK promotes apoptosis through the Caspase pathway,regulates the cGAS-STING pathway,promotes the production of IFN-βand chemokines by the nucleus,and promotes the infiltration of T-cells in the tumor microenvironment,thus achieving the inhibition of melanoma. 展开更多
关键词 Ginsenoside compound K STING Apoptosis Melanoma CD8+T cell Tumor immune microenvironment
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In situ engineered organic-inorganic bilayer solid electrolyte interphase enabling lithium metal batteries over 15,000-h lifespan 认领 引用
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作者 Bin Zhang Ke Yue +6 位作者 Ke Wang Guohao Zhao Wenbin Huang Tao Li Jianmin Luo Ying Xu Xinyong Tao 《eScience》 SCIE CSCD 2026年第4期119-129,共11页
Despite significant advancements in constructing LiF-rich solid electrolyte interphases(SEIs)for highperformance lithium(Li)metal batteries,reconciling high ionic conductivity,mechanical resilience,and longterm interf... Despite significant advancements in constructing LiF-rich solid electrolyte interphases(SEIs)for highperformance lithium(Li)metal batteries,reconciling high ionic conductivity,mechanical resilience,and longterm interfacial stability persists as a critical challenge.Current approaches often fail to ensure seamless integration with the Li anode or else compromise electrolyte stability.Here,we present a dynamic in situ selfreinforcing SEI architecture achieved via selective fluorination using 1-fluorooctane,which spontaneously constructs a hybrid organic—inorganic bilayer structure during cycling.The flexible outer organic layer enhances electrolyte compatibility,while the LiF-rich inner layer ensures robust mechanical strength and promotes uniform Li-ion flux,effectively inhibiting Li dendrite growth.With these synergistic effects,the bilayer SEI provides an ultra-stable interphase with homogeneous Li deposition,yielding record-long lifespans exceeding 15,000 h at 1 mA cm-2and nearly 15,000 h at 25 mA cm-2in symmetric Li cells,far surpassing prior reported LiF-based Li anodes.LiFePO4||Li pouch cells(with a high mass loading of 7.8 mg cm-2and 50μm thin Li foil)retain 80%capacity over 250 cycles at 0.5 C,demonstrating exceptional stability and practical application potential.The proposed in situ fabricated LiF-rich organic—inorganic bilayer SEI offers new perspectives to guide the practical application of high-performance Li metal batteries. 展开更多
关键词 1-fluorooctane Organic-inorganic dual-structured SEI LiF-rich In situ fabrication Li metal anode
Li7La3Zr2O12/Polymethacrylate-Based Composite Electrolyte with Hybrid Solid Electrolyte Interphase for Ultra-stable Solid-State Lithium Batteries 认领 引用
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作者 Tao Li Guohao Zhao +5 位作者 Zhiyi Zhao Yaqi Xu Tianli Wu Dong‑Liang Peng Qingshui Xie Ying Xu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第6期336-349,共14页
Li7La3Zr2O12-based electrolytes have got great promise for solid-state lithium(Li)metal batteries because of their high elastic modulus and wide electrochemical stability window.However,the insufficient co... Li7La3Zr2O12-based electrolytes have got great promise for solid-state lithium(Li)metal batteries because of their high elastic modulus and wide electrochemical stability window.However,the insufficient contact and heterogeneous Li deposition severely hinder their practical applications.Here,a flexible ternary polymethacrylate(PMA)matrix is designed to incorporate with Ta-doped Li7La3Zr2O12(LLZTO-PMA).The PMA matrix ensures excellent interfacial contact,while the synergistic effects of its polar carbonyl groups and its interaction with LLZTO creating fast interfacial Li+pathways yield a high ionic conductivity of 0.266 mS cm-1at 20℃.Moreover,the interaction between LLZTO and PMA matrix further guides the formation of a hybrid LiF/Li3N-rich solid electrolyte interphase,which allows a fast Li+interfacial kinetic due to its lowered Li+diffusion barrier.Consequently,the LLZTO-PMA electrolyte contributes an ultra-stable Li anode interphase,attaining a lifespan exceeding 10,000 h in symmetric cells and retaining over 96%capacity after 600 cycles in full battery,demonstrating a breakthrough for high-performance solid-state batteries. 展开更多
关键词 LLZTO Ionic conductivity Li3N-LiF hybrid SEI Stable interphase Solid-state Li batteries
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Controllable dual longitudinal optical particle trapping via astigmatic non-uniform coherence engineering 认领 引用
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作者 Mulin Yu Jidong Wu +4 位作者 Jiayi Yu Yangjian Cai Fei Wang Xinlei Zhu Ying Xu 《Chinese Optics Letters》 SCIE EI CAS CSCD 2026年第6期146-151,共6页
In this study,we achieve stable and precisely controllable dual longitudinal optical potential wells using structured random beams via astigmatic non-uniform coherence engineering.By embedding astigmatic phase modulat... In this study,we achieve stable and precisely controllable dual longitudinal optical potential wells using structured random beams via astigmatic non-uniform coherence engineering.By embedding astigmatic phase modulation into a random beam with a spatially varying coherence state,it is not only able to generate dual longitudinal potential wells with enhanced confinement,but also preserves this dual-potential-well feature and the characteristics of the radiation force distribution in a wide range of spatial coherence length,even at higher coherence levels.The radiation forces,stiffness,and trap range generated by such structured random beams are thoroughly investigated through numerical examples.The interplay between astigmatism and coherence enables tunable trap positions,confinement ranges,and potential well stiffness,offering refined control over particle trapping.These findings provide,to our knowledge,a new strategy to overcome the stability limitations of coherence-structured optical tweezers and advance longitudinal optical manipulation. 展开更多
关键词 optical coherence spatial coherence structure optical trapping.
