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Compound heterozygous variants of the DMRTC2 gene are associated with non-obstructive azoospermia in a patient 认领 引用
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作者 Xian-You Gan Yue Meng +5 位作者 Xiao-Bin Ling Lan-Xi Ran Man Yang Teng-Yan Li Yan Sun Bin-bin Wang 《Asian Journal of Andrology》 SCIE CAS CSCD 2026年第2期219-220,共2页
Dear Editor,Male infertility comprises 50%of infertility cases globally,and one of the most severe forms is non-obstructive azoospermia(NOA),which affects approximately 10%–15%of infertile men.1 Genetic factors play ... Dear Editor,Male infertility comprises 50%of infertility cases globally,and one of the most severe forms is non-obstructive azoospermia(NOA),which affects approximately 10%–15%of infertile men.1 Genetic factors play an important role in the pathogenesis of NOA.Recent research progress has increasingly elucidated the pathogenesis of NOA.Multiple studies,particularly those using whole-exome sequencing,have identified an increasing number of pathogenic genes,including meiosis specific with OB-fold(MEIOB),telomere repeat binding bouquet formation protein 1(TERB1),and ubiquitin-specific peptidase 26(USP26)2–4 associated with NOA.These findings have greatly advanced our understanding of the molecular mechanisms underlying the failure of spermatogenesis.However,the genetic etiology of NOA for a considerable number of patients remains to be identified. 展开更多
关键词 non obstructive azoospermia whole exome sequencing dmrtc gene usp compound heterozygous variants male infertility terb meiob
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GlycoPro:A High-Throughput Sample-Processing Platform for Multi-Glycosylation-Omics Analysis 认领 引用
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作者 Xuejiao Liu Yue Meng +4 位作者 Bin Fu Haoru Song Bing Gu Ying Zhang Haojie Lu 《Engineering》 SCIE EI CSCD 2026年第2期43-57,共15页
Glycosylation-omics has emerged as a prominent field for early detection and diagnosis by identifying alterations in glycosylation patterns linked to cancer.In the realm of clinical multi-glycosylation-omics applicati... Glycosylation-omics has emerged as a prominent field for early detection and diagnosis by identifying alterations in glycosylation patterns linked to cancer.In the realm of clinical multi-glycosylation-omics applications,there is a critical need for robust,efficient,and cost-effective preprocessing methodologies capable of handling large sample cohorts.To bridge this gap,we introduce the GlycoPro platform,an innovative solution designed to overcome the limitations of existing analysis methods.Tailored for multi-glycosylation-omics sample preprocessing,GlycoPro refines existing workflows by seamlessly integrating steps including protein extraction,desalting,digestion,derivatization,and enrichment.The GlycoPro platform employs a 96-well plate format,enabling the efficient enrichment or desalting of up to 384 samples in a single day.This capability represents a significant increase in throughput,meeting the demands of large-scale clinical sample preprocessing for mass spectrometry analysis.The GlycoPro platform was used to successfully enrich serum N-glycans from breast cancer patients,revealing unique glycomic signatures that distinguish malignant from benign conditions.We have developed a robust Nglycan biomarker panel,demonstrating a sensitivity of 88.24%and a specificity of 78.95%in diagnostics. 展开更多
关键词 Multi-glycosylation-omics High-throughput Sample preparation Biomarkers Breast cancer
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GPS-Synchronized Monitoring of Core-Collapse Supernova Bursts with PandaX-4T via Coherent Elastic Neutrino-Nucleus Scattering 认领 引用
