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Expert consensus on the detection and clinical application of tumor mutational burden 认领 引用
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作者 Zhenying Guo Chunwei Xu +168 位作者 Shirong Zhang Yue Hao Xiaotong Hu Ming Zhao Chan Xiang Yingshi Piao Pingli Sun Xueping Xiang Jing Zhao Huanwen Wu Weixing Li Jinpu Yu Jingping Yuan Shuangshuang Wang Cong Wang Yun Gu Bingjian Lv Liping Zhang Yueping Liu Xiaobin Cui Weizhong Gu Yining Li Wei Wang Wenjun Yang Weiguo Long Jingjing Xiang Hong Mou Biao Liu Huajuan Ruan Yubin Wang Yongjie Zhu Feng Wang Zhonghua Wang Xiaomin Feng Xing Liu Peng Li Min Deng Bin Lian Lili Mao Qian Wang Wenxian Wang Zhengbo Song Ziming Li Wenzhao Zhong Zhijie Wang Shengxiang Ren Wenfeng Fang Yongchang Zhang Jingjing Liu Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Yu Chen Yu Zhang Feng Wang Zhansheng Jiang Gen Lin Long Huang Xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Dongqing Lv Zongyang Yu Peng Shen Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping Zhang Junli Xue Hui Guo Qian Chu Rui Meng Jingxun Wu Rui Zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Rui Ge Enyong Dai Yu Han Jian Zhang Yinghua Ji Xianbin Liang Hongmei Zhang Xuelei Ma Xuewen Liu Yu Yao Peng Luo Weiwei Pan Fei Pang Fan Wu Dejian Gu Li Wang Liping Wang Youcai Zhu Li Lin Weiwen Li Xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei Huijing Feng Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Yinbin Zhang Binbin Song Wenfeng Li Jianfei Fu Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Qing Ji Yuan Fang Qing Wei Zhen Wang Bin Wan Donglai Lv Xiaofeng Li Shengjie Yang Jing Kang Jiatao Zhang Chao Zhang Lin Shi Yina Wang Bihui Li Zhang Zhang Ke Wang Zhefeng Liu Nong Yang Lin Wu Xiaobing Chen Gu Jin Zhongwu Li Miao Li Guansong Wang Jiandong Wang Meiyu Fang Yong Fang Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Lu Si Yong Song Yuanzhi Lu Aijun Liu Yuchen Han 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第2期218-246,共29页
As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing o... As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms.However,the lack of uniformity in detection methods,threshold settings,and reporting formats,as well as the significant differences in TMB values among different cancer types,have hindered the standardized application of this biomarker in clinical practice.This consensus focuses on the definition,standardization of detection,clinical significance,and limitations of TMB,and provides consensus recommendations for the clinical application of TMB in real-world practice in China.This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB,promoting more accurate interpretation of test results,and improving patient care. 展开更多
关键词 Biomarkers tumor mutational burden tumor immunotherapy targeted panel sequencing whole-exome sequencing
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Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity 认领 引用 被引量：16
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作者 Zhi Yu Youbing Xia +4 位作者 Chuanhui Ju Qinghua Shao Zhen Mao Yun Gu Bin Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第9期809-816,共8页
The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations,... The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli （ST36）/ tnner Court （ST44） on the left side and Tianshu （ST25） bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanli/Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue. 展开更多
