期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到57篇文章
< 1 2 3 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Photodynamic therapy promotes hypoxia-activated nitrogen mustard drug release 认领 引用 被引量：2
1
作者 Ran Wang Maomao He +6 位作者 Zongwei Zhang Tian Qiu Yue Xi Xiaolong Zeng Jiangli Fan Wen Sun Xiaojun Peng 《Smart Molecules》 2024年第3期94-101,共8页
Photodynamic therapy(PDT)has become a promising method for tumor treatment due to its non-invasive and high spatiotemporal selectivity.However,PDT is still hindered by reactive oxygen species deficiency,because solid ... Photodynamic therapy(PDT)has become a promising method for tumor treatment due to its non-invasive and high spatiotemporal selectivity.However,PDT is still hindered by reactive oxygen species deficiency,because solid tumors feature a hypoxic microenvironment.PDT combined with hypoxia-activated chemotherapy drugs can effectively induce tumor death,overcoming the limitations of the sole PDT for the fight against hypoxia.Herein,we designed a nanosystem(PCe6AZOM)that enhances the release of hypoxia-activated drugs(AZOM)by PDT.Under hypoxic conditions,the azo bond of AZOM is cleaved by azo reductase,releasing highly cytotoxic AZOM and resulting in a significant increase in intratumor drug concentration.Meanwhile,the commercial photosensitizer Ce6 can aggravate the oxygen-poor state during the PDT process and further cause more AZOM release.Moreover,the cascade reactions in the nanosystem could activate singlet oxygen and enhance drug release through 660 nm light laser irradiation,contributing to more effective induction of tumor apoptosis and tumor growth retardation in vitro and in vivo. 展开更多
关键词 cascade reaction chemotherapy hypoxia-activated photodynamic therapy prodrug
暂未订购 下载PDF
Novel frameshift mutation causes early termination of the thyroxine-binding globulin protein and complete thyroxine-binding globulin deficiency in a Chinese family: A case report 认领 引用 被引量：1
2
作者 Ping-Ping Dang Wei-Wei Xiao +5 位作者 Zhong-Yan Shan Yue Xi Ran-Ran Wang Xiao-Hui Yu Wei-Ping Teng Xiao-Chun Teng 《World Journal of Clinical Cases》 SCIE 2019年第22期3887-3894,共8页
BACKGROUND Thyroxine-binding globulin(TBG;the gene product of SERPINA7)is the main transporter of thyroid hormones in humans.Mutations in the TBG gene may lead to inherited TBG deficiency.There have been 28 reported m... BACKGROUND Thyroxine-binding globulin(TBG;the gene product of SERPINA7)is the main transporter of thyroid hormones in humans.Mutations in the TBG gene may lead to inherited TBG deficiency.There have been 28 reported mutations that associate with complete TBG deficiency(TBG-CD).Here we identified a novel frameshift mutation causing early termination of the TBG protein and TBG-CD in a Chinese family.CASE SUMMARY A 46-year-old Chinese man was referred to our hospital with normal free thyroxine,free triiodothyronine,thyrotropin,but lower total thyroxine and total triiodothyronine,and undetectable serum TBG,indicative of TBG-CD.Blood samples were obtained from the patient’s family members and thyroid function and serum TBG were evaluated.Genomic DNA from peripheral blood was sequenced to detect possible TBG mutation(s).Quantitative PCR high-resolution melting curve analysis was used to screen TBG-Poly(L283F)among 117 Chinese men.A novel mutation of TBG(p.Phe135Alafs*21),a 19-nucleotide insertion in exon 1,was identified,which resulted in a truncated TBG protein product and caused TBG-CD.The other mutation,identified in the proband’s father,is a known polymorphism,TBG-Poly(L283F).The frequency of the TBG-Poly allele among 117 unrelated Han Chinese men from northeast China was 21.37%.CONCLUSION A novel mutation in the TBG gene associated with the TBG-CD phenotype was identified in a Chinese family.Additionally,it was found that 21.37%of Chinese males had TBG-Poly(L283F). 展开更多
