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A critical review on chemical constituents and pharmacological effects of Lilium 认领 引用 被引量：16
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作者 Pengyu Wang Jian Li +4 位作者 Fatma Alzahra K.Attia Wenyi Kang Jinfeng Wei Zhenhua Liu Changqin Li 《Food Science and Human Wellness》 SCIE CAS 2019年第4期330-336,共7页
Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,... Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium. 展开更多
关键词 Lilium Chemical constituents Pharmacological effects
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Advances in the treatment of metastatic prostate cancer in China 认领 引用 被引量：2
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作者 Baojun Wang Zhenhua Liu +1 位作者 Luyao Yang Xu Zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第5期433-438,共6页
Prostate cancer (PC) is among the most common cancer diagnoses in men worldwide and the fifth leading cause of cancer-related deaths. Approximately 1.5 million new cases of PC were reported worldwide in 2022 with near... Prostate cancer (PC) is among the most common cancer diagnoses in men worldwide and the fifth leading cause of cancer-related deaths. Approximately 1.5 million new cases of PC were reported worldwide in 2022 with nearly 400,000 associated deaths1. Notably, the incidence of PC in China has increased substantially compared to the global average2. 展开更多
关键词 prostate cancer incidence mortality China metastatic prostate cancer treatment
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Advancing grape breeding through an in vitro embryo germination technique without cold stratification 认领 引用 被引量：2
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作者 Zhenhua Liu Jing Song +7 位作者 Yan Wang Ailing Yan Xiaoyue Wang Huiling Wang Jiancheng Ren Haiying Xu Pingyin Guan Lei Sun 《Horticultural Plant Journal》 SCIE CAS CSCD 2025年第4期1483-1492,共10页
In grape breeding programs,the extensive planting of seedlings is a crucial aspect.However,grape seeds display distinct dormancy traits,necessitating a prolonged cold stratification process for dormancy release.In ord... In grape breeding programs,the extensive planting of seedlings is a crucial aspect.However,grape seeds display distinct dormancy traits,necessitating a prolonged cold stratification process for dormancy release.In order to enhance the efficiency of breeding programs,this study presents an innovative in vitro embryo germination technique that eliminates the requirement for cold stratification of seeds.The method involves the disruption of peripheral tissue in grape seed embryos using a straightforward mechanical technique,resulting in the efficient production of a substantial quantity of seed embryos,with a germination rate of up to 88% for these isolated embryos.These embryos are subsequently cultured in vitro to facilitate germination into seedlings,thereby eliminating the need for cold stratification.Consequently,grape seedlings can be obtained within a significantly reduced timeframe of 30-38 d,expediting the overall grape breeding process.This novel approach not only accelerates grape hybridization but also streamlines the selection of new grape varieties,contributing to an efficient and time-sensitive breeding methodology. 展开更多
关键词 Grape Seed dormancy Germination Embryo culture
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Isobavachromene ameliorates insulin resistance via inactivating the MAPK/NF-κB signaling pathway 认领 引用
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作者 Zhenhua Liu Zhenhua Liang +5 位作者 Lanting Xu Jiajia Yuan Yiqi Li Wenyi Kang Yan Zhang Bin Cong 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第8期3010-3018,共9页
Inflammation caused by obesity,particularly in adipose tissue and the liver,can lead to insulin resistance(IR)and trigger type 2 diabetes mellitus(T2DM).It is crucial to identify therapeutic agents that alleviate IR b... Inflammation caused by obesity,particularly in adipose tissue and the liver,can lead to insulin resistance(IR)and trigger type 2 diabetes mellitus(T2DM).It is crucial to identify therapeutic agents that alleviate IR by reducing inflammation.Here,we report that isobavachromene(IB),a flavonoid derived from Psoralea corylifolia Linn.,ameliorates IR in 3T3-L1 adipocytes by inhibiting the mitogen-activated protein kinase(MAPK)and nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)signaling pathway.We first found that IB could promote glucose uptake in 3T3-L1 adipocytes by activating the phosphoinositide 3-kinase(PI-3K)/protein kinase B(Akt)signaling pathway and was more effective than the positive control sodium orthovanadate at concentrations ranging from 25 to 100μmol/L.Additionally,IB inhibited RAW264.7 macrophage infiltration into 3T3-L1 adipocytes and suppressed the secretion of inflammatory factors from RAW264.7 macrophages,as well as the phosphorylation levels of key proteins(NF-κB p65,extracellular-signal-regulated kinase 1/2(ERK1/2),Jun N-terminal kinase(JNK),and mitogen-activated protein kinase 38(p38))in the NF-κB and MAPK signaling pathways.In summary,IB improves glucose uptake in IR adipocytes,activates the PI-3K/Akt signaling pathway,inhibits the JNK and NF-κB inflammatory signaling pathways,and reduces adipocyte inflammation,thereby improving of IR in 3T3-L1 adipocytes. 展开更多
