Lattice structures exhibit exceptional specific strength and energy absorption,making them ideal for aerospace and biomedical applications.While both strut-based(Strut-D)and TPMS-based(triply periodic minimal surface-...Lattice structures exhibit exceptional specific strength and energy absorption,making them ideal for aerospace and biomedical applications.While both strut-based(Strut-D)and TPMS-based(triply periodic minimal surface-D)diamond lattice structures show promising mechanical performance,the fundamental differences in their deformation mechanisms and mechanical behavior remain unclear.In this work,Ti-6Al-4V Strut-D and TPMS-D structures with 20%volume fraction were fabricated via electron beam melting(EB-PBF)and their compressive behavior and microstructure were systematically investigated.Compared to Strut-D,TPMS-D structures demonstrate superior mechanical properties:elastic modulus increased by 18.0%(1.51 GPa vs 1.28 GPa),compressive strength enhanced by 28.9%(58.4 MPa vs 45.3 MPa),and energy absorption at densification improved by 57.8%(16.1 MJ m-3vs 10.2 MJ m-3).Finite element analysis revealed that the continuous curved surfaces of TPMS-D disperse stress more uniformly,avoiding stress concentration at nodes and enabling more material to bear load.In contrast,Strut-D exhibits localized stress at strut-node junctions,leading to premature failure.This study clarifies the topological influence on mechanical responses and provides insights for designing high-performance lattice structures.展开更多
Recovery of palladium from spent catalysts is of great practical significance for the construction of ecological civilization and resource recycling.However,for environmentally friendly adsorption methods,designing sp...Recovery of palladium from spent catalysts is of great practical significance for the construction of ecological civilization and resource recycling.However,for environmentally friendly adsorption methods,designing specialized capture vacancies with high capacity and precise selectivity for Pd(Ⅱ) ions remains a challenge.Herein,a salicylic acid-modified nanofiber(SANF),exhibiting specific spatial configuration and constructing a capture vacancy by "O-O" of hard bases,was designed and employed for recovering and separating palladium.The adsorption results indicated that the SANF exhibited a fast capture rate(reaching adsorption equilibrium within60 min) and a large capture capacity(about 170 mg/g) for Pd(Ⅱ) ions,and the capture process was exothermic and spontaneous.Additionally,the Lewis basicity of the capture vacancy after tuning better matches the Lewis acidity of Pd(Ⅱ) ions,which achieves a high-selectivity separation of Pd(Ⅱ) ions(selectivity coefficient for K(Ⅰ),Na(Ⅰ) Ca(Ⅱ),Mg(Ⅱ) and Al(Ⅲ) ions are 1505.2,10,536.7,1128.9,2634.2 and 2873.6,respectively).Practical applications showed that SANF was enabled to recover Pd(Ⅱ) ions from spent catalyst leachate and achieved four time adsorption-desorption cycles,possessing some industrial promise.Furthermore,the matching mechanism between the Lewis basicity of the capture vacancy and the Lewis acidity of the Pd(Ⅱ) ions was revealed through series characterization and theoretical calculations.Finally,it is proposed a Lewis basicity tuning strategy founded on a specific spatial structure,provides a new insight for the design and construction of a capture vacancy for Pd(Ⅱ) ions in the future.展开更多
In the topology optimization of the multiscale structure,how to ensure the connectivity between adjacent microstructures,how to control the design space of microstructures,and how to reduce the amount of calculation a...In the topology optimization of the multiscale structure,how to ensure the connectivity between adjacent microstructures,how to control the design space of microstructures,and how to reduce the amount of calculation and improve calculation efficiency are three basic challenging issues currently faced.To this end,this paper proposes a data-driven approach to achieve the integrated optimization of macroscopic topology and microscopic configuration of the graded functional cellular structures.At the macro level,a topological description function is introduced to realize the topological control of the macrostructure.At the micro level,several cutting functions are used to realize the control of the configuration and size of the microstructure.The integrated optimization