Pepper(Capsicum annuum L.)is highly susceptible to chilling stress,which severely constrains its growth and productivity.Although the eco-friendly biostimulantγ-polyglutamic acid(γ-PGA)has shown promise in enhancing...Pepper(Capsicum annuum L.)is highly susceptible to chilling stress,which severely constrains its growth and productivity.Although the eco-friendly biostimulantγ-polyglutamic acid(γ-PGA)has shown promise in enhancing plant tolerance to abiotic stresses,its specific role and underlying mechanisms in alleviating chilling injury in pepper remain poorly understood.This study systematically investigated the physiological and molecular mechanisms by which foliar application of 100 mg⋅L-1γ-PGA enhances chilling tolerance in pepper seedlings.Our results demonstrated thatγ-PGA pretreatment significantly mitigated chilling-induced growth inhibition and promoted root development,evidenced by a 110.8%increase in the number of root tips.Analysis of photosynthetic performance revealed thatγ-PGA effectively counteracted chilling-induced photosynthetic suppression,increasing the net photosynthetic rate(Pn)by 172.9%and the maximum photochemical efficiency of PSII(Fv/Fm)by 17.9%.Furthermore,γ-PGA treatment significantly reduced the accumulation of reactive oxygen species(O2·-and H2O2)and malondialdehyde(MDA)while promoting the synthesis of the osmoprotectant proline.This protective effect was associated with a strengthened antioxidant defense system;γ-PGA enhanced the activities of superoxide dismutase(SOD),catalase(CAT),and ascorbate peroxidase(APX).These changes were supported at the molecular level by the significant upregulation of their corresponding genes(CaSOD,CaCAT,and CaAPX),with CaAPX expression showing a striking 313.5%increase.In conclusion,foliar application ofγ-PGA enhances chilling tolerance in pepper seedlings via a multi-faceted mechanism that includes improving root architecture,reinforcing the antioxidant defense system,facilitating osmotic adjustment,and protecting the photosynthetic apparatus.These findings provide a theoretical framework and practical support for usingγ-PGA as an effective and sustainable biostimulant to improve pepper cultivation in environments prone to chilling stress.展开更多
The polymeric semiconductor photocatalyst graphitic carbon nitride(g-C3N4)has attracted considerable attention due to its visible-light responsiveness and excellent biocompatibility.However,the photocatalytic ef...The polymeric semiconductor photocatalyst graphitic carbon nitride(g-C3N4)has attracted considerable attention due to its visible-light responsiveness and excellent biocompatibility.However,the photocatalytic efficiency of bulk g-C3N4(CNB)remains insufficient for pratical applications,primarily due to its limited light absorption range and the rapid charge carrier recombination.In this study,K+-doped crystalline g-C3N4with cyano defects(CNK)was synthesized by the calcination of dicyandiamide in the presence of KCl.The addition of KCl promoted the formation of K+-doped crystalline g-C3N4with cyano defects.The optimized photocatalyst(CNK2)exhibits the highest photocatalytic activity for NO oxidation,achieving a removal rate of 47.40%,which is 2.1 times higher than that of CNB.This enhancement is mainly attributed to the increased generation of reactive oxygen species(ROS),particularly superoxide radicals(·O2-)and singlet oxygen(1O2).Furthermore,improved performance in photocatalytic CO2-to-CH4 conversion was also observed,which is attributed to the formation of a build-in electric field(BIEF)induced by K+ion doping and the introduction of cyano defects.展开更多
The ultrafast laser-matter interaction is explored to induce new pioneering principles and technologies into the realms of fundamental science and industrial production.The local thermal melting and connection propert...The ultrafast laser-matter interaction is explored to induce new pioneering principles and technologies into the realms of fundamental science and industrial production.The local thermal melting and connection properties of the ultrafast laser welding technology offer a novel method for welding of diverse transparent materials,thus having wide range of potential applications in aerospace,opto-mechanical systems,sensors,microfluidic,optics,etc.In this comprehensive review,tuning the transient electron activation processes,high-rate laser energy deposition,and dynamic evolution of plasma morphology by the temporal/spatial shaping methods have been demonstrated to facilitate the transition from conventional homogeneous transparent material welding to the more intricate realm of transparent/metal heterogeneous material welding.The welding strength and stability are also improvable through the implementation of real-time,in-situ monitoring techniques and the prompt diagnosis of welding defects.The principles of ultrafast laser welding,bottleneck problems in the welding,novel welding methods,advances in welding performance,in-situ monitoring and diagnosis,and various applications are reviewed.Finally,we offer a forward-looking perspective on the fundamental challenges within the field of ultrafast laser welding and identify key areas for future research,underscoring the imperative need for ongoing innovation and exploration.展开更多
Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in nonobstructive azoospermia(NOA),a severe form of male infertility.However,the precise mechanisms linking fatty...Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in nonobstructive azoospermia(NOA),a severe form of male infertility.However,the precise mechanisms linking fatty acid metabolism to NOA pathogenesis have not yet been fully elucidated.Multi-omics analyses,including microarray analysis,single-cell RNA sequencing(scRNA-seq),and metabolomics,were utilized to investigate disruptions in fatty acid metabolism associated with NOA using data from public databases.Results identified ACSL6,ACSBG2,and OLAH as key genes linked to fatty acid metabolism dysregulation,suggesting their potential causative roles in NOA.A marked reduction in omega-3 polyunsaturated fatty acids,especially docosahexaenoic acid(DHA),was observed,potentially contributing to the pathological process of NOA.Sertoli cells in NOA patients exhibited apparent fatty acid metabolic dysfunction,with PPARG identified as a key transcription factor(TF)regulating this process.Functional analyses demonstrated that PPARG is crucial for maintaining blood-testis barrier(BTB)integrity and promoting spermatogenesis via regulation of fatty acid metabolism.These findings reveal the pivotal role of fatty acid metabolism in NOA and identify PPARG as a potential therapeutic target.展开更多