关键词 neural regeneration acupuncture and moxibustion electroacupuncture acupoint adipose tissue hypothalamus obesity feeding center acupuncture regeneration grants-supported paper neuroregeneration
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Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity 认领 引用 被引量：2
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作者 Bin Zhang Wenfeng Su +6 位作者 Junxia Hu Jinghui Xu Parizat Askar Shuangxi Bao Songlin Zhou Gang Chen Yun Gu 《Neuroscience Bulletin》 SCIE CAS CSCD 2022年第7期720-740,共21页
Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve function.While the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous syst... Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve function.While the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous system,the temporal dynamics and regulatory mechanisms that control the progress of the s lineage through myelination require further elucidation.Here,using in vitro co-culture models,gene expression profiling of laser capture-microdissected SCs at various stages of myelination,and multilevel bioinformatic analysis,we demonstrated that SCs exhibit three distinct transcriptional characteristics duringmyelination:the immature,promyelinating,and myelinating states.We showed that suppressor interacting 3a(Sin3A)and 16 other transcription factors and chromatin regulators play important roles in the progress of myelination.Sin3A knockdown in the sciatic nerve or specifically in SCs reduced or delayed the myelination of regenerating axons in a rat crushed sciatic nerve model,while overexpression of Sin3A greatly promoted the remyelination of axons.Further,in vitro experiments revealed that Sin3A silencing inhibited SC migration and differentiation at the promyelination stage and promoted SC proliferation at the immature stage.In addition,SC differentiation and maturation may be regulated by the Sin3A/histone deacetylase2(HDAC2)complex functionally cooperating with Sox10,as demonstrated by rescue assays.Together,these results complement the recent genome and proteome analyses of SCs during peripheral nerve myelin formation.The results also reveal a key role of Sin3A-dependent chromatin organization in promoting myelinogenic programs and SC differentiation to control peripheral myelination and repair.These findings may inform new treatments for enhancing remyelination and nerveregeneration. 展开更多
关键词 (Re)myelination Schwann cells Sin3A Transcriptome Peripheral nerve injury
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Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy 认领 引用 被引量：1
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作者 Rujun Wei Jiyun Long +10 位作者 Haoxue Xia Yanni Sun Lin Zhang Xiaoqing Li Hongping Zhang Run Wang Shengtao Gao Yunwei Chen Yun Gu Xiaoya Wang Jinfeng Wang 《Science China(Life Sciences)》 SCIE CSCD 2026年第6期1858-1870,共13页