关键词 Thyroxine-binding globulin Complete thyroxine-binding globulin deficiency Partial thyroxine-binding globulin deficiency Gene polymorphism Case report
暂未订购 下载PDF
Subhepatic ectopic pregnancy in Müllerian anomaly localized by large-field-of-view magnetic resonance imaging:A case report 认领 引用
3
作者 Wen-Jing Huang Xiao-Rui Zhao +4 位作者 Yu-Qing Cao Xiao-Zhu Huang Wen-Li Lai Yue Xi Hui-Ying Wu 《World Journal of Clinical Cases》 2026年第8期49-53,共5页
BACKGROUND Ectopic pregnancy(EP)is rarely associated with congenital Müllerian anomalies,such as unicornuate uterus and undescended fallopian tube pregnancy.When EP occurs in extra-pelvic locations like the subhe... BACKGROUND Ectopic pregnancy(EP)is rarely associated with congenital Müllerian anomalies,such as unicornuate uterus and undescended fallopian tube pregnancy.When EP occurs in extra-pelvic locations like the subhepatic space,diagnosis is often challenging,particularly when initial pelvic imaging is inconclusive.CASE SUMMARY We report a rare case of a 28-year-old woman presenting with subhepatic EP.Symptoms included amenorrhea,intermittent right upper abdominal pain,and elevated serum beta human chorionic gonadotropin(β-hCG)level(4087.42 mIU/mL).Transvaginal ultrasound was non-diagnostic,failing to locate the gestational sac or right adnexa.Crucially,large-field-of-view(LFOV)magnetic resonance imaging(MRI)localized the ectopic sac between the inferior hepatic edge and right iliac fossa.Laparoscopy confirmed tubal EP within an undescended right fallopian tube,along with a left unicornuate uterus and contralateral rudimentary horn.CONCLUSION This case underscores the critical diagnostic utility of LFOV MRI in accurately pinpointing extra-pelvic EP when pelvic ultrasound is negative andβ-hCG is high,particularly essential in complex cases involving congenital Müllerian anomalies,thereby facilitating timely,life-saving intervention. 展开更多
关键词 Ectopic pregnancy Unicornuate uterus Undescended adnexa Subhepatic pregnancy Magnetic resonance imaging Large-field-of-view imaging Case report
暂未订购 下载PDF
SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5(LRP5)-dependent osteoporosis mice 认领 引用 被引量：1
4
作者 Yue XI Qifeng JIANG +7 位作者 Wei DAI Chaozhen CHEN Yang WANG Xiaoyan MIAO Kaichen LAI Zhiwei JIANG Guoli YANG Ying WANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2025年第3期254-268,共15页
Loss-of-function variants of low-density lipoprotein receptor-related protein 5(LRP5)can lead to reduced bone formation,culminating in diminished bone mass.Our previous study reported transcription factor osterix(SP7)... Loss-of-function variants of low-density lipoprotein receptor-related protein 5(LRP5)can lead to reduced bone formation,culminating in diminished bone mass.Our previous study reported transcription factor osterix(SP7)-binding sites on the LRP5 promoter and its pivotal role in upregulating LRP5 expression during implant osseointegration.However,the potential role of SP7 in ameliorating LRP5-dependent osteoporosis remained unknown.In this study,we used mice with a conditional knockout(c KO)of LRP5 in mature osteoblasts,which presented decreased osteogenesis.The in vitro experimental results showed that SP7 could promote LRP5 expression,thereby upregulating the osteogenic markers such as alkaline phosphatase(ALP),Runt-related transcription factor 2(Runx2),andβ-catenin(P<0.05).For the in vivo experiment,the SP7 overexpression virus was injected into a bone defect model of LRP5 c KO mice,resulting in increased bone mineral density(BMD)(P<0.001)and volumetric density(bone volume(BV)otal volume(TV))(P<0.001),and decreased trabecular separation(Tb.Sp)(P<0.05).These data suggested that SP7 could ameliorate bone defect healing in LRP5 c KO mice.Our study provides new insights into potential therapeutic opportunities for ameliorating LRP5-dependent osteoporosis. 展开更多
