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Fluorination Engineering for Stable Interfacial Chemistry in Deep Eutectic Amide-Based Electrolytes Enables High-Performance LiNi0.8Co0.1Mn0.1O2/Li Batteries 认领 引用
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作者 Yuanxin Gao Xinyi Wang +10 位作者 Dong Lv Zhang Zhang Jiangpeng Li Xiaoyan Feng Jingchao Chai Yun Zheng Yu Peng Yanqing Wang Yingying Wang Lingyu Zhu Zhihong Liu 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2026年第2期244-254,共11页
Fluorinated amide electrolytes represent a promising solution for high-energy density lithium metal batteries,yet their application in Ni-rich layered oxide cathodes is hindered by interfacial instability.This study d... Fluorinated amide electrolytes represent a promising solution for high-energy density lithium metal batteries,yet their application in Ni-rich layered oxide cathodes is hindered by interfacial instability.This study develops a nonflammable fluorinated amide-based deep eutectic electrolyte modified with fluoroethylene carbonate,which simultaneously enhances ionic conductivity(1.5×10-4 S cm-1)and anodic stability(>4.4 V vs Li+/Li).Applied in Li/NCM811 batteries,the fluoroethylene carbonate-based electrolyte enables 83.2%capacity retention after 200 cycles at 0.5 C,significantly outperforming conventional counterparts.ToF-SMIS and XPS tests reveal that fluoroethylene carbonate facilitates the formation of a LiF-rich cathode-electrolyte interphase,suppressing parasitic reactions and improving Li+transport kinetics.Furthermore,the electrolyte demonstrates superior lithium metal compatibility,inhibiting dendrite growth while enhancing thermal safety.These findings underscore the critical role of fluorinated amide electrolytes in stabilizing Ni-rich cathodes and highlight their potential for next-generation high-voltage lithium metal batteries. 展开更多
关键词 fluoroamide fluoroethylene carbonate lithium metal battery Ni-rich ternary cathode non-flammable
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Recent development in radical cycloaddition reactions for the synthesis of carbo-and heterocycles 认领 引用
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作者 Saima Perveen Lulu Qin +4 位作者 Min Zhao Zhengwei Ding Yingying Wang Zaicheng Nie Pengfei Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期57-91,共35页
Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and... Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry.Radical-mediated cycloaddition strategies,which recycle radical character,are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy.This review focuses on recent developments and synthetic applications in RCRs,with an emphasis on visible lightinduced radical photocycloaddition reactions(RPCRs),transition metal-catalyzed approaches,and small molecule-catalyzed methods.By highlighting some outstanding innovations and addressing current challenges,this review aims to identify potential areas for improvement.These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies. 展开更多
关键词 Radical cycloaddition Carbo-and heterocycle Visible-light photoaddition Transition metal catalysis Organic small molecule
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A Fine-Grained RecognitionModel based on Discriminative Region Localization and Efficient Second-Order Feature Encoding 认领 引用
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作者 Xiaorui Zhang Yingying Wang +3 位作者 Wei Sun Shiyu Zhou Haoming Zhang Pengpai Wang 《Computers, Materials & Continua》 SCIE EI 2026年第4期946-965,共20页
Discriminative region localization and efficient feature encoding are crucial for fine-grained object recognition.However,existing data augmentation methods struggle to accurately locate discriminative regions in comp... Discriminative region localization and efficient feature encoding are crucial for fine-grained object recognition.However,existing data augmentation methods struggle to accurately locate discriminative regions in complex backgrounds,small target objects,and limited training data,leading to poor recognition.Fine-grained images exhibit“small inter-class differences,”and while second-order feature encoding enhances discrimination,it often requires dual Convolutional Neural Networks(CNN),increasing training time and complexity.This study proposes a model integrating discriminative region localization and efficient second-order feature encoding.By ranking feature map channels via a fully connected layer,it selects high-importance channels to generate an enhanced map,accurately locating discriminative regions.Cropping and erasing augmentations further refine recognition.To improve efficiency,a novel second-order feature encoding module generates an attention map from the fourth convolutional group of Residual Network 50 layers(ResNet-50)and multiplies it with features from the fifth group,producing second-order features while reducing dimensionality and training time.Experiments on Caltech-University of California,San Diego Birds-200-2011(CUB-200-2011),Stanford Car,and Fine-Grained Visual Classification of Aircraft(FGVC Aircraft)datasets show state-of-the-art accuracy of 88.9%,94.7%,and 93.3%,respectively. 展开更多