design of macro and micro cellular structures can be realized.Based on the computational homogenization method and numerical integration technology,an optimization problem independent offline microstructure database is established at the microscopic scale,where the relationship between the equivalent elastic parameters,relative pseudo-density,and design variables of the microstructure is stored.Based on this offline database,the entire topology optimization process is completed only on a macro scale,which greatly reduces the amount of calculation and improves calculation efficiency.In addition,implicit geometric modeling of full-scale cellular structures can be achieved using the reconstruction technique introduced in this work,which ensures smooth connection between adjacent microstructures.Finally,numerical examples are used to verify the effectiveness of the algorithm and the superiority of gradient cellular structures compared with single-scale structures.展开更多
Long-term use of Sorafenib(SOR)in patients with hepatocellular carcinoma will lead to drug resistance,leading to diarrhea,weight loss and other adverse reactions.Cistanche deserticola,as a homologous substance of medi...Long-term use of Sorafenib(SOR)in patients with hepatocellular carcinoma will lead to drug resistance,leading to diarrhea,weight loss and other adverse reactions.Cistanche deserticola,as a homologous substance of medicine and food,its total glycosides(TG)have anti-hepatocellular carcinoma activity.This paper aimed to explore the anti-hepatocellular carcinoma effect of TG combined with SOR on mice and its mechanism.In this study,according to the previous research of experts,the dosage of 30 mg/kg SOR was selected,aiming at giving consideration to the anti-tumor effect and reducing toxicity.Specifically,HepG2 cells were used to establish a subcutaneous tumorigenic model.Histological changes,oxidative stress,immune regulation and intestinal metabolism and microbial composition of mice were detected.It was found TG did not affect the normal growth of mice without any toxic side effects and could synergize with SOR to inhibit tumor growth.Hematoxylin-eosin results found mice in TG group had more complete hepatocyte structure and less pathological changes in liver.The tumor tissue cells became rare and necrotic.TUNEL staining results revealed that TG could significantly promote apoptosis of HepG2 cells,but at a lower level than SOR.In addition,the content of catalase(CAT),superoxide dismutase(SOD)and glutamic-pyruvic transaminase(ALT)increased,aspartate aminotransferase(AST)and alkaline phosphatase(ALP)decreased,indicating TG could effectively reduce liver lesions.TG could also decrease the content of interleukin-2(IL-2),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),etc.,and increase interferon-γ(IFN-γ),granulocyte-macrophage colony stimulating factor(GM-CSF).Meanwhile,immunohistochemistry was used to observe the decreased expression of Ki67,β-catenin and dishevelled(Dsh)proteins and the increased GSK-3βin the tumor tissues,it was presumed that TG exerted its anti-hepatocellular carcinoma activity through the Wnt/β-catenin signaling pathway.Most importantly,TG could synergize with SOR to regulate metabolic levels in the gut,balance intestinal microbial composition,and increase the abundance of beneficial intestinal bacteria.In conclusion,the results showed that TG(64 mg/kg)could assist SOR(30 mg/kg)to inhibit the development of hepatocellular carcinoma,provide some theoretical basis and technical support.C.deserticola,as a homologous substance of medicine and food,its combination with SOR can provide a new idea for the treatment of hepatocellular carcinoma and its future application potential is worth further exploration and development.展开更多