关键词 Gene therapy Low-density lipoprotein receptor-related protein 5(LRP5) Transcription factor osterix(SP7) Osteoporosis Defect healing
暂未订购 下载PDF
Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis 认领 引用
5
作者 Shi Li Yue Xi +3 位作者 Xue-Ying Dong Wen-Bin Yuan Jing-Feng Tang Ce-Fan Zhou 《World Journal of Gastroenterology》 SCIE CAS 2025年第7期156-159,共4页
Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on sp... Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on specific human leukocyte antigen(HLA)alleles,including rs2856718 of HLA-DQ and rs3077 and rs9277535 of HLA-DP,which may predispose individuals to cirrhosis and liver cancer,based on multi-clustering analysis.Here,we discuss the feasibility of this approach and identify key areas for further investigation,aiming to offer insights for advancing clinical practice and research in liver disease and related cancers. 展开更多
关键词 Hepatitis B virus Gene polymorphisms Multi-clustering analysis Genetic markers Personalized medicine Clinical implications
暂未订购 下载PDF
Redox modulation of PGLP1 oligomerization mediated by thioredoxin f is crucial for plant responses to high light and fluctuating light 认领 引用
6
作者 Yue Xi Guangru Li +5 位作者 Qiufei Peng Wenjing Miao Yunru Su Zhisheng Zhang XinXiang Peng Guohui Zhu 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2026年第5期1454-1468,共15页
Photorespiration is essential for maintaining plant photosynthesis and growth under aerobic conditions.While environmental factors like light–dark transitions and high light modulate this pathway,the underlying molec... Photorespiration is essential for maintaining plant photosynthesis and growth under aerobic conditions.While environmental factors like light–dark transitions and high light modulate this pathway,the underlying molecular regulatory mechanisms remain unclear.Here,we report that the activity of phosphoglycolate phosphatase(PGLP),the first enzyme in the photorespiratory pathway,is redox-regulated in response to environmental light conditions.Specifically,Arabidopsis PGLP enzymatic activity enhanced under reducing conditions and light,but suppressed under oxidative conditions and darkness.Light–dark transitions dynamically alter the oligomeric state of PGLP1,as darkness promotes oligomer assembly,while light triggers disassembly,a process critically dependent on cysteine 320(Cys320)of PGLP1.Thioredoxin(Trx)f directly interacts with PGLP1,modulating both;its light-dependent oligomeric state and enzymatic activity.Complementation of the Arabidopsis pglp1-2 mutant with wild-type PGLP1 or the Cys320 mutant(C320S)revealed that C320S-complemented lines show greater tolerance to high-light and fluctuating light conditions.Collectively,our study identifies a redox-dependent post-translational modification mechanism that fine-tunes PGLP activity,thereby optimizing photorespiratory metabolism to enhance plant photosynthetic efficiency and environmental adaptability. 展开更多
关键词 phosphoglycolate phosphatase photorespiration photosynthesis redox modification thioredoxin f
暂未订购 下载PDF
