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Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes 认领 引用
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作者 Jianghao Feng Xing Liu +4 位作者 Hua Zhu Yun Yang Wei Liu Xiaoliang Jiang Zhiwei Yang 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第6期1202-1216,共15页
Background:The contribution of gut microbiota to the early stage of type 2 diabetes(T2D)remains incompletely understood.This study established a germ-free mouse model colonized with gut microbiota from donors with T2D... Background:The contribution of gut microbiota to the early stage of type 2 diabetes(T2D)remains incompletely understood.This study established a germ-free mouse model colonized with gut microbiota from donors with T2D to determine whether diabetes-associated microbiota could induce early diabetes-like phenotypes.Methods:Human fecal samples were collected from 18 healthy donors and 14 donors with T2D for microbiota profiling.Based on these features,samples from 12 healthy donors and 3 donors with T2D were selected,pooled within each group,and transplanted into germ-free mice,generating a healthy microbiota recipient group(HM,n=14)and a diabetes-associated microbiota recipient group(DM,n=13).Glucose homeostasis was assessed over 10 weeks using fasting blood glucose and intraperitoneal glucose tolerance tests.Gut microbial succession was analyzed by 16S rRNA sequencing.Fecal and plasma metabolomics were performed to identify metabolic and their associations with microbial changes.Results:DM mice developed an early diabetes-like phenotype characterized by progressive impairment of glucose tolerance,reduced insulin levels,and mild renal alterations,without sustained overt fasting hyperglycemia.Microbial divergence emerged before stable metabolic dysfunction and was accompanied by persistent dysbiosis in DM mice.Integrated metabolomic analysis identified coordinated alterations in fecal and plasma metabolites,with cholic acid and L-Dopa decreased in both compartments.L-Dopa showed consistent associations with altered genera,particularly Ruminococcus and Sellimonas.Conclusions:Transplanting diabetes-associated human gut microbiota effectively induced early glucose dysregulation in germ-free recipient mice.This model provides a framework for studying microbiota-associated events during early T2D-related metabolic deterioration. 展开更多
关键词 germ-free mice metabolomics microbiomics microbiota transplantation type 2 diabetes
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Selinexor-loaded polymeric micelle for multiple myeloma therapy 认领 引用
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作者 Peipei Yang Ying Qu +9 位作者 Bingyang Chu Wen Chen Xue Wei Meng Pan Mengyao Wang Yun Yang Qingya Liu Yuhuan Zheng Ting Niu Zhiyong Qian 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期536-541,共6页
Multiple myeloma(MM)is the second most common hematological malignancy and still remains incurable.Selinexor(SEL)is the first-in-class exportin 1(XPO1)inhibitor,and has demonstrated survival benefits in relapsedefract... Multiple myeloma(MM)is the second most common hematological malignancy and still remains incurable.Selinexor(SEL)is the first-in-class exportin 1(XPO1)inhibitor,and has demonstrated survival benefits in relapsedefractory MM patients.Despite its therapeutic potential,dose-limiting toxicities frequently compromise SEL's clinical utility and patients'quality of life.In this work,to improve therapeutic efficacy and minimize side effects of SEL,we designed the monomethyl poly(ethylene glycol)-poly(ε-caprolactone)(mPEG-PCL)micelle-encapsulated nanoformulation for MM therapy.The m PEG-PCL-SEL micelle exhibited controlled release behavior and showed remarkable cytotoxicity in MM cells.Most importantly,in the orthotopic MM model,this micelle system exhibited impressive therapeutic efficacy at low dosages and significantly prolonged the survival of MM-bearing mice.Moreover,the mPEG-PCL-SEL micelle demonstrated a favorable safety profile with fewer gastrointestinal and constitutional symptoms.And we found that compared with the free-SEL,the mPEG-PCL-SEL micelle maintained the integrity of the intestinal barrier,and was more beneficial to the diversity of the intestinal microbiota,which may be related to the improved gastrointestinal tolerability,making it an effective and safe choice for MM treatment. 展开更多
关键词 Multiple myeloma Selinexor Micelle Drug delivery Intestinalmicrobiota
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Developing a standardized procedure for SPE-enzyme-linked immunosorbent assay to provide high-quality quantification of ambient antibiotics 认领 引用
