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Upregulation of Zip14 correlates with induction of endoplasmic reticulum stress(ERS)in hypertrophied hearts of Dahl saltsensitive rats 认领 引用
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作者 JINYONG HUANG TIANMING TENG +5 位作者 BO BIAN YUCHEN XUE LONGFEI HUANG ZHELONG XU QING YANG YUEMIN SUN 《BIOCELL》 SCIE 2022年第3期667-675,共9页
Zinc is a trace element involved in maintaining cellular structure and function.Although zinc is associated with left ventricular hypertrophy(LVH),there have been few reports on this association.This study aimed to ev... Zinc is a trace element involved in maintaining cellular structure and function.Although zinc is associated with left ventricular hypertrophy(LVH),there have been few reports on this association.This study aimed to evaluate the correlation between Zip14 and expression of endoplasmic reticulum stress(ERS)associated molecules in hypertrophied hearts of rats.Dahl salt-sensitive rats were fed a high salt diet to establish a left ventricular hypertrophy(LVH)rat model.RT-PCR was used to determine Zip14,activating transcription factor(ATF4),ATF6,x-box-binding protein 1(xBP1),C/EBP homologous protein(CHOP),immunoglobulin-binding protein(BiP)mRNA expression.Western blotting was used to evaluate Zip14,BiP,CHOP,GAPDH expression.Zinc levels were measured by Inductively Coupled Plasma Optical Emission Spectroscopy.The results indicated that compared with the Control group,Zip14 mRNA and protein expression in LVH rat hearts were markedly increased(P<0.01).Zinc content in rat heart tissue was significantly increased in the LVH group compared with the Control group(P<0.05).ATF4,ATF6,xBP1 mRNA expressions were increased in LVH rat hearts compared with Control hearts(P<0.001).Compared with the Control group,CHOP and BiP mRNA and protein expression were markedly increased in LVH rat hearts(P<0.05,P<0.01).Linear regression models showed that Zip14 mRNA expressions were positively correlated with zinc concentration,ATF4 and ATF6 mRNA expressions in Control hearts(P=0.0005,P=0.0052,P=0.0026,respectively)and LVH rat hearts(P<0.0001,P=0.0119,P=0.0033,respectively).In conclusion,upregulation of Zip14 in LVH rat hearts correlated with zinc accumulation and induction of ERS. 展开更多
关键词 Zinc Zip14 Endoplasmic reticulum stress(ERS) Left ventricular hypertrophy(LVH) Rat hearts
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Basic research and clinical progress of sepsis-associated encephalopathy 认领 引用 被引量：12
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作者 Ying Huang Ruman Chen +2 位作者 Lai Jiang Siyuan Li Yuchen Xue 《Journal of Intensive Medicine》 2021年第2期90-95,共6页
Sepsis-associated encephalopathy(SAE),a major cerebral complication of sepsis,occurs in 70%of patients admitted to the intensive care unit(ICU).This condition can cause serious impairment of consciousness and is assoc... Sepsis-associated encephalopathy(SAE),a major cerebral complication of sepsis,occurs in 70%of patients admitted to the intensive care unit(ICU).This condition can cause serious impairment of consciousness and is associated with a high mortality rate.Thus far,several experimental screenings and radiological techniques(e.g.,electroencephalography)have been used for the non-invasive assessment of the structure and function of the brain in patients with SAE.Nevertheless,the pathogenesis of SAE is complicated and remains unclear.In the present article,we reviewed the currently available literature on the epidemiology,clinical manifestations,pathology,diagnosis,and management of SAE.However,currently,there is no ideal pharmacological treatment for SAE.Treatment targeting mitochondrial dysfunction may be useful in the management of SAE. 展开更多
关键词 Sepsis-associated encephalopathy Long-term cognitive dysfunction Cerebral microvasculature damage
Watt-level acousto-optically Q-switched Pr:YLF laser at 639 nm 认领 引用 被引量：2
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作者 薛喻宸 张瑞松 +3 位作者 戴征东 王中玉 许惠英 蔡志平 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第1期76-83,共8页
We present a study on a watt-level acousto-optically Q-switched Pr:YLF laser at three different repetition rates(10 kHz,20 kHz,and 50 kHz)for the first time,to the best of our knowledge.The corresponding average outpu... We present a study on a watt-level acousto-optically Q-switched Pr:YLF laser at three different repetition rates(10 kHz,20 kHz,and 50 kHz)for the first time,to the best of our knowledge.The corresponding average output powers and pulse widths were measured to be 1.14 W,1.2 W,and 1.32 W,and 40 ns,52 ns,and 80 ns,respectively.A maximum pulse energy of0.11 mJ was obtained,corresponding to a peak power of up to 2.8 kW at a repetition rate of 10 kHz.The simulated dynamics of a fast Q-switched Pr:YLF laser is in agreement with the experiment.The laser's ability to generate stable pulses with high peak power and short pulse width makes it highly desirable for various practical applications,such as laser machining and material processing. 展开更多
关键词 red pulsed laser Pr:YLF diode pump acousto-optical Q switching
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Watt-level laser operation of Pr3+:YLF at 696 and 698 nm 认领 引用 被引量：1
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作者 曹伟航 戴征东 +5 位作者 方润 王中玉 薛喻宸 肖波 许惠英 蔡志平 《Chinese Optics Letters》 SCIE EI CAS CSCD 2023年第4期59-64,共6页
We report continuous-wave deep red lasers at 696.6 and 698.6 nm in a Pr3+:YLF crystal pumped by an InGaN laser diode.A Lyot filter was inserted into the cavity as a birefringent filter to select wavelength;the lase... We report continuous-wave deep red lasers at 696.6 and 698.6 nm in a Pr3+:YLF crystal pumped by an InGaN laser diode.A Lyot filter was inserted into the cavity as a birefringent filter to select wavelength;the lasers at 696.6 and 698.6 nm were obtained with a maximum output power of 1.36 and 3.11 W,separately.To the best of our knowledge,the output powers of these two lasers are the highest to date,and this is the first scaling of the output power of the Pr3+:YLF laser to the watt level at around 696 nm.In addition,the corresponding theoretical analysis and simulation were carried out to explain the experimental phenomena. 展开更多
关键词 Pr3+:YLF crystal deep red lasers Lyot filter
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