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Single cell atlas decodes the molecular dynamics of scar repair after human rotator cuff tear 认领 引用
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作者 Yiming Qin Guang Yang +10 位作者 Tao Zhang Yuying Yang Liyang Wan Tao Zhang Linfeng Wang Zhiyu Hu Zhu Dai Hongkang Zhou Chengjun Li Jianzhong Hu Hongbin Lu 《Bone Research》 SCIE CAS CSCD 2026年第1期259-273,共15页
Irreversible fibrotic scarring after rotator cuff tear(RCT)compromises the mechanical properties of the healing tendon,yet the underlying mechanisms remain poorly understood.Here,we analyzed the histological features ... Irreversible fibrotic scarring after rotator cuff tear(RCT)compromises the mechanical properties of the healing tendon,yet the underlying mechanisms remain poorly understood.Here,we analyzed the histological features of human RCT scars,characterized by disruption of tendon architecture,disorganized collagen fibrils,and imbalance in typeⅠ/Ⅲcollagen ratios and fibril diameters.Using single-cell RNA sequencing of tendon stumps from patients with RCT,we deconvolved the cellular and molecular landscape of the fibrotic scarring microenvironment.Heterogenous pro-fibrotic subclusters were identified and validated to participate into scar formation,including tendon stem cell,senescent tenocyte,SOX9-driven pro-fibrotic macrophage,and pro-fibrotic endothelial cells undergoing endothelial-mesenchymal transition(EndoMT).Furthermore,we found that osteopontin and TGF-βsignaling were key drivers of extracellular matrix deposition,and their blockade ameliorated fibrotic scarring after RCT.Collectively,our study dissected the dynamic scarring microenvironment in human RCT and highlights potential therapeutic targets for preventing pathological scar formation. 展开更多
关键词 cellular molecular landscape disruption tendon architecturedisorganized collagen fibrilsand tendon stumps scar repair rotator cuff tear single cell RNA sequencing rotator cuff tear rct compromises irreversible fibrotic scarring
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The Influence of Discrimination Perception on the Psychological Resilience among Vocational High School Students:Longitudinal Mediating Effect of Vocational Identity 认领 引用
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作者 Lingyan Zhang Yuying Yang Zhuoxuan Huang 《International Journal of Mental Health Promotion》 2026年第2期112-124,共13页
Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental ... Objectives:Psychological resilience is a critical resource for vocational high school students navigating social biases and fostering mental well-being.This six-month longitudinal study investigated the developmental trajectories of discrimination perception,vocational identity,and psychological resilience in this population.It further examined the longitudinal mediating role of vocational identity in the relationship between discrimination perception and psychological resilience.Methods:A total of 526 students from five vocational high schools in Guangdong,China,were assessed via convenience sampling at two time points:baseline(T1,September 2023)and six-month follow-up(T2,March 2024).Measures of discrimination perception,psychological resilience,and vocational identity were administered.Data were analyzed using a cross-lagged panel model to test for bidirectional relationships.Results:Over the six-month period,students showed significant decreases in discrimination perception and vocational identity,but a significant increase in psychological resilience.The cross-lagged model revealed significant bidirectional relationships:discrimination perception and psychological resilience negatively predicted each other over time(β=−0.124,p<0.01;β=−0.200,p<0.001),while psychological resilience and vocational identity positively predicted each other(β=0.084,p<0.05;β=0.076,p<0.05).The mediation analysis revealed a dual-pathway mechanism.T1 discrimination perception exerted both a significant direct negative effect on T2 psychological resilience(β=−0.332,p<0.001)and a significant indirect positive effect via T1 vocational identity(indirect effect=0.020,95%CI[0.001,0.046]).This confirms a partial mediating role,indicating that vocational identity functions as a compensatory mechanism,transforming the experience of discrimination perception into a potential source of psychological resilience.Conclusions:For vocational high school students,perception of discrimination directly undermines psychological resilience,but also indirectly fosters it through the positive development of vocational identity.These findings highlight vocational identity as a pivotal mechanism in the complex relationship between social adversity and mental resilience. 展开更多
