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MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease 认领 引用 被引量：2
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作者 Meiyan Zhang Xiaoyan Lan +6 位作者 Yue Gao Shen Li Guanda Qiao Yajie Liang Miroslaw Janowski Piotr Walczak Chengyan Chu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2425-2432,共8页
Cerebral small vessel disease is a major vascular contributor to cognitive impairment and dementia.However,there remains a lack of effective preventative or therapeutic regimens for cerebral small vessel disease.In th... Cerebral small vessel disease is a major vascular contributor to cognitive impairment and dementia.However,there remains a lack of effective preventative or therapeutic regimens for cerebral small vessel disease.In this study,we investigated the potential therapeutic effects of MCC950,a selective NOD-like receptor family pyrin domain-containing protein 3 inhibitor,on cerebral small vessel disease pathogenesis and cognitive decline in spontaneously hypertensive rats.Our results showed that chronic administration of MCC950(10 mg/kg)to spontaneously hypertensive rats inhibited NOD-like receptor family pyrin domain-containing protein 3 inflammasome activation,thereby considerably suppressing the production of pyroptosis executive protein gasdermin D and pro-inflammatory factors,including interleukin-1βand-18.A decrease in astrocytic and microglial activation was also observed.We also found that MCC950 significantly inhibited autophagy.More importantly,behavioral assessment indicated that MCC950 administration ameliorated impaired neurocognitive function,which was associated with improvements in neuropathological hallmarks in the cerebral small vessel disease brain,such as blood‒brain barrier breakdown,white matter damage,and endothelial dysfunction.Thus,our findings revealed that the NOD-like receptor family pyrin domain-containing protein 3 inflammasome is a key contributor to the onset or progression of cerebral small vessel disease and suggested the potential of NOD-like receptor family pyrin domain-containing protein 3-based therapy as a potential novel strategy for treating cerebral small vessel disease. 展开更多
关键词 astrocyte autophagy blood-brain barrier cerebral small vessel disease cognitive function endothelial cells microglia neuroinflammation NLRP3 inflammasome white matter
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Phenotype–Target Coupled Drug Screening:A High-Efficiency Framework for Innovative Drug Discovery from CHMs 认领 引用 被引量：2
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作者 Wei Zhou Yue Gao 《Engineering》 SCIE EI CSCD 2026年第2期10-13,共4页
Chinese herbal medicines(CHMs)serve as the cornerstone of traditional Chinese medicine(TCM)practices and are vital sources of inspiration for novel drug discovery.Many landmark drugs,including artemisinin,ephedrine,bi... Chinese herbal medicines(CHMs)serve as the cornerstone of traditional Chinese medicine(TCM)practices and are vital sources of inspiration for novel drug discovery.Many landmark drugs,including artemisinin,ephedrine,bicyclol,berberine,and dl-3-nbutylphthalide,originated from CHMs.Nevertheless,only 23.5%of the new drugs approved by the US Food and Drug Administration(FDA)over the past four decades have stemmed from botanical drugs,natural products,or their derivatives[1]. 展开更多
关键词 natural products phenotype target coupled drug screening botanical drugsnatural Chinese Herbal Medicines chinese herbal medicines chms serve novel drug discoverymany traditional chinese medicine tcm practices botanical drugs
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Corrigendum to“Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation”[J.Pharm.Anal.13(2023)11–23] 认领 引用
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作者 Ningning Wang Entao Li +9 位作者 Huifang Deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期309-311,共3页
The authors regret the unintentional error in the use of the GAPDH band in the original Fig.5C.The corrected figure is provided as the new Fig.5C below.This change does not affect the conclusions of the paper.
