期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到2,530篇文章
< 1 2 … 127 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention 认领 引用 被引量：1
1
作者 Xue-Mei Wang Ben-Chen Rao +6 位作者 Guan-Yue Su Hai-Yu Wang Gui-Zhen Zhang Fei-Lin Ge Zu-Jiang Yu Zhi-Gang Ren Hong-Xia Liang 《World Journal of Gastroenterology》 SCIE CAS 2026年第16期106-123,共18页
BACKGROUND Aging is the primary risk factor for numerous chronic diseases,cognitive deterioration,and mortality.The gut microbiota is increasingly implicated in the aging process,yet a comprehensive understanding of i... BACKGROUND Aging is the primary risk factor for numerous chronic diseases,cognitive deterioration,and mortality.The gut microbiota is increasingly implicated in the aging process,yet a comprehensive understanding of its dynamic compositional and functional shifts throughout the human lifespan and its mechanistic contributions to aging remains unclear.AIM To study the gut microbiota profiles of age-related changes during aging in both human and rat cohorts,with particular focus on microbiota involved in lipid metabolism.Subsequently,to intervene fatty acid oxidation inhibitor trimetazidine(TMZ)was used in the aging process.METHODS The metagenomic sequencing and 16S rRNA sequencing were performed to detect gut microbiota in 300 individuals of different age groups and rats of different weeks,mapping the evolutionary profiles of microbiota during aging across all age groups and focusing on analyzing significantly changed gut microbiota and their biological functions.Based on clues obtained from the above analysis that microbiota with fatty acid oxidation function was closely related to aging,and validation was conducted using fatty acid oxidation inhibitor TMZ in aging animal models.RESULTS Multicohort analysis revealed that gut microbial diversity follows a nonlinear trajectory,initially increasing until age 10,remaining relatively stable until approximately 70 years and declining thereafter.Functional enrichment analysis demonstrated a significant,age-associated increase in lipid metabolism pathways in both human and animal models,which was consistent with marked changes in abundance in the gut microbiota involved in lipid metabolism such as Luteipulveratus(P<0.05).TMZ,a fatty acid oxidation inhibitor,reshaped the gut microbiota structure and suppressed the abundance of lipid metabolism-associated gut microbiota in aging rats.Further molecular validation confirmed that the TMZ inhibited fatty acidβ-oxidation and significantly downregulated the expression levels of key senescence marker proteins and genes.CONCLUSION In conclusion,gut microbiota undergoes age-dependent remodeling,with significant enrichment of the fatty acid oxidation-related microbiome.The fatty acid oxidation inhibitor TMZ may attenuate aging phenotype through the dual modulation of gut microbial composition and lipid metabolism and may provide an antiaging strategy. 展开更多
关键词 Intestinal microbiota Dysbiosis Lipid metabolism Trimetazidine Senescence
暂未订购 下载PDF
人类长寿的机制与长寿医学 认领 引用 被引量：1
2
作者 何琪杨 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2026年第1期3-10,共8页
在积极应对人口老龄化的挑战中,从健康老龄化典范的百岁老人入手,深入研究长寿机制,无论是改善晚年健康、还是减轻经济负担,均具有重大的理论和实际意义。百岁老人表现为患慢性病少和健康韧性强,其机制与长寿基因、性别、心理、肠道菌... 在积极应对人口老龄化的挑战中,从健康老龄化典范的百岁老人入手,深入研究长寿机制,无论是改善晚年健康、还是减轻经济负担,均具有重大的理论和实际意义。百岁老人表现为患慢性病少和健康韧性强,其机制与长寿基因、性别、心理、肠道菌群、经济状况和生活环境等相关。本文还对人类个体极限寿命进行了探讨,强调基于科学证据的寿命极限115岁的可靠性。长寿机制与长寿基因密切相关,要活到百岁,基因起决定性的作用。长寿机制研究成果应用的场景是长寿诊所,长寿医学是研究如何延长健康寿命的新学科。本文对长寿医学的发展前景进行了探讨。 展开更多