Among the various pregnancy complications,gestational diabetes mellitus(GDM)is one of the most prevalent and damaging adverse conditions.GDM is characterised by dysregulated gut microbiota and dysglycaemia.There is a ... Among the various pregnancy complications,gestational diabetes mellitus(GDM)is one of the most prevalent and damaging adverse conditions.GDM is characterised by dysregulated gut microbiota and dysglycaemia.There is a keen search for active ingredients that can modify gut dysbiosis and glycaemic imbalances.In this study,the effects of dietary supplementation with high fibre and galacto-oligosaccharides(GOS)on GDM were evaluated.We found that GOS effectively alleviated blood glucose,hepatic inflammatory response,and lipid metabolism in high-fat-induced GDM mice.Furthermore,GOS redressed GDM-associated gut dysbiosis and altered glycerolipid metabolic pathways.GOS supplementation significantly downregulated the levels of fat synthesis genes and inflammatory factors in the liver and upregulated the expression of lipolytic catabolic genes(Cyp4a10).In dietary GOS supplementation,Lachnospiraceae bacteria strongly cooccurred with saturated lysophosphatidylcholine in the glycerolipid metabolic pathway.Metagenomic analyses illustrated that Lachnospiraceae bacteria-hostedα-galactosidase genes enriched upon GOS intake.GOS supplementation reduces lipopolysaccharide(LPS)entry into the systemic circulation by repairing intestinal mucosal damage,inhibits inflammatory cell production by reducing hepatic and intestinal Toll-like receptor-4(TLR-4)expression and potentially ameliorates blood glucose dysregulation in GDM by modulating glycerophospholipid metabolism.These results revealed that dietary supplementation of GOS during pregnancy may be a promising intervention against GDM. 展开更多
关键词 galacto-oligosaccharides Lachnospiraceae galactosidase gut microbiota lipid metabolism
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阿尔茨海默病药物治疗指南 认领 引用 被引量：20
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作者 刘雨辉 卜先乐 +28 位作者 马辛 王刚 王虹峥 王桂红 朱飞奇 乔立艳 刘肇瑞 纪勇 李小凤 李延峰 李霞 肖卫忠 肖世富 吴庆建 张巍 郁金泰 周玉颖 侯清华 袁俊亮 贾建军 顾耘 郭玲 郭起浩 彭丹涛 裴中 潘伟刚 王延江 王军 阿尔茨海默病防治协会 《阿尔茨海默病及相关病杂志》 2025年第1期8-16,共9页
基于现有文献证据和专家组讨论意见,在既往痴呆与认知障碍诊治相关指南基础上,对AD药物治疗方案和推荐意见进行了更新,重点引入抗Aβ免疫治疗相关进展,为AD的早期和全面干预提供参考。内容涵盖了阿尔茨海默病治疗原则,对症治疗药物中的... 基于现有文献证据和专家组讨论意见,在既往痴呆与认知障碍诊治相关指南基础上,对AD药物治疗方案和推荐意见进行了更新,重点引入抗Aβ免疫治疗相关进展,为AD的早期和全面干预提供参考。内容涵盖了阿尔茨海默病治疗原则,对症治疗药物中的胆碱酯酶抑制剂、兴奋性氨基酸受体拮抗剂、精神行为症状的药物治疗方法,Aducanumab、Lecanemab和Donanemab疾病修饰治疗,甘露特纳的使用,以及中医药物治疗原则和方法。 展开更多
关键词 阿尔茨海默病 药物治疗 淀粉样蛋白β 免疫治疗 指南
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Spatiotemporal Dynamics of the Molecular Expression Pattern 认领 引用 被引量：16
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作者 Leilei Gong Yun Gu +12 位作者 Xiaoxiao Han Chengcheng Luan Chang Liu Xinghui Wang Yufeng Sun Mengru Zheng Mengya Fang Shuhai Yang Lai Xu Hualin Sun Bin Yu Xiaosong Gu Songlin Zhou 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第2期213-244,共32页
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits or promotes regeneration.Rec... Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits or promotes regeneration.Recent technological advances in spatial transcriptomics(ST)provide a unique opportunity to decipher most genes systematically throughout scar formation,which remains poorly understood.Here,we frst constructed the tissue-wide gene expression patterns of mouse spinal cords over the course of scar formation using ST after spinal cord injury from 32 samples.Locally,we profled gene expression gradients from the leading edge to the core of the scar areas to further understand the scar microenvironment,such as neurotransmitter disorders,activation of the pro-infammatory response,neurotoxic saturated lipids,angiogenesis,obstructed axon extension,and extracellular structure re-organization.In addition,we described 21 cell transcriptional states during scar formation and delineated the origins,functional diversity,and