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Zinc-air battery-H2O2generation system:Current progress,key challenges,optimization strategies and future developments 认领 引用
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作者 Junjie Wang Shulin Gao Sujuan Hu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期216-230,共15页
The zinc-air battery(ZAB)-hydrogen peroxide(H2O2)generation system produces H2O2through a 2-electron oxygen reduction reaction(ORR)at the ZAB air cathode while simultaneously providing external electrical ... The zinc-air battery(ZAB)-hydrogen peroxide(H2O2)generation system produces H2O2through a 2-electron oxygen reduction reaction(ORR)at the ZAB air cathode while simultaneously providing external electrical power.This system offers a promising,eco-friendly solution for both energy storage and chemical production.Despite its promise,a comprehensive review of this topic is still scarce.To fill this void,this review discusses the background and mechanisms of the ZAB-H2O2generation system and covers approaches to achieving efficient and stable operation through 2e⁻ORR catalyst design and optimization,the regulation of the electrolyte,cathode configuration design,and electrochemical operating conditions.From the perspective of the cathode,anode,electrolyte,and their integration with energy systems,this review systematically analyzes the key challenges and optimization strategies.In addition,this review summarizes the main technical bottlenecks this system faces and proposes potential solutions and development suggestions for future research and practical applications. 展开更多
关键词 Zinc-air battery H2O2 2e-ORR Electrochemical catalysts Application
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Revealing low-temperature reaction mechanism of cobalt-doped CeO2 catalyst for catalytic removal of methyl mercaptan 认领 引用
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作者 Zijun Huang Xiaohua Cao +5 位作者 Huaiyu Xu Miao Lin Dedong He Dingkai Chen Jichang Lu Yongming Luo 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第3期811-821,I0003,共11页
Methyl mercaptan(CH3SH)is notorious for global air pollution owing to its odorous characteristics and adverse health effects.Although CeO2 is currently regarded as a promising catalyst for CH3SH decomposition... Methyl mercaptan(CH3SH)is notorious for global air pollution owing to its odorous characteristics and adverse health effects.Although CeO2 is currently regarded as a promising catalyst for CH3SH decomposition,the high conversion temperature followed by high energy consumption is still a bottleneck.Herein,the cobalt-doped CeO2 catalyst was synthesized by a facile one-pot preparation strategy and successfully reduces the decomposition temperature from 450 to 250℃.Further studies demonstrate that the excellent low-temperature catalytic activity of Co0.6Ce0.4O2-σis attributed to its abundant oxygen vacancies and reactive oxygen species.Oxygen vacancies promote the adsorption and dissociation of CH3SH,while reactive oxygen species facilitate the decomposition of CH3SH.Moreover,Co acts as a sacrificial agent for the adsorption of sulfur species in CH3SH,while Ce is responsible for the adsorption and activation of CH3SH as the active metal phase.Furthermore,the migration and transformation mechanism of CH3SH on the surface of Co0.6Ce0.4O2-δwas determined via in situ diffuse reflectance infrared Fourier transform spectra(in situ-DRIFTS).This work provides a new strategy to synthesize highperformance catalysts for decomposing sulfur-containing volatile organic compounds(VOCs)at low temperatures,which is beneficial to decreasing the energy consumption. 展开更多
