BACKGROUND Clinically relevant postoperative pancreatic fistula(CR-POPF)is a critical complication of splenectomy,particularly in patients with cirrhosis,splenomegaly,and hypersplenism.However,there is a lack of compr...BACKGROUND Clinically relevant postoperative pancreatic fistula(CR-POPF)is a critical complication of splenectomy,particularly in patients with cirrhosis,splenomegaly,and hypersplenism.However,there is a lack of comprehensive risk assessment models.AIM To identify independent risk factors for CR-POPF after splenectomy in this cohort and to develop a clinically useful predictive nomogram.METHODS This retrospective study included 186 patients who underwent splenectomy for cirrhotic splenomegaly with hypersplenism at our institution,between January 2019 and December 2024.PF was diagnosed and graded according to the 2016 International Study Group on Pancreatic Fistulas criteria.Univariate and multivariate least absolute shrinkage and selection operator-penalized logistic regression analyses were performed to identify independent risk factors.A receiver operating characteristic curve,calibration curves,and decision curve analysis.RESULTS Of the 186 patients,21 developed biochemical leak,and 6 developed CR-POPF,including 4 grade B and 2 grade C.Multivariate least absolute shrinkage and selection operator-penalized logistic analysis revealed that body mass index(BMI)[odds ratio=3.578,95%confidence interval(CI):1.156-11.080;P=0.027]and splenic thickness(odds ratio=1.250;95%CI:1.014-1.542;P=0.037)were independent risk factors for CR-POPF.The nomogram integrating these factors demonstrated excellent discriminative ability(area under the receiver operating characteristic curve=0.816,95%CI:0.500-0.993),good calibration(Hosmer-Lemeshow statistic=0.027,degrees of freedom=3,P=0.999>0.05),and favorable clinical utility(positive net benefit across a threshold probability range of approximately 0%to 99%in the decision curve analysis).PF grade analysis showed significant differences in BMI and pancreatic texture(P<0.05).CONCLUSION This study identified BMI and splenic thickness as independent risk factors for CR-POPF after splenectomy in patients with cirrhosis with splenomegaly.The developed nomogram provides a reliable tool for individualized risk prediction,facilitating targeted perioperative management to reduce CR-POPF incidence and improve patient outcomes.展开更多
Gilbert综合征(Gilbert syndrome,GS)是因尿苷二磷酸葡萄糖醛酸转移酶1家族成员A1(UDPglucuronosyltransferase family 1 member A1,UGT1A1)基因突变导致尿苷二磷酸葡萄糖醛酸转移酶(uridine diphosphate glucuronosyltransferase,UGT酶...Gilbert综合征(Gilbert syndrome,GS)是因尿苷二磷酸葡萄糖醛酸转移酶1家族成员A1(UDPglucuronosyltransferase family 1 member A1,UGT1A1)基因突变导致尿苷二磷酸葡萄糖醛酸转移酶(uridine diphosphate glucuronosyltransferase,UGT酶)活性降低、以慢性非结合性高胆红素血症为特征的遗传性疾病,患者典型临床表现为间歇性黄疸,转氨酶正常,确诊依赖UGT1A1基因检测[1-2]。遗传性球形红细胞增多症(hereditary spherocytosis,HS)是红细胞膜蛋白基因突变导致红细胞球形化并在脾脏破坏增加,进而引发的溶血性疾病,患者典型表现为贫血、黄疸和脾大,可有外周血球形红细胞增多、渗透脆性增加,基因检测可明确ANK1、SPTA1等突变[3]。两病共患时可因临床表现重叠发生误诊或漏诊。现对我单位收治的1例GS共患HS行腹腔镜下脾切除的患者诊治经过总结报道如下。展开更多
BACKGROUND Traumatic splenic rupture is the most common solid organ injury in blunt abdominal trauma,and splenectomy remains a critical intervention for patients with hemodynamic instability.The shock index(SI),a simp...BACKGROUND Traumatic splenic rupture is the most common solid organ injury in blunt abdominal trauma,and splenectomy remains a critical intervention for patients with hemodynamic instability.The shock index(SI),a simple hemodynamic indicator,has demonstrated significant value in prognostic assessment of trauma patients.However,studies on the predictive value of SI in patients undergoing splenectomy for traumatic splenic rupture are relatively limited.AIM To investigate the predictive value of preoperative SI on postoperative complications,mortality,and long-term survival in patients with traumatic splenic rupture undergoing splenectomy,and to construct a prognostic prediction model based on SI.METHODS Clinical data of 212 patients with traumatic splenic rupture who underwent splenectomy from January 2020 to January 2025 were retrospectively analyzed.Patients were divided into low SI group(SI<0.9,n=78),moderate SI group(0.9≤SI<1.3,n=89),and high SI group(SI≥1.3,n=45)based on preoperative SI(SI=heart rate/systolic blood pressure).Basic information,clinical indicators at admission,laboratory tests,imaging examinations,surgery-related indicators,and prognostic data were collected.The Clavien-Dindo grading system was used to assess postoperative complications.Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for severe postoperative complications.A prognostic prediction model was constructed and its discriminative ability was evaluated using receiver operating characteristic curves.Kaplan-Meier method and Cox regression model were used for survival analysis.RESULTS With increasing SI,patients showed significantly decreased blood pressure,significantly increased heart rate and respiratory rate,more severe splenic injury,and significantly increased intraoperative blood loss and transfusion volume(all P<0.001).The incidence of severe postoperative complications in the high SI group(26.7%)was significantly higher than that in the moderate SI group(12.4%)and low SI group(3.8%)(P<0.001).Multivariate logistic regression analysis showed that SI[odds ratio(OR)=2.34,95%confidence interval(CI):1.25-4.38,P=0.008],splenic injury grade≥IV(OR=2.97,95%CI:1.28-6.86,P=0.011),hemoglobin≤90 g/L(OR=3.14,95%CI:1.40-7.07,P=0.005),lactate level≥4.0 mmol/L(OR=3.97,95%CI:1.76-8.92,P=0.001),and massive intraperitoneal hemorrhage(OR=2.43,95%CI:1.02-5.78,P=0.045)were independent risk factors for severe postoperative complications.The multivariate prediction model based on SI had an area under the curve of 0.847(95%CI:0.789-0.905)for predicting severe postoperative complications,which was significantly superior to SI alone(area under the curve=0.782,P=0.033).The optimal cutoff value of SI for predicting severe postoperative complications was 1.15,with sensitivity of 76.9%and specificity of 81.2%.Survival analysis showed that 1-year survival rates in the low,moderate,and high SI groups were 98.7%,96.6%,and 86.7%,respectively(P=0.015).Cox regression analysis confirmed that SI was an independent risk factor affecting patient survival(hazard ratio=1.85,95%CI:1.16-2.95,P=0.010).CONCLUSION Preoperative SI is an important predictor of prognosis in patients with traumatic splenic rupture undergoing splenectomy,which can effectively identify high-risk patients and guide clinical decision-making.展开更多
BACKGROUND Splenectomy is an effective yet invasive intervention for alleviating portal pressure in patients with hepatitis cirrhosis.However,the current prognostic indicators for predicting long-term overall survival...BACKGROUND Splenectomy is an effective yet invasive intervention for alleviating portal pressure in patients with hepatitis cirrhosis.However,the current prognostic indicators for predicting long-term overall survival of these patients have several limitations.AIM To assess the potential of preoperative total bilirubin-albumin(B/A)ratio as a prognostic indicator for patients with hepatitis cirrhosis undergoing splenectomy.METHODS A total of 257 patients diagnosed with hepatitis cirrhosis were retrospectively enrolled in the study.Normality test,t-test,Wilcoxon test,χ2 test,or Fisher’s exact test was employed to analyze the intraoperative and postoperative conditions of the patients.Receiver operating characteristic(ROC)curve analysis was utilized to depict the 10-year overall survival rate.RESULTS During the follow-up period,85.99%of the patients survived,with a median survival time of 64.6 months.Multivariate analysis revealed that total serum B/A ratio was an independent risk factor for overall survival(P=0.037).ROC curve analysis demonstrated that a B/A ratio of 0.87 was the optimal cut-off value.Consequently,the patients were categorized into two groups:High B/A group(n=64)and low B/A group(n=193).The median follow-up time for the high B/A group and low B/A group was 56.8 months and 67.2 months,respectively(P=0.045).Notably,the high B/A group exhibited a significantly lower 10-year overall survival compared to the low B/A group(P<0.001).Patients with hepatocellular carcinoma(HCC)had lower overall survival rates.Patients with a high B/A ratio exhibited a lower overall survival than those with a low B/A rate in the overall cohort and the subgroups of patients with HCC or not,early Child-Pugh grade,low albumin-bilirubin grade,and model for end-stage liver disease score≥10(log-rank test,P<0.001 for all).CONCLUSION The B/A ratio can serve as an effective prognostic indicator for overall survival in patients with hepatitis B virusrelated cirrhosis following splenectomy,and a higher B/A ratio may suggest a poorer prognosis.展开更多
基金Supported by Projects of Anhui Provincial Health Commission,No.AHWJ2023A30146Scientific Research Projects in Anhui Provincial Colleges and Universities,No.2024AH050959the Anhui Provincial Natural Science Foundation,No.2408085MH222.