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作者 Binyu Pang Zihao Bo +109 位作者 Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Manna Deng Yingjie Fan Deqing Fang Xuanye Fu Zhixing Gao Yujie Ge Lisheng Geng Karl Giboni Xunan Guo Xuyuan Guo Zichao Guo Chencheng Han Ke Han Changda He Jinrong He Houqi Huang Junting Huang Yule Huang Ruquan Hou Xiangdong Ji Yonglin Ju Xiaorun Lan Chenxiang Li Jiafu Li Mingchuan Li Peiyuan Li Shuaijie Li Tao Li Yangdong Li Zhiyuan Li Qing Lin Jianglai Liu Yuanchun Liu Congcong Lu Xiaoying Lu Lingyin Luo Yunyang Luo Yugang Ma Yajun Mao Yue Meng Ningchun Qi Zhicheng Qian Xiangxiang Ren Dong Shan Xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen Wenliang Sun Xuyan Sun Yi Tao Yueqiang Tian Yuxin Tian Anqing Wang Guanbo Wang Hao Wang Haoyu Wang Jiamin Wang Lei Wang Meng Wang Qiuhong Wang Shaobo Wang Shibo Wang Siguang Wang Wei Wang Xu Wang Zhou Wang Yuehuan Wei Weihao Wu Yuan Wu Mengjiao Xiao Xiang Xiao Kaizhi Xiong Jianqin Xu Yifan Xu Shunyu Yao Binbin Yan Xiyu Yan Yong Yang Peihua Ye Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Siyuan Zhang Shu Zhang Tao Zhang Wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang Li Zhao Kangkang Zhao Jifang Zhou Jiaxu Zhou Jiayi Zhou Ning Zhou Xiaopeng Zhou Zhizhen Zhou Chenhui Zhu PandaX Collaboration 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第2期367-373,共7页
The landmark detection of neutrinos from SN1987A marked the dawn of neutrino astrophysics.The neutrino burst provided essential insights into fundamental properties of neutrinos and served as key probes of stellar evo... The landmark detection of neutrinos from SN1987A marked the dawn of neutrino astrophysics.The neutrino burst provided essential insights into fundamental properties of neutrinos and served as key probes of stellar evolution and supernova dynamics.The recent advancement in coherent elastic neutrino-nucleus scattering enables the detection of core-collapse supernova burst neutrinos using tonne-scale liquid xenon detectors originally designed for dark matter direct detection.Leveraging this capability,we developed and deployed an online supernova monitoring system for the PandaX-4T experiment.This system features a GPS module with millisecond-level timing precision,a low false-alarm rate,and high sensitivity to galactic core-collapse supernova explosion events.The methodology is robust,directly scalable,and planned for implementation in the next-generation PandaX-20T experiment. 展开更多
关键词 dark matter direct detectionleveraging GPS synchronized monitoring neutrino astrophysics dark matter direct detection core collapse supernova supernova monitoring system PandAX t coherent elastic neutrino nucleus scattering
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USP29 Represses the Osteoclastic Differentiation of Human CD14+ Peripheral Blood Mononuclear Cells by Stabilizing MafB 认领 引用
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作者 Shaoyu Hu Bingquan Li +4 位作者 Jianfeng Ouyang Yue Meng Jian Ji Xiaofei Zheng Yongheng Ye 《BIOCELL》 SCIE 2026年第2期166-180,共15页
Objectives Dysregulated osteoclast function contributes to skeletal diseases.However,the specific ubiquitination regulators of the osteoclastogenesis repressor MafB,particularly at the post-translational level,remain ... Objectives Dysregulated osteoclast function contributes to skeletal diseases.However,the specific ubiquitination regulators of the osteoclastogenesis repressor MafB,particularly at the post-translational level,remain undefined.This study aims to identify ubiquitin-specific proteases(USPs)that deubiquitinate MafB and enhance its stability.Methods We constructed a MafB-conjugated luciferase and overexpressed 40 individual USPs,measuring changes in luciferase activity.The identified USP was overexpressed in human CD14+ peripheral blood mononuclear cells(PBMCs)to evaluate its effect.Osteoclast differentiation was assessed through osteoclast marker Integrin alpha-V(CD51)staining and Western blot analysis.Co-immunoprecipitation(co-IP)was performed to assess the interplay.The influence on MafB ubiquitination and degradation was evaluated via immunoprecipitation and Western blot.Finally,MafB was knocked down in the USP-overexpressing PBMCs to analyze its effect on osteoclast differentiation.Results Overexpression of ubiquitin-specific protease 29(USP29)significantly increased MafB expression by approximately 75%(p<0.0001).Elevated USP29 levels strongly inhibited