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Experimental techniques for qualitative and quantitative characterization of shale oil reservoir space,minerals,and fluids 认领 引用 被引量：1
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作者 Siyu Chen Zhenkai Huang +6 位作者 Guangyou Zhu Xi Li Zhiyong Chen Ruilin Wang Yue Huang Shengnan Liu Bijun Huang 《Energy Geoscience》 EI CAS CSCD 2026年第2期1-16,共16页
Characterizing shale oil reservoirs encompassing pore space,mineralogy,and fluids is fundamental to effective exploration and development.Recent advances in experimental techniques have significantly improved both the... Characterizing shale oil reservoirs encompassing pore space,mineralogy,and fluids is fundamental to effective exploration and development.Recent advances in experimental techniques have significantly improved both the qualitative and quantitative analysis of these components;however,a comprehensive systematic review is lacking.High-resolution imaging technologies,such as Scanning Electron Microscopy(SEM),Field Emission Scanning Electron Microscopy(FE-SEM),and Focused Ion Beam Scanning Electron Microscopy(FIB-SEM),enable detailed visualization of pore structures.Gas adsorption and high-pressure mercury intrusion methods provide accurate pore-scale quantification.Moreover,techniques like X-ray Diffraction(XRD),X-ray Fluorescence Spectroscopy(XRF),and Electron Probe Microanalysis(EPMA)allow precise mineral identification and compositional analysis.Confocal Scanning Laser Microscopy(CSLM),Raman Spectroscopy,Nuclear Magnetic Resonance(NMR),and Rock Pyrolysis provide insights into fluid occurrence and content within shale reservoirs.Based on a comprehensive review of existing research,this study identifies several key future directions:(1)addressing the challenges of nanopore observation in reservoir space characterization while minimizing the impact of sample preparation on pore structure;(2)improving the accuracy of quantitative mineral analysis and developing advanced new technologies for the precise measurement of complex mineral compositions;(3)enhancing the fluid quantitative evaluation of fluids by more effectively restoring subsurface geological conditions.This paper presents a current synthesis and forward-looking perspective on experimental techniques supporting shale oil exploration,aiming to guide future research and technological innovation in this field. 展开更多
关键词 Experimental technique Shale oil Reservoir space Mineral analysis Fluid characterization Qualitative and quantitative analysis
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In-flight Trigger Classification Algorithm for GECAM-C 认领 引用
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作者 Jia-Ciong Liu Shao-Lin Xiong +26 位作者 Yue Huang Xiao-Yun Zhao Chen-Wei Wang Xiang-Yang Wen Chao Zheng Wang-Chen Xue Yan-Qiu Zhang Wen-Jun Tan Yue Wang Jin-Peng Zhang Hao-Xuan Guo Yang-Zhao Ren Sheng-Lun Xie Peng Zhang Zheng-Hua An Ke Gong Xiao-Bo Li Xin-Qiao Li Ya-Qing Liu Xiao-Jing Liu Xiang Ma Rui Qiao Jin Wang Ping Wang Sheng Yang Da-Li Zhang Shi-Jie Zheng 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2026年第4期221-227,共7页
As a member of the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)constellation,GECAM-C is an all-sky gamma-ray monitor with in-flight trigger capability aboard the SATech-01 experime... As a member of the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)constellation,GECAM-C is an all-sky gamma-ray monitor with in-flight trigger capability aboard the SATech-01 experimental satellite.Operating in a Sun-Synchronous Orbit,GECAM-C generates many in-flight triggers,some of which correspond to important astrophysical bursts,such as gamma-ray bursts and soft gamma-ray repeaters,which may require follow-up observations.However,there are also a substantial number of non-astrophysical triggers,such as particle events.Therefore,a prompt and accurate classification of in-flight triggers is essential for scientific research.In this work,we propose an automatic trigger classification algorithm for GECAM-C in-flight triggers with Bayesian inference.Applying this method to GECAM-C triggers from 2022 December to 2023 December,we demonstrate that it can successfully categorize all trigger types with an accuracy of about 95%,thereby providing effective support for rapid follow-up observations. 展开更多
关键词 instrumentation detectors-methods statistical-methods data analysis
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Experimental study on combustion stability and performance of rocket ejector-ramjet engine 认领 引用
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作者 Hedong LIU Yuqian CHEN +1 位作者 Yue HUANG Yancheng YOU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第3期357-369,共13页