关键词 CoxCeyO2-δ Methyl mercaptan Catalytic decomposition Oxygen vacancies Reaction mechanism Rare earths
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A smartphone sensing platform based on cucurbit[8]uril for rapid visual quantitative detection of S2O82- 认领 引用
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作者 Shang-Wei Yuan Li Zeng +5 位作者 Li Wu Ji-Li Yuan Chao Kang Xi Zeng Pei-Hua Ma Xin Xiao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期388-393,共6页
In this paper,a novel multicolor-responsive fluorescent probe for the rapid and sensitive detection of persulfate ions(S2O82-),KT@Q[8],is constructed via host-guest interactions between cucurbit[8]uril(Q[8])a... In this paper,a novel multicolor-responsive fluorescent probe for the rapid and sensitive detection of persulfate ions(S2O82-),KT@Q[8],is constructed via host-guest interactions between cucurbit[8]uril(Q[8])and 3,6-bis[4-(4-bromophenyl)pyridinium]-carbazole dichloride(KT).Upon interaction with S2O82-,the KT@Q[8]probe exhibits a fluorescence emission blue shift concurrent with a fluorescence color transition gradually from yellow to green.Notably,the probe demonstrates high selectivity for S2O82-even in the presence of competing anions and sulphur-containing metal salts,achieving a detection limit of 0.38μmol/L.When integrated with smartphone-based RGB analysis,this probe enables rapid visual quantification of S2O82-without requiring sophisticated instrumentation,and can be effectively used to detect S2O82-in tap water,lake water,honey,and white wine.Furthermore,machine learning algorithms enhanced predictive accuracy during data analysis.Overall,this work not only advances a practical approach for persulfate monitoring but also expands the application range of cucurbituril-based fluorescence supramolecular assemblies. 展开更多
关键词 uril KT S2O82- Fluorescent probe Supramolecular self-assembly
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等离子喷涂Al2O3-40%TiO2强化聚四氟乙烯不粘涂层的制备及其性能研究 认领 引用
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作者 曹达华 高岩 +4 位作者 雒晓涛 申继豪 程志喜 万鹏 李洪伟 《表面技术》 EI CAS CSCD 北大核心 2026年第3期252-261,共10页
目的针对传统不粘涂层耐磨性差、表面磨损后疏水性快速衰减等问题,提出一种离散Al2O3-40%TiO2(AT40)陶瓷凸起结构强化的聚四氟乙烯(PTFE)耐磨不粘涂层结构设计,在摩擦磨损中,通过高硬度的陶瓷凸起对摩擦副的支撑作用,避免PTFE... 目的针对传统不粘涂层耐磨性差、表面磨损后疏水性快速衰减等问题,提出一种离散Al2O3-40%TiO2(AT40)陶瓷凸起结构强化的聚四氟乙烯(PTFE)耐磨不粘涂层结构设计,在摩擦磨损中,通过高硬度的陶瓷凸起对摩擦副的支撑作用,避免PTFE被快速磨除,以提高不粘涂层的耐磨性。方法首先,采用等离子喷涂半熔化粒子沉积具有高表面粗糙度的AT40陶瓷涂层;其次,采用PTFE填充AT40陶瓷涂层表面半熔化粒子凸起间的空隙,获得复合涂层。研究喷涂距离对AT40涂层表面结构的影响,揭示AT40涂层表面粗糙度对复合涂层耐磨性能及持久不粘性能的影响规律。结果当喷涂距离从40mm分别提高到80、120、150mm时,等离子喷涂AT40陶瓷涂层的表面粗糙度先减小后增加,在喷涂距离为40mm时,粗糙度Ra最高,为19.3μm,Rz为220.4μm。将该条件下制备的AT40陶瓷涂层表面涂覆PTFE面层后,在摩擦磨损25000周后依然能够保持不粘性能,相较于传统的PTFE不粘涂层提升了约4倍。结论大气等离子喷涂的高粗糙度AT40陶瓷底层与PTFE面层的复合耐磨不粘涂层具有优异的耐磨性能和持久的不粘性能,可大幅提升不粘烹饪器皿的使用寿命。 展开更多
关键词 等离子喷涂 Al2O3-40%TiO2/PTFE复合涂层 表面微凸结构 耐磨性 疏水性
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Carbon nitride-based single-molecular Van der Waals heterojunction for selective photocatalytic CO2reduction to CO 认领 引用
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作者 Hongjun Dong Chunhong Qu +5 位作者 Jiaming Li Deping Wang Min Zhang Zuoyi Liu Liqiu Zhang Chunmei Li 《Green Energy & Environment》 SCIE EI CAS CSCD 2026年第3期774-783,共10页
