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Dynamic failure risk of coal pillar formed by irregular shape longwall face:A case study 认领 引用 被引量：5
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作者 Yixin Zhao Hao Wang +2 位作者 Shimin Liu Zonglong Mu Zhiguo Lu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2018年第5期775-781,共7页
Irregular shape workface would result in the presence of coal pillar, which leads to high stress concentration and possibly induces coal bumps. In order to study the coal bump mechanism of pillars, static and dynamic ... Irregular shape workface would result in the presence of coal pillar, which leads to high stress concentration and possibly induces coal bumps. In order to study the coal bump mechanism of pillars, static and dynamic stress overlapping(SDSO) method was proposed to explain the impacts of static stress concentration and tremors induced by mining activities. The stress and deformation in surrounding rock of mining face were analyzed based on the field case study at 1303 workface in Zhaolou Coal Mine in China.The results illustrate that the surrounding rock of a workface could be divided into four different zones,i.e., residual stress zone, stress decrease zone, stress increase zone and original stress zone. The stress increase zone is prone to failure under the SDSO impact loading conditions and will provide elastic energy for inducing coal bump. Based on the numerical modelling results, the evolution of static stress in coal pillar as the size of gob increasing was studied, and the impact of dynamic stress was investigated through analyzing the characteristics of tremor activities. The numerical results demonstrate the peak value of vertical stress in coal pillar rises from about 30 MPa with mining distance 10 m to 52.6 MPa with mining distance 120 m, and the location of peak stress transfers to the inner zone of coal pillars as the workface moves forward. For the daily tremor activities, tremors with high energy released indicate high dynamic stress disturbance on the surrounding rock, therefore, the impact of dynamic stressing is more serious during workface extension period because the tremor frequency and average energy after workface extension are higher than those before the workface extension. 展开更多
关键词 Coal bump Coal pillar Tremor Irregular shape longwall face Static and dynamic stress overlapping
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A Walk Primitive with Double Support for Biped Robots 认领 引用 被引量：1
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作者 Guoshuai Liu Zhiguo Lu +2 位作者 Zhongqing Li Jin Xuan Aizun Liu 《Journal of Bionic Engineering》 SCIE EI CSCD 2025年第1期133-143,共11页
Walking is the basic locomotion pattern for bipedal robots.The walking pattern is widely generated using the linear inverted pendulum model.The linear inverted pendulum motion of each support period can be designed as... Walking is the basic locomotion pattern for bipedal robots.The walking pattern is widely generated using the linear inverted pendulum model.The linear inverted pendulum motion of each support period can be designed as a walk primitive to be connected to form a walking trajectory.A novel method of integrating double support phase into the walk primitive was proposed in this article.The method describes the generation of walking patterns using walk primitives with double support,specifically for lateral plane including walking in place,walking for lateral,and walking initiation,and for sagittal plane including fixed step length walking,variable step length walking,and walking initiation.Compared to walk primitives without double support phase,those with double support phase reduce the maximum speed required by the robot and eliminate the need to adjust foothold for achieving continuous speed.The performance of the proposed method is validated by simulations and experiments on Neubot,a position-controlled biped robot. 展开更多
关键词 Biped robot Linear inverted pendulum Walk primitive Double support
The genome of Hibiscus hamabo reveals its adaptation to saline and waterlogged habitat 认领 引用 被引量：9
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作者 Zhiquan Wang Jia-Yu Xue +12 位作者 Shuai-Ya Hu Fengjiao Zhang Ranran Yu Dijun Chen Yves Van de Peer Jiafu Jiang Aiping Song Longjie Ni Jianfeng Hua Zhiguo Lu Chaoguang Yu Yunlong Yin Chunsun Gu 《Horticulture Research》 SCIE CSCD 2022年第1期1360-1373,共14页