The rocket ejector has great potential for bridging the thrust gap between the turbine and ramjet modes of the Turbine-Based Combined Cycle(TBCC) engine.In this work,a rocket ejector was proposed and used in the Eject... The rocket ejector has great potential for bridging the thrust gap between the turbine and ramjet modes of the Turbine-Based Combined Cycle(TBCC) engine.In this work,a rocket ejector was proposed and used in the Ejector-Ramjet(ERJ) engine model.Furthermore,the thrust and thermal-fatigue performances of the rocket ejector are investigated through the thrust bench tests.The combustion stability and performance of ERJ engine are studied by the ground direct-connect experiments under different conditions.Experimental results suggest that the rocket ejector can realize a wide range of thrust variation from 510 N to 1 100 N and a specific impulse of more than250 s,whereas accompanying with a short lifespan about 4 s.As expected,the rocket ejector can significantly expand the flight envelope of the ERJ engine downward to Mach number Ma∞=2.0 and altitude H = 13 km.Nevertheless,when Ma∞is less than or equal to 3.0,the ramjet combustor is unable individually operated and that need to be improved for engineering application.The lower oxygen/kerosene ratio of rocket ejector and the equalized injection-forward and injection-center of ramjet fuel are beneficial for enhancing the combustion stability and thrust performance of ERJ engine.Overall,experiments primarily validated that the rocket ejector has the advantages of facilitating ignition and flame stabilization,improving the working environment of the ERJ engine,and expanding the operating range.But the remarkable thing is that both the ejector and ramjet combustor can be greatly improved for optimizing the performance of ERJ engine further. 展开更多
关键词 Rocket ejector Thrust Ejector-ramjet Combustion performance Direct-connect experiment
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Comparison of three-dimensional surgical system versus binocular microscope for implantable Collamer lens implantation:a randomized clinical trial 认领 引用
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作者 An-Ran Xuan Wei Liu +5 位作者 Ya-Ning Zhang Chen Zhang Rui-Bo Yang Yue Huang Hui Liu Shao-Zhen Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第8期1526-1532,共7页
●AIM:To compare the efficacy,safety,visual outcomes,satisfaction,and comfort of three-dimensional(3D)heads-up visualization system-assisted and conventional microscopic implantable Collamer lens(ICL)surgery.●METHODS... ●AIM:To compare the efficacy,safety,visual outcomes,satisfaction,and comfort of three-dimensional(3D)heads-up visualization system-assisted and conventional microscopic implantable Collamer lens(ICL)surgery.●METHODS:Patients undergoing ICL or Toric ICL(TICL)implantation were enrolled and randomized into two groups:TM group(under a conventional microscope)and 3DM group(under NGENUITY 3D visualization system).Ocular parameters were assessed preoperatively and at 1wk,1,3,and 6mo postoperatively.The duration of key surgical steps and the incidence of complications were recorded.Patient-reported outcomes(dry eye,visual quality,comfort)and surgeon satisfaction were assessed using standardized questionnaires.●RESULTS:The study included 98 eyes of 98 refractive error patients(17 males),50 eyes in TM group(age 27.74±5.65y),and 48 eyes in 3DM group(age 29.20±4.89y).Efficacy,safety,quality of vision(QoV),dry eye symptoms,and patients’satisfaction at 6mo were not significant across the time points of 1wk,1,3 and 6mo.No complication was observed in either group.The 3DM group was associated with a longer main step operation time(P=0.037)but better patient visual comfort(P<0.001).The difference in surgical fluency was not statistically significant(P=0.067).Notably,surgeons reported no delays or discomfort and rated the 3DM system significantly higher in image resolution,range of view,depth perception,color contrast,and postural comfort(all P<0.001).●CONCLUSION:For ICL surgery,the use of the NGENUITY 3D visualization system achieves comparable surgical efficacy,safety,and patient satisfaction to procedures performed under a traditional microscope,while delivering superior intraoperative visual performance and postural comfort for the surgeon.These ergonomic and visual advantages make it a promising tool for enhancing clinical practice and surgical training. 展开更多
关键词 three-dimensional surgical visualization system implantable Collamer lens V4c myopia visual outcome
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Reassessing the phylogenetic relationships of Pseudosorghum and Saccharinae(Poaceae)using plastome and nuclear ribosomal sequences 认领 引用 被引量：2
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作者 Kai Chen Yan-Chun Liu +5 位作者 Yue Huang Xu-Kun Wu Hai-Ying Ma Hua Peng De-Zhu Li Peng-Fei Ma 《Plant Diversity》 SCIE CAS CSCD 2025年第3期382-393,共12页
The sugarcane subtribe Saccharinae(Andropogoneae,Poaceae)was established in 1846,but its delimitation has long been debated.Moreover,the relationships among the genera of Saccharinae remain unclear,and there is no con... The sugarcane subtribe Saccharinae(Andropogoneae,Poaceae)was established in 1846,but its delimitation has long been debated.Moreover,the relationships among the genera of Saccharinae remain unclear,and there is no consensus on whether Pseudosorghum,a small genus in tropical Asia with only two species,should be included.Here,we performed phylogenomic analyses using whole plastomes(69 of them newly sequenced)from 132 individuals,representing 65 species in 19 related genera.We also built trees with nuclear ribosomal DNA sequences.Our results justify the inclusion of Pseudosorghum,likely also the Eulalia Clade III,in Saccharinae.Furthermore,both morphological and molecular analyses support merging the two Pseudosorghum species.The backbone relationships of the Saccharinae phylogeny were highly supported with four polyphyletic clades of Miscanthus and the inclusion of Narenga and Tripidium rufipilum in Saccharum.Pseudosorghum is moderately supported as sister to the Miscanthus Clade I,while the remaining Tripidium species could be excluded from the subtribe.Saccharinae is estimated to have originated~3.73 million years ago in East Asia,followed by intercontinental dispersals.Our study provides a comprehensive phylogenetic framework for future taxonomic revisions of this economically important subtribe. 展开更多