关键词 Fine-grained recognition feature encoding data augmentation second-order feature discriminative regions
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New structures and properties of YF3and YF6under high pressure 认领 引用
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作者 Lebin Chang Jianlun Huang +2 位作者 Yuhao Fu Yingying Wang Jurong Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第3期81-88,共8页
Exploring new structures and properties of matter is a central topic in condensed matter physics.In this work,firstprinciples calculations and structure prediction methods were employed to investigate fluorine-rich yt... Exploring new structures and properties of matter is a central topic in condensed matter physics.In this work,firstprinciples calculations and structure prediction methods were employed to investigate fluorine-rich yttrium compounds.Two new stable phases,Pmmn-YF3and Amm2-YF6,have been identified under high pressure.Pmmn-YF3is stable over a pressure range of 50 GPa to 500 GPa,and Amm2-YF6remains stable at pressures beyond 429 GPa.Analysis of the band structure,density of states(DOS),and Bader charge for these two stable compounds reveals that Pmmn-YF3is an insulator and Amm2-YF6is a metal,elucidating their chemical bonding characteristics.F-F bond lengths and Bader charge analysis confirm the+3 oxidation state of yttrium in the molecular crystal YF3and the crystal structure YF6.Our work provides a valuable theoretical foundation for elucidating the properties of the rare earth transition metal yttrium. 展开更多
关键词 lattice dynamics first-principles theory solid-solid transitions crystallographic aspects of phase transformations pressure effects
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Identification and functional characterization of anaphase-promoting complex/cyclosome subunits in tomato 认领 引用
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作者 Ge Wang Peng Zhang +5 位作者 Yingying Wang Xuemei Zhang Di Ma Genzhong Liu Zhilong Bao Fangfang Ma 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期918-934,共17页
The anaphase-promoting complex/cyclosome(APC/C),a multiunit-E3 ligase,governs both mitotic and non-mitotic pathways by interacting with ubiquitinated proteins.However,developmental functions of APC/C subunits in tomat... The anaphase-promoting complex/cyclosome(APC/C),a multiunit-E3 ligase,governs both mitotic and non-mitotic pathways by interacting with ubiquitinated proteins.However,developmental functions of APC/C subunits in tomato have been rarely studied.Here,we identified a total of nine APC/C subunits in tomato genome and established their functions in leaf and fruit development via VIGS gene silencing technology.Protein interactions between subunits revealed that tomato'Heinz 1706'had a slightly different APC/C structure from other systems,in which APC8 and APC10 had the most interactions.Silencing APC/C subunits in tomato led to smaller plants with significantly reduced plant height,biomass,leaf area,flower size and fruit size.Cytological analyses confirmed that silencing APC/C subunits repressed both cell division and expansion in tomato leaves and fruits.Both flow cytometric and mitotic index analyses verified the positive role of APC/C in regulating M phase of cell cycle,which led to increased DNA contents in cells of silencing plants.APC1,APC2,APC4,APC11 and CDC27a had more impacts on the floral organ development than other subunits.Silencing APC/C subunits reduced the pollen viability due to unbalanced meiotic division.APC4 and APC6 were important for the fruit maturation while APC1,APC4 and APC10 modulated the fruit shape.Taken together,our findings illustrate that APC/C is essential for tomato development through the modulation of mitotic and meiotic division,and different subunits may have distinct or more profound impacts on the certain tissue development than others. 展开更多
关键词 Solanum lycopersicum APC/C VIGS Cell division Cell expansion Development
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Phosphotungstic Acid Modulated PNIPAM/P(AA-co-AM)Bilayer Hydrogels With Programmable Thermo-Responsive Kinetics and Enhanced Toughness 认领 引用
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作者 Hui Liu Hongli Jia +3 位作者 Xiaojin Yan Rouling Chen Yingying Wang Kun Chen 《Rare Metals》 SCIE EI CAS CSCD 2026年第5期485-498,共14页
Thermo-responsive hydrogels based on poly(N-isopropylacrylamide)(PNIPAM)are promising candidates for soft actuation,yet their practical applications are often constrained by sluggish thermo-responsive kinetics and ins... Thermo-responsive hydrogels based on poly(N-isopropylacrylamide)(PNIPAM)are promising candidates for soft actuation,yet their practical applications are often constrained by sluggish thermo-responsive kinetics and insufficient mechanical robustness.Herein,phosphotungstic acid(PTA),a tungsten-containing polyoxometalate,was incorporated to regulate the phase transition behavior and modulate a PNIPAM/P(AA-co-AM)bilayer hydrogel,in which the thermo-responsive PNIPAM layer serves as the actuator whereas the non-thermo-responsive P(AA-co-AM)layer provides mechanical support.By increasing the