Hibiscus hamabo is a semi-mangrove species with strong tolerance to salt and waterlogging stress.However,the molecular basis and mechanisms that underlie this strong adaptability to harsh environments remain poorly un... Hibiscus hamabo is a semi-mangrove species with strong tolerance to salt and waterlogging stress.However,the molecular basis and mechanisms that underlie this strong adaptability to harsh environments remain poorly understood.Here,we assembled a highquality,chromosome-level genome of this semi-mangrove plant and analyzed its transcriptome under different stress treatments to reveal regulatory responses and mechanisms.Our analyses suggested that H.hamabo has undergone two recent successive polyploidy events,a whole-genome duplication followed by a whole-genome triplication,resulting in an unusually large gene number(107309 genes).Comparison of the H.hamabo genome with that of its close relative Hibiscus cannabinus,which has not experienced a recent WGT,indicated that genes associated with high stress resistance have been preferentially preserved in the H.hamabo genome,suggesting an underlying association between polyploidy and stronger stress resistance.Transcriptomic data indicated that genes in the roots and leaves responded differently to stress.In roots,genes that regulate ion channels involved in biosynthetic and metabolic processes responded quickly to adjust the ion concentration and provide metabolic products to protect root cells,whereas no such rapid response was observed from genes in leaves.Using co-expression networks,potential stress resistance genes were identified for use in future functional investigations.The genome sequence,along with several transcriptome datasets,provide insights into genome evolution and themechanism of salt and waterlogging tolerance in H.hamabo,suggesting the importance of polyploidization for environmental adaptation. 展开更多
关键词 polyploidy eventsa genome transcriptome gene duplication stress treatments salt tolerance hibiscus hamabo polyploidy
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Numerical analysis on the factors affecting post-peak characteristics of coal under uniaxial compression 认领 引用 被引量：7
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作者 Zhiguo Lu Wenjun Ju +1 位作者 Fuqiang Gao Taotao Du 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第1期42-60,共19页
The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability.Understanding the significant factors that influ... The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability.Understanding the significant factors that influence post-peak characteristics can offer valuable insights for the prevention of coal bursts.In this study,the Synthetic Rock Mass method is employed to establish a numerical model,and the factors affecting coal post-peak characteristics are analyzed from four perspectives:coal matrix mechanical parameters,structural weak surface properties,height-to-width ratio,and loading rate.The research identifies four significant influencing factors:deformation modulus,density of discrete fracture networks,height-to-width ratio,and loading rate.The response and sensitivity of post-peak characteristics to single-factor and multi-factor interactions are assessed.The result suggested that feasible prevention and control measures for coal bursts can be formulated through four approaches:weakening the mechanical properties of coal pillars,increasing the number of structural weak surfaces in coal pillars,reducing the width of coal pillars,and optimizing mining and excavation speed.The efficacy of measures aimed at weakening the mechanical properties of coal is successfully demonstrated through a case study on coal burst prevention using large-diameter borehole drilling. 展开更多
关键词 Post-peak behavior Synthetic rock mass Coal bursts Coal burst prevention
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Reactive nano-essential oils for sustained release of essential oils and application to wallpaper 认领 引用 被引量：4
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作者 Qiulian Hao Huan Peng +9 位作者 Ruichen Zhao Jianze Wang Zhiguo Lu Jingwen Wang Jie Shen Yunwei Niu Zuobing Xiao Guiying Liu Jifu Hao Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第1期320-323,共4页
Essential oils are a volatile and aromatic substance with a variety of active biological activities.However,the excessive volatility and inconvenience of the use of essential oils limit their applications.In this stud... Essential oils are a volatile and aromatic substance with a variety of active biological activities.However,the excessive volatility and inconvenience of the use of essential oils limit their applications.In this study,we developed a reactive mesoporous silica nanoparticle(rMSNs)based on cyanuric chloride modification for essential oil encapsulation and commodity adhesion.The large pore volume and specific surface area of rMSNs facilitate the nanoparticles adhering to a large amount of essential oil and achieve the sustained release of essential oil,thus prolonging the fragrance retention time of essential oils.The reactive nanoessential oils can form covalent bonds with the wallpaper,thereby remarkably improving the adhesion of the reactive nano-essential oils on the wallpaper and preventing the reactive nano-essential oil from deadhering from the wallpaper.The active nano essential oil simultaneously overcomes the intense volatility of the essential oil and inconvenience in use,has a simple preparation process and low cost,and has great application potential. 展开更多