关键词 corrected figure inosine anti inflammatory TBK phosphorylation SARS CoV GAPDH acute lung injury gapdh band
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Advances in extraction,purification,and pharmacological mechanisms of calycosin:a comprehensive review 认领 引用
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作者 Keke Liang Chao Chen +8 位作者 Liang Xu Shuhe Ma Yanlin Ta Renjie Wang Chenrong Xiao Xianxie Zhang Feiran Hao Yue Gao Maoxing Li 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第6期672-695,共24页
Calycosin,a pivotal isoflavonoid active constituent derived from Astragalus membranaceus,is designated as a key marker compound for the quality assessment of Astragalus and its products in the Pharmacopoeia of the Peo... Calycosin,a pivotal isoflavonoid active constituent derived from Astragalus membranaceus,is designated as a key marker compound for the quality assessment of Astragalus and its products in the Pharmacopoeia of the People’s Republic of China(2020 Edition).It exhibits a broad spectrum of pharmacological activities and holds significant potential for clinical application.This article systematically reviews the research progress on calycosin.In terms of extraction,isolation,and purification,techniques such as flash extraction and hydrolytic extraction enable efficient enrichment of the compound,whereas methods such as macroporous adsorption resin and high-speed counter-current chromatography allow for high-purity preparation.The biosynthetic pathways of calycosin encompass the phenylpropanoid pathway in planta,the chemical“one-pot”method in vitro,and synthesis via microbial cell factories,offering diverse strategies for large-scale production.Structural derivatization,particularly through modification of the 7-and 3′-hydroxyl groups,significantly enhances its solubility and antitumor activity.With respect to pharmacological mechanisms,calycosin exerts multi-pathway and low-toxicity effects in diseases such as inflammation,cancer,and neural injury by modulating multiple signaling pathways,including NF-κB,PI3K/AKT,and MAPK.Furthermore,pharmacokinetic studies indicate that its absorption depends on deglycosylation,that it undergoes substantial hepatic first-pass metabolism,and that its tissue distribution is organ-specific.Safety evaluations suggest low toxicity at therapeutic concentrations.This review aims to clarify the core issues concerning the translation of basic research on calycosin into clinical practice,thereby providing a theoretical foundation for subsequent development. 展开更多
关键词 Calycosin Astragalus membranaceus Pharmacological activities Structural derivatization Biosynthesis
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Expansion of Spartina alterniflora at its northernmost distribution limit in China and its impacts on wetland carbon and nitrogen 认领 引用
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作者 Lin Cheng Xihan Liu +5 位作者 Xiang Gao Henan Meng Leigang Sun Wenxin Zhu Yue Gao Dengpan Xiao 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2026年第4期146-163,共18页
In China,the northernmost distribution area of the invasive species Spartina alterniflora is found in the city of Tangshan,Hebei Province.To understand its expansion mechanisms and ecological impacts in Tangshan,this ... In China,the northernmost distribution area of the invasive species Spartina alterniflora is found in the city of Tangshan,Hebei Province.To understand its expansion mechanisms and ecological impacts in Tangshan,this study investigated the expansion dynamics of S.alterniflora and its impacts on the carbon(C)and nitrogen(N)contents of plants and soil based on multi-source remote sensing data,a random forest classification model,and the Google Earth Engine platform data combined with field investigations.The results show that S.alterniflora in Tangshan exhibited a trend of rapid expansion from 2010 to 2023 at a rate of 7.85 hm2/a.Furthermore,the rate of expansion in Tangshan was notably faster when compared with those reported in other regions in China.Rapid expansion was primarily influenced by the accelerated sedimentation occurring on the tidal flats against the backdrop of large-scale reclamation.Field data revealed positive correlations between the colonization age of S.alterniflora and stem width as well as the total organic carbon(TOC)and total nitrogen(TN)contents in soil;conversely,colonization age demonstrated an inverse relationship with the soil grain size.Notably,compared with S.alterniflora in mid-latitude regions,S.alterniflora in Tangshan exhibited increased stem and leaf TN content,as well as elevated soil TOC and TN levels;however,the finding revealed lower aboveground biomass and total carbon content within plants in Tangshan than has been reported in other regions.The findings from Tangshan are similar to those reported for low-latitude areas.This study offers valuable insights into coastal wetland management under future scenarios with the northward expansion of S.alterniflora. 展开更多