PTA content up to 4 wt%,the thermally induced deformation time of the PNIPAM layer was prolonged from 30 to 120 s,whereas the recovery time at low temperature was shortened from 120 to 60 min,thereby enabling programmable thermo-responsive kinetics.The thermal transition of the PTA-PNIPAM layer was effectively regulated by PTA,with the lower critical solution temperature(LCST)gradually increasing and tunable up to 42℃,accompanied by an improved thermal stability manifested by reduced mass loss at 150℃.Mechanical characterization demonstrated that the P(AA-co-AM)layer modulated the tensile properties of hydrogel networks,and the bilayer configuration significantly outperformed the pristine PNIPAM hydrogel.Benefiting from the synergistic effects of kinetic regulation and mechanical modulation,the bilayer hydrogel further exhibited multi-substrate adhesion and reversible deformation,enabling an underwater gripping demonstration.This work highlights a polyoxometalate-enabled strategy for simultaneously controlling thermo-responsive kinetics and toughening PNIPAM-based hydrogels,thereby advancing functional soft materials for actuation-related applications. 展开更多
关键词 bilayer hydrogel phase transition PNIPAM polyoxometalates programmable actuation
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Structural basis of the major TMPRSS2 promoter G-quadruplex and its complex with berberine 认领 引用
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作者 Zhiyu Tang Yuting Bian +8 位作者 Shangran Li Zhiyuan Chen Yingying Wang Yongqiang Zhang Yipu Li Yushuang Liu Minghua Yang Lingyi Kong Kaibo Wang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第2期237-246,共10页
TMPRSS2 plays a crucial role in facilitating the entry of both the influenza virus and the SARSCoV-2 coronavirus into host cells.Recent studies have identified a guanine-rich sequence in the proximal promoter region o... TMPRSS2 plays a crucial role in facilitating the entry of both the influenza virus and the SARSCoV-2 coronavirus into host cells.Recent studies have identified a guanine-rich sequence in the proximal promoter region of the TMPRSS2 gene,which can form G-quadruplex structures(TMPRSS2-G4s)that are potential targets for small molecules to inhibit TMPRSS2 expression.However,the structural details of the major TMPRSS2-G4 and its complex with small molecules remain unknown,hindering the development of antiviral drugs targeting TMPRSS2-Gquadruplexes(G4s).This study reports the first high-resolution nuclear magnetic resonance(NMR)solution structure of the major TMPRSS2-G4,which consists of a three-tetrad core parallel-stranded G4.Both 3′and 5′flanking regions form well-defined capping structures stabilized by multiple hydrogen bonds.Importantly,we found that berberine,an antiviral alkaloid,strongly binds to the major TMPRSS2-G4 and determined its binding complex structure with TMPRSS2-G4 at a 2∶1 binding stoichiometry.Each berberine molecule recruits an adjacent flanking residue,forming a coplanar structure superimposed on two outer G-tetrads.Moreover,we demonstrated that the major TMPRSS2-G4 can stably form within a longer deoxyribonucleic acid(DNA)context and be targeted by small molecules to inhibit DNA polymerase activity.Overall,this study provides structural insights into the recognition mechanism of small molecules by the major TMPRSS2-G4 and may facilitate the development of novel antiviral therapeutics targeting TMPRSS2-G4. 展开更多
关键词 DNA G-quadruplex NMR solution structure TMPRSS2 Berberine Antivirus
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Design,synthesis,and biological evaluation of 2-(benzylsulfonyl)-5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazole derivatives as novel herbicides 认领 引用
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作者 Sheng Yan Chujian Ma +5 位作者 Lamei Wu Changsheng Ma Yingying Wang Dingfeng Luo Zuren Li Zhijun Dai 《Advanced Agrochem》 CAS CSCD 2026年第1期25-32,共8页
To develop herbicides with a novel mechanism of action,a series of 1,3,4-oxadiazolpyridine derivatives were designed and synthesized based on active substructure splicing and structure optimization.These derivatives(5... To develop herbicides with a novel mechanism of action,a series of 1,3,4-oxadiazolpyridine derivatives were designed and synthesized based on active substructure splicing and structure optimization.These derivatives(5aa-5bd)were characterized by their melting points,1H and13C nuclear magnetic resonance spectroscopy,and high-resolution mass spectrometry.The configuration of 5 al was determined using single-crystal X-ray diffraction.Additionally,5 al exhibited excellent herbicidal activity at a dosage of 75 g/hm2,showing an EC 50 of 4.03 g/hm2against both E.crus-galli and quinclorac-resistant E.crus-galli.At a dosage of 375 g/hm 2,5 al was safe for application on rice and sorghum and showed low toxicity(>200μg/g)towards Apis mellifera.After treatment with 5 al,the lamellae of the chloroplast grana of barnyard grass leaves were stacked disorderly and arranged loosely,and some thylakoids were broken,as observed by transmission electron microscopy.Transcriptomics analysis of E.crus-galli revealed that 5 al affects the defense response,membranes,plasma membranes,and chloroplasts of differentially expressed genes,which alter membrane permeability and energy metabolism,potentially leading to plant death.Thus,we successfully developed a novel molecular scaffold with a new mechanism of action that exhibits herbicidal activity against resistant E.crus-galli.Therefore,further development of lead herbicides based on this scaffold is required. 展开更多
