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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke 认领 引用 被引量：9
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作者 Jian Yang Jiang Wu +7 位作者 Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第7期2015-2028,共14页
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe n... Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.Ferroptosis is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic stroke.However,there are few studies on oligodendrocyte progenitor cell ferroptosis.We analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral ischemia.Bioinformatics analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ferroptosis.PLIN2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet accumulation.For further investigation,we established a mouse model of cerebral ischemiaeperfusion.We found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct area.The ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin injury.We also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor cells.Plin2 knockdown rescued demyelination and improved neurological deficits.Our findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia. 展开更多
关键词 bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing
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Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol 认领 引用 被引量：6
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作者 Xifan Wang Yanling Hao +5 位作者 Xiaoxue Liu Shoujuan Yu Weibo Zhang Songtao Yang Zhengquan Yu Fazheng Ren 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2019年第8期409-412,共4页
End stage renal disease (ESRD), an advanced stage of chronic kidney disease, has received increasing attention as a leading public health problem (Webster et al., 2017). Chronic kidney disease (CKD) and ESRD are invar... End stage renal disease (ESRD), an advanced stage of chronic kidney disease, has received increasing attention as a leading public health problem (Webster et al., 2017). Chronic kidney disease (CKD) and ESRD are invariably accompanied by chronic systemic inflammation which plays central roles in CKD progression (Cachofeiro et al., 2008) and the increased mortality due to cardiovascular disease (Landray et al., 2004). 展开更多
关键词 Gut microbiota end-stage renal
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Cuproptosis-related gene-based characterization and diagnostic biomarker screening in gliomas 认领 引用
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作者 Xi Shen Jiandong Zhu +4 位作者 Yuhang Gu Weiwei Zhai Liang Sun Jiang Wu Zhengquan Yu 《Journal of Cancer Metastasis and Treatment》 2025年第1期331-350,共20页
Aim:Glioma,the most common primary brain tumor,is known for its poor prognosis,limited treatment success,and high level of aggressiveness.Although cuproptosis-related genes have been linked to outcomes in other cancer... Aim:Glioma,the most common primary brain tumor,is known for its poor prognosis,limited treatment success,and high level of aggressiveness.Although cuproptosis-related genes have been linked to outcomes in other cancers,their role in glioma is still not well understood.Methods:By leveraging the Cancer Genome Atlas(TCGA)and additional databases,we conducted Cox regression and Kaplan-Meier analysis to determine the predictive importance of cuproptosis-related genes in individuals with glioma.By utilizing data from Gene Expression Omnibus(GEO)and other relevant databases,we examined how the expression of cuproptosis-associated genes correlates with immune cell infiltration,immunological checkpoint status,pathological stage,and histological grade.Additionally,we analyzed the connection between gene expression linked to cuproptosis and the prognosis in glioma patients.Results:Our newly developed cuproptosis-based glioma predictive model demonstrated promising prediction performance.Additionally,we identified glutaminase(GLS)in glioblastoma as a potential novel diagnostic indicator for glioma patients.Conclusion:GLS holds the potential to provide novel perspectives on cancer management and serve as a valuable diagnostic predictor for glioma patients. 展开更多
关键词 Cuproptosis-related gene diagnostic glioma GLS biomarker
TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation 认领 引用 被引量：1
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作者 Guotao Yu Fang Wang +19 位作者 Menghao You Tiansong Xu Chunlei Shao Yuning Liu Ruiqi Liu Min Deng Zhihong Qi Zhao Wang Jingjing Liu Yingpeng Yao Jingjing Chen Zhen Sun Shanshan Hao Wenhui Guo Tianyan Zhao Zhengquan Yu Qian Zhang Yaofeng Zhao Feng Chen Shuyang Yu 《Protein & Cell》 SCIE CSCD 2020年第5期380-386,共7页
Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of ... Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease,allergy,diabetes,obesity,and inflammatory bowel disease(IBD),which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models(Saleh and Elson,2011). 展开更多
关键词 inflammation homeostasis diseases
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Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330 认领 引用
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作者 Mengxu GE Fei LIU +8 位作者 Fei CHANG Zhaolin SUN Jing FEI Ying GUO Yunping DAI Zhengquan YU Yaofeng ZHAO Ning LI Qingyong MENG 《Frontiers of Agricultural Science and Engineering》 2015年第3期242-248,共7页
Lactoferrin is a member of the transferrin family of multifunctional iron binding glycoproteins.While numerous physiological functions have been described for lactoferrin,the mechanisms underlying these functions are ... Lactoferrin is a member of the transferrin family of multifunctional iron binding glycoproteins.While numerous physiological functions have been described for lactoferrin,the mechanisms underlying these functions are not clear.To further study the functions and mechanisms of lactoferrin,we modified the lactoferrin promoter of mice using the CRISPR/Cas9 system to reduce or eliminate lactoferrin expression.Seven mice with lactoferrin promoter mutations were obtained with an efficiency of 24%(7/29)by injecting the plasmid pX330,expressing a small guide RNA and human codonoptimized SpCas9,into fertilized eggs of mice.Plasmid integration and off-targeting of pX330 were not detected.These results confirmed that pronuclear injection of a circular plasmid is a feasible and efficient method for targeted mutagenesis in mice. 展开更多
关键词 lactoferrin promoter CRISPR/Cas9 plasmid pX330
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