关键词 Phylogenomics Saccharinae Pseudosorghum Plastome nrDNA Biogeography
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Transcriptome analysis reveals the common and specific pathways of citric acid accumulation in different citrus species 认领 引用 被引量：2
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作者 Jiaxian He Juan Sun +5 位作者 Yue Huang Lun Wang Shengjun Liu Zhenghua Jiang Xia Wang Qiang Xu 《Horticultural Plant Journal》 SCIE CAS CSCD 2025年第2期520-534,共15页
Citric acid is an important contributor to fruit flavor.The extremely significant differences in citric acid levels are observed among citrus species and varieties.The molecular basis of citric acid accumulation remai... Citric acid is an important contributor to fruit flavor.The extremely significant differences in citric acid levels are observed among citrus species and varieties.The molecular basis of citric acid accumulation remains largely unknown on the inter-species level.Here,we performed transcriptome analysis of five pairs of acidic and acidless variety fruits from kumquat(Citrus crassifolia),lemon(C.limon),pummelo(C.maxima),mandarin(C.reticulata),and sweet orange(C.sinensis)to investigate the common and specific genes related to citric acid accumulation in these citrus species.Transcript profiles of the citrate metabolism genes revealed that the mechanism of citric acid accumulation in kumquat differed from that in the other four species.The comparative analysis and weighted gene co-expression network analysis identified 61 candidate genes from lemon,pummelo,mandarin,and sweet orange.Vacuolar acidification regulated by CitPH4-CitAN1-CitPH5was a common mechanism underlying citric acid accumulation in these four species.In addition,gene network analysis indicated that CitPH4 was a central regulator,exhibiting a strong correlation with the genes involved in vacuolar trafficking and potassium(K+)transport.The co-expression and functional enrichment analyses showed that active sugar metabolism and increased citrate synthesis were mainly responsible for the accumulation of citric acid in kumquat.Twenty-four transcription factors were identified as candidate regulators,of which CitbHLH28 was found to regulate acidity level via transactivating CWINV2 and PK3 expressions.Overall,this study provides an insight into the mechanism of citric acid accumulation in citrus fruit and provides useful references for fruit quality improvement through acidity control in different citrus species. 展开更多
关键词 Citrus Citric acid Transcriptome Regulatory network Vacuolar acidification Citrate synthesis
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Genomic origin of Citrus reticulata“Unshiu” 认领 引用 被引量：1
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作者 Shengjun Liu Luoyun Wang +11 位作者 Xiang Zhang Lifang Sun Fuzhi Ke Yue Huang Lizhi Song Haiping Ye Jianguo Xu Yuantao Xu Xia Wang Xiuxin Deng Gaoping Liu Qiang Xu 《Horticulture Research》 SCIE CSCD 2025年第5期24-32,共9页
Satsuma mandarin(Citrus reticulata“Unshiu”)is a global cultivar with superior fruit characteristics and ranking among the top citrus cultivars in terms of production.It is also a key contributor to citrus breeding.H... Satsuma mandarin(Citrus reticulata“Unshiu”)is a global cultivar with superior fruit characteristics and ranking among the top citrus cultivars in terms of production.It is also a key contributor to citrus breeding.However,the lack of high-quality genome makes the origin of Satsuma mandarin has long been a matter of debate.Here,we assembled a gap-free,high-quality genome of Satsuma mandarin.Meanwhile,we collected and sequenced 15 indigenous citrus varieties in Zhejiang Province,12 Satsuma mandarins,21 citrus hybrids related to Satsuma mandarin,10 modern citrus varieties,and 7 other mandarins.Through high-resolution genome analysis,we inferred that Satsuma mandarin originated from a cross between C.reticulata“Ruju”×C.reticulata“Bendiguang”and proposed that Satsuma mandarin most probably originated in East area in Zhejiang Province of China,where the two parents-like cultivars are still found in a sympatric region to date.These results provide new insights into the origin model of Satsuma mandarin.The spread of mandarin is also discussed,which probably associated with the culture exchange and trade activities between Japan and China from Tang Dynasty and afterwards. 展开更多
关键词 satsuma mandarin citrus genomic analysis citrus h citrus reticulata satsuma mandarinmeanwhilewe satsuma mandarins origin
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Biodegradable phosphorus-modified Mg2Ge/Mg-Cu composite with good angiogenic,osteogenic,and antibacterial functionalities for bone-fixation applications 认领 引用
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作者 Xian Tong Lanxin Gu +7 位作者 Jianchen Yu Yue Han Yue Huang Xinkun Shen Yuncang Li Jixing Lin Cuie Wen Daoyi Miao 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2025年第9期4628-4648,共21页