关键词 长寿机制 百岁老人 寿命极限 长寿医学 长寿干预 健康韧性
暂未订购 下载PDF
Systematic review of mitochondrial dysfunction and oxidative stress in aging:A focus on neuromuscular junctions 认领 引用
3
作者 Senlin Chai Ning Zhang +8 位作者 Can Cui Zhengyuan Bao Qianjin Wang Wujian Lin Ronald Man Yeung Wong Sheung Wai Law Rebecca Schönmehl Christoph Brochhausen Wing Hoi Cheung 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1947-1960,共14页
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pa... Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pathological factor contributing to the progression of sarcopenia.However,the morphological and functional changes in mitochondria and their interplay in the degeneration of the neuromuscular junction during aging remain poorly understood.A defined systematic search of the Pub Med,Web of Science and Embase databases(last accessed on October 30,2024)was conducted with search terms including'mitochondria','aging'and'NMJ'.Clinical and preclinical studies of mitochondrial dysfunction and neuromuscular junction degeneration during aging.Twentyseven studies were included in this systematic review.This systematic review provides a summary of morphological,functional and biological changes in neuromuscular junction,mitochondrial morphology,biosynthesis,respiratory chain function,and mitophagy during aging.We focus on the interactions and mechanisms underlying the relationship between mitochondria and neuromuscular junctions during aging.Aging is characterized by significant reductions in mitochondrial fusion/fission cycles,biosynthesis,and mitochondrial quality control,which may lead to neuromuscular junction dysfunction,denervation and poor physical performance.Motor nerve terminals that exhibit redox sensitivity are among the first to exhibit abnormalities,ultimately leading to an early decline in muscle strength through impaired neuromuscular junction transmission function.Parg coactivator 1 alpha is a crucial molecule that regulates mitochondrial biogenesis and modulates various pathways,including the mitochondrial respiratory chain,energy deficiency,oxidative stress,and inflammation.Mitochondrial dysfunction is correlated with neuromuscular junction denervation and acetylcholine receptor fragmentation,resulting in muscle atrophy and a decrease in strength during aging.Physical therapy,pharmacotherapy,and gene therapy can alleviate the structural degeneration and functional deterioration of neuromuscular junction by restoring mitochondrial function.Therefore,mitochondria are considered potential targets for preserving neuromuscular junction morphology and function during aging to treat sarcopenia. 展开更多
关键词 aging mitochondrial dysfunction neuromuscular junction oxidative stress sarcopenia systematic review
暂未订购 下载PDF
Retrograde axonal transport of autophagic vesicles and dynein-dynactin protein interaction are attenuated during aging in the rat optic nerve in vivo 认领 引用
4
作者 Xiaoyue Luo Jiong Zhang +4 位作者 Johan Tolö Sebastian Kügler Uwe Michel Mathias Bähr Jan Christoph Koch 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3163-3170,共8页