新工科背景下“1+3PBL”教学模式的探索与实践 认领 引用
7
作者 康倩 岳茜 +2 位作者 陶隆凤 金翠玲 杨春成 《中国宝玉石》 2026年第3期73-79,共7页
针对新工科背景下工科专业育人长期存在的价值塑造与知识能力培养“两张皮”困境,本文以矿物材料课程为实践载体,创新性构建了“1+3PBL”教学模式并开展了系统教学实践。该模式以课程思政为引领(“1”),有机融合问题、过程与项目三重导... 针对新工科背景下工科专业育人长期存在的价值塑造与知识能力培养“两张皮”困境,本文以矿物材料课程为实践载体,创新性构建了“1+3PBL”教学模式并开展了系统教学实践。该模式以课程思政为引领(“1”),有机融合问题、过程与项目三重导向(“3P”),通过“问题启思一过程探究一项目驱动”的递进路径,将价值塑造贯穿教学全过程。实践表明,该模式有效促进了学生复杂工程问题解决能力的提升,推动了专业知识学习与家国情怀、工程伦理等价值目标的深度融合,实现了育人成效的提升,为工科课程建设提供了可资借鉴的思路。 展开更多
关键词 1+3PBL 新工科 课程建设 教学模式
暂未订购 下载PDF
Targeting mixed lineage kinase domain-like protein's nonnecroptosis role:A new horizon in anti-inflammatory therapy for alcoholic liver disease 认领 引用
8
作者 Yue Xi Dong Guo +4 位作者 Shi Li Jie-Yu Guo Xing-Zhen Chen Jing-Feng Tang Ce-Fan Zhou 《World Journal of Gastroenterology》 SCIE CAS 2025年第13期158-162,共5页
Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu... Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yuan et al demonstrated that CPD4,an ATP-binding pocket inhibitor of MLKL,significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling,suggesting its use as a potential therapeutic candidate for alcoholic liver disease.However,the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.Moreover,a single therapeutic strategy targeting MLKL may not be sufficient.Future studies should focus on the precise regulation of MLKL and develop combination therapies to achieve dual intervention of inflammatory and cell death pathways.This paper provides an important theoretical foundation for translational research on MLKL-targeted therapy.However,its clinical translation requires overcoming existing limitations and further elucidating the regulatory network of MLKL in complex microenvironments. 展开更多
关键词 Mixed lineage kinase domain-like protein ATP-binding pocket CPD4 inhibitor Alcoholic liver disease Therapeutic targets Liver diseases
暂未订购 下载PDF
Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression 认领 引用 被引量：24
9
作者 Yun-Wei Fu Yan-Fang Peng +7 位作者 Xiao-Dan Huang Yan Yang Lu Huang Yue Xi Zheng-Fang Hu Song Lin Kwok-Fai So Chao-Ran Ren 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第3期543-549,共7页
Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic ... Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017. 展开更多
关键词 aversive stimuli behaviors depression immune response inflammation lateral habenula Lycium barbarum polysaccharide mice microglia neuron
暂未订购 下载PDF
Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A-Smad2/3 in rats following myocardial infarction 认领 引用 被引量：28
10
作者 Yue Xi Meili Hao +3 位作者 Qiaoqin Liang Yongxia Li Da-Wei Gong Zhenjun Tian 《Journal of Sport and Health Science》 SCIE CAS CSCD 2021年第5期594-603,共10页
Purpose:The aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1(FSTL1),which may induce cardioprotection in rats following myocardia... Purpose:The aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1(FSTL1),which may induce cardioprotection in rats following myocardial infarction(MI)by inducing angiogenesis.Methods:Male,adult Sprague-Dawley rats were randomly divided into 5 groups(n=12 in each group):sham group(S),sedentary MI group(MI),MI+resistance exercise group(MR),MI+adeno-associated virus(AAV)-FSTL1 injection group(MA),and MI+AAV-FSTL1 injection+resistance exercise group(MAR).The AAV-FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis muscle.The MI model was established by ligation of the left anterior descending coronary artery.Rats in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up ladder.Heart function was evaluated by hemodynamic measures.Collagen volume fraction of myocardium was observed and