possible trajectories of subpopulations of fbroblasts,glia,and immune cells.Specifcally,we found some regulators in special cell types,such as Thbs1 and Col1a2 in macrophages,CD36 and Postn in fbroblasts,Plxnb2 and Nxpe3 in microglia,Clu in astrocytes,and CD74 in oligodendrocytes.Furthermore,salvianolic acid B,a blood–brain barrier permeation and CD36 inhibitor,was administered after surgery and found to remedy fbrosis.Subsequently,we described the extent of the scar boundary and profled the bidirectional ligand-receptor interactions at the neighboring cluster boundary,contributing to maintain scar architecture during gliosis and fbrosis,and found that GPR37L1_PSAP,and GPR37_PSAP were the most signifcant gene-pairs among microglia,fbroblasts,and astrocytes.Last,we quantifed the fraction of scar-resident cells and proposed four possible phases of scar formation:macrophage infltration,proliferation and diferentiation of scar-resident cells,scar emergence,and scar stationary.Together,these profles delineated the spatial heterogeneity of the scar,confrmed the previous concepts about scar architecture,provided some new clues for scar formation,and served as a valuable resource for the treatment of central nervous system injury. 展开更多
关键词 Spinal cord injury Glial scar Spatial transcriptomics Microenvironment Therapeutic strategy Salvianolic acid
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Rab27a/Slp2-a complex is involved in Schwann cell myelination 认领 引用 被引量：1
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作者 Wen-feng Su Yun Gu +5 位作者 Zhong-ya Wei Yun-tian Shen Zi-han Jin Ying Yuan Xiao-song Gu Gang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第11期1830-1838,共9页
Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were e... Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized. Our previous results demonstrated that a small GTPase Rab27a regulates lysosomal exocytosis and myelin protein trafficking in Schwann cells. In this present study, we established a dorsal root ganglion （DRG） neuron and Schwann cell co-culture model to identify the signals associated with Rab27a during myelination. First, Slp2-a, as the Rab27a effector, was endogenously expressed in Schwann cells. Second, Rab27a expression significantly increased during Schwann cell myelination. Finally, Rab27a and Slp2-a silencing in Schwann cells not only reduced myelin protein expression, but also impaired formation of myelin-like membranes in DRG neuron and Schwann cell co-cultures. Our findings suggest that the Rab27a/ Slp2-a complex affects Schwann cell myelination in vitro. 展开更多
关键词 nerve regeneration Schwann cells dorsal root ganglion neurons co-culture myelin proteins myelination Rab27 effectors Rab27a Slp2-a neural regeneration
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Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes 认领 引用 被引量：4
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作者 Yun-Tian Shen Yun Gu +4 位作者 Wen-Feng Su Jing-fei Zhong Zi-Han Jin Xiao-Song Gu Gang Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2016年第4期331-340,共10页