关键词 Active substructure splicing Herbicidal activity Resistant barnyardgrass Transcriptomics.structure optimization
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2013年至2022年上海市浦东新区居民大肠癌筛查病例特征分析 认领 引用
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作者 王莹莹 黄华 +4 位作者 拓嘉怡 杨琛 徐望红 郝莉鹏 张莉 《中国肿瘤临床》 CAS CSCD 北大核心 2026年第4期176-182,共7页
目的:基于上海市浦东新区大肠癌(colorectal cancer,CRC)筛查项目,分析初筛阳性且肠镜检出异常病变人群的流行病学特征,为项目推广和策略优化提供参考。方法:以2013年至2022年上海市浦东新区173241例50~74岁初筛阳性者为对象,分析肠镜... 目的:基于上海市浦东新区大肠癌(colorectal cancer,CRC)筛查项目,分析初筛阳性且肠镜检出异常病变人群的流行病学特征,为项目推广和策略优化提供参考。方法:以2013年至2022年上海市浦东新区173241例50~74岁初筛阳性者为对象,分析肠镜依从性和初筛方案效能,描述肠镜检出异常病变者的性别和年龄分布、病变谱、解剖部位及CRC病理分期。结果:肠镜依从性为26.2%,男性、年轻组和低文化程度者略高;仅问卷评估阳性者的依从性(16.5%)远低于问卷评估和2次粪便隐血试验(fecal immunochemical tests,FIT)均阳性者(44.0%)。共检出17229例肠道病变,总检出率37.9%,其中CRC为952例(2.1%)、癌前病变4435例(9.8%)。男性、高龄组检出率更高;问卷评估和2次FIT皆阳性者检出率最高(50.6%),仅问卷评估阳性者达31.6%。癌前病变检出高峰男性为60~64岁,女性为70~74岁。病变好发部位依次为乙状结肠、直肠、横结肠、升结肠和降结肠。筛查检出CRC中,0~Ⅰ期占33.1%,Ⅱ期占33.5%,早期比例显著高于非筛查检出病例。结论:问卷评估与FIT初筛继以全结肠镜的序贯策略已在上海市浦东新区取得了良好效果。急需精准动员低依从人群,提升肠镜依从率,才能够持续降低CRC的发病与死亡。 展开更多
关键词 大肠癌 筛查 肠镜 癌前病变 上海市
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Meta-analysis of 21stcentury studies shows that deforestation induces profound changes in soil characteristics,particularly soil organic carbon accumulation 认领 引用 被引量：2
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作者 Abubakari Said Mgelwa Mbezele Junior Yannick Ngaba +9 位作者 Bin Hu Geshere Abdisa Gurmesa Agnes Godfrey Mwakaje Mateg Pascale Bernadette Nyemeck Feifei Zhu Qingyan Qiu Linlin Song Yingying Wang Yunting Fang Heinz Rennenberg 《Forest Ecosystems》 SCIE CAS CSCD 2025年第1期46-55,共10页
Deforestation is one of the most serious environmental problems facing humankind.It continues to escalate rapidly across many regions of the world,thereby deteriorating the forest soil quality.This has prompted a larg... Deforestation is one of the most serious environmental problems facing humankind.It continues to escalate rapidly across many regions of the world,thereby deteriorating the forest soil quality.This has prompted a large number of field-based studies aimed at understanding the impacts of deforestation on soil properties.However,the lack of comprehensive meta-analyses that utilized these studies has limited our deeper understanding of how different soil properties,including the soil organic carbon(SOC)pool,respond to deforestation.To address this critical knowledge gap,we conducted a meta-analysis of 144 studies to explore the impacts of deforestation on soil chemical,physical,and biological properties,with special emphasis on the long-term changes in SOC,such as concentrations,stocks,and sequestration.The results revealed that deforestation significantly decreased soil organic matter,electrical conductivity,and base saturation by 52%,50%,and 98%,respectively.While deforestation increased soil total nitrogen content and decreased available phosphorus content by 51%and 99%,respectively,it resulted in slight decreases in some chemical properties,including soil pH(1%)and base cations(1%–13%).Deforestation significantly increased bulk density by 27%and soil erosion by 47%,but significantly decreased soil aggregate stability by 39%and saturated hydraulic conductivity by 63%.Soil microbial biomass C and N concentrations and enzyme activities were significantly decreased as a consequence of deforestation.Soil biological properties were much more affected by deforestation than soil physical and chemical properties.Regarding the SOC,the land use conversion from forest to pasture significantly increased SOC concentrations,stocks,and sequestration rates(11%–13%),whereas the land use conversions from forest to both plantation and cropland significantly decreased SOC concentrations,stocks,and sequestration rates(10%–43%).This observed decline in SOC accumulations decreased with increasing years after deforestation.The SOC dynamics following deforestation were predominantly regulated by microbial biomass concentrations,dehydrogenase activity,soil erosion,saturated hydraulic conductivity,aggregate stability,as well as concentrations of total organic carbon,total nitrogen,total phosphorus and organic matter.The present meta-analytical study provides compelling evidence that deforestation can induce profound changes in soil characteristics,including soil C contents,and has significant implications for soil health sustainability and climate change mitigation. 展开更多
关键词 Deforestation Land-use change Soil properties Soil organic carbon
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Development of Gossypium hirsutum–Gossypium raimondii introgression lines and their use in QTL mapping of agricultural traits 认领 引用 被引量：1