Magnesium(Mg)-based composites are expected to be useful for biodegradable bone-implant materials due to their degradability,similar elastic modulus to that of bone,and biofunctionalities.However,their rapid degradati... Magnesium(Mg)-based composites are expected to be useful for biodegradable bone-implant materials due to their degradability,similar elastic modulus to that of bone,and biofunctionalities.However,their rapid degradation,poor biotribology performance,and lack of vascularization and antibacterial activity are not conducive to bone-fixation applications.In this study,an in situ Mg2Ge/Mg-Cu-P composite with a nominal composition of Mg-10Ge-2Cu-0.5P(denoted MGCP)was prepared via phosphorus(P)-modified casting followed by hot extrusion for biodegradable bone-fixation applications.For comparison,an in situ Mg2Ge/Mg-Cu composite(Mg-10Ge-2Cu,denoted MGC)was prepared under the same conditions without P-modification.The hot-extruded(HE)MGCP sample showed significantly improved corrosion resistance with corrosion rates of 2.2 mm/y and 2.51 mm/y as measured by potentiodynamic-polarization and hydrogen-release testing in Dulbecco’s Modified Eagle Medium supplemented with fetal bovine serum(denoted DMEM).The HE MGCP also exhibited notably enhanced mechanical properties and biotribological resistance in DMEM,with an σUTS of ~304.2 MPa,σTYS of ~202.5 MPa,elongation of ~12.3%,σUCS of 769.0 MPa,σCYS of 208.0 MPa,and Brinell hardness of 105.3 HB,along with smallerσTYS andσCYS decreases after 3 d of immersion in Hanks’solution.In comparison to pure titanium and Mg,the HE MGCP demonstrated much greater cytocompatibility,angiogenic capacity,and osteogenic differentiation and mineralization capability.Furthermore,the HE MGCP displayed markedly higher in vitro antibacterial activity,in vivo antibacterial and anti-inflammatory ability,and good biosafety in a rat subcutaneous-implantation model compared to pure titanium and Mg,indicating significant potential for biodegradable bone-fixation applications. 展开更多
关键词 Angiogenic ability Anti-inflammatory Biotribological performance Mechanical stability Mg2Ge/Mg-Cu composite
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Present-day temperature and pressure fields in key areas of Northeast China:Implications for unconventional resource evaluation 认领 引用
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作者 Yue Huang Jian Chang +1 位作者 Nansheng Qiu Nobuo Maeda 《Geoscience Frontiers》 SCIE CAS CSCD 2025年第6期137-155,共19页
The temperature-pressure fields within hydrocarbon-bearing basins are key geological factors controlling hydrocarbon generation,migration,and accumulation.In this study,we focus on the Qingshankou Formation in the nor... The temperature-pressure fields within hydrocarbon-bearing basins are key geological factors controlling hydrocarbon generation,migration,and accumulation.In this study,we focus on the Qingshankou Formation in the northern part of the central depression of the Songliao Basin,China.A multi-parameter weighted evaluation model was created using present temperature-pressure field character-istics,with formation temperature-pressure as core variables,to evaluate shale oil resource potential.In addition,we explored the control mechanisms of temperature-pressure evolution during geological history on shale oil accumulation and further assessed the applicability of the proposed method.Our results show that the geothermal gradient of the Qingshankou Formation decreases from Member1to Member 3(3.84 ℃/100 m,2.93 ℃/100 m,and 2.49 ℃/100 m,respectively).High-temperature zones are widely distributed in the Gulong sag,with the average temperature of the Gulong shale exceeding 95 ℃ and reaching an average of approximately 115 ℃.Overpressure in the Qingshankou Formation exhibits a west-high to east-low trend.The overpressure zones of the Gulong shale are mainly concen-trated in the Qijia-Gulong and Sanzhao sag,with average pressure coefficients of 1.52 and 1.36,respec-tively.The Opc model identified Class Ⅰ and Ⅱ favorable zones,mainly located in the central and southern parts of the Gulong Sag,as well as the central and southwestern Sanzhao Sag,with estimated shale oil resources of 7.1×108 tons and 17.2 ×108 tons,respectively.Evolutionary profiles from representative wells indicate that elevated temperatures enhance organic matter maturation and light oil generation,improving shale oil mobility,while overpressure suppresses hydrocarbon dissipation and provides a suf-ficient driving force for oil production.This study demonstrates that present-day temperature-pressure fields effectively reflect the evolution trends of paleo-thermal and pressure regimes.The proposed eval-uation method shows strong applicability and scalability,offering a new technical framework and theo-retical foundation for the exploration of unconventional hydrocarbon resources. 展开更多
关键词 Temperature-pressure field Gulong shale oil Resource prediction Resource evaluation The Qingshankou Formation Songliao Basin
Efficacy of 3%diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK 认领 引用 被引量：2
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作者 Jin-Jin Wang Ao-Miao Yu +5 位作者 Chang Liu Yue Huang Rui-Bo Yang Chen Zhang Hui Liu Shao-Zhen Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2025年第6期996-1002,共7页