osteoclastic differentiation in CD14+ PBMCs(p<0.0001).USP29 was found to interact with MafB,markedly reducing its ubiquitination and subsequent degradation in PBMCs(p<0.001).Knocking down MafB in USP29-overexpressing PBMCs alleviated the inhibitory effect of USP29 on osteoclastogenesis.Conclusion USP29 acts as a potent stabilizer of MafB,inhibiting osteoclastogenesis in human CD14+ PBMCs,at least in part,by enhancing MafB stability.These findings expand our understanding of USP29’s role and the post-translational regulation of MafB.Furthermore,USP29 serves as a vital factor that controls osteoclast differentiation,and its regulatory function is at least partially mediated by deubiquitinating and stabilizing MafB. 展开更多
关键词 MAF bZIP transcription factor B(MafB) osteoclast differentiation peripheral blood mononuclear cell ubiquitin-specifc protease USP29 CD14+
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Multiple Regression Situation Assessment for Air Traffic Management Based on SSA-BiLSTM 认领 引用
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作者 Wang Qing Bai Zhuoning +2 位作者 Wu Zhijun Lu Yanrong Yue Meng 《China Communications》 SCIE EI CSCD 2026年第5期271-286,共16页
The air traffic management(ATM)system is one of the important national information infrastructures,and its information security is crucial.According to the requirements of the aviation cybersecurity strategy released ... The air traffic management(ATM)system is one of the important national information infrastructures,and its information security is crucial.According to the requirements of the aviation cybersecurity strategy released by the international civil aviation organization(ICAO)in October 2019,it is necessary to achieve security situational awareness of ATM systems.This paper proposes an ATM multiple regression situation assessment model based on the sparrow search algorithm bidirectional long short-term memory(SSA-BiLSTM),considering the characteristics of wide area distribution and multi-source heterogeneous data in ATM systems.This model utilizes sparse autoencoder(SAE)to extract multivariate and time series features of ATM system data,and uses sparrow search algorithm(SSA)to optimize the hyperparameters of BiLSTM model,reducing the influence of subjective factors on security situation assessment results and solving the problem of subjective interference in existing situation assessment methods.This paper compares the SSA-BiLSTM model with other situational assessment methods.The mean absolute error(MAE)on the standard dataset is 0.0027,outperforming other methods and demonstrating advantages.In tests on the ATM dataset,due to its high nonlinearity,noise interference,and temporal dependencies,the model’s MAE reached 0.36744,which outperforms other approaches and meets the practical requirements of the ATM environment. 展开更多
关键词 ATM BiLSTM situational assessment models SSA
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自适应特征的轻量化路面裂缝检测方法 认领 引用
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作者 刘媛媛 朱凯 +3 位作者 顾志辉 岳猛 王靖智 朱路 《光学精密工程》 EI CAS CSCD 北大核心 2026年第2期336-351,共16页
针对路面裂缝形态复杂、易受环境干扰,且检测存在精度与轻量化不平衡等问题,本文提出一种自适应特征的轻量化路面裂缝检测方法。首先,根据裂缝狭长且跨度大的特点,设计了裂缝高效注意力机制,通过压缩特征维度,以捕捉其长距离空间依赖。... 针对路面裂缝形态复杂、易受环境干扰,且检测存在精度与轻量化不平衡等问题,本文提出一种自适应特征的轻量化路面裂缝检测方法。首先,根据裂缝狭长且跨度大的特点,设计了裂缝高效注意力机制,通过压缩特征维度,以捕捉其长距离空间依赖。其次,构建动态采样金字塔进行自适应采样和提取目标特征,以增强对异构裂缝特征的表示能力。然后,改进HGNet_GS轻量化主干网络,并提出了轻量化检测头,显著降低了计算冗余;采用Powerful IoU损失函数解决框锚膨胀问题并提升小模型的收敛速度。此外为验证模型泛化性,自建了民用路面缺陷数据集,其中包含不同光照条件下路面缺陷共计2985张。实验结果表明,与基准模型YOLOv8n相比,本文模型参数量和计算量分别减少了50%和52%。在自建数据集上,mAP50和mAP95分别提升了5.4%和4.1%;在公开的RDD2022数据集上,mAP50和mAP95分别提升了2.1%和1.5%。该模型已应用于边缘设备并完成工程作业测试,验证了其能够满足轻量化路面裂缝检测的工程应用需求,为自动化道路维护提供了技术方案。 展开更多
关键词 路面裂缝检测 注意力机制 轻量化 动态采样金字塔 YOLOv8
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Construction of ultrathin BiVO4nanosheets with bismuth-oxygen dual vacancies for photocatalytic nitrogen reduction 认领 引用
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作者 Jiahui Chen Yue Meng +2 位作者 Bo Xie Zheming Ni Shengjie Xia 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第11期265-278,共14页