关键词 Isobavachromene Diabetes Insulin resistance Inflammation MAPK/NF-κB
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Different kinds of functional components with multiple biological activities in Cornus officinalis as food and medicinal resource: a review 认领 引用
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作者 Yuhang Liu Lili Cui +3 位作者 Wenyi Kang Zhenhua Liu Yan Zhang Changyang Ma 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第12期4717-4754,共38页
Cornus officinalis Sieb.et Zucc.,a valuable Chinese medicine resource,has a long clinic utilization history.In recent years,more research focus on the chemical composition and pharmacological activity of C.officinalis... Cornus officinalis Sieb.et Zucc.,a valuable Chinese medicine resource,has a long clinic utilization history.In recent years,more research focus on the chemical composition and pharmacological activity of C.officinalis which was used as health foods and drugs.This paper summarized the active ingredients,pharmacological activities and molecular mechanisms of C.officinalis in recent 5 years to provide reference for the development and utilization of C.officinalis.A total of 149 active constituents of C.officinalis were summarized,including iridoids(64),flavonoids(18),lignin(17),tannins(16),organic acids and phenolic acids(14),triterpenes(11)and others(9),which were further subdivided according to their pharmacological effects.It was found that the pharmacological effects of C.officinalis were very extensive,mainly including antioxidant,anti-inflammatory,anti-tumor,neuroprotective and other biological activities.Among these activities,the anti-inflammatory and hypoglycemic mechanisms showed multi-pathway and multi-target characteristics,which were elaborated systematically.However,there are still many compounds in C.officinalis that have not been studied for biological activity,which means that it still has potential pharmacological activity to be further studied.C.officinalis not only has high medicinal value,but also has a potential edible resource.However,limited by people's understanding of the nutritional value of C.officinalis,few product types and incomplete processing technology,people's acceptance of the edible value of C.oficinalis is not high,and it needs to be further developed and utilized. 展开更多
关键词 Cornus officinalis Active ingredients Biological activity Mechanism
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Study on the reaction kinetics mechanism and properties of RDX/ADN/FKM2602 composite microspheres 认领 引用 被引量：1
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作者 Cenlin Pan Zhenhua Liu +5 位作者 Yubing Zhao Ning Liu Taixing Liang Xiaodong Li Jingyu Wang Xiaofeng Shi 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第6期131-140,共10页
This study prepared a class of RDX-based composite microspheres(RAF)containing ADN and FKM2602.The reaction kinetics of RAF composite microspheres were effectively improved by maintaining the system's high energy ... This study prepared a class of RDX-based composite microspheres(RAF)containing ADN and FKM2602.The reaction kinetics of RAF composite microspheres were effectively improved by maintaining the system's high energy and safety performance.In the close packing state,when the heating rate is rapid,the thermal stability of RAF composite microspheres is better than that of RDX;the close packing state will reduce the degree of freedom of RDX and ADN reaction but will increase the degree of freedom of RAF composite microsphere reaction.The thermal conductivity of RAF composite microspheres is close to that of RDX.In the ignition experiment,the flame of RAF composite microspheres can be maintained without the external heat source.Regarding safety,the H50of RAF composite microspheres was 274.04%higher than that of RDX.The detonation velocity of RAF composite microspheres is slightly higher than that of raw material RDX.Overall,these findings highlight the effectiveness of ADN in enhancing the reaction kinetics of RDX-based composites. 展开更多
关键词 RDX Thermal analysis kinetics Model reconstruction Thermal conductivity
