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Distinctive mechanical responses of strut-based and triply periodic minimal surface(TPMS)Ti-6Al-4V diamond lattice structures produced by electron beam melting 认领 引用
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作者 Li-Na Zhang Yu Guo +5 位作者 Wu Pan Wen-Ge Xu Cheng-Long Teng Rui-Feng Li Sheng Lu Liang-Yu Chen 《Metals Advances》 SCIE EI CAS CSCD 2026年第3期45-54,共10页
Lattice structures exhibit exceptional specific strength and energy absorption,making them ideal for aerospace and biomedical applications.While both strut-based(Strut-D)and TPMS-based(triply periodic minimal surface-... Lattice structures exhibit exceptional specific strength and energy absorption,making them ideal for aerospace and biomedical applications.While both strut-based(Strut-D)and TPMS-based(triply periodic minimal surface-D)diamond lattice structures show promising mechanical performance,the fundamental differences in their deformation mechanisms and mechanical behavior remain unclear.In this work,Ti-6Al-4V Strut-D and TPMS-D structures with 20%volume fraction were fabricated via electron beam melting(EB-PBF)and their compressive behavior and microstructure were systematically investigated.Compared to Strut-D,TPMS-D structures demonstrate superior mechanical properties:elastic modulus increased by 18.0%(1.51 GPa vs 1.28 GPa),compressive strength enhanced by 28.9%(58.4 MPa vs 45.3 MPa),and energy absorption at densification improved by 57.8%(16.1 MJ m-3vs 10.2 MJ m-3).Finite element analysis revealed that the continuous curved surfaces of TPMS-D disperse stress more uniformly,avoiding stress concentration at nodes and enabling more material to bear load.In contrast,Strut-D exhibits localized stress at strut-node junctions,leading to premature failure.This study clarifies the topological influence on mechanical responses and provides insights for designing high-performance lattice structures. 展开更多
关键词 Lattice structure Ti-6Al-4V Electron beam melting Diamond Compressive behavior
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Effective recovering Pd(Ⅱ) ions via tuning the Lewis basicity of nanofiber capture vacancy 认领 引用
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作者 Nianshou Cheng Mingyue Wang +6 位作者 Lu Wang Lin Zhang Chuanbin Li Yu Guo Bo Xing Haichao Wang Min Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第2期690-699,共10页
Recovery of palladium from spent catalysts is of great practical significance for the construction of ecological civilization and resource recycling.However,for environmentally friendly adsorption methods,designing sp... Recovery of palladium from spent catalysts is of great practical significance for the construction of ecological civilization and resource recycling.However,for environmentally friendly adsorption methods,designing specialized capture vacancies with high capacity and precise selectivity for Pd(Ⅱ) ions remains a challenge.Herein,a salicylic acid-modified nanofiber(SANF),exhibiting specific spatial configuration and constructing a capture vacancy by "O-O" of hard bases,was designed and employed for recovering and separating palladium.The adsorption results indicated that the SANF exhibited a fast capture rate(reaching adsorption equilibrium within60 min) and a large capture capacity(about 170 mg/g) for Pd(Ⅱ) ions,and the capture process was exothermic and spontaneous.Additionally,the Lewis basicity of the capture vacancy after tuning better matches the Lewis acidity of Pd(Ⅱ) ions,which achieves a high-selectivity separation of Pd(Ⅱ) ions(selectivity coefficient for K(Ⅰ),Na(Ⅰ) Ca(Ⅱ),Mg(Ⅱ) and Al(Ⅲ) ions are 