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作者 Liang Wang Nijiang Ai +12 位作者 Zechang Zhang Chenhui Zhou Guoli Feng Sheng Cai Ningshan Wang Liuchun Feng Yu Chen Min Xu Yingying Wang Haoran Yue Mengfei Chen Liangshuai Xing Baoliang Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第5期1688-1703,共16页
Gossypium raimondii(2n=2x=26,D5),an untapped wild species,is the putative progenitor of the D-subgenome of G.hirsutum(2n=4x=52,AD1),an extensively cultivated species.Here,we developed a G.hirsutum(recipient)–G.... Gossypium raimondii(2n=2x=26,D5),an untapped wild species,is the putative progenitor of the D-subgenome of G.hirsutum(2n=4x=52,AD1),an extensively cultivated species.Here,we developed a G.hirsutum(recipient)–G.raimondii(donor)introgression population to exploit the favorable QTLs/genes and mapped potential quantitative trait loci(QTLs)from wild cotton species.The introgression population consisted of 256 lines with an introgression rate of 52.33%for the G.raimondii genome.The introgression segment length range was 0.03–19.12 Mb,with an average of 1.22 Mb.The coverage of total introgression fragments from G.raimondii was 386.98 Mb.Further genome-wide association analysis(Q+K+MLM)and QTL mapping(RSTEP-LRT)identified 59 common QTLs,including 14 stable QTLs and six common QTL(co-QTL)clusters,and one hotspot of micronaire(MIC).The common QTLs for seed index all showed positive additive effects,while the common QTLs for boll weight all had negative additive effects,indicating that the linkage between seed index and boll weight could be broken.QTLs for lint percentage showed positive effects and could be beneficial for improving cotton yield.Most QTLs for fiber quality had negative additive effects,implying these QTLs were domesticated/improved in G.hirsutum.A few fiber quality QTLs showed positive additive effects,so they could be used to improve cotton fiber quality.The introgression lines developed could be useful for molecular marker-assisted breeding and mapping QTLs precisely for mining desirable genes from the wild species G.raimondii.Such genes can improve cultivated cotton in the future through a designbreeding approach. 展开更多
关键词 Gossypium hirsutum Gossypium raimondii introgression lines yield fiber quality quantitative trait locus
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Fabrication of Tb/Eu co-doped borosilicate glasses for white-light LED and broadband photodetection 认领 引用 被引量：1
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作者 Hong Jia Yingying Wang +9 位作者 Yi Long Xuying Niu Hui Zhou Jie Yang Yuquan Yuan Yanfei Hu Xiaoyun Xu Xiaofeng Liu Feng Peng Zaijin Fang 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第7期1355-1363,共9页
We successfully prepared a series of rare-earth doped borosilicate glasses using the melt-quenching method,and carefully investigated the luminescent properties and the spectral modulation of Tb/Eucodoped borosilicate... We successfully prepared a series of rare-earth doped borosilicate glasses using the melt-quenching method,and carefully investigated the luminescent properties and the spectral modulation of Tb/Eucodoped borosilicate glasses under UV(200-400 nm)excitation.The results show that the prepared samples have the characteristics of broadband response,excellent transparency and tunable luminescence.By adjusting the excitation wavelength,the emissions of Tb3+,Eu2+and Eu3+ions are observed,which exhibit yellow-green,blue,red color and multi-color even white emissions,respectively.Moreover,the energy transfer between Tb3+and Eu3+ions in the codoped glasses is confirmed.Tb3+absorbs a large number of solar-blind light,transfers to Eu3+and results in intense visible emission in a wide waveband range.This makes the Tb/Eu co-doped glass a desirable candidate for solar-blind light detections.The photodetection system was built and shows a strong and stable response to the UV light of 210-400 nm.Due to broad detection range,high sensitivity and stability,our results offer strong implications for the development of photodetection device for diverse applications. 展开更多
关键词 Rare earth ions Tb/Eu co-doped Borosilicate glass Photodetectors
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H5N1 avian infuenza virus PB2 antagonizes duck IFN-βsignaling pathway by targeting mitochondrial antiviral signaling protein 认领 引用
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作者 Zuxian Chen Bingbing Zhao +7 位作者 Yingying Wang Yuqing Du Siyu Feng Junsheng Zhang Luxiang Zhao Weiqiang Li Yangbao Ding Peirong Jiao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第9期3614-3625,共12页
TypeⅠinterferon(IFN)-mediated innate immune responses represent the first line of host defense against viral infection.However,the molecular mechanisms by which avian infuenza virus(AIV)inhibits typeⅠIFN production ... TypeⅠinterferon(IFN)-mediated innate immune responses represent the first line of host defense against viral infection.However,the molecular mechanisms by which avian infuenza virus(AIV)inhibits typeⅠIFN production in ducks are not well understood.Here,we frst found that the polymerase basic 2(PB2)protein of H5N1 subtype AIV inhibited the typeⅠIFN responses by targeting duck mitochondrial antiviral signaling protein(MAVS).We further demonstrated that H5N1-PB2 bound to theΔtransmembrane(ΔTM)domain of duck MAVS,and the polymerase basic 1(PB1)binding domain(PBD)and RNA binding nuclear import domain(RND)of H5N1-PB2 interacted with MAVS to inhibit typeⅠIFN expression in ducks.Collectively,our fndings contribute to understanding the molecular mechanism by which AIV proteins regulate the retinoic acid-inducible geneⅠ(RIG-Ⅰ)-like receptor(RLR)signaling pathway to evade host antiviral immune responses in ducks. 展开更多
