The associations of co-exposure to per-and polyfluoroalkyl substances(PFAS),polycyclic aromatic hydrocarbons(PAHs),and metals with children’s glycometabolism and the underlying mechanism of immune inflammation are la...The associations of co-exposure to per-and polyfluoroalkyl substances(PFAS),polycyclic aromatic hydrocarbons(PAHs),and metals with children’s glycometabolism and the underlying mechanism of immune inflammation are largely unclear.We conducted a longitudinal panel study to explore the effects of individual and mixture of 27 contaminants on an emerging surrogate indicator of insulin resistance,triglyceride-glucose index(TyG),and the mediation of immunoglobulins and cytokines in children aged 4–6 years and 11–13 years.The results showed robust associations of perfluorooctanoic acid(PFOA),perfluorononanoic acid(PFNA),perfluoroundecanoic acid(PFUnDA),and arsenic(As)with elevated TyG.The interaction of PFNA with PFOA was significant,showing a synergistic effect on TyG.And combined association of each pair of PFOA,PFNA,and As with TyG were enhanced.Meanwhile,the effect of contaminants mixture on TyG was significant for polyfluoroalkyl substances(PFAS)mixture,of which 6:2 Chlorinated polyfluorinated ether sulfonates(Cl-PFESA),PFNA,and PFUnDA weighted more than others.Notably,contaminants were related to immune globulins and cytokines,of which chemokine ligand(CCL)4,interleukin(IL)-1β,IL-9,and tumor necrosis factor(TNF)-α significantly mediated associations of PFOA,PFNA,and PFUnDA with TyG.Accordingly,PFAS and metals were individually and jointly associated with TyG elevation,with 6:2 Cl-PFESA,PFNA,and PFUnDA contributing the most,and CCL4,IL-1β,IL-9,and TNF-α might be the underlying mediators in children.展开更多
Objective This study aimed to describe 24-hour movement behaviors,including physical activity,sedentary behavior,and sleep period,among Chinese preschoolers using nationally representative data,and examine disparities...Objective This study aimed to describe 24-hour movement behaviors,including physical activity,sedentary behavior,and sleep period,among Chinese preschoolers using nationally representative data,and examine disparities by age,gender,and residence.Methods A cross-sectional analysis was conducted using data from the China National Nutrition and Health Systematic Survey for Children(2019–2021),including 10,935 children aged 3–5 years.Daily total time of physical activity(TPA),total time of sedentary behaviors(TSB),and total sleep period(TSP)was collected via validated structured questionnaires.Physical inactivity was defined as<180 minutes of TPA per day.Results Median TPA was 121.4(IQR:71.4−209.6)minutes/day,and TSB was 231.4(IQR:175.0−304.3)minutes/day,with 11.46±1.00 hours/day average TSP.Overall,68.8%were physically inactive,with higher prevalence in rural(73.3%)versus urban areas(64.8%,P<0.001).TPA and TSB increased with age,while TSP decreased(all P<0.001).No significant gender differences were observed.Conclusion Most Chinese preschoolers exhibit insufficient physical activity and excessive sedentary behaviors,with notable urban–rural disparities and an escalating trend of ageing.Continuous monitoring and targeted interventions,especially in rural areas,are urgently needed.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFC3702702)the National Natural Science Foundation of China(No.82404295)the Fundamental Research Funds for the Central Universities,HUST(No.2020kfyXJJS058).
摘要The associations of co-exposure to per-and polyfluoroalkyl substances(PFAS),polycyclic aromatic hydrocarbons(PAHs),and metals with children’s glycometabolism and the underlying mechanism of immune inflammation are largely unclear.We conducted a longitudinal panel study to explore the effects of individual and mixture of 27 contaminants on an emerging surrogate indicator of insulin resistance,triglyceride-glucose index(TyG),and the mediation of immunoglobulins and cytokines in children aged 4–6 years and 11–13 years.The results showed robust associations of perfluorooctanoic acid(PFOA),perfluorononanoic acid(PFNA),perfluoroundecanoic acid(PFUnDA),and arsenic(As)with elevated TyG.The interaction of PFNA with PFOA was significant,showing a synergistic effect on TyG.And combined association of each pair of PFOA,PFNA,and As with TyG were enhanced.Meanwhile,the effect of contaminants mixture on TyG was significant for polyfluoroalkyl substances(PFAS)mixture,of which 6:2 Chlorinated polyfluorinated ether sulfonates(Cl-PFESA),PFNA,and PFUnDA weighted more than others.Notably,contaminants were related to immune globulins and cytokines,of which chemokine ligand(CCL)4,interleukin(IL)-1β,IL-9,and tumor necrosis factor(TNF)-α significantly mediated associations of PFOA,PFNA,and PFUnDA with TyG.Accordingly,PFAS and metals were individually and jointly associated with TyG elevation,with 6:2 Cl-PFESA,PFNA,and PFUnDA contributing the most,and CCL4,IL-1β,IL-9,and TNF-α might be the underlying mediators in children.
基金supported by National Special Program for Science&Technology Basic Resources Investigation of China(Grant No.2017GFY101100).
摘要Objective This study aimed to describe 24-hour movement behaviors,including physical activity,sedentary behavior,and sleep period,among Chinese preschoolers using nationally representative data,and examine disparities by age,gender,and residence.Methods A cross-sectional analysis was conducted using data from the China National Nutrition and Health Systematic Survey for Children(2019–2021),including 10,935 children aged 3–5 years.Daily total time of physical activity(TPA),total time of sedentary behaviors(TSB),and total sleep period(TSP)was collected via validated structured questionnaires.Physical inactivity was defined as<180 minutes of TPA per day.Results Median TPA was 121.4(IQR:71.4−209.6)minutes/day,and TSB was 231.4(IQR:175.0−304.3)minutes/day,with 11.46±1.00 hours/day average TSP.Overall,68.8%were physically inactive,with higher prevalence in rural(73.3%)versus urban areas(64.8%,P<0.001).TPA and TSB increased with age,while TSP decreased(all P<0.001).No significant gender differences were observed.Conclusion Most Chinese preschoolers exhibit insufficient physical activity and excessive sedentary behaviors,with notable urban–rural disparities and an escalating trend of ageing.Continuous monitoring and targeted interventions,especially in rural areas,are urgently needed.