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Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses 认领 引用
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作者 Chunxia Jiang Yunan Hu +2 位作者 Feng Zhang Mengsheng Qiu Xiaofeng Zhao 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第4期781-794,共14页
Although oligodendrocytes(OLs)are known to form the myelin sheath around neuronal axons for the saltatory conduction of action potentials,recent studies have suggested that OLs also modulate neuronal function and plas... Although oligodendrocytes(OLs)are known to form the myelin sheath around neuronal axons for the saltatory conduction of action potentials,recent studies have suggested that OLs also modulate neuronal function and plasticity.In the present study,we found that OL maturation deficiency in Myrf-CKO mice caused spontaneous epileptogenesis and resulted in death.To further investigate the association between OL development and epilepsy,we examined the Adamts4 KO mouse line,which has a mild OL differentiation phenotype in the hippocampus.As a result,the differentiation defect in the mutant hippocampus reduced the expression of myelin-associated glycoprotein and lessened its inhibition of the dephosphorylation of phosphorylated tropomyosin-related kinase B,which is associated with retarded adolescent hippocampal mossy fiber development and higher susceptibility to epileptogenesis in adulthood.More importantly,enhancing differentiation by orally administered clemastine rescues the defective mossy fiber development in the early postnatal period and attenuates epilepsy susceptibility in adults.Together,these results strongly suggest that an OL differentiation defect in the hippocampus may contribute to susceptibility to epilepsy in adults. 展开更多
关键词 Oligodendrocyte Diferentiation Myelinassociated glycoprotein Tropomyosin-related kinase B Epilepsy
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Adaptive Iterative Learning Control for a Class of Nonlinear Time-varying Systems with Unknown Delays and Input Dead-zone 认领 引用 被引量：8
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作者 Jianming Wei Yunan Hu Meimei Sun 《IEEE/CAA Journal of Automatica Sinica》 EI 2014年第3期302-314,共13页
This paper presents an adaptive iterative learning control(AILC) scheme for a class of nonlinear systems with unknown time-varying delays and unknown input dead-zone.A novel nonlinear form of dead-zone nonlinearity is... This paper presents an adaptive iterative learning control(AILC) scheme for a class of nonlinear systems with unknown time-varying delays and unknown input dead-zone.A novel nonlinear form of dead-zone nonlinearity is presented.The assumption of identical initial condition for iterative learning control(ILC) is removed by introducing boundary layer function.The uncertainties with time-varying delays are compensated for by using appropriate Lyapunov-Krasovskii functional and Young’s inequality.Radial basis function neural networks are used to model the time-varying uncertainties.The hyperbolic tangent function is employed to avoid the problem of singularity.According to the property of hyperbolic tangent function,the system output is proved to converge to a small neighborhood of the desired trajectory by constructing Lyapunov-like composite energy function(CEF) in two cases,while keeping all the closedloop signals bounded.Finally,a simulation example is presented to verify the effectiveness of the proposed approach. 展开更多
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Prebiotic β(1-4)galacto-oligosaccharides strengthen intestinal barrier integrity via mucus production and modulation of tight junction genes 认领 引用
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作者 Yunan Hu Anika Charlotte Rueppell +6 位作者 Nehal Devpura Rebecca Zasloff Jason W.Arnold Jeffrey Roach Scott T.Magness Jose M.Bruno-Bárcena M.Andrea Azcarate-Peril 《Food Bioscience》 SCIE 2026年第1期501-511,共11页
Preserving a functional intestinal barrier is crucial for overall host health,as increased permeability can lead to systemic pathologies,including a dysregulated immune system and increased susceptibility to infection... Preserving a functional intestinal barrier is crucial for overall host health,as increased permeability can lead to systemic pathologies,including a dysregulated immune system and increased susceptibility to infections.Pure β(1-4)galacto-oligosaccharides(GOS)and Type 2 LacNAc-enriched β(1-4)GOS(humanized GOS,hGOS)modulate the gut microbiome,increasing the abundance of beneficial microorganisms,including Bifidobacterium,Akkermansia,and Lactobacillus.In this study,we report that direct exposure of monolayers of human primary colonic cells toβ(1-4)GOS and β(1-4)hGOS enhances barrier integrity by significantly upregulating MUC2(2-5 fold)and tight junction genes(1.5-8 fold)(p<0.05).RNA sequencing revealed thatβ(1-4)GOS and β(1-4)hGOS activated the Aryl Hydrocarbon Receptor(AHR)pathway,with GOS specifically inducing CYP1A1(log2FC=3.57)and TIPARP,while hGOS enriched pathways related to apical junction integrity.This suggests that AHR activation may enhance gut barrier function,in part,by repressing IL-1β-mediated inflammation.These findings were validated in vivo in young and old C57BL/6 mice,where GOS and hGOS enhanced intestinal permeability by increasing the expression of Muc2 and promoting mucus production,resulting in a thicker mucus layer(GOS:95%CI 0.054-0.146;hGOS:95%CI 0.080-0.176).Tight junction integrity genes were also upregulated by the prebiotics in our study(two-way ANOVA,p<0.05).Our findings suggest that,beyond their modulation of the gut microbiome,GOS and hGOS enhance intestinal barrier function by directly inducing the expression of mucin and tight junction genes,likely through the AHR pathway.These results highlight the potential of prebiotic supple-mentation in improving gut barrier function and maintaining intestinal health. 展开更多
关键词 galacto oligosaccharides gut microbiomeincreasing gut microbiome intestinal barrier mucus production tight junction genes prebiotics dysregulated immune system
Adaptive repetitive learning control for trajectory-keeping of satellite formation flying 认领 引用 被引量：1
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作者 Yunan Hu Jianming Wei Meimei Sun 《Journal of Control and Decision》 EI 2014年第4期317-331,共15页
An adaptive repetitive control scheme is proposed for trajectory-keeping of satellite formation flying in the leader–follower mode which is described by Lawden equation.The system is parameterised by power series app... An adaptive repetitive control scheme is proposed for trajectory-keeping of satellite formation flying in the leader–follower mode which is described by Lawden equation.The system is parameterised by power series approximation and the unknown timevarying parameters are estimated by adaptive repetitive learning law.Through rigorous analysis by constructing a Lyapunov-like composite energy function(CEF),the stability of the closed-loop system is proved.Finally,a simulation example is provided to illustrate the effectiveness of the control algorithms proposed in this paper. 展开更多
关键词 satellite formation flying trajectory-keeping adaptive repetitive learning control
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