关键词 Vocational high school students vocational identity discrimination perception psychological resilience
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Building a“Theoretical and Practical Dual-Qualified”Teacher Team of Sino-Foreign Cooperative Education in Mechanical Engineering:Practical Challenges and Collaborative Development Mechanisms 认领 引用
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作者 Dejian Zhang Liying Gao +1 位作者 Shuhui Xu Yuying Yang 《Journal of Contemporary Educational Research》 2026年第2期7-15,共9页
Against the backdrop of intensifying global industrial upgrading and technological competition,the development of a“theoretical and practical dual-qualified”teaching faculty in mechanical engineering Sino-foreign co... Against the backdrop of intensifying global industrial upgrading and technological competition,the development of a“theoretical and practical dual-qualified”teaching faculty in mechanical engineering Sino-foreign cooperative education programs undertakes the critical mission of cultivating high-level international engineering talent.This holds significant practical importance for both industrial advancement and talent development.Currently,the development of such faculty faces three core bottlenecks:insufficient supply of teacher competencies,outdated practical teaching content,and inadequate industry-education collaboration mechanisms.A systematic reconstruction is proposed across three dimensions:individual teachers,institutional organizations,and industry-institution collaboration,which establishes an individual career pathway based on“technical portfolios,”organizational transformation centered on“teaching innovation teams,”and a practical community characterized by“role integration.”Ultimately,this paper aims to construct a collaborative governance ecosystem involving“government,industry,institutions,and enterprises”in a quadrilateral linkage.This ecosystem,guided by government policies and industry standards,with deep participation from both educational institutions and enterprises,will systematically promote the sustainable cultivation of“Theoretical and practical dual-qualified”teachers and support the high-quality development of mechanical engineering Sino-foreign cooperative education programs. 展开更多
关键词 “Theoretical and practical dual-qualified”teachers Mechanical engineering Sino-foreign cooperative education programs Industry-education integration
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Fiber reinforced ceramic matrix composites:from the controlled fabrication to precision machining 认领 引用 被引量：4
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作者 Shuoshuo Qu Yuying Yang +3 位作者 Peng Yao Luyao Li Yang Sun Dongkai Chu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2025年第6期118-150,共33页
Fiber reinforced ceramic matrix composites(FRCMCs)are the preferred materials for safety critical components in the fields of aerospace,nuclear engineering,and transportation,with broad market and application prospect... Fiber reinforced ceramic matrix composites(FRCMCs)are the preferred materials for safety critical components in the fields of aerospace,nuclear engineering,and transportation,with broad market and application prospects.However,due to the characteristics of multiphase,heterogeneity,and anisotropy,key issues such as poor adhesion,high porosity,and crack propagation urgently need to be addressed in the fabrication and machining of FRCMCs.With the increasing demand for FRCMCs parts,high-quality and reliable design and fabrication,performance evaluation,and precision manufacturing have become a series of hot issues.There is a lack of systematic review in capturing the current research status and development direction of FRCMCs fabrication and machining.This research aims to comprehensively review and critically evaluate the existing understanding of the fabrication and machining of FRCMCs.This study can provide scientists with a deeper understanding of the shape control