Single-molecular heterojunctions have demonstrated significant application potential in the fields of photocatalysis due to prominent photoelectric properties,while the charge transfer behavior still needs to be furth... Single-molecular heterojunctions have demonstrated significant application potential in the fields of photocatalysis due to prominent photoelectric properties,while the charge transfer behavior still needs to be further discussed.In this work,a fresh single-molecular Van der Waals heterojunction is fabricated through self-assembly of dibromo(1,10-phenanthroline-κN1,κN10)nickel(NiphenBr)molecules on the surface PCN nanosheets,which dramatically boosts the performance of selective photocatalytic CO2reduction to CO.This unique assembled architecture effectively regulates electronic band structure and promotes the interfacial transfer and separation of photogenerated carriers owing to theπ-πcoupling effect between NiphenBr and PCN.Meanwhile,the single-molecular dispersed NiphenBr molecules also prevent their aggregation on PCN under the strongπ-πinteraction,and further provide abundant single-atom active sites for CO2reduction reaction.Therefore,the average rate of photocatalytic reduction of CO2to CO for the optimal NiphenBr/PCN-1 sample reaches 5.46 and 2.73 times that of PCN and NiphenBr,respectively.This work opens a new avenue for the single-molecular heterojunction in the application of photocatalytic reactions. 展开更多
关键词 NiphenBr/PCN Single-molecular VdWs heterojunction Photocatalytic CO2reduction π-πinteraction
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Enriched NKX2-1 Mutations in Bronchiolar Adenoma Variants:Evidence for Malignant Transformation or an Indolent Entity 认领 引用
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作者 Lu-yao Li Gong-ming Dong +4 位作者 Yi-xin Ma Jie Liu Yan Shi Fu-quan Jia Guan-jun Zhang 《Current Medical Science》 SCIE CAS CSCD 2026年第1期116-130,共15页
Objective Bronchiolar adenoma(BA)is a peripheral pulmonary neoplasm characterized by a bilayered cell structure com-posed of basal cells and luminal cells.Owing to its low incidence and limited research data,clinician... Objective Bronchiolar adenoma(BA)is a peripheral pulmonary neoplasm characterized by a bilayered cell structure com-posed of basal cells and luminal cells.Owing to its low incidence and limited research data,clinicians and pathologists still have an insufficient understanding of this disease.This study aims to characterize the morphological,immunohistochemical,and genetic features of BA and its variants,and to determine whether BA can progress to a malignancy.Methods Among these 33 cases,21 were histologically characterized by double-layered tumors with continuous basal cell layers.Six patients exhibited a partial classic bilayer,transitioning from a bilayer to a monolayer in certain lesion areas(mixed-type BAs).Six other BA-like tumors with monolayered components might represent the early stage of malignant transformation of BA.Next-generation sequencing analysis was conducted on 33 cases to elucidate the genetic spectrum.Results All the cellular components exhibited a relatively mild morphology.Immunohistochemical analysis revealed that basal cells coexpressed p40 and cytokeratin 5/6.Thyroid transcription factor 1 was expressed in the double-cell layer,which consists of ciliated columnar epithelial cells,basal cells,nonciliated columnar epithelial cells,and cuboidal epithelial cells.The pan-cancer gene panel was used to observe driver alterations in 9 of 21 classic bilayered BAs(43%),2 of 6 mixed-type BAs(33%),and 3 of 6 monolayered BA-like lesions(50%).Genetically,monolayered BA-like lesions shared some alterations with classic BAs in mutational signatures,whereas NKX2-1 mutations were enriched only in monolayered BA-like lesions.Conclusion These findings underscore the histopathological and genetic characteristics of BA and its variants,suggesting that monolayered BA-like lesions have the potential to develop into lung adenocarcinoma.In the future,more cases should be recruited to further explore the malignant transformation of this specific entity via the multidimensional spectrum. 展开更多
