Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of d...Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of death worldwide.In its 2025 report,the World Health Organization(WHO)estimated 10.7 million new TB cases globally,with 1.23 million deaths.Early detection and treatment of TB are crucial for TB control.Community-based active case finding(ACF)is an active case detection strategy that is incorporated as a core component of Pillar 1 of the End TB Strategy and has demonstrated effectiveness in high-burden settings.展开更多
The prediction of sea surface partial pressure of carbon dioxide(pCO2)in the South China Sea is crucial for understanding the region’s contribution to the global carbon budget and its interactions with climate cha...The prediction of sea surface partial pressure of carbon dioxide(pCO2)in the South China Sea is crucial for understanding the region’s contribution to the global carbon budget and its interactions with climate change.We applied the Spatiotemporal Convolutional Long Short-Term Memory(STConvLSTM)model,integrating key environmental factors including sea surface temperature(SST),sea surface salinity(SSS),and chlorophyll a(Chl a),to predict and analyze sea surface pCO2in the South China Sea.The model demonstrated high accuracy in short-term predictions(1 month),with a mean absolute error(MAE)of 0.394,a root mean square error(RMSE)of 0.659,and a coefficient of determination(R2)of 0.998.For long-term predictions(12 months),the model maintained its predictive capability,with an MAE of 0.667,RMSE of 1.255,and R2of 0.994.Feature importance analysis revealed that sea surface pCO2and SST were the main drivers of the model’s predictions,whereas Chl a and SSS had relatively minor impacts.The model’s generalization ability was further validated in the northwest Pacific Ocean and tropical Pacific Ocean,where it successfully captured the spatiotemporal variation in pCO2with small prediction errors.The ST-ConvLSTM model provides an efficient and accurate tool for forecasting and analyzing sea surface pCO2in the South China Sea,offering new insights into global carbon cycling and climate change.This study demonstrates the potential of deep learning in marine science and provides a significant technical support for global changes and marine ecosystem research.展开更多
With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper pro...With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application.展开更多
Helium(He)is considered an indispensable rare resource due to its critical applications in high-tech fields such as low-temperature superconductivity,magnetic resonance imaging,and aerospace.However,the sources of hel...Helium(He)is considered an indispensable rare resource due to its critical applications in high-tech fields such as low-temperature superconductivity,magnetic resonance imaging,and aerospace.However,the sources of helium and its accumulation processes in hydrocarbon basins remain unclear.The Hetianhe gas field,as China's first supergiant He-rich gas field,provides a natural laboratory for studying the mechanisms of helium enrichment.By analyzing the primary gas components and noble gas data from natural gas wells in the Hetianhe gas field,and comparing these with geological data from known He-rich gas fields worldwide,a detailed anatomy of the Hetianhe helium-rich gas field is conducted from three aspects:generation,migration,and accumulation.The Hetianhe gas field is not only uniformly rich in helium but also shows promising exploration potential.Helium tends to accumulate in structural highs within the field.Quantifying the helium isotope ratios(R/Ra)reveals that the helium in the Hetianhe gas field is of typical crustal origin.From a"source-reservoir dual control"perspective,it is calculated that 62%of the helium is sourced from the basement helium source rocks,while 38%comes from sedimentary helium source rocks.The study indicates that the Paleoproterozoic granite basement provides a sufficient helium source,with the fault systems serving as effective migration pathways for helium.The concentration of4He and20Ne in natural gas is positively correlated,which reflects the close relationship between He migration and groundwater.In addition,N2and He in natural gas in the Tarim Basin show a good positive correlation,which further indicates that4He dissolves into the groundwater system before degassing into a gas reservoir and that the variations in the4He concentration in the gas phase are caused by the difference of natural gas lateral migration and charging intensity.Notably,a comparison with the reservoir characteristics of globally recognized He-rich fields reveals that"shallow depth,low pressure,and high structural uplift"are key geological factors for helium accumulation.展开更多
Enhancing the photodetection capabilities of organic photodetectors(OPDs)is crucial for advancing applications in medical monitoring,optical communications,image sensing,and robotics,where a strong,focused peak respon...Enhancing the photodetection capabilities of organic photodetectors(OPDs)is crucial for advancing applications in medical monitoring,optical communications,image sensing,and robotics,where a strong,focused peak response at a specific designed wavelength is essential for improving sensitivity,wavelength selectivity,and resolution in imaging systems.By controlled integration of ZnO layers within PBDBT:BTP-4F-based OPDs to form a Fabry-Perot optical cavity,we developed a cost-effective approach to fabricating highly sensitive OPDs by utilizing PBDBT:BTP-4F organic bulk heterojunctions,and extended its detection wavelengths into the nearinfrared(NIR)range.Our design integrates a single silver(Ag)layer that significantly enhances peak detection at a wavelength of 830 nm,resulting in a remarkably narrow full-width at half maximum(FWHM)wavelength of 30 nm and yielding a photoresponse ten times greater than that of non-resonant devices.Furthermore,by varying the thickness of the ZnO layer from 77 nm to 620 nm,we achieve high spectral tunability,allowing fine adjustments of the resonant peak across a spectrum ranging from ultraviolet(UV)and visible to NIR wavelengths.This sensitive photodetector is also well-suited for applications in photoplethysmography(PPG),effectively detecting pulse signals in the NIR spectrum which has significant potential in medical diagnostics.This work advances the integration of cost-effective,wavelength-selective spectroscopic visible-NIR OPDs,paving the way for the next generation of sensitive photodetectors.展开更多