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Full-length transcriptome sequencing provides insights into chlorogenic acid biosynthesis in Lonicera japonica 认领 引用
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作者 Peng Zhang Tongyao Duan +5 位作者 Qidong Li Luyao Huang Zhenhua Liu Jia Li Zhilong Bao Fangfang Ma 《Ornamental Plant Research》 2025年第1期133-143,共11页
Lonicera japonica Thunb.is a significant medicinal resource within traditional Chinese medicine,exhibiting a variety of pharmacological properties.Previous studies reported that the major bioactive compound in L.japon... Lonicera japonica Thunb.is a significant medicinal resource within traditional Chinese medicine,exhibiting a variety of pharmacological properties.Previous studies reported that the major bioactive compound in L.japonica was chlorogenic acid(CGA),while the mechanism of CGA biosynthesis remained unknown due to the limited genome information.In the present study,PacBio single molecule real-time(SMRT)sequencing technology was employed to conduct the inaugural full-length transcriptome sequencing of the honeysuckle cultivar'Huajin 6'.A total of 97,588 high-quality transcripts,with an average length of 2,883 base pairs,were generated and annotated using the NR,GO,KOG,and KEGG databases.The coding sequences(CDS),transcription factors,simple sequence repeats(SSR),and long non-coding RNA(lncRNA)transcripts were predicted.The key genes encoding hydroxycinnamoyl-CoA quinate transferase(HQT)in CGA biosynthesis were isolated through the combination analysis of transcriptomic data and CGA content in flowers at different development stages.MYB genes that potentially regulated the transcription of HQT were further identified.Taken together,these results provide valuable genetic resources to assist the molecular study of L.japonica genes,which will facilitate the quality improvement of L.japonica cultivars. 展开更多
关键词 full length transcriptome sequencing Pacbio SMRT sequencing chlorogenic acid biosynthesis chlorogenic acid cga Huajin lonicera japonica bioactive compound hydroxycinnamoyl CoA quinate transferase
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MnO2 cathode materials with the improved stability via nitrogen doping for aqueous zinc-ion batteries 认领 引用 被引量：24
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作者 Yanan Zhang Yanpeng Liu +7 位作者 Zhenhua Liu Xiaogang Wu Yuxiang Wen Hangda Chen Xia Ni Guohan Liu Juanjuan Huang Shanglong Peng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第1期23-32,I0002,共10页
The research and exploration of manganese-based aqueous zinc-ion batteries have been controversial of cycle stability and mechanism investigation,thus improving the stability and exploring storage mechanism are still ... The research and exploration of manganese-based aqueous zinc-ion batteries have been controversial of cycle stability and mechanism investigation,thus improving the stability and exploring storage mechanism are still the most main issue.Defect engineering has become an effective method to improve cycle stability.Herein,a nitrogen-doped ε-MnO2(MnO2@N)has been prepared using electrochemical deposition and heat treatment under nitrogen atmosphere.As the cathode for zinc-ion batteries,the capacity retention rate of MnO2@N cathode is close to 100%after 500 cycles at 0.5 A g-1,while the capacity retention rate for the initial MnO2 cathode is 62%.At 5 A g-1,the capacity retention rate of MnO2@N cathode is 83%after 1000 cycles,which is much higher than the 27%capacity retention rate for the original MnO2 cathode.And it can be found that the oxygen vacancies increase after nitrogen doping,which can improve the conductivity of the MnO2@N cathode.Also,there is Mn-N bond in MnO2@N,which can enhance the electrochemical stability of MnO2@N cathode.In addition,the electrochemical mechanism of MnO2@N cathode has been explored by the CV,GCD and GITT tests.It is found that nitrogen doping promotes the intercalation of H+ and the corresponding capacity contribution.Compared with the original MnO2 cathode,the diffusion coefficient of H+ and Zn2+ in MnO2@N cathode increases.Also,the reactions during the charging and discharging process are explored through the ex-situ XRD test.And this work may provide some new ideas for improving the stability of manganese-based zinc-ion batteries. 展开更多
关键词 Manganese oxide Nitrogen doped Oxygen vacancy Reaction mechanism
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Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method 认领 引用 被引量：10
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作者 Changqin Li Yiping Cui +5 位作者 Jie Lu Lijun Meng Changyang Ma Zhenhua Liu Yan Zhang Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS CSCD 2021年第3期278-288,共11页