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作者 Yun Yang Lulu Li +7 位作者 Jinxin Wang Jiahao Ouyang Yu Quan Sijie Chen Chunzhao Chen Wei Ouyang Gang Yu Li Ling 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期670-676,共7页
The trade-off between quality and difficulty is a challenge when quantifying ambient antibiotics at trace levels.Compared with the precise yet complicate methods such as mass spectrometry(MS)techniques,the enzyme-link... The trade-off between quality and difficulty is a challenge when quantifying ambient antibiotics at trace levels.Compared with the precise yet complicate methods such as mass spectrometry(MS)techniques,the enzyme-linked immunosorbent assay(ELISA)offer a simple alternative.While some studies applied it on quantifying environmental pollutants,diverse optimization procedures were employed and matrix effects were not well-addressed.Here,the quantification capability of solid-phase extraction(SPE)coupled with ELISA on ambient antibiotics was evaluated using a newly developed standardized procedure.SPE-ELISA first underwent more rigorous optimization using an overall performance index and three-dimensional recovery response surface.A series of quantitative indicators including precision(relative standard deviation reached 0.3%),sensitivity(a minimal of 3.8 ng/L variation can be distinguished),limit of detection(0.3µg/L without pretreatment),and recoveries(>90%)of SPE-ELISA were achieved and the corresponding conditions were revealed.To eliminate matrix effects,the standard addition method was adopted.This approach,coupled with the linearization of the nonlinear calibration curve,yielded highly accurate(errors of 9%and 5.2%)and reliable(standard deviation of 0.49 and 0.61)results on measuring simulated surface and wastewaters with 5 ng/L and 10 ng/L sulfamethoxazole,which were highly comparable to those of MS methods(P>0.05).Overall,with more rigorous optimization and matrix effect eliminated,the standardized procedure in this study enabled SPE-ELISA to achieve high-quality quantification results.Considering the high throughputs,simple procedure,and low installation costs of SPE-ELISA,it could be a promising alternative for quantifying ambient antibiotics. 展开更多
关键词 Antibiotics ELISA Quantification Solid phase extraction Mass spectrometry
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Advanced interface engineering of Cu electrocatalysts to boost the electrocatalytic CO2reduction to multicarbon products 认领 引用
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作者 Yuanyi Yang Yun Yang +7 位作者 Diye Wei Yingxuan Zhu Zishan Han Yang Song Chunjin Wei Abdullah N.Alodhayb Xiaodong Yi Zhou Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第4期33-41,I0003,共9页
Electrocatalytic CO2reduction to multi‑carbon(C2+)products offers a promising route for sustainable fuel and chemical production,yet achieving high selectivity and activity under industrial current densities rem... Electrocatalytic CO2reduction to multi‑carbon(C2+)products offers a promising route for sustainable fuel and chemical production,yet achieving high selectivity and activity under industrial current densities remains a challenge.In this study,we first employed density functional theory(DFT)calculations to screen candidate Cu‑based catalysts and predicted that an Ag‑Cu2O interface would optimize the electronic structure,improve CO intermediate coverage,and lower the energy barrier for C‑C coupling.Subsequently,we engineered an Ag/Cu2O heterojunction catalyst via surface reconstruction and interfacial integration to enhance the activity and C2+selectivity of copper‑based catalysts in CO2RR.The preferred Ag/Cu2O‑2 heterojunction catalyst achieved a C2+Faradaic efficiency(FE)of 77.8%at‑300 mA cm‑2in a flow cell.Comprehensive in situ characterization and additional DFT calculations reveal that Ag‑Cu2O interfaces enhance CO adsorption,thereby promoting C‑C coupling and accelerating its subsequent proton‑coupled electron transfer(PCET).This synergy ultimately boosts C2+products formation over the Ag/Cu2O catalyst. 展开更多
关键词 Electrochemical CO2reduction reaction *CO coverage Interface engineering Heterojunction catalysts
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Impact of psychological nursing on anxiety,depression,wound healing,and satisfaction in patients with superficial basal cell carcinoma 认领 引用
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作者 Jin Zhu Yan-Hua Zhu Yun Yang 《World Journal of Psychiatry》 SCIE 2026年第2期45-55,共11页