The efficient utilization of photogenerated electrons and the effective activation of reactive molecules are among the major challenges in photocatalytic nitrogen reduction.Defect engineering can enhance the catalyst&... The efficient utilization of photogenerated electrons and the effective activation of reactive molecules are among the major challenges in photocatalytic nitrogen reduction.Defect engineering can enhance the catalyst's ability to adsorb and activate N2and H2O,while the ultrathin structure with maximized active crystal facets can maximize the enrichment of effective photogenerated electrons.This work employs a two-step synergistic method to fabricate ultrathin BiVO4with oxygen vacancies and bismuth vacancies(2D-VBi+O-BVO,thickness<20 nm)for photocatalytic nitrogen reduction.Scanning electron microscopy,transmission electron microscopy(TEM),and atomic force microscopy characterization confirm the transformation of BiVO4from bulk material(bulk-BVO,~1300 nm)to an ultrathin structure(~15 nm).TEM,X-ray photoelectron spectroscopy,electron paramagnetic resonance characterizations,and density functional theory(DFT)calculations verify the construction of oxygen and bismuth vacancies in the ultrathin BiVO4.Compared to bulk-BVO,the photocatalytic nitrogen fixation efficiency of 2D-VBi+O-BVO is increased by 4.7 times,with the highest activity reaching 158.73μmol·g-1·h-1.N2-temperature programmed desorption and DFT calculations demonstrate that the oxygen and bismuth vacancies in BiVO4,respectively,promote the adsorption/activation of N2and H2O,which is crucial for the overall nitrogen reduction reaction.Photo-deposition experiments prove that the(040)plane is the active surface for electrons.And the ultrathin structure maximizes the(040)facet of BiVO4,which is conducive to the high enrichment of electrons.Meanwhile,more active sites can be exposed for the activation of N2and H2O.In situ infrared spectroscopy confirms that N2can be effectively adsorbed onto 2D-VBi+O-BVO,and the presence of NH2-NH2active species is consistent with the alternating reaction pathway.This study provides new insights into the development of green and efficient photocatalysts with dual vacancies and ultrathin structures. 展开更多
关键词 Oxygen vacancies Bismuth vacancies Ultrathin structures Photocatalysis Nitrogen reduction
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Optimizing neon-based gas mixtures for two-stage amplification fast-timing Micromegas detectors 认领 引用
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作者 Yue Meng Xu Wang +3 位作者 Jianbei Liu Ming Shao Zhiyong Zhang Yi Zhou 《中国科学技术大学学报》 CAS CSCD 北大核心 2025年第4期59-66,58,I0002,共8页
The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process th... The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process that leads to a significant deterioration of non-uniformity when scaling up to larger areas.Since the performance of gaseous detectors is highly dependent on the choice of working gas,optimizing the gas mixture offers a promising solution to improve the uniformity performance.This paper addresses these challenges through a combined approach of simulation based on Garfield++and experimental studies.The simulation investigates the properties of different mixing fractions of gas mixtures and their impact on detector performance,including gain uniformity and time resolution.To verify the simulation results,experimental tests were conducted using a multi-channel PICOSEC MM prototype with different gas mixtures.The experimental results are consistent with the findings of the simulation,indicating that a higher concentration of neon significantly improves the detector’s gain uniformity.Furthermore,the influence of gas mixtures on time resolution was explored as a critical performance indicator.The study presented in this paper offers valuable insights for improving uniformity in large-area PICOSEC MM detectors and optimizing overall performance. 展开更多
关键词 gaseous detectors Micromegas timing detectors fast-timing Micromegas Monte Carlo simulation gain uniformity
