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Mechanism of action of Xipayimaizibizi oral liquid on outlet obstruction-induced overactive bladder:An integrated study 认领 引用
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作者 Menglu Wang Yang Yang +7 位作者 Yuhang Du Jiamei Xie Yige Zhao Yongcheng An Ziyi Shan Shenyujun Wang Meng Hao Baosheng Zhao 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第1期86-99,共14页
Objective:To observe the effect of Xipayimaizibizi oral liquid(XP)in an overactive bladder(OAB)experimental rat model and to explore its pharmacological mechanisms.Methods:Network pharmacology was used to explore the ... Objective:To observe the effect of Xipayimaizibizi oral liquid(XP)in an overactive bladder(OAB)experimental rat model and to explore its pharmacological mechanisms.Methods:Network pharmacology was used to explore the potential mechanisms of action of XP.The rats underwent bladder outlet obstruction surgery and were administered the corresponding drug concentrations by gavage for 4 weeks.The study observed the body weight,water intake,bladder and kidney indices(to evaluate their general status),urination behavior pattern(to observe frequency and urgency),and urodynamics(to measure bladder parameters).Hematoxylin and eosin and Masson's trichome staining were used to observe changes in the bladder structure.Enzyme-linked immunosorbent assay was used to measure the levels of nerve growth factor,brain-derived neurotrophic factor,and acetylcholine in the urine.The key targets involved in these mechanisms were validated using reverse transcription-quantitative polymerase chain reaction,immunohistochemistry,and western blot in vivo/vitro experiments.Result:Network pharmacological analysis predicted that XP may alleviate OAB by affecting the cholinergic synapse and calcium signaling pathways.XP treatment significantly reduced the bladder index,improved urine behavior and urodynamic parameters,decreased the neurotransmitters in urine,and reduced the thickness of the bladder wall and collagen ratio.These results indicate that XP can alleviate OAB symptoms and improve the bladder structure.In vivo/vitro experiments further demonstrated that XP can inhibit targets,such as muscarinic acetylcholine receptor 2,and participate in cholinergic synapses to further regulate the parasympathetic nervous system.It can also reduce the overexpression of Ca2+ caused by agonists,inhibit targets such as transient receptor potential vanilloid type 1,and participate in calcium signaling pathways to maintain Ca2+ homeostasis.Conclusion:These results suggest that XP inhibited bladder overactivity by maintaining Ca2+ homeostasis and regulating the parasympathetic nervous system. 展开更多
关键词 Xipayimaizibizi oral liquid Overactive bladder Partial bladder outlet obstruction Muscarinic receptor Cholinergic synapse Calcium signaling pathway
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A critical review on oxidation behavior of Co-based superalloys 认领 引用 被引量：10
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作者 Chenghao PEI Qingshuang MA +4 位作者 Qiuzhi GAO Yue YANG Yuhang DU Hailian ZHANG Huijun LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2025年第3期183-206,共24页
The novel Co-based superalloys are extensively used in gas-powered and jet engine turbines due to their excellent high-temperature performance, achieved by strengthening the L12-γ′ ordered phase. This review present... The novel Co-based superalloys are extensively used in gas-powered and jet engine turbines due to their excellent high-temperature performance, achieved by strengthening the L12-γ′ ordered phase. This review presents an overview of the research progress on oxidation behavior of Co-based superalloys, including oxidation kinetics, oxides morphology, the formation and spallation of oxide layers, and importantly, the synergistic effects of alloying elements on oxidation resistance—a critical area considering the complex interactions with multiple alloying elements. Additionally, this review compares the oxidation resistance of single crystal versus polycrystalline alloys. The effect of phase interface and dislocations on oxidation behavior is also discussed. While significant progress has been achieved, areas necessitating further investigation include optimizing alloy compositions for enhanced oxidation resistance and understanding the long-term stability of oxide layers. The future prospects for Co-based superalloys are promising as ongoing research aims to address the existing challenges and unlock new applications at even higher operating temperatures. 展开更多