BACKGROUND Superficial basal cell carcinoma(BCC)is a common skin cancer for which surgical treatment is currently the primary clinical approach.However,due to the large surgical incision,noticeable scarring can easily... BACKGROUND Superficial basal cell carcinoma(BCC)is a common skin cancer for which surgical treatment is currently the primary clinical approach.However,due to the large surgical incision,noticeable scarring can easily occur postoperatively,affecting the patient’s facial aesthetics.As such,providing appropriate nursing support during the perioperative period is essential.AIM To investigate the impact of psychological nursing on anxiety,depression,wound healing rates,and satisfaction in patients with superficial BCC.METHODS Clinical data from 87 patients with superficial facial BCC,who were treated at the Central Hospital of Enshi Prefecture Tujia and Miao Autonomous Prefecture between February 2023 and February 2025,were retrospectively analyzed.Patients were divided into 2 groups according to nursing method:Control(routine nursing,n=42);and intervention(psychological in addition to routine nursing,n=45).Anxiety and depression symptoms,wound healing rate,pain level,postoperative complications,quality of life,and satisfaction with nursing were compared between the groups.RESULTS After the nursing intervention,the study group exhibited significantly lower Hamilton Anxiety and Depression Scale scores than the control group(P<0.05).The wound healing rate in the intervention group(91.11%)was significantly higher than that in the control group(80.95%)(P<0.05),and the visual analog scale score was lower in the intervention group(P<0.05).The total incidence of complications in the intervention group(6.67%)was lower than that in the control group(19.05%)(P<0.05).Postoperative quality of life and satisfaction with nursing were higher in the intervention group(P<0.05).CONCLUSION Psychological nursing intervention(s)effectively alleviated negative emotions,promoted wound healing,reduced pain,improved satisfaction,and reduced postoperative complications in patients with superficial facial BCC. 展开更多
关键词 Anxiety Depression Satisfaction with nursing Psychological nursing Postoperative pain Superficial basal cell carcinoma
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焦化源颗粒物的理化性质及其对SO2非均相氧化反应的影响 认领 引用
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作者 李宏艳 任元春 +12 位作者 柳景炜 云洋 张卫东 付国 赵志新 王子语 高笑雨 崔阳 闫菊平 麻晓庆 项麦祺 张国忠 刘永春 《中国环境科学》 EI CAS CSCD 北大核心 2026年第8期4180-4190,共11页
以山西某焦化厂焦炉顶无组织排放颗粒物为对象,在进行形貌、化学组成和表面官能团分析的基础上,通过实验室老化过程模拟探究了SO2在焦化颗粒物表面硫酸盐的生成机制.结果显示,焦炉顶颗粒物呈现球状(22.6%)、棒状(13.9%)、絮状(10.7%... 以山西某焦化厂焦炉顶无组织排放颗粒物为对象,在进行形貌、化学组成和表面官能团分析的基础上,通过实验室老化过程模拟探究了SO2在焦化颗粒物表面硫酸盐的生成机制.结果显示,焦炉顶颗粒物呈现球状(22.6%)、棒状(13.9%)、絮状(10.7%)、不规则状(52.9%)四种形貌,整体含有丰富的EC1(58.3%)、OC4(13.6%)、NH4+(19.5%)、Ca(42.31%)、Fe(25.04%)等物质,表面以还原性有机碳(12%)、NH4+(19.5%)、SO42-(24.4%)等成分为主,以上理化特征与其它燃烧源排放颗粒存在一定的差异.该颗粒整体呈碱性,易于吸附环境空气中的水分和SO2,并在光照作用下生成O-H和C-H等活性官能团.当加入O2时,SO2可与这些官能团和O2发生反应,快速转化为硫酸盐,并生成具有生物毒性的羰基化合物. 展开更多
关键词 焦化源颗粒物 SO2 形貌特征 化学组成 老化机制
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Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3(CTRP3)in Human Diseases 认领 引用 被引量：2
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作者 Qing-peng Wang Chen Wang +4 位作者 Yan-hong Yuan Yun Yang Rui Tian Jiang-yang Chi Xin-zhong Chen 《Current Medical Science》 SCIE CAS CSCD 2025年第5期1023-1033,共11页
Adipokines,including C1qumor necrosis factor(TNF)-related proteins(CTRPs),adiponectin,TNF-α,and leptin,are crucial bioactive molecules that are secreted by adipose tissue and circulate in the bloodstream.To date,15 m... Adipokines,including C1qumor necrosis factor(TNF)-related proteins(CTRPs),adiponectin,TNF-α,and leptin,are crucial bioactive molecules that are secreted by adipose tissue and circulate in the bloodstream.To date,15 members of the CTRP family,which are collectively classified as part of the C1q/TNF superfamily,have been identified.Among these,CTRP3 stands out as a unique adipokine because of its distinct structural and functional properties.Recent research has highlighted the significant role of CTRP3 in the pathogenesis of various diseases.This review aims to comprehensively summarize the involvement and mechanisms of CTRP3 in the development of numerous disorders,as well as its potential therapeutic implications. 展开更多
关键词 C1q/TNF-related protein 3(CTRP3) Adipokine Metabolic disorders Cardiovascular disease Inflammation Fibrosis Therapeutic target Bone disease Tumor regulation Apoptosis
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Mutation in CmGhc1 confers the white hypocotyl phenotype in melon(Cucumis melo L.) 认领 引用 被引量：1