analyzed by Masson’s staining.Human umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-b receptor 1(TGFbR1)inhibitor treatment were used to elucidate the molecular signaling mechanism of FSTL1.Angiogenesis,cell proliferation,and disco interacting protein 2 homolog A(DIP2A)location were observed by immunofluorescence staining.The expression of FSTL1,DIP2A,and the activation of signaling pathways were detected by Western blotting.Angiogenesis of endothelial cells was observed by tubule experiment.One-way analysis of variance and Student’s t test were used for statistical analysis.Results:Resistance exercise stimulated the secretion of skeletal muscle FSTL1,which promoted myocardial angiogenesis,inhibited pathological remodeling,and protected cardiac function in MI rats.Exercise facilitated skeletal muscle FSTL1 to play a role in protecting the heart.Exogenous FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated the expression of DIP2A,while TGFbR1 inhibitor intervention down-regulated the phosphorylation level of Smad2/3 and the expression of vascular endothelial growth factor-A,which was not conducive to angiogenesis.FSTL1 bound to the receptor,DIP2A,to regulate angiogenesis mainly through the Smad2/3 signaling pathway.FSTL1-DIP2A directly activated Smad2/3 and was not affected by TGFbR1.Conclusion:Dynamic resistance exercise stimulates the expression of skeletal muscle-derived FSTL1,which could supplement the insufficiency of cardiac FSTL1 and promote cardiac rehabilitation through the DIP2A-Smad2/3 signaling pathway in MI rats. 展开更多
关键词 Angiogenesis Follistatin like-1 Myocardial infarction Resistance exercise Signaling mechanism
暂未订购 下载PDF
基于数据增强和损失平衡的机电领域命名实体识别 认领 引用 被引量：4
11
作者 林娜 岳希 唐聃 《计算机工程与应用》 EI CSCD 北大核心 2025年第7期222-232,共11页
机电领域命名实体识别是机电创新设计信息检索最基础的过程。目前命名实体识别任务的数据在机电领域较少,且大部分存在不平衡问题。通过构建机电领域命名实体识别数据集,根据数据集文本结构特点设计多维数据增强方法,并提出基于改进los... 机电领域命名实体识别是机电创新设计信息检索最基础的过程。目前命名实体识别任务的数据在机电领域较少,且大部分存在不平衡问题。通过构建机电领域命名实体识别数据集,根据数据集文本结构特点设计多维数据增强方法,并提出基于改进loss的命名实体识别模型BERT-BiGRU-CRF(BL)。对互联网机电领域文本语料进行爬取并进行标注构成机电领域命名实体识别数据集;根据不同方式对数据集的影响从同类实体替换、同义词替换、语料裁减和语料拼接四个方面进行多维数据增强后按一定比例进行数据扩充增加数据丰富度;针对数据集数据不平衡问题设计使用Weigh loss平衡focal loss与CRF loss权重的模型,该模型采用BERT进行词向量编码,利用BiGRU完成文本向量的特征提取,使用CRF进行标签约束与解码。经实验证明,多维数据增强方法对模型效果有显著提升,并且经过改进的模型在原始和增强后数据集上表现均为最优,F1值分别为78.23%和83.3%。 展开更多
关键词 机电领域 命名实体识别 数据增强 focal loss Weigh loss
暂未订购 下载PDF
The role of exercise in rehabilitation of discharged COVID-19 patients 认领 引用 被引量：4
12
作者 Wenyan Bo Yue Xi Zhenjun Tian 《Sports Medicine and Health Science》 2021年第4期194-201,共8页
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly caused pneumonia and pulmonary fibrosis through upper respiratory tract infection,which resulted in acute respiratory distress syndrome(ARDS)and multio... Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly caused pneumonia and pulmonary fibrosis through upper respiratory tract infection,which resulted in acute respiratory distress syndrome(ARDS)and multiorgan damage of cardiovascular,nervous,digestive,and genitourinary systems.Although the virus test turned negative after the patient recovered,the damage to multiorgan caused by SARS-CoV-2 may irreversible.Therefore,the health status of the recovered patients has gradually become the focus of people's attention.Whether coronavirus disease 2019(COVID-19)patients can receive exercise rehabilitation training after discharge?and what's the basis?We try to analyze and answer these questions,will provide some ideas about the patients to develop a reasonable and effective exercise rehabilitation program. 展开更多