关键词 Cobalt Superalloys Oxidation Alloying elements Microstructure Temperature
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Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy 认领 引用 被引量：2
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作者 Xiangrong Pan Xixi Hou +11 位作者 Yuhang Du Zhixin Pang Shiyang He Lan Wang Jianxue Yang Longfei Mao Jianhua Qin Haixia Wu Baozhong Liu Zhan Zhou Lufang Ma Chaoliang Tan 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第12期471-477,共7页
Two-dimensional(2D)metal-organic frameworks(MOFs)have emerged as promising photosensitizers in photodynamic therapy in recent years.In comparison to bulk MOFs,constructing 2D MOFs can increase the presence of active s... Two-dimensional(2D)metal-organic frameworks(MOFs)have emerged as promising photosensitizers in photodynamic therapy in recent years.In comparison to bulk MOFs,constructing 2D MOFs can increase the presence of active sites through increasing the surface area ratio.Herein,we report a simple solventmediated synthesis method for preparation of 2D porphyrin-based MOF(In-TCPP)nanosheets without the addition of any surfactants as an efficient photosensitizer for enhancing photodynamic antibacterial therapy.The accurate regulation of the morphology and size of 2D In-TCPP nanosheets can be achieved by varying the ratio of water to N,N-dimethylformamide solvent with the appropriate assistance of pyridine.The optimal synthesized 2D In-TCPP nanosheets exhibit a diameter of 70–120 nm and a thickness of 21.5–27.4 nm.Promisingly,2D In-TCPP nanosheets produce a higher amount of 1O2 when exposed to660 nm laser compared to the In-TCPP bulk,indicating that the smaller nanosheets possess more active sites for reactive oxygen species generation and can greatly improve the antibacterial photodynamic therapeutic effect.Both the in vitro and in vivo results prove that the In-TCPP nanosheets can be used as a photosensitizer for efficient photodynamic antibacterial therapy to kill S.aureus and promote wound healing. 展开更多
关键词 Two-dimensional nanosheets Metal-organic frameworks Photosensitizers Photodynamic therapy Antibacterial
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Deep learning-assisted grafting of amino acids onto natural products from plants to enhance antibacterial performance for amplifying economic value 认领 引用
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作者 Jianjun Ding Tao Jiang +7 位作者 Yulun Chen Qiwen Chen Shaofeng Yuan Yuhang Du Yuliang Cheng Yahui Guo Hang Yu Weirong Yao 《Food Bioscience》 SCIE 2026年第1期752-765,共14页
While the plant kingdom harbors numerous natural products,many exhibit insufficient antibacterial efficacy in their native state.Herein,strategic ester-bond grafting of amino acids substantially amplifies the antimicr... While the plant kingdom harbors numerous natural products,many exhibit insufficient antibacterial efficacy in their native state.Herein,strategic ester-bond grafting of amino acids substantially amplifies the antimicrobial activity of these underutilized natural compounds,with the resulting NP-g-Amino conjugates advantageously degrading into environmentally benign amino acids and natural products under ambient conditions.In this investigation,three Graft-QSCR models and three Graft-QSAR models were established utilizing distinct deep learning methodologies to predict both antibacterial potential and minimum inhibitory concentration(MIC)of NP-g-Amino conjugates,respectively.The Graft-QSCR1 and Graft-QSAR1 models developed using the Multi-Layer Perceptron(MLP)algorithm demonstrated