关键词 Reactive nano-essential oils Reactive mesoporous silica nanoparticles Slow-release of essential oils Application to wallpaper Covalent bonds
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Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol 认领 引用 被引量：4
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作者 Tianlu Zhang Zhiguo Lu +8 位作者 Jianze Wang Jie Shen Qiulian Hao Yan Li Jun Yang Yunwei Niu Zuobing Xiao Lei Chen Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第5期1755-1758,共4页
Fragrances are frequently added to a variety of products,including food,cosmetics and health products.However,the high volatility and instability of essence limit its application in some fields.In this study,mesoporou... Fragrances are frequently added to a variety of products,including food,cosmetics and health products.However,the high volatility and instability of essence limit its application in some fields.In this study,mesoporous silica nanoparticles(MSNs) were prepared to encapsulate eugenol,which could reduce the volatilization of the fragrance molecules.A facile approach was presented to synthesize MSNs with three different pore diameters for encapsulating eugenol.In addition,the properties of MSNs including mean particle size,morphology,encapsulating efficiency and release tendency were charac terized.Results showed that the larger the pore diameters of MSNs,the more aromatic molecules were adsorbed.Furthermore,the release mechanism was described as the smaller the pore diameters of MSNs,the slower the release of eugenol. 展开更多
关键词 Eugenol Mesoporous silica nanoparticles Nano-fragrance Slow release of fragrance
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Zwitterionic comb-like lipid polymers encapsulating linalool for increasing the fragrance retention time 认领 引用 被引量：2
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作者 Tianlu Zhang Zhiguo Lu +5 位作者 Xiangyu Wang Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期573-576,共4页
Fragrances are widely used in cosmetics,apparel and detergents.However,the rapid evaporation of the aro ma shortens the useful life of the aromatic product.Therefore,improving the fragrance retention time of aromatic ... Fragrances are widely used in cosmetics,apparel and detergents.However,the rapid evaporation of the aro ma shortens the useful life of the aromatic product.Therefore,improving the fragrance retention time of aromatic products and prolonging the service life of aromatic products are the key scientific problems that need to be solved in current aromatic products.In this study,zwitterionic comb-like lipid polymers were synthesized to encapsulate the fragrance molecule linalool.The results showed that the zwitterionic comb lipid molecules were capable of encapsulating more linalool than linear lipid molecules.At the same time,the zwitterionic comb-like lipid molecules also limited the slow release rate of the aroma,thereby increasing the fragrance retention time of the nano-fragrance. 展开更多
关键词 Linalool Zwitterionic comb-like lipid polymers Nano-fragrance Fragrance retention time Slow release
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Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance 认领 引用 被引量：2
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作者 Weihong Ji Tianlu Zhang +3 位作者 Zhiguo Lu Jie Shen Zuobing Xiao Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第3期739-742,共4页
Fragranced products are wildly used in our daily life. However, their storage, application and quality are severely influenced by their strong volatility. In order to overcome these natural defects of fragrances,fragr... Fragranced products are wildly used in our daily life. However, their storage, application and quality are severely influenced by their strong volatility. In order to overcome these natural defects of fragrances,fragrance encapsulation approaches have been developed recently. In this study, a mild, simple and lowcost method of fragrance encapsulation was invented. Liposomes composed of soya lecithin/DSPEPEG2000/PLGA were prepared to encapsulate lily fragrance(LF). And these nanosized fragrance products was named LF-NPs. The hydrodynamic diameters of LF-NPs were approximately 100 nm and their encapsulation efficiency was up to 21.9%. Besides, LF-NPs could also prolong the release time of lily fragrance. Finally, the cytotoxicity tests indicated that LF-NPs offered biocompatibility. Therefore, LF-NPs were expected to have application prospects. 展开更多