The clinical management of hypertrophic scars(HSs)remains challenging due to their complex etiology and heterogeneous morphology,underscoring the need for multitarget treatment strategies.In this study,we developed a ...The clinical management of hypertrophic scars(HSs)remains challenging due to their complex etiology and heterogeneous morphology,underscoring the need for multitarget treatment strategies.In this study,we developed a nanocomposite system constructed through the metal-phenolic network-mediated self-assembly of molybdenum polyoxometalate({Mo 154})and epigallocatechin gallate(EGCG),followed by chitosan encapsulation,to generate chitosan-encapsulated{Mo 154}/EGCG(CME)nanoparticles.These nanoparticles were integrated into dissolvable microneedles(CME@MN)to enable transdermal administration.Under near-infrared laser irradiation,CME exhibited a three-pronged therapeutic effect:suppression of collagen overproduction and excessive extracellular matrix(ECM)deposition in human keloid fibroblasts,regulation of proliferation and migration in human umbilical vein endothelial cells,and reprogramming of macrophages toward a proinflammatory M1 phenotype.In vivo,CME@MN patches preferentially accumulated within scar tissue,where they normalized ECM organization,improved collagen fiber rearrangement,and attenuated fibroblast activity through photothermal-enhanced mechanisms while maintaining an excellent safety profile.The CME@MN system represents a potentially transformative approach to HS management by offering a unified platform that simultaneously targets the fibrotic,angiogenic,and inflammatory components of scar pathogenesis.展开更多
In order to attain high catalytic activity and long-term stability in the oxygen evolution reaction(OER),it is essential to design catalysts with hollow structures that integrate both the adsorbate evolution mechanism...In order to attain high catalytic activity and long-term stability in the oxygen evolution reaction(OER),it is essential to design catalysts with hollow structures that integrate both the adsorbate evolution mechanism(AEM)and the lattice oxygen mechanism(LOM).Based on the above issues,we developed a novel templating method and,for the first time,synthesized double-shelled hollow nanospheres of ZIF-67.Utilizing the inherent hollow structure and chemical activity of ZIF-67,and through Cu-Mo co-doping,we prepared a CuCo2S4/MoS2 OER catalyst with dual mechanisms.The Jahn-Teller effect of copper activates lattice oxygen,facilitating LOM in OER.The cooperative interaction between copper and molybdenum atoms induces surface reconstruction in the catalyst,accelerates the deprotonation step in LOM,and aids in the formation of*OOH in AEM,thus reducing energy barriers and optimizing the adsorption of reaction intermediates.The addition of molybdenum further boosts catalytic performance by enhancing both mechanisms,owing to the spatial disparity between Cu and Mo atoms.Due to the compatibility of the dual mechanisms,the catalyst demonstrates outstanding electrochemical performance in alkaline media(320 mV at 100 mA cm-2)and maintains a stable catalytic current in a commercial water-splitting device(500 mA cm-2 for 300 h).This study presents an innovative strategy for designing oxygen evolution reaction catalysts that integrate both AEM and LOM mechanisms.Considering the widespread applications of ZIF-67 in electrocatalysis and electrochemical energy storage,CuCo-G@ZIF-67 not only serves as a versatile precursor for the synthesis of various catalysts but also paves the way for the development of novel transition metal catalysts and multi-shell energy storage materials.展开更多
The rational design of heterostructures to simultaneously optimize local environments and electronic configurations in electrocatalysts represents a promising strategy for enhancing hydrogen oxidation(HOR)and evolutio...The rational design of heterostructures to simultaneously optimize local environments and electronic configurations in electrocatalysts represents a promising strategy for enhancing hydrogen oxidation(HOR)and evolution(HER)reactions,crucial for advancing next-generation anion exchange membrane fuel cells and water electrolyzers.Herein,we report a novel Rusp/TiO2-x-CeO2-xxelectrocatalyst with a triple-interface structure,where Ru species are anchored on the surface of both TiO2-xand CeO2-x.This engineered Rusp/TiO2-x-CeO2-xx exhibits exceptional hydrogen energy conversion in the alkaline solution,significantly outperforming Pt/C.Specifically,the HOR mass activity reaches up to 4978 A/gRu,which is 16 times that of Pt/C(310 A/gPt).Meanwhile,the HER overpotential at 10 mA/cm2is only 21 mV,37 mV lower than that of Pt/C.More importantly,the Rusp/TiO2-x-CeO2-xx demonstrates excellent anti-oxidation ability,maintaining activity even at potentials as high as 1.2 V vs.RHE.Through comprehensive characterization combining electrochemical results,density functional theory(DFT)calculations,in situ Raman spectroscopy,and in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS),we elucidate the dual synergistic effects governing the superior performance:(i)the electron-rich Ru centers induced by TiO2-x-CeO2-xx hybridization effectively weaken adsorption energetics of key intermediates(Had,OHad,COad);and(ii)the unique metal-support interaction creates a local acid environment,which promotes the transport of intermediate species.展开更多