This study examines the adaptive boundary control problem of flexible marine riser with internal flow coupling.The dynamic model of the flexible marine riser system with internal flow coupling is derived using the Ham...This study examines the adaptive boundary control problem of flexible marine riser with internal flow coupling.The dynamic model of the flexible marine riser system with internal flow coupling is derived using the Hamiltonian principle.An analysis of internal flow’s influence on the vibration characteristics of flexible marine risers is conducted.Then,for the uncertain environmental disturbance,the adaptive fuzzy logic system is introduced to dynamically approximate the boundary disturbance,and a robust adaptive fuzzy boundary control is proposed.The uniform boundedness of the closed-loop system is proved based on Lyapunov theory.The well-posedness of the closed-loop system is proved by operator semigroup theory.The proposed control’s effectiveness is validated through comparison with existing control methods.展开更多
Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could...Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could effectively alleviate drought-triggered leaf senescence and oxidative injury tocreeping bentgrass.Plants were exogenously irrigated with or without DA-6(0.4 mM·L-1)before being subjected to PEG-induced drought stress for 9 d.Drought stress resulted in significant growth retardation,Chl loss,and decreases in leaf relative water content,water use efficiency,photochemicalefficiency,and net photosynthetic rate,but significantly enhanced oxidative damage.Exogenous DA-6 markedly alleviated symptoms of drought stress byimproving water homeostasis,ROS scavenging,Chl biosynthesis,and photosynthesis.In contrast to untreated plants,the DA-6-pretreated creepingbentgrass demonstrated significantly higher transcript levels of genes related to rubisco activity(AsRuBisCo),and Chl biosynthesis(AsMg-CHT,AsPBGD,AsPOR,and AsCHLH),but lower transcript levels of Chl degradation-related genes(AsPAO,AsCLH,and AsPPH),and senescence-associated genes(Asl20 andAsh36),thereby decreasing leaf senescence and ameliorating photosynthetic performance under drought stress.Moreover,DA-6 also significantlypromoted activities of superoxide dismutase,peroxidase,catalase,and ascorbate peroxidase,hence efficiently diminishing drought-stimulated oxidativedamage.The current study supplies important information about DA-6-regulated growth and drought tolerance associated with osmotic adjustment,antioxidant defense,photosynthetic function,and Chl metabolism in cool-season turfgrass species.展开更多
Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increas...Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increases resistance but also has adverse effects on their propulsion performance.On the basis of coupled computational fluid dynamics(CFD)and the discrete element method(DEM),this paper aims to numerically investigate the resistance and propulsion performance of a polar in a brash ice channel while considering the rotation status of the propeller by both experimental and numerical methods.Both ship resistance and ice motion under Froude numbers of 0.0557,0.0696,0.0836,0.975,and 0.1114 are studied when the propeller does not rotate.The influences of the rotating propeller on the ice brash resistance and flow are discussed.The thrust due to the propeller and ice resistance in the equilibrium state are also predicted.The errors between the thrust and total resistance are approximately 1.0%,and the maximum error between the simulated and predicted total resistance is 3.7%,which validates the CFD-DEM coupling method quite well.This work could provide a theoretical basis for the initial design of polar ships with low ice class notation and assist in planning navigation for merchant polar ships in brash ice fields.展开更多
In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The ...In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).展开更多
Ultrathin 2D niobium oxide dichloride(NbOCl2)is an emerging member of the 2D ferroelectric material family with extensive potential to provide multifunctionality in electronic devices and nanophotonics elements.It ...Ultrathin 2D niobium oxide dichloride(NbOCl2)is an emerging member of the 2D ferroelectric material family with extensive potential to provide multifunctionality in electronic devices and nanophotonics elements.It exhibits negligible interlayer electronic coupling and significant excitonic behavior in the bulk state.Here we substantiate that NbOCl2 nanosheets can be exfoliated and effectively size-selected using controlled centrifugation techniques by the liquid phase exfoliation(LPE)method.Spectroscopic measurements displayed that the variations in dispersion were highly dependent on the nanosheet dimensions.The nanosheets seemed to be comparatively defect-free which will be further corroborated by high resolution transmission electron microscopy(HRTEM)and Raman analysis.The size selected nanosheets are unanticipated stable in isopropyl alcohol(IPA),possibly owing to the protective influence of a solvation shell.Additionally,the photothermal conversion response and photothermal stability of nanosized NbOCl2 were investigated.Our finding revealed that NbOCl2 possesses a robust photothermal agent property,boasting a photothermal conversion efficiency of more than 30%.This underscores its promising potential for various photothermal applications in different fields such as photothermal therapy and thermal energy conversion.展开更多
Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing t...Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing technology faces significant challenges in efficiently producing highly uniform microstructures with characteristic dimensions of∼1μm across hundreds of millimeters.Here,we report a laser optical field modulation(LOFM)technology for the rapid manufacture of ultra-large-scale arrays of antireflection microholes(ARMHs)on large-aperture and non-perfectly planar windows.LOFM technology,which modulates laser pulses in both temporal and spatial domains,enhances ARMH aspect ratios from 0.1 to 0.8 without reducing manufacturing time,and maintains processing accuracy even with laser focus shifts,thereby addressing inconsistencies in large-area processing.As a proof of concept,approximately 7 billion ARMHs are fabricated on a 100-mm-diameter zinc sulfide(ZnS)window at a rate of 20000 holes per second using LOFM technology assisted by machine learning.The fabricated DBAR ZnS window exhibits ultra-broadband(3.5−14μm),high transmittance(91.1%),wide-angle transmission,wear-resistant,and self-cleaning,making it suitable for environments with multiple interference factors.Dual-band imaging applications demonstrate the significant advantages of DBAR windows in target recognition,multi-scenario robustness,and information acquisition.展开更多
Structure-ice interaction problems have attracted increasing attention,yet accurately predicting the loads exerted by sea ice on ship hulls remains a significant challenge.Over the past few decades,various numerical m...Structure-ice interaction problems have attracted increasing attention,yet accurately predicting the loads exerted by sea ice on ship hulls remains a significant challenge.Over the past few decades,various numerical methods have been employed to simulate ice resistance on ships and evaluate their manoeuvrability during ice-structure interaction.Among these approaches,the circumferential crack method has demonstrated both high efficiency and accuracy.This paper provides a detailed introduction to the fundamental theory of this method,including the numerical modeling of different failure modes and the dynamic ice motion responses.Furthermore,it reviews existing studies on predicting ice resistance and assessing the manoeuvrability of icebreakers navigating through ice-covered regions using the circumferential crack method.Several recommendations for future research in this field are also presented.展开更多
The pH clock is critical for identifying acid-sensitive substances and elucidating the mechanisms of chemical processes using spectral techniques.Effectively controlling the rate of H+release with inorganic acids is c...The pH clock is critical for identifying acid-sensitive substances and elucidating the mechanisms of chemical processes using spectral techniques.Effectively controlling the rate of H+release with inorganic acids is challenging due to their fast acidification property.In addition,the strong corrosiveness of inorganic acids and the slowing rate of acidification in organic acids with decreasing pH further limit their applicability in fine spectral analysis.Therefore,developing a simple,safe,acidifying agent capable of controlling H+release with a well-defined identification window is crucial for advancing spectral detection technologies.This study presents niobium oxide dichloride(NbOCl2)nanosheets as a novel acidifying agent that not only regulates the rate of H+release but also has a smooth extinction spectrum,making it suitable for monitoring acid-responsive behavior.The results demonstrate that NbOCl2is an excellent platform for pH clocks.Using spectral dynamics and first derivative images of the time-resolved extinction data,we have quantified the key factors associated with the wavelength of the extinction spectrum.Transient absorption results further indicated that H+released from NbOCl2nanosheets reduced absorption,with its carrier dynamics exhibiting pronounced size dependence.These properties suggest NbOCl2nanosheets to be an ideal candidate as an acidifying agent.展开更多
A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was syst...A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)2Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles.展开更多
The machine learning method was employed to accelerate alloy design,and experimental feedback was provided to enhance predictive accuracy.A Cu-2.7Ni-1.0Co-0.8Si alloy with superior properties was selected using a doub...The machine learning method was employed to accelerate alloy design,and experimental feedback was provided to enhance predictive accuracy.A Cu-2.7Ni-1.0Co-0.8Si alloy with superior properties was selected using a double-objective optimization algorithm.The microstructure and properties of the designed alloy subjected to thermomechanical treatment were investigated systematically.The role of the key alloying element Co was discussed via first-principles calculations.The results showed that the designed alloy exhibited favorable comprehensive properties,with a microhardness of 283 HV,a tensile strength of1006 MPa,and an electrical conductivity of 41.3%IACS.The strength was mainly attributed to the combined effects of dislocation strengthening and precipitation strengthening,whereas the electrical conductivity was primarily limited by the solubility of solute atoms.The addition of an appropriate content of Co accelerated precipitation and increased the volume fraction of the precipitates,thereby synergistically enhancing the mechanical properties and electrical conductivity.This was attributed to the effect of Co on increasing the vacancy binding energy and decreasing the formation enthalpy of the precipitates.展开更多
This study utilized a comparative methodology to explore the generative design of museum floor plans,addressing the complexity of meeting curatorial,designer,and visitor de-mands.A dataset of 263 museum plans was cura...This study utilized a comparative methodology to explore the generative design of museum floor plans,addressing the complexity of meeting curatorial,designer,and visitor de-mands.A dataset of 263 museum plans was curated,and four generative methods―LoRA for diffusion models,Pix2Pix,CycleGAN,and the generative segmentation model―were trained.The results were evaluated by FID,SSIM,and MAE metrics for image fidelity and diversity.The pixel-based space syntax method was applied to evaluate the connectivity of the functional space,and expert scoring was combined to assess whether the generated plans met the layout characteristics of museums.Findings are:First,Pix2Pix led in terms of the image structural similarity metric SSIM and diversity metric FID but scored lowest in the image detail recon-struction metric MAE.Second,space syntax analysis revealed that the generated layouts had greater exhibition space connectivity but lower public space connectivity than the original images.Third,the expert grading results indicate that the outputs of LoRA better align with the professional expectations of designers regarding functional composition and spatial orga-nization.These findings highlight the potential of generative models in museum design,partic-ularly when enhanced by space syntax evaluations to improve spatial intelligibility and meet diverse stakeholder needs.展开更多