关键词 Bronchiolar adenoma Monolayered BA-like lesions Histopathology Genomic analysis NKX2-1 mutation Lung adenocarcinoma Next-generation sequencing TTF-1
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Sustainable tailings utilization:Selective flotation of microfine ilmenite with 2-(hydroxycarbamoyl)decanoic acid 认领 引用
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作者 Yamin Kang Yide Xu +6 位作者 Hongbin Wang Peng Li Fanfan Zhang Xiaokui Che Guosheng Li Yijun Cao Guixia Fan 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2026年第8期1719-1731,共13页
The microfine ilmenite generated during ilmenite beneficiation is challenging to separate from gangue.As a result,it is often discarded directly into tailings,causing wastage of titanium resources.In this study,2-(hyd... The microfine ilmenite generated during ilmenite beneficiation is challenging to separate from gangue.As a result,it is often discarded directly into tailings,causing wastage of titanium resources.In this study,2-(hydroxycarbamoyl)decanoic acid(CBHA),a bifunctional collector with strong selectivity and high collecting capacity,was synthesized for the recovery of microfine ilmenite from tailings.When CBHA was used at a low dosage of 800 g,the concentrate with a grade of 47.70%and a recovery of 65.74%was achieved.Moreover,the adsorption mechanism was revealed by quartz crystal microbalance with dissipation monitoring(QCM-D),atomic force microscopy(AFM),and density functional theory(DFT).The results showed that the adsorption amount of CBHA on the ilmenite surface reached 510.27 ng/cm2and the maximum adhesion force between ilmenite particles reached 22.62 nN,which were more than those on the forsterite surface.This is because the oxygen atoms of CBHA contributed electrons to match with three Ti or Fe sites on the ilmenite surface,resulting in a bicyclic adsorption configuration with an inner ternary ring and an outer polycyclic.In contrast,CBHA adsorbed on the forsterite surface via a single bond or monocyclic structure.In summary,this method promotes sustainable utilization of ilmenite and achieves economic benefits. 展开更多
关键词 Microfine ilmenite 2-(hydroxycarbamoyl)decanoic acid Bicyclic adsorptionstructure Selectivity flotation Sustainable tailingsutilization
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Synergetic photocatalytic H2 evolution and H2S conversion over S-scheme Co3(PO4)2/CoSx/twinned-Cd0.5Zn0.5S 认领 引用
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作者 Xinyi Ma Ziyi Xiao +3 位作者 Xueqing Hu Haobin Hu Wenhua Xue Enzhou Liu 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第1期146-158,共13页