1505.2,10,536.7,1128.9,2634.2 and 2873.6,respectively).Practical applications showed that SANF was enabled to recover Pd(Ⅱ) ions from spent catalyst leachate and achieved four time adsorption-desorption cycles,possessing some industrial promise.Furthermore,the matching mechanism between the Lewis basicity of the capture vacancy and the Lewis acidity of the Pd(Ⅱ) ions was revealed through series characterization and theoretical calculations.Finally,it is proposed a Lewis basicity tuning strategy founded on a specific spatial structure,provides a new insight for the design and construction of a capture vacancy for Pd(Ⅱ) ions in the future. 展开更多
关键词 Adsorption Pd(Ⅱ)ions Nanofiber Selectivity
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A data-driven integrated optimization method of macroscopic topology and microscopic configuration for the graded functional cellular structures 认领 引用
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作者 Yu Guo Yijie Lu +2 位作者 Zhengwei Zhang Yanguo Zhou Hui Liu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第2期473-495,共23页
In the topology optimization of the multiscale structure,how to ensure the connectivity between adjacent microstructures,how to control the design space of microstructures,and how to reduce the amount of calculation a... In the topology optimization of the multiscale structure,how to ensure the connectivity between adjacent microstructures,how to control the design space of microstructures,and how to reduce the amount of calculation and improve calculation efficiency are three basic challenging issues currently faced.To this end,this paper proposes a data-driven approach to achieve the integrated optimization of macroscopic topology and microscopic configuration of the graded functional cellular structures.At the macro level,a topological description function is introduced to realize the topological control of the macrostructure.At the micro level,several cutting functions are used to realize the control of the configuration and size of the microstructure.The integrated optimization design of macro and micro cellular structures can be realized.Based on the computational homogenization method and numerical integration technology,an optimization problem independent offline microstructure database is established at the microscopic scale,where the relationship between the equivalent elastic parameters,relative pseudo-density,and design variables of the microstructure is stored.Based on this offline database,the entire topology optimization process is completed only on a macro scale,which greatly reduces the amount of calculation and improves calculation efficiency.In addition,implicit geometric modeling of full-scale cellular structures can be achieved using the reconstruction technique introduced in this work,which ensures smooth connection between adjacent microstructures.Finally,numerical examples are used to verify the effectiveness of the algorithm and the superiority of gradient cellular structures compared with single-scale structures. 展开更多
关键词 Graded cellular structure Integrated optimization Data-driven Computational homogenization M-VCUT Level set method
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Total glycosides of Cistanche deserticola enhance the inhibitory effect of Sorafenib on mice with hepatocellular carcinoma 认领 引用
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作者 Duo Feng Jing Wang +6 位作者 Shaoshi Zhang Shiqi Zhou Mengjie Li Xianchun Wang Yu Guo Jian Zhao Wenjie Yan 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3168-3180,共13页