The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept o...The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept of characteristic databases alliance,using marine characteristic databases as a case for feasibility analysis and discussion.The paper outlines the development path for such alliances and offers recommendations for future growth,aiming to establish a collaborative platform for the development of characteristic databases.展开更多
Remote sensing data from the Terra Moderate-Resolution Imaging Spectroradiometer (MODIS) and geospatial data were used to estimate grass yield and livestock carrying capacity in the Tibetan Autonomous Prefecture of Go...Remote sensing data from the Terra Moderate-Resolution Imaging Spectroradiometer (MODIS) and geospatial data were used to estimate grass yield and livestock carrying capacity in the Tibetan Autonomous Prefecture of Golog, Qing-hai, China. The MODIS-derived normalized difference vegetation index (MODIS-NDVI) data were correlated with the aboveground green biomass (AGGB) data from the aboveground harvest method. Regional regression model between the MODIS-NDVI and the common logarithm (LOG10) of the AGGB was significant (r2 = 0.51, P < 0.001), it was, there-fore, used to calculate the maximum carrying capacity in sheep-unit year per hectare. The maximum livestock carrying capacity was then adjusted to the theoretical livestock carrying capacity by the reduction factors (slope, distance to water, and soil erosion). Results indicated that the grassland conditions became worse, with lower aboveground palatable grass yield, plant height, and cover compared with the results obtained in 1981. At the same time, although the actual livestock numbers decreased, they still exceeded the proper theoretical livestock carrying capacity, and overgrazing rates ranged from 27.27% in Darlag County to 293.99% in Baima County. Integrating remote sensing and geographical information system technologies, the spatial and temporal conditions of the alpine grassland, trend, and projected stocking rates could be forecasted for decision making.展开更多
A study is conducted on a new airworthiness compliance verification method based on pilot-aircraft-environment complex system simulation. Verification scenarios are established by "block diagram" method based on air...A study is conducted on a new airworthiness compliance verification method based on pilot-aircraft-environment complex system simulation. Verification scenarios are established by "block diagram" method based on airworthiness criteria. A pi- lot-aircraft-environment complex model is set up and a virtual flight testing method based on connection of MATLAB/Simulink and Flightgear is proposed. Special researches are conducted on the modeling of pilot manipulation stochastic parameters and manipulation in critical situation. Unfavorable flight factors of certain scenario are analyzed, and reliability modeling of impor- tant system is researched. A distribution function of small probability event and the theory on risk probability measurement are studied. Nonlinear function is used to depict the relationship between the cumulative probability and the extremum of the critical parameter. A synthetic evaluation model is set up, modified genetic algorithm (MGA) is applied to ascertaining the distribution parameter in the model, and a more reasonable result is obtained. A clause about vehicle control functions (VCFs) verification in MIL-HDBK-516B is selected as an example to validate the practicability of the method.展开更多
OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-co...OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable.展开更多
基金supported by the Basic Research Special Foundation of Public Research Institutes of Fujian Province(2022R1030001,2022R1030002,2023R1028004 and 2025R1028004)the Natural Science Foundation of Fujian Province(2023J01373 and 2025J01425)Natural Science Foundation of Zhangzhou(ZZ2024J24).
摘要Pepper(Capsicum annuum L.)is highly susceptible to chilling stress,which severely constrains its growth and productivity.Although the eco-friendly biostimulantγ-polyglutamic acid(γ-PGA)has shown promise in enhancing plant tolerance to abiotic stresses,its specific role and underlying mechanisms in alleviating chilling injury in pepper remain poorly understood.This study systematically investigated the physiological and molecular mechanisms by which foliar application of 100 mg⋅L-1γ-PGA enhances chilling tolerance in pepper seedlings.Our results demonstrated thatγ-PGA pretreatment significantly mitigated chilling-induced growth inhibition and promoted root development,evidenced by a 110.8%increase in the number of root tips.Analysis of photosynthetic performance revealed thatγ-PGA effectively counteracted chilling-induced photosynthetic suppression,increasing the net photosynthetic rate(Pn)by 172.9%and the maximum photochemical efficiency of PSII(Fv/Fm)by 17.9%.Furthermore,γ-PGA treatment significantly reduced the accumulation of reactive oxygen species(O2·-and H2O2)and malondialdehyde(MDA)while promoting the synthesis of the osmoprotectant proline.This protective effect was associated with a strengthened antioxidant defense system;γ-PGA enhanced the activities of superoxide dismutase(SOD),catalase(CAT),and ascorbate peroxidase(APX).These changes were supported at the molecular level by the significant upregulation of their corresponding genes(CaSOD,CaCAT,and CaAPX),with CaAPX expression showing a striking 313.5%increase.In conclusion,foliar application ofγ-PGA enhances chilling tolerance in pepper seedlings via a multi-faceted mechanism that includes improving root architecture,reinforcing the antioxidant defense system,facilitating osmotic adjustment,and protecting the photosynthetic apparatus.These findings provide a theoretical framework and practical support for usingγ-PGA as an effective and sustainable biostimulant to improve pepper cultivation in environments prone to chilling stress.