mechanism of FRCMCs fabrication and machining,the theoretical basis of material synchronous removal,machining performance,and development direction.Firstly,the basic characteristics and application background of FRCMCs are introduced.Secondly,by comparing and analyzing the typical fabrication process of FRCMCs,the advantages,disadvantages,and performance evaluation of different processes are comprehensively evaluated.Thirdly,the material removal mechanisms and machining performance evaluation standards of traditional mechanical machining technologies(drilling,milling,grinding)and non-traditional mechanical machining technologies(ultrasonic,laser,water jet,discharge,wire saw,and multi-field hybrid machining)are discussed and analyzed.Finally,the challenges,development trends,and prospects faced by FRCMCs in the fields of fabrication,machining,and application are analyzed.This study not only elucidates the basic processes and key difficulties in the fabrication of FRCMCs,but also provides valuable insights for low-damage machining. 展开更多
关键词 fiber reinforced ceramic matrix composites removal mechanism traditional mechanical machining technologies non-traditional mechanical machining technologies
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The ameliorative role of phlorotannin on aflatoxin B1‑induced liver oxidative stress and mitochondrial injury is related to the activation of Nrf2 and Nrf1 signaling pathways in broilers 认领 引用 被引量：3
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作者 Xueqing Ye Yuying Yang +4 位作者 Qinghua Yao Mengyi Huang Balamuralikrishnan Balasubramanian Rajesh Jha Wenchao Liu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第5期2195-2212,共18页
Background Aflatoxin B1(AFB1)risks animal and human health,and the liver is considered the most crucial detoxification organ.Phlorotannin(PT)is a polyhydroxy phenol that has a wide range of biological activities... Background Aflatoxin B1(AFB1)risks animal and human health,and the liver is considered the most crucial detoxification organ.Phlorotannin(PT)is a polyhydroxy phenol that has a wide range of biological activities,including antioxidation and hepatoprotection,which can promote the ability of liver detoxification.This study aimed to elucidate the protective effect of PT on AFB1-induced liver damage in broilers.Results In vivo experiment showed that the PT reduced AFB1 content and AFB1-exo-8,9-epoxide DNA(AFBODNA)concentration in serum and liver(P<0.05),improved the histomorphology of liver and hepatic mitochondria,and activated nuclear factor erythroid 2-related factor 2(Nrf2)-related antioxidant and detoxification pathway by upregulating the activities of antioxidant enzymes(catalase[CAT],glutathione S-transferase[GST])and total antioxidant capacity(T-AOC)level(P<0.05),and inhibited the mRNA expression of CYP1A1(cytochrome P450 family 1 subfamily A member 1)and phase Ⅱ detoxification enzyme related genes(GPX1,GSTT1,and NQO1)of broilers exposed to AFB1(P<0.05).Meanwhile,PT upregulated the Nrf1 pathway-related mitochondrial biosynthetic genes(Nrf1,mitochondrial transcription factor A[TFAM],mitofusin 1[MFN1])in broilers fed AFB1 contaminated diet(P<0.05).In vitro verification study suggested that the use of Nrf2/Nrf1 inhibitors suppressed the ameliorative role of PT on AFB1-induced liver injury of broilers,which was manifested in the mRNA expression of Nrf2,NQO1,GSTT3,Nrf1,TFAM,and other genes decreasing(P<0.05),and down-regulation of the protein expression of Nrf2,total and nucleus p-Nrf2,and total and nucleus p-Nrf1(P<0.05).Conclusion The PT ameliorates oxidative stress and hepatotoxicity by activating the Nrf2-mediated phase Ⅱ detoxification enzymes pathway and maintains mitochondrial homeostasis by activating the Nrf1 signaling pathway in broilers exposed to AFB1. 展开更多
关键词 Aflatoxin B1 Biological detoxification Broiler chickens Liver injury Phlorotannin
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Lubricant Transport Mechanism and Dynamics Model for Nepenthes-shaped Biomimetic Microtexture 认领 引用 被引量：2
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作者 Xiaoming Wang Min Yang +7 位作者 Teng Gao Lan Dong Yusuf Suleiman Dambatta Xin Liu Yuying Yang Qinglong An Yanbin Zhang Changhe Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2025年第2期229-246,共18页