excellent accuracy in predicting antibacterial potential(AUC=0.98,ACC=0.96)and optimal MIC prediction performance(R2=0.77,RMSE=0.37).The combined application of Graft-QSAR1 and Graft-QSCR1 models guided amino acid grafting on three plant-derived natural products(Diosgenin,Stigmasterol,Protopanaxadiol),enhancing antibacterial activity by 60-235-fold.Taking diosgenin from Chinese yam(Dioscorea)as an example,successful amino acid grafting yielded the Do-g-Amino conjugates,whose structures were confirmed via multiple advanced spectroscopic techniques(FTIR,HR-MS,1H NMR,and 13C NMR).Antibacterial assays revealed potent inhibitory effects of Do-g-Arg(MIC=64μg/mL)and Do-g-His(MIC=128μg/mL)against Staphylococcus aureus,while lactate dehydrogenase cytotoxicity assessments validated their exceptional biosafety profiles.The underlying antibacterial mechanisms were further elucidated through scanning electron microscopy observations complemented by molecular simulations.This study not only establishes an innovative strategy for discovering novel antimicrobial agents but also illuminates promising opportunities for enhancing the economic valorization of plant-derived compounds. 展开更多
关键词 Antibacterial NP-G-amino Graft-QSAR Deep learning
铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗 认领 引用 被引量：3
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作者 何世央 储丹丹 +10 位作者 庞志鑫 杜雨航 王嘉怡 陈雨鸿 苏雨蒙 秦建华 潘湘蓉 周战 李景果 马录芳 谭超良 《物理化学学报》 SCIE CAS CSCD 北大核心 2025年第5期157-166,共10页
面对由病原微生物感染引发疾病所带来的紧迫挑战,开发新型且高效的抗菌策略已成为当务之急。尽管光动力治疗在抗菌治疗领域已得到广泛应用,但在精确调控光敏剂结构以实现高效光动力性能方面仍存在一定的挑战。本文中,我们将铂单原子(SAs... 面对由病原微生物感染引发疾病所带来的紧迫挑战,开发新型且高效的抗菌策略已成为当务之急。尽管光动力治疗在抗菌治疗领域已得到广泛应用,但在精确调控光敏剂结构以实现高效光动力性能方面仍存在一定的挑战。本文中,我们将铂单原子(SAs)锚定在二维(2D)Al-TCPP金属-有机框架(Pt/Al-TCPP)纳米片上,并将其用作光敏剂增强活性氧(ROS)的产生,实现高效的光动力抗菌治疗。通过将Pt SAs锚定到2D Al-TCPP纳米片上,我们不仅改善了Pt SAs的分散性和稳定性,还利用了MOF晶体多孔结构与Pt SAs之间的协同作用,优化了光子功能和光捕获能力。这种结构增强了Pt SAs与卟啉连接体之间的桥接单元,促进了光照下的高效电荷转移和分离,从而增强ROS的产生。同时,除了Pt SAs的固有光动力性能之外,它的存在还能增加氧气的吸附、加速电子转移、促进电荷分离,从而提高其光动力产生ROS的效率。因此,与Al-TCPP相比,Pt/Al-TCPP光敏剂在660 nm激光照射下显示出更高的ROS生成效率。体外和体内实验均表明,在激光照射下,较低剂量的Pt/Al-TCPP纳米片能够在较短时间内有效杀灭细菌并促进伤口愈合。本研究结果为抗菌策略的开发提供了新视角,并展示了Pt/Al-TCPP纳米片作为高效伤口愈合治疗剂的潜力。 展开更多
关键词 铂单原子 二维金属-有机框架材料 光动力治疗 抗菌 伤口愈合
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Thermal convection driven by a heat-releasing scalar component 认领 引用 被引量：1
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作者 Yuhang Du Mengqi Zhang Yantao Yang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2022年第10期56-65,共10页
In this paper,we investigate the thermal convection flow which is driven by a heat-releasing concentration field.Different from our previous work on the internally heated double diffusive convection(IHDDC),in the curr... In this paper,we investigate the thermal convection flow which is driven by a heat-releasing concentration field.Different from our previous work on the internally heated double diffusive convection(IHDDC),in the current internally heated Rayleigh-Bénard convection(IHRBC),the fluid density depends solely on the temperature field and the concentration field only serves as the internal heat source.Linear stability analyses reveal that the most unstable mode is always the stationary one.The critical Rayleigh number,which measures the strength of the unstable driving force,decreases with the Schmidt number(the ratio between the viscosity and the molecular diffusivity of concentration field),but increases with the Prandtl number(the ratio between the viscosity and the thermal molecular diffusivity).Fully developed flows are then studied by three-dimensional direct numerical simulations.The unifying model developed for IHDDC can also be used to describe the transport properties for the current flow.The characteristic widths are smaller for the plumes descending from the top plate than those ascending from the bottom one. 展开更多
关键词 Internally heated convection Direct numerical simulation
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Design and Implementation of a Network Performance Analysis System for Space Network Emulation Platforms 认领 引用