Aging is characterized by a decreased autophagic activity contributing to the intracellular deposition of damaged organelles and macromolecules.Autophagy is particularly challenging in neurons since autophagic vesicle... Aging is characterized by a decreased autophagic activity contributing to the intracellular deposition of damaged organelles and macromolecules.Autophagy is particularly challenging in neurons since autophagic vesicles are formed at the axonal tip and must be transported to the soma where final degradation occurs.Here,we examined if axonal transport of autophagic vesicles is altered during aging.We employed two-photon microscopy for in vivo imaging in the optic nerve of young and aged rats.In old animals(>18 months old),retrograde autophagic vesicle transport was significantly reduced with regard to motility and velocity.While activation of autophagy was decreased,expression of key proteins of the autophagy-lysosomal pathway including p62 and procathepsin D and the number of autophagolysosomes was increased.Maturation of autophagic vesicles was shifted to more distal regions of the axon and axonal lysosomal clearing was impaired.In a pull-down assay,the protein binding between dynein and dynactin was decreased by half,which could explain the retrograde axonal transport effects.Taken together,retrograde axonal autophagic vesicle transport in vivo is diminished during aging accompanied by decreased autophagy activation,alterations of the lysosomal pathway,and a reduced dynein-dynactin binding. 展开更多
关键词 aging autophagic vesicles autophagy autophagy-lysosomal pathway axonal transport dynein optic nerve p150Glued retrograde transport two-photon microscopy
暂未订购 下载PDF
长期耐力运动对自然衰老小鼠kl/FGF23轴及钙磷代谢的影响 认领 引用
5
作者 彭团辉 宋洪明 +2 位作者 杨玲 丁小歌 蒙鹏骏 《中国组织工程研究》 CAS 北大核心 2026年第5期1089-1095,共7页
背景:研究表明矿物质代谢紊乱可能是导致早衰的原因,而kl/FGF23轴在矿物质代谢过程中发挥重要的作用。目的:探究长期耐力运动对自然衰老小鼠kl/FGF23轴的影响,观察长期耐力运动对钙磷代谢的影响,从而为长期耐力运动对自然衰老的影响提... 背景:研究表明矿物质代谢紊乱可能是导致早衰的原因,而kl/FGF23轴在矿物质代谢过程中发挥重要的作用。目的:探究长期耐力运动对自然衰老小鼠kl/FGF23轴的影响,观察长期耐力运动对钙磷代谢的影响,从而为长期耐力运动对自然衰老的影响提供参考。方法:5周龄SPF级雄性balb/c小鼠22只,随机分为3组:年轻安静对照组,自然衰老安静组和自然衰老运动组。随后将年轻安静对照组小鼠立即处死取材;自然衰老安静组小鼠正常饲养,直至60周龄取材;自然衰老运动组小鼠进行1周适应性运动后,进行最大跑速测试,根据最大跑速的70%设定正式运动速度,每周一,三,五进行运动,每次50 min。每隔8周重新进行一次最大跑速测试,调整正式运动速度,直至60周龄取材。检测小鼠血清和骨钙磷浓度;Western Blot法测肾脏Klotho蛋白表达。酶联免疫法检测股骨成纤维细胞生长因子23水平、肾脏成纤维细胞生长因子受体1、1α-羟化酶水平及血清1,25(OH)2D3水平。结果与结论:①与年轻安静对照组相比,自然衰老安静组小鼠血钙磷浓度无明显变化(P>0.05),但骨钙磷浓度出现显著降低(P0.05),同时骨钙磷浓度明显增加(P0.05)。③与年轻安静对照组相比,自然衰老安静组小鼠肾脏Klotho蛋白表达量、肾脏成纤维细胞生长因子受体1、1α-羟化酶质量浓度及血清1,25(OH)2D3质量浓度显著降低(P<0.05,P<0.01);与自然衰老安静组相比,自然衰老运动组小鼠上述4项指标水平显著增加(P<0.05,P<0.01)。④结论:长期耐力运动可以通过kl/FGF23轴,对Klotho蛋白和成纤维细胞生长因子23进行调节,从而影响1α-羟化酶的表达及1,25(OH)2D3的水平,进而调节机体的钙磷代谢,尤其是磷酸盐代谢,表明长期耐力运动可以通过kl/FGF23轴延缓机体自然衰老。 展开更多
关键词 自然衰老小鼠 肾脏Klotho 成纤维细胞生长因子23 kl/FGF23轴 钙磷代谢
暂未订购 下载PDF
Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction:Insights from Glycomics and Transcriptomics 认领 引用
6
作者 Huijuan Zhao Jiteng Fan +7 位作者 Jing Han Wenjun Qin Jichen Sha Weilong Zhang Yong Gu Xiaonan Ma Jianxin Gu Shifang Ren 《Engineering》 SCIE EI CSCD 2026年第2期113-125,共13页
Immunoglobulin G(IgG)N-glycans are associated with aging.In this study,we introduce a novel strategy for discovering aging-associated IgG glycans and establish a prediction model on the basis of their absolute concent... Immunoglobulin G(IgG)N-glycans are associated with aging.In this study,we introduce a novel strategy for discovering aging-associated IgG glycans and establish a prediction model on the basis of their absolute concentration alterations.We employed glycomic quantification technology to identify alterations in the amount of IgG glycan in natural aging and antiaging(caloric restriction(CR))models and discovered aging-related glycans.The glycomic analysis revealed key features:downregulation of the bisected glycan GP3(F(6)A2B)and upregulation of the digalactosylated glycan