Myelination by oligodendrocytes in the central nervous system requires coordinated exocytosis and endocytosis of the major myelin protein, proteolipid protein （PLP）. Here, we demonstrated that a small GTPase, Rab27b... Myelination by oligodendrocytes in the central nervous system requires coordinated exocytosis and endocytosis of the major myelin protein, proteolipid protein （PLP）. Here, we demonstrated that a small GTPase, Rab27b, is involved in PLP trafficking in oligodendrocytes. We showed that PLP co-localized with Rab27b in late endosomes/lysosomes in oligodendrocytes. Short hairpin- mediated knockdown of Rab27b not only reduced lysosomal exocytosis but also greatly diminished the surface expression of PLP in oligodendrocytes. In addition, knockdown of Rab27b reduced the myelin-like membranes induced by co-culture of oligodendrocytes and neurons. Our data suggest that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/ lysosomes to the cell membrane in oligodendrocytes. 展开更多
关键词 Myelination Neuron-glial interaction Oligodendrocyte Lysosome Rab27b
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弗氏盐法废水除氯产物资源化及二次利用进展 认领 引用 被引量：3
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作者 顾云 储鹏 +7 位作者 葛冬冬 黄寿强 蒋敏 吕红映 张文欣 吕杨杨 吕扬 张雅珩 《过程工程学报》 CAS CSCD 北大核心 2024年第2期151-161,共11页
废水中高浓度氯离子不仅会腐蚀工业设备,还易污染水环境。目前,已报道了一系列去除废水中氯离子的技术,如膜分离或浓缩、蒸发结晶、化学沉淀、吸附、离子交换、电解、氧化和溶剂萃取等。化学沉淀法在设备投资和可操作性等方面具有较大... 废水中高浓度氯离子不仅会腐蚀工业设备,还易污染水环境。目前,已报道了一系列去除废水中氯离子的技术,如膜分离或浓缩、蒸发结晶、化学沉淀、吸附、离子交换、电解、氧化和溶剂萃取等。化学沉淀法在设备投资和可操作性等方面具有较大的优势,其中,相对于基于银、铜或铋等除氯方法,弗氏盐沉淀除氯法因所用原料来源广、价格低而得到广泛研究。但弗氏盐沉淀除氯后会产生大量的化学污泥,这些污泥主要含有弗雷德盐(3CaO·Al2O3·CaCl2·10H2O)、加藤石[Ca3Al2(OH)12]和氢氧化钙等,成分复杂,循环再生难。为使弗氏盐沉淀除氯法能够推广应用,对其除氯产物,特别是其中的弗雷德盐进行资源化再利用至关重要。本工作在介绍弗雷德盐成分结构特性的基础上,通过比较弗雷德盐不同制备方法,突出弗氏盐沉淀法(如超高石灰铝法和钙铝石法)既能去除氯离子又能得到弗雷德盐的优势。根据弗雷德盐含铝和钙成分和层状双金属氢氧化物结构特性,可进行有效的资源化利用,包括去除各类重金属阳离子(如Cu2+,Cd2+,Co2+,Zn2+,Pb2+)和含氧阴离子[如Sb(OH)6-,AsO43-,SeO42-,CrO42-],并制备聚合氯化铝混凝剂、作为污泥脱水调理剂等,这些用途都具有广阔的应用前景,为弗氏盐沉淀除氯法的进一步发展提供借鉴和探索方向。 展开更多
关键词 含氯废水 弗氏盐沉淀法 化学污泥 弗雷德盐 资源化再利用
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应用MAIA微视野计评估青光眼黄斑部功能改变 认领 引用 被引量：3
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作者 鞠宏 郝瑞 +1 位作者 顾韫 丁肇凤 《国际眼科杂志》 CAS 北大核心 2023年第12期1950-1953,共4页
目的:观察青光眼患者微视野特征,探讨微视野检测值与最佳矫正视力(BCVA)、标准自动视野检测指标和光学相干断层扫描(OCT)检测指标的相关性。方法:病例对照研究。纳入青光眼患者45例76眼,其中原发开角型青光眼15例25眼,慢性闭角型青光眼3... 目的:观察青光眼患者微视野特征,探讨微视野检测值与最佳矫正视力(BCVA)、标准自动视野检测指标和光学相干断层扫描(OCT)检测指标的相关性。方法:病例对照研究。纳入青光眼患者45例76眼,其中原发开角型青光眼15例25眼,慢性闭角型青光眼30例51眼;正常对照组40例76眼。所有受检眼进行了MAIA微视野、Humphrey视野、BCVA检测,并与OCT测量的结构指标进行相关性分析。结果:青光眼患者与正常人群相比,微视野测出的黄斑平均光敏感度(MS)、OCT测出的神经节细胞复合体(GCC)、神经纤维层(RNFL)厚度低于正常对照组,Humphrey视野计10-2程序测出的视野平均缺损(MD)、GCC局部丢失体积(FLV)、GCC整体丢失体积(GLV)、63%双曲线椭圆面积(BCEA)高于正常对照组。青光眼组MS与MD、FLV、GLV、BCVA(LogMAR)呈负相关(rs=-0.839、-0.665、-0.530、-0.424,均P<0.01)。青光眼组MS与GCC、RNFL呈正相关(rs=0.437、0.500,均P<0.01)。MAIA微视野计检测时间更短。ROC曲线分析表明微视野对青光眼的诊断准确度为中等。结论:MAIA微视野计敏感性高,能检测到OCT结构损伤区域的视网膜光敏感度降低。微视野检测值与BCVA、标准自动视野检测指标和OCT检测指标具有相关性,MAIA微视野计与OCT相结合能提高青光眼的早期诊断率。 展开更多
关键词 微视野 青光眼 黄斑 光学相干断层扫描(OCT)
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中国阿尔茨海默病早期预防指南(2024) 认领 引用 被引量：37
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作者 林璐 马辛 +28 位作者 王刚 王虹峥 王志群 王志稳 王晓明 王惠芳 朱飞奇 乔立艳 刘肇瑞 齐志刚 汤彬 李坤成 李朝辉 肖世富 郁金泰 周显波 赵禾欣 赵忙所 赵红彬 顾耘 郭红 郭玲 郭起浩 富丽萍 雷敏 潘伟刚 徐勇 王军 阿尔茨海默病防治协会 《阿尔茨海默病及相关病杂志》 2024年第3期168-175,共8页
阿尔茨海默病是一种病因复杂的严重智力致残疾病,目前尚无有效的治疗方法。我国是世界上老年人口最多、增长最快的国家之一,也是阿尔茨海默病发病率较高的国家。因此,如何早期预防阿尔茨海默病的发生,是现今健康领域最重要的课题之一。... 阿尔茨海默病是一种病因复杂的严重智力致残疾病,目前尚无有效的治疗方法。我国是世界上老年人口最多、增长最快的国家之一,也是阿尔茨海默病发病率较高的国家。因此,如何早期预防阿尔茨海默病的发生,是现今健康领域最重要的课题之一。我们在国内外相关研究的基础上,通过文献循证、干预研究实践、案例分析、经验总结和专家咨询,结合中国老年健康和社会文化特点,体现中国传统医学、武术、养生以及社区组织优势,制订出具有中国特色的阿尔茨海默病早期预防指南,涵盖了个人、家庭和社会三个层面的预防策略,从积极生活态度、社会活动参与、认知训练、体育锻炼、戒烟限酒、营养、睡眠,血压、血糖、血脂管理,体重和其他慢病管理以及中医开展针对阿尔茨海默病的一级预防。本指南仅供个人、家庭和社会开展阿尔茨海默病预防时参考。 展开更多
关键词 阿尔茨海默病 早期预防 指南
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从心主神明及肾生髓理论探讨林水淼治疗阿尔茨海默病经验 认领 引用 被引量：2