Reconfigurable robots have been widely used in the fields of environmental exploration and multi-task applications,benefitting from their high adaptability and multi-functionality.The module size and reconfiguration s...Reconfigurable robots have been widely used in the fields of environmental exploration and multi-task applications,benefitting from their high adaptability and multi-functionality.The module size and reconfiguration strategy are two key factors determining the locomotion characteristics and application scenarios.Traditional reconfigurable robots face challenges in operating in narrow spaces due to the large individual modules that use complex drive and transmission mechanisms;the incompetent reconfiguration strategy limits the diversity of robot configurations and functions.Here we propose a novel highintegration module using built-in-ceramic actuation unit and construct a series of centimeter-scale piezo robots with a new reconfiguration strategy.The actuation unit achieves ultra-high locomotion speed(90.3 body length per second)and high carrying capability(31.6 times self-weight).The highintegration module,including control,communication,and power-supply units,achieves a movement speed of 590 mm per second.Multi-position magnetic connection is designed to achieve the reconfiguration among the modules,and a method is proposed to help select suitable configuration for specific requirements.Such strategy enables the centimeter-scale piezo robot to cope with various flat work scenarios and achieve wireless image capture,exhibiting great potential for different applications.This work provides inspiration for structural design and functional realization in the field of miniature reconfigurable robots.展开更多
Natural evolution has endowed biological surfaces with unique microstructural features,enabling them to achieve complex functions such as grasping,climbing,and self-cleaning through precise regulation of adhesion.Insp...Natural evolution has endowed biological surfaces with unique microstructural features,enabling them to achieve complex functions such as grasping,climbing,and self-cleaning through precise regulation of adhesion.Inspired by this,bioinspired adhesive microstructures have shown tremendous application potential in the rapidly advancing and highly innovative biomedical field.This paper systematically reviews the adhesion systems of biological surfaces like those of geckos and tree frogs,and conducts an in-depth analysis of the adhesion mechanisms underlying various microstructures and their corresponding bioinspired adhesives from the critical perspective of structural characteristics.It reviews different types of interfacial adhesion models,with special emphasis on the suitability of the Cantor-Borodich profile model for accurately describing multiscale hierarchical adhesive structures in diverse and complex biological systems.The paper focuses on elaborating the significant contributions of bioinspired adhesives in biomedical engineering,particularly their practical and impactful applications in wearable medical devices such as stable adhesion in dynamic physiological environments,surgical instruments such as low-damage soft tissue gripping,and drug delivery systems such as enhanced transdermal delivery efficiency.Additionally,it outlines current development prospects and key challenges such as long-term biocompatibility,environmental adaptability,and structure-function synergistic optimization,providing new ideas and valuable references for further research and application of bioinspired adhesive microstructures in biomedical engineering.展开更多
Measurements from geomagnetic satellites continue to underpin advances in geomagnetic field models that describe Earth's internally generated magnetic field.Here,we present a new field model,MSCM,that integrates v...Measurements from geomagnetic satellites continue to underpin advances in geomagnetic field models that describe Earth's internally generated magnetic field.Here,we present a new field model,MSCM,that integrates vector and scalar data from the Swarm,China Seismo-Electromagnetic Satellite(CSES),and Macao Science Satellite-1(MSS-1)missions.The model spans from 2014.0 to 2024.5,incorporating the core,lithospheric,and magnetospheric fields,and it shows characteristics similar to other published models based on different data.For the first time,we demonstrate that it is possible to successfully construct a geomagnetic field model that incorporates CSES vector data,albeit one in which the radial and azimuthal CSES vector components are Huber downweighted.We further show that data from the MSS-1 can be integrated within an explicitly smoothed,fully time-dependent model description.Using the MSCM,we identify new behavior of the South Atlantic Anomaly,the broad region of low magnetic field intensity over the southern Atlantic.This prominent feature appears split into a western part and an eastern part,each with its own intensity minimum.Since 2015,the principal western minimum has undergone only modest intensity decreases of 290 nT and westward motion of 20 km per year,whereas the recently formed eastern minimum has shown a 2–3 times greater intensity drop of 730 nT with no apparent east-west motion.展开更多
Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed v...Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed via pharmacological interventions,POI is increasingly being explored through adjunctive therapeutic strategies,with acupuncture gaining recognition as a promising option.Acupuncture has demonstrated encouraging potential in promoting gastrointestinal motility in patients with POI.Moreover,recent research has shed light on the therapeutic mechanisms underlying its efficacy.This article aims to present a comprehensive overview of acupuncture as a treatment for POI,highlighting advancements in clinical research and recent elucidations of its mechanistic underpinnings.It aspires to contribute a pivotal reference point for scholars and enthusiasts keen on garnering a deeper understanding of acupuncture’s role in managing POI.展开更多
The two-dimensional(2D)layered material molybdenum disulfide(MoS2)exhibits a special Mo-S-Mo sandwich structure with a rather large spacing,making it a promising candidate as an anode material for sodium storage ap...The two-dimensional(2D)layered material molybdenum disulfide(MoS2)exhibits a special Mo-S-Mo sandwich structure with a rather large spacing,making it a promising candidate as an anode material for sodium storage applications.Unfortunately,the practical applications are limited by their intrinsically low electrical conductivity,significant volume alteration and severe particle agglomeration.In this study,we designed a new two-step solvothermal strategy to synthesize ultrathin nanosheetassembled MoS2hollow nanospheres strongly located onlignite-based carbon(MoS2/C)without any template.The ultrathin nanosheets assembled into hollow structures mitigated the volume changes of MoS2during the(dis)-charge cycles,facilitated Na+diffusion,and reduced the migration energy barrier within MoS2.Lignite-based C enhances the electrical conductivity of MoS2,prevents its aggregation,and alleviates mechanical stress during repeated(dis)charging.The resultant hollow spherical MoS2/C composite exhibits outstanding cyclability and rate performance when used as an anode in sodium-ion batteries,as it delivers a high specific capacity of 515.8 mAh g-1after 1000 cycles at 1.0 A g-1,with a 94.34%capacity retention rate.Even at a high current density of 20 Ag-1,a capacity of 431 mAh g-1can still be obtained after 2000cycles.In particular,the initial Coulombic efficiency of the MoS2anode is markedly enhanced by the incorporation of lignite-based C.展开更多