During the metal cutting process,especially in continuous contact conditions like turning,the challenge of lubricants failing to effectively reach the cutting point remains unresolved.Micro-textured cutting tools offe... During the metal cutting process,especially in continuous contact conditions like turning,the challenge of lubricants failing to effectively reach the cutting point remains unresolved.Micro-textured cutting tools offer a potential solution for tool-chip contact challenges.Inspired by the evolutionary achievements of the biosphere,micro-textures are expected to overcome lubrication limitations in cutting zones.Drawing on the anti-gravity water transport seen at the mouth edge of the Nepenthes plant,an innovative microchannel with Nepenthes-shaped contours was designed on the rake face to enable controlled lubricant transport.However,the dynamics of lubricant delivery on textured surfaces are not fully understood.This study first analyzed the microstructure and water transport mechanism of Nepenthes to reconstruct a micro-textured surface for controlled lubricant transport.A dynamic model was then developed to describe lubricant transport within open microchannels,with mathematical simulations predicting transport speed and flow distance.To validate this model,diffusion experiments of alumina soybean oil nanolubricant on polycrystalline diamond(PCD)cutting tool surfaces were conducted,showing an average prediction deviation of 5.01%.Compared with the classical Lucas-Washburn model,the new model improved prediction accuracy by 4.72%.Additionally,comparisons were made to examine droplet spreading and non-uniform diffusion on textured surfaces,revealing that the T2 surface exhibited the strongest unidirectional diffusion characteristics.The contact angle ratio,droplet unidirectional spreading ratio,and droplet spreading aspect ratio were 0.48,1.75,and 3.99,respectively.Finally,the anti-wear,friction-reducing,and efficiency-enhancing mechanisms of micro-textured surfaces in minimum quantity lubrication turning were analyzed.This approach may support continuous cutting of difficult-tomachine materials. 展开更多
关键词 Capillary flow Biomimetic microtexture Nepenthes Nanolubricant
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ABF1-MdNRTs/NIAs module mediates ABA-regulated nitrate utilization in apple 认领 引用
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作者 Lin Rui Xue Wang +5 位作者 Guodong Liu Hongliang Li Yuying Yang Ranxin Liu Xiaofei Wang Tingting Zhang 《Fruit Research》 2025年第1期139-153,共15页
Apples are a globally prominent fruit,valued for their texture,flavor,and nutritional value.Apple trees rely heavily on nitrogen,a vital nutrient essential their growth and development.However,the low absorption of ni... Apples are a globally prominent fruit,valued for their texture,flavor,and nutritional value.Apple trees rely heavily on nitrogen,a vital nutrient essential their growth and development.However,the low absorption of nitrogen fertilizers is a significant agricultural challenge,prompting research into improving nitrogen use efficiency.Nitrate is a key form of nitrogen that serves as both a nutrient and a signaling molecule,influencing plant processes.Although hormones such as abscisic acid(ABA)participate in nitrate signaling,the specific mechanisms in apples remain unclear.In this work,we discovered that ABA-regulated MdABF1 negatively regulated nitrate absorption and assimilation by directly downregulating the expression of the MdNIA1 and MdNRT2.3 genes,but activated the expression of MdNRT1.8 to promote nitrate retrieval.These results illustrated the molecular regulatory network through which ABA regulated the utilization of nitrate by the MdABF1-MdNRTs/NIAs module.Taken together,our study offers novel insights into how ABA orchestrates nitrate utilization in apple plants. 展开更多
关键词 ABA mdnrt mdabf apple nitrate utilization mdnia
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AMSA:Adaptive Multi-Channel Image Sentiment Analysis Network with Focal Loss 认领 引用
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作者 Xiaofang Jin Yiran Li Yuying Yang 《Computers, Materials & Continua》 SCIE EI 2025年第12期5309-5326,共18页