关键词 avian influenza virus polymerase basic 2 mitochondrial antiviral signaling protein duck type I interferon
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Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy 认领 引用
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作者 Songtao Wu Yingying Wang +7 位作者 Denghui Deng Guohua Zheng Hanxiang Mei Cong Wang Xiang Zheng Chun Gui Fei Liao Meixian Xiang 《Natural Products and Bioprospecting》 CSCD 2025年第6期45-63,共19页
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells,and tra-ditional Chinese medicine theory suggests the possibility of combining the two,however,the specific mech... Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells,and tra-ditional Chinese medicine theory suggests the possibility of combining the two,however,the specific mechanisms involved have not been elucidated.This study investigated the therapeutic mechanism of the Realgar-Coptis chin-ensis drug pair(RCCD)against hepatocellular carcinoma(HCC)by identifying its key active compounds and targets.Through integrated LC-MS analysis,transcriptomics,network pharmacology,and bioinformatics,we identified the mechanism of action,key bioactive compounds,and core targets.Molecular docking,molecular dynamics simula-tions,and microscale thermophoresis(MST)validated the binding affinity between key compounds and core targets.TIMER2.0 database was used to analyze the relationship between the core targets and HCC.H22 tumor xenograft mouse model and immunohistochemistry and pathology analyses were performed to validate the antitumor efficacy of the active compounds.RCCD has a high degree of selectivity of lipid metabolism pathway,4-Methylumbellifer-one(4-MU)was the key active compound with strong binding activity to the core target fatty acid synthase(FAS),and 4-MU down-regulated the expression of FASN in tumor tissues and induced apoptosis in HCC cells.In addition,as a hyaluronan synthase(HAS2/3)inhibitor,4-MU interfered with the HA-dependent tumor microenvironment and fibrosis process by inhibiting HAS2/3.Thus,4-MU may inhibit tumor progression by inhibiting FAS and HAS2/3.4-MU extracted from RCCD exerts anti-HCC effects by modulating the activities of FAS and HAS2/3,thereby repro-gramming lipid metabolism and regulating hyaluronan synthesis. 展开更多
关键词 4-MU Liver cancer Cancer Lipid metabolism MST
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Clinical Characteristics and Influencing Factors of Postoperative Pain in Patients Undergoing Gastric Endoscopic Submucosal Dissection 认领 引用
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作者 Fen Deng Liru Pan +8 位作者 Lei Tao Xiaoyu Qiu Bing Li Jing Hao Huihui Li Zhenzhen Zhang Weiwei Ding Yingying Wang Bo Ning 《Health Care Science》 CSCD 2025年第4期289-298,共10页
Background:To comprehensively analyze the clinical characteristics of patients who underwent gastric endoscopic submucosal dissection(ESD)and explore the incidence and influencing factors of postoperative pain.Methods... Background:To comprehensively analyze the clinical characteristics of patients who underwent gastric endoscopic submucosal dissection(ESD)and explore the incidence and influencing factors of postoperative pain.Methods:The clinical data of patients who underwent gastric ESD at our center from 2009 to 2024 were retrospectively analyzed.Pain severity was assessed using a visual analogue scale,with a score≥4 defined as postoperative pain.Based on the presence or absence of postoperative pain,patients were divided into a pain group and a control group.Independent factors influencing postoperative pain were identified using multivariate logistic regression analysis.To control for confounding bias,patients in the case and control groups were matched by sex and lesion size,and the matched participants were further analyzed using a conditional logistic regression model.Results:In total,993 patients were analyzed.The incidence of postoperative pain was 9.1%(95%confidence interval[CI],7.3-11.1).In the univariate analysis,sex,operation duration,anesthesia method,intraoperative electrocoagulation,nasogastric tube placement,and postoperative vomiting were significantly associated with postoperative pain.Multivariate analysis identified eight independent factors:male sex(odds ratio[OR],0.61;95%CI,0.37-0.97;p=0.04),operation duration(OR,1.29;95%CI,1.03-1.63;p=0.02),protuberant lesions(OR,0.43;95%CI,0.26-0.71;p<0.01),antral lesions(OR,1.84;95%CI,1.10-3.05;p=0.01),intubation general anesthesia(OR,0.40;95%CI,0.22-0.72;p=0.002),intraoperative electrocoagulation(OR,0.32;95%CI,0.19-0.55;p<0.01),nasogastric tube placement(OR,2.005;95%CI,1.12-3.57;p=0.01),and postoperative vomiting(OR,3.24;95%CI,1.40-7.47;p=0.005).Conditional logistic regression analysis further identified diabetes mellitus(OR,2.50;95%CI,1.03-6.06;p=0.04).Conclusion:Female sex,diabetes mellitus,concave-type lesions,lesions in the gastric antrum,non-intubation general anesthesia,absence of intraoperative electrocoagulation,prolonged operation duration,nasogastric tube placement,and postoperative vomiting were independent factors associated with moderate to severe pain after gastric ESD.For patients at increased risk of postoperative pain,appropriate prophylactic and therapeutic measures during the perioperative period may effectively alleviate pain following gastric ESD. 展开更多