Automated behavior monitoring of macaques offers transformative potential for advancing biomedical research and animal welfare.However,reliably identifying individual macaques in group environments remains a significa...Automated behavior monitoring of macaques offers transformative potential for advancing biomedical research and animal welfare.However,reliably identifying individual macaques in group environments remains a significant challenge.This study introduces ACE-YOLOX,a lightweight facial recognition model tailored for captive macaques.ACE-YOLOX incorporates Efficient Channel Attention(ECA),Complete Intersection over Union loss(CIoU),and Adaptive Spatial Feature Fusion(ASFF)into the YOLOX framework,enhancing prediction accuracy while reducing computational complexity.These integrated approaches enable effective multiscale feature extraction.Using a dataset comprising 179400 labeled facial images from 1196 macaques,ACE-YOLOX surpassed the performance of classical object detection models,demonstrating superior accuracy and real-time processing capabilities.An Android application was also developed to deploy ACE-YOLOX on smartphones,enabling on-device,real-time macaque recognition.Our experimental results highlight the potential of ACE-YOLOX as a non-invasive identification tool,offering an important foundation for future studies in macaque facial expression recognition,cognitive psychology,and social behavior.展开更多
Agroecological intercropping practices demonstrate dual benefits in pest suppression and soil quality enhancement through diversified planting strategies.Despite these advantages,the current understanding of microbiom...Agroecological intercropping practices demonstrate dual benefits in pest suppression and soil quality enhancement through diversified planting strategies.Despite these advantages,the current understanding of microbiome dynamics in combined root-legume cultivation remains fragmented,particularly the variations in bacterial populations and structural diversity observed when cassava is introduced into legume-intercropped agricultural models.A field experiment was carried out with four treatments:cassava-peanut(Arachis hypogea),cassava-hyacinth bean(Macrotyloma uniflorum'Yazhou'),cassava-Stylosanthes intercropping,and cassava monoculture to characterize longitudinal variations in edaphic nutrient cycling and microbiota configuration parameters(including population density,species richness,and consortia architecture)across distinct plant microhabitats—specifically root-soil interfaces and underground storage organs.Results showed that different intercropping modes significantly increased the starch content by 1.85%,9.17%,and 22.3%,and zinc content by 38.8%,36.2%,and 58.7%respectively.Intercropping with various legumes improved the content of available phosphorus(AP)in cassava rhizosphere soil by 167.9%,80.8%,and 16.5%,respectively.It also improved the composition of the microbial community in the cassava rhizosphere and enhanced the growth and abundance of fungi,including Gibberella,Acrocalyma,and Basidiomycetes,which increased the availability of phosphorus in the soil.These results indicated that intercropping of legumes could improve cassava quality,rhizosphere microbial diversity,and soil nutrient utilization.展开更多
Decarbonizing offshore oil and gas platforms has become a critical challenge in the energy transition.In this article,we propose the following two models for decarbonizing offshore oil and gas platforms to facilitate ...Decarbonizing offshore oil and gas platforms has become a critical challenge in the energy transition.In this article,we propose the following two models for decarbonizing offshore oil and gas platforms to facilitate highly challenging energy transitions:(1)repurposing decommissioned platforms as offshore wind-hydrogen hubs and(2)integrating offshore wind power and hydrogen production systems into operational platforms.This study is conducted to systematically assess the feasibility of the proposed models and further examine their technological challenges,systemic risks,and possible mitigation pathways.The results showed that wind turbines,reverse osmosis desalination,and alkaline water electrolysis have high levels of maturity,whereas subsea hydrogen pipelines and liquid/compressed hydrogen carriers remain comparatively immature.Both models can significantly lower costs,strengthen energy resilience,and reduce emissions.However,large-scale deployment is generally constrained by high capital costs,integration complexity,and fragmented regulatory frameworks.The findings highlight that reusing offshore infrastructure to integrate offshore wind power and hydrogen production systems offers cost and environmental advantages over conventional decommissioning,while integrated supply systems can ensure long-term stability through multi-energy complementarity.The study provides strategic insights for advancing low-carbon transformation and guiding the sustainable and resilient development of offshore energy systems.展开更多
基金supported by the People's Government of Quzhou,which provided special funds for private practical affairs(2021),the Capital Medical University Discipline Construction Funding(0300-123001)the Beijing Municipal Education Commission's New Teacher Aid Project(XJJS202516).
摘要Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)that severely endangers human health.Despite significant progress in global TB control,TB remains one of the top ten causes of death worldwide.In its 2025 report,the World Health Organization(WHO)estimated 10.7 million new TB cases globally,with 1.23 million deaths.Early detection and treatment of TB are crucial for TB control.Community-based active case finding(ACF)is an active case detection strategy that is incorporated as a core component of Pillar 1 of the End TB Strategy and has demonstrated effectiveness in high-burden settings.