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作者 Yong Yang Rong Fan +8 位作者 Xuejun Zhang Meihua Li Yongbing Zhang Hongping Yi Manrui Ma Yun Yang Bin Liu Xingwang Liu Huazhong Ren 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第11期4242-4254,共13页
Melon is a globally cultivated horticultural crop with a predominantly hybrid commercial seed market in China.Seedling morphology,particularly hypocotyl color,is a valuable trait for rapid F1 hybrid seed purity assess... Melon is a globally cultivated horticultural crop with a predominantly hybrid commercial seed market in China.Seedling morphology,particularly hypocotyl color,is a valuable trait for rapid F1 hybrid seed purity assessment.While green hypocotyls are common,white hypocotyls are rare in melon germplasm.This study identified a mutant with white hypocotyl but green leaves from the heavy ion beam mutant library.Genetic analysis revealed that a single recessive gene controlled the white hypocotyl,designated CmGhc1.A single-base deletion in the fifth exon of CmGhc1 led to a truncated CmGhc1 lacking the HTH-MYB DNA binding domain,likely affecting its transcriptional activity.CmGhc1 was localized in the nucleus,and yeast two-hybrid analysis and a dual-LUC assay demonstrated it as a transcription repressor.Furthermore,a KASP marker(hc1)was developed and verified as a functional marker for breeding white hypocotyl germplasms in melon.RNA-seq data revealed that CmGhc1 significantly affected the transcription of genes related to chlorophyll metabolism and photosynthesis in hypocotyl.In summary,these findings contribute to our understanding of chloroplast biogenesis and provide a valuable tool for melon breeding. 展开更多
关键词 melon hypocotyl color fine mapping functional marker RNA-seq
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Rail profile optimization through balancing of wear and fatigue 认领 引用 被引量：1
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作者 Binjie XU Zhiyong SHI +2 位作者 Yun YANG Jianxi WANG Kaiyun WANG 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2025年第10期967-982,共16页
Rail profile optimization is a critical strategy for mitigating wear and extending service life.However,damage at the wheel-rail contact surface goes beyond simple rail wear,as it also involves fatigue phenomena.Focus... Rail profile optimization is a critical strategy for mitigating wear and extending service life.However,damage at the wheel-rail contact surface goes beyond simple rail wear,as it also involves fatigue phenomena.Focusing solely on wear and not addressing fatigue in profile optimization can lead to the propagation of rail cracks,the peeling of material off the rail,and even rail fractures.Therefore,we propose an optimization approach that balances rail wear and fatigue for heavy-haul railway rails to mitigate rail fatigue damage.Initially,we performed a field investigation to acquire essential data and understand the characteristics of track damage.Based on theory and measured data,a simulation model for wear and fatigue was then established.Subsequently,the control points of the rail profile according to cubic non-uniform rational B-spline(NURBS)theory were set as the research variables.The rail’s wear rate and fatigue crack propagation rate were adopted as the objective functions.A multi-objective,multi-variable,and multi-constraint nonlinear optimization model was then constructed,specifically using a Levenberg Marquardt-back propagation neural network as optimized by the particle swarm optimization algorithm(PSO-LM-BP neural network).Ultimately,optimal solutions from the model were identified using a chaos microvariation adaptive genetic algorithm,and the effectiveness of the optimization was validated using a dynamics model and a rail damage model. 展开更多
关键词 Heavy-haul railway Rail wear Rail fatigue Levenberg Marquardt-back propagation neural network as optimized by the particle swarm optimization algorithm(PSO-LM-BP neural network) Rail profile optimization Multi-objective optimization
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Nomogram for prediction of severe postoperative complications in elective hepato-pancreato-biliary surgery after COVID-19 breakthrough infection:A large multicenter study 认领 引用
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作者 Yun Yang Zheng Dang +6 位作者 Liang Tang Peng Lu Shang Ma Jin Hou Ze-Ya Pan Wan Yee Lau Wei-Ping Zhou 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第2期147-156,共10页