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Comprehensive Evaluation of Biomechanical and Biological Properties of the Porous Irregular Scaffolds Based on Voronoi-tessellation 认领 引用
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作者 Yuzhu Wang Chenhao Ma +3 位作者 Yufeng Wu Dawei Gao Yue Meng Haibin Wang 《Journal of Bionic Engineering》 SCIE EI CSCD 2025年第1期322-340,共19页
The irregular porous structure,similar to human bone tissue,is more beneficial for bone ingrowth than the regular one.We proposed a new design method to create uniform and gradient irregular porous structures with por... The irregular porous structure,similar to human bone tissue,is more beneficial for bone ingrowth than the regular one.We proposed a new design method to create uniform and gradient irregular porous structures with porosities from 38 to 83%based on Voronoi tessellation.The models were fabricated using selective laser sintering,and micro-CT was used to assess their morphological features.Mechanical and fluid flow properties were evaluated through experiments and computational fluid dynamics simulations.Micro-CT scans confirmed that 3D printing can produce high-quality irregular structures.The Graded Irregular(GI)structure showed clear advantages in mechanical properties by reducing stress shielding and improving hydrodynamic performance with higher fluid flow velocity and lower permeability compared to the Uniform Irregular(UI)structure.Additionally,in vitro cell experiments indicated that the GI structure was better than the UI structure in promoting osteogenic differentiation,while in vivo animal studies showed that the GI structure was superior in terms of the ratio of Bone Volume to Total Volume(BV/TV)and Trabecular Number(Tb.N).Thus,the GI structure has greater application potential in bone tissue engineering. 展开更多
关键词 Irregular structure Mechanical properties Fluid dynamic Bone growth
Self-Assembly of Active Ingredients in Natural Traditional Chinese Medicine as the Controlled Drug Delivery and Targeted Treatment 认领 引用
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作者 Huaao Jiang Bianyifan Xu +7 位作者 Yang Gui Ying Xia Xu Yin Chao Zhang Yue Meng Xin Yu Yan Wang Hongmei Xia 《Journal of Polymer Materials》 SCIE CAS 2025年第4期993-1033,共41页
Traditional Chinese medicine(TCM)has a long history and is widely used to prevent and treat various diseases.With the development of modern technology,an increasing number of active ingredients—such as curcumin,berbe... Traditional Chinese medicine(TCM)has a long history and is widely used to prevent and treat various diseases.With the development of modern technology,an increasing number of active ingredients—such as curcumin,berberine,and baicalin—have been identified and validated within TCM.Concurrently,the emergence of nanotechnology has led to the discovery of numerous nanomedicines based on the self-assembly of active ingredients from TCM.Polymer materials can enhance the bioavailability of these active compounds and reduce their toxic side effects.Moreover,compared to synthetic polymers,natural polymer materials offer advantages such as non-toxicity and high biosafety when used in drug delivery systems.However,natural polymers tend to be unstable and are easily influenced by environmental factors such as temperature,humidity,and pH,which complicates quality control.Additionally,the cost of obtaining natural polymer materials remains high.This article summarizes and analyzes 232 pieces of the research studies on self-assembled polymer materials via noncovalent interactions,including hydrogen bonding,π-πinteractions,hydrophobic interactions,and electrostatic interactions.The review primarily focuses on the active ingredients derived from TCM and provides a concise overview of future directions for polymer materials,including controlled drug delivery,targeted disease treatment,clinical translation,and green synthesis methods. 展开更多
关键词 Self-assembly active ingredients in natural traditional Chinese medicine controlled drug delivery polymer materials nanoparticles
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COSMO-RS筛选离子液体分离异丙醇-乙腈机理分析 认领 引用 被引量：1
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作者 范俊刚 孟月 +2 位作者 赫明鑫 郝家锐 李文秀 《过程工程学报》 CAS CSCD 北大核心 2025年第1期53-61,共9页
高效分离化工生产中产生的醇腈类共沸物是化学工业领域的一项难题,该领域中应用较广泛的萃取精馏技术对萃取剂的选择及机理分析提出了更进一步的要求。利用COSMO-RS模型辅助,通过量化计算预测流体热力学性质,从大量可能溶剂中筛选出适... 高效分离化工生产中产生的醇腈类共沸物是化学工业领域的一项难题,该领域中应用较广泛的萃取精馏技术对萃取剂的选择及机理分析提出了更进一步的要求。利用COSMO-RS模型辅助,通过量化计算预测流体热力学性质,从大量可能溶剂中筛选出适用于某一混合体系的离子液体(ILs)萃取剂,可显著减少实验量,提高研究效率。通过模型预测值与实验值的对比,验证了COSMO-thermX软件预测离子液体分离醇腈共沸物效果的准确性。以ILs的分离选择性、ILs对异丙醇(IPA)-乙腈(MeCN)混合物近沸点处相对挥发度的影响以及ILs对于IPA的溶解度为指标,分析了由24种阳离子和19种阴离子组成的456种ILs对IPA-MeCN的分离效果的影响规律。筛选得到四乙基醋酸铵([N2,2,2,2][Ac])为最佳萃取剂。进一步利用超额焓分析、相互作用能分析和弱相互作用分析等方法研究混合物中IPA、MeCN分子与[N2,2,2,2][Ac]的相互作用,探讨了[N2,2,2,2][Ac]为萃取剂分离IPA-MeCN的分子间分离作用机理。结果表明,[N2,2,2,2][Ac]与IPA之间的相互作用强于MeCN,从而加速了原有共沸结构的破坏。COSMO-RS模型辅助筛选ILs萃取剂及分离机理分析为进一步了解离子液体在共沸体系分离中的作用提供了重要的信息,对新型萃取精馏技术中萃取剂的开发具有一定的参考价值。 展开更多
关键词 异丙醇 乙腈 离子液体 COSMO-RS模型 分离机理
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水性聚氨酯对羧基化纳米纤维素/水性环氧树脂复合材料的增韧研究 认领 引用 被引量：1
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作者 岳萌 胡立新 +3 位作者 莫涯 吴万超 赵远东 胡传群 《化工新型材料》 CAS CSCD 北大核心 2025年第3期111-114,共4页
在羧基化纳米纤维素(CNF)增韧环氧树脂(EP)研究基础上,利用物理共混法,以水性聚氨酯(WPU)为增韧剂,制备了羧基化纳米纤维素/水性聚氨酯/水性环氧树脂(CNF/WPU/WEP)复合材料,并通过力学性能测试研究了WPU对CNF/WEP复合材料的增韧效果。... 在羧基化纳米纤维素(CNF)增韧环氧树脂(EP)研究基础上,利用物理共混法,以水性聚氨酯(WPU)为增韧剂,制备了羧基化纳米纤维素/水性聚氨酯/水性环氧树脂(CNF/WPU/WEP)复合材料,并通过力学性能测试研究了WPU对CNF/WEP复合材料的增韧效果。通过扫描电子显微镜、X射线衍射仪、热重分析仪研究了WPU对CNF/WEP复合材料的增韧机理以及热稳定性的影响。结果表明:当WPU质量分数为15%时,增韧效果最佳;CNF/WPU/WEP复合材料拉伸强度达到25.39MPa,冲击强度达到205.22kJ/m2,初始分解温度可达到307℃。 展开更多
关键词 水性聚氨酯 协同增韧 水性环氧树脂 羧基化纳米纤维素
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近断层地震动特性对重力坝地震响应影响研究 认领 引用
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作者 陈灯红 张心瀚 +3 位作者 林天成 岳梦 王睿楠 曾怡阳 《地震工程与工程振动》 CSCD 北大核心 2025年第2期106-117,共12页
基于太平洋地震工程研究中心数据库,依据地震台站的断层距离对所收集的地震记录进行划分,研究不同场地条件下地震动的幅值、频谱和持时特性并进行量化分析;以黄登重力坝为研究对象,从上游坝面顺河向位移、上游坝面主拉应力和下游坝面主... 基于太平洋地震工程研究中心数据库,依据地震台站的断层距离对所收集的地震记录进行划分,研究不同场地条件下地震动的幅值、频谱和持时特性并进行量化分析;以黄登重力坝为研究对象,从上游坝面顺河向位移、上游坝面主拉应力和下游坝面主压应力3个响应量出发,探究近断层地震的脉冲特性对重力坝地震响应的影响。研究结果表明:脉冲地震下的黄登重力坝坝顶坝趾顺河向相对位移比非脉冲大44%;坝踵处的主拉应力比非脉冲型大30%;坝趾处的主压应力则比非脉冲地震的响应值大31%。相比于非脉冲型地震,脉冲型地震对结构造成的影响不可忽略,结构的各项响应值均明显偏大。因此,在进行抗震设防时需要考虑近断层地震的脉冲作用。 展开更多
关键词 近断层 地震动 重力坝 脉冲特性 地震响应
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聚氨酯化学传感器研究进展 认领 引用
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作者 黄晓悦 莫涯 +3 位作者 岳萌 吴万超 胡立新 胡传群 《化工新型材料》 CAS CSCD 北大核心 2025年第7期267-271,共5页
近年来,随着环境污染生物医学和化学分析等领域对化学传感器的需求不断增加,高灵敏度、高选择性和快速响应的新型传感器成为当下研究的热点。综述了聚氨酯化学传感器在不同领域的应用,并对其发展前景进行展望。
关键词 化学传感器 聚氨酯 应用
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水性聚氨酯阻燃复合材料研究进展 认领 引用
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作者 吴万超 莫涯 +2 位作者 岳萌 黄晓悦 胡传群 《化工新型材料》 CAS CSCD 北大核心 2025年第7期15-17,23,共3页
介绍了水性聚氨酯材料的阻燃机理以及添加型阻燃和反应型阻燃对水性聚氨酯改性研究的现状;对现有阻燃改性水性聚氨酯材料的阻燃性能进行了概述;并对水性聚氨酯阻燃复合材料在更广泛的领域应用进行了综述和展望。
关键词 水性聚氨酯 阻燃 复合材料
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血必净注射液干预cGAS/STING通路对脓毒症急性肺损伤的改善作用 认领 引用 被引量：8
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作者 秦响英 张力元 +3 位作者 唐嘉辉 岳孟 寇俊萍 张媛媛 《中国药科大学学报》 CAS CSCD 北大核心 2025年第3期350-357,共8页
探讨血必净注射液(Xuebijing injection,XBJ)干预cGAS/STING通路减轻脓毒症诱导的急性肺损伤(acute lung injury,ALI)的作用。采用盲肠结扎与穿刺(CLP)建立小鼠脓毒症ALI模型,LPS刺激RAW264.7细胞构建细胞炎症模型。利用HE染色、ELISA法... 探讨血必净注射液(Xuebijing injection,XBJ)干预cGAS/STING通路减轻脓毒症诱导的急性肺损伤(acute lung injury,ALI)的作用。采用盲肠结扎与穿刺(CLP)建立小鼠脓毒症ALI模型,LPS刺激RAW264.7细胞构建细胞炎症模型。利用HE染色、ELISA法、Western blot等方法,考察XBJ对脓毒症小鼠肺组织损伤与cGAS/STING通路相关蛋白表达的影响。结果发现,在体内,XBJ干预能够缓解肺组织损伤,降低血清IL-6、TNF-α、IFN-β、IL-1β水平,肺组织cGAS、STING、p-TBK1和p-IRF3蛋白的表达。在体外,XBJ干预后能够降低RAW264.7细胞相关炎症因子mRNA水平,以及c GAS/STING通路蛋白的表达。结果表明,XBJ能够通过抑制cGAS/STING通路活化,抑制炎症反应而发挥防治脓毒症ALI的作用。本研究为临床XBJ防治脓毒症ALI提供新的分子机制。 展开更多
关键词 脓毒症 急性肺损伤 血必净注射液 cGAS/STING通路
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Methane–air explosion characteristics with different obstacle configurations 认领 引用 被引量：21
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作者 Wen Xiaoping Yu Minggao +2 位作者 Ji Wentao Yue Meng Chen Junjie 《International Journal of Mining Science and Technology》 EI CAS CSCD 2015年第2期213-218,共6页
To investigate the flame and overpressure characteristics of methane–air explosion with different obstacle configurations,an experimental study has been conducted,taking account of the number of obstacles,obstacle di... To investigate the flame and overpressure characteristics of methane–air explosion with different obstacle configurations,an experimental study has been conducted,taking account of the number of obstacles,obstacle distance from ignition source,and stream-wise and cross-wise obstacle positions.The results show that the flame speed and peak overpressure increase with the increasing number of obstacles,while the time to reach the peak is not fully determined by it.And the configuration having the farthest obstacle produces a higher overpressure and takes a longer time to reach the peak,but a slower flame propagation speed is obtained.Similar explosion characteristics are also observed in the configurations with two obstacles fixed at different stream-wise positions.Furthermore,the experimental results demonstrate that the peak overpressures and flame speeds in configurations with central or staggered obstacles are relatively higher,which should to be avoided in practical processes to minimize the risk associated with methane–air explosion. 展开更多
关键词 Methane-air explosion Obstacle configurations Flame propagation Overpressure
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Farmers’precision pesticide technology adoption and its influencing factors:Evidence from apple production areas in China 认领 引用 被引量：7
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作者 YUE Meng LI Wen-jing +7 位作者 JIN Shan CHEN Jing CHANG Qian Glyn JONES CAO Yi-ying YANG Gui-jun LI Zhen-hong Lynn JFREWER 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第1期292-305,共14页
The research aimed to understand farmers’willingness to adopt(WTA)and willingness to pay(WTP)for precision pesticide technologies and analyzed the determinants of farmers’decision-making.We used a two-stage approach... The research aimed to understand farmers’willingness to adopt(WTA)and willingness to pay(WTP)for precision pesticide technologies and analyzed the determinants of farmers’decision-making.We used a two-stage approach to consider farmers’WTA and WTP for precision pesticide technologies.A survey of 545 apple farmers was administered in Bohai Bay and the Loess Plateau in China.The data were analyzed using the double-hurdle model.The results indicated that 78.72%of respondents were willing to apply precision pesticide technologies provided by service organizations such as cooperatives and dedicated enterprises,and 69.72%were willing to buy the equipment for using precision pesticide technologies.The results of the determinant analysis indicated that farmers’perceived perceptions,farm scale,cooperative membership,access to digital information,and availability of financial services had significant and positive impacts on farmers’WTA precision pesticide technologies.Cooperative membership,technical training,and adherence to environmental regulations increased farmers’WTP for precision pesticide technologies.Moreover,nonlinear relationships between age,agricultural experience,and farmers’WTA and WTP for precision pesticide technology services were found. 展开更多
关键词 precision technologies apple production precision pesticides willingness to adopt willingness to pay
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A hybrid heterogeneous Pythagorean fuzzy group decision modelling for crowdfunding development process pathways of fintech‑based clean energy investment projects 认领 引用 被引量：5
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作者 Yue Meng Haoyue Wu +3 位作者 Wenjing Zhao Wenkuan Chen Hasan Dincer Serhat Yuksel 《Financial Innovation》 2021年第1期689-721,共33页