AIM:To compare the efficacy of 3%diquafosol sodium(DQS)eye drops at different frequencies in dry eye(DE)after femtosecond laser-assisted in situ keratomileusis(FS-LASIK).METHODS:In this prospective study,DE patients a... AIM:To compare the efficacy of 3%diquafosol sodium(DQS)eye drops at different frequencies in dry eye(DE)after femtosecond laser-assisted in situ keratomileusis(FS-LASIK).METHODS:In this prospective study,DE patients after FS-LASIK were randomly divided into two groups.All patients were administered routine anti-inflammatory and anti-infective drugs after FS-LASIK.Additionally,both groups were treated with DQS,at frequencies of 4(DQS4 group)and 6(DQS6 group)times daily.Corneal fluorescein staining(CFS)score,non-invasive tear breakup time(NIBUT),tear meniscus height(TMH),lipid layer thickness(LLT),and incomplete blink rate(IBR)were assessed in patients preoperatively and at 1wk,1,and 3mo postoperatively.The Ocular Surface Disease Index(OSDI)questionnaire was also administered.RESULTS:Totally 119 patients(238 eyes)were randomly divided into the DQS4 group(60 individuals with 120 eyes)and DQS6 group(59 individuals with 118 eyes).From 1wk to 1mo after FS-LASIK,the CFS score in the DQS6 group decreased with statistical significance(P=0.014),while the DQS4 group showed an upward trend.Comparing with preoperative values,the NIBUT of both groups was significantly prolonged at various time points after FS-LASIK(P0.05),while the DQS6 group remained a little higher than preoperative values(P>0.05).The TMH levels in the DQS4 group increased significantly at 1wk postoperatively(P0.05).There was no significant difference in IBR and LLT between the two groups within 1mo postoperatively.At postoperative 3mo,the LLT in the DQS4 group was significantly higher than that in the DQS6 group(P<0.05).CONCLUSION:Within 1mo post-FS-LASIK,applying DQS six times daily is superior to four daily applications in improving CFS score,and in increasing NIBUT meanwhile.After 1mo,applying DQS four times daily also effectively alleviate DE symptoms and improve DE signs.Therefore,we recommend DE patients using DQS eye drops 6 times daily within 1mo after FS-LASIK,and maintaining it 4 times daily until 3mo postoperatively. 展开更多
关键词 diquafosol frequencies dry eye femtosecond laser-assisted in situ keratomileusis
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New insights on generalized heat conduction and thermoelastic coupling models 认领 引用 被引量：1
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作者 Yue HUANG Lei YAN +1 位作者 Hua WU Yajun YU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2025年第8期1533-1550,共18页
With the miniaturization of devices and the development of modern heating technologies,the generalization of heat conduction and thermoelastic coupling has become crucial,effectively emulating the thermodynamic behavi... With the miniaturization of devices and the development of modern heating technologies,the generalization of heat conduction and thermoelastic coupling has become crucial,effectively emulating the thermodynamic behavior of materials in ultrashort time scales.Theoretically,generalized heat conductive models are considered in this work.By analogy with mechanical viscoelastic models,this paper further enriches the heat conduction models and gives their one-dimensional physical expression.Numerically,the transient thermoelastic response of the slim strip material under thermal shock is investigated by applying the proposed models.First,the analytical solution in the Laplace domain is obtained by the Laplace transform.Then,the numerical results of the transient responses are obtained by the numerical inverse Laplace transform.Finally,the transient responses of different models are analyzed and compared,and the effects of material parameters are discussed.This work not only opens up new research perspectives on generalized heat conductive and thermoelastic coupling theories,but also is expected to be beneficial for the deeper understanding of the heat wave theory. 展开更多
关键词 generalized heat conduction thermoelastic coupling transient response generalized Cattaneo-Vernotte(CV)model generalized Green-Naghdi(GN)model
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Unraveling the characteristics of early esophageal neuroendocrine carcinoma using multi-model endoscopy:A retrospective study of serial cases 认领 引用
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作者 Tian Jin Yu-Wei Zhou +3 位作者 Pei-Sen Sun Yue Huang Jian-Guo Gao Xi Jin 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第11期129-140,共12页
BACKGROUND Early esophageal neuroendocrine carcinoma(E-NEC)is a rare but aggressive malignancy with poorly understood endoscopic features.Despite advancements in multi-model endoscopy,including white light endoscopy,m... BACKGROUND Early esophageal neuroendocrine carcinoma(E-NEC)is a rare but aggressive malignancy with poorly understood endoscopic features.Despite advancements in multi-model endoscopy,including white light endoscopy,magnifying end-oscopy narrow-band imaging(NBI),and endoscopic ultrasonography(EUS),the diagnostic characteristics of early E-NEC remain unclear.Comprehensive evalu-ation using these techniques can improve early detection and guide clinical management.This study aimed to investigate the endoscopic features of early E-NEC using multiple imaging modalities.We hypothesized that specific endos-copic patterns,such as irregular microvascular morphology or signs of submu-cosal invasion,could reliably distinguish early E-NEC from other esophageal lesions.AIM To characterize early E-NEC using multi-model endoscopy and identify diag-nostic endoscopic features.METHODS Clinical data of four patients with esophageal submucosal lesions identified by