基金supported by the National Natural Science Foundation of China(51672312&52262042)joint supported by Hubei Provincial Natural Science Foundation and Huangshi of China(2022CFD001)+2 种基金the Fundamental Research Funds for the Central Universities of South-Central Minzu University(CZZ25013)the Fund for Academic Innovation Teams of South-Central Minzu University of China(XTZ24019)SACC acknowledges FCT/MCTES(Fundação para a Ciência e Tecnologia and Ministério da Ciência,Tecnologia e Ensino Superior of Portugal)for UID/50006/2023 and DOI 10.54499/CEECINST/00102/2018/CP1567/CT0026).
摘要The polymeric semiconductor photocatalyst graphitic carbon nitride(g-C3N4)has attracted considerable attention due to its visible-light responsiveness and excellent biocompatibility.However,the photocatalytic efficiency of bulk g-C3N4(CNB)remains insufficient for pratical applications,primarily due to its limited light absorption range and the rapid charge carrier recombination.In this study,K+-doped crystalline g-C3N4with cyano defects(CNK)was synthesized by the calcination of dicyandiamide in the presence of KCl.The addition of KCl promoted the formation of K+-doped crystalline g-C3N4with cyano defects.The optimized photocatalyst(CNK2)exhibits the highest photocatalytic activity for NO oxidation,achieving a removal rate of 47.40%,which is 2.1 times higher than that of CNB.This enhancement is mainly attributed to the increased generation of reactive oxygen species(ROS),particularly superoxide radicals(·O2-)and singlet oxygen(1O2).Furthermore,improved performance in photocatalytic CO2-to-CH4 conversion was also observed,which is attributed to the formation of a build-in electric field(BIEF)induced by K+ion doping and the introduction of cyano defects.
基金supports from National Key R&D Program of China(Grant No.2023YFB4605500)National Natural Science Foundation of China(Grant No.52105498)+3 种基金Natural Science Foundation of Hunan Province(Grant No.2022JJ40597)the Science and Technology Innovation Program of Hunan Province(Grant No.2022RC1132)State Key Laboratory of Precision Manufacturing for Extreme Service Performance(Grant No.ZZYJKT2023-08)support in analyzing the status of ultrafast laser welding applications,as well as the corresponding project support(Grant No.HKF202400595).
摘要The ultrafast laser-matter interaction is explored to induce new pioneering principles and technologies into the realms of fundamental science and industrial production.The local thermal melting and connection properties of the ultrafast laser welding technology offer a novel method for welding of diverse transparent materials,thus having wide range of potential applications in aerospace,opto-mechanical systems,sensors,microfluidic,optics,etc.In this comprehensive review,tuning the transient electron activation processes,high-rate laser energy deposition,and dynamic evolution of plasma morphology by the temporal/spatial shaping methods have been demonstrated to facilitate the transition from conventional homogeneous transparent material welding to the more intricate realm of transparent/metal heterogeneous material welding.The welding strength and stability are also improvable through the implementation of real-time,in-situ monitoring techniques and the prompt diagnosis of welding defects.The principles of ultrafast laser welding,bottleneck problems in the welding,novel welding methods,advances in welding performance,in-situ monitoring and diagnosis,and various applications are reviewed.Finally,we offer a forward-looking perspective on the fundamental challenges within the field of ultrafast laser welding and identify key areas for future research,underscoring the imperative need for ongoing innovation and exploration.
基金supported by the National Natural Science Foundation of China (U22A20277,81971373)Jiangsu Provincial Medical Key Discipline Cultivation Unit (JSDW202215)+1 种基金333 High-level Personnel Training Project of Jiangsu Province (BRA2019109)Postgraduate Research&Practice Innovation Program of Jiangsu Province (KYCX22_1826)。
摘要Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in nonobstructive azoospermia(NOA),a severe form of male infertility.However,the precise mechanisms linking fatty acid metabolism to NOA pathogenesis have not yet been fully elucidated.Multi-omics analyses,including microarray analysis,single-cell RNA sequencing(scRNA-seq),and metabolomics,were utilized to investigate disruptions in fatty acid metabolism associated with NOA using data from public databases.Results identified ACSL6,ACSBG2,and OLAH as key genes linked to fatty acid metabolism dysregulation,suggesting their potential causative roles in NOA.A marked reduction in omega-3 polyunsaturated fatty acids,especially docosahexaenoic acid(DHA),was observed,potentially contributing to the pathological process of NOA.Sertoli cells in NOA patients exhibited apparent fatty acid metabolic dysfunction,with PPARG identified as a key transcription factor(TF)regulating this process.Functional analyses demonstrated that PPARG is crucial for maintaining blood-testis barrier(BTB)integrity and promoting spermatogenesis via regulation of fatty acid metabolism.These findings reveal the pivotal role of fatty acid metabolism in NOA and identify PPARG as a potential therapeutic target.