Developing sustainable,low-cost H2S conversion technologies holds significant importance for the coal chemical and petrochemical industries.Herein,twinned Cd0.5Zn0.5S(T-CZS)homojunctions serve as model photoc... Developing sustainable,low-cost H2S conversion technologies holds significant importance for the coal chemical and petrochemical industries.Herein,twinned Cd0.5Zn0.5S(T-CZS)homojunctions serve as model photocatalysts,with a Na2S/NaH2PO2 solution simulating H2S absorption to regulate S2-/HS-transformation pathways for concurrent efficient H2 evolution and desulfurization.Notably,at 3 mol·L-1 NaH2PO2 concentration,the H2 evolution rate(r H2)over T-CZS reaches 233.9 mmol·g-1·h-1—representing a 5.5-fold enhancement versus 0.1 mol·L-1 Na2S alone.Mechanistic studies reveal that the two-step oxidation of H2PO2-delivers four electrons for H+reduction while simultaneously scavenging deleterious S22-species.This dual function mitigates light-absorption competition,enhances interfacial electron density,and accelerates H2-evolution kinetics.Further,Co3(PO4)2/CoS x loading boosts H2 production to 292.1 mmol·g-1·h-1,primarily ascribed to suppressed bulk/interface charge recombination.Crucially,acidification of post-reaction solutions yields pure elemental sulfur(S)as a yellow solid.Practical viability was validated using H2S preparation and absorption system,confirming robust catalyst performance and system efficacy for integrated high-efficiency H2 production and S recovery.The critical role and significant potential of H2PO2-in enhancing H2 evolution in S2-/HS-solutions were emphasized,offering potential strategies for efficient photocatalytic conversion of S2-/HS-.This work establishes a new paradigm for green,economical H2S valorization. 展开更多
关键词 Photocatalyst Desulfurization Conversion of S 2-/HS- Twinned-Cd0.5Zn0.5S Homo-heterojunction
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Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway 认领 引用
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作者 Yiming Huo Bing Xiao +8 位作者 Haojie Yu Yang Xu Jiachen Zheng Chao Huang Ling Wang Haiyan Lin Jiajun Xu Pengfei Yang Fang Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2060-2072,共13页
Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration vi... Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling;however,their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection,which are similar to the risks associated with other stem cell transplantations.The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells,which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.In vitro,small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation,migration,tube formation,and barrier function of perineurial cells,and subsequently upregulated the expression of tight junction proteins.Furthermore,in a rat model of sciatic nerve defects bridged with silicon tubes,treatment with small extracellular vesicles derived from hair follicle neural crest stem cells resulted in higher tight junction protein expression in perineurial cells,thus facilitating neural tissue regeneration.At 10 weeks post-surgery,rats treated with small extracellular vesicles derived from hair follicle neural crest stem cells exhibited improved nerve function recovery and reduced muscle atrophy.Transcriptomic and micro RNA analyses revealed that small extracellular vesicles derived from hair follicle neural crest stem cells deliver mi R-21-5p,which inhibits mothers against decapentaplegic homolog 7 expression,thereby activating the transforming growth factor-β/mothers against decapentaplegic homolog signaling pathway and upregulating hyaluronan synthase 2 expression,and further enhancing tight junction protein expression.Together,our findings indicate that small extracellular vesicles derived from hair follicle neural crest stem cells promote the proliferation,migration,and tight junction protein formation of perineurial cells.These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells,and present a novel approach for the clinical treatment of peripheral nerve defects. 展开更多