Background:Currently,there is a deficiency in a strong risk prediction framework for precisely evaluating the likelihood of severe postoperative complications in patients undergoing elective hepato-pancreatobiliary su... Background:Currently,there is a deficiency in a strong risk prediction framework for precisely evaluating the likelihood of severe postoperative complications in patients undergoing elective hepato-pancreatobiliary surgery subsequent to experiencing breakthrough infection of coronavirus disease 2019(COVID-19).This study aimed to find factors predicting postoperative complications and construct an innovative nomogram to pinpoint patients who were susceptible to developing severe complications following breakthrough infection of COVID-19 after undergoing elective hepato-pancreato-biliary surgery.Methods:This multicenter retrospective cohort study included consecutive patients who underwent elective hepato-pancreato-biliary surgeries between January 3 and April 1,2023 from four hospitals in China.All of these patients had experienced breakthrough infection of COVID-19 prior to their surgeries.Additionally,two groups of patients without preoperative COVID-19 infection were included as comparative controls.Surgical complications were meticulously documented and evaluated using the comprehensive complication index(CCI),which ranged from 0(uneventful course)to 100(death).A CCI value of 20.9 was identified as the threshold for defining severe complications.Results:Among 2636 patients who were included in this study,873 were included in the reference group I,941 in the reference group II,389 in the internal cohort,and 433 in the external validation cohort.Multivariate logistic regression analysis revealed that completing a full course of COVID-19 vaccination>6 months before surgery,undergoing surgery within 4 weeks of diagnosis of COVID-19 breakthrough infection,operation duration of 4 h or longer,cancer-related surgery,and major surgical procedures were significantly linked to a CCI>20.9.A nomogram model was constructed utilizing CCI>20.9 in the training cohort[area under the curve(AUC):0.919,95%confidence interval(CI):0.881–0.957],the internal validation cohort(AUC:0.910,95%CI:0.847–0.973),and the external validation cohort(AUC:0.841,95%CI:0.799–0.883).The calibration curve for the probability of CCI>20.9 demonstrated good agreement between the predictions made by the nomogram and the actual observations.Conclusions:The developed model holds significant potential in aiding clinicians with clinical decisionmaking and risk stratification for patients who have experienced breakthrough infection of COVID-19 prior to undergoing elective hepato-pancreato-biliary surgery. 展开更多
关键词 Nomogram Severe postoperative complications Hepato-pancreato-biliary surgery COVID-19 Breakthrough infection
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Awareness,Knowledge,and Acceptance of Living Wills Among Chinese Cancer Patients:A Cross‐Sectional Study 认领 引用
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作者 Longxia Hu Jiaqing Wang +16 位作者 Deying Hu Yilan Liu Yanhong Han Wenbin Liu Fen Teng Xiaoping Ding Yi Dai Lihong Bao Hongling Zhang Qingzhou Cheng Yun Yang Tingting Jiao Fei Luo Yali Yang Zixi Wang Xiaoping Yang Shengli Yang 《Health Care Science》 CSCD 2025年第5期319-327,共9页
Background:Given the suboptimal quality of end‐of‐life care among patients with cancer in China,promoting living wills is critical in this population.Living wills ensure that individuals can receive the medical care... Background:Given the suboptimal quality of end‐of‐life care among patients with cancer in China,promoting living wills is critical in this population.Living wills ensure that individuals can receive the medical care they desire during the terminal phase of an illness,maintain their dignity,and ultimately achieve a good death.However,current awareness and attitudes about living wills among Chinese patients with cancer remain unclear.We administered a questionnaire survey on living wills to patients with malignant tumors to assess their most important needs and increase understanding about living wills.Methods:In this cross‐sectional study using convenience sampling,inpatients with malignant tumors in Wuhan completed our questionnaire between July 2020 and June 2021.We collected patients'sociodemographic characteristics and details regarding their knowledge and attitudes about living wills.Results:Among 213 patients with malignant tumors,114(53.52%)had heard of living wills;125(58.69%)expressed their willingness to sign the“Five Wishes”living will document after learning about it through the questionnaire.Patients with malignant tumors had a high level of desire for the following living will items:the lives of family and friends return to normal as soon as possible after their death,maintaining personal hygiene and dignity,and remaining pain‐free.The knowledge level of patients with malignant tumors was related to their educational level(p<0.05)and self‐care ability(p<0.05).Conclusions:Patients with malignant tumors have a high need for comfort,cleanliness,and pain relief in the terminal stages.Patients with a higher level of education and those with poorer self‐care ability had greater knowledge and acceptance of living wills.Promotion can first be targeted toward more highly educated patients and can then be gradually expanded to other groups. 展开更多