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The Impacts of Climate Change on the Environment and Human Health in China:A Call for more Ambitious Action 认领 引用 被引量：2
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作者 Shilu Tong Yu Wang +11 位作者 Yonglong Lu Cunde Xiao Qiyong Liu Qi Zhao Cunrui Huang Jiayu Xu Ning Kang Tong Zhu Dahe Qin Ying Xu Buda Su Xiaoming Shi 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第2期127-143,共17页
As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever before.China is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate c... As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever before.China is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate change.The evidence about the impacts of climate change on the environment and human health may encourage China to take more decisive action to mitigate greenhouse gas emissions and adapt to climate impacts. 展开更多
关键词 change greenhouse climate
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A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates 认领 引用
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作者 Zhi‑Qiang Xiao Xiu Han +9 位作者 Xin Ren Zeng‑Qiang Wang Si‑Qi Chen Qiao‑Feng Zhu Hai‑Yang Cheng Yin‑Tian Li Dan Liang Xuan‑Wei Liang Ying Xu Hui Yang 《Neuroscience Bulletin》 SCIE CAS CSCD 2025年第5期911-916,共6页
Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve ... Dear Editor,Traumatic optic neuropathy(TON)is a severe vision-threatening condition,with an incidence rate ranging from 0.7% to 2.5%[1].The limited regenerative capacity of the optic nerve and the challenges of nerve transplantation result in substantial and irreversible visual loss in patients with TON. 展开更多
关键词 traumatic optic neuropathy non human primates vision threatening condition anterior orbital approach optic nerve transplantation optic neuropathy ton nerve transplantation optic nerve
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Effect of solute elements(B,C,N,O)onγ-FeΣ5(210)[001]grain boundary:a first-principles study 认领 引用
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作者 Ying Xu Ya-nan Xu +3 位作者 Wei-gang Cao Xin Meng Fu-cheng Zhang Xiao-mei Lv 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第6期1716-1724,共9页
Second period elements(B,C,N,and O)usually appear at the grain boundary(GB)and strongly affect the mechanical performance in austenitic stainless steels.Therefore,it is significant to investigate the effect of solute ... Second period elements(B,C,N,and O)usually appear at the grain boundary(GB)and strongly affect the mechanical performance in austenitic stainless steels.Therefore,it is significant to investigate the effect of solute elements(B,C,N,and O)on the GB.The first-principles calculation based on the density function theory was applied to explore the effect of B,C,N,and O onγ-FeΣ5(210)[001]GB.The GB energy,the segregation energy,the Voronoi volume,and the theoretical tensile test were calculated to investigate the segregation behavior and the strengthening effect.The structural change and electronic evolution were also investigated by bond change,charge density distribution,and density of states.The results show that B is favored to segregate at the capped trigonal prism(CTP)position with a large void and has a strengthening effect on the GB strength,while O and N are preferred to locate at the octahedral(OCT)site and have an embrittling effect on GB cohesion.C can segregate at both the CTP site and the OCT location with little energy difference.As C segregates at the OCT site,it is beneficial for GB strength.However,it is detrimental at the CTP position.It can be seen that the influence of solutes is closely related to the element type and segregated position. 展开更多
关键词 First-principles calculation Grain boundary Solute effect γ-Fe Electronic evolution
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A comprehensive review of small molecule drugs approved by the FDA in 2024:Advance and prospect 认领 引用
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作者 Yi-Ru Bai Qing-Chuan Duan +7 位作者 Dong-Jie Seng Ying Xu Hong-Bo Ren Jie Zhang Dan-Dan Shen Li Yang Hong-Min Liu Shuo Yuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第10期94-108,共15页