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作者 Dongxu Hou Fa Chen +6 位作者 Chengpeng Kuang Yuhang Du Qi Zhang Kanglian Zhao Wenfeng Li Sidan Du Yuan Fang 《China Communications》 SCIE CSCD 2022年第9期199-213,共15页
Emulation platforms are critical for evaluation and verification in the research of networking technologies and protocols for space networks(SN).High fidelity emulating technologies have been extensively studied for S... Emulation platforms are critical for evaluation and verification in the research of networking technologies and protocols for space networks(SN).High fidelity emulating technologies have been extensively studied for SN in earlier work,while little emphasis has been placed on the performance evaluation part.In this paper,the design of a network performance analysis architecture is presented,with which high-speed network traffic can be captured and indexed,and the performance of the emulated SN can be well analyzed and evaluated.This architecture comprises three components,namely capture layer,storage layer and analysis layer.Analytic Hierarchy Process(AHP)and several analysis methods are adopted to evaluate the network performance comprehensively.In the implementation of the proposed architecture,configuration optimization and parallel processing are applied to handle large amount of high-speed network traffic.Finally,experiment results through the analysis system exhibits the effectiveness of the proposed architecture. 展开更多
关键词 space networks emulation platforms network performance analysis
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Protein corona formation as a strategy for achieving SERS detection of orlistat and phenobarbital 认领 引用 被引量：1
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作者 Shuna Mi Yuhang Du +4 位作者 Shaofeng Yuan Hang Yu Yahui Guo Yuliang Cheng Weirong Yao 《Food Bioscience》 SCIE 2025年第10期403-411,共9页
Achieving sensitive Surface enhanced Raman scattering(SERS)detection of targets with weak SERS signals remains a major challenge in the application of SERS technology for food safety analysis.In this study,the formati... Achieving sensitive Surface enhanced Raman scattering(SERS)detection of targets with weak SERS signals remains a major challenge in the application of SERS technology for food safety analysis.In this study,the formation of protein corona on nanoparticles and the interaction between the target and protein were utilized to synthesize Au@BSA and Au@LA as SERS substrates for detecting orlistat and phenobarbital,which possess weak signals.The feasibility of this method was validated using molecular docking and fluorescence spectroscopy.Acting as an intermediary,the protein corona anchors free target molecules in close proximity to the gold nanoparticle surface,thereby modulating their otherwise weak interactions with the SERS substrate and resulting in a pronounced enhancement of the SERS signal.Consequently,the linear ranges for orlistat and phenobarbital were 0.5-40 mg/L and 1-100 mg/L,respectively,with recovery rates ranging from 90.31%to 100.30%.In real food and Chinese patent medicine samples,the detection results were consistent with those obtained by high performance liquid chromatography(HPLC),demonstrating the strong potential of this method for practical applications in food safety monitoring.This study developed a simple,cost-effective,and more suitable SERS method for on-site detection,and provides a novel approach for SERS detection of targets with weak affinity to substrate. 展开更多
关键词 SERS Orlistat Phenobarbital Protein corona Interaction
Stress-informed transfer learning:Accelerated battery life evaluation model across diverse operating conditions and cell mechanisms 认领 引用
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作者 Guangyuan Zeng Yuhang Du +2 位作者 Yuchen Song Datong Liu Yu Peng 《Energy and AI》 EI CSCD 2025年第4期383-397,共15页