gastroscopy and pathologically diagnosed as E-NEC in the Department of Gastroenterology,The First Affiliated Hospital of Zhejiang University School of Medicine between January 2020 and August 2024 were retrospectively analyzed,and their manifestations under multi-model endoscopy were observed.Grayscale values of ultrasound images in three patients with E-NEC and eight with esophageal leiomyoma were calculated using Image J software and compared using the Mann-Whitney U test.Neuroendocrine neoplasms(NENs)are a rare heterogeneous group of epithelial tumors that originate from peptidergic neurons and neuroendocrine cells,and are characterized by neuroendocrine differentiation.NENs include well-differen-tiated neuroendocrine tumors(NETs),poorly differentiated neuroendocrine carcinomas(NECs),and mixed neuroen-docrine-non-NENs[1],which exhibit a wide range of biological behaviors,from indolent,slow-growing lesions to highly aggressive and metastatic malignancies[2].NENs have the capacity for whole-body distribution,with gastroenteropan-creatic NENs comprising approximately 60%-75%of cases,followed by those in the lungs and mediastinum[3].Eso-phageal NENs(E-NENs)are extremely rare,accounting for only approximately 1.6%of all NENs and occurring far less frequently than other gastrointestinal NENs[4].However,with advancements in early cancer screening and diagnostic techniques,the incidence of E-NENs has gradually increased in recent decades[5].Among E-NENs,<1%are well-differ-entiated NETs,with the vast majority being poorly differentiated small cell NECs[6,7].Nevertheless,esophageal NEC(E-NEC)accounts for only 0.05%-7.6%of all esophageal malignant tumors[8,9],and is characterized by aggressive behavior,rapid progression,and early metastasis.E-NEC primarily affects middle-aged and older individuals,with a higher prevalence in males[10].The tumor-node-metastasis staging system of E-NEC mirrors that of esophageal squamous cell carcinoma(ESCC)[11,12].Early E-NEC is defined as lesions limited to the mucosal or submucosal layer(stages T1a and T1b),with or without nodal metastasis.Clinically,we found that early E-NEC often presents with absent or non-specific symptoms,such as mild dysphagia or retrosternal discomfort,which are easily overlooked or mistaken for benign esophageal conditions such as leiomyoma.Conventional imaging and tumor markers frequently fail to detect early lesions,and endoscopic biopsy results may be inconclusive due to submucosal tumor growth and the overlying normal epithelium[13].As a result,E-NEC is frequently diagnosed at an advanced stage(31%-90%of cases)when regional lymph node or distant metastases have already occurred,contributing to its poor prognosis[2,13,14].Studies have reported a median survival of approximately 11 months and 5-year survival rate of<10%[14].Given these challenges,early detection using endoscopy is essential for improving patient outcomes. 展开更多
关键词 Esophagus Carcinoma Neuroendocrine Endoscopic ultrasonography Leiomyoma Narrow band imaging
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Effect of Thickness on the pH Responsiveness of Strong Polyelectrolyte Brushes 认领 引用
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作者 Guang-Tao Mei Yue Huang +1 位作者 Jian Zhang Guang-Ming Liu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第12期2185-2190,I0006,共6页
Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been re... Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been revealed in the past ten years,it is still unclear if the pH-responsive properties of SPBs are affected by the brush thickness.In this study,we employed the positively charged poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride(PMETAC)and negatively charged sodium poly(styrenesulfonate)(NaPSS)brushes as model systems to explore the effect of thickness on the pH-responsive properties of SPBs.The results demonstrate that the pH-responsive properties of SPBs manifest different dependences on the brush thickness.Specifically,for both PMETAC and NaPSS brushes,the pH-responsive hydration and stiffness are influenced by the thickness,and the pH-responsive wettability and adhesion are almost unaffected by the thickness.This work not only provides a clear understanding of the relationship between the brush thickness and the pH responsiveness of SPBs,but also offers a new method to control the pH-responsive properties of SPBs. 展开更多
关键词 Strong polyelectrolyte brushes pH responsiveness Brush thickness Counterion-mediated hydrogen bonding
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Reconfiguration of B-DNA structure induced by ethanol 认领 引用
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作者 Yue Huang Yipeng Chen +2 位作者 Jing Li Rongri Tan Huanhuan Qiu 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第8期83-90,共8页