基金financially supported by Sichuan Science and Technology Program(Grant No.2023NSFSC1980).
摘要This study examines the adaptive boundary control problem of flexible marine riser with internal flow coupling.The dynamic model of the flexible marine riser system with internal flow coupling is derived using the Hamiltonian principle.An analysis of internal flow’s influence on the vibration characteristics of flexible marine risers is conducted.Then,for the uncertain environmental disturbance,the adaptive fuzzy logic system is introduced to dynamically approximate the boundary disturbance,and a robust adaptive fuzzy boundary control is proposed.The uniform boundedness of the closed-loop system is proved based on Lyapunov theory.The well-posedness of the closed-loop system is proved by operator semigroup theory.The proposed control’s effectiveness is validated through comparison with existing control methods.
基金supported by the Sichuan Students'Innovation Training Program(S202410626051).
摘要Diethyl aminoethyl hexanoate(DA-6)is involved in the regulation of adaptive response of plants to unfavorable environmental conditions.The objective ofthis experiment was to examine whether the DA-6 pretreatment could effectively alleviate drought-triggered leaf senescence and oxidative injury tocreeping bentgrass.Plants were exogenously irrigated with or without DA-6(0.4 mM·L-1)before being subjected to PEG-induced drought stress for 9 d.Drought stress resulted in significant growth retardation,Chl loss,and decreases in leaf relative water content,water use efficiency,photochemicalefficiency,and net photosynthetic rate,but significantly enhanced oxidative damage.Exogenous DA-6 markedly alleviated symptoms of drought stress byimproving water homeostasis,ROS scavenging,Chl biosynthesis,and photosynthesis.In contrast to untreated plants,the DA-6-pretreated creepingbentgrass demonstrated significantly higher transcript levels of genes related to rubisco activity(AsRuBisCo),and Chl biosynthesis(AsMg-CHT,AsPBGD,AsPOR,and AsCHLH),but lower transcript levels of Chl degradation-related genes(AsPAO,AsCLH,and AsPPH),and senescence-associated genes(Asl20 andAsh36),thereby decreasing leaf senescence and ameliorating photosynthetic performance under drought stress.Moreover,DA-6 also significantlypromoted activities of superoxide dismutase,peroxidase,catalase,and ascorbate peroxidase,hence efficiently diminishing drought-stimulated oxidativedamage.The current study supplies important information about DA-6-regulated growth and drought tolerance associated with osmotic adjustment,antioxidant defense,photosynthetic function,and Chl metabolism in cool-season turfgrass species.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFE0107000)the Fundamental Research Funds for the Central Universities(Grant No.HYGJXM202319).
摘要Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increases resistance but also has adverse effects on their propulsion performance.On the basis of coupled computational fluid dynamics(CFD)and the discrete element method(DEM),this paper aims to numerically investigate the resistance and propulsion performance of a polar in a brash ice channel while considering the rotation status of the propeller by both experimental and numerical methods.Both ship resistance and ice motion under Froude numbers of 0.0557,0.0696,0.0836,0.975,and 0.1114 are studied when the propeller does not rotate.The influences of the rotating propeller on the ice brash resistance and flow are discussed.The thrust due to the propeller and ice resistance in the equilibrium state are also predicted.The errors between the thrust and total resistance are approximately 1.0%,and the maximum error between the simulated and predicted total resistance is 3.7%,which validates the CFD-DEM coupling method quite well.This work could provide a theoretical basis for the initial design of polar ships with low ice class notation and assist in planning navigation for merchant polar ships in brash ice fields.
基金support of the Research Project Supported by Shanxi Scholarship Council of China(2022-040)"Chunhui Plan"Collaborative Research Project by the Ministry of Education of China(HZKY20220507)+2 种基金National Natural Science Foundation of China(52104338)Applied Fundamental Research Programs of Shanxi Province(202303021221036)Shandong Postdoctoral Science Foundation(SDCX-ZG-202303027,SDBX2023054).
摘要In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).
基金Projects(62275275,11904239)supported by the National Natural Science Foundation of ChinaProjects(2021JJ40709,2022JJ20080)supported by the Natural Science Foundation of Hunan Province,China。
摘要Ultrathin 2D niobium oxide dichloride(NbOCl2)is an emerging member of the 2D ferroelectric material family with extensive potential to provide multifunctionality in electronic devices and nanophotonics elements.It exhibits negligible interlayer electronic coupling and significant excitonic behavior in the bulk state.Here we substantiate that NbOCl2 nanosheets can be exfoliated and effectively size-selected using controlled centrifugation techniques by the liquid phase exfoliation(LPE)method.Spectroscopic measurements displayed that the variations in dispersion were highly dependent on the nanosheet dimensions.The nanosheets seemed to be comparatively defect-free which will be further corroborated by high resolution transmission electron microscopy(HRTEM)and Raman analysis.The size selected nanosheets are unanticipated stable in isopropyl alcohol(IPA),possibly owing to the protective influence of a solvation shell.Additionally,the photothermal conversion response and photothermal stability of nanosized NbOCl2 were investigated.Our finding revealed that NbOCl2 possesses a robust photothermal agent property,boasting a photothermal conversion efficiency of more than 30%.This underscores its promising potential for various photothermal applications in different fields such as photothermal therapy and thermal energy conversion.
