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The impact of Cistanche on the therapeutic potential of acne after fermentation with Beauveria bassiana 认领 引用
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作者 Xingjiang Zhang Pan Wang +9 位作者 Yunwei Hu Hui Ke Rui Wang Xiaoya Zhang Huiyun Wu Baiyi Chi Yuyo Go Xi Hui Felicia Chan Qing Huang Jianxin Wu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1168-1178,共11页
Phenylethanol glycosides(PhGs) constitute crucial bioactive compounds in Cistanche Herba.However,their bioavailability is notably low.Research indicates that intestinal flora can metabolize PhGs into small polyphenols... Phenylethanol glycosides(PhGs) constitute crucial bioactive compounds in Cistanche Herba.However,their bioavailability is notably low.Research indicates that intestinal flora can metabolize PhGs into small polyphenols,enhancing bioavailability and pharmacological activities.In this paper,for the first time,a single strain,Beauveria bassiana,was found to be effective in converting PhGs from the crude extract of Cistanche tubulosa into small molecule polyphenols like hydroxytyrosol(HT),decaffeoylacteoside(HT-glu-rha),and caffeic acid through fermentation.We assessed the impact of pre-and post-fermentation on Propionibacterium acnes-induced acne related to a Western diet through in vitro cellular experiments.Both pre-and post-fermentation exhibited efficacy in inhibiting inflammation,oxidative stress,and mitochondrial membrane damage in P.acnes-induced HaCaT.Moreover,post-fermentation,unlike pre-fermentation,displayed stronger and a dose-dependent reduction in insulin-stimulated lipid synthesis in sebaceous gland cells.To further understand the increased efficacy of fermentation in inhibiting lipid synthesis,we investigated HT-glu-rha,the predominant small molecules produced during fermentation.It was shown that the compound inhibited lipid synthesis by decreasing gene expression of sterol regulatory element binding transcription factor 1(SREBP-1) and peroxisome proliferator activated receptor gamma(PPARγ) in sebaceous gland cells. 展开更多
关键词 Cistanche Fermentation Beauveria bassiana Acne Decaffeoylacteoside
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Porous Organic Cages with Aggregation-Induced Emission Property for Anti-counterfeiting Ink Bioimaging 认领 引用
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作者 Anli Yang Yifan Guo +6 位作者 Yanji Zhang Zhuolin Yang Yuyo Go Di Wu Chunzheng Ma Linlin Shi Bingjie Li 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2025年第4期270-277,共8页
The application of aggregation-induced emission(AIE)materials in biological imaging holds multiple significances,including improving detection sensitivity and specificity,optimizing the imaging process,expanding the s... The application of aggregation-induced emission(AIE)materials in biological imaging holds multiple significances,including improving detection sensitivity and specificity,optimizing the imaging process,expanding the scope of application,and promoting advancements in biomedical research.In this work,the propeller ligand was constructed through McMurry coupling reaction and Suzuki coupling reaction by using dimethoxybenzophenone as the starting material.Then,an imine condensation reaction was carried out in chloroform solution,using a 3:2 molar ratio of precursor to tri(2-aminoethyl)amine to synthesize C3 symmetric porous organic cage CB.The structures of the compounds were determined by nuclear magnetic resonance spectroscopy(NMR),electrospray ionization mass spectrometry(ESI-MS)and Fourier transform infrared spectroscopy(FT-IR).The optical investigation results reveal that ligand L-B and the porous organic cage CB demonstrate remarkable aggregation-induced emission(AIE)properties in a tetrahydrofuran/water mixed solvent system,along with a pronounced response to tetrahydrofuran vapor stimuli.Consequently,Furthermore,given its unique cage-like structure,high quantum yield,and outstanding AIE behavior,the porous organic cage CB holds promise for applications in cell imaging. 展开更多
关键词 AIE anti-counterfeiting bioimaging caged-structures
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Recent advances in photocatalytic C-H amination to nitrogenous structures 认领 引用
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作者 Chunzheng Ma Yuanyuan Chang +6 位作者 Jessie Yang Lu Chen Di Wu Yuyo Go Bin Wang Linlin Shi Bingjie Li 《Green Synthesis and Catalysis》 CSCD 2026年第1期16-33,共18页
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity,surpassing non-nitrogen architectures.Given the vast array of nitrogen-containing compounds and their crucial rol... Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity,surpassing non-nitrogen architectures.Given the vast array of nitrogen-containing compounds and their crucial role in the pharmaceutical industry,chemists have been motivated to devise efficient,cost-effective,and practical methods for C-N bond formation.Significant advancements have been achieved in this cutting-edge field over the past few decades.This review aims to encapsulate the latest progress in C-N bond formation via the photocatalytic C-H amination process.Initially,we provide a comprehensive introduction to C-H amination transformations.Subsequently,we categorize these photochemical conversions into two parts:intramolecular and intermolecular C-H amination.To elucidate the underlying principles of specific illustrative examples,we have carefully chosen and elaborated on the reaction mechanisms,representative experimental outcomes,and applications. 展开更多
关键词 Photocatalytic transformation C-N formation C-H amination Nitrogenous structures
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