Given the importance of sentiment analysis in diverse environments,various methods are used for image sentiment analysis,including contextual sentiment analysis that utilizes character and scene relationships.However,... Given the importance of sentiment analysis in diverse environments,various methods are used for image sentiment analysis,including contextual sentiment analysis that utilizes character and scene relationships.However,most existing works employ character faces in conjunction with context,yet lack the capacity to analyze the emotions of characters in unconstrained environments,such as when their faces are obscured or blurred.Accordingly,this article presents the Adaptive Multi-Channel Sentiment Analysis Network(AMSA),a contextual image sentiment analysis framework,which consists of three channels:body,face,and context.AMSA employs Multi-task Cascaded Convolutional Networks(MTCNN)to detect faces within body frames;if detected,facial features are extracted and fused with body and context information for emotion recognition.If not,the model leverages body and context features alone.Meanwhile,to address class imbalance in the EMOTIC dataset,Focal Loss is introduced to improve classification performance,especially for minority emotion categories.Experimental results have shown that certain sentiment categories with lower representation in the dataset demonstrate leading classification accuracy,the AMSA yields a 2.53%increase compared with state-of-the-art methods. 展开更多
关键词 Image sentiment analysis adaptive multi-channel class imbalance
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Temperature field model in surface grinding: a comparative assessment 认领 引用 被引量：27
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作者 Min Yang Ming Kong +10 位作者 Changhe Li Yunze Long Yanbin Zhang Shubham Sharma Runze Li Teng Gao Mingzheng Liu Xin Cui Xiaoming Wang Xiao Ma Yuying Yang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第4期314-373,共60页
Grinding is a crucial process in machining workpieces because it plays a vital role in achieving the desired precision and surface quality.However,a significant technical challenge in grinding is the potential increas... Grinding is a crucial process in machining workpieces because it plays a vital role in achieving the desired precision and surface quality.However,a significant technical challenge in grinding is the potential increase in temperature due to high specific energy,which can lead to surface thermal damage.Therefore,ensuring control over the surface integrity of workpieces during grinding becomes a critical concern.This necessitates the development of temperature field models that consider various parameters,such as workpiece materials,grinding wheels,grinding parameters,cooling methods,and media,to guide industrial production.This study thoroughly analyzes and summarizes grinding temperature field models.First,the theory of the grinding temperature field is investigated,classifying it into traditional models based on a continuous belt heat source and those based on a discrete heat source,depending on whether the heat source is uniform and continuous.Through this examination,a more accurate grinding temperature model that closely aligns with practical grinding conditions is derived.Subsequently,various grinding thermal models are summarized,including models for the heat source distribution,energy distribution proportional coefficient,and convective heat transfer coefficient.Through comprehensive research,the most widely recognized,utilized,and accurate model for each category is identified.The application of these grinding thermal models is reviewed,shedding light on the governing laws that dictate the influence of the heat source distribution,heat distribution,and convective heat transfer in the grinding arc zone on the grinding temperature field.Finally,considering the current issues in the field of grinding temperature,potential future research directions are proposed.The aim of this study is to provide theoretical guidance and technical support for predicting workpiece temperature and improving surface integrity. 展开更多
关键词 grinding temperature uniform continuous temperature field nonuniform discontinuous temperature field heat source distribution model grinding heat distribution coefficient model convective heat transfer coefficient model
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Advances in fabrication of ceramic corundum abrasives based on sol–gel process 认领 引用 被引量：23