GP8(F(6)A2G2).These glycan changes showed significant fold changes from an early stage.Using external standards of these two glycans,we subsequently measured their absolute concentrations,allowing for us to establish a predictive model,abGlycoAge,for biological aging.The abGlycoAge index suggested a younger state under CR,with an average age reduction of 3.9–14.0 weeks.Additionally,RNA sequencing of splenic B cells revealed that Derl3,Smarcb1,Ankrd55,Tbkbp1,and Slc38a10 may contribute to alterations in GP3 and GP8 during the aging process.In a preliminary therapeutic study,we tested IgG modified with young signature Nglycans(IgG-Ny).High-dose IgG-Ny showed promising results,alleviating aging-related physiological declines,including reductions in inflammatory markers and improvements in organ senescence,particularly in the brain,kidney,and lungs.This research provides new insights into glycan changes during aging and lays the groundwork for potential antiaging therapies.GP3 and GP8 may serve as biomarkers for aging,offering new perspectives on aging mechanisms and therapeutic approaches. 展开更多
关键词 Absolute quantification Immunoglobulin G N-glycome Aging Glycan biomarker
暂未订购 下载PDF
长寿抗衰干预:基于衰老机制的应用前景 认领 引用
7
作者 何琪杨 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2026年第1期1-2,共2页
衰老机制的研究成果,在人体应用中有2种学科途径:老年医学和长寿医学。经过多年的研究,靶向衰老细胞的衰老干预研究,在小鼠体内取得良好的结果,但转化到人体效果有限。本专题对相关的研究,从不同角度进行了综述和总结,展示了人体应用的... 衰老机制的研究成果,在人体应用中有2种学科途径:老年医学和长寿医学。经过多年的研究,靶向衰老细胞的衰老干预研究,在小鼠体内取得良好的结果,但转化到人体效果有限。本专题对相关的研究,从不同角度进行了综述和总结,展示了人体应用的前景。在未来的研究中,可能需要回答衰老机制的一些基本问题,尤其是人体老年期的衰老细胞的动态和数量变化,从而为临床应用奠定坚实的理论基础。 展开更多
关键词 衰老机制 老年科学 长寿抗衰 转化应用
暂未订购 下载PDF
序言 认领 引用
8
作者 刘光慧 《生命科学》 CSCD 2026年第6期955-955,共1页
衰老是生命过程中最为复杂且普遍的生物学现象之一。它并非简单的功能衰退,而是由多层次、多系统相互作用构成的动态网络过程。传统观点倾向于将衰老视为各器官独立的退行性变化,而近年来的研究揭示,衰老具有显著的系统性特征——不同... 衰老是生命过程中最为复杂且普遍的生物学现象之一。它并非简单的功能衰退,而是由多层次、多系统相互作用构成的动态网络过程。传统观点倾向于将衰老视为各器官独立的退行性变化,而近年来的研究揭示,衰老具有显著的系统性特征——不同器官的衰老并非孤立事件,而是通过多种介质相互耦合、级联放大的系统性过程。 展开更多
关键词 动态网络过程 多系统 生物学现象 衰老 多层次
暂未订购 下载PDF
运动·肠道菌群与衰老 认领 引用 被引量：1
9
作者 王印凤 要俪娟 +1 位作者 马震南 陈乐琴 《中国组织工程研究》 CAS 北大核心 2026年第24期6337-6344,共8页
背景:运动作为经典的抗衰老干预手段,其益处已得到广泛认可。肠道菌群中多种微生物的稳态平衡能间接调控衰老,而运动和肠道菌群的双向联系能共同影响衰老的进程。目的:梳理运动、肠道菌群及二者相互作用对衰老的影响,探讨其中具体的生... 背景:运动作为经典的抗衰老干预手段,其益处已得到广泛认可。肠道菌群中多种微生物的稳态平衡能间接调控衰老,而运动和肠道菌群的双向联系能共同影响衰老的进程。目的:梳理运动、肠道菌群及二者相互作用对衰老的影响,探讨其中具体的生理作用机制。方法:应用计算机检索中国知网、万方、维普、PubMed、MedReading、Web of Science数据库,文献检索时限为1976-01-01/2025-02-28,搜集运动、肠道菌群对衰老影响的相关研究,中文检索词为“肠道菌群,运动,衰老,有氧运动,抗阻运动,低等强度运动,中等强度运动,高等强度运动”等,英文检索词为“intestinal flora,gut microbiota,physical exercise,age,aerobic exercise,resistance exercise,low intensity exercise,moderate intensity exercise,high intensity exercise”等。结果与结论:①运动、肠道菌群分别是干预衰老的手段之一,而运动和肠道菌群共同干预衰老的效益更加明显;②运动可改变肠道菌群的组成和功能,刺激肠道生成短链脂肪酸,调控宿主的代谢、免疫功能,减少炎症反应,促进维生素和神经递质的合成;③不同运动方式调控的肠道菌群对衰老影响的具体表现形式不同;④运动调控的不同肠-器官轴对衰老的影响不同。 展开更多
关键词 肠道菌群 运动 衰老 有益菌 菌群多样性 老年群体 肠-器官轴 靶向干预
暂未订购 下载PDF
肠道菌群在衰老过程中的多系统调控研究进展 认领 引用 被引量：1
10
作者 陈香 徐玲玲 +2 位作者 陈佳欣 章迎春 程静屏 《武汉大学学报（医学版）》 CAS 2026年第1期131-136,142,共6页
随着全球人口加速老龄化,增龄相关性疾病已成为重大公共卫生挑战。肠道菌群作为人体微生态系统的关键组成部分,在肌少症、认知衰弱和血管衰老等疾病的发生发展中发挥了至关重要的作用。研究表明,肠道菌群通过代谢调节、免疫炎症反应和... 随着全球人口加速老龄化,增龄相关性疾病已成为重大公共卫生挑战。肠道菌群作为人体微生态系统的关键组成部分,在肌少症、认知衰弱和血管衰老等疾病的发生发展中发挥了至关重要的作用。研究表明,肠道菌群通过代谢调节、免疫炎症反应和神经信号通路等多种机制,深刻影响机体多系统健康。本文综合评价了肠道菌群在增龄相关性疾病中的作用机制及研究进展,重点关注肠道菌群与肌肉、认知功能和血管系统的相互作用,通过探讨肠道菌群改变的机制及其对多系统健康的影响,评估当前的干预策略并展望未来的研究方向。 展开更多
关键词 衰老 肠道菌群 肌少症 认知衰弱 血管衰老
暂未订购 下载PDF
Deep Reinforcement Learning-Driven Multi-Omics Integration for Constructing gtAge:A Novel Aging Clock from the IgG N-Glycome and Blood Transcriptome 认领 引用
11
作者 Yao Xia Syed Mohammed Shamsul Islam +3 位作者 Xingang Li Abdul Baten Xuerui Tan Wei Wang 《Engineering》 SCIE EI CSCD 2026年第2期100-112,共13页
Previous studies have demonstrated that the immunoglobulin G(IgG)N-glycome and transcriptome are potential biochemical signatures of chronological and biological ages,and several aging clocks have been developed.By in... Previous studies have demonstrated that the immunoglobulin G(IgG)N-glycome and transcriptome are potential biochemical signatures of chronological and biological ages,and several aging clocks have been developed.By integrating the IgG N-glycome and transcriptome,we propose a novel aging clock,gtAge.We developed a deep reinforcement learning-based multiomics integration method called AlphaSnake.The results showed that AlphaSnake achieved a predicted coefficient of determination(R2)value of0.853,outperforming the concatenation-based integration method(R2=0.820)The gtAge estimated by AlphaSnake explained up to 85.3%of the variance in chronological age,which was higher than that in age predicted from IgG N-glycome solely(gAge;R2=0.290)and age predicted from transcriptome solely(tAge;R2=0.812).We also found that the delta age-the difference between the predicted age and chronological age-was associated with several age-related phenotypes.Both delta gtAge and tAge were negatively associated with high-density lipoprotein(p=0.02 and p=0.022,respectively),whereas delta gAge was positively correlated with cholesterol(p=0.006),triglyceride(p=0.002),fasting plasma glucose(p=0.014),low-density lipoprotein(p=0.006),and glycated hemoglobin(p=0.039).These findings suggest that gtAge,tAge,and gAge are potential biomarkers for biological age. 展开更多
关键词 Aging clock IgG N-glycome Transcriptome Multiomics integration Deep reinforcement learning Biological age
暂未订购 下载PDF
不同类型胶原蛋白在皮肤衰老中的作用及其研究进展 认领 引用
12
作者 李亚茹 孙畅 +3 位作者 刘子滨 罗永康 姜燕飞 赵春月 《生物工程学报》 EI CAS CSCD 北大核心 2026年第2期533-546,共14页
胶原蛋白的流失是皮肤衰老的核心因素之一,作为人体含量最丰富的蛋白质,其动态平衡对维持皮肤结构功能至关重要。本文系统介绍了在皮肤衰老过程中发挥关键作用的Ⅰ型、Ⅲ型、Ⅳ型、Ⅶ型和ⅩⅦ型胶原蛋白的功能及其作用机制,Ⅰ型胶原蛋... 胶原蛋白的流失是皮肤衰老的核心因素之一,作为人体含量最丰富的蛋白质,其动态平衡对维持皮肤结构功能至关重要。本文系统介绍了在皮肤衰老过程中发挥关键作用的Ⅰ型、Ⅲ型、Ⅳ型、Ⅶ型和ⅩⅦ型胶原蛋白的功能及其作用机制,Ⅰ型胶原蛋白主要提供真皮层机械支撑力,Ⅲ型胶原蛋白增强皮肤弹性并协同屏障修复,Ⅳ型胶原蛋白维持基底膜稳定,Ⅶ型胶原蛋白介导表皮-真皮锚定,ⅩⅦ型胶原蛋白则调控表皮干细胞稳态;同时深入论述了基于胶原蛋白流失机制的抗衰老策略研究进展,包括应用抗氧化剂减轻氧化损伤对胶原的破坏,利用新型活性成分刺激胶原合成,以及通过补充胶原蛋白肽等方式促进内源性胶原再生。本文总结了不同类型胶原蛋白在皮肤衰老中的功能网络,为开发多维度、协同增效的抗衰老策略提供了新的视角和思路。 展开更多
关键词 胶原蛋白 皮肤衰老 抗氧化 胶原蛋白肽 抗衰老策略
暂未订购 下载PDF
Leveraging mitochondrial stress to improve healthy aging 认领 引用
13
作者 Abril Gorgori-Gonzalez Silvana Soto-Rodriguez +5 位作者 Eva Tamayo-Torres Esther Garcia-Dominguez Vicente Sebastia Juan Gambini Gloria Olaso-Gonzalez Maria Carmen Gomez-Cabrera 《Sports Medicine and Health Science》 CAS CSCD 2026年第1期23-33,共11页
Aging is characterized by a progressive decline in physiological function,driven by intrinsic mechanisms(primary aging)and modifiable factors(secondary aging),ultimately leading to multimorbidity,disability,and mortal... Aging is characterized by a progressive decline in physiological function,driven by intrinsic mechanisms(primary aging)and modifiable factors(secondary aging),ultimately leading to multimorbidity,disability,and mortality.Mitochondrial dysfunction,a major hallmark of aging,plays a central role in the loss of muscle mass and strength observed in frailty and sarcopenia.With age,mitochondrial quality control processes,including biogenesis,mitophagy,and dynamics,become dysregulated,impairing energy metabolism and muscle homeostasis.Mitochondrial dysfunction correlates with clinical biomarkers of sarcopenia and frailty,such as the decrease in walking speed and muscle strength,making it a therapeutic target for mitohormesis-based strategies aimed at preserving functional capacity.Mitohormetic agents induce reversible mitochondrial stress,triggering adaptive responses that enhance function.Among these interventions,physical exercise,particularly endurance and resistance training(RT),has been reported to be among the most effective,as it may modulate mitochondrial biogenesis,dynamics,and mitophagy through increases in proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α)and mitochondrial transcription factor A(TFAM)expression,mitochondrial deoxyribonucleic acid(mtDNA)copy number,and mitochondrial content.Chronic RT can also elevate fusion and fission markers,potentially as a compensatory mechanism to mitigate mitochondrial damage.Apart from exercise,mitohormetic compounds such as harmol and piceid are emerging as promising supplements in the aging field.By modulating mitochondrial bioenergetics and dynamics,they may complement lifestyle-based interventions to improve mitochondrial fitness and extend health span. 展开更多
关键词 Frailty Muscle homeostasis Mitochondrial dysfunction Mitohormesis Resistance training Phytochemicals
暂未订购 下载PDF
Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice 认领 引用
14
作者 Khan-Erdene Tsolmon Zolzaya Bavuu +3 位作者 Yun-Bae Kim Solar Sora Kim Heon-Sang Jeong Dongsun Park 《World Journal of Stem Cells》 SCIE 2026年第4期157-170,共14页
BACRGROUIND Anti-aging for the preservation and recovery of physical and brain functions may be a major topic of regenerative medicine in the super-aging society.Stem cells and their secretory active molecules can pla... BACRGROUIND Anti-aging for the preservation and recovery of physical and brain functions may be a major topic of regenerative medicine in the super-aging society.Stem cells and their secretory active molecules can play a central role of regenerative medicine.AIM To investigate whether extracellular vesicles(EVs)from amniotic membrane stem cells(AMSCs)enhance physical activity,including stamina,and cognitive function in a mouse model of facilitated brain-aging,and to elucidate underlying mechanisms.METHODS EVs were collected from conditioned media of AMSCs after hypoxic(2%O2,5%CO2)cultivation for 3 days.The size and composition of EVs was analyzed via nanoparticle-tracking analysis and proteome/lipidome profiles,and functional molecules such as growth factors and neurotrophic factors were analyzed via enzyme linked immunosorbent assay.Male ICR mice were subcutaneously administered with D-galactose(300 mg/kg)for 6 weeks to induce facilitated aging,during which intravenously injected with EVs(6×108exosome particles/body)at weeks 0,2,4,and 6.Physical activity and cognitive function were assessed through Rota-rod,forced swimming and passive avoidance performances,respectively.To clarify underlying mechanisms,acetylcholine(ACh),brain-derived neurotrophic factor(BDNF),sirtuin 1(SIRT1),glial fibrillary acid protein(GFAP),glycogen,and thiobarbituric acid-reactive substances(TBARS)were analyzed in the brain and muscles.RESULTS Six-week injection of D-galactose decreased physical activity and impaired learning and memory function,along with the reduced ACh,BDNF,SIRT1,and glycogen in the brain and muscles,whereas brain GFAP and muscular TBARS increased.However,EV