关键词 Tangshan Spartina alterniflora expansion dynamics carbon nitrogen
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Sphenopalatine ganglion stimulation:Clinical applications and innovative development 认领 引用
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作者 Ling-li QIN Yue GAO +5 位作者 Jian-wu SHEN Ran LUO Dian CHEN Wan-ying XIA Jin-sheng YANG Lu ZHANG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第1期61-66,共6页
The sphenopalatine ganglion(SPG)is a critical parasympathetic ganglion located beneath the maxillary nerves.Its anatomical structure and function play key roles in the regulation of cerebral blood vessels,the autonomi... The sphenopalatine ganglion(SPG)is a critical parasympathetic ganglion located beneath the maxillary nerves.Its anatomical structure and function play key roles in the regulation of cerebral blood vessels,the autonomic nervous system,and various headache-related disorders.In recent years,SPG stimulation(SPGS)has been widely applied in both invasive and acupuncture-mediated clinical practice.This paper outlines the current clinical applications of SPGS in treating conditions such as headaches,strokes,and rhinitis,and explores how innovative technologies,including ultrasound-guided techniques and singleuse sterile electrode acupuncture needles,may enhance therapeutic efficacy.The potential future development of SPGS in the field of neuromodulation is also discussed. 展开更多
关键词 Sphenopalatine ganglion Sphenopalatine ganglion stimulation technology Neuromodulation Single-use sterile electrode acupuncture needle
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Simultaneous removal of tetracycline and antibiotic resistant bacteria/genes in UV-LED/H2O2 system:Competitive interactions and wavelength dependence 认领 引用
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作者 Jie Wang Jijie Zhang +7 位作者 Defang Ma Zhenxiang Sun Yan Wang Qinyan Yue Yanwei Li Yue Gao Baoyu Gao Xing Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期655-661,共7页
The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alon... The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H2O2 system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R2=0.831)in UV-LED alone system and with·OH yield(R2=0.999)in UV-LED/H2O2 system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R2=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H2O2 system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H2O2 technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H2O2 system,providing a promising approach for their simultaneous removal while ensuring energy efficiency. 展开更多
关键词 UV-LED/H2O2 ARB/ARGs Wavelength dependence Competition Simultaneous removal
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Deciphering the flocculation mechanism of cellulose-modified polymers for antibiotic and co-pollutant removal:Structural determinants from structure-activity relationships 认领 引用
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作者 Binjie Yan Chenxu Wang +8 位作者 Qiyun Feng Chao Niu Wenbin Zhao Mengjiao Feng Beibei Liu Yue Gao Qinyan Yue Kangying Guo Baoyu Gao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期644-655,共12页
The widespread use of antibiotics has led to their persistent accumulation in aquatic environments.Although flocculation is cost-effective,traditional flocculants exhibit limited removal efficiency for antibiotics.To ... The widespread use of antibiotics has led to their persistent accumulation in aquatic environments.Although flocculation is cost-effective,traditional flocculants exhibit limited removal efficiency for antibiotics.To address this problem,a novel cellulose-based flocculant(CE-DMC)was synthesized from paper pulp rejects.The methacryloxyethyltrimethyl ammonium chloride(DMC)monomer was successfully grafted onto the cellulose backbone with a grafting rate of 64%,endowing CE-DMC with high positive charge density(+71.1 mV at pH 6)and a branched architecture.Flocculation experiments demonstrated the superior performance of CE-DMC in removing four representative antibiotics.Notably distinct removal efficiencies were achieved:ofloxacin exhibited the highest removal(52.6%),followed by sulfamethoxazole(36.4%),norfloxacin(30.9%),and amoxicillin(29.8%),reflecting differential interaction mechanisms with the adsorbent.The flocculation mechanism of CE-DMC could be concluded