关键词 clinical characteristics endoscopic submucosal dissection postoperative pain risk factors
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Spatial Differences in Soil Improvement Effect and Panax ginseng Yield:A Case Study of Yanbian Chaoxianzu(Korean)Autonomous Prefecture 认领 引用
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作者 Ziqi XIANG Sihai ZHANG +3 位作者 Lin DAI Qiang YE Yujiao ZHANG Yingying WANG 《Agricultural Biotechnology》 2025年第2期38-43,共6页
[Objectives]Farmland ginseng cultivation,as a sustainable alternative to traditional forest-clearing ginseng planting,requires systematic evaluation of soil optimization strategies.This study aimed to quantify the lin... [Objectives]Farmland ginseng cultivation,as a sustainable alternative to traditional forest-clearing ginseng planting,requires systematic evaluation of soil optimization strategies.This study aimed to quantify the linkage between soil improvement outcomes and ginseng(Panax ginseng)yield across five regions in Yanbian Korean Autonomous Prefecture.[Methods]Soil improvement trials were conducted using farmland soils,with forest soils as the baseline.Soil nutrient contents were measured via soil agrochemical analysis method using a continuous flow analyzer.Statistical approaches,including significance tests,correlation analysis,and regression analysis,were applied to identify key factors influencing yield.[Results]Ginseng yield exhibited a significant positive correlation with organic matter content and available phosphorus,but a negative correlation with electrical conductivity,ammonium nitrogen,and available potassium.Wangqing and Liucai regions achieved post-improvement yields equivalent to 94%and 88%of forest soil yields,respectively,demonstrating the highest soil similarity to forest ecosystems.[Conclusions]Region-specific soil improvement protocols in Wangqing and Liucai show high replicability and efficacy.These strategies can serve as benchmarks for sustainable farmland ginseng cultivation,minimizing ecological disruption while maintaining productivity. 展开更多
关键词 Farmland ginseng cultivation Soil improvement Soil nutrients Yield Correlation analysis
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The SOLIDS 6G Mobile Network Architecture:Driving Forces,Features,and Functional Topology 认领 引用 被引量：31
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作者 Guangyi Liu Na Li +3 位作者 Juan Deng Yingying Wang Junshuai Sun Yuhong Huang 《Engineering》 SCIE EI CAS CSCD 2022年第1期42-59,共18页
With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and ... With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and data technologies(ICDT),and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks.This article surveys the history and driving forces of the evolution of the mobile network architecture and proposes a logical function architecture for sixth generation(6G)mobile network.The proposed 6G network architecture is termed SOLIDS(related to the following basic features:soft,on-demand fulfillment,lite,native intelligence,digital twin,and native security),which can support self-generation,self-healing,self-evolution,and self-immunity without human involvement and address the primary issues in the legacy 5G network(e.g.,high cost,high power consumption,and highly complicated operation and maintenance),significantly well. 展开更多
关键词 Sixth generation Network features Network architecture
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Characterization and mapping of QTLs on chromosome 2D for grain size and yield traits using a mutant line induced by EMS in wheat 认领 引用 被引量：12
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作者 Guizhi Zhang Yingying Wang +3 位作者 Ying Guo Yan Zhao Fanmei Kong Sishen Li 《The Crop Journal》 SCIE CSCD 2015年第2期135-144,共10页