treatment recovered the D-galactose-induced neurobehavioral deficits not only by increasing BDNF and SIRT1(regulating neuro-muscular adaptation and function)and enhancing brain ACh(governing memory acquisition),but also by restoring muscular glycogen(an energy source)and attenuating brain GFAP and muscular TBARS(inflammatory and oxidative injury markers).CONCLUSION EVs from AMSCs restored cognitive function of mice with facilitated brain-aging by increasing ACh,BDNF,and SIRT1.EVs also enhanced stamina not only by attenuating tissue injury,but also by strengthening the muscles through the production of glycogen and BDNF. 展开更多
关键词 Aging Physical activity Cognitive function Amniotic membrane stem cell Extracellular vesicle Growth factor Neurotrophic factor
暂未订购 下载PDF
Proteostasis decline and endoplasmic reticulum stress in aging:Implications for cellular senescence and senescence-associated secretory phenotype regulation 认领 引用
15
作者 Philippe Pihán Lisa M.Ellerby Claudio Hetz 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期2934-2935,共2页
Aging is a universal biological process characterized by the progressive decline in cellular and tissue function,representing the main risk factor for the development of most chronic human diseases.At the cellular lev... Aging is a universal biological process characterized by the progressive decline in cellular and tissue function,representing the main risk factor for the development of most chronic human diseases.At the cellular level,one hallmark of aging is the accumulation of senescent cells—non-dividing yet metabolically active cells that adopt a unique phenotype,including the senescence-associated secretory phenotype(SASP)(Wang et al.,2024). 展开更多
关键词 proteostasis decline senescence associated secretory phenotype cellular tissue endoplasmic reticulum stress senescent cells non dividing cellular senescence aging
暂未订购 下载PDF
内源性代谢分子调控衰老的机制与干预前景 认领 引用
16
作者 张金星 袁蓉 +3 位作者 信琪琪 缪宇 崔钊 丛伟红 《中国医药导报》 CAS 2026年第9期191-196,共6页
衰老是机体生理功能随年龄增长而发生系统性衰退的复杂过程,与多种慢性疾病的发生密切相关,对全球公共卫生构成严峻挑战。近年来,越来越多研究日益发现内源性代谢分子在衰老调控中的核心作用,其稳态失衡被视为驱动衰老进程的关键环节。... 衰老是机体生理功能随年龄增长而发生系统性衰退的复杂过程,与多种慢性疾病的发生密切相关,对全球公共卫生构成严峻挑战。近年来,越来越多研究日益发现内源性代谢分子在衰老调控中的核心作用,其稳态失衡被视为驱动衰老进程的关键环节。本文系统综述糖类、脂质、氨基酸、核苷酸、维生素及神经递质等各类内源性代谢分子调控衰老的核心机制。这些分子不仅是能量和物质代谢的参与者,而且是重要的信号介质,通过调节能量感应、表观遗传、氧化还原、炎症反应及干细胞功能等多维度过程,深刻影响细胞与器官的衰老进程。其作为“桥梁分子”,将原本孤立的衰老标志紧密联结成一个高度互联的代谢调控网络。基于此,通过干预内源性代谢分子以重建机体稳态,可为实现健康老龄化和防治年龄相关疾病提供新的理论基础与潜在解决方案。 展开更多
关键词 内源性代谢分子 衰老机制 代谢调控 生物标志物
暂未订购 下载PDF
生物学年龄评估衰老及其临床应用 认领 引用
17
作者 黄丹青 郭婧 +1 位作者 郭燕 杨铁林 《遗传》 CAS CSCD 北大核心 2026年第7期690-700,共11页
随着全球人口老龄化加剧,开发能够精准量化个体衰老状态、突破时序年龄评估局限的技术方法,已成为衰老研究与精准医学的重要需求。生物学年龄通过整合多组学数据与器官特异性生物标志物,为评估个体真实生理衰老进程及疾病风险提供了重... 随着全球人口老龄化加剧,开发能够精准量化个体衰老状态、突破时序年龄评估局限的技术方法,已成为衰老研究与精准医学的重要需求。生物学年龄通过整合多组学数据与器官特异性生物标志物,为评估个体真实生理衰老进程及疾病风险提供了重要工具。本文系统综述了衰老评估方法的发展,重点阐述了基于表观遗传学标志物以及转录组学、蛋白质组学和代谢组学标志物的衰老时钟构建策略及其演变,并探讨了基于影像学数据与多组学数据整合的器官特异性衰老评估新方法。结合这些方法在衰老相关疾病早期筛查与风险分层、个性化干预及健康管理中的临床应用证据,本文还进一步阐明了生物学年龄在精准衰老评估与干预中的重要价值与临床转化前景。 展开更多
关键词 衰老 生物学年龄 生物标志物 多组学 临床应用
暂未订购 下载PDF
An exploration study on the relationship between chronological and perceived age in Chinese women with systematic validation of a new method for perceived age determination 认领 引用
18
作者 Yuanyuan Diao Qianxin Zhu +1 位作者 Guanghan Zhao Liang Chen 《Journal of Dermatologic Science and Cosmetic Technology》 2026年第1期84-91,共8页