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作者 Baoteng HUANG Changhe LI +12 位作者 Yanbin ZHANG Wenfeng DING Min YANG Yuying YANG Han ZHAI Xuefeng XU Dazhong WANG Sujan DEBNATH Muhammad JAMIL Hao Nan Li Hafiz Muhammad ALI Munish Kumar GUPTA Zafar SAID 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第6期1-17,共17页
Corundum abrasives with good chemical stability can be fabricated into various free abrasives and bonded abrasive tools that are widely used in the precision machining of various parts.However,these abrasives cannot s... Corundum abrasives with good chemical stability can be fabricated into various free abrasives and bonded abrasive tools that are widely used in the precision machining of various parts.However,these abrasives cannot satisfy the machining requirements of difficult-to-machine materials with high hardness,high strength,and strong wearing resistance.Although superhard abrasives can machine the above-mentioned materials,their dressing and manufacturing costs are high.By contrast,ceramic corundum abrasives fabricated by sol–gel method is a costeffective product between conventional and superhard abrasives.Ceramic corundum abrasives exhibit self-sharpening and high toughness.In this review,the optimization methods of ceramic corundum abrasive properties are introduced from three aspects:precursor synthesis,particle shaping,and sintering.Firstly,the functional mechanism of seeds and additives on the microstructural and mechanical properties of abrasives is analyzed.Specifically,seeds can reduce the phase transition temperature and improve fracture toughness.The grain size and uniformly dense structure can be controlled by applying an appropriate amount of multicomponent additives.Then,the urgent need of engineering application and machinability of special shape ceramic corundum abrasives is reviewed,and three methods of abrasive shaping are summarized.The micromold replication technique is highly advanced and can be used to prepare functional abrasives.Additionally,the influence of a new sintering method,namely,two-step sintering technique,on the microstructural and mechanical performance of ceramic corundum abrasives is summarized.Finally,the challenge and developmental trend of the optimization of ceramic corundum abrasives are prospected. 展开更多
关键词 Ceramic corundum abrasive Seed Shaping technique Sintering additive Sol–Gel Two-step sintering process
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Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,China,2016–2020 认领 引用 被引量：22
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作者 Jiayu Wang Jiajing Liu +8 位作者 Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling Liu Chongshan Li Wanju Zhang Xi Zhang Zheng Teng 《Virologica Sinica》 SCIE CAS CSCD 2022年第2期177-186,共10页
Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shang... Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shanghai,China,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December 2020.In the past five years,CVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five years.In addition to entire VP1 sequencing,complete genome sequencing and recombination analysis of CVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic analysis.The CVA10sequences in this study mainly belonged to genogroup C and presented 91%-100%nucleotide identity with other Chinese isolates based on VP1 region.For the first time,our study reported the appearance of CVA10 genogroup D in Chinese mainland,which had led to large-scale outbreaks in Europe previously.The recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with CVA16 genogroup D.To conclusion,CVA10 genogroup C was the predominant genogroup in Shanghai during 2016-2020.CVA10 recombinant genogroup D was firstly reported in circulating in Chinese mainland.Continuous surveillance is needed to better understand the evolution relationships and transmission pathways of CVA10 to help to guide disease control and prevention. 展开更多
关键词 Coxsackievirus A10(CVA10) Genogroup D Intertypic recombination Hand foot and mouth disease(HFMD)
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Optimum Location of Tube Blank in Electromagnetic Bulging 认领 引用 被引量：1
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作者 Zhiheng ZHAO Chunfeng LI +1 位作者 YongZhi WANG Yuying YANG 《Journal of Materials Science & Technology》 SCIE EI CAS 2001年第1期117-118,共2页