Long-term use of Sorafenib(SOR)in patients with hepatocellular carcinoma will lead to drug resistance,leading to diarrhea,weight loss and other adverse reactions.Cistanche deserticola,as a homologous substance of medi... Long-term use of Sorafenib(SOR)in patients with hepatocellular carcinoma will lead to drug resistance,leading to diarrhea,weight loss and other adverse reactions.Cistanche deserticola,as a homologous substance of medicine and food,its total glycosides(TG)have anti-hepatocellular carcinoma activity.This paper aimed to explore the anti-hepatocellular carcinoma effect of TG combined with SOR on mice and its mechanism.In this study,according to the previous research of experts,the dosage of 30 mg/kg SOR was selected,aiming at giving consideration to the anti-tumor effect and reducing toxicity.Specifically,HepG2 cells were used to establish a subcutaneous tumorigenic model.Histological changes,oxidative stress,immune regulation and intestinal metabolism and microbial composition of mice were detected.It was found TG did not affect the normal growth of mice without any toxic side effects and could synergize with SOR to inhibit tumor growth.Hematoxylin-eosin results found mice in TG group had more complete hepatocyte structure and less pathological changes in liver.The tumor tissue cells became rare and necrotic.TUNEL staining results revealed that TG could significantly promote apoptosis of HepG2 cells,but at a lower level than SOR.In addition,the content of catalase(CAT),superoxide dismutase(SOD)and glutamic-pyruvic transaminase(ALT)increased,aspartate aminotransferase(AST)and alkaline phosphatase(ALP)decreased,indicating TG could effectively reduce liver lesions.TG could also decrease the content of interleukin-2(IL-2),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),etc.,and increase interferon-γ(IFN-γ),granulocyte-macrophage colony stimulating factor(GM-CSF).Meanwhile,immunohistochemistry was used to observe the decreased expression of Ki67,β-catenin and dishevelled(Dsh)proteins and the increased GSK-3βin the tumor tissues,it was presumed that TG exerted its anti-hepatocellular carcinoma activity through the Wnt/β-catenin signaling pathway.Most importantly,TG could synergize with SOR to regulate metabolic levels in the gut,balance intestinal microbial composition,and increase the abundance of beneficial intestinal bacteria.In conclusion,the results showed that TG(64 mg/kg)could assist SOR(30 mg/kg)to inhibit the development of hepatocellular carcinoma,provide some theoretical basis and technical support.C.deserticola,as a homologous substance of medicine and food,its combination with SOR can provide a new idea for the treatment of hepatocellular carcinoma and its future application potential is worth further exploration and development. 展开更多
关键词 Cistanche deserticola Anti-hepatocellular carcinoma Total glycosides Sorafenib Wnt/β-catenin signaling pathway
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致密气单位完全成本概率模型构建 认领 引用 被引量:1
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作者 余果 李海涛 程晓雯 《天然气技术与经济》 2026年第1期76-86,共11页
为了提升致密气田的经济效益并强化风险管理能力、实现开发成本的精准预测与投资决策的科学优化,以四川盆地致密气10项开发方案为样本气藏,采用雷达图分析了影响致密气单位完全成本主控因素,采用蒙特卡罗方法创新建立了致密气单位完全... 为了提升致密气田的经济效益并强化风险管理能力、实现开发成本的精准预测与投资决策的科学优化,以四川盆地致密气10项开发方案为样本气藏,采用雷达图分析了影响致密气单位完全成本主控因素,采用蒙特卡罗方法创新建立了致密气单位完全成本实现概率模型。研究结果表明:(1)致密气受“资源禀赋差异+技术复杂度高”的组合效应影响,单位完全成本显著高于常规气,为常规气单位完全成本的1.2~1.5倍;(2)现阶段致密气单位完全成本以单位折旧折耗为主,占比49.8%,操作成本中以维护及修理费、采出作业费、井下作业费3项费用为主,合计占比达到60.7%;(3)通过层次分析法筛选出6项关键成本因素,并基于高斯、三角、对数正态及伽马分布构建致密气单位完全成本的蒙特卡罗模拟目标函数,实现了多概率密度函数的综合拟合分析;(4)拟合精度对比结果显示,对数正态分布函数的拟合精度显著优于其他密度函数,其P50拟合结果显示致密气单位完全成本为1.049元/m3,与实际数据高度吻合。结论认为,该项研究成果为致密气田开发效益风险预警和最优决策提供了可靠的依据。 展开更多
关键词 致密气 单位完全成本 蒙特卡罗模拟 折旧折耗 操作成本