关键词 SARS-CoV-2 COVID-19 Exercise rehabilitation Inflammation cytokine storm Exercise response factor
暂未订购 下载PDF
Diabetes and gut microbiota 认领 引用 被引量：8
13
作者 Yue Xi Peng-Fei Xu 《World Journal of Diabetes》 SCIE 2021年第10期1693-1703,共11页
The prevalence of diabetes has increased rapidly throughout the world in recent years.Currently,approximately 463 million people are living with diabetes,and the number has tripled over the last two decades.Here,we de... The prevalence of diabetes has increased rapidly throughout the world in recent years.Currently,approximately 463 million people are living with diabetes,and the number has tripled over the last two decades.Here,we describe the global epidemiology of diabetes in 2019 and forecast the trends to 2030 and 2045 in China,India,USA,and the globally.The gut microbiota plays a major role in metabolic diseases,especially diabetes.In this review,we describe the interaction between diabetes and gut microbiota in three aspects:probiotics,antidiabetic medication,and diet.Recent findings indicate that probiotics,antidiabetic medications,or dietary interventions treat diabetes by shifting the gut microbiome,particularly by raising beneficial bacteria and reducing harmful bacteria.We conclude that targeting the gut microbiota is becoming a novel therapeutic strategy for diabetes. 展开更多
关键词 Diabetes Gut microbiota Epidemiology Probiotics Anti-diabetic medication Diet
暂未订购 下载PDF
改进TransCenter的组合距离多目标跟踪方法 认领 引用 被引量：1
14
作者 赵海涛 岳希 +1 位作者 唐聃 蔡博 《计算机工程与应用》 EI CSCD 北大核心 2025年第9期177-185,共9页
在智能驾驶和视频监控领域中,多目标跟踪被广泛应用,但在目标发生遮挡和非线性运动时,此时产生的噪声会造成检测和跟踪精度的降低,同时众多关联匹配算法也没有考虑到IoU和外观失衡的情况。针对以上问题,提出一种基于TransCenter改进的... 在智能驾驶和视频监控领域中,多目标跟踪被广泛应用,但在目标发生遮挡和非线性运动时,此时产生的噪声会造成检测和跟踪精度的降低,同时众多关联匹配算法也没有考虑到IoU和外观失衡的情况。针对以上问题,提出一种基于TransCenter改进的多目标跟踪网络。引用小波变换处理检测特征,设计了上下文协同选择器,通过动态选择跟踪特征和检测特征来缓解噪声产生的负面影响;融合卡尔曼滤波预测值和跟踪位移,以提高非线性运动中的预测位移准确度;根据IoU距离和外观距离的差值优化组合距离的权重,解决了高速运动和外观剧烈变化时组合距离失效的情况。在BDD100k、DanceTrack数据集上进行了实验,结果表明,与ByteTrack算法相比,改进网络的mMOTA和HOTA值分别提升了4.3和5.9个百分点,与TransCenter相比,HOTA提升了7.4个百分点,且有着更好的灵活性和跟踪精度。 展开更多
关键词 多目标跟踪 卡尔曼滤波 上下文协同 组合距离
暂未订购 下载PDF
Advances in CRISPR/Cas technologies and their application in plants 认领 引用 被引量：2
15
作者 Chao Dong Yue Xi +1 位作者 Viswanathan Satheesh Mingguang Lei 《Tropical Plants》 2023年第1期195-204,共10页
Discovery of the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated(CRISPR/Cas)system and its repurposing into a powerful genome editing tool has revolutionized genome engineering and generate... Discovery of the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated(CRISPR/Cas)system and its repurposing into a powerful genome editing tool has revolutionized genome engineering and generated excitement for innovative breeding technology.CRISPR/Cas can perform genetic operations such as targeted insertion,deletion and replacement of genes in plants by its simple two-component system comprising a Cas protein and a guide RNA.Here,we focus on the recent advances in CRISPR/Cas technologies that are available for genome editing,among which Cas9,Cas12,and Cas13 systems are widely used in the areas of botany and agriculture.We also describe the new high-precision genome editing tools,base editors and prime editors that are derived from the Cas9 system and beyond for altering the genome in living cells,without generating double-stranded breaks in DNA or requiring a donor.In addition,we summarize the differences between the different CRISPR/Cas systems and their broad applications in plants.We also discuss the challenges facing the use of CRISPR/Cas technologies and the future directions of CRISPR/Cas systems in plant genome editing. 展开更多