This study aims to evaluate the crowdfunding alternatives regarding new service development process pathways of clean energy investment projects.In this framework,a new model has been generated by considering the cons... This study aims to evaluate the crowdfunding alternatives regarding new service development process pathways of clean energy investment projects.In this framework,a new model has been generated by considering the consensus-based group decisionmaking with incomplete preferences,Pythagorean fuzzy decision-making trial and evaluation laboratory(DEMATEL)and technique for order preference by similarity to ideal solution(TOPSIS).Moreover,a comparative evaluation has been performed with Vise Kriterijumska Optimizacija I.Kompromisno Resenje methodology and sensitivity analysis has been made by considering 4 different cases.The main contribution is to identify appropriate crowdfunding-based funding alternatives for the improvement of the clean energy investments with a novel MCDM model.By considering the iteration technique and consensus-based analysis,the missing parts in the evaluations can be completed and opposite opinion problems can be reduced.Furthermore,with the help of hybrid MCDM model by combining DEMATEL and TOPSIS,more objective results can be reached.It is concluded that the analysis results are coherent and reliable.The findings indicate that the full launch is the most significant criterion for equity and debt-based crowdfunding alternatives.On the other side,the analysis has the highest weight for reward and donation-based alternatives whereas design is the most essential item regarding the royalty-based alternative.Additionally,it is also defined that equity-based crowdfunding alternative is the most significant for the service development process of clean energy investment projects.In this way,it will be possible to provide a continuous resource for clean energy investment projects.On the other hand,by providing financing with equity,there will be no fixed financing cost for clean energy investors.If these investors make a profit,they distribute dividends with the decision of their authorized bodies. 展开更多
关键词 Crowdfunding Project financing Clean energy investments New service development PERT Group decision making Pythagorean fuzzy sets DEMATEL TOPSIS VIKOR
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Crystallography of low Z material at ultrahigh pressure:Case study on solid hydrogen 认领 引用 被引量：8
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作者 Cheng Ji Bing Li +19 位作者 Wenjun Liu Jesse S.Smith Alexander Bjoorling Arnab Majumdar Wei Luo Rajeev Ahuja Jinfu Shu Junyue Wang Stanislav Sinogeikin Yue Meng Vitali B.Prakapenka Eran Greenberg Ruqing Xu Xianrong Huang Yang Ding Alexander Soldatov Wenge Yang Guoyin Shen Wendy L.Mao Ho-Kwang Mao 《Matter and Radiation at Extremes》 SCIE EI 2020年第3期40-54,共15页
Diamond anvil cell techniques have been improved to allow access to the multimegabar ultrahigh-pressure region for exploring novel phenomena in condensedmatter.However,the onlyway to determine crystal structures of ma... Diamond anvil cell techniques have been improved to allow access to the multimegabar ultrahigh-pressure region for exploring novel phenomena in condensedmatter.However,the onlyway to determine crystal structures of materials above 100 GPa,namely,X-ray diffraction(XRD),especially for lowZ materials,remains nontrivial in the ultrahigh-pressure region,even with the availability of brilliant synchrotron X-ray sources.In thiswork,we performa systematic study,choosing hydrogen(the lowest X-ray scatterer)as the subject,to understand how to better perform XRD measurements of low Z materials at multimegabar pressures.The techniques that we have developed have been proved to be effective in measuring the crystal structure of solid hydrogen up to 254GPa at room temperature[C.Ji et al.,Nature 573,558–562(2019)].Wepresent our discoveries and experienceswith regard to several aspects of thiswork,namely,diamond anvil selection,sample configuration for ultrahigh-pressure XRDstudies,XRDdiagnostics for low Z materials,and related issues in data interpretation and pressure calibration.Webelieve that these methods can be readily extended to other low Z materials and can pave the way for studying the crystal structure of hydrogen at higher pressures,eventually testing structural models of metallic hydrogen. 展开更多
关键词 ultrahigh solid eventually
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