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LAG3 facilitates MHC Ⅱ trogocytosis with assistance of the ERPM junction 认领 引用
1
作者 Zibin Wang Jing Wang +1 位作者 Wene Zhao Wen Liu 《Journal of Biomedical Research》 CAS CSCD 2026年第1期89-92,共4页
Dear Editor,Lymphocyte activation gene 3(LAG3),the third established target for immune checkpoint blockade therapy,suppresses T cell function by binding to major histocompatibility complex classⅡ(MHCⅡ).Despite its s... Dear Editor,Lymphocyte activation gene 3(LAG3),the third established target for immune checkpoint blockade therapy,suppresses T cell function by binding to major histocompatibility complex classⅡ(MHCⅡ).Despite its significant therapeutic potential in cancer immunotherapy and the substantial attention it has received from academia and industry,the molecular mechanisms of LAG3-mediated immunosuppression remain poorly understood,primarily because of its unique ligand-binding characteristics and intracellular domains[1]. 展开更多
关键词 Lag Immunosuppression cancer immunotherapy immune checkpoint blockade therapysuppresses t cell function ERPM Trogocytosis MHC
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Joint Trajectory and Power Optimization for Securing UAV Communications Against Active Eavesdropping 认领 引用 被引量：9
2
作者 Bin Duo Junsong Luo +2 位作者 Yilian Li Hao Hu Zibin Wang 《China Communications》 SCIE EI CSCD 2021年第1期88-99,共12页
Due to both of jamming and eavesdropping,active eavesdroppers can induce more serious security threats to unmanned aerial vehicle(UAV)-enabled communications.This paper considers a secure UAV communication system incl... Due to both of jamming and eavesdropping,active eavesdroppers can induce more serious security threats to unmanned aerial vehicle(UAV)-enabled communications.This paper considers a secure UAV communication system including both the downlink(DL)and uplink(UL)transmissions,where the confidential information is transmitted between a UAV and a ground node in the presence of an active eavesdropper.We aim to maximize the average secrecy rates of the DL and UL communications,respectively,by jointly optimizing the UAV trajectory and the UAV/ground node’s transmit power control over a given flight period.Due to the non-convexity of the formulated problems,it is difficult to obtain globally optimal solutions.However,we propose efficient iterative algorithms to obtain high-quality suboptimal solutions by applying the block coordinate descent and successive convex optimization methods.Simulation results show that the joint optimization algorithms can effectively improve the secrecy rate performance for both the DL and UL communications,as compared with other baseline schemes.The proposed schemes can be considered as special cases of UAV-assisted non-orthogonal multiple access(NOMA)networks. 展开更多
关键词 UAV communications active eavesdropping physical-layer security secrecy rate maximization power control trajectory design
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RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila 认领 引用
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作者 Ya Wang Rui Xu +11 位作者 Yiwei Cheng Haowei Cao Zibin Wang Tianyu Zhu Jiayin Jiang Hao Zhang Chang Wang Lin Qi Mingxi Liu Xuejiang Guo Juan Huang Jiahao Sha 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2019年第6期281-290,共10页
Flagellum in sperm is composed of over 200 different proteins and is essential for sperm motility. In particular, defects in the assembly of the radial spoke in the flagellum result in male infertility due to loss of ... Flagellum in sperm is composed of over 200 different proteins and is essential for sperm motility. In particular, defects in the assembly of the radial spoke in the flagellum result in male infertility due to loss of sperm motility. However, mechanisms regulating radial spoke assembly remain unclear in metazoans.Here, we identified a novel Drosophila protein radial spoke binding protein 15(RSBP15) which plays an important role in regulating radial spoke assembly. Loss of RSBP15 results in complete lack of mature sperms in seminal vesicles(SVs), asynchronous individualization complex(IC) and defective "9 + 2"structure in flagella. RSBP15 is colocalized with dRSPH3 in sperm flagella, and interacts with dRSPH3 through its DD_R_PKA superfamily domain which is important for the stabilization of dRSPH3. Moreover,loss of dRSPH3, as well as dRSPH1, dRSPH4 a and dRSPH9, showed similar phenotypes to rsbp15 KO mutant. Together, our results suggest that RSBP15 acts in stabilizing the radial spoke protein complex to anchor and strengthen the radial spoke structures in sperm flagella. 展开更多
关键词 RSBP15 RSPH3 Flagellum Radial spoke Drosophila
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