基金supported by the National Key R&D Program of China(Grant No.2023YFB4605500)Excellent Young Scientists Program of Hunan Provincial Department of Education(Grant No.23B0017)+2 种基金National Natural Science Foundation of China(Grant No.52105498)Natural Science Foundation of Hunan Province(Grant No.2023JJ40736)National Postdoctoral Program for Innovative Talents(BX20220353).
摘要Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing technology faces significant challenges in efficiently producing highly uniform microstructures with characteristic dimensions of∼1μm across hundreds of millimeters.Here,we report a laser optical field modulation(LOFM)technology for the rapid manufacture of ultra-large-scale arrays of antireflection microholes(ARMHs)on large-aperture and non-perfectly planar windows.LOFM technology,which modulates laser pulses in both temporal and spatial domains,enhances ARMH aspect ratios from 0.1 to 0.8 without reducing manufacturing time,and maintains processing accuracy even with laser focus shifts,thereby addressing inconsistencies in large-area processing.As a proof of concept,approximately 7 billion ARMHs are fabricated on a 100-mm-diameter zinc sulfide(ZnS)window at a rate of 20000 holes per second using LOFM technology assisted by machine learning.The fabricated DBAR ZnS window exhibits ultra-broadband(3.5−14μm),high transmittance(91.1%),wide-angle transmission,wear-resistant,and self-cleaning,making it suitable for environments with multiple interference factors.Dual-band imaging applications demonstrate the significant advantages of DBAR windows in target recognition,multi-scenario robustness,and information acquisition.
基金financially supported by the National Natural Science Foundation of China(Grant No.52171259)the National Key Technologies Research and Development Program(Grant No.2022YFE0107000)+1 种基金the High-tech Ship Research Project of the Ministry of Industry and Information Technology(Grant No.[2021]342)the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.52301331).
摘要Structure-ice interaction problems have attracted increasing attention,yet accurately predicting the loads exerted by sea ice on ship hulls remains a significant challenge.Over the past few decades,various numerical methods have been employed to simulate ice resistance on ships and evaluate their manoeuvrability during ice-structure interaction.Among these approaches,the circumferential crack method has demonstrated both high efficiency and accuracy.This paper provides a detailed introduction to the fundamental theory of this method,including the numerical modeling of different failure modes and the dynamic ice motion responses.Furthermore,it reviews existing studies on predicting ice resistance and assessing the manoeuvrability of icebreakers navigating through ice-covered regions using the circumferential crack method.Several recommendations for future research in this field are also presented.
基金Projects(52227806,62275275)supported by the National Natural Science Foundation of ChinaProject(2023YFC3906103)supported by the National Key R&D Program of ChinaProjects(2021JJ40709,2022JJ20080,2024JJ6481)supported by the Natural Science Foundation of Hunan Province,China。
摘要The pH clock is critical for identifying acid-sensitive substances and elucidating the mechanisms of chemical processes using spectral techniques.Effectively controlling the rate of H+release with inorganic acids is challenging due to their fast acidification property.In addition,the strong corrosiveness of inorganic acids and the slowing rate of acidification in organic acids with decreasing pH further limit their applicability in fine spectral analysis.Therefore,developing a simple,safe,acidifying agent capable of controlling H+release with a well-defined identification window is crucial for advancing spectral detection technologies.This study presents niobium oxide dichloride(NbOCl2)nanosheets as a novel acidifying agent that not only regulates the rate of H+release but also has a smooth extinction spectrum,making it suitable for monitoring acid-responsive behavior.The results demonstrate that NbOCl2is an excellent platform for pH clocks.Using spectral dynamics and first derivative images of the time-resolved extinction data,we have quantified the key factors associated with the wavelength of the extinction spectrum.Transient absorption results further indicated that H+released from NbOCl2nanosheets reduced absorption,with its carrier dynamics exhibiting pronounced size dependence.These properties suggest NbOCl2nanosheets to be an ideal candidate as an acidifying agent.
基金the financial support by the National Natural Science Foundation of China(No.U2202255)the Hunan Provincial Natural Science Foundation of China(No.2024JJ2076)the Key Research and Development Program of Ningbo,China(No.2023Z092)。
摘要A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)2Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles.