摘要BACKGROUND Clinically relevant postoperative pancreatic fistula(CR-POPF)is a critical complication of splenectomy,particularly in patients with cirrhosis,splenomegaly,and hypersplenism.However,there is a lack of comprehensive risk assessment models.AIM To identify independent risk factors for CR-POPF after splenectomy in this cohort and to develop a clinically useful predictive nomogram.METHODS This retrospective study included 186 patients who underwent splenectomy for cirrhotic splenomegaly with hypersplenism at our institution,between January 2019 and December 2024.PF was diagnosed and graded according to the 2016 International Study Group on Pancreatic Fistulas criteria.Univariate and multivariate least absolute shrinkage and selection operator-penalized logistic regression analyses were performed to identify independent risk factors.A receiver operating characteristic curve,calibration curves,and decision curve analysis.RESULTS Of the 186 patients,21 developed biochemical leak,and 6 developed CR-POPF,including 4 grade B and 2 grade C.Multivariate least absolute shrinkage and selection operator-penalized logistic analysis revealed that body mass index(BMI)[odds ratio=3.578,95%confidence interval(CI):1.156-11.080;P=0.027]and splenic thickness(odds ratio=1.250;95%CI:1.014-1.542;P=0.037)were independent risk factors for CR-POPF.The nomogram integrating these factors demonstrated excellent discriminative ability(area under the receiver operating characteristic curve=0.816,95%CI:0.500-0.993),good calibration(Hosmer-Lemeshow statistic=0.027,degrees of freedom=3,P=0.999>0.05),and favorable clinical utility(positive net benefit across a threshold probability range of approximately 0%to 99%in the decision curve analysis).PF grade analysis showed significant differences in BMI and pancreatic texture(P<0.05).CONCLUSION This study identified BMI and splenic thickness as independent risk factors for CR-POPF after splenectomy in patients with cirrhosis with splenomegaly.The developed nomogram provides a reliable tool for individualized risk prediction,facilitating targeted perioperative management to reduce CR-POPF incidence and improve patient outcomes.
摘要Gilbert综合征(Gilbert syndrome,GS)是因尿苷二磷酸葡萄糖醛酸转移酶1家族成员A1(UDPglucuronosyltransferase family 1 member A1,UGT1A1)基因突变导致尿苷二磷酸葡萄糖醛酸转移酶(uridine diphosphate glucuronosyltransferase,UGT酶)活性降低、以慢性非结合性高胆红素血症为特征的遗传性疾病,患者典型临床表现为间歇性黄疸,转氨酶正常,确诊依赖UGT1A1基因检测[1-2]。遗传性球形红细胞增多症(hereditary spherocytosis,HS)是红细胞膜蛋白基因突变导致红细胞球形化并在脾脏破坏增加,进而引发的溶血性疾病,患者典型表现为贫血、黄疸和脾大,可有外周血球形红细胞增多、渗透脆性增加,基因检测可明确ANK1、SPTA1等突变[3]。两病共患时可因临床表现重叠发生误诊或漏诊。现对我单位收治的1例GS共患HS行腹腔镜下脾切除的患者诊治经过总结报道如下。
基金Supported by 2024 Fuyang Key Research and Development Program,Special Project for Clinical Medicine Research and Transformation,No.FK20245501.