关键词 genome editing tool genome editing CRISPR Cas technologies plant breeding cas protein genetic operations clustered regularly interspaced short palindromic repeats crispr associated crispr cas system innovative breeding technologycrispr cas
暂未订购 下载PDF
Therapeutic potentials of fasudil in liver fibrosis 认领 引用
16
作者 Yue Xi Peng-Fei Xu 《World Journal of Gastroenterology》 SCIE CAS 2021年第45期7859-7861,共3页
Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells.Fasudil may be a promising clinical therapeutic drug for the prevention... Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells.Fasudil may be a promising clinical therapeutic drug for the prevention and treatment of liver fibrosis. 展开更多
关键词 Fasudil Liver fibrosis Natural killer cell Hepatic stellate cell Clinical therapeutic drug
暂未订购 下载PDF
Oscillation neuron based on a low-variability threshold switching device for high-performance neuromorphic computing 认领 引用 被引量：5
17
作者 Yujia Li Jianshi Tang +5 位作者 Bin Gao Xinyi Li Yue Xi Wanrong Zhang He Qian Huaqiang Wu 《Journal of Semiconductors》 EI CAS CSCD 2021年第6期64-69,共6页
Low-power and low-variability artificial neuronal devices are highly desired for high-performance neuromorphic computing.In this paper,an oscillation neuron based on a low-variability Ag nanodots(NDs)threshold switchi... Low-power and low-variability artificial neuronal devices are highly desired for high-performance neuromorphic computing.In this paper,an oscillation neuron based on a low-variability Ag nanodots(NDs)threshold switching(TS)device with low operation voltage,large on/off ratio and high uniformity is presented.Measurement results indicate that this neuron demonstrates self-oscillation behavior under applied voltages as low as 1 V.The oscillation frequency increases with the applied voltage pulse amplitude and decreases with the load resistance.It can then be used to evaluate the resistive random-access memory(RRAM)synaptic weights accurately when the oscillation neuron is connected to the output of the RRAM crossbar array for neuromorphic computing.Meanwhile,simulation results show that a large RRAM crossbar array(>128×128)can be supported by our oscillation neuron owing to the high on/off ratio(>108)of Ag NDs TS device.Moreover,the high uniformity of the Ag NDs TS device helps improve the distribution of the output frequency and suppress the degradation of neural network recognition accuracy(<1%).Therefore,the developed oscillation neuron based on the Ag NDs TS device shows great potential for future neuromorphic computing applications. 展开更多
关键词 threshold switching Ag nanodots oscillation neuron neuromorphic computing
暂未订购 下载PDF
血液肿瘤患者社会支持水平与精神应对能力的相关性研究 认领 引用 被引量：2
18
作者 岳溪 陈莉 《中国社会医学杂志》 2025年第1期89-92,共4页
目的探讨血液肿瘤患者精神应对能力与社会支持水平的相关性。方法选取2018年1月-2023年6月在四川大学华西医院治疗的血液肿瘤患者510例,运用精神应对态度量表和社会支持评定量表评估患者精神应对能力和社会支持水平,分析不同临床特征患... 目的探讨血液肿瘤患者精神应对能力与社会支持水平的相关性。方法选取2018年1月-2023年6月在四川大学华西医院治疗的血液肿瘤患者510例,运用精神应对态度量表和社会支持评定量表评估患者精神应对能力和社会支持水平,分析不同临床特征患者精神应对能力和社会支持水平差异。结果患者精神应对能力平均得分(22.91±7.50)分;社会支持平均得分(61.82±8.82)分;不同年龄、婚姻状况、学历及宗教信仰的患者精神应对能力得分比较差异有统计学意义(P0.05)。结论血液肿瘤患者精神应对能力、社会支持水平受年龄、婚姻状况等因素的影响,同时精神应对能力与社会支持水平存在正相关关系。 展开更多
关键词 血液肿瘤 精神应对能力 社会支持水平 相关性
暂未订购 下载PDF
The Three Main SCFAs Inhibit the Inflammatory Response of A549 Cells Induced by Acinetobacter baumannii 认领 引用
19
作者 Shixiang Fu Yue Xi +5 位作者 Longkun Ding Man Yan Chang Sun Jun Zhao Yudong Jiao Liang Wu 《Journal of Biosciences and Medicines》 2022年第4期114-125,共12页