关键词 hair follicle neural crest stem cells HAS2 migration miR-21-5p perineurial cells proliferation peripheral nerve injury Smad7 small extracellular vesicles transforming growth factor-β/SMAD signaling pathway
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A Eu-based metal-organic framework fluorescent film:Preparation and sensing of Cr2O72- and tryptamine 认领 引用
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作者 JIAO Xinyi ZHANG Xin +5 位作者 BAI Wanqiao SUN Xuehua CUI Huali REN Yixia CHAI Hongmei GAO Loujun 《无机化学学报》 SCIE CAS CSCD 北大核心 2026年第5期1113-1120,共8页
To address the challenges of poor solubility and difficult recyclability of powdered metal-organic frameworks(MOFs),a Eu-based MOF complex,[EuNa(L)(H2O)3]·2H2O(Eu/Na-MOF),was synthesized by the hydrother... To address the challenges of poor solubility and difficult recyclability of powdered metal-organic frameworks(MOFs),a Eu-based MOF complex,[EuNa(L)(H2O)3]·2H2O(Eu/Na-MOF),was synthesized by the hydrothermal method using 3,5-bis(3,5-dicarboxyphenyl)-1H-1,2,4-triazole(H4L)as the ligand in this study.Systematic characterization and performance evaluation revealed that the complex exhibits a unique 3D structure,high phase purity,excellent thermal stability,and outstanding luminescent properties.Furthermore,the complex was encapsulated in poly(methyl methacrylate)(PMMA)to fabricate a flexible and water-washable composite fluorescent film(Eu/NaMOF/PMMA).Based on static and dynamic quenching mechanisms,respectively,the film enables reversible detection of tryptamine and Cr2O72- ions in aqueous solutions,demonstrating high selectivity,stability,and portability. 展开更多
关键词 metal-organic framework Eu/Na-MOF fluorescent film sensor tryptamine Cr2O72-
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Pd/TiO2催化环戊酮一步合成2-环戊基环戊酮反应性能 认领 引用
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作者 程斌 张蕊 +2 位作者 李丹辉 赵丽丽 安华良 《石油学报（石油加工）》 EI CAS CSCD 北大核心 2026年第4期1080-1092,共13页
采用过量浸渍法制备Pd/TiO2催化剂,该催化剂对环戊酮一步合成2-环戊基环戊酮具有较好的催化性能。采用NH3-TPD和CO2-TPD等手段对催化剂进行表征,考察了制备和反应条件对催化剂性能的影响。结果表明:酸量影响催化剂的活性并且有利... 采用过量浸渍法制备Pd/TiO2催化剂,该催化剂对环戊酮一步合成2-环戊基环戊酮具有较好的催化性能。采用NH3-TPD和CO2-TPD等手段对催化剂进行表征,考察了制备和反应条件对催化剂性能的影响。结果表明:酸量影响催化剂的活性并且有利于C=O键加氢,碱量影响缩合产物的总生成速率;在适宜的催化剂制备条件和反应条件(反应温度210℃、氢气压力3 MPa、反应时间6 h)下,环戊酮转化率为83.1%,2-环戊基环戊酮选择性为88.0%。使用后的催化剂(Pd/TiO2-U)经焙烧和还原,催化剂上高度分散的金属Pd原子容易发生迁移,形成纳米粒子,从而降低催化剂的催化活性。为解决催化剂失活问题,采用溶剂洗涤方法对Pd/TiO2-U催化剂进行再生处理。其中,Pd/TiO2-U催化剂经二氯甲烷洗涤处理后,再循环使用4次,催化性能仍基本不变。动力学研究表明,2-环戊烯基环戊酮加氢反应的活化能低于环戊酮自缩合合成2-环戊烯基环戊酮反应的活化能。 展开更多
关键词 Pd/TiO2 环戊酮 2-环戊基环戊酮 动力学 一步合成
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封孔处理对亚音速等离子喷涂纳米Al2O3-13TiO2涂层耐腐蚀性能的影响 认领 引用
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作者 殷硕 王泽 +1 位作者 程江波 洪晟 《中国表面工程》 EI CAS CSCD 北大核心 2026年第1期155-165,共11页
等离子喷涂Al2O3-13TiO2涂层具有优异的耐磨性和良好的耐腐蚀性,为满足海洋装备对其长效防护的迫切需求,亟须解决Al2O3-13TiO2涂层高孔隙率的问题。采用亚音速等离子喷涂(SPS)技术制备纳米结构Al2O3-13TiO2... 等离子喷涂Al2O3-13TiO2涂层具有优异的耐磨性和良好的耐腐蚀性,为满足海洋装备对其长效防护的迫切需求,亟须解决Al2O3-13TiO2涂层高孔隙率的问题。采用亚音速等离子喷涂(SPS)技术制备纳米结构Al2O3-13TiO2涂层,随后基于常压浸渍封孔和真空浸渍封孔方法,分别利用有机硅树脂和无机磷酸铝封孔剂对其进行封孔处理。通过X射线衍射仪、扫描电子显微镜、电化学工作站等研究封孔处理工艺对涂层组织结构和耐腐蚀性能的影响。结果表明,相较于常压浸渍封孔方法,真空浸渍封孔方法能更高效地填充涂层中的微裂纹和孔隙;有机硅树脂比无机磷酸铝的封孔效果更好,这是因为干燥过程中磷酸铝胶体中的水分蒸发产生了内应力,进而导致新的微裂纹产生。在四种封孔工艺中,经过真空浸渍有机硅树脂封孔的涂层具有最大的电荷转移电阻(Rct)、极化电阻(Rp)、容抗弧半径和阻抗模值,显示出最佳的耐腐蚀性能。通过不同封孔工艺的处理,有效调控了SPS纳米结构Al2O3-13TiO2涂层的组织结构与耐腐蚀性能,可为后续海洋装备的腐蚀防护研究提供新思路。 展开更多