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人工智能赋能功能陶瓷研发范式的破局逻辑与重塑路径 认领 引用
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作者 刘润林 景一洋 +4 位作者 俞果 高小天 王建 沈忠慧 沈洋 《硅酸盐学报》 EI CAS CSCD 北大核心 2026年第7期2352-2362,共11页
功能陶瓷具备优异的多功能耦合响应特性,是支撑高端智能技术发展的关键无机材料。然而,其性能设计与优化同时受多目标性能权衡、多尺度结构关联以及多物理场耦合效应的“三多”困境共同制约,使功能陶瓷材料设计空间呈现出高维、强约束... 功能陶瓷具备优异的多功能耦合响应特性,是支撑高端智能技术发展的关键无机材料。然而,其性能设计与优化同时受多目标性能权衡、多尺度结构关联以及多物理场耦合效应的“三多”困境共同制约,使功能陶瓷材料设计空间呈现出高维、强约束与高度非线性的特征,导致传统依赖经验试错与正向迭代的研发模式效率不高、可迁移性不足。近年来,人工智能(AI)通过整合数据驱动方法与物理约束建模,推动材料研发由正向预测逐步向逆向设计与闭环优化转变,为破解功能陶瓷长期存在的“三多”困境提供了新的技术路径。基于此,本综述从数据、模型与场景应用3个核心层面,系统梳理了AI赋能功能陶瓷研发的研究进展与共性挑战,并进一步围绕逆向反演决策模型、跨尺度智能计算方法以及大语言模型驱动的协同研发平台3条主线,总结了AI赋能功能陶瓷研发的破局逻辑与内在方法框架。最后,面向功能陶瓷材料-工艺-器件一体化的智能研发需求,总结了当前的发展趋势与未来应用前景。 展开更多
关键词 功能陶瓷 逆向设计 生成模型 智能计算 大模型
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基于改进双向TCN模型的SDN异常流量检测 认领 引用
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作者 孙璇 李彩霞 +4 位作者 李军 任亚唯 代海英 余果 周昊 《信息安全研究》 CSCD 北大核心 2026年第4期303-310,共8页
软件定义网络(software defined network,SDN)技术的集中控制特性在提升网络管理效率的同时也带来更加严峻的安全威胁,准确地检测出SDN网络中的异常流量对网络安全至关重要.针对SDN网络可能遭受的网络攻击以及现有方法异常流量时序建模... 软件定义网络(software defined network,SDN)技术的集中控制特性在提升网络管理效率的同时也带来更加严峻的安全威胁,准确地检测出SDN网络中的异常流量对网络安全至关重要.针对SDN网络可能遭受的网络攻击以及现有方法异常流量时序建模能力不足等问题,提出一种适用于SDN环境下的异常流量检测方法.该方法以流的五元组(源IP地址,目的IP地址,源端口号,目的端口号,传输层协议)为划分依据,提取数据包长度序列作为核心时序特征,并基于改进的双向时间卷积网络(bidirectional temporal convolutional network,BiTCN),通过改用ELU激活函数并在原有时间卷积网络(temporal convolutional network,TCN)结构中增加一层残差网络,同时融合多头挤压激励机制(multi-head squeeze excitation,MSE)以增强特征建模能力,实现对异常行为的识别.实验结果表明,该方法在公开SDN数据集上取得良好效果,其准确率、精确率等指标优于传统基线模型. 展开更多
关键词 异常流量检测 软件定义网络 数据包长度 深度学习 时间卷积网络
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天然气开发方案完全成本构成与管控研究 认领 引用
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作者 杨济源 田萦 +4 位作者 陈艳茹 方一竹 余果 郭卓函 秦泰 《天然气勘探与开发》 CAS 2026年第3期133-143,共11页
科学的经济评估和成本控制有助于天然气行业的高质量发展。为了准确评估气田经济效益和控制成本,采用自主研发的天然气经济评估模型分析了天然气开发方案全成本的构成以及单位全成本的影响机制,所建模型包含高效的矩阵算法并重点关注完... 科学的经济评估和成本控制有助于天然气行业的高质量发展。为了准确评估气田经济效益和控制成本,采用自主研发的天然气经济评估模型分析了天然气开发方案全成本的构成以及单位全成本的影响机制,所建模型包含高效的矩阵算法并重点关注完全成本、单位完全成本及其影响机制。研究结果表明:(1)完全成本的动态均衡主要受油气操作成本与折旧折耗的双重影响;(2)在敏感性分析中,价格的变化使得单位完全成本有可能存在拐点,即价格下降到一定程度将有可能导致短期贷款增加、财务费用上升,进而迅速推高单位完全成本;(3)天然气产量对单位完全成本存在“分母”与“分子”效应,在前者大于后者的前提下,产量下降到一定程度,单位完全成本将迅速上升;(4)经营成本与建设投资主要通过油气操作成本和折旧折耗直接地影响单位完全成本,故它们之间存在着明显的线性关系。结论认为,该项研究成果能够为气田开发方案优选、风险量化及降本增效路径的精准识别与选择提供决策支持。 展开更多
关键词 气田开发 经济评价 完全成本 单位完全成本 敏感性分析 矩阵算法 结构体 数据可视化
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平-波钢板组合墙承载力计算与设计方法 认领 引用
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作者 栾海涛 贺雄 +4 位作者 段劲松 俞果 侯彦果 闻陈宝 朱博莉 《工业建筑》 CAS 2026年第4期94-101,共8页
提出了一种新颖的平-波钢板剪力墙,研究了其弹性屈曲性能与稳定承载力设计计算方法。平-波钢板剪力墙由平钢板和波形钢板标准单元连接而成,后者在工厂通过自动化生产线加工而成,因而生产效率高。通过大量算例的有限元数值计算,分别研究... 提出了一种新颖的平-波钢板剪力墙,研究了其弹性屈曲性能与稳定承载力设计计算方法。平-波钢板剪力墙由平钢板和波形钢板标准单元连接而成,后者在工厂通过自动化生产线加工而成,因而生产效率高。通过大量算例的有限元数值计算,分别研究了焊接连接型与螺栓连接型平-波钢板剪力墙的受剪弹性屈曲模态、弹性屈曲荷载、破坏模式、失稳机理及弹塑性稳定承载力,其中包含不同参数对屈曲与承载力性能的影响,并提出了受剪稳定承载力设计方法。 展开更多
关键词 钢板剪力墙 剪切弹性屈曲 受剪承载力
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致密气单位完全成本三维量化模型构建 认领 引用
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作者 余果 李海涛 程晓雯 《国际石油经济》 2026年第6期106-113,共8页
为深入认识致密气投资项目单位完全成本主控因素,支撑致密气藏规模效益开发,以四川盆地10个致密气藏为研究对象,采用蒙特卡罗方法创新建立致密气单位完全成本三维量化模型。研究结果表明:1)通过层次分析法构建操作成本、折旧折耗、管理... 为深入认识致密气投资项目单位完全成本主控因素,支撑致密气藏规模效益开发,以四川盆地10个致密气藏为研究对象,采用蒙特卡罗方法创新建立致密气单位完全成本三维量化模型。研究结果表明:1)通过层次分析法构建操作成本、折旧折耗、管理费用、财务费用、营业费用、营业税金及附加6项成本费用指标判断矩阵,确定操作成本(权重0.45)与折旧折耗(权重0.23)为致密气开发成本的核心影响因素,一致性检验(一致性比率0.06)验证了权重分配的合理性;2)敏感性分析进一步揭示操作成本与折旧折耗为核心敏感因素;3)构建单位完全成本蒙特卡罗模拟目标函数,创建了操作成本和折旧折耗双因素约束条件下的不同概率区间单位完全成本三维量化决策模型,实现了双因素对完全成本目标影响程度定量化多维度展示,可直观判断目标完全成本的实现概率,支撑致密气开发过程中效益风险预警与最优决策。 展开更多
关键词 致密气 单位完全成本 三维量化模型 蒙特卡罗模拟 敏感性分析
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基于深度强化学习的蜂窝连接无人机轨迹优化方法及仿真 认领 引用
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作者 李胜昌 张振峡 +3 位作者 王乐和 吴佳华 于果 孟祥禄 《电子技术应用》 2026年第4期29-37,共9页
蜂窝连接无人机(cellular-connected UAV)在5G网络中展现出巨大潜力。针对其在执行通信任务时需保持稳定地面基站连接的问题,研究了无人机轨迹优化。目标是在给定区域内,使无人机从起点到终点的飞行过程中联合最小化任务完成时间与通信... 蜂窝连接无人机(cellular-connected UAV)在5G网络中展现出巨大潜力。针对其在执行通信任务时需保持稳定地面基站连接的问题,研究了无人机轨迹优化。目标是在给定区域内,使无人机从起点到终点的飞行过程中联合最小化任务完成时间与通信中断时间,并最大化通信吞吐量。由于该问题具有非凸性,采用基于多步学习的竞争性双深度Q网络(Dueling Double Deep Q Network, D3QN)算法求解,通过无人机与地面基站的交互学习实现自适应轨迹优化。仿真结果表明,与直飞策略相比,该方法将任务完成时间缩短了28%,通信中断时长降低了42%,系统平均吞吐量提升了35%,在任务效率、通信稳定性和系统吞吐量等方面均实现显著优化。 展开更多
关键词 无人机 蜂窝通信 深度强化学习 轨迹优化 竞争性双深度Q网络
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Enhancing performance of proton ceramic fuel cells through fluorine-doped perovskite oxides 认领 引用 被引量:2
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作者 Wen-Huai Li Yong-Xin Li +9 位作者 Yan Yang Yang-Feng Song Wen-Xin Liu Wei-Feng Chen Yao-Ji Chen Feng-Ping Yu Chun-Liang Ge Yu Guo Ran Ran Wei Zhou 《Rare Metals》 SCIE EI CAS CSCD 2025年第4期2405-2415,共11页
Proton ceramic fuel cell efficiently converts chemical energy into electrical energy,representing a pivotal component of future energy systems.However,its current performance is hindered by limitations in cathode and ... Proton ceramic fuel cell efficiently converts chemical energy into electrical energy,representing a pivotal component of future energy systems.However,its current performance is hindered by limitations in cathode and electrolyte materials,thereby impeding commercialization.Anion doping emerges as a promising strategy to enhance the electrochemical efficiency of perovskite-based cathodes and electrolytes.However,integrating this approach within a single-cell structure still requires further research.In this study,F-doped perovskite oxides BaCo0.4Fe0.4Zr0.1Y0.1O2.9-δF0.1(BCFZYF)and BaZr0.1Ce0.7Y0.1Yb0.1O2.9-δF0.1(BZCYYbF)were synthesized for use as the cathode and electrolyte,respectively,in proton ceramic fuel cells.Our findings demonstrate that F-doped perovskite oxides exhibit superior electrochemical performance and enhanced structural stability.Furthermore,doping both electrodes and electrolytes with F ions improves their interfacial compatibility.The cell configuration BCFZYF|BZCYYbF|Ni-BZCYYbF achieved a peak power density of 998 mW·cm−2at 650℃using H2as fuel,and it maintained stable operation for over 400 h at 550℃with a current density of 400 mA·cm−2.This research underscores an effective strategy for enhancing the performance and durability of proton ceramic fuel cells. 展开更多
关键词 Proton ceramic fuel cell Perovskite oxides Fluorine doped Ion migration
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Geographical distribution and characterization of Jingmen tick virus in wild boars in China 认领 引用 被引量:1
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作者 Tong Wang Yu Guo +6 位作者 Yu Xu Heting Sun Peng Peng Siyuan Qin Guoqiang Zhu Changchun Tu Zhongzhong Tu 《Virologica Sinica》 SCIE CAS CSCD 2025年第1期137-140,共4页
Dear Editor,In recent decades,vector-transmitted emerging and re-emerging diseases pose public health issues around the world,in which emerging tick-borne viruses(TBVs)have played a major role since they are widely di... Dear Editor,In recent decades,vector-transmitted emerging and re-emerging diseases pose public health issues around the world,in which emerging tick-borne viruses(TBVs)have played a major role since they are widely distributed.TBVs have a wide range of hosts,including humans,livestock and rodents,with some of them able to cause severe diseases in human and domestic animals,such as Jingmen tick virus(JMTV)(Qin et al.,2014),tick-borne encephalitis virus(TBEV)(Xing et al.,2017),and Alongshan virus(ALSV)(Wang et al.,2019).Of the merging TBVs,JMTV is a novel pathogen that was first identified in Rhipicephalus microplus collected from the Jingmen city of Hubei province,China in 2010(Qin et al.,2014). 展开更多
关键词 Wild boars alongshan virus alsv wang Host range Jingmen tick virus China Public health issues Emerging tick borne viruses Geographical distribution
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Multi-Scale Time Series Segmentation Network Based on Eddy Current Testing for Detecting Surface Metal Defects 认领 引用 被引量:1
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作者 Xiaorui Li Xiaojuan Ban +6 位作者 Haoran Qiao Zhaolin Yuan Hong-Ning Dai Chao Yao Yu Guo Mohammad S.Obaidat George Q.Huang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2025年第3期528-538,共11页
In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh enviro... In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh environment leads to significant variations in the shape and size of the defects.To address this challenge,we propose the multivariate time series segmentation network(MSSN),which adopts a multiscale convolutional network with multi-stage and depth-separable convolutions for efficient feature extraction through variable-length templates.To tackle the classification difficulty caused by structural signal variance,MSSN employs logarithmic normalization to adjust instance distributions.Furthermore,it integrates classification with smoothing loss functions to accurately identify defect segments amid similar structural and defect signal subsequences.Our algorithm evaluated on both the Mackey-Glass dataset and industrial dataset achieves over 95%localization and demonstrates the capture capability on the synthetic dataset.In a nuclear plant's heat transfer tube dataset,it captures 90%of defect instances with75%middle localization F1 score. 展开更多
关键词 Eddy current testing nondestructive testing semantic segmentation time series analysis
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Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora 认领 引用
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作者 Yaxi Zhou Diandian Wang +5 位作者 Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第2期758-768,共11页
The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The... The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium(DSS)-induced colitis.The findings suggested that SPP effectively eased ulcerative colitis(UC)symptoms in mice by decreasing disease activity index,ameliorating histopathological injury,and decreasing serum and colonic markers of inflammation.In addition,our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1(ZO-1),claudin-1,claudin-3,occludin,and adherens junction protein E-cadherin1.Further,SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut.These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis. 展开更多
关键词 Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids
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Correction:Phosphorus-caused embrittlement of SA508Gr.4N reactor pressure vessel steel and its suppression by rare-earth cerium 认领 引用
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作者 Yu Guo Kai Wang +1 位作者 Wen-shuai Liu Xiao-ping Zhu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第12期4530-4530,共1页
Correction to:J.Iron Steel Res.Int.http://gffzzd3cc09b8251d45dfs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/10.1007/s42243-025-01460-1 The publication of this article unfortunately contained mistakes.The revised and accepted dates were not correct.The corrected dates are gi... Correction to:J.Iron Steel Res.Int.http://gffzzd3cc09b8251d45dfs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/10.1007/s42243-025-01460-1 The publication of this article unfortunately contained mistakes.The revised and accepted dates were not correct.The corrected dates are given below. 展开更多
关键词 suppression SA GR N corrected dates phosphorus embrittlement reactor pressure vessel steel rare earth cerium revised accepted dates
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Manual acupuncture alleviates neuronal damage condition after traumatic brain injury by inhibiting the NF-κB pathway 认领 引用
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作者 Min-an CHEN Jia-yan CHEN +7 位作者 Ke-ren ZHAO Hai ZENG Lu-xi CAO Xiao-wen CHEN Yi-min ZHANG Peng QING Yu GUO Ming-min ZHU 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2025年第4期376-383,共8页
Objective:Acupuncture can effectively alleviate neuronal damage following traumatic brain injury(TBI);however,the underlying mechanisms remain unclear.This study aimed to investigate the putative mech-anisms of acupun... Objective:Acupuncture can effectively alleviate neuronal damage following traumatic brain injury(TBI);however,the underlying mechanisms remain unclear.This study aimed to investigate the putative mech-anisms of acupuncture by examining the expression of Toll-like receptor 4(TLR4),inhibitor ofκB kinase(IKK)complex,nuclear factorκB(NF-κB)p65,and microglial polarization.Methods:Specific pathogen-free(SPF)male Sprague-Dawley(SD)rats were divided into normal,TBI,and acupuncture groups,with 10 rats per group.Except for the normal group,the rat TBI model was estab-lished using Feeney’s free-fall impact method.The acupuncture group received acupuncture intervention at the acupoints“Yamen(GV15)”,“Fengfu(GV16)”,“Baihui(GV20)”,“Shuigou(GV26)”,and“Hegu(LI4)”,once daily for 15 min per session for 5 days.The normal and TBI groups received no treatment,but were restrained for 15 min.Neurological dysfunction was assessed using the modified Neurological Severity Score(mNSS)on Days 1 and 5.Nissl staining and immunohistochemical staining for microglial M1(CD86)and M2(CD206)markers were used to observe the histopathological changes in the cortical tissue of TBI rats.Western blotting was employed to detect the expression of TLR4,IKKα+IKKβ,p-IKKα/β,p-IκBα,and NF-κB p65.Results:(1)Compared to the normal group,the TBI group showed a significant increase in the mNSS score(P<0.01).Nissl staining revealed disorganized neuronal cells,pyknotic nuclei,and fragmented and significantly decreased Nissl bodies.Immunohistochemistry demonstrated significantly increased ex-pression of both CD86+ and CD206+cells in the injured area(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα/β,and p-IκBα in the cerebral cortex was significantly upregulated(P<0.05 or P<0.01),and NF-κB p65 expression in the nuclear protein fraction was increased(P<0.01).(2)Compared to the TBI group,the acupuncture group exhibited a significant decrease in the mNSS score(P<0.01).Nissl staining revealed improved neuronal structure,reduced number of pyknotic nuclei,and a significant increase in Nissl bodies.Immunohistochemistry indicated significantly decreased CD86+cell expression(P<0.01)and significantly increased CD206+cell expression(P<0.01).Protein expression of TLR4,IKKα+IKKβ,p-IKKα,and p-IκBα in the cerebral cortex was significantly reduced(P<0.05),and NF-κB p65 expression in the nuclear protein fraction was significantly decreased(P<0.01).Conclusions:Acupuncture downregulates the expression of TLR4 and IKKα+IKKβ,inhibits the phospho-rylation of IKKα/β and IκBα,reduces the nuclear expression of NF-κB p65,suppresses microglial M1 polarization,indirectly promotes M2 polarization,ameliorates neuronal damage after TBI,and promotes neural repair. 展开更多
关键词 Acupuncture Traumatic brain injury Microglia Ikk-complex-associated protein NF kappa B p65
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Phosphorus-caused embrittlement of SA508Gr.4N reactor pressure vessel steel and its suppression by rare-earth cerium 认领 引用
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作者 Yu Guo Kai Wang +1 位作者 Wen-shuai Liu Xiao-ping Zhu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第4期1034-1044,共11页
The effect of rare-earth cerium on impurity P-induced embrittlement for an advanced SA508Gr.4N reactor pressure vessels steel is investigated by virtue of microstructural characterization,Auger electron spectroscopy(A... The effect of rare-earth cerium on impurity P-induced embrittlement for an advanced SA508Gr.4N reactor pressure vessels steel is investigated by virtue of microstructural characterization,Auger electron spectroscopy(AES),and spin-polarized density functional theory(DFT)calculations.The ductile-to-brittle transition temperatures(DBTTs)are evaluated by Charpy impact testing,and grain boundary segregation(GBS)of P is quantified by AES.Trace addition of Ce can effectively reduce GBS level of P,thereby substantially decreasing the embrittlement induced by P.A linear correlation between DBTT(℃)and GBS level of P(Cp,at.%)is observed for both undoped and Ce-doped samples,being expressed as DBTT=13.13Cp-335.70(undoped)and DBTT=12.67Cp-350.78(Ce-doped).In the absence of GBS of P,the incorporation of Ce appears to play a pivotal role in augmenting the intrinsic toughness.These results imply that the impact of Ce on impurity P-induced embrittlement may be attributed to a combination of increasing the intrinsic toughness and lowering GBS of P.DFT calculations indicate that there is a negligible interaction between Ce and P in the ternary alloy,and thus GBS of P and Ce is mainly site-competitive. 展开更多
关键词 Reactor pressure vessel steel Embrittlement Rare-earth Ce Auger electron spectroscopy Grain boundary segregation
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基于自适应采集函数的丙烯酸生产过程代理模型 认领 引用
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作者 曾祥宇 薄翠梅 +2 位作者 喻果 张泉灵 高福荣 《控制理论与应用》 EI CAS CSCD 北大核心 2026年第7期1584-1594,共11页
丙烯酸生产过程机理建模方法精度高但计算时间长,采用数据驱动的代理模型方法可以降低其计算成本,如何提高代理模型精度成为数据驱动建模关键.因此,本文提出了一种新的基于自适应采集函数的高斯过程,首先,基于加权的多邻近期望改进策略... 丙烯酸生产过程机理建模方法精度高但计算时间长,采用数据驱动的代理模型方法可以降低其计算成本,如何提高代理模型精度成为数据驱动建模关键.因此,本文提出了一种新的基于自适应采集函数的高斯过程,首先,基于加权的多邻近期望改进策略增大不确定区域的采样概率;然后,引入稀疏度避免其过度采样;最后,通过指数衰减策略自适应调整采集函数的全局与局部搜索能力,从而逐步提高代理模型精度.通过在9个测试函数和丙烯酸生产过程上进行对比实验,实验结果表明所提出的算法有效地提升了代理模型的精度,验证了算法的有效性. 展开更多
关键词 丙烯酸生产过程 加权多邻近期望改进 稀疏度 代理模型 自适应采集函数
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电针改善急性呼吸窘迫综合征患者呼吸力学的临床研究 认领 引用
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作者 葛凡 赵鑫国 +5 位作者 徐琳忆 高靓 左小溪 于果 鲁俊 张海东 《南京中医药大学学报》 CAS CSCD 北大核心 2026年第5期734-742,共9页
目的观察电针对急性呼吸窘迫综合征患者呼吸力学的影响。方法选取2024年2月至2025年12月于江苏省中医院重症医学科住院治疗的急性呼吸窘迫综合征患者92例,随机分为试验组、对照组各46例。试验组在标准化综合治疗基础上加用电针治疗,对... 目的观察电针对急性呼吸窘迫综合征患者呼吸力学的影响。方法选取2024年2月至2025年12月于江苏省中医院重症医学科住院治疗的急性呼吸窘迫综合征患者92例,随机分为试验组、对照组各46例。试验组在标准化综合治疗基础上加用电针治疗,对照组在标准化综合治疗基础上加用安慰针模拟干预,每日1次,每次30 min,连续治疗7 d。比较2组患者的血气分析、呼吸力学、临床疗效、机械通气时间、拔管率、器官功能障碍、出院率和60 d存活率,记录治疗期间不良反应发生情况。结果治疗7 d后,试验组氧合指数、氧分压、静态肺顺应性、总有效率及28 d拔管率均显著优于对照组(P<0.05,P<0.01),氧合指数改善是拔管成功的独立预测因素(P<0.05)。试验期间,2组患者均未出现与针灸治疗相关的不良反应。结论电针可通过调控急性呼吸窘迫综合征患者的呼吸力学和气体交换从而缓解患者临床症状、提高拔管率,具有较好的临床价值。 展开更多
关键词 急性呼吸窘迫综合征 电针 呼吸力学 肺顺应性 氧合指数 炎症 临床研究
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