关键词 Nanocapsules Encapsulation Fragrance Biocompatibility Simple operation
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Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper 认领 引用 被引量：1
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作者 Weihong Ji Tianlu Zhang +5 位作者 Zhiguo Lu Jie Shen Jing Hu Yunwei Niu Zuobing Xiao Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第3期747-749,共3页
Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and... Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and quality. Therefore, it is necessary and urgent to develop approaches to controllably release the odorants as demanded. In this study, photo-driven mesoporous silica nanospheres loaded with sandela 803 was designed, prepared and named as S803@MS-S. S803@MS-S possessed ordered mesoporous, large specific surface area and pore volume. After adsorption of sandela 803, the S803@MSS was added into wallpaper to prepare fragrant wallpaper S803@MS-S-W. And this wallpaper exhibited excellent sustained and controlled release performances stimulated by light. 展开更多
关键词 Mesoporous silica nanospheres Sandela 803 Photo-driven release Wallpaper Azobenzene derivatives
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Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk 认领 引用
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作者 Zhiguo Lu Xiangyu Wang +9 位作者 Tianlu Zhang Luyao Zhang Jun Yang Yan Li Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Guiying Liu Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第12期3139-3142,共4页
Silk has been widely used in the clothing industry due to their soft and smooth features,good biocompatibility,good heat dissipation,warmth and ultraviolet resistance.The application of fragrance to silk can significa... Silk has been widely used in the clothing industry due to their soft and smooth features,good biocompatibility,good heat dissipation,warmth and ultraviolet resistance.The application of fragrance to silk can significantly improve the performance of silk.However,there are two key scientific problems that need to be solved:slowing down the release rate of fragrances and increasing the scent lasting time of silk.In this study,cationic and temperature-sensitive liposomes were designed and prepared to encapsulate eugenol.These fragrance-loaded liposomes significantly slowed down the release rate of the fragrance and controlled the release rate of the fragrance in a thermo-sensitive manner.The liposomes adhered to the silk through electrostatic adsorption interaction.The positive charge on the fragranceloaded liposomes neutralized much negative charge on silk and thereby increasing the adhesion efficiency. 展开更多
关键词 Eugenol Silk Cationic and temperature-sensitive liposomes Slow release of fragrance Controlled release of fragrance
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Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol 认领 引用
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作者 Tianlu Zhang Zhiguo Lu +8 位作者 Luyao Zhang Yan Li Jun Yang Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Lei Chen Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第12期3135-3138,共4页
Fragrances are widely used in many aspects of our lives.They cannot only make people happy,but also treat many diseases.However,excessively fast evaporation rate is one of the main obstacles to the use of spices.In th... Fragrances are widely used in many aspects of our lives.They cannot only make people happy,but also treat many diseases.However,excessively fast evaporation rate is one of the main obstacles to the use of spices.In this study,mesoporous silica nanorods(MSNRs)and hollow mesoporous silica nanorods(HMSNRs)were prepared to encapsulate eugenol.These two nano-fragrances were named eugenol@MSNRs and eugenol@HMSNRs,respectively.The morphologies,size,interior structures and pore performances of MSNRs and HMSNRs.Besides,the performances of encapsulation and fragrance release of eugenol@MSNRs and eugenol@HMSNRs were compared and analyzed.The results showed that eugenol@HMSNRs encapsulated more fragrance and were faster to encapsulate compared with eugenol@MSNRs.Both the release rates of eugenol from eugenol@MSNRs and eugenol@HMSNRs were slow.But the eugenol was released from eugenol@MSNRs more slowly. 展开更多
关键词 Eugenol Hollow mesoporous silica nanorods Mesoporous silica nanorods Nano-fragrance Slow release of fragrance
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Electrochemical Identification of Yulania spp. by Fingerprinting of Leaves Using Glassy Carbon Electrode 认领 引用
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作者 Zhiguo Lu Yuhong Zheng +3 位作者 Pengchong Zhang Boyuan Fan Aimin Yu Li Fu 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第11期2549-2558,共10页