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作者 易希 潘露茜 +1 位作者 顾耘 赵彦超 《阿尔茨海默病及相关病杂志》 2022年第3期205-208,共4页
目的:报道上海市名中医林水淼教授治疗阿尔茨海默病(Alzheimer's disease,AD)医案一则,探讨林老辨治AD的临床经验。方法:对1例58岁的女性患者的临床资料、诊治经过进行分析。结果:林老认为AD属于神病范畴,重在从心肾论治,经中药治... 目的:报道上海市名中医林水淼教授治疗阿尔茨海默病(Alzheimer's disease,AD)医案一则,探讨林老辨治AD的临床经验。方法:对1例58岁的女性患者的临床资料、诊治经过进行分析。结果:林老认为AD属于神病范畴,重在从心肾论治,经中药治疗后患者认知功能明显改善,提高了日常生活能力。结论:以调心补肾为治则的中药治疗AD效果显著。 展开更多
关键词 名医经验 林水淼 阿尔茨海默病
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中医辨证论治阿尔茨海默病病案举隅 认领 引用 被引量：2
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作者 罗蔚 潘露茜 +1 位作者 顾耘 张涵瑜 《阿尔茨海默病及相关病杂志》 2022年第3期221-223,共3页
目的:报道1例中医有效辨证论治阿尔茨海默病(Alzheimer's disease,AD)病例,以期为AD的防治提供更多思路。方法:运用中医望、闻、问、切四诊技术及辨证论治治疗思路诊疗1例74岁女性AD伴发精神症状患者。结果:对于心气不足、肾精亏虚... 目的:报道1例中医有效辨证论治阿尔茨海默病(Alzheimer's disease,AD)病例,以期为AD的防治提供更多思路。方法:运用中医望、闻、问、切四诊技术及辨证论治治疗思路诊疗1例74岁女性AD伴发精神症状患者。结果:对于心气不足、肾精亏虚型AD患者采用调心补肾之治则效果显著;伴发精神症状AD患者“从痰论治”行之有效。结论:治病必求于本,正确运用中医药防治AD有效可行。 展开更多
关键词 阿尔茨海默病 中医临床 辨证论治
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Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications 认领 引用 被引量：15
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作者 Yan Jin Yixing Song +6 位作者 Jiaqi Lin Tianqing Liu Guicai Li Biqin Lai Yun Gu Gang Chen Lingyan Xing 《Burns & Trauma》 SCIE 2023年第1期62-71,共10页
Spinal cord injury(SCI)is an incurable trauma that frequently results in partial or complete loss of motor and sensory function.Massive neurons are damaged after the initial mechanical insult.Secondary injuries,which ... Spinal cord injury(SCI)is an incurable trauma that frequently results in partial or complete loss of motor and sensory function.Massive neurons are damaged after the initial mechanical insult.Secondary injuries,which are triggered by immunological and inflammatory responses,also result in neuronal loss and axon retraction.This results in defects in the neural circuit and a deficiency in the processing of information.Although inflammatory responses are necessary for spinal cord recovery,conflicting evidence of their contributions to specific biological processes have made it difficult to define the specific role of inflammation in SCI.This review summarizes our understanding of the complex role of inflammation in neural circuit events following SCI,such as cell death,axon regeneration and neural remodeling.We also review the drugs that regulate immune responses and inflammation in the treatment of SCI and discuss the roles of these drugs in the modulation of neural circuits.Finally,we provide evidence about the critical role of inflammation in facilitating spinal cord neural circuit regeneration in zebrafish,an animal model with robust regenerative capacity,to provide insights into the regeneration of the mammalian central nervous system. 展开更多
关键词 Inflammation Immune response Spinal cord injury Axon regeneration Cell death Zebrafish Inflammatory drugs Trauma Neurological damage
3D fracture modelling and limit state analysis of prestressed composite concrete pipes 认领 引用 被引量：1
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作者 Pengfei HE Yang SHEN +1 位作者 Yun GU Pangyong SHEN 《Frontiers of Structural and Civil Engineering》 SCIE EI CSCD 2019年第1期165-175,共11页