as follows:(1)charge neutralization via quaternary ammonium groups of DMC chains,(2)n-π*electron donor-acceptor interactions andπ-π*conjugated interactions mediated by benzene rings and furan rings of cellulose skeleton,and(3)hydrogen bonding force provided by the hydroxyl group from the cellulose skeleton and the DMC chains.Notably,coexisting humic acid(HA)and kaolin enhanced antibiotic removal efficiency by forming large composite pollutants via n-π*electron donor-acceptor interactions,hydrogen bonding forces,andπ-π*conjugated interactions.CE-DMC synergistically removed antibiotics and co-pollutants,with its flocculation mechanism elucidated through structure-activity relationships and structural determinants.This work advances the rational design of natural polymer-based flocculants for multi-mechanistic contaminant removal. 展开更多
关键词 Cellulose-based flocculants Paper pulp rejects Antibiotic removal Composite pollutants Flocculation mechanism
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Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care 认领 引用
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作者 Longhui Hao Yi Zhang +8 位作者 Ying Sun Yanqi Han Jun Ye Hongliang Wang Lili Gao Dong Wang Yue Gao Yanfang Yang Yuling Liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期147-160,共14页
Compared to synthetic chemical compounds,plant extracts derived from natural sources have emerged as the"new favorites"in the treatment and care of skin diseases due to their distinct advantages,including be... Compared to synthetic chemical compounds,plant extracts derived from natural sources have emerged as the"new favorites"in the treatment and care of skin diseases due to their distinct advantages,including being environmentally friendly,sustainable,and safe.However,challenges such as poor solubility,limited permeability,and the barrier function of the stratum corneum significantly restrict the application of natural products in dermal drug delivery.Fortunately,advancements in nanotechnology offer promising solutions to overcome these challenges.Different skin diseases and treatments require the precise delivery of natural active ingredients to specific skin layers,and the unique structure of nanocarriers enables targeted delivery to achieve desired therapeutic outcomes.This paper begins by exploring the pathogenesis and therapeutic targets of common skin conditions,including atopic dermatitis(AD),psoriasis,decubitus ulcers,diabetic foot ulcers(DFUs),as well as applications in antioxidant therapies and anti-aging strategies.Furthermore,it provides a detailed overview of the depths and locations within the skin where active compounds must be delivered to exert their effects effectively.Subsequently,this review categorizes and examines natural products based on their therapeutic effects on various skin diseases.It then highlights the skin depths and specific sites that can be targeted by different delivery systems designed to enhance skin permeability,tailored to meet the needs of skin disease treatment or care.By addressing these aspects,this review aims to provide a valuable reference for advancing research on nano-delivery systems in the field of topical skin drug delivery for the treatment and management of skin diseases. 展开更多
关键词 Nano-delivery systems Natural products Topical skin drug delivery Skin diseases Skin care and beauty
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“Connect”or“drag”?The impact of physiologically relevant inorganic ion pairs on the protein corona adsorption onto liposomes 认领 引用
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作者 Yeqi Huang Yue Gao +8 位作者 Yuxin Lin Yihao Li Si Xiong Xia Guo Chuanbin Wu Xin Pan Wenhao Wang Ziyu Zhao Zhengwei Huang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期314-318,共5页
The protein corona formation has been reported to influence the liposomes’behavioral performance in vivo.Accordingly,the effect of physiologically relevant inorganic ion pairs(sodium chloride,sodium sulfate,magnesium... The protein corona formation has been reported to influence the liposomes’behavioral performance in vivo.Accordingly,the effect of physiologically relevant inorganic ion pairs(sodium chloride,sodium sulfate,magnesium chloride,and magnesium sulfate)was investigated.Bovine serum albumin(BSA)was selected as the model protein.Parameters including particle size and zeta potential were assessed,while various spectroscopic techniques were utilized to elucidate the changes in BSA during its interaction with liposomes.The particle size and light intensity distribution changes indicated that the introduction of inorganic pairs,especially the metal cations,could