Using analytical method, this paper gets 'the mutual inductance between coil and workpiece in tube blank electromagnetic bulging. According to this, we obtain the optimum locations of tube blank with different len... Using analytical method, this paper gets 'the mutual inductance between coil and workpiece in tube blank electromagnetic bulging. According to this, we obtain the optimum locations of tube blank with different length of coil and workpiece. There is a good agreement between results calculated and the experimental data. 展开更多
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Research on Sarcasm Detection Technology Based on Image-Text Fusion 认领 引用
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作者 Xiaofang Jin Yuying Yang +1 位作者 YinanWu Ying Xu 《Computers, Materials & Continua》 SCIE EI 2024年第6期5225-5242,共18页
The emergence of new media in various fields has continuously strengthened the social aspect of social media.Netizens tend to express emotions in social interactions,and many people even use satire,metaphors,and other... The emergence of new media in various fields has continuously strengthened the social aspect of social media.Netizens tend to express emotions in social interactions,and many people even use satire,metaphors,and other techniques to express some negative emotions,it is necessary to detect sarcasm in social comment data.For sarcasm,the more reference data modalities used,the better the experimental effect.This paper conducts research on sarcasm detection technology based on image-text fusion data.To effectively utilize the features of each modality,a feature reconstruction output algorithm is proposed.This algorithm is based on the attention mechanism,learns the low-rank features of another modality through cross-modality,the eigenvectors are reconstructed for the corresponding modality through weighted averaging.When only the image modality in the dataset is used,the preprocessed data has outstanding performance in reconstructing the output model,with an accuracy rate of 87.6%.When using only the text modality data in the dataset,the reconstructed output model is optimal,with an accuracy rate of 85.2%.To improve feature fusion between modalities for effective classification,a weight adaptive learning algorithm is used.This algorithm uses a neural network combined with an attention mechanism to calculate the attention weight of each modality to achieve weight adaptive learning purposes,with an accuracy rate of 87.9%.Extensive experiments on a benchmark dataset demonstrate the superiority of our proposed model. 展开更多
关键词 Sentiment analysis sarcasm detection feature fusion feature reconstruction
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Functional identification of the bHLH transcription factor MdSAT1 in the phosphate deficiency response 认领 引用
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作者 Tong Li Ziquan Feng +5 位作者 Yuying Yang Mingli Li Guodong Li Chunxiang You Wensheng Gao Xiaofei Wang 《Fruit Research》 2023年第1期96-104,共9页
Inorganic phosphate(Pi)starvation severely affects the normal growth and development of plants.In this study,MdSAT1,a Pi-responsive bHLH transcription factor,was isolated from apples.Ectopic expression of MdAST1 in Ar... Inorganic phosphate(Pi)starvation severely affects the normal growth and development of plants.In this study,MdSAT1,a Pi-responsive bHLH transcription factor,was isolated from apples.Ectopic expression of MdAST1 in Arabidopsis increased the number of lateral roots and root tips,as well as the transcript levels of genes related to Pi uptake and transport;thus,improving Pi utilization in response to a Pi deficiency.Ectopic expression of MdSAT1 significantly accelerated flowering and leaf senescence in Arabidopsis under a Pi deficiency.Taken together,the present study provides a basis for an in-depth investigation of the mechanisms of MdSAT1 on apple Pi uptake and utilization as well as plant growth and development. 展开更多
关键词 phosphate deficiency transcription factor root development pi uptake pi transport mdsat flowering pi starvation
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非洲猪瘟病毒的免疫逃逸策略 认领 引用 被引量：20
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作者 孙茂文 王涛 +2 位作者 孙元 杨玉莹 仇华吉 《微生物学报》 CAS CSCD 北大核心 2021年第2期249-262,共14页
