期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到1篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Developing HMME-Conjugated NIR-ⅡActivated Carbon Dots Nanospray for the Treatment of MRSA Biofilm Infections in Diabetic Wound via PTT/CDT/SDT 认领 引用
1
作者 Liang Zhou Ning Wang +6 位作者 Zumeng Wang Pingping Zhang Yuqin Chu Yingguang Liu Wen Liu Chengwu Zhang Lili Yan 《Rare Metals》 SCIE EI CAS CSCD 2026年第4期405-420,共16页
Diabetic wound infections are a common complication of diabetes,which severely impact patients'quality of life.Effective treatment of diabetic wound infections remains one major challenge in the clinic,partially d... Diabetic wound infections are a common complication of diabetes,which severely impact patients'quality of life.Effective treatment of diabetic wound infections remains one major challenge in the clinic,partially due to the formation of bacterial biofilm and antibiotic resistance.It is imperative to develop non-antibiotic-dependent strategies to efficiently eradicate biofilm infections in diabetic wounds.In this work,an innovative nanospray(CDs-HM)was successfully prepared by linking one acoustic sensitizer(hematoporphyrin monomethyl ether,HMME)to CDs fabricated with hemin,nickel(Ⅱ)chloride,and polymer ethylene imine.CDs-HM exhibited catalase-enhanced sonodynamic properties and photothermal-enhanced chemodynamic properties.In vitro experiments and transcriptomic analysis demonstrated that CDs-HM successfully killed the bacteria and destroyed bacterial biofilm by disrupting bacterial cell membrane integrity,inducing oxidative stress,and inhibiting ATP production through synergistic photothermal therapy/chemodynamic therapy/sonodynamic therapy(PTT/CDT/SDT)effects.In the diabetic wound infection mouse model,CDs-HM remarkably eradicated MRSA biofilm,reduced inflammation levels,and promoted angiogenesis/collagen deposition so as to accelerate wound healing.It is noteworthy that CDs-HM displayed superior bacteria killing and wound healing effects compared with conventional vancomycin and nanosilver dressing interventions.The practicality and effciency of CDs-HM endowed it with broad clinical translation prospects.It paved the way for developing novel strategies for combating diabetic wound infections. 展开更多
关键词 bacterial biofilm carbon dots diabetic infections hematoporphyrin monomethyl ether synergistic therapy wound healing
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