significantly influence both the adsorption of BSA and the aggregation of particles.Furthermore,spectral characterization elucidated that BSA exhibited more extended peptide chains with enhanced exposure to hydrophobic acid amino residues upon adding ion pairs.Electrostatic adsorption and chelation insertion were proposed as metal ion binding modes and the corresponding BSA corona formation.In the electrostatic adsorption mode,sodium ions can enhance the electrostatic interactions,facilitating the“connection”between BSA and liposomes.Magnesium ions can induce stronger hydrophobic interactions through chelation,effectively“drag”BSA segments into the lipid bilayer.This work highlighted important physiological factors for protein-liposome interaction and provided rational model constructions to lay the foundation for further relevant studies. 展开更多
关键词 Protein corona Liposomes Inorganic ion Interaction patterns Nanoparticle adsorption profile
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Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes 认领 引用
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作者 Ying Sun Kai Yan +8 位作者 Yi Zhang Yan-Qi Han Long-Hui Hao Yue Gao Hong-Liang Wang Hong-Qian Chu Jun Ye Yu-Ling Liu Yan-Fang Yang 《Military Medical Research》 SCIE CAS CSCD 2026年第7期1123-1170,共48页
Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influenci... Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influencing the progression of various non-metabolic diseases such as kidney diseases,cancer,neurodegenerative disorders,aging,and bone-related diseases.The metabolic pathways involved in lipid metabolism are complex and highly interconnected.Although the abundance of metabolic targets presents opportunities for lipid metabolism regulation,the limited precision and safety of traditional therapeutic approaches remain significant challenges.These limitations have catalyzed the development of multifunctional nano-delivery platforms aimed at targeted intervention in lipid metabolic processes,further enhancing the flexibility of lipid metabolism regulation.This review outlines the latest advancements and representative applications of these multifunctional nano-delivery platforms.Notably,extensive research has been conducted on nanoparticles and liposomes,with these technologies being relatively mature.Furthermore,numerous novel biomaterials,including engineered adipocytes,exosome vesicles secreted by natural cells,smart-responsive nanomicelles,composite hydrogels,and engineered lipid droplets,are being increasingly explored.Finally,the review discusses the advantages of drug delivery strategies based on the targeted intervention of lipid metabolic processes,the limitations of current technologies,promising future research directions,and treatment challenges. 展开更多
关键词 Multifunctional nano-delivery system Lipid metabolism Lipid metabolism reprogramming Lipid metabolism-related diseases
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Exploration of Integrated Theory and Practical Teaching Mode for Chemical Engineering Principles under the Emerging Engineering Background 认领 引用
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作者 Yue Gao Xuan Qi +1 位作者 Zhifeng Yang Ying Gao 《Journal of Contemporary Educational Research》 2026年第7期204-210,共7页
The construction of emerging engineering disciplines focuses on industrial transformation and upgrading as well as talent demands in emerging chemical sectors, putting forward innovation requirements for the tradition... The construction of emerging engineering disciplines focuses on industrial transformation and upgrading as well as talent demands in emerging chemical sectors, putting forward innovation requirements for the traditional classroom teaching of Chemical Engineering Principles. As a core course linking basic theories and engineering applications for chemical majors, it is confronted with prevalent practical difficulties including abstract theoretical formulas, disconnection between classroom lectures and industrial realities, and separation of theoretical learning from practical application. Based on the talent cultivation objectives of emerging engineering education, this paper takes integrating theoretical knowledge into the classroom and connecting classroom teaching with engineering scenes as the core idea, and constructs a new integrated teaching mode from four dimensions: reconstruction of teaching content, innovation of classroom teaching methods, integrated design of theory and practice, and diversified assessment mechanisms. Classroom practice is carried out around typical unit operations such as fluid transportation, heat transfer, and distillation. Practical results show that the integrated classroom can reduce students’ difficulty in understanding theories and strengthen their engineering thinking, meeting the employment standards of emerging engineering industries including the new energy chemical industry and the green chemical industry. It can provide references for classroom reform of similar engineering majors. 展开更多
关键词 Emerging engineering Chemical Engineering Principles Classroom teaching Integration of theory and practice Teaching mode
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Analysis of Fracture Failure of Connecting Bolts for Diaphragm Pump Valve Box Cover 认领 引用
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作者 Xuan Qi Yue Gao 《Journal of Electronic Research and Application》 2026年第3期122-129,共8页
Aiming to address the repeated fracture of connecting bolts in the feed valve box cover of a large Type A diaphragm pump,a three-dimensional model of the valve box assembly was first established.Subsequently,bolt stre... Aiming to address the repeated fracture of connecting bolts in the feed valve box cover of a large Type A diaphragm pump,a three-dimensional model of the valve box assembly was first established.Subsequently,bolt strength was evaluated using three finite element analysis methods:axisymmetric analysis,cyclic symmetry analysis,and full 3D integral analysis.It was clarified that the first few threads bear the maximum stress,which is consistent with the actual fracture position.Combined with the analysis results,it is concluded that the main causes of bolt fracture are alternating load bearing,low safety margin of specifications,and the coarse thread design also affects its load-bearing capacity. 展开更多
关键词 Diaphragm pump Valve box cover bolt Fracture analysis Finite element analysis Alternating load
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新工科背景下计算机网络实验教学体系重构与实践 认领 引用
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作者 高悦 马小科 +2 位作者 赵双睿 程珂 权义宁 《计算机教育》 2026年第7期85-90,共6页
针对传统的计算机网络实验教学体系已无法满足现代社会对工程技术人才的需求,分析新工科对计算机实验教学的要求,提出基于新工科理念的计算机网络实验教学体系重构与实践方案,从模块化划分实验内容、采用应用驱动的教学方法、运用支架... 针对传统的计算机网络实验教学体系已无法满足现代社会对工程技术人才的需求,分析新工科对计算机实验教学的要求,提出基于新工科理念的计算机网络实验教学体系重构与实践方案,从模块化划分实验内容、采用应用驱动的教学方法、运用支架式教学法引导学生自主探索、建立多元化的评价体系以及引入人工智能大模型辅助教学方面,详细阐述计算机网络实验教学体系的设计与实践,最后说明教学实践效果。 展开更多
关键词 新工科 计算机网络 实验教学体系 模块化设计 支架式教学法 多元化评价 人工智能
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Breaking boundaries in O3-type NaNi1/3Fe1/3Mn1/3O2cathode materials for sodium-ion batteries:An industrially scalable reheating strategy for superior electrochemical performance 认领 引用 被引量：2
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作者 Manman Chen Cai Zhao +10 位作者 Yan Li Hui Wang Kaihang Wang Shengchen Yang Yue Gao Wenjuan Zhang Chun Chen Tao Zhang Lei Wen Kehua Dai Jing Mao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第3期107-119,共13页
To address the challenges of air stability and slurry processability in layered transition metal oxide O3-type NaNi1/3Fe1/3Mn1/3O2(NFM)for sodium-ion batteries(SIBs),we have designed an innovative 500℃... To address the challenges of air stability and slurry processability in layered transition metal oxide O3-type NaNi1/3Fe1/3Mn1/3O2(NFM)for sodium-ion batteries(SIBs),we have designed an innovative 500℃reheating strategy.This method improves the surface properties of NFM without the need for additional coating layers,making it more efficient and suitable for large-scale applications.Pristine NFM(NFM-P)was first synthesized through a high-temperature solid-state method and then modified using this reheating approach(NFM-HT).This strategy significantly enhances air stability and electrochemical performance,yielding an initial discharge specific capacity of 151.46 mAh/g at 0.1C,with a remarkable capacity retention of 95.04%after 100 cycles at 0.5C.Additionally,a 1.7 Ah NFM‖HC(hard carbon)pouch cell demonstrates excellent long-term cycling stability(94.64%retention after 500 cycles at 1C),superior rate capability(86.48%retention at 9C),and strong low-temperature performance(77%retention at-25℃,continuing power supply at-40℃).Notably,even when overcharged to 8.29 V,the pouch cell remained safe without combustion or explosion.This reheating strategy,which eliminates the need for a coating layer,offers a simpler,more scalable solution for industrial production while maintaining outstanding electrochemical performance.These results pave the way for broader commercial adoption of NFM materials. 展开更多
关键词 Sodium-ion batteries O3-type layered oxide cathode Reheating Al2O3coating Pouch full cells
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Endocrine-disrupting chemicals in human adipose tissue and associations between exposure and obesity 认领 引用