非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种猪烈性传染病。目前无商品化的ASF疫苗,一旦发病,仅能依靠快速扑杀进行防控,严重威胁我国养猪及相关行业的健康发展。ASF疫苗研发面临的... 非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种猪烈性传染病。目前无商品化的ASF疫苗,一旦发病,仅能依靠快速扑杀进行防控,严重威胁我国养猪及相关行业的健康发展。ASF疫苗研发面临的主要困难是对ASFV的毒力相关基因、致病及其免疫逃逸机制知之甚少。本文对ASFV的免疫逃逸研究进行了总结,探讨了ASFV免疫逃逸基因及其编码蛋白的功能,以便加深对ASFV及其免疫逃逸策略的认知,为致病机制研究和疫苗研发提供借鉴。 展开更多
关键词 非洲猪瘟病毒 免疫逃逸 天然免疫 适应性免疫
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长链非编码RNA--抗病毒天然免疫应答的新兴调控因子 认领 引用 被引量：6
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作者 张华伟 孟星宇 +2 位作者 李连峰 杨玉莹 仇华吉 《遗传》 CAS CSCD 北大核心 2018年第7期525-533,共9页
长链非编码RNA(long non-coding RNAs,lncRNAs)是长度超过200nt的非编码RNA分子的总称。作为一类重要的基因调控因子,lncRNAs在表观遗传学、转录及转录后等多个水平调控靶基因的表达。近年来的研究表明,许多lncRNAs可被病毒或干扰素(int... 长链非编码RNA(long non-coding RNAs,lncRNAs)是长度超过200nt的非编码RNA分子的总称。作为一类重要的基因调控因子,lncRNAs在表观遗传学、转录及转录后等多个水平调控靶基因的表达。近年来的研究表明,许多lncRNAs可被病毒或干扰素(interferon,IFN)诱导表达,并作为调控因子在IFN介导的抗病毒天然免疫应答中调节抗病毒相关基因的表达。本文重点阐述了lncRNAs在IFN介导的抗病毒天然免疫应答中的调控作用,尤其是对干扰素刺激基因(interferon-stimulated genes,ISGs)转录的调控作用,并归纳了lncRNAs、IFN和ISGs形成的调控网络,以期为从事lncRNAs调控IFN介导的抗病毒天然免疫应答机制研究的相关科研人员提供参考。 展开更多
关键词 长链非编码RNA 干扰素 干扰素刺激基因 抗病毒天然免疫应答
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2018年上海市一起D8基因型麻疹病毒引起的输入性麻疹暴发报告 认领 引用 被引量：11
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作者 李崇山 李智 +9 位作者 王静 胡家瑜 唐伟 杨玉颖 李云逸 杨彦基 崔晓娴 叶玉龙 张曦 袁政安 《疾病监测》 CAS 2019年第7期672-675,共4页
目的追踪2018年上海市一起输入性麻疹暴发的来源,并分析其病毒分子流行病学特征。方法直接从临床咽拭子标本中提取病毒核酸,采用一步法反转录–聚合酶链式反应,扩增麻疹病毒核蛋白基因COOH末端676个核苷酸,然后对扩增产物进行核苷酸序... 目的追踪2018年上海市一起输入性麻疹暴发的来源,并分析其病毒分子流行病学特征。方法直接从临床咽拭子标本中提取病毒核酸,采用一步法反转录–聚合酶链式反应,扩增麻疹病毒核蛋白基因COOH末端676个核苷酸,然后对扩增产物进行核苷酸序列测定,并分析其同源性,以确定病毒基因型及其可能的来源。结果本次暴发病例来自于同一家庭,且2例成年人病例在发病前21 d内有共同的出境旅游史;导致此次暴发的麻疹病毒为D8基因型。结论结合流行病学调查和实验室检测结果,推断此次疫情为一起D8基因型麻疹病毒引起的输入性麻疹暴发。 展开更多
关键词 麻疹病毒 输入性暴发 基因型
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Recent Advances in Genetic Engineering of Microalgae 认领 引用
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作者 Jinfei YAN Yuying YANG Shuxia MA 《Agricultural Biotechnology》 2016年第6期37-43,共7页
Metsbolites generated by microalgac cell metabolism have practical application value in the fields of medicine, food, feed and energy. At present, with the development of genetic engineering techniques and continuous ... Metsbolites generated by microalgac cell metabolism have practical application value in the fields of medicine, food, feed and energy. At present, with the development of genetic engineering techniques and continuous reduction in gene sequencing costs, some micrcalgal genomes have been successively published, which enables specific genetic modification of microalgae according to human＇s demand and provides broad application prospects. In this paper, different mediating systems and emerging genome editing techniques were summarized, which laid the foundation for the application of genetic engineering methods for microalgae. 展开更多
关键词 Microalgae Genetic modification Genome editing techniques
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肠杆菌共同抗原的研究进展 认领 引用 被引量：2
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作者 沈雪刚 杨玉莹 +2 位作者 李沛 罗洪艳 孔庆科 《生物工程学报》 CAS CSCD 北大核心 2021年第4期1081-1091,共11页
肠杆菌共同抗原(Enterobacterial common antigen,ECA)是由多糖重复单元组成的多聚糖,几乎表达于所有肠杆菌细菌外膜,具有生物学功能。ECA由多基因协同作用而合成,这些基因在肠杆菌细菌基因组上成簇存在,形成ECA抗原基因簇。ECA是重要... 肠杆菌共同抗原(Enterobacterial common antigen,ECA)是由多糖重复单元组成的多聚糖,几乎表达于所有肠杆菌细菌外膜,具有生物学功能。ECA由多基因协同作用而合成,这些基因在肠杆菌细菌基因组上成簇存在,形成ECA抗原基因簇。ECA是重要的毒力因子,在肠杆菌细菌入侵宿主、体内存活等过程中有一定作用。同时,ECA在维持细菌外膜渗透屏障、鞭毛表达、群集运动及抗胆酸胆盐等方面也有重要作用。此外,锚定在细菌脂多糖核心区的ECALPS还是细菌重要的表面抗原,能激发宿主产生高水平抗体,可以作为疫苗研究的靶点。结合笔者的研究,文中对ECA纯化、基因结构和合成、免疫特性、生物学功能及应用等方面进行了综述。 展开更多
关键词 肠杆菌 肠杆菌共同抗原 生物合成 免疫特性 毒力
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细菌小细胞在癌症治疗中的应用 认领 引用 被引量：1
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作者 杨玉莹 刘青 +3 位作者 李沛 罗洪艳 王豪举 孔庆科 《生物工程学报》 CAS CSCD 北大核心 2019年第6期998-1008,共11页
癌症一直是危害人类健康的主要疾病之一。传统的癌症治疗方法包括放疗、化疗和手术,均具有明显的毒副作用或局限性。脂质体和纳米颗粒作为被广泛研究的药物递送载体,在人体临床试验中也出现了药物渗漏和装载功能不全等问题。目前而言,... 癌症一直是危害人类健康的主要疾病之一。传统的癌症治疗方法包括放疗、化疗和手术,均具有明显的毒副作用或局限性。脂质体和纳米颗粒作为被广泛研究的药物递送载体,在人体临床试验中也出现了药物渗漏和装载功能不全等问题。目前而言,应用具有肿瘤靶向性的载体递送抗肿瘤药物或小分子,是有希望介导安全、有效的肿瘤治疗的策略之一。近年来,细菌来源的非复制型小细胞已受到越来越多的关注。小细胞是细菌异常分裂时期产生的纳米级无核细胞,其直径为200–400 nm,因而具有较大的药物装载能力。对小细胞的表面进行修饰,例如,装配能与肿瘤细胞表面特异性抗原或受体结合的抗体/配体,可显著提高小细胞的肿瘤靶向性。这种具有靶向性的纳米材料能将抗肿瘤的化疗药物、功能性核酸或编码功能性小分子的质粒靶向递送至肿瘤,而减少药物在正常组织器官的集聚。因此,使用小细胞作为靶向递送载体有助于降低药物对机体的毒性,从而最大限度地发挥药物分子在体内的抗肿瘤活性。文中将对小细胞的产生与纯化、药物装载、肿瘤细胞靶向性、内化过程以及其用于递送抗肿瘤药物的研究进展等方面进行综述,为开发基于小细胞的癌症治疗策略提供一定的参考。 展开更多
关键词 小细胞 癌症治疗 纳米颗粒
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