Proton ceramic fuel cell efficiently converts chemical energy into electrical energy,representing a pivotal component of future energy systems.However,its current performance is hindered by limitations in cathode and ...Proton ceramic fuel cell efficiently converts chemical energy into electrical energy,representing a pivotal component of future energy systems.However,its current performance is hindered by limitations in cathode and electrolyte materials,thereby impeding commercialization.Anion doping emerges as a promising strategy to enhance the electrochemical efficiency of perovskite-based cathodes and electrolytes.However,integrating this approach within a single-cell structure still requires further research.In this study,F-doped perovskite oxides BaCo0.4Fe0.4Zr0.1Y0.1O2.9-δF0.1(BCFZYF)and BaZr0.1Ce0.7Y0.1Yb0.1O2.9-δF0.1(BZCYYbF)were synthesized for use as the cathode and electrolyte,respectively,in proton ceramic fuel cells.Our findings demonstrate that F-doped perovskite oxides exhibit superior electrochemical performance and enhanced structural stability.Furthermore,doping both electrodes and electrolytes with F ions improves their interfacial compatibility.The cell configuration BCFZYF|BZCYYbF|Ni-BZCYYbF achieved a peak power density of 998 mW·cm−2at 650℃using H2as fuel,and it maintained stable operation for over 400 h at 550℃with a current density of 400 mA·cm−2.This research underscores an effective strategy for enhancing the performance and durability of proton ceramic fuel cells.展开更多
Dear Editor,In recent decades,vector-transmitted emerging and re-emerging diseases pose public health issues around the world,in which emerging tick-borne viruses(TBVs)have played a major role since they are widely di...Dear Editor,In recent decades,vector-transmitted emerging and re-emerging diseases pose public health issues around the world,in which emerging tick-borne viruses(TBVs)have played a major role since they are widely distributed.TBVs have a wide range of hosts,including humans,livestock and rodents,with some of them able to cause severe diseases in human and domestic animals,such as Jingmen tick virus(JMTV)(Qin et al.,2014),tick-borne encephalitis virus(TBEV)(Xing et al.,2017),and Alongshan virus(ALSV)(Wang et al.,2019).Of the merging TBVs,JMTV is a novel pathogen that was first identified in Rhipicephalus microplus collected from the Jingmen city of Hubei province,China in 2010(Qin et al.,2014).展开更多
In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh enviro...In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh environment leads to significant variations in the shape and size of the defects.To address this challenge,we propose the multivariate time series segmentation network(MSSN),which adopts a multiscale convolutional network with multi-stage and depth-separable convolutions for efficient feature extraction through variable-length templates.To tackle the classification difficulty caused by structural signal variance,MSSN employs logarithmic normalization to adjust instance distributions.Furthermore,it integrates classification with smoothing loss functions to accurately identify defect segments amid similar structural and defect signal subsequences.Our algorithm evaluated on both the Mackey-Glass dataset and industrial dataset achieves over 95%localization and demonstrates the capture capability on the synthetic dataset.In a nuclear plant's heat transfer tube dataset,it captures 90%of defect instances with75%middle localization F1 score.展开更多
The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The...The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium(DSS)-induced colitis.The findings suggested that SPP effectively eased ulcerative colitis(UC)symptoms in mice by decreasing disease activity index,ameliorating histopathological injury,and decreasing serum and colonic markers of inflammation.In addition,our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1(ZO-1),claudin-1,claudin-3,occludin,and adherens junction protein E-cadherin1.Further,SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut.These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.展开更多
Correction to:J.Iron Steel Res.Int.http://gffzzd3cc09b8251d45dfs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/10.1007/s42243-025-01460-1 The publication of this article unfortunately contained mistakes.The revised and accepted dates were not correct.The corrected dates are gi...Correction to:J.Iron Steel Res.Int.http://gffzzd3cc09b8251d45dfs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/10.1007/s42243-025-01460-1 The publication of this article unfortunately contained mistakes.The revised and accepted dates were not correct.The corrected dates are given below.展开更多