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作者 Zhenhua Lu Aijing Li +5 位作者 Yue Gao Haowei Shi Xiaolei Shi Weijing Li Jinghai Song Maoyong Song 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第9期552-561,共10页
Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China a... Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity. 展开更多
关键词 Endocrine-disrupting chemicals Mixed exposure Visceral adipose tissue Body-mass index Obesity
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Polymeric micelles:“magic bullets”for cancer treatment 认领 引用
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作者 Yue Gao Meihong Zhang +6 位作者 Qian Chen Yuxin Lin Chuanbin Wu Xin Pan Ling Guo Tze Ning Hiew Zhengwei Huang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2025年第6期1103-1125,I0046-I0076,共23页
Nanocarriers are an efficient drug delivery tool used for cancer treatment.Among various nanocarriers,polymeric micelles(PMs)have garnered attention in recent years due to their excellent properties,including improved... Nanocarriers are an efficient drug delivery tool used for cancer treatment.Among various nanocarriers,polymeric micelles(PMs)have garnered attention in recent years due to their excellent properties,including improved solubility of insoluble drugs,enhanced targeting and accumulation of drugs at the cancer site,increased sensitivity of cancer cells to chemotherapeutic drugs,and prolonged circulation time.This review summarizes the preparation methods,characterization,advantages,and classification of PMs as drug delivery systems for oncology therapeutics.In particular,the self-assembly mechanisms of active ingredients into PMs,the anticancer activities of PMs associated with various cell death pathways,and the research cases of PMs as drug delivery vehicles in cancer therapy are described.Finally,this review summarizes the status of the clinical trials and real-world applications of PMs and briefly analyzes the reasons for the unsatisfactory commercialized states.This review supports further research on the role of PMs as nanocarriers in cancer therapy and adds insights for the successful clinical translation of PM-based products. 展开更多
关键词 Cancer therapy Polymeric micelles Drug delivery systems Cell death pathways Clinical application
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Spatial continuity and stress transfer:Primary and complementary factors shaping pure-swarm laboratory catalog into mixed burst-like and swarm-like 认领 引用
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作者 Qiquan Xiong Qing Lin +1 位作者 Yue Gao Jesse C.Hampton 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2025年第1期55-70,共16页
Natural earthquakes and micro-seismicity resulting from hydraulic fracturing or other engineering practices display distinctively different spatial-temporal features,like mixed burst-and swarm-like features or predomi... Natural earthquakes and micro-seismicity resulting from hydraulic fracturing or other engineering practices display distinctively different spatial-temporal features,like mixed burst-and swarm-like features or predominantly swarm-like features.The mechanism(s)contributing to such observations can be diverse.We present the inspections on the dynamic formation process of the single swarm-like tree in laboratory acoustic emission(AE)catalogs.Such largest swarm-like trees can contain>97%AE events from the entire catalog within a test;and all catalogs under investigation display scale-invariance features.The formation of the largest swarm-like tree correlates with the rock fracture process analogue of the source pervasive process,where its AE releases exhibit significant spatial well-organization.Comparison to other laboratory catalogs under different laboratory settings helps us identify the spatial continuity of the rock fracture process as the primary factor in forming the largest swarm-like trees at laboratory scale.The stress transfer process is involved in the rock fracture process for the tests having pre-existing spatial discontinuity.Artificial perturbations on the spatial information induced by the stress transfer process further confirm that stress transfer also serves to shift the pure swarm-like catalog into a mixed burst-and swarm-like catalog.These laboratory observations may provide inspirational insights for understanding the field-scale mechanism(s)shaping the spatial-temporal energy release features. 展开更多
关键词 Rock fracture Laboratory catalogs Swarm-like events Acoustic emission(AE) Scale-invariance