Background:Skin aging is a complex biological process influenced by intrinsic and extrinsic factors,leading to various aging manifestations.Defining facial aging is especially important for the selection of anti-aging... Background:Skin aging is a complex biological process influenced by intrinsic and extrinsic factors,leading to various aging manifestations.Defining facial aging is especially important for the selection of anti-aging products.Objectives:This study aimed to evaluate the relationship between the severity of aging features along with chronological age and perceived age,and to develop a method of determining perceived age by non-expert assessors.Materials and methods:A total of 308 Chinese females aged 15-65 years underwent expert aging features scoring,facial image acquisition,and age perception on acquired photographs.The facial characteristics and facial areas that influenced the age perception were collected by questionnaire.Subjects were grouped based on the deviation between their perceived and chronological age,and the facial aging features were compared among these groups.Results:The perceived age of Chinese women was on average 1.6 years older than their chronological age.The severities of aging features demonstrated strong correlations with perceived age,paralleling their correlations with chronological age.Nasolabial fold,marionette fold,tightness of facial contour,poor skin evenness,and poor skin radiance were common key factors for age perception.Additionally,various aging features demonstrated predominant uniqueness among different age ranges.Conclusions:Perceived age tends to exceed chronological age.The age perception is correlated to the manifestation of aging features.The method developed in this study to determine perceived age is applicable for evaluating the benefits of anti-aging products and delivering valuable guidance for skin care product development on targeting specific aging features and customizing strategies for consumer groups with older perceived age. 展开更多
关键词 Facial aging features Chinese women Chronological age Perceived age Signs of aging
暂未订购 下载PDF
干预衰老的代谢物研究现状 认领 引用
19
作者 谢伟恒 杨萌 刘新光 《生命的化学》 CAS 2026年第5期865-876,共12页
衰老是自然界普遍存在的现象。衰老伴随着组织和器官功能的逐渐衰退,最终导致生物体死亡。机体代谢紊乱与多种衰老相关疾病的发生发展密切相关,可通过促进慢性炎症、氧化应激、胰岛素抵抗和线粒体功能障碍等途径加速衰老进程。随着代谢... 衰老是自然界普遍存在的现象。衰老伴随着组织和器官功能的逐渐衰退,最终导致生物体死亡。机体代谢紊乱与多种衰老相关疾病的发生发展密切相关,可通过促进慢性炎症、氧化应激、胰岛素抵抗和线粒体功能障碍等途径加速衰老进程。随着代谢物在衰老中的作用逐渐被揭示,以代谢物为靶点的干预措施成为抗衰老研究的重要关注点之一。除了研究比较多的烟酰胺腺嘌呤二核苷酸和牛磺酸,最新研究发现,亚精胺、瓜氨酸、麦角硫因以及延胡索酸四种代谢物在衰老中也发挥了重要作用,且多数代谢物展现出抗衰老潜力。本文概述了以上六种抗衰老代谢物的最新研究进展,归纳总结了代谢物的作用机制,并对抗衰老代谢物研究结果中存在的矛盾进行了讨论。本文对抗衰老代谢物进行了深入探讨,有望为衰老相关疾病的治疗提供理论支撑。 展开更多
关键词 衰老 代谢物 牛磺酸 NAD+ 亚精胺 瓜氨酸 麦角硫因 延胡索酸
暂未订购 下载PDF
细胞水平体外衰老模型的构建策略与研究进展 认领 引用
20
作者 刘建玲 李双 +3 位作者 李京 张佳燚 孙璐瑶 程宇 《河北师范大学学报（自然科学版）》 CAS 2026年第4期349-363,共15页
随着科技进步,人类寿命延长,衰老相关问题备受关注.衰老作为现代医学面临的重大挑战,是由细胞衰老、基因组变异、端粒缩短、线粒体功能障碍等多因素驱动的复杂过程,与心血管疾病、癌症、阿尔茨海默病等多种老年疾病密切相关.其中,细胞... 随着科技进步,人类寿命延长,衰老相关问题备受关注.衰老作为现代医学面临的重大挑战,是由细胞衰老、基因组变异、端粒缩短、线粒体功能障碍等多因素驱动的复杂过程,与心血管疾病、癌症、阿尔茨海默病等多种老年疾病密切相关.其中,细胞衰老通过产生衰老相关分泌表型(senescence-associated secretory phenotype,SASP)破坏组织稳态,被视为衰老及年龄相关疾病的关键驱动因素.体外衰老模型的构建对揭示衰老机制及开发干预策略具有重要意义.根据诱导因素,衰老可分为4大核心类型:复制性衰老(replicative senescence,RS)、癌基因性衰老(oncogene-induced senescence,OIS)、应激诱导早衰(stress-induced premature senescence,SIPS)和治疗诱导衰老(treatment induced senescence,TIS).由于其关键机制尚不明确,且人类受试者研究受限(伦理、技术),建立可靠的衰老模型至关重要,而体外模型通过模拟细胞衰老过程,为剖析衰老机制、评估抗衰老疗法提供了可靠途径,有助于推动衰老相关疾病的干预研究.笔者聚焦多种体外衰老模型构建方法(辐射、药物作用、线粒体损伤、三维培养、器官芯片以及微生理系统和人工智能应用等),体现衰老的重要特征,以期为衰老研究提供新视角. 展开更多
关键词 衰老 体外 衰老模型
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 127 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