Objective:Acupuncture can effectively alleviate neuronal damage following traumatic brain injury(TBI);however,the underlying mechanisms remain unclear.This study aimed to investigate the putative mech-anisms of acupun...Objective:Acupuncture can effectively alleviate neuronal damage following traumatic brain injury(TBI);however,the underlying mechanisms remain unclear.This study aimed to investigate the putative mech-anisms of acupuncture by examining the expression of Toll-like receptor 4(TLR4),inhibitor ofκB kinase(IKK)complex,nuclear factorκB(NF-κB)p65,and microglial polarization.Methods:Specific pathogen-free(SPF)male Sprague-Dawley(SD)rats were divided into normal,TBI,and acupuncture groups,with 10 rats per group.Except for the normal group,the rat TBI model was estab-lished using Feeney’s free-fall impact method.The acupuncture group received acupuncture intervention at the acupoints“Yamen(GV15)”,“Fengfu(GV16)”,“Baihui(GV20)”,“Shuigou(GV26)”,and“Hegu(LI4)”,once daily for 15 min per session for 5 days.The normal and TBI groups received no treatment,but were restrained for 15 min.Neurological dysfunction was assessed using the modified Neurological Severity Score(mNSS)on Days 1 and 5.Nissl staining and immunohistochemical staining for microglial M1(CD86)and M2(CD206)markers were used to observe the histopathological changes in the cortical tissue of TBI rats.Western blotting was employed to detect the expression of TLR4,IKKα+IKKβ,p-IKKα/β,p-IκBα,and NF-κB p65.Results:(1)Compared to the normal group,the TBI group showed a significant increase in the mNSS score(P<0.01).Nissl staining revealed disorganized neuronal cells,pyknotic nuclei,and fragmented and significantly decreased Nissl bodies.Immunohistochemistry demonstrated significantly increased ex-pression of both CD86+ and CD206+cells in the injured area(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα/β,and p-IκBα in the cerebral cortex was significantly upregulated(P<0.05 or P<0.01),and NF-κB p65 expression in the nuclear protein fraction was increased(P<0.01).(2)Compared to the TBI group,the acupuncture group exhibited a significant decrease in the mNSS score(P<0.01).Nissl staining revealed improved neuronal structure,reduced number of pyknotic nuclei,and a significant increase in Nissl bodies.Immunohistochemistry indicated significantly decreased CD86+cell expression(P<0.01)and significantly increased CD206+cell expression(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα,and p-IκBα in the cerebral cortex was significantly reduced(P<0.05),and NF-κB p65 expression in the nuclear protein fraction was significantly decreased(P<0.01).Conclusions:Acupuncture downregulates the expression of TLR4 and IKKα+IKKβ,inhibits the phospho-rylation of IKKα/β and IκBα,reduces the nuclear expression of NF-κB p65,suppresses microglial M1 polarization,indirectly promotes M2 polarization,ameliorates neuronal damage after TBI,and promotes neural repair.展开更多
The effect of rare-earth cerium on impurity P-induced embrittlement for an advanced SA508Gr.4N reactor pressure vessels steel is investigated by virtue of microstructural characterization,Auger electron spectroscopy(A...The effect of rare-earth cerium on impurity P-induced embrittlement for an advanced SA508Gr.4N reactor pressure vessels steel is investigated by virtue of microstructural characterization,Auger electron spectroscopy(AES),and spin-polarized density functional theory(DFT)calculations.The ductile-to-brittle transition temperatures(DBTTs)are evaluated by Charpy impact testing,and grain boundary segregation(GBS)of P is quantified by AES.Trace addition of Ce can effectively reduce GBS level of P,thereby substantially decreasing the embrittlement induced by P.A linear correlation between DBTT(℃)and GBS level of P(Cp,at.%)is observed for both undoped and Ce-doped samples,being expressed as DBTT=13.13Cp-335.70(undoped)and DBTT=12.67Cp-350.78(Ce-doped).In the absence of GBS of P,the incorporation of Ce appears to play a pivotal role in augmenting the intrinsic toughness.These results imply that the impact of Ce on impurity P-induced embrittlement may be attributed to a combination of increasing the intrinsic toughness and lowering GBS of P.DFT calculations indicate that there is a negligible interaction between Ce and P in the ternary alloy,and thus GBS of P and Ce is mainly site-competitive.展开更多
基金the Jiangsu Province Graduate Research and Practice Innovation Program(SJCX24-2505)the Innovation Talent Promotion Program-Shaanxi Province Young Science and Technology New Star Project(2025ZC-KJXX-72)+1 种基金the Xi'an Talent Program(XAYC2400)the Innovation Capability Support Program of Shaanxi(2023-CX-TD-54).