关键词 attitude knowledge living will malignant tumor palliative care
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Correction:MiR-16-5p Plays an Inhibitory Role in Human Non-Small Cell Lung Cancer through Fermitin Family Member 2 认领 引用
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作者 Junqi Guo Yun Yang +6 位作者 Wei Zhao Zhonghai Yan Xia Yang Yunfei Yan Ruimin Hao Jinxia Hu Fei Jiao 《BIOCELL》 SCIE 2025年第9期1796-1796,共1页
Published:25 September 2025 In the article“MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2”(BIOCELL,2021,Vol.45,No.3,pp.627-638.doi:10.32604/biocell.2021.01349... Published:25 September 2025 In the article“MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2”(BIOCELL,2021,Vol.45,No.3,pp.627-638.doi:10.32604/biocell.2021.013496),there is an error in the Fig.3.In order to ensure the scientific and rigorous nature of our academic publications,we made a correction about Fig.3 correspondingly. 展开更多
关键词 fermitin family member non small cell lung cancer correction scientific rigor fermitin family member biocell vol no pp doi biocell there miR p
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等离子体金纳米双锥强局域电场促进共价有机框架光催化析氢研究 认领 引用
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作者 邓玉金 陈怡爽 +4 位作者 张礼杰 金辉乐 杨云 徐全龙 王舜 《物理化学学报》 SCIE CAS CSCD 北大核心 2026年第6期60-71,共12页
将等离子体金属纳米晶与半导体光催化材料复合是一种提升其光催化性能的有效策略。然而,由于局域表面等离子体共振(LSPR)效应复杂的物理化学行为,其活性增强机制仍不明确。本研究通过原位生长策略精确合成了具有强局域电场(LEF)的金纳... 将等离子体金属纳米晶与半导体光催化材料复合是一种提升其光催化性能的有效策略。然而,由于局域表面等离子体共振(LSPR)效应复杂的物理化学行为,其活性增强机制仍不明确。本研究通过原位生长策略精确合成了具有强局域电场(LEF)的金纳米双锥体(NBs),并将其封装在TpBD-COF中。实验表明,优化后的AuNBs/TpBD-COF复合材料表现出良好的光催化产氢性能,420 nm波长下的表观量子效率(AQE)达到0.58%。电磁场模拟和飞秒瞬态吸收光谱证实,强的局域电场有效促进了电荷分离激子的形成,从而为TpBD-COF产氢过程提供更多热载流子(高能电子/空穴对)。本研究工作为探究LSPR效应提升COF基光催化性能提供了深入见解。 展开更多
关键词 共价有机框架 局域表面等离子体共振 光催化产氢
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自噬参与系统性红斑狼疮发病的研究进展 认领 引用
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作者 聂婷婷 卜玉洁 +3 位作者 岑星 赵桂芳 云阳 陈俊伟 《中华临床免疫和变态反应杂志》 CAS 2026年第1期57-63,共7页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于育龄期女性,异质性强,致残率高,可产生多种抗体并累及多脏器的慢性自身免疫性疾病,SLE发病机制复杂,涉及遗传、环境和免疫学等诸多因素。自噬通过溶酶体降解自身受损胞质... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于育龄期女性,异质性强,致残率高,可产生多种抗体并累及多脏器的慢性自身免疫性疾病,SLE发病机制复杂,涉及遗传、环境和免疫学等诸多因素。自噬通过溶酶体降解自身受损胞质成分,控制细胞应激、蛋白质稳态和线粒体质量,其调节异常可导致细胞稳态破坏,引发多种疾病。自噬在维持固有免疫和适应性免疫稳态中发挥至关重要的作用。近年来,越来越多的研究证实,自噬参与了SLE发病基因易感性及免疫调节紊乱的诸多环节,免疫细胞自噬异常与SLE发病密切相关。因此,深入研究自噬对SLE免疫细胞分化及功能的影响,可为寻找SLE有效治疗靶点提供新思路。 展开更多
关键词 自噬 系统性红斑狼疮 免疫细胞
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A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial,antioxidant,and osteogenesis for periodontitis 认领 引用 被引量：1
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作者 Xicheng Li Dong Mo +14 位作者 Shoushan Hu Meng Pan Meng Wang Tingyu Yang Changxing Qu Yujia Wei Jianan Li Hanzhi Deng Zhongwu Bei Tianying Luo Qingya Liu Yun Yang Jun Liu Jun Wang Zhiyong Qian 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第9期451-457,共7页
Periodontitis is a chronic inflammatory disease caused by oral pathogens,and the osteogenic potential of human periodontal ligament stem cells(hPDLSCs)is severely impaired under the inflammatory environment.Current cl... Periodontitis is a chronic inflammatory disease caused by oral pathogens,and the osteogenic potential of human periodontal ligament stem cells(hPDLSCs)is severely impaired under the inflammatory environment.Current clinical periodontitis treatment strategies such as surgical interventions and antibiotic delivery still suffer from poor antibacterial efficacy,difficulty in ameliorating excessive inflammatory responses and slow periodontal tissue regeneration.Here,we have innovatively developed a non-surgical treatment strategy based on a functional composite hydrogel.A composite hydrogel system(Pt@ZIF-8/ALN-ac/Gel)containing bioactive zeolite imidazolate framework-8(ZIF-8)integrated with platinum nanoparticles(Pt@ZIF-8)and alendronate acrylamide(ALN-ac)was constructed on the basis of gelatin methacryloyl(GelMA)to achieve enhanced antibacterial effect and reactive oxygen species(ROS)scavenging ability while promoting