基金Supported by the National Key Research and Development Program of China(No.2023YFC3008202)the National Natural Science Foundation of China(No.42406019)the Scientific Research Fund of Zhejiang Provincial Education Department(No.Y202353066)。
摘要The prediction of sea surface partial pressure of carbon dioxide(pCO2)in the South China Sea is crucial for understanding the region’s contribution to the global carbon budget and its interactions with climate change.We applied the Spatiotemporal Convolutional Long Short-Term Memory(STConvLSTM)model,integrating key environmental factors including sea surface temperature(SST),sea surface salinity(SSS),and chlorophyll a(Chl a),to predict and analyze sea surface pCO2in the South China Sea.The model demonstrated high accuracy in short-term predictions(1 month),with a mean absolute error(MAE)of 0.394,a root mean square error(RMSE)of 0.659,and a coefficient of determination(R2)of 0.998.For long-term predictions(12 months),the model maintained its predictive capability,with an MAE of 0.667,RMSE of 1.255,and R2of 0.994.Feature importance analysis revealed that sea surface pCO2and SST were the main drivers of the model’s predictions,whereas Chl a and SSS had relatively minor impacts.The model’s generalization ability was further validated in the northwest Pacific Ocean and tropical Pacific Ocean,where it successfully captured the spatiotemporal variation in pCO2with small prediction errors.The ST-ConvLSTM model provides an efficient and accurate tool for forecasting and analyzing sea surface pCO2in the South China Sea,offering new insights into global carbon cycling and climate change.This study demonstrates the potential of deep learning in marine science and provides a significant technical support for global changes and marine ecosystem research.
摘要With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application.
基金funded by the National Helium Project(42141021)the Petrochemical Joint Fund(U20B6001)the School-Enterprise Cooperation Project(041022070087)。
摘要Helium(He)is considered an indispensable rare resource due to its critical applications in high-tech fields such as low-temperature superconductivity,magnetic resonance imaging,and aerospace.However,the sources of helium and its accumulation processes in hydrocarbon basins remain unclear.The Hetianhe gas field,as China's first supergiant He-rich gas field,provides a natural laboratory for studying the mechanisms of helium enrichment.By analyzing the primary gas components and noble gas data from natural gas wells in the Hetianhe gas field,and comparing these with geological data from known He-rich gas fields worldwide,a detailed anatomy of the Hetianhe helium-rich gas field is conducted from three aspects:generation,migration,and accumulation.The Hetianhe gas field is not only uniformly rich in helium but also shows promising exploration potential.Helium tends to accumulate in structural highs within the field.Quantifying the helium isotope ratios(R/Ra)reveals that the helium in the Hetianhe gas field is of typical crustal origin.From a"source-reservoir dual control"perspective,it is calculated that 62%of the helium is sourced from the basement helium source rocks,while 38%comes from sedimentary helium source rocks.The study indicates that the Paleoproterozoic granite basement provides a sufficient helium source,with the fault systems serving as effective migration pathways for helium.The concentration of4He and20Ne in natural gas is positively correlated,which reflects the close relationship between He migration and groundwater.In addition,N2and He in natural gas in the Tarim Basin show a good positive correlation,which further indicates that4He dissolves into the groundwater system before degassing into a gas reservoir and that the variations in the4He concentration in the gas phase are caused by the difference of natural gas lateral migration and charging intensity.Notably,a comparison with the reservoir characteristics of globally recognized He-rich fields reveals that"shallow depth,low pressure,and high structural uplift"are key geological factors for helium accumulation.
基金the support of the National Natural Science Foundation of China(No.52027817)Shenzhen Science and Technology Innovation Committee(Nos.GJHZ20210705143204013 and JCYJ20200109144614514)State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(No.KFZD202301).
摘要Enhancing the photodetection capabilities of organic photodetectors(OPDs)is crucial for advancing applications in medical monitoring,optical communications,image sensing,and robotics,where a strong,focused peak response at a specific designed wavelength is essential for improving sensitivity,wavelength selectivity,and resolution in imaging systems.By controlled integration of ZnO layers within PBDBT:BTP-4F-based OPDs to form a Fabry-Perot optical cavity,we developed a cost-effective approach to fabricating highly sensitive OPDs by utilizing PBDBT:BTP-4F organic bulk heterojunctions,and extended its detection wavelengths into the nearinfrared(NIR)range.Our design integrates a single silver(Ag)layer that significantly enhances peak detection at a wavelength of 830 nm,resulting in a remarkably narrow full-width at half maximum(FWHM)wavelength of 30 nm and yielding a photoresponse ten times greater than that of non-resonant devices.Furthermore,by varying the thickness of the ZnO layer from 77 nm to 620 nm,we achieve high spectral tunability,allowing fine adjustments of the resonant peak across a spectrum ranging from ultraviolet(UV)and visible to NIR wavelengths.This sensitive photodetector is also well-suited for applications in photoplethysmography(PPG),effectively detecting pulse signals in the NIR spectrum which has significant potential in medical diagnostics.This work advances the integration of cost-effective,wavelength-selective spectroscopic visible-NIR OPDs,paving the way for the next generation of sensitive photodetectors.
基金the financial support from the Fujian Provincial Youth Top-Notch Talent Support Program,China.