摘要Lattice structures exhibit exceptional specific strength and energy absorption,making them ideal for aerospace and biomedical applications.While both strut-based(Strut-D)and TPMS-based(triply periodic minimal surface-D)diamond lattice structures show promising mechanical performance,the fundamental differences in their deformation mechanisms and mechanical behavior remain unclear.In this work,Ti-6Al-4V Strut-D and TPMS-D structures with 20%volume fraction were fabricated via electron beam melting(EB-PBF)and their compressive behavior and microstructure were systematically investigated.Compared to Strut-D,TPMS-D structures demonstrate superior mechanical properties:elastic modulus increased by 18.0%(1.51 GPa vs 1.28 GPa),compressive strength enhanced by 28.9%(58.4 MPa vs 45.3 MPa),and energy absorption at densification improved by 57.8%(16.1 MJ m-3vs 10.2 MJ m-3).Finite element analysis revealed that the continuous curved surfaces of TPMS-D disperse stress more uniformly,avoiding stress concentration at nodes and enabling more material to bear load.In contrast,Strut-D exhibits localized stress at strut-node junctions,leading to premature failure.This study clarifies the topological influence on mechanical responses and provides insights for designing high-performance lattice structures.
基金supported by Sichuan Science and Technology Program(No.2024YFHZ0103)Anhui Province Applied Peak Cultivation Discipline(No.XK-XJGF005)+1 种基金Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center(No.[2022]547-49)the Key research and development projects of Shandong Province(No.2023CXGC010903).
摘要Recovery of palladium from spent catalysts is of great practical significance for the construction of ecological civilization and resource recycling.However,for environmentally friendly adsorption methods,designing specialized capture vacancies with high capacity and precise selectivity for Pd(Ⅱ) ions remains a challenge.Herein,a salicylic acid-modified nanofiber(SANF),exhibiting specific spatial configuration and constructing a capture vacancy by "O-O" of hard bases,was designed and employed for recovering and separating palladium.The adsorption results indicated that the SANF exhibited a fast capture rate(reaching adsorption equilibrium within60 min) and a large capture capacity(about 170 mg/g) for Pd(Ⅱ) ions,and the capture process was exothermic and spontaneous.Additionally,the Lewis basicity of the capture vacancy after tuning better matches the Lewis acidity of Pd(Ⅱ) ions,which achieves a high-selectivity separation of Pd(Ⅱ) ions(selectivity coefficient for K(Ⅰ),Na(Ⅰ) Ca(Ⅱ),Mg(Ⅱ) and Al(Ⅲ) ions are 1505.2,10,536.7,1128.9,2634.2 and 2873.6,respectively).Practical applications showed that SANF was enabled to recover Pd(Ⅱ) ions from spent catalyst leachate and achieved four time adsorption-desorption cycles,possessing some industrial promise.Furthermore,the matching mechanism between the Lewis basicity of the capture vacancy and the Lewis acidity of the Pd(Ⅱ) ions was revealed through series characterization and theoretical calculations.Finally,it is proposed a Lewis basicity tuning strategy founded on a specific spatial structure,provides a new insight for the design and construction of a capture vacancy for Pd(Ⅱ) ions in the future.