In this communication,we used electrochemical sensor for recording the electrochemical profiles of eleven species of Yulania spp.from leaf extract.Two solvents and two buffer conditions were used for electrochemical f... In this communication,we used electrochemical sensor for recording the electrochemical profiles of eleven species of Yulania spp.from leaf extract.Two solvents and two buffer conditions were used for electrochemical fingerprints collection.Their electrochemical fingerprints can be converted to different patterns and consequently for species recognition.The results indicate the pattern recognition is much convenient than that of the recognition of species directly using voltammetric signal.The current information in electrochemical fingerprinting represents the type and amount of electrochemically active molecules,which linked to the genetic differences among the plants.Therefore,the electrochemical fingerprints were applied for further phylogenetic study.The phylogenetic tree deduced from voltametric curves is divided into three main groups.The first clade contains Y.denudate,Liriodendron chinense,Y.cylindrica,Y.biondii,Y.sprengeri.The second clade contains Y.zenii,Y.liliiflora,Y.kobus,and Y.amoena.The third clade contains Y.×soulangeana,Manglietia fordiana and Y.sinostellata.In addition,Y.salicifolia is not in these main clades.The results demonstrate that electrochemical fingerprinting can be used as a com-plementary tool in the study of phylogenetics. 展开更多
关键词 Phylogenetic Yulania spp. plant identification fingerprints chemotaxonomy
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A Preliminary Study on Cold Tolerance in Cinnamomum japonicum Sieb. at Different Ages 认领 引用 被引量：1
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作者 Dongqin ZHOU Yuwu XIONG +3 位作者 Zhiguo LU Luwan HAN Ziyang WANG Yunlong YIN 《Agricultural Biotechnology》 2013年第6期24-28,共5页
[ Objective] This study aimed to further expand the production and application of Cirmamomumjaponicum Sieb. and investigate the mechanism of cold resistance in evergreen broad-leaved tree species. [ Method] Using adul... [ Objective] This study aimed to further expand the production and application of Cirmamomumjaponicum Sieb. and investigate the mechanism of cold resistance in evergreen broad-leaved tree species. [ Method] Using adult Cinnamonum campora as control, during the entire wintering period from October 2011 to March 2012, the wintering adaptability of C. japonicum leaves at different ages was observed; the electrolyte leakage was measured under indoor low-temperature treatment to calculate the semi-lethal temperature （LT50） by fitting Logistic equation, thus conducting dynamic analysis and comprehensive evaluation of the cold re- sistance in C. japonicum. [ Result] The results showed that the chilling injuries in leaves of different materials were aggravated with the decreasing temperature. According to the results of five times of dynamic observation on wintering adaptability, the cold resistance in different materials presented a decreasing order of adult C. japonicum medium-aged C. japonicum 〉 young C. japon/cum 〉 adult C. campora. The relationship between indoor low temperature and leaf injury rate showed an S-shaped curve. The significance test suggested relatively high fitting degree with Logistic equation. The semi-lethal temperature presented a V-shaped curve with the changing temperature and roached the minimum during late December to early February in the following year. The dynamic changes and minimum value of semi-lethal temperature indicated a consistent order of cold resistance in different materials to the results of wintering adaptability observation. Therefore, results of two analysis methods could be combined for cold resistance evaluation. [ Conclusion] This study laid the foundation for the introduction and populariza- tion of C. japonicum in northern gardens along the Yangtze River. 展开更多
关键词 Cinnamomumjaponicum Sieb. Cold tolerance LT50 Evergreen broad-leaved trees
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Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition 认领 引用 被引量：16
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作者 Zhiguo Lu Jianze Wang +9 位作者 Lina Qu Guanghan Kan Tianlu Zhang Jie Shen Yan Li Jun Yang Yunwei Niu Zuobing Xiao Yinghui Li Xin Zhang 《Bioactive Materials》 SCIE 2020年第4期1127-1137,共11页
Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can... Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently.However,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight.In this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene.The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy.LE@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the wallpaper.In the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity environment.The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in mice.LE@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated mice.Subsequently,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins. 展开更多