摘要The clinical management of hypertrophic scars(HSs)remains challenging due to their complex etiology and heterogeneous morphology,underscoring the need for multitarget treatment strategies.In this study,we developed a nanocomposite system constructed through the metal-phenolic network-mediated self-assembly of molybdenum polyoxometalate({Mo 154})and epigallocatechin gallate(EGCG),followed by chitosan encapsulation,to generate chitosan-encapsulated{Mo 154}/EGCG(CME)nanoparticles.These nanoparticles were integrated into dissolvable microneedles(CME@MN)to enable transdermal administration.Under near-infrared laser irradiation,CME exhibited a three-pronged therapeutic effect:suppression of collagen overproduction and excessive extracellular matrix(ECM)deposition in human keloid fibroblasts,regulation of proliferation and migration in human umbilical vein endothelial cells,and reprogramming of macrophages toward a proinflammatory M1 phenotype.In vivo,CME@MN patches preferentially accumulated within scar tissue,where they normalized ECM organization,improved collagen fiber rearrangement,and attenuated fibroblast activity through photothermal-enhanced mechanisms while maintaining an excellent safety profile.The CME@MN system represents a potentially transformative approach to HS management by offering a unified platform that simultaneously targets the fibrotic,angiogenic,and inflammatory components of scar pathogenesis.
摘要In order to attain high catalytic activity and long-term stability in the oxygen evolution reaction(OER),it is essential to design catalysts with hollow structures that integrate both the adsorbate evolution mechanism(AEM)and the lattice oxygen mechanism(LOM).Based on the above issues,we developed a novel templating method and,for the first time,synthesized double-shelled hollow nanospheres of ZIF-67.Utilizing the inherent hollow structure and chemical activity of ZIF-67,and through Cu-Mo co-doping,we prepared a CuCo2S4/MoS2 OER catalyst with dual mechanisms.The Jahn-Teller effect of copper activates lattice oxygen,facilitating LOM in OER.The cooperative interaction between copper and molybdenum atoms induces surface reconstruction in the catalyst,accelerates the deprotonation step in LOM,and aids in the formation of*OOH in AEM,thus reducing energy barriers and optimizing the adsorption of reaction intermediates.The addition of molybdenum further boosts catalytic performance by enhancing both mechanisms,owing to the spatial disparity between Cu and Mo atoms.Due to the compatibility of the dual mechanisms,the catalyst demonstrates outstanding electrochemical performance in alkaline media(320 mV at 100 mA cm-2)and maintains a stable catalytic current in a commercial water-splitting device(500 mA cm-2 for 300 h).This study presents an innovative strategy for designing oxygen evolution reaction catalysts that integrate both AEM and LOM mechanisms.Considering the widespread applications of ZIF-67 in electrocatalysis and electrochemical energy storage,CuCo-G@ZIF-67 not only serves as a versatile precursor for the synthesis of various catalysts but also paves the way for the development of novel transition metal catalysts and multi-shell energy storage materials.
基金Project supported by the Lanzhou Youth Science and Technology Talent Innovation Project(2024-QN-96)the National Natural Science Foundation of China(22262018)+2 种基金the Local Funds for Scientific and Technological Development Guided by Central Government(25YJF002)the Gansu Key Research and Development Program(Industry Field)(23YFGA0056)supported by Hongliu Outstanding Youth Talents Support Project and Young Faculty Interdisciplinary Research Cultivation Program of Lanzhou University of Technology(LUTXKJC-25003).
摘要The rational design of heterostructures to simultaneously optimize local environments and electronic configurations in electrocatalysts represents a promising strategy for enhancing hydrogen oxidation(HOR)and evolution(HER)reactions,crucial for advancing next-generation anion exchange membrane fuel cells and water electrolyzers.Herein,we report a novel Rusp/TiO2-x-CeO2-xxelectrocatalyst with a triple-interface structure,where Ru species are anchored on the surface of both TiO2-xand CeO2-x.This engineered Rusp/TiO2-x-CeO2-xx exhibits exceptional hydrogen energy conversion in the alkaline solution,significantly outperforming Pt/C.Specifically,the HOR mass activity reaches up to 4978 A/gRu,which is 16 times that of Pt/C(310 A/gPt).Meanwhile,the HER overpotential at 10 mA/cm2is only 21 mV,37 mV lower than that of Pt/C.More importantly,the Rusp/TiO2-x-CeO2-xx demonstrates excellent anti-oxidation ability,maintaining activity even at potentials as high as 1.2 V vs.RHE.Through comprehensive characterization combining electrochemical results,density functional theory(DFT)calculations,in situ Raman spectroscopy,and in situ attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS),we elucidate the dual synergistic effects governing the superior performance:(i)the electron-rich Ru centers induced by TiO2-x-CeO2-xx hybridization effectively weaken adsorption energetics of key intermediates(Had,OHad,COad);and(ii)the unique metal-support interaction creates a local acid environment,which promotes the transport of intermediate species.
基金supported by the National Natural Science Foundation of China(52225501,U23A20617,and 523B2040)the Postdoctoral Science Special Foundation of Heilongjiang Province,China(LBH-TZ2410)the Postdoctoral Fellowship Program of CPSF(GZB20240959)。
摘要Reconfigurable robots have been widely used in the fields of environmental exploration and multi-task applications,benefitting from their high adaptability and multi-functionality.The module size and reconfiguration strategy are two key factors determining the locomotion characteristics and application scenarios.Traditional reconfigurable robots face challenges in operating in narrow spaces due to the large individual modules that use complex drive and transmission mechanisms;the incompetent reconfiguration strategy limits the diversity of robot configurations and functions.Here we propose a novel highintegration module using built-in-ceramic actuation unit and construct a series of centimeter-scale piezo robots with a new reconfiguration strategy.The actuation unit achieves ultra-high locomotion speed(90.3 body length per second)and high carrying capability(31.6 times self-weight).The highintegration module,including control,communication,and power-supply units,achieves a movement speed of 590 mm per second.Multi-position magnetic connection is designed to achieve the reconfiguration among the modules,and a method is proposed to help select suitable configuration for specific requirements.Such strategy enables the centimeter-scale piezo robot to cope with various flat work scenarios and achieve wireless image capture,exhibiting great potential for different applications.This work provides inspiration for structural design and functional realization in the field of miniature reconfigurable robots.
基金supported and funded by the National Natural Science Foundation of China(HWG2022001,12402135,52575201 and 12502114)the China Postdoctoral Science Foundation(2024M763860)support from Chongqing City Science and Technology Program(Grant No.CSTB2025NSCQ-GPX0760,CSTB2025NSCQ-GPX0778 and CSTB2025NSCQ-GPX0784).
摘要Natural evolution has endowed biological surfaces with unique microstructural features,enabling them to achieve complex functions such as grasping,climbing,and self-cleaning through precise regulation of adhesion.Inspired by this,bioinspired adhesive microstructures have shown tremendous application potential in the rapidly advancing and highly innovative biomedical field.This paper systematically reviews the adhesion systems of biological surfaces like those of geckos and tree frogs,and conducts an in-depth analysis of the adhesion mechanisms underlying various microstructures and their corresponding bioinspired adhesives from the critical perspective of structural characteristics.It reviews different types of interfacial adhesion models,with special emphasis on the suitability of the Cantor-Borodich profile model for accurately describing multiscale hierarchical adhesive structures in diverse and complex biological systems.The paper focuses on elaborating the significant contributions of bioinspired adhesives in biomedical engineering,particularly their practical and impactful applications in wearable medical devices such as stable adhesion in dynamic physiological environments,surgical instruments such as low-damage soft tissue gripping,and drug delivery systems such as enhanced transdermal delivery efficiency.Additionally,it outlines current development prospects and key challenges such as long-term biocompatibility,environmental adaptability,and structure-function synergistic optimization,providing new ideas and valuable references for further research and application of bioinspired adhesive microstructures in biomedical engineering.
基金supported by the National Natural Science Foundation of China(Grant No.42274003)PWL was supported by Swarm DISC(Swarm Data,Innovation,and Science Cluster)+2 种基金funded by the European Space Agency(ESAContract No.4000109587)HFR acknowledges funding from the UK Natural Environment Research Council(Grant No.NE/V010867/1)。
摘要Measurements from geomagnetic satellites continue to underpin advances in geomagnetic field models that describe Earth's internally generated magnetic field.Here,we present a new field model,MSCM,that integrates vector and scalar data from the Swarm,China Seismo-Electromagnetic Satellite(CSES),and Macao Science Satellite-1(MSS-1)missions.The model spans from 2014.0 to 2024.5,incorporating the core,lithospheric,and magnetospheric fields,and it shows characteristics similar to other published models based on different data.For the first time,we demonstrate that it is possible to successfully construct a geomagnetic field model that incorporates CSES vector data,albeit one in which the radial and azimuthal CSES vector components are Huber downweighted.We further show that data from the MSS-1 can be integrated within an explicitly smoothed,fully time-dependent model description.Using the MSCM,we identify new behavior of the South Atlantic Anomaly,the broad region of low magnetic field intensity over the southern Atlantic.This prominent feature appears split into a western part and an eastern part,each with its own intensity minimum.Since 2015,the principal western minimum has undergone only modest intensity decreases of 290 nT and westward motion of 20 km per year,whereas the recently formed eastern minimum has shown a 2–3 times greater intensity drop of 730 nT with no apparent east-west motion.
基金Supported by Clinical Key Project of Peking University Third Hospital,No.BYSY2023049Funding from State Key Laboratory of Female Fertility Promotion,Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,No.BYSYSZKF2023027.
摘要Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed via pharmacological interventions,POI is increasingly being explored through adjunctive therapeutic strategies,with acupuncture gaining recognition as a promising option.Acupuncture has demonstrated encouraging potential in promoting gastrointestinal motility in patients with POI.Moreover,recent research has shed light on the therapeutic mechanisms underlying its efficacy.This article aims to present a comprehensive overview of acupuncture as a treatment for POI,highlighting advancements in clinical research and recent elucidations of its mechanistic underpinnings.It aspires to contribute a pivotal reference point for scholars and enthusiasts keen on garnering a deeper understanding of acupuncture’s role in managing POI.
基金financially supported by the National Natural Science Foundation of China(Nos.51962027 and 21968022)the Major Science and Technology Project of Inner Mongolia Autonomous Region(No.2021ZD0016)+5 种基金the National Key R&D Program of China(No.2020YFC1909105)the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(No.NJYT24002)the Central Guidance Fund for Local Scientific and Technological Development(No.2024ZY0012)the Key Project of Tianjin Natural Science Foundation(No.23JCZDJC00570)the Special Funding of China Postdoctoral Science Foundation(No.2023T160268)the China Postdoctoral Science Foundation(No.2023M741362)
摘要The two-dimensional(2D)layered material molybdenum disulfide(MoS2)exhibits a special Mo-S-Mo sandwich structure with a rather large spacing,making it a promising candidate as an anode material for sodium storage applications.Unfortunately,the practical applications are limited by their intrinsically low electrical conductivity,significant volume alteration and severe particle agglomeration.In this study,we designed a new two-step solvothermal strategy to synthesize ultrathin nanosheetassembled MoS2hollow nanospheres strongly located onlignite-based carbon(MoS2/C)without any template.The ultrathin nanosheets assembled into hollow structures mitigated the volume changes of MoS2during the(dis)-charge cycles,facilitated Na+diffusion,and reduced the migration energy barrier within MoS2.Lignite-based C enhances the electrical conductivity of MoS2,prevents its aggregation,and alleviates mechanical stress during repeated(dis)charging.The resultant hollow spherical MoS2/C composite exhibits outstanding cyclability and rate performance when used as an anode in sodium-ion batteries,as it delivers a high specific capacity of 515.8 mAh g-1after 1000 cycles at 1.0 A g-1,with a 94.34%capacity retention rate.Even at a high current density of 20 Ag-1,a capacity of 431 mAh g-1can still be obtained after 2000cycles.In particular,the initial Coulombic efficiency of the MoS2anode is markedly enhanced by the incorporation of lignite-based C.
基金supported by the grants from Yunnan Province(202305AH340006,202305AH340007)CAS Light of West China Program(xbzg-zdsys-202213)。
摘要Automated behavior monitoring of macaques offers transformative potential for advancing biomedical research and animal welfare.However,reliably identifying individual macaques in group environments remains a significant challenge.This study introduces ACE-YOLOX,a lightweight facial recognition model tailored for captive macaques.ACE-YOLOX incorporates Efficient Channel Attention(ECA),Complete Intersection over Union loss(CIoU),and Adaptive Spatial Feature Fusion(ASFF)into the YOLOX framework,enhancing prediction accuracy while reducing computational complexity.These integrated approaches enable effective multiscale feature extraction.Using a dataset comprising 179400 labeled facial images from 1196 macaques,ACE-YOLOX surpassed the performance of classical object detection models,demonstrating superior accuracy and real-time processing capabilities.An Android application was also developed to deploy ACE-YOLOX on smartphones,enabling on-device,real-time macaque recognition.Our experimental results highlight the potential of ACE-YOLOX as a non-invasive identification tool,offering an important foundation for future studies in macaque facial expression recognition,cognitive psychology,and social behavior.
基金supported by the China Agriculture Research System(Grant No.CARS-11-hncyh)the Natural Science Foundation of China(Grant No.32260468)the International Science&Technology Cooperation Program of Hainan Province(Grant No.GHYF2024008).
摘要Agroecological intercropping practices demonstrate dual benefits in pest suppression and soil quality enhancement through diversified planting strategies.Despite these advantages,the current understanding of microbiome dynamics in combined root-legume cultivation remains fragmented,particularly the variations in bacterial populations and structural diversity observed when cassava is introduced into legume-intercropped agricultural models.A field experiment was carried out with four treatments:cassava-peanut(Arachis hypogea),cassava-hyacinth bean(Macrotyloma uniflorum'Yazhou'),cassava-Stylosanthes intercropping,and cassava monoculture to characterize longitudinal variations in edaphic nutrient cycling and microbiota configuration parameters(including population density,species richness,and consortia architecture)across distinct plant microhabitats—specifically root-soil interfaces and underground storage organs.Results showed that different intercropping modes significantly increased the starch content by 1.85%,9.17%,and 22.3%,and zinc content by 38.8%,36.2%,and 58.7%respectively.Intercropping with various legumes improved the content of available phosphorus(AP)in cassava rhizosphere soil by 167.9%,80.8%,and 16.5%,respectively.It also improved the composition of the microbial community in the cassava rhizosphere and enhanced the growth and abundance of fungi,including Gibberella,Acrocalyma,and Basidiomycetes,which increased the availability of phosphorus in the soil.These results indicated that intercropping of legumes could improve cassava quality,rhizosphere microbial diversity,and soil nutrient utilization.
基金supported by the Chinese Academy of Engineering,China(Grant No.2024-HZ-31-03).-。
摘要Decarbonizing offshore oil and gas platforms has become a critical challenge in the energy transition.In this article,we propose the following two models for decarbonizing offshore oil and gas platforms to facilitate highly challenging energy transitions:(1)repurposing decommissioned platforms as offshore wind-hydrogen hubs and(2)integrating offshore wind power and hydrogen production systems into operational platforms.This study is conducted to systematically assess the feasibility of the proposed models and further examine their technological challenges,systemic risks,and possible mitigation pathways.The results showed that wind turbines,reverse osmosis desalination,and alkaline water electrolysis have high levels of maturity,whereas subsea hydrogen pipelines and liquid/compressed hydrogen carriers remain comparatively immature.Both models can significantly lower costs,strengthen energy resilience,and reduce emissions.However,large-scale deployment is generally constrained by high capital costs,integration complexity,and fragmented regulatory frameworks.The findings highlight that reusing offshore infrastructure to integrate offshore wind power and hydrogen production systems offers cost and environmental advantages over conventional decommissioning,while integrated supply systems can ensure long-term stability through multi-energy complementarity.The study provides strategic insights for advancing low-carbon transformation and guiding the sustainable and resilient development of offshore energy systems.