基金supported by the National Natural Science Foundation of China(Grant Nos.12372200 and 12072242)。
摘要In the topology optimization of the multiscale structure,how to ensure the connectivity between adjacent microstructures,how to control the design space of microstructures,and how to reduce the amount of calculation and improve calculation efficiency are three basic challenging issues currently faced.To this end,this paper proposes a data-driven approach to achieve the integrated optimization of macroscopic topology and microscopic configuration of the graded functional cellular structures.At the macro level,a topological description function is introduced to realize the topological control of the macrostructure.At the micro level,several cutting functions are used to realize the control of the configuration and size of the microstructure.The integrated optimization design of macro and micro cellular structures can be realized.Based on the computational homogenization method and numerical integration technology,an optimization problem independent offline microstructure database is established at the microscopic scale,where the relationship between the equivalent elastic parameters,relative pseudo-density,and design variables of the microstructure is stored.Based on this offline database,the entire topology optimization process is completed only on a macro scale,which greatly reduces the amount of calculation and improves calculation efficiency.In addition,implicit geometric modeling of full-scale cellular structures can be achieved using the reconstruction technique introduced in this work,which ensures smooth connection between adjacent microstructures.Finally,numerical examples are used to verify the effectiveness of the algorithm and the superiority of gradient cellular structures compared with single-scale structures.
基金supported by the National Key Research and Development Program of China(2023YFF1103800)Key and Major Cultivation Project of Beijing Union University(ZK10202501)Key Technology Research on Identification of Risk Factors and Systematic Evaluation of Edible Safety for Animal-derived Novel Food Resources(2023YFF1103803)。
摘要Long-term use of Sorafenib(SOR)in patients with hepatocellular carcinoma will lead to drug resistance,leading to diarrhea,weight loss and other adverse reactions.Cistanche deserticola,as a homologous substance of medicine and food,its total glycosides(TG)have anti-hepatocellular carcinoma activity.This paper aimed to explore the anti-hepatocellular carcinoma effect of TG combined with SOR on mice and its mechanism.In this study,according to the previous research of experts,the dosage of 30 mg/kg SOR was selected,aiming at giving consideration to the anti-tumor effect and reducing toxicity.Specifically,HepG2 cells were used to establish a subcutaneous tumorigenic model.Histological changes,oxidative stress,immune regulation and intestinal metabolism and microbial composition of mice were detected.It was found TG did not affect the normal growth of mice without any toxic side effects and could synergize with SOR to inhibit tumor growth.Hematoxylin-eosin results found mice in TG group had more complete hepatocyte structure and less pathological changes in liver.The tumor tissue cells became rare and necrotic.TUNEL staining results revealed that TG could significantly promote apoptosis of HepG2 cells,but at a lower level than SOR.In addition,the content of catalase(CAT),superoxide dismutase(SOD)and glutamic-pyruvic transaminase(ALT)increased,aspartate aminotransferase(AST)and alkaline phosphatase(ALP)decreased,indicating TG could effectively reduce liver lesions.TG could also decrease the content of interleukin-2(IL-2),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),etc.,and increase interferon-γ(IFN-γ),granulocyte-macrophage colony stimulating factor(GM-CSF).Meanwhile,immunohistochemistry was used to observe the decreased expression of Ki67,β-catenin and dishevelled(Dsh)proteins and the increased GSK-3βin the tumor tissues,it was presumed that TG exerted its anti-hepatocellular carcinoma activity through the Wnt/β-catenin signaling pathway.Most importantly,TG could synergize with SOR to regulate metabolic levels in the gut,balance intestinal microbial composition,and increase the abundance of beneficial intestinal bacteria.In conclusion,the results showed that TG(64 mg/kg)could assist SOR(30 mg/kg)to inhibit the development of hepatocellular carcinoma,provide some theoretical basis and technical support.C.deserticola,as a homologous substance of medicine and food,its combination with SOR can provide a new idea for the treatment of hepatocellular carcinoma and its future application potential is worth further exploration and development.
基金supported by the National Natural Science Foundation of China(No.22278203)The authors appreciate the support of Zhejiang Zheneng Technology and Environment Group Co.,Ltd’s project(No.TD-KJ-23-005:Methanation of carbon monoxide coupled with in-situ formed hydrogen in a low-temperature SOEC reactor).
