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Insights into the dissolution kinetics of copper-nickel tailings for CO2mineral sequestration 认领 引用
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作者 Zhenghong Yang Haiyun Gu +3 位作者 Sijia Liu Kai Wu Linglin Xu Lijie Guo 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2025年第9期2119-2130,共12页
Copper-nickel tailings(CNTs),consisting of more than 80wt%magnesium-bearing silicate minerals,show great potential for CO2mineral sequestration.The dissolution kinetics of CNTs in HCl solution was investigated thro... Copper-nickel tailings(CNTs),consisting of more than 80wt%magnesium-bearing silicate minerals,show great potential for CO2mineral sequestration.The dissolution kinetics of CNTs in HCl solution was investigated through a leaching experiment and kinetic modeling,and the effects of reaction time,HCl concentration,solid-to-liquid ratio,and reaction temperature on the leaching rate of mag-nesium were comprehensively studied.Results show that the suitable leaching conditions for magnesium in CNTs are 2 M HCl,a solid-to-liquid ratio of 50 g·L−1,and 90℃,at which the maximum leaching rate of magnesium is as high as 83.88%.A modified shrinking core model can well describe the leaching kinetics of magnesium.The dissolution of magnesium was dominated by a combination of chemical reaction and product layer diffusion,with a calculated apparent activation energy of 77.51 kJ·mol−1.This study demonstrates the feasibil-ity of using CNTs as a media for CO2mineral sequestration. 展开更多
关键词 copper-nickel tailings dissolution kinetics magnesium leaching shrinking core model CO2mineral sequestration
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Syntax-Enhanced Entity Relation Extraction with Complex Knowledge 认领 引用
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作者 Mingwen Bi Hefei Chen Zhenghong Yang 《Computers, Materials & Continua》 SCIE EI 2025年第4期861-876,共16页
Entity relation extraction,a fundamental and essential task in natural language processing(NLP),has garnered significant attention over an extended period.,aiming to extract the core of semantic knowledge from unstruc... Entity relation extraction,a fundamental and essential task in natural language processing(NLP),has garnered significant attention over an extended period.,aiming to extract the core of semantic knowledge from unstructured text,i.e.,entities and the relations between them.At present,the main dilemma of Chinese entity relation extraction research lies in nested entities,relation overlap,and lack of entity relation interaction.This dilemma is particularly prominent in complex knowledge extraction tasks with high-density knowledge,imprecise syntactic structure,and lack of semantic roles.To address these challenges,this paper presents an innovative“character-level”Chinese part-of-speech(CN-POS)tagging approach and incorporates part-of-speech(POS)information into the pre-trained model,aiming to improve its semantic understanding and syntactic information processing capabilities.Additionally,A relation reference filling mechanism(RF)is proposed to enhance the semantic interaction between relations and entities,utilize relations to guide entity modeling,improve the boundary prediction ability of entity models for nested entity phenomena,and increase the cascading accuracy of entity-relation triples.Meanwhile,the“Queue”sub-task connection strategy is adopted to alleviate triplet cascading errors caused by overlapping relations,and a Syntax-enhanced entity relation extraction model(SE-RE)is constructed.The model showed excellent performance on the self-constructed E-commerce Product Information dataset(EPI)in this article.The results demonstrate that integrating POS enhancement into the pre-trained encoding model significantly boosts the performance of entity relation extraction models compared to baseline methods.Specifically,the F1-score fluctuation in subtasks caused by error accumulation was reduced by 3.21%,while the F1-score for entity-relation triplet extraction improved by 1.91%. 展开更多