This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network mode... This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy.Then the target compounds were identified by high resolution mass spectrometry.The results indicated that there are both enhanced immunity and immunosuppressive components in G.lucidum.BP neural network was trained with the common peak area and immune effi cacy index of G.lucidum fi ngerprint as samples,and a combined evaluation system of G.lucidum fi ngerprint effi cacy was established.The correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal range.Eight compounds were identifi ed by high resolution mass spectrometry.The compounds related to immune activity in G.lucidum were determined in this study. 展开更多
关键词 Ganoderma lucidum RAW 264.7 cell Spectrum-effect relationships Component knock-out BP neural network
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Antioxidant activity and total phenolic content of essential oils and extracts of sweet basil(Ocimum basilicum L.)plants 认领 引用 被引量：10
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作者 Adel F.Ahmed Fatma A.K.Attia +3 位作者 Zhenhua Liu Changqin Li Jinfeng Wei Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS 2019年第3期299-305,共7页
The present study was conducted to evaluate the chemical composition and antioxidant activity of the essential oils and ethanol extracts of Ocimum basilicum L.obtained from Assiut,Minia and BeniSuef of Egypt.The major... The present study was conducted to evaluate the chemical composition and antioxidant activity of the essential oils and ethanol extracts of Ocimum basilicum L.obtained from Assiut,Minia and BeniSuef of Egypt.The major constituents of sweet basil essential oils from three locations were linalool,estragole,methyl cinnamate,bicyclosesquiphellandrene,eucalyptol,-bergamotene,eugenol,-cadinene and germacrene D by the method of GC–MS.The relative concentration of these compounds varies.The basil extracts contained appreciable levels of total phenolic contents and exhibited good DPPH radical scavenging capacity higher than that of essential oils.The highest TPC(82.45 mg PE/g)and maximum radical scavenging activity with IC50 value(1.29 mg/mL)was obtained from Minia basil extract.High correlation between antioxidant activity and total phenolic contents of basil extracts was observed.High variation in free radical scavenging activity of essential oils was found.The essential oil from Minia basil showed high activity in DPPH radical scavenging with IC50(11.23 mg/mL)and contained the highest content of phenolic(41.3 mg PE/g).On contrary,low correlation between antioxidant activity and total phenolic contents of basil essential oils from different locations.The results of the present investigation demonstrated significant variations in the antioxidant activities of sweet basil essential oils and extracts from Egypt. 展开更多
关键词 Ocimum basilicum Essential oils GC–MS Total phenolic contents Antioxidant activities
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Antioxidant andα-glucosidase inhibitiory activity of Cercis chinensis flowers 认领 引用 被引量：7
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作者 Juanjuan Zhang Li Zhou +3 位作者 Lili Cui Zhenhua Liu Jinfeng Wei Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS 2020年第4期313-319,共7页
Antioxidant andα-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method.Ethyl acetate fraction(CLEa)and n-butanol fraction(CLBu)exhibited antioxidant and... Antioxidant andα-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method.Ethyl acetate fraction(CLEa)and n-butanol fraction(CLBu)exhibited antioxidant andα-glucosidase inhibitiory activity in vitro,and the corresponding active fractions,EaFr.3,EaFr.5 and BuFr.1,exhibited higher antioxidant andα-glucosidase inhibitiory activity than those of other fractions.Eight compounds,ethyl gallate(1),stearic acid(2),docosanoic acid(3),5α-stigmast-9(11)-en-3β-ol(4),kaempferol-3-O-α-rhamnopyranoside(5),vanillic acid(6),fisetin(7),andβ-sitosterol(8),were isolated and identified from CLEa and CLBu.Ethyl gallate shown the highest antioxidant activity by scavenging DPPH radical and reducing ferric compared.Docosanoic acid and vanillic acid shown strongerα-glucosidase inhibitory activity than that of acarbose. 展开更多
关键词 Antioxidative activity Cercis chinensis bunge Chemical component α-glucosidase
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Natural products:Regulating glucose metabolism and improving insulin resistance 认领 引用 被引量：6
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作者 Fatma S.A.Saadeldeen Yun Niu +7 位作者 Honglin Wang Li Zhou Lijun Meng Sitan Chena Dongxiao Sun-Waterhouse Geoffrey Ivan Neil Waterhouse Zhenhua Liu Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS 2020年第3期214-228,共15页