摘要Proton ceramic fuel cell efficiently converts chemical energy into electrical energy,representing a pivotal component of future energy systems.However,its current performance is hindered by limitations in cathode and electrolyte materials,thereby impeding commercialization.Anion doping emerges as a promising strategy to enhance the electrochemical efficiency of perovskite-based cathodes and electrolytes.However,integrating this approach within a single-cell structure still requires further research.In this study,F-doped perovskite oxides BaCo0.4Fe0.4Zr0.1Y0.1O2.9-δF0.1(BCFZYF)and BaZr0.1Ce0.7Y0.1Yb0.1O2.9-δF0.1(BZCYYbF)were synthesized for use as the cathode and electrolyte,respectively,in proton ceramic fuel cells.Our findings demonstrate that F-doped perovskite oxides exhibit superior electrochemical performance and enhanced structural stability.Furthermore,doping both electrodes and electrolytes with F ions improves their interfacial compatibility.The cell configuration BCFZYF|BZCYYbF|Ni-BZCYYbF achieved a peak power density of 998 mW·cm−2at 650℃using H2as fuel,and it maintained stable operation for over 400 h at 550℃with a current density of 400 mA·cm−2.This research underscores an effective strategy for enhancing the performance and durability of proton ceramic fuel cells.
基金supported by Wildlife Borne Infectious Diseases Monitoring Project of the State Forestry and Grassland Administration of China(2020076060)the National Key Research and Development Program of China to Changchun Tu(32130104).
摘要Dear Editor,In recent decades,vector-transmitted emerging and re-emerging diseases pose public health issues around the world,in which emerging tick-borne viruses(TBVs)have played a major role since they are widely distributed.TBVs have a wide range of hosts,including humans,livestock and rodents,with some of them able to cause severe diseases in human and domestic animals,such as Jingmen tick virus(JMTV)(Qin et al.,2014),tick-borne encephalitis virus(TBEV)(Xing et al.,2017),and Alongshan virus(ALSV)(Wang et al.,2019).Of the merging TBVs,JMTV is a novel pathogen that was first identified in Rhipicephalus microplus collected from the Jingmen city of Hubei province,China in 2010(Qin et al.,2014).
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(2024ZD0608100)the National Natural Science Foundation of China(62332017,U22A2022)
摘要In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh environment leads to significant variations in the shape and size of the defects.To address this challenge,we propose the multivariate time series segmentation network(MSSN),which adopts a multiscale convolutional network with multi-stage and depth-separable convolutions for efficient feature extraction through variable-length templates.To tackle the classification difficulty caused by structural signal variance,MSSN employs logarithmic normalization to adjust instance distributions.Furthermore,it integrates classification with smoothing loss functions to accurately identify defect segments amid similar structural and defect signal subsequences.Our algorithm evaluated on both the Mackey-Glass dataset and industrial dataset achieves over 95%localization and demonstrates the capture capability on the synthetic dataset.In a nuclear plant's heat transfer tube dataset,it captures 90%of defect instances with75%middle localization F1 score.
基金supported by the National Key Research and Development Program of China(2023YFF1103802)。
摘要The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium(DSS)-induced colitis.The findings suggested that SPP effectively eased ulcerative colitis(UC)symptoms in mice by decreasing disease activity index,ameliorating histopathological injury,and decreasing serum and colonic markers of inflammation.In addition,our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1(ZO-1),claudin-1,claudin-3,occludin,and adherens junction protein E-cadherin1.Further,SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut.These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.
摘要Correction to:J.Iron Steel Res.Int.http://gffzzd3cc09b8251d45dfs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/10.1007/s42243-025-01460-1 The publication of this article unfortunately contained mistakes.The revised and accepted dates were not correct.The corrected dates are given below.