In this manuscript,we study fracture of prestressed cylindrical concrete pipes.Such concrete pipes play a major role in tunneling and underground engineering.The structure is modelled fully in 3D using three-dimension... In this manuscript,we study fracture of prestressed cylindrical concrete pipes.Such concrete pipes play a major role in tunneling and underground engineering.The structure is modelled fully in 3D using three-dimensional continuum elements for the concrete structure which beam elements are employed to model the reinforcement.This allows the method to capture important phenomena compared to a pure shell model of concrete.A continuous approach to fracture is chosen when concrete is subjected to compressive loading while a combined continuous-discrete fracture method is employed in tension.The model is validated through comparisons with experimental data. 展开更多
关键词 cylindrical concrete structures limit state analysis 3D fracture modelling prestressed composite pipes reinforced concrete three-point bending test
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Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect 认领 引用 被引量：4
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作者 Chengbin Xue Hui Zhu +19 位作者 Hongkui Wang Yaxian Wang Xi Xu Songlin Zhou Dong Liu Yahong Zhao Tianmei Qian Qi Guo Jin He Kairong Zhang Yun Gu Leilei Gong Jian Yang Sheng Yi Bin Yu Yongjun Wang Yan Liu Yumin Yang Fei Ding Xiaosong Gu 《Bioactive Materials》 SCIE CSCD 2024年第3期572-590,共19页
A central question in neural tissue engineering is how the tissue-engineered nerve(TEN)translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological processes.Her... A central question in neural tissue engineering is how the tissue-engineered nerve(TEN)translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological processes.Here,we report a skin-derived precursor-induced Schwann cell(SKP-SC)-mediated chitosan/silk fibroin-fabricated tissue-engineered nerve graft(SKP-SCs-TEN)that can promote sciatic nerve regeneration and functional restoration nearly to the levels achieved by autologous nerve grafts according to behavioral,histological,and electrophysiological evidence.For achieving better effect of neuroregeneration,this is the first time to jointly apply a dynamic perfusion bioreactor and the ascorbic acid to stimulate the SKP-SCs secretion of extracellular matrix(ECM).To overcome the limitation of traditional tissue-engineered nerve grafts,jointly utilizing SKP-SCs and their ECM components were motivated by the thought of prolongating the effect of support cells and their bioactive cues that promote peripheral nerve regeneration.To further explore the regulatory model of gene expression and the related molecular mechanisms involved in tissue engineering-aided peripheral nerve regeneration,we performed a cDNA microarray analysis of gene expression profiling,a comprehensive bioinformatics analysis and a validation study on the grafted segments and dorsal root ganglia tissues.A wealth of transcriptomic and bioinformatics data has revealed complex molecular networks and orchestrated functional regulation that may be responsible for the effects of SKP-SCs-TEN on promoting peripheral nerve regeneration.Our work provides new insights into transcriptomic features and patterns of molecular regulation in nerve functional recovery aided by SKP-SCs-TEN that sheds light on the broader possibilities for novel repair strategies of peripheral nerve injury. 展开更多
关键词 SKP-SCs-TEN Transcriptomic feature Reconstruction of regenerative microenvironment Molecular regulation Molecular regenerative-medicine
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