In 2024,the U.S.Food and Drug Administration approved a total of 50 drug marketing applications,with small molecule drugs accounting for half of the medications.Upon surveying these endorsed pharmaceuticals,it becomes... In 2024,the U.S.Food and Drug Administration approved a total of 50 drug marketing applications,with small molecule drugs accounting for half of the medications.Upon surveying these endorsed pharmaceuticals,it becomes evident that certain structures exhibit familiarity,potentially resulting from structural modifications applied to previously approved drugs.Consequently,exploring the latest advancements in drug research not only aids comprehension of cutting-edge technologies used in drug development but also fosters invaluable experience and knowledge accumulation while nurturing innovative ideas for future drug discovery.This review comprehensively analyzes the research progress related to approved small molecule drugs,including aspects such as drug design,structural modification,activity enhancement,and druggability improvement.The aim is to provide valuable insights and assistance for researchers in pharmacology. 展开更多
关键词 Drug design Mechanism of action Molecular docking Structure-activity relationship Pharmacokinetic properties
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Quantitative Detection of Micro Hole Wall Roughness in PCBs Based on Improved U-Net Model 认领 引用
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作者 Lijuan Zheng Yonghao Li +5 位作者 Zhuangzhuang Sun Yangquan Luo Ying Xu Jun Wang Chengyong Wang Xin Wei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2025年第3期1-11,共11页
The current method for inspecting microholes in printed circuit boards(PCBs)involves preparing slices followed by optical microscope measurements.However,this approach suffers from low detection efficiency,poor reliab... The current method for inspecting microholes in printed circuit boards(PCBs)involves preparing slices followed by optical microscope measurements.However,this approach suffers from low detection efficiency,poor reliability,and insufficient measurement stability.Micro-CT enables the observation of the internal structures of the sample without the need for slicing,thereby presenting a promising new method for assessing the quality of microholes in PCBs.This study integrates computer vision technology with computed tomography(CT)to propose a method for detecting microhole wall roughness using a U-Net model and image processing algorithms.This study established an unplated copper PCB CT image dataset and trained an improved U-Net model.Validation of the test set demonstrated that the improved model effectively segmented microholes in the PCB CT images.Subsequently,the roughness of the holes’walls was assessed using a customized image-processing algorithm.Comparative analysis between CT detection based on various edge detection algorithms and slice detection revealed that CT detection employing the Canny algorithm closely approximates slice detection,yielding range and average errors of 2.92 and 1.64μm,respectively.Hence,the detection method proposed in this paper offers a novel approach for nondestructive testing of hole wall roughness in the PCB industry. 展开更多
关键词 PCB CT image segmentation Improved U-Net model Hole wall roughness Micro-CT non-destructive testing
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High-Pressure Phase Transitions and Mechanisms in Lanthanum Mononitride 认领 引用
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作者 Hao Chen Dan Zhou +1 位作者 Ying Xu Quan Li 《Chinese Physics Letters》 SCIE EI CAS CSCD 2025年第6期163-169,共7页
A longstanding discrepancy between theoretical predictions and experimental observations on the highpressurestructural transformations of lanthanum mononitride(LaN)has posed challenges for understandingthe behavior of... A longstanding discrepancy between theoretical predictions and experimental observations on the highpressurestructural transformations of lanthanum mononitride(LaN)has posed challenges for understandingthe behavior of heavy transition metal mononitrides.Here,we systematically investigate the structural evolutionof LaN under high pressure using first-principles calculations combined with angle-dispersive synchrotron X-raydiffraction,identifying the phase transition sequence and corresponding phase boundaries.Analyses of energetics,kinetic barriers,and lattice dynamics reveal distinct mechanisms driving these transitions.These results clarifythe structural stability of LaN and offer guidance for studying other heavy transition metal mononitrides withcomplex electronic behavior under extreme conditions. 展开更多
关键词 phase transition sequence understandingthe behavior heavy transition metal mononitridesherewe high pressure phase transitions lanthanum mononitride theoretical predictions lattice dynamics structural stability lanthanum mononitride lan
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