基金financially supported by the Key Technology Research Program of Ningbo,China(Grant No.2023Z092)the National Natural Science Foundation of China(Grant No.U2202255)+1 种基金Hunan Provincial Natural Science Foundation of China(Grant No.2024JJ2076)Henan Province Science and Technology R&D Program(Grant No.235200810004)。
摘要The machine learning method was employed to accelerate alloy design,and experimental feedback was provided to enhance predictive accuracy.A Cu-2.7Ni-1.0Co-0.8Si alloy with superior properties was selected using a double-objective optimization algorithm.The microstructure and properties of the designed alloy subjected to thermomechanical treatment were investigated systematically.The role of the key alloying element Co was discussed via first-principles calculations.The results showed that the designed alloy exhibited favorable comprehensive properties,with a microhardness of 283 HV,a tensile strength of1006 MPa,and an electrical conductivity of 41.3%IACS.The strength was mainly attributed to the combined effects of dislocation strengthening and precipitation strengthening,whereas the electrical conductivity was primarily limited by the solubility of solute atoms.The addition of an appropriate content of Co accelerated precipitation and increased the volume fraction of the precipitates,thereby synergistically enhancing the mechanical properties and electrical conductivity.This was attributed to the effect of Co on increasing the vacancy binding energy and decreasing the formation enthalpy of the precipitates.
基金funded by the National Social Science Found of China(Grant No.24BG121).
摘要This study utilized a comparative methodology to explore the generative design of museum floor plans,addressing the complexity of meeting curatorial,designer,and visitor de-mands.A dataset of 263 museum plans was curated,and four generative methods―LoRA for diffusion models,Pix2Pix,CycleGAN,and the generative segmentation model―were trained.The results were evaluated by FID,SSIM,and MAE metrics for image fidelity and diversity.The pixel-based space syntax method was applied to evaluate the connectivity of the functional space,and expert scoring was combined to assess whether the generated plans met the layout characteristics of museums.Findings are:First,Pix2Pix led in terms of the image structural similarity metric SSIM and diversity metric FID but scored lowest in the image detail recon-struction metric MAE.Second,space syntax analysis revealed that the generated layouts had greater exhibition space connectivity but lower public space connectivity than the original images.Third,the expert grading results indicate that the outputs of LoRA better align with the professional expectations of designers regarding functional composition and spatial orga-nization.These findings highlight the potential of generative models in museum design,partic-ularly when enhanced by space syntax evaluations to improve spatial intelligibility and meet diverse stakeholder needs.
摘要The characteristic databases in China face issues such as narrow resource coverage,low levels of standardization and normalization,and limited data sharing.To address these challenges,this paper proposes the concept of characteristic databases alliance,using marine characteristic databases as a case for feasibility analysis and discussion.The paper outlines the development path for such alliances and offers recommendations for future growth,aiming to establish a collaborative platform for the development of characteristic databases.
基金Supported by the National Basic Research Program (973 Program) of China (Nos.2009CB421102 and 2005CB422005-01)the Second Scheme of CAS Action Plan for the Development of Western China (No.KZCX2-XB2-06-02)the National Key Technology R&D Program of China (No.2006BAC01A02-01)
摘要Remote sensing data from the Terra Moderate-Resolution Imaging Spectroradiometer (MODIS) and geospatial data were used to estimate grass yield and livestock carrying capacity in the Tibetan Autonomous Prefecture of Golog, Qing-hai, China. The MODIS-derived normalized difference vegetation index (MODIS-NDVI) data were correlated with the aboveground green biomass (AGGB) data from the aboveground harvest method. Regional regression model between the MODIS-NDVI and the common logarithm (LOG10) of the AGGB was significant (r2 = 0.51, P < 0.001), it was, there-fore, used to calculate the maximum carrying capacity in sheep-unit year per hectare. The maximum livestock carrying capacity was then adjusted to the theoretical livestock carrying capacity by the reduction factors (slope, distance to water, and soil erosion). Results indicated that the grassland conditions became worse, with lower aboveground palatable grass yield, plant height, and cover compared with the results obtained in 1981. At the same time, although the actual livestock numbers decreased, they still exceeded the proper theoretical livestock carrying capacity, and overgrazing rates ranged from 27.27% in Darlag County to 293.99% in Baima County. Integrating remote sensing and geographical information system technologies, the spatial and temporal conditions of the alpine grassland, trend, and projected stocking rates could be forecasted for decision making.
基金National Natural Science Foundation of China (60572172, 61074007)
摘要A study is conducted on a new airworthiness compliance verification method based on pilot-aircraft-environment complex system simulation. Verification scenarios are established by "block diagram" method based on airworthiness criteria. A pi- lot-aircraft-environment complex model is set up and a virtual flight testing method based on connection of MATLAB/Simulink and Flightgear is proposed. Special researches are conducted on the modeling of pilot manipulation stochastic parameters and manipulation in critical situation. Unfavorable flight factors of certain scenario are analyzed, and reliability modeling of impor- tant system is researched. A distribution function of small probability event and the theory on risk probability measurement are studied. Nonlinear function is used to depict the relationship between the cumulative probability and the extremum of the critical parameter. A synthetic evaluation model is set up, modified genetic algorithm (MGA) is applied to ascertaining the distribution parameter in the model, and a more reasonable result is obtained. A clause about vehicle control functions (VCFs) verification in MIL-HDBK-516B is selected as an example to validate the practicability of the method.
基金Supported by National Major Scientific and Technological Special Project for"Significant New Drugs development"(No.2017ZX09304019)National Major Scientific and Technological Special Project for Clinical Evaluation Technology Platform of"Disease,Symptom Pattern and Symptom Correlation"of New Traditional Chinese Medicine。
摘要OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable.