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Unveiling Xuanshen decoction:A novel approach to combat slow transit constipation 认领 引用 被引量：1
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作者 Xing-Lin Zeng Lian-Jun Zhu +2 位作者 Yu Zhang Xiang-Dong Yang Yu-Jun Zhu 《World Journal of Gastroenterology》 SCIE CAS 2025年第30期126-143,共18页
BACKGROUND Xuanshen decoction(XSD)is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation(STC).However,its specific therapeutic mechanism remains to be characterized.A... BACKGROUND Xuanshen decoction(XSD)is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation(STC).However,its specific therapeutic mechanism remains to be characterized.AIM To investigate the mechanism of XSD for STC,we combined network pharmacology prediction,molecular docking analysis,and in vivo studies.METHODS The therapeutic effects of XSD on loperamide-induced STC in rats were assessed through 24-hour fecal number,fecal moisture content,and intestinal propelling rate.Hematoxylin–eosin and Alcian blue/periodic acid-Schiff staining were applied to analyze colonic mucosa for histopathological presentation and mucin production.Next,the mechanism of action of XSD for STC was elucidated through network pharmacology and molecular docking analyses,and the findings were validated by the animal experiments.RESULTS XSD significantly alleviated the symptoms of STC in rats.Relative to the STC rats,in the medium-dose XSD and high-dose XSD rats,stem cell factor,C-kit,phosphophosphoinositide 3-kinase/phosphoinositide 3-kinase,phospho-protein kinase B/protein kinase B,catalase,and superoxide dismutase were substantially upregulated(P<0.01);nuclear factor erythroid 2-related factor 2(nuclear/cytoplasmic)and B-cell lymphoma 2(Bcl-2)were increased(P<0.05),while cleaved caspase-3,Bcl-2-associated X protein(Bax)/Bcl-2,and malondialdehyde were significantly reduced(P<0.01).Heme oxygenase-1 and glutathione peroxidase in the high-dose XSD group were significantly increased(P<0.01),and Bax was statistically lowered(P<0.01);glutathione peroxidase in the medium-dose XSD group was increased(P<0.05),while Bax was reduced(P<0.05).CONCLUSION XSD may inhibit oxidative-stress-induced apoptosis in interstitial cells of Cajal by stimulating the phosphoinositide 3-kinase/protein kinase Buclear factor erythroid 2-related factor 2 pathway,thereby effectively treating STC. 展开更多
关键词 Slow transit constipation Oxidative stress Network pharmacology Experimental verification Molecular docking
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Amino-regulated charge separation in MOF/CdS heterostructures for boosted photocatalytic hydrogen evolution 认领 引用
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作者 Ya-Ning Liu Yu-Jun Zhu +11 位作者 Song Yang Zhong-Hua Sun Yi Cheng Meng-Qi Zheng Yu-Pei Zhao Cheng Lian Yun-Fei Bu Vladimir Guskov Ming-Yang He Hua-Zhang Guo Liang Wang Zhi-Hui Zhang 《Rare Metals》 SCIE EI CAS CSCD 2025年第12期10215-10226,共12页
Effective charge separation is crucial for efficient pho tocataly tic hydrogen production in metal-organic frameworks(MOFs).Herein,CdS-modified MOFs composites Y-TPTC/CdS and Y-TPTC-NH2/CdS were synthesized with or... Effective charge separation is crucial for efficient pho tocataly tic hydrogen production in metal-organic frameworks(MOFs).Herein,CdS-modified MOFs composites Y-TPTC/CdS and Y-TPTC-NH2/CdS were synthesized with ordered porous structures and abundant active sites.Under visible light irradiation,Y-TPTC/CdS and Y-TPTC-NH2/CdS exhibit optimal proportional hydrogen production rates of 1936 and 5650 μmol g-1-h-1,respectively,representing 9.4 and 27.1 times higher than that of pure CdS(205 μmol g-1 h-1).The introduction of amino groups effectively suppressed recombination of photogenerated charge carriers,facilitating more efficient charge transfer and significantly boosting photocatalytic hydrogen production activity.This work provides important insights for developing advanced composite photocatalysts with improved charge separation kinetics for enhanced solar-to-hydrogen conversion efficiency. 展开更多
关键词 Metal-organic frameworks Amino functionalization Heterostructure Charge separation Photocatalytic hydrogen production
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On Local Constancy of Topological Entropy for Certain Partially Hyperbolic Diffeomorphisms 认领 引用
3
作者 Lin WANG Xin-sheng WANG Yu-jun ZHU 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2018年第2期249-253,共5页
Let f ： M → M be a partially hyperbolic diffeomorphism on a closed Riemannian manifold with uniformly compact center foliation. We show that if the center foliation of f is of dimension one then the topological entr... Let f ： M → M be a partially hyperbolic diffeomorphism on a closed Riemannian manifold with uniformly compact center foliation. We show that if the center foliation of f is of dimension one then the topological entropy is constant on a small C1 neighborhood of f. 展开更多
关键词 partially hyperbolic diffeomorphism topological entropy local constancy
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