Solution environment can influence the flexible structure of DNA under specific conditions,thereby affecting the stability of nucleic acids and ultimately impacting critical biological processes such as replication an... Solution environment can influence the flexible structure of DNA under specific conditions,thereby affecting the stability of nucleic acids and ultimately impacting critical biological processes such as replication and transcription.Intracellular solution environment is variable,and previous studies have demonstrated that it can enhance the stability of DNA structures under certain circumstances.In this work,molecular dynamics simulations were conducted on B-DNA(1ZEW,with a nucleotide sequence of CCTCTAGAGG)derived from human breast cancer cells(MDA-MB231)to explore the effects of ethanol solution on DNA configuration transformation at different temperatures and concentrations.The calculated results indicate that ethanol facilitates the transition of 1ZEW from B-DNA to A-DNA at lower temperature.Furthermore,it is observed that temperature affects DNA structure to some extent,thereby modifying the trend in DNA configuration transformation.At low temperatures,the ethanol can promote the transformation of B-DNA into A-DNA at higher concentrations.While at higher temperatures,the DNA could be in a state of thermal melting.These conclusions presented here can give valuable insights into how ethanol affects B-DNA configuration transformations. 展开更多
关键词 ethanol molecular dynamic simulation DNA configuration
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清华大学校园鸟类多样性特征与环境关联 认领 引用 被引量：2
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作者 曾子轩 杨锐 +1 位作者 黄越 陈路遥 《生物多样性》 CAS CSCD 北大核心 2025年第5期21-33,共13页
城市绿地是生物多样性保护的重要载体,大学校园作为城市建成区的缩影,对提升小微绿地质量与生物多样性保护有重要意义。然而,已有大学校园生物多样性研究缺乏连续的时间与空间信息,且未明确物种与绿地内部植被结构的关联,可能影响小微... 城市绿地是生物多样性保护的重要载体,大学校园作为城市建成区的缩影,对提升小微绿地质量与生物多样性保护有重要意义。然而,已有大学校园生物多样性研究缺乏连续的时间与空间信息,且未明确物种与绿地内部植被结构的关联,可能影响小微绿地内部结构质量的优化。本文以清华大学校园鸟类为研究对象,通过实地调查鸟类与植物群落,运用广义线性模型和冗余分析,探讨了大学校园的鸟类分布时空格局以及鸟类组成与绿地特征的关联。研究发现,鸟类在大学校园绿地内部呈现集中分布且存在季节差异。鸟类组成与木本食源植物丰富度、灌木均匀度、草本盖度、人工草地盖度、乔木盖度存在关联。其中木本食源植物丰富度与鸟类多度、丰富度及Shannon多样性指数呈正向关联,灌木均匀度与鸟类丰富度及Shannon多样性指数呈正向关联,乔木盖度和人工草地盖度仅同时分别小于等于37.5%与小于39.8%时与鸟类多度呈正向关联,而草本盖度则与鸟类丰富度及Shannon多样性指数呈负向关联。此外,不同居留型鸟类的生境选择存在差异,秋季的过境鸟分布仅关联于植被结构,留鸟和冬候鸟分布同时关联于绿地物理特征和植被结构。我们建议在遵循自然规律营造城市小微绿地时,应控制乔木盖度和人工草地盖度同时在约40%以下,提升木本食源植物丰富度和灌木均匀度,并增加自然草本植物覆盖和植被结构层次。本研究面向城市小微绿地提出定量与定性结合的近自然绿地营造建议,为落实《昆明-蒙特利尔全球生物多样性框架》和《中国生物多样性保护战略与行动计划(2023–2030年)》的城市蓝绿空间质量提升目标提供了科学依据。 展开更多
关键词 生物多样性 城市小微绿地 大学校园 植被结构 保护管理
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Analysis on Influencing Factors of QuEChERS Pretreatment Method for Pesticide Residues 认领 引用
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作者 Yue HUANG Bo LIU +4 位作者 Kexin SHI Huifang YAO Lei WANG Pingyang SHAN Haoshuang DONG 《Agricultural Biotechnology》 2025年第1期62-63,68,共2页
Pesticide residues are related to environmental pollution,food safety and other issues,and sample processing is a key link in the whole analysis and detection process.Therefore,it is of far-reaching significance to es... Pesticide residues are related to environmental pollution,food safety and other issues,and sample processing is a key link in the whole analysis and detection process.Therefore,it is of far-reaching significance to establish a reliable and safe pretreatment technique for pesticide detection.QuEChERS(quick,easy,cheap,effective,rugged and safe),as a pretreatment method for pesticide residue analysis,is widely used in the field of testing and analysis because of its characteristics of rapidity,simplicity,low cost and high efficiency.In this paper,the effects of material selection involving extractants,analyte protectants and purification agents and their ratio optimization in QuEChERS method on the improvement of pretreatment efficiency were analyzed,hoping to provide further technical reference for expanding the pretreatment technique. 展开更多
关键词 Pesticide residue QuEChERS Influencing factor
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Application of Phased Nursing Guidance Program in Early Rehabilitation Training for Patients after Minimally Invasive Spinal Surgery 认领 引用
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作者 Yu Ma Yue Huang +1 位作者 Jian Zhu Zhenjie Sun 《Journal of Clinical and Nursing Research》 2025年第12期380-386,共7页
Objective:To explore the application effect of a phased nursing guidance program in early rehabilitation training for patients after minimally invasive spinal surgery,providing references for clinical rehabilitation n... Objective:To explore the application effect of a phased nursing guidance program in early rehabilitation training for patients after minimally invasive spinal surgery,providing references for clinical rehabilitation nursing.Methods:A total of 148 patients who underwent minimally invasive spinal surgery in our hospital from July 2023 to June 2025 were selected as the study subjects.They were randomly divided into an observation group and a control group using a random number table method,with 74 cases in each group.The control group received conventional nursing guidance after minimally invasive spinal surgery,while the observation group implemented a phased nursing guidance program.The pain levels(VAS scores),spinal function(JOA scores),quality of life(SF-36 scores),rehabilitation training compliance,and complication rates of the two groups of patients at different postoperative time points were compared.Results:At 7,14,and 30 days postoperatively,the Visual Analogue Scale(VAS)scores in the observation group were significantly lower than those in the control group(all p<0.001).At 7,14,and 30 days postoperatively,the Japanese Orthopaedic Association(JOA)scores in the observation group were significantly higher than those in the control group(all p<0.0001).Moreover,the JOA scores in both groups gradually increased over time,with a more pronounced increase observed in the observation group.At 30 days postoperatively,the scores in all dimensions of the Short Form-36(SF-36)scale in the observation group were significantly higher than those in the control group(all p<0.001).The compliance rate with rehabilitation training in the observation group was 95.95%,significantly higher than the 82.43%in the control group(χ2=7.008,p<0.05).The complication rate in the observation group was 4.05%,significantly lower than the 14.86%in the control group(χ2=5.049,p<0.05).Conclusion:The phased nursing guidance program can effectively alleviate pain,improve spinal function and quality of life,enhance compliance with rehabilitation training,and reduce the incidence of complications in patients after minimally invasive spinal surgery,making it worthy of clinical promotion and application. 展开更多