Compounds with regulating glucose metabolism and improving insulin resistance(IR)activity are abundant in nature and can be obtained from several sources.They have high potential to be used to treat diabetes mellitus.... Compounds with regulating glucose metabolism and improving insulin resistance(IR)activity are abundant in nature and can be obtained from several sources.They have high potential to be used to treat diabetes mellitus.These compounds isolated from natural plants can be classified seven categories:terpenoids,alkaloids,quinones,flavonoids,phenols,phenyl propanoids,steroids,and other types of compounds.They exert biological effects by different ways and mechanisms.This review illustrated the potential natural products as a rich resource in regulation of glucose metabolism and IR,as well as their mechanisms. 展开更多
关键词 Natural products Glucose metabolism Insulin resistance(IR)
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Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation 认领 引用 被引量：3
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作者 Zhenhua Liu Xiaoqing Xu +5 位作者 Zhenhua Liang Yixiao Chen Qiuyi Wang Wenyi Kang Yan Zhang Bin Cong 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第6期3159-3170,共12页
Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes.Therefore,it is crucial to identify therapeutic agents that can alleviate insulin resistance by targetin... Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes.Therefore,it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation.Here,we present evidence that Bakuchiol(BL),a monoterpene phenolic compound first discovered from Psoralea corylifolia L.as traditional Chinese medicine,can effectively improve insulin resistance in diabetic mice through anti-inflammation.Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4uclear factorκB/mitogen-activated protein kinase axis,consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substrate1 pathway and improving glucolipid homeostasis.Furthermore,the insulin recovery achieved with BL(60 mg/kg)was comparable to that of metformin(200 mg/kg).These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus. 展开更多
关键词 Bakuchiol Diabetes Insulin resistance Proteomic Inflammation
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Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. flowers 认领 引用 被引量：5
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作者 Lili Cui Jinmei Wang +4 位作者 Mengke Wang Baoguang Wang Zhenhua Liu Jinfeng Wei Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS 2020年第2期124-129,共6页
Ligustri lucidi Fructus is a traditional Chinese medicine and possesses various bioactivities,including hypoglycemic effect.Ligustrum lucidum Ait flowers are poorly investigated.Thus,we hypothesized that L.lucidum flo... Ligustri lucidi Fructus is a traditional Chinese medicine and possesses various bioactivities,including hypoglycemic effect.Ligustrum lucidum Ait flowers are poorly investigated.Thus,we hypothesized that L.lucidum flowers also could have hypoglycemic effect.Chemical composition and glucose uptake effect of L.lucidum flowers on 3T3-L1 adipocytes were investigated.In this study,the components of L.lucidum flowers were investigated by various chromatographic and spectroscopic methods and the effects of L.lucidum flowers on the induction of glucose uptake were investigated by 3T3-L1 adipocytes.Seven compounds were isolated and identified from L.lucidum flowers,including ursolic acid(1),kaempferol-7-O-α-Lrhamnoside(2,KR),β-sitosterol(3),β-daucosterol(4),kaempferitrin(5,KF),10-hydroxy oleuropein(6,HO),and kaempferol-3-O-β-D-glucopyranoside-7-α-L-rhamnopyranoside(7,KGR).The results of glucose uptake showed that total extract(TE),KR,KF and HO from L.lucidum flowers significantly enhanced glucose uptake.This study demonstrated that compounds 2,5-7 were isolated for the first time from this plant and compounds 2 and 7 were isolated for the first time in genus Ligustrum,L.lucidum flowers,KR,KF and HO may possess potential hypoglycemic effect. 展开更多
关键词 Ligustrum lucidum flowers Chemical composition 3T3-L1 adipocytes
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Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression 认领 引用 被引量：2
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作者 Zhenhua Liu Mengke Wang +5 位作者 Lijun Meng Yixiao Chen Qiuyi Wang Yan Zhang Xuefeng Xi Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第6期2014-2021,共8页
Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on... Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on chemical constituents and hypoglycemic activity of P.scabiosaefolia,4 lignan compounds,(+)-isolariciresinol(1),7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside(2),4-O-methylcedrusin(3)and patrinian A(4),were isolated and identifi ed.The hypoglycemic activity showed that compounds 2 and 3 could extremely signifi cantly improve insulin resistance at 100(P<0.001),50(P<0.001)and 25μmol/L(P<0.01)in IR 3T3-L1 cells.While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100μmol/L(P<0.01).Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS,PI-3K,p-AKT and glucose transporter 4(GLUT4),and promoted the transcription of GLUT4 mRNA.Therefore,the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway. 展开更多
关键词 Patrinia scabiosaefolia Insulin resistance Patrinian A 7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside
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Ion diffusion,and hysteresis of magnesium hydride conversion electrode materials 认领 引用 被引量：1
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作者 Yingtong Lv Xiang Zhang +6 位作者 Wei Chen Shunlong Ju Zhenhua Liu Guanglin Xia Takayuki Ichikawa Tengfei Zhang Xuebin Yu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第24期47-53,共7页
MgH2,owing to a high theoretical capacity of 2038 mAh g−1,is regarded as a promising anode material for lithium-ion batteries(LIBs).However,the application of MgH2 is still far from satisfactory due to its po... MgH2,owing to a high theoretical capacity of 2038 mAh g−1,is regarded as a promising anode material for lithium-ion batteries(LIBs).However,the application of MgH2 is still far from satisfactory due to its poor cycling stability.Herein,nano-crystallization of MgH2 as an anode is applied for all-solid-state lithium-ion batteries(ASSLIBs)using LiBH4 as a solid-state electrolyte.The self-assembly designed MgH2 electrode on graphene could effectively alleviate the volume expansion,prevent the agglomeration of active substances,improve the electron transfer,and enhance the electrochemical performance of the anode material.As a result,a reversible capacity of 1214 mAh g−1 after 50 cycles is obtained.Significantly enhanced cycle life with a notable capacity of 597 mAh g−1 at a current density of 400 mA g−1 is delivered after 200 cycles.Further investigation on full cells also exhibits great application potential on ASSLIBs. 展开更多
关键词 Magnesium hydride Lithium borohydrides Graphene Nano-crystallization All-solid-state lithium-ion battery
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Application and prospects of proteomic technology in inflammation:a review 认领 引用
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作者 Senye Wang Yanhai Chu +4 位作者 Jiajia Yuan Yiqi Li Zhenhua Liu Xiaoyu Chen Wenyi Kang 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2373-2385,共13页
Proteomics is a new technology that has been widely applied in the field of life and health science.It effectively addresses issues related to the impact of dietary structure on organs,tissues,and cells,as well as the... Proteomics is a new technology that has been widely applied in the field of life and health science.It effectively addresses issues related to the impact of dietary structure on organs,tissues,and cells,as well as the changes in proteins in various organs,tissues,and cells under disease conditions.The differential proteins identified through proteomics can serve as disease biomarkers and target proteins affecting health and can be used for disease diagnosis and health regulation.In this paper,the application of proteomics in the field of infl ammation in recent years was summarized,especially in the therapeutic target and mechanism of action,which opens up a new way for more effective prevention,diagnosis,and treatment of inflammation,and provides medical protection for human life and health. 展开更多
关键词 Proteomics technology Inflammation Biomarkers Potential target Signaling pathway
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Effects of the Solution Treatment on Microstructural Evolution, Mechanical Properties, and Fracture Mechanism of Nickel-Based GH4099 Superalloy 认领 引用 被引量：6
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作者 Guangsheng Xu Chuan Wu +4 位作者 Zhenhua Liu Yilong Wang Zhanying Zhang Yun Li Ping Hu 《Journal of Minerals and Materials Characterization and Engineering》 2021年第6期566-589,共24页