Life evaluation for newly developed lithium-ion batteries is often constrained by the time-intensive and costly nature of battery testing.This is particularly true in the aerospace industry,where limited comprehensive... Life evaluation for newly developed lithium-ion batteries is often constrained by the time-intensive and costly nature of battery testing.This is particularly true in the aerospace industry,where limited comprehensive data availability significantly hampers life evaluations.Data collected from batteries under diverse operating con-ditions and cell mechanisms provides valuable insights for constructing degradation models.Nevertheless,the nonlinearity in battery degradation across operating conditions,combined with data distribution discrepancies among different cell mechanisms,presents significant challenges in developing degradation models for newly designed batteries.In this study,a stress-informed transfer learning methodology is proposed to accelerate the life evaluation process.Firstly,a stochastic model is employed to capture the nonlinear dynamics inherent in battery degradation under diverse operating conditions.Model migration is implemented to adapt stochastic models to unique degradation trends,ensuring precision under varying stresses.Secondly,a Transformer-based model is developed to accommodate variations in data distributions across different cell mechanisms.Domain-adaptive fine-tuning with specified loss function is then incorporated to address the challenge of limited target degradation features.Finally,a hybrid model is devised by integrating these foundational components,realizing accelerated life evaluation through the utilization of multi-modal data.Experimental results demonstrate that the proposed methodology achieves improvements of 63.40%in MAE and 58.55%in RMSE with 30%training data length compared to mainstream benchmark methods.This highlights the method’s potential as an early-stage screening and assessment tool for newly developed space lithium-ion batteries,complementing conventional cycle life evaluation protocols with accelerated evaluations from limited degradation data. 展开更多
关键词 Lithium-ion battery Accelerated life evaluation Transfer learning Stochastic model Transformer network,Model fusion
Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity 认领 引用 被引量：11
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作者 Teng Ye Zhengsheng Chen +8 位作者 Jieyuan Zhang Lei Luo Renzhi Gao Liangzhi Gong Yuhang Du Zongping Xie Bizeng Zhao Qing Li Yang Wang 《Bioactive Materials》 SCIE CSCD 2023年第3期194-208,共15页
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated... Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated in recent years.However,whether large extracellular vesicles(lEVs),another subset of extracellular vesicles,possesses the ability for the improvement of tendinopathy remains unknown.Here,we showed that lEVs secreted from iPSC-derived MSCs(iMSC-lEVs)significantly mitigated pain derived from tendinopathy in rats.Immuno-histochemical analysis showed that iMSC-lEVs regulated the heterogeneity of infiltrated macrophages and several inflammatory cytokines in rat tendon tissue.Meanwhile,in vitro experiments revealed that the M1 pro-inflammatory macrophages were repolarized towards M2 anti-inflammatory macrophages by iMSC-lEVs,and this effect was mediated by regulating p38 MAPK pathway.Moreover,liquid chromatography-tandem mass spectrometry analysis identified 2208 proteins encapsulated in iMSC-lEVs,including 134 new-found proteins beyond current Vesiclepedia database.By bioinformatics and Western blot analyses,we showed that DUSP2 and DUSP3,the negative regulator of p38 phosphorylation,were enriched in iMSC-lEVs and could be transported to macrophages.Further,the immunomodulatory effect of iMSC-lEVs on macrophages was validated in explant tendon tissue from tendinopathy patients.Taken together,our results demonstrate that iMSC-lEVs could reduce inflammation in tendinopathy by regulating macrophage heterogeneity,which is mediated via the p38 MAPK pathway by delivery of DUSP2 and DUSP3,and might be a promising candidate for tendinopathy therapy. 展开更多
关键词 Large extracellular vesicles iPSC-derived MSCs Tendinopathy Inflammatory regulation Macrophages