the osteogenic potential of hPDLSCs.We confirmed that Pt@ZIF-8/ALN-ac/Gel was able to continuously release Zn2+and exerted an obvious antibacterial effect against Porphyromonas gingivalis.In vitro experiments proved that Pt@ZIF-8/ALN-ac/Gel had good biocompatibility,while efficiently featuring excellent reactive oxygen species(ROS)scavenging capacity,increasing alkaline phosphatase activity,and promoting extracellular matrix mineralization by hPDLSCs.In vivo,Pt@ZIF-8/ALN-ac/Gel significantly inhibited the alveolar bone deterioration and reduced osteoclast activation and inflammation,thereby promoting the regeneration of damaged tissues.These findings demonstrated superior therapeutic efficacy in the reported clinical periodontitis treatment,exhibiting great potential for application. 展开更多
关键词 ZIF-8 Reactive oxygen species Hydrogel Antibacterial Alendronate Periodontal regeneration
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Are impermeable curtains necessary for a groundwater contaminant remediation project? 认领 引用
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作者 Ming Guo Yun Yang +3 位作者 Qian-kun Luo Ying-chun Li Hai-chun Ma Jia-zhong Qian 《Journal of Groundwater Science and Engineering》 2025年第3期237-249,共13页
Constructing impermeable curtains to contain contaminant in aquifers is a costly and complex process that can impact the structure integrity of aquifer systems.Are impermeable curtains necessary for a groundwater cont... Constructing impermeable curtains to contain contaminant in aquifers is a costly and complex process that can impact the structure integrity of aquifer systems.Are impermeable curtains necessary for a groundwater contaminant remediation project?This study evaluates the necessity of impermeable curtains for groundwater contaminant remediation projects.Specifically,it considers remediation efforts based on the Pump and Treat(PAT)technique under various hydrogeological conditions and contaminant properties,comparing the total remediation cost and effectiveness.To further investigate,a multi-objective simulation and optimization model,utilizing the Multi-Objective Fast Harmony Search(MOFHS)algorithm,was employed to identify optimal groundwater remediation system designs that without impermeable curtains.Both a two-dimensional(2-D)hypothetical example and a three-dimensional(3-D)field example were used to assess the necessity of constructing impermeable curtains.The 2-D hypothetical example demonstrated that the installation of impermeable curtain is justified only when the dispersivity(αL)of the contaminant reaches 100 meters.In most cases,particularly at sites with porosity(n)under 0.3,alternative,more cost-effective,and efficient remediation strategies may be available,making impermeable barriers unnecessary.The optimization results of the 3-D field example further corroborate the conclusions derived from the 2-D hypothetical example.These findings provide valuable guidance for more scientifically informed,reasonable,and cost-effective groundwater contaminant remediation projects. 展开更多
关键词 Groundwater contaminant Hydrogeological condition Contaminant characteristics Impermeable curtains Simulation and optimization PAT
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Continuous treatment strategies improve psychological status and quality of life in patients with atopic dermatitis 认领 引用
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作者 Yi-Bo Meng Yao-Hui Ma +3 位作者 Yun Yang Dan-Dan Li Ren-Xiang Zhang Cui-Min Ren 《World Journal of Psychiatry》 SCIE 2025年第10期129-138,共10页
BACKGROUND Atopic dermatitis is a chronic inflammatory skin disease that poses a substantial burden on patients'physical health,as well as on their psychological health and quality of life.This study specifically ... BACKGROUND Atopic dermatitis is a chronic inflammatory skin disease that poses a substantial burden on patients'physical health,as well as on their psychological health and quality of life.This study specifically examines active disease phases(excluding spontaneous remission periods)to investigate the efficacy of continuous treatments on the psychological state and life quality of patients with atopic dermatitis.AIM To evaluate the effectiveness of continuous treatment strategies,including dermatological care,psychological counseling,education,and long-term follow-up,on the psychological state and quality of life in patients with atopic dermatitis.METHODS A retrospective cohort study was conducted on 120 atopic dermatitis patients treated at our hospital between June 2023 and May 2024.A total of 120 patients were randomly assigned into