Production of mutants with altered phenotypes is a powerful approach for determining the biological functions of genes in an organism. In this study, a high-grain-weight mutant line M8008 was identified from a library... Production of mutants with altered phenotypes is a powerful approach for determining the biological functions of genes in an organism. In this study, a high-grain-weight mutant line M8008 was identified from a library of mutants of the common wheat cultivar YN15 treated with ethylmethane sulfonate(EMS). F2 and F2:3generations produced from crosses of M8008 × YN15(MY) and M8008 × SJZ54(MS) were used for genetic analysis. There were significant differences between M8008 and YN15 in plant height(PH), spike length(SL),fertile spikelet number per spike(FSS), grain width(GW), grain length(GL), GL/GW ratio(GLW), and thousand-grain weight(TGW). Most simple correlation coefficients were significant for the investigated traits, suggesting that the correlative mutations occurred in M8008. Approximately 21% of simple sequence repeat(SSR) markers showed polymorphisms between M8008 and YN15, indicating that EMS can induce a large number of mutated loci. Twelve quantitative trait loci(QTLs) forming QTL clusters(one in MY and two in MS) were detected. The QTL clusters coinciding with(MY population) or near(MS population) the marker wmc41 were associated mainly with grain-size traits, among which the M8008 locus led to decreases in GW, factor form density(FFD), and TGW and to increases in GLW. The cluster in the wmc25–barc168 interval in the MS population was associated with yield traits, for which the M8008 locus led to decreased PH, spike number per plant(SN), and SL. 展开更多
关键词 Common wheat Mutant Simple sequence repeat(SSR) Quantitative trait locus(QTL) Grain size trait Yield trait
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Weaving 3D highly conductive hierarchically interconnected nanoporous web by threading MOF crystals onto multi walled carbon nanotubes for high performance Li-Se battery 认领 引用 被引量：7
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作者 Chao Li Yingying Wang +7 位作者 Hongyan Li Jing Liu Jianping Song Luca Fusaro Zhi-Yi Hu Yanxin Chen Yu Li Bao-Lian Su 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第8期396-404,I0009,共9页
Lithium-selenium(Li-Se)battery has attracted growing attention.Nevertheless,its practical application is still impeded by the shuttle effect of the formed polyselenides.Herein,we report in-situ hydrothermal weaving th... Lithium-selenium(Li-Se)battery has attracted growing attention.Nevertheless,its practical application is still impeded by the shuttle effect of the formed polyselenides.Herein,we report in-situ hydrothermal weaving the three-dimensional(3 D)highly conductive hierarchically interconnected nanoporous web by threading microporous metal organic framework MIL-68(Al)crystals onto multi-walled carbon nanotubes(MWCNTs).Such 3 D hierarchically nanoporous web(3 D MIL-68(Al)@MWCNTs web)with a very high surface area,a large amount of micropores,electrical conductivity and elasticity strongly traps the soluble polyselenides during the electrochemical reaction and significantly facilitates lithium ion diffusion and electron transportation.Molecular dynamic calculation confirmed the strong affinity of MIL-68(Al)for the adsorption of polyselenides,quite suitable for Li-Se battery.Their hexahedral channels(1.56 nm)are more efficient for the confinement of polyselenides and for the diffusion of electrolytes compared to their smaller triangular channels(0.63 nm).All these excellent characteristics of 3 D MIL-68(Al)@MWCNTs web with suitable confinement of a large amount of selenium and the conductive linkage between MIL-68(Al)host by MWCNTs result in a high capacity of 453 m Ah/g at 0.2 C with 99.5%coulombic efficiency after 200 cycles with significantly improved cycle stability and rate performance.The 3 D MIL-68(Al)@MWCNTs web presents a good performance in Li-Se battery in term of the specific capacity and cycling stability and also in terms of rate performance compared with all the metal-organic framework(MOF)based or MOF derived porous carbons used in Li-Se battery. 展开更多
关键词 Lithium selenium battery Selenium confinement 3D hierarchically nanoporous web Metal-organic framework(MOF) Multi walled carbon nanotubes
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Broadband all-fiber optical phase modulator based on photo-thermal effect in a gas-filled hollow-core fiber 认领 引用 被引量：10
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作者 Shoulin Jiang Feifan Chen +4 位作者 Yan Zhao Shoufei Gao Yingying Wang Hoi Lut Ho Wei Jin 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2023年第5期10-16,共7页
We report broadband all-fiber optical phase modulation based on the photo-thermal effect in a gas-filled hollow-core fiber.The phase modulation dynamics are studied by multi-physics simulation.A phase modulator is fab... We report broadband all-fiber optical phase modulation based on the photo-thermal effect in a gas-filled hollow-core fiber.The phase modulation dynamics are studied by multi-physics simulation.A phase modulator is fabricated using a 5.6-cm-long anti-resonant hollow-core fiber with pure acetylene filling.It has a half-wave optical power of 289 mW at 100 kHz and an average insertion loss 0.6 dB over a broad wavelength range from 1450 to 1650 nm.The rise and fall time constants are 3.5 and 3.7μs,respectively,2–3 orders of magnitude better than the previously reported microfiber-based photo-thermal phase modulators.The gas-filled hollow-core waveguide configuration is promising for optical phase modulation from ultraviolet to mid-infrared which is challenging to achieve with solid optical fibers. 展开更多
关键词 optical modulators photo-thermal effects hollow-core fibers
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