基金Supported by National Natural Science Foundation of China:81704156,82174483Guangdong Basic and Applied Basic Research Foundation:2025A1515010371,2024A1515012169。
摘要Objective:Acupuncture can effectively alleviate neuronal damage following traumatic brain injury(TBI);however,the underlying mechanisms remain unclear.This study aimed to investigate the putative mech-anisms of acupuncture by examining the expression of Toll-like receptor 4(TLR4),inhibitor ofκB kinase(IKK)complex,nuclear factorκB(NF-κB)p65,and microglial polarization.Methods:Specific pathogen-free(SPF)male Sprague-Dawley(SD)rats were divided into normal,TBI,and acupuncture groups,with 10 rats per group.Except for the normal group,the rat TBI model was estab-lished using Feeney’s free-fall impact method.The acupuncture group received acupuncture intervention at the acupoints“Yamen(GV15)”,“Fengfu(GV16)”,“Baihui(GV20)”,“Shuigou(GV26)”,and“Hegu(LI4)”,once daily for 15 min per session for 5 days.The normal and TBI groups received no treatment,but were restrained for 15 min.Neurological dysfunction was assessed using the modified Neurological Severity Score(mNSS)on Days 1 and 5.Nissl staining and immunohistochemical staining for microglial M1(CD86)and M2(CD206)markers were used to observe the histopathological changes in the cortical tissue of TBI rats.Western blotting was employed to detect the expression of TLR4,IKKα+IKKβ,p-IKKα/β,p-IκBα,and NF-κB p65.Results:(1)Compared to the normal group,the TBI group showed a significant increase in the mNSS score(P<0.01).Nissl staining revealed disorganized neuronal cells,pyknotic nuclei,and fragmented and significantly decreased Nissl bodies.Immunohistochemistry demonstrated significantly increased ex-pression of both CD86+ and CD206+cells in the injured area(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα/β,and p-IκBα in the cerebral cortex was significantly upregulated(P<0.05 or P<0.01),and NF-κB p65 expression in the nuclear protein fraction was increased(P<0.01).(2)Compared to the TBI group,the acupuncture group exhibited a significant decrease in the mNSS score(P<0.01).Nissl staining revealed improved neuronal structure,reduced number of pyknotic nuclei,and a significant increase in Nissl bodies.Immunohistochemistry indicated significantly decreased CD86+cell expression(P<0.01)and significantly increased CD206+cell expression(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα,and p-IκBα in the cerebral cortex was significantly reduced(P<0.05),and NF-κB p65 expression in the nuclear protein fraction was significantly decreased(P<0.01).Conclusions:Acupuncture downregulates the expression of TLR4 and IKKα+IKKβ,inhibits the phospho-rylation of IKKα/β and IκBα,reduces the nuclear expression of NF-κB p65,suppresses microglial M1 polarization,indirectly promotes M2 polarization,ameliorates neuronal damage after TBI,and promotes neural repair.
基金supported by the China Postdoctoral Science Foundation(No.2023M740973)the Shenzhen Polytechnic University Research Fund,China(No.6023310017K)the National Natural Science Foundation of China(Nos.52071088 and 51871064).
摘要The effect of rare-earth cerium on impurity P-induced embrittlement for an advanced SA508Gr.4N reactor pressure vessels steel is investigated by virtue of microstructural characterization,Auger electron spectroscopy(AES),and spin-polarized density functional theory(DFT)calculations.The ductile-to-brittle transition temperatures(DBTTs)are evaluated by Charpy impact testing,and grain boundary segregation(GBS)of P is quantified by AES.Trace addition of Ce can effectively reduce GBS level of P,thereby substantially decreasing the embrittlement induced by P.A linear correlation between DBTT(℃)and GBS level of P(Cp,at.%)is observed for both undoped and Ce-doped samples,being expressed as DBTT=13.13Cp-335.70(undoped)and DBTT=12.67Cp-350.78(Ce-doped).In the absence of GBS of P,the incorporation of Ce appears to play a pivotal role in augmenting the intrinsic toughness.These results imply that the impact of Ce on impurity P-induced embrittlement may be attributed to a combination of increasing the intrinsic toughness and lowering GBS of P.DFT calculations indicate that there is a negligible interaction between Ce and P in the ternary alloy,and thus GBS of P and Ce is mainly site-competitive.