摘要BACKGROUND Traumatic splenic rupture is the most common solid organ injury in blunt abdominal trauma,and splenectomy remains a critical intervention for patients with hemodynamic instability.The shock index(SI),a simple hemodynamic indicator,has demonstrated significant value in prognostic assessment of trauma patients.However,studies on the predictive value of SI in patients undergoing splenectomy for traumatic splenic rupture are relatively limited.AIM To investigate the predictive value of preoperative SI on postoperative complications,mortality,and long-term survival in patients with traumatic splenic rupture undergoing splenectomy,and to construct a prognostic prediction model based on SI.METHODS Clinical data of 212 patients with traumatic splenic rupture who underwent splenectomy from January 2020 to January 2025 were retrospectively analyzed.Patients were divided into low SI group(SI<0.9,n=78),moderate SI group(0.9≤SI<1.3,n=89),and high SI group(SI≥1.3,n=45)based on preoperative SI(SI=heart rate/systolic blood pressure).Basic information,clinical indicators at admission,laboratory tests,imaging examinations,surgery-related indicators,and prognostic data were collected.The Clavien-Dindo grading system was used to assess postoperative complications.Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for severe postoperative complications.A prognostic prediction model was constructed and its discriminative ability was evaluated using receiver operating characteristic curves.Kaplan-Meier method and Cox regression model were used for survival analysis.RESULTS With increasing SI,patients showed significantly decreased blood pressure,significantly increased heart rate and respiratory rate,more severe splenic injury,and significantly increased intraoperative blood loss and transfusion volume(all P<0.001).The incidence of severe postoperative complications in the high SI group(26.7%)was significantly higher than that in the moderate SI group(12.4%)and low SI group(3.8%)(P<0.001).Multivariate logistic regression analysis showed that SI[odds ratio(OR)=2.34,95%confidence interval(CI):1.25-4.38,P=0.008],splenic injury grade≥IV(OR=2.97,95%CI:1.28-6.86,P=0.011),hemoglobin≤90 g/L(OR=3.14,95%CI:1.40-7.07,P=0.005),lactate level≥4.0 mmol/L(OR=3.97,95%CI:1.76-8.92,P=0.001),and massive intraperitoneal hemorrhage(OR=2.43,95%CI:1.02-5.78,P=0.045)were independent risk factors for severe postoperative complications.The multivariate prediction model based on SI had an area under the curve of 0.847(95%CI:0.789-0.905)for predicting severe postoperative complications,which was significantly superior to SI alone(area under the curve=0.782,P=0.033).The optimal cutoff value of SI for predicting severe postoperative complications was 1.15,with sensitivity of 76.9%and specificity of 81.2%.Survival analysis showed that 1-year survival rates in the low,moderate,and high SI groups were 98.7%,96.6%,and 86.7%,respectively(P=0.015).Cox regression analysis confirmed that SI was an independent risk factor affecting patient survival(hazard ratio=1.85,95%CI:1.16-2.95,P=0.010).CONCLUSION Preoperative SI is an important predictor of prognosis in patients with traumatic splenic rupture undergoing splenectomy,which can effectively identify high-risk patients and guide clinical decision-making.
摘要BACKGROUND Splenectomy is an effective yet invasive intervention for alleviating portal pressure in patients with hepatitis cirrhosis.However,the current prognostic indicators for predicting long-term overall survival of these patients have several limitations.AIM To assess the potential of preoperative total bilirubin-albumin(B/A)ratio as a prognostic indicator for patients with hepatitis cirrhosis undergoing splenectomy.METHODS A total of 257 patients diagnosed with hepatitis cirrhosis were retrospectively enrolled in the study.Normality test,t-test,Wilcoxon test,χ2 test,or Fisher’s exact test was employed to analyze the intraoperative and postoperative conditions of the patients.Receiver operating characteristic(ROC)curve analysis was utilized to depict the 10-year overall survival rate.RESULTS During the follow-up period,85.99%of the patients survived,with a median survival time of 64.6 months.Multivariate analysis revealed that total serum B/A ratio was an independent risk factor for overall survival(P=0.037).ROC curve analysis demonstrated that a B/A ratio of 0.87 was the optimal cut-off value.Consequently,the patients were categorized into two groups:High B/A group(n=64)and low B/A group(n=193).The median follow-up time for the high B/A group and low B/A group was 56.8 months and 67.2 months,respectively(P=0.045).Notably,the high B/A group exhibited a significantly lower 10-year overall survival compared to the low B/A group(P<0.001).Patients with hepatocellular carcinoma(HCC)had lower overall survival rates.Patients with a high B/A ratio exhibited a lower overall survival than those with a low B/A rate in the overall cohort and the subgroups of patients with HCC or not,early Child-Pugh grade,low albumin-bilirubin grade,and model for end-stage liver disease score≥10(log-rank test,P<0.001 for all).CONCLUSION The B/A ratio can serve as an effective prognostic indicator for overall survival in patients with hepatitis B virusrelated cirrhosis following splenectomy,and a higher B/A ratio may suggest a poorer prognosis.