关键词 Reactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health
Smart antioxidant function enhancing(SAFE)nucleic acid therapy for ROS-related chronic diseases and comorbidities 认领 引用 被引量：3
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作者 Zhiguo Lu Ruichen Zhao +12 位作者 Yi Li Jianze Wang Jing Guo Chaobo Bai Jing Chen Jun Yang Yiwan Geng Tianlu Zhang Yanyue Wu Xiyue Jiao Yining Wang Junliang Yuan Xin Zhang 《Bioactive Materials》 SCIE CSCD 2024年第1期509-524,共16页
Reactive oxygen species(ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders.The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system... Reactive oxygen species(ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders.The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system.However,ROS under redox homeostasis regulates a wide range of life activities.Therefore,smart scavenging of excess ROS under pathological conditions is essential to treat chronic diseases safely.This study reports a smart antioxidant function enhancement(SAFE)strategy.On-demand release of nucleic acid drugs in a pathological ROS environment smartly activates the endogenous antioxidant system,thereby smartly alleviating oxidative stress in an exogenous antioxidant-independent manner.Through structural modulation and ligand modification,we develop SAFE nanoparticles based on nanohybrid complexes(SAFE-complex)adapted to brain delivery of nucleic acid drugs.SAFE-complex with homogeneous monodisperse structure efficiently treat ROS-related neurodegenerative diseases while protecting the major organ from oxidative stress damage.Moreover,SAFE-complex can stabilize storage in the form of freeze-dried powder.These data indicate that SAFE nanoparticles hold promise for treating ROS-related chronic diseases and comorbidities through rational transformation. 展开更多
关键词 Smart antioxidant function enhancing(SAFE)strategy Reactive oxygen species Nucleic acid drugs Keap1-Nrf2-ARE pathway ROS-Associated chronic diseases and comorbidities
A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments 认领 引用
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作者 Yanyue Wu Wenli Wang +9 位作者 Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang 《Nano Research》 SCIE EI CSCD 2023年第5期7216-7226,共11页
Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage... Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate diseases.Numerous studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory pathway.Therefore,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease treatments.Considering the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease treatments.The STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted microglia.The results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s disease.Herein,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies. 展开更多
关键词 sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease
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高分子纳米香精制备的研究进展 认领 引用 被引量：3
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作者 沈洁 卢红霞 +6 位作者 卢治国 张田露 朱为宏 江黎明 申有青 肖作兵 张欣 《中国科学：化学》 CAS CSCD 北大核心 2019年第4期591-596,共6页
香精是种类和功能多样的精细化学品,已经广泛应用于人们生活中.但因香精的主要成分为沸点低、易挥发的物质,所以存在留香时间短、对环境敏感的缺点,限制了其被广泛的应用.如何控制和减缓香料的挥发,稳定香精的性质是提高香精应用效率的... 香精是种类和功能多样的精细化学品,已经广泛应用于人们生活中.但因香精的主要成分为沸点低、易挥发的物质,所以存在留香时间短、对环境敏感的缺点,限制了其被广泛的应用.如何控制和减缓香料的挥发,稳定香精的性质是提高香精应用效率的难点和重点.目前,利用高分子材料将易挥发的香精纳米化,构建缓控释体系,可以有效解决上述问题.本文对高分子纳米香精的制备方法及其研究进展进行了综述. 展开更多
关键词 香精 纳米化 高分子 缓释 控释
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光敏纳米香料应用于壁纸及香气缓控释的研究 认领 引用 被引量：1
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作者 沈洁 卢红霞 +3 位作者 卢治国 张田露 肖作兵 张欣 《中国科学：化学》 CAS CSCD 北大核心 2019年第4期613-618,共6页
利用简单的溶胶-凝胶法制备了介孔二氧化硅纳米棒,并偶联小分子光敏剂ICPES-AZO.通过介孔二氧化硅吸附能力,对檀香803进行载香,制备出光敏性纳米香料.随后,将纳米香料附着在壁纸上,形成芳香壁纸.最后,对芳香壁纸上檀香803的释放进行了检... 利用简单的溶胶-凝胶法制备了介孔二氧化硅纳米棒,并偶联小分子光敏剂ICPES-AZO.通过介孔二氧化硅吸附能力,对檀香803进行载香,制备出光敏性纳米香料.随后,将纳米香料附着在壁纸上,形成芳香壁纸.最后,对芳香壁纸上檀香803的释放进行了检测.研究表明,光照条件下香料可以持续释放,黑暗条件下缓慢释放,具有显著的缓控释效果. 展开更多
关键词 檀香803 介孔二氧化硅 缓控释 芳香壁纸 纳米香料
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生物启发和生物工程核酸药物载体 认领 引用 被引量：4
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作者 左嘉敏 卢治国 +7 位作者 郭京 赵睿琛 张田露 王朝霞 袁云 邓健文 袁俊亮 张欣 《Science China Materials》 SCIE EI CAS CSCD 2024年第8期2393-2413,共21页
核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和... 核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和生物启发材料所具有的内源性递送生物大分子的能力来递送核酸药物.本文重点介绍核酸药物递送过程中需要克服的生物障碍,以及生物工程和生物启发材料在核酸药物递送中的优势和应用.通过利用这些先进的生物材料,研究人员有望提高核酸药物的疗效,为疾病治疗提供新的解决方案. 展开更多
关键词 生物工程 药物递送 生理障碍 生物启发 致病基因 生物大分子 工程化 疾病治疗
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