关键词 Minimally invasive spinal surgery Phased nursing guidance Early rehabilitation training Pain management Spinal function
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The Impact of Robot-Assisted Training on Upper Limb Function in Elderly Stroke Patients 认领 引用
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作者 Wenting Jia Chengyuan Zhu +3 位作者 Hua Xu Chunhua Yuan Xin Zhuang Yue Huang 《Journal of Clinical and Nursing Research》 2025年第11期243-248,共6页
Objective:To investigate the effects of robot-assisted training on upper limb function in elderly stroke patients.Methods:Seventy elderly stroke patients treated in the Rehabilitation Medicine Department of Jiangsu Pr... Objective:To investigate the effects of robot-assisted training on upper limb function in elderly stroke patients.Methods:Seventy elderly stroke patients treated in the Rehabilitation Medicine Department of Jiangsu Provincial Organ Hospital from January 2023 to December 2023 were randomly divided into an intervention group(n=35)and a control group(n=35).In addition to conventional rehabilitation and nursing care,both groups received 40 minutes of daily upper limb training.The control group underwent entirely manual training,whereas the intervention group received a combination of 20 minutes of manual and 20 minutes of robot-assisted training.All participants completed this protocol five times weekly for four weeks,with assessments of upper limb motor function and activities of daily living(ADL)conducted pre-and post-intervention.Results:After treatment,both groups showed significant increases in Fugl-Meyer Assessment(FMA-UE)and Barthel Index(BI)scores compared to before treatment(p0.05).Conclusion:Robot-assisted training can improve upper limb motor function and enhance ADL capabilities in elderly stroke patients. 展开更多
关键词 Stroke Robot-assisted training Upper limb function
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Standardized Operational Protocol for Human Brain Banking in China 认领 引用 被引量：18
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作者 Wenying Qiu Hanlin Zhang +18 位作者 Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第2期270-276,共7页
With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseas... With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. 展开更多
关键词 Standardized Brain Banking increasing
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The high-quality genome of pummelo provides insights into the tissue-specific regulation of citric acid and anthocyanin during domestication 认领 引用 被引量：11
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作者 Zhihao Lu Yue Huang +9 位作者 Sangyin Mao Fangfang Wu Yong Liu Xiangqing Mao Prakash Babu Adhikari Yuantao Xu Lun Wang Hao Zuo Muhammad Junaid Rao Qiang Xu 《Horticulture Research》 SCIE CSCD 2022年第1期3364-3373,共10页
Citric acid and anthocyanin contents were co-selected during Citrus domestication.Pummelo is a founding species in the Citrus genus,but the domestication of pummelo has not beenwell studied.Here,we compared the citric... Citric acid and anthocyanin contents were co-selected during Citrus domestication.Pummelo is a founding species in the Citrus genus,but the domestication of pummelo has not beenwell studied.Here,we compared the citric acid and anthocyanin contents of a lowcitric acid pummelo(Citrusmaxima LCA)and its high citric acid variety(HCA)from the same cultivation area in China.Our study revealed that,unlike the LCA type,the HCA variety accumulated anthocyanin in the pericarp early in fruit development.To investigate the genetic basis of acid and anthocyanin enrichment in HCA pulp and pericarp,respectively,we generated a chromosome-scale HCA genome using long-read sequence reads and Hi-C sequencing data.Transcriptome analysis and transient overexpression assays showed that the accumulation of citric acid and anthocyanin was associated with high expression of CgANTHOCYANIN1(CgAN1),and two different MYBs transcription factors(CgPH4 and CgRuby1),respectively.Moreover,the CgAN1 promoterwasmoremethylated in the LCA pulp than in the HCA pulp.Treatment with a DNA methylation inhibitor,5-azacytidine,alleviated the CgAN1 promoter hypermethylation in the LCA pulp,leading to increased CgAN1 expression and citric acid content.This study provides a new high-quality pummelo genome and insight into the molecular mechanism behind the change in tissue-specific citric acid and anthocyanin accumulation during pummelo domestication and provides a conceptual basis for precise genetic manipulation in fruit flavor breeding. 展开更多
关键词 high citric acid lowcitric acid pummelo citrusmaxima anthocyanin citric acid high quality genome pummelo citric acid anthocyanin tissue specific regulation
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