Grain growth, mechanical properties, and fracture mechanism of nickel-based GH4099 superalloy are investigated using heat treatments, tensile tests, optical microscopy (OM), and scanning electron microscopy (SEM) with... Grain growth, mechanical properties, and fracture mechanism of nickel-based GH4099 superalloy are investigated using heat treatments, tensile tests, optical microscopy (OM), and scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS). The OM observation shows that the matrix grains (γ-grains) undergo an apparent growth during the solution treatment. The grain size diameter increases from 100 to 174 μm when the solution temperature rises from 1100℃ to 1160℃ for 30 min. When the holding time increases from 15 to 60 min at 1140℃, the grain size diameter increases from 140 to 176 μm, indicating that the γ-grain growth is more sensitive to temperature than time. Standard deviation, Sv, and the grain size distribution are utilized to characterize the microstructural uniformity. To predict the grain size more accurately, we develop the grain growth kinetics and find that the growth index is close to 5. The yield strength (Rp0.2), tensile strength (Rm), and ductility (Af) are also measured. It is found that the effect decreases in the order cooling rate, solution temperature, time. Rp0.2 reduces by 47% with the increase in the cooling rate from 1℃ to 8000℃/min, while both strength and ductility exhibit little changes with time. The SEM results show that the fracture surfaces have typical mixed brittle and ductile characteristics when specimens are subjected to water quenching and air cooling. However, a complete brittle fracture occurs under furnace cooling conditions. The EDS analysis indicates that the brittle γ' (Ni3Ti) phase precipitates around the γ-grain boundary during the slow cooling process, which is the main factor yielding the complete brittle fracture. Finally, the optimal solution treatment scheme for the GH4099 superalloy is proposed—a temperature of 1140℃ for 30 min followed by air cooling. 展开更多
关键词 Microstructural Evolution Mechanical Properties Fracture Mechanism GH4099 Nickel-Based Superalloy
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Advances in Research on Cellulose-based Drug Carriers 认领 引用 被引量：1
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作者 Miaoxiu Yang Yanrou Zhang +3 位作者 Zhenhua Liu Lina Liu Xin Wang Liwei Qian 《Paper And Biomaterials》 CAS 2023年第4期55-68,共14页
Traditional drug delivery methods are prone to large fluctuations in drug concentration and require multiple frequent doses.As a green material with excellent properties,cellulose has been widely used as a drug carrie... Traditional drug delivery methods are prone to large fluctuations in drug concentration and require multiple frequent doses.As a green material with excellent properties,cellulose has been widely used as a drug carrier for the development and preparation of drug controlled-release system.Based on the mechanisms of slow drug release,such as dissolution-diffusion release,degradation release,and nanochannel-controlled release,the preparation methods of cellulose-based drug carriers are introduced in this paper.The applications of cellulose-based drug carriers in the fields of antitumor therapy,antibacterial therapy,chronic disease treatment,and viral disease treatment are summarized with the aim of providing a useful reference for research on cellulose-based drug carriers. 展开更多
关键词 cellulose drug carrier drug controlled-release
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Research Progress on Material Basis,Pharmacological Effect and Clinical Application of Danggui Shaoyao Powder 认领 引用 被引量：1
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作者 Lanqingqing ZHAO Na LI +5 位作者 Zhe LI Jinxin LIU Yongzhou YU Haifeng PAN Zhenhua LIU Hui XIONG 《Medicinal Plant》 2021年第5期84-89,共6页
The research of modern pharmacology displays that main material basis of Danggui Shaoyao Powder exerting efficacy includes ligustilide,paeoniflorin,poria acid,ferulic acid,ligustrazine and so on,and its efficacy is ma... The research of modern pharmacology displays that main material basis of Danggui Shaoyao Powder exerting efficacy includes ligustilide,paeoniflorin,poria acid,ferulic acid,ligustrazine and so on,and its efficacy is mainly realized by regulating neural receptor-ligand interaction,cytokine release,and TNF-αinflammatory pathway.Systematic study of metabonomics,serum pharmacochemistry and network pharmacology of Danggui Shaoyao Powder sufficiently clarifies its potential pharmacodynamic mechanism,and it could provide scientific theoretical basis for its clinical application.In this paper,by systemically analyzing material basis of Danggui Shaoyao Powder,and exploring its complex pharmacological mechanism and clinical application in vivo,it could comprehensively understand the clinical value of Danggui Shaoyao Powder,so as to provide beneficial reference for further development of the material basis,quality control and classical prescription of Danggui Shaoyao Powder. 展开更多
关键词 Danggui Shaoyao Powder Material basis Pharmacological effect Clinical application
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