control and intervention groups(60 patients each).The control group underwent routine treatment,and the intervention group was treated using continuous treatment strategies,including personalized skin care plan,psychological counseling,patient education,and long-term follow-up.Quality of life and psychological status of patients were assessed using the dermatology life quality index and Hospital Anxiety and Depression Scale.RESULTS At 12 months post-intervention,the dermatology life quality index scores in the intervention group were significantly lower than those in the control group(P<0.01),implying improved quality of life.The anxiety and depression symptoms were significantly lower in the intervention group when compared to the control group(P<0.05)as per the Hospital Anxiety and Depression Scale.In the intervention group,the rate of recurrence of skin symptoms was 15%compared to 35%in the control group,with a statistically significant difference between the two groups.CONCLUSION Continuous treatment for atopic dermatitis patients greatly improve their psychological state and quality of life,enhance disease-free survival,and offer new trains of thought for clinical treatment.Personalized integrated management over a prolonged time is important to improve quality of life in such patients. 展开更多
关键词 Atopic dermatitis Continuous treatment Quality of life Mental health Retrospective study
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RGS4 in gastric cancer:A multifaceted regulator of focal-adhesionkinase-phosphatidyl-inositol-3-kinase-protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression 认领 引用
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作者 Yun Yang Wen-Ming Chen 《World Journal of Gastroenterology》 SCIE CAS 2025年第41期179-183,共5页
Chen et al demonstrated that regulator of G protein signaling(RGS)4 promotes gastric cancer(GC)progression by activating the focal adhesion kinase/phospha-tidyl-inositol-3-kinase/protein kinase B pathway and inducing ... Chen et al demonstrated that regulator of G protein signaling(RGS)4 promotes gastric cancer(GC)progression by activating the focal adhesion kinase/phospha-tidyl-inositol-3-kinase/protein kinase B pathway and inducing epithelial-mesen-chymal transition.Although their multilevel approach integrating clinical data,functional assays,and xenograft models demonstrated a key role for RGS4 in GC pathogenesis,several limitations should be considered.The mechanism of the RGS4-focal adhesion kinase interaction remains unclear,specifically whether it involves direct binding or intermediaries.The clinical analysis of 90 patients lacks stratification by GC subtypes or immune features,potentially limiting generaliz-ability.Furthermore,fully validating RGS4’s oncogenic role requires additional studies,including functional assays in chemotherapy-resistant and metastatic cell lines,metastasis models including orthotopic implantation and tail vein injection,and comparison with other RGS family members.Addressing these via targeted mechanistic studies and expanded clinical validation could strengthen RGS4’s po-tential as a therapeutic target in GC. 展开更多
关键词 RGS4 Focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B Epithelial-mesenchymal transition Gastric cancer Biomarker Preclinical model
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肺癌外周免疫评分的最新研究进展 认领 引用
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作者 许帆 罗斌 +3 位作者 田建辉 杨蕴 程振洋 刘佑俊 《中国肺癌杂志》 CAS CSCD 北大核心 2025年第5期379-384,共6页
肺癌是发病率和死亡率最高的恶性肿瘤,肿瘤原发灶-淋巴结-转移(tumor-node metastasis,TNM)分期在肺癌相关预测中逐渐显现局限性,亟待构建新型临床预测模型指导肺癌防治。近年来,外周免疫评分作为一种基于外周免疫相关参数的综合评估体... 肺癌是发病率和死亡率最高的恶性肿瘤,肿瘤原发灶-淋巴结-转移(tumor-node metastasis,TNM)分期在肺癌相关预测中逐渐显现局限性,亟待构建新型临床预测模型指导肺癌防治。近年来,外周免疫评分作为一种基于外周免疫相关参数的综合评估体系,在预测模型构建中的价值逐渐凸显。该评分通过量化外周免疫成分的数量及比例,可动态反映机体整体免疫功能状态及肿瘤微环境特征。本文系统总结了外周免疫评分在肺癌早期诊断、用药疗效预测、不良反应预警及预后评估中的最新研究进展,旨在挖掘其潜在的临床应用价值,为开发新型肺癌相关预测模型提供一定的思路与方向。 展开更多
关键词 肺肿瘤 免疫治疗 外周免疫评分 预测模型
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科技计划对港澳地区开放的实践与启示 认领 引用
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作者 宋雨奇 周小林 +4 位作者 王珺 许莹莹 刘浩 杨云 任孝平 《中国科学基金》 CSSCI CSCD 北大核心 2025年第5期844-852,共9页
科技计划对外开放可以有效引导全球智力资源自由流动,是实现高水平对外开放的重要途径。当前,我国科技计划对外开放的制度基础逐步健全,政策体系不断优化,但在实际操作层面仍存在较多“壁垒”。香港地区和澳门地区作为我国对外开放的重... 科技计划对外开放可以有效引导全球智力资源自由流动,是实现高水平对外开放的重要途径。当前,我国科技计划对外开放的制度基础逐步健全,政策体系不断优化,但在实际操作层面仍存在较多“壁垒”。香港地区和澳门地区作为我国对外开放的重要桥梁和窗口,拥有与国际接轨的科研体系和环境,科技计划对港澳开放的成功实践对于打通科技计划对外开放的“梗阻”有重要启示作用。本文系统梳理我国科技计划对港澳开放的法律法规、政策文件,总结凝练科技计划对港澳开放的实践进展,深入研究广东地区科技计划对港澳地区开放的典型案例,挖掘科研资金跨境拨付、项目评审、资金使用、知识产权、数据流动等方面的堵点和障碍并提出解决方案,为高水平推动科技计划对外开放提供参考。 展开更多
关键词 科技计划 对外开放 经费跨境 跨境拨付
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