Objective: The objective is to explore the mechanism of inhibitory effect of three main SCFAs (acetate, propionate and butyrate) on inflammatory response of A549 cells. Methods: Human lung adenocarcinoma cells (A549 c... Objective: The objective is to explore the mechanism of inhibitory effect of three main SCFAs (acetate, propionate and butyrate) on inflammatory response of A549 cells. Methods: Human lung adenocarcinoma cells (A549 cells) were cultured, and were divided into normal control group (NC group), A. baumannii infection group (A. baumannii group), NF-κB inhibitor group (JSH group), A. baumannii infection + sodium acetate group (NaAc group), A. baumannii infection + sodium propionate group (NaPc group) and A. baumannii infection + sodium butyrate group (NaB group). Real-time quantitative PCR was used to detect the mRNA expression of NLRP3, Caspase-1, IL-1β, IL-6, and TGF-β in A549 cells. Western blotting assay was used to determine the expression of autophagy and “pyroptosis” related proteins of NRLP3, cleaved-Caspase-1 (P20), GSDMD (P30), LC-3 and Beclin-1. At the same time, the expression of NF-κB p65 protein in nucleus and cytoplasm of A549 cells was detected. The level of reactive oxygen species in A549 cells was detected by flow cytometry. Results: Compared with A. baumannii group, the mRNA expression of NLRP3, IL-1β and IL-6 in NaAc group, NaPc group and NaB group decreased significantly, the mRNA expression of Caspase-1 in NaPc group and NaB group decreased significantly, only the mRNA expression of TGF-β in NaB group increased significantly;LC3-II expression increased significantly in NaPc group and NaB group, only Beclin-1 expression increased and GSDMD (p30) expression decreased significantly in NaB group. All three kinds of SCFAs could significantly inhibit the expression of cleaved-Caspase-1 (p20) after A. baumannii infection, but there was no significant change in the protein expression of NLRP3. Compared with NC group, the production of reactive oxygen species in A. baumannii group increased significantly at 3 h after A. baumannii infection. Compared with A. baumannii group, NaB could significantly suppress the production of reactive oxygen species induced by A. baumannii. Compared with A. baumannii group, the expression of NF-κB p65 in nucleus was significantly decreased and the expression of NF-κB p65 in cytoplasm was significantly increased after 24 h pre-incubation with NaB, NaPc and NaAc, respectively. Conclusion: A. baumannii can induce inflammatory injury of pulmonary epithelial cells, and the three major SCFAs can inhibit the activation of NLRP3 inflammasome and the release of pro-inflammatory factors through NF-κB/ROS/NLRP3 pathway, which provides a new way for clinical prevention of severe inflammatory injury caused by A. baumannii infection. 展开更多
关键词 Acinetobacter baumannii SCFAs A549 Cells Inflammatory Injury
暂未订购 下载PDF
某焦化场地非均质包气带中多环芳烃(PAHs)来源及垂向分布特征 认领 引用 被引量：18
20
作者 孟祥帅 吴萌萌 +2 位作者 陈鸿汉 岳希 陶抒远 《环境科学》 EI CAS CSCD 北大核心 2020年第1期377-384,共8页
利用某废弃焦化场地内6眼深层采样孔,样品最大采集深度9. 5~42 m不等,分析包气带剖面上16种PAHs分布特征、污染来源以及影响迁移的因素.结果表明,各钻孔ΣPAHs最大含量介于134. 79~11 266. 81 mg·kg-1之间,主要分布层位为地表以下1... 利用某废弃焦化场地内6眼深层采样孔,样品最大采集深度9. 5~42 m不等,分析包气带剖面上16种PAHs分布特征、污染来源以及影响迁移的因素.结果表明,各钻孔ΣPAHs最大含量介于134. 79~11 266. 81 mg·kg-1之间,主要分布层位为地表以下1~5 m,含量以低环(2+3环)为主,单体以萘含量最高.场地污染主要来自于煤的燃烧源.焦油、沥青及其深加工产物的污染对场地ΣPAHs含量起控制作用.包气带砂卵砾石层作为污染物良好的下渗通道,砂层透镜体通过吸附及截留作用成为PAHs的主要富集层.化产区排放或泄漏的各类油液通过混溶、竞争性吸附等作用增强了PAHs垂向迁移能力,并致使深部包气带受到污染.地表0~1 m土壤受人为扰动、降雨淋滤、降解作用,30 m以下岩层受到地下水溶滤作用,导致低环/高环比例随深度增加呈现先升高后降低的趋势.污染来源、包气带理化指标及水文地质条件等共同作用控制PAHs垂向分布及迁移. 展开更多
关键词 包气带 非均质 多环芳烃(PAHs) 垂向分布 源解析
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 3 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