Wearable Fiber‑Based Supercapacitors Enabled by Additive‑Free Aqueous MXene Inks for Self‑Powering Healthcare Sensors 认领 引用 被引量：6
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作者 Junlin Ma Zewei Cui +4 位作者 Yuhang Du Jianxin Zhang Changkai Sun Chengyi Hou Nan Zhu 《Advanced Fiber Materials》 SCIE EI CAS 2022年第6期1535-1544,共10页
Wearable fiber-based electronics have found diverse applications including energy storage,healthcare or thermal management,etc.In particular,additive-free aqueous inks play significant roles in fabrication of wearable... Wearable fiber-based electronics have found diverse applications including energy storage,healthcare or thermal management,etc.In particular,additive-free aqueous inks play significant roles in fabrication of wearable fiber-based devices,owning to their nontoxic nature and ease of manufacturing.Herein,wearable carbon fiber-based asymmetric supercapacitors(WASSC)are developed based on additive-free aqueous MXene inks,for self-powering healthcare sensors.The sediments of MXene without further modification are used as inks.Furthermore,combined with additive-free aqueous MXene/polyaniline(MP)inks,WASSC,with a wide voltage window and high capacitance is developed for practical energy supply.Impressively,WASSC has been successfully utilized to power wearable pressure sensors that could monitor motions and pulse signals.This wearable self-powered monitoring system on can accurately monitor the human motions,pronunciation,swallow or wrist pulse,without using the rigid batteries.This advantage realizes a great potential in simple and cost effective monitoring of human health and activities.Besides,self-powered system enables waste recycling of MXene and provides an effective approach for designing wearable and fiber-based self-powered sensors. 展开更多
关键词 Wearable electronics Additive-free aqueous inks Fiber-based supercapacitors MXene Self-powered sensor
Synergistic inhibition effect of anisaldehyde and cinnamaldehyde(SAC)against Aspergillus species(A.flavus&A.niger)in vitro and on bread 认领 引用 被引量：6
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作者 Muhammad Umair Khalid Hsu Mon Phyo +5 位作者 Yuhang Du Khubaib Ali Waqas Ashraf Hang Yu Imad Khan Weirong Yao 《Food Bioscience》 SCIE 2024年第5期1985-1998,共14页
To delay the spoilage of bread and reduce higher costs associated with using plant-derived compounds as natural bacteriostatic agents,synergistic antifungal effects were studied against the main bread spoilage fungi,A... To delay the spoilage of bread and reduce higher costs associated with using plant-derived compounds as natural bacteriostatic agents,synergistic antifungal effects were studied against the main bread spoilage fungi,Aspergillus niger and Aspergillus flavus.Among six combinations tested using a checkerboard method with four natural agents,only one combination of anisaldehyde and cinnamaldehyde(SAC)exhibits synergistic antifungal effects against both fungi.The combined minimum inhibitory concentration of SAC decreased to 75%compared to the individual minimum inhibitory concentration of both essential oil’s component.SAC inhibits spore germination by up to 99%and 98%against both fungi,respectively,at 2 MIC.At this concentration,SAC completely inhibits the mycelium growth of both fungi,resulting in severe morphological alternations observed via SEM.Moreover,SAC disrupts cell membrane integrity by increasing permeability,intracellular leakage,fluidity,and saturated fatty acid content.It also reduces intracellular protein concentration and ergosterol content,affecting cell membrane composition.SAC also disrupted energy metabolism by decreasing ATP concentration and ATPase activity.Additionally,SAC decreases the activity of chitin synthase and Beta 1,3-glucan synthase,compromising cell wall integrity.In vivo application of SAC at 2 MIC significantly increased the shelf life of bread by 15 days,demonstrating its potential as a natural additive against bread spoilage caused by A.flavus and A.niger. 展开更多
关键词 Synergistic effect Bacteriostatic agent Bread preservation Aspergillus species
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