关键词 Entity relation extraction complex knowledge syntax-enhanced semantic interaction pre-trained BERT
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多原发肺癌诊疗策略的最新进展 认领 引用 被引量：6
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作者 李邦胜 杨政鸿 +2 位作者 赵应鼎 陈颖 黄云超 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第11期863-873,共11页
随着后疫情时代的到来,计算机断层扫描在肺癌筛查中运用愈加广泛,多原发性肺癌(multiple primary lung cancer, MPLC)的检出率在不同国家和地区也随之飙升。尽管先进的组织学和测序技术不断应用于该领域,但MPLC和肺内转移(intrapulmonar... 随着后疫情时代的到来,计算机断层扫描在肺癌筛查中运用愈加广泛,多原发性肺癌(multiple primary lung cancer, MPLC)的检出率在不同国家和地区也随之飙升。尽管先进的组织学和测序技术不断应用于该领域,但MPLC和肺内转移(intrapulmonary metastasis, IM)的鉴别仍具有挑战性。近年来,遗传和环境因素在MPLC中的特殊机制逐渐被人们发掘。在MPLC的治疗中,肺叶切除术仍然居于主要地位,但特定肿瘤亚肺叶切除并未对生存产生负面影响,这似乎是一种合理的选择。随着理念的革新,以手术为主的综合治疗是一种新趋势。其中,立体定向消融放疗(stereotactic ablative radiotherapy, SABR)和肺消融技术成为早期不可切除肿瘤和控制残留病灶的有效治疗手段。此外,驱动基因阳性的靶向治疗和免疫治疗在术后辅助阶段也显示出良好的结果。本文拟基于最新的研究成果对MPLC的管理进行综述。 展开更多
关键词 肺肿瘤 第二代测序技术 手术 放射治疗 消融 靶向治疗 免疫治疗
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DDAH1 promotes neurogenesis and neural repair in cerebral ischemia 认领 引用 被引量：4
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作者 Qiming Gao Pinfei Ni +23 位作者 Yilin Wang Peiyun Huo Xiaojie Zhang Sihan Wang Fuyao Xiao Yixuan Li Wei Feng Juntao Yuan Teng Zhang Qiang Li Boyu Fan Yuhao Kan Zhirui Li Yimiao Qi Junfei Xing Zhenghong Yang Haixiao Cheng Xinran Gao Xiaoyan Feng Ming Xue Yang Liu Yumin Luo Zhongbing Lu Yuming Zhao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第5期2097-2118,共22页
Choline acetyltransferase(ChAT)-positive neurons in neural stem cell(NSC)niches can evoke adult neurogenesis(AN)and restore impaired brain function after injury,such as acute ischemic stroke(AIS).However,the relevant ... Choline acetyltransferase(ChAT)-positive neurons in neural stem cell(NSC)niches can evoke adult neurogenesis(AN)and restore impaired brain function after injury,such as acute ischemic stroke(AIS).However,the relevant mechanism by which ChAT+neurons develop in NSC niches is poorly understood.Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1(DDAH1),a hydrolase for asymmetric NG,NG-dimethylarginine(ADMA),regulated genes responsible for the synthesis and transportation of acetylcholine(ACh)(Chat,Slc5a7 and Slc18a3)after stroke insult.The dual-luciferase reporter assay further suggested that DDAH1 controlled the activity of ChAT,possibly through hypoxia-inducible factor 1α(HIF-1α).KC7F2,an inhibitor of HIF-1α,abolished DDAH1-induced ChAT expression and suppressed neurogenesis.As expected,DDAH1 was clinically elevated in the blood of AIS patients and was positively correlated with AIS severity.By comparing the results among Ddah1 general knockout(KO)mice,transgenic(TG)mice and wild-type(WT)mice,we discovered that DDAH1 upregulated the proliferation and neural differentiation of NSCs in the subgranular zone(SGZ)under ischemic insult.As a result,DDAH1 may promote cognitive and motor function recovery against stroke impairment,while these neuroprotective effects are dramatically suppressed by NSC conditional knockout of Ddah1 in mice. 展开更多
关键词 DDAH1 Neurogenesis Neural repair ChAT HIF-1α ACh Stroke ADMA
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