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Microstructures, Quartz Fabrics, Flow Vorticity Analyses and Zircon U-Pb Ages of the Tuerhongshate Ductile Shear Zone, Eastern Irtysh Tectonic Belt, Southern Chinese Altai Orogen, and Tectonic Implications 认领 引用
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作者 Yue Gao Laixi Tong +2 位作者 Zhao Liu Chao Li Jinhai Luo 《Journal of Earth Science》 SCIE CAS CSCD 2025年第6期2411-2425,共15页
The Irtysh tectonic belt lies on the southern margin of the Chinese Altai Orogen. Several secondary shear zones with NW-SE strikes have developed in this tectonic belt, and the deformation processes are of great signi... The Irtysh tectonic belt lies on the southern margin of the Chinese Altai Orogen. Several secondary shear zones with NW-SE strikes have developed in this tectonic belt, and the deformation processes are of great significance to understanding the tectonic regime of the Altai Orogen in the Late Paleozoic. The Tuerhongshate ductile shear zone is located in the eastern Irtysh tectonic belt with obvious deformed structures. The felsic rocks are strongly mylonitized, exhibiting S-C fabrics, asymmetric rotational porphyroclasts, and bookshelf structures of the plagioclases, indicating a sinistral shear sense. The deformation mechanisms, lattice preferred orientations (LPOs) of quartz, and opening angles of quartz c-axis suggest that the deformation temperatures range from 400 to 500 ℃, consistent with higher-greenschist to lower-amphibolite facies conditions. The calculated kinematic vorticity values (Wk) of the studied samples range from 0.53 to 0.89 and indicate general shear to simple shear, based on rotational rigid porphyroclast method and oblique grain-shaped/quartz c-axis fabric method. The U-Pb ages of magmatic zircons in felsic mylonites indicate that the sinistral shear occurred after 296.7 ± 3.0 Ma (Early Permian) in the Tuerhongshate shear zone and persisted for approximately 13 Ma. Combined with the tectonic setting and the observed sinistral strike-slip shear indicators in the mylonite zone, these features demonstrate that the Irtysh tectonic belt was in a post-orogenic and strike-slip environment following the closure of the Irtysh Ocean. 展开更多
关键词 Irtysh tectonic belt sinistral shear microstructures quartz c-axis fabrics flow vorticity post-orogenic rheology tectonics
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Manipulating TWIP/TRIP via oxygen-doping to synergistically enhance strength and ductility of metastable beta titanium alloys 认领 引用
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作者 Yue Gao Wenlong Xiao +6 位作者 Damon Kent Junshuai Wang Wentao Jiang Fanqiang Meng Ziling Peng Yu Fu Chaoli Ma 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第12期58-70,共13页
Metastable β-Ti alloys exhibiting twinning-induced plasticity (TWIP) and transformation-induced plasticity (TRIP) generally have excellent ductility, but typically at the expense of relatively low yield strengths whi... Metastable β-Ti alloys exhibiting twinning-induced plasticity (TWIP) and transformation-induced plasticity (TRIP) generally have excellent ductility, but typically at the expense of relatively low yield strengths which has restricted their widespread use. Our work shows that interstitial oxygen can be employed to regulate β phase stability to significantly enhance both strength and ductility of TWIP/TRIP alloys. For a Ti-32Nb wt.% base alloy, inclusion of 0.3 wt.% O enhanced ductility by more than 140 %, reaching up to 54 % strain, and improved the tensile yield strength by over 95 % to 632 MPa. Compared to other common engineering alloys such as Ti-45Nb, elongation was increased by 29 %, and the yield strength increased by 182 MPa, respectively. Here, we elucidate on impacts of oxygen doping on TWIP/TRIP behaviors in the Ti-32Nb alloy. We reveal that oxygen regulates the critical stress for martensitic transformation, twinning, and dislocation slip. At lower oxygen doping concentrations (≤0.3 wt.% O), multi-stage martensitic transformation and martensitic twinning resulted in high ductility. In higher oxygen content alloys (≥0.5 wt.% O), deformation occurred initially via twinning, while strain induced martensite was subsequently induced in retained β phase regions. Oxygen concentrations control the deformation mechanisms, providing a flexible means to synergistically balance an alloy's strength and ductility. The use of oxygen to enhance stability of the β phase and regulate deformation behaviors is a promising new approach for creating high-performance TWIP/TRIP metastable β-Ti alloys with outstanding mechanical properties. 展开更多
关键词 Titanium alloy TWIP/TRIP Oxygen-doping Deformation behavior Critical stress High-energy X-ray diffraction
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