关键词 纳米Al2O3-13TiO2涂层 亚音速等离子喷涂 封孔处理 电化学腐蚀
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Clinical analysis of anxiolytic molecular targets of Kalanchoe pinnata to stimulate gut skin brain axis through COX-2(PTGS2)pathway modulation 认领 引用
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作者 Arockiya Anita Margret Priyadharshini Chandrasekaran +2 位作者 Arockiaraj Sherlin Rosita Prakash Piruthiviraj Gayathri Rengasamy 《Medical Data Mining》 CAS 2026年第3期15-27,共13页
Background:Kalanchoe pinnata,commonly known as“air plant”or“miracle leaf,”has been widely used in traditional medicine for its analgesic,wound-healing,anti-stress,and dermatological properties.Chronic stress can d... Background:Kalanchoe pinnata,commonly known as“air plant”or“miracle leaf,”has been widely used in traditional medicine for its analgesic,wound-healing,anti-stress,and dermatological properties.Chronic stress can disrupt the gut microbiome,leading to both physical and mental health issues.Notably,the interplay between inflammatory skin diseases and anxiety is known to cause dysbiosis in gut microbiota.Given the gut-skin axis,the present study explores the prebiotic potential of K.pinnata phytocompounds in promoting anxiolytic effects and skin restoration through modulation of the gut microbiota.Methods:In vivo behavioural assays and histopathological evaluations were performed to assess the physiological effects of K.pinnata.GC-MS analysis identified key phytocompounds,which were further subjected to in silico studies.Network pharmacology analyses,including KEGG pathway mapping,gene ontology,and protein-protein interaction analysis,were conducted to determine gene targets associated with inflammatory skin disease,anxiety disorders,and inflammatory bowel diseases.Molecular docking studies were performed to validate the interactions between bioactive compounds and the identified hub genes.Results:Behavioural and histopathological studies revealed significant restorative effects of K.pinnata on both gut and skin tissues.Capillary microclots and aggregation were notably reduced.Two key bioactive compounds—4-(Benzoyl methyl)-6-Methyl-2H-1,4-Benzoxazin-3-One and 2-Fluoro-5-Trifluoromethyl Benzoic Acid,Pentyl Ester—demonstrated intense interaction with 10 hub genes(PTGS2,EGFR,MAPK3,SRC,NFKB1,CCND1,JAK2,ICAM1,HSP90AA1,and MMP9).Docking analysis revealed a strong binding affinity of 4-(Benzoyl methyl)-6-methyl-2H-1,4-benzoxazin-3-one with PTGS2(binding energy:−9.83 kcal/mol),suggesting a potential mechanism for modulating COX-2-mediated inflammatory responses.Conclusion:The study endorses the therapeutic potential of K.pinnata in modulating the gut-brain-skin axis through its prebiotic and anti-inflammatory activities.Specifically,it highlights the ability of its bioactive compounds to target PTGS2,a key enzyme in inflammation,supporting its application in treating anxiety,skin inflammation,and gut dysbiosis-related disorders. 展开更多
关键词 Kalanchoe pinnata gut-brain skin axis network pharmacology 4-(Benzoylmethyl)-6-Methyl-2h-1,4-Benzoxazin-3 COX-2(PTGS2)
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NH2-MIL-125/TiO2催化剂的制备及光催化脱硝性能研究 认领 引用
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作者 张旭媛 李晓雪 +1 位作者 张晓 王淑勤 《现代化工》 CAS CSCD 北大核心 2026年第8期206-215,共10页
采用微波-水热法制备NH2-MIL-125/TiO2(NM/T)复合催化剂,利用X射线衍射(XRD)、X射线光电子能谱(XPS)等表征手段,以NO为目标污染物,探究不同条件下NM/T对NO去除率的影响。结果表明,在可见光下NM/T去除率可达89.5%,是纯TiO2材料... 采用微波-水热法制备NH2-MIL-125/TiO2(NM/T)复合催化剂,利用X射线衍射(XRD)、X射线光电子能谱(XPS)等表征手段,以NO为目标污染物,探究不同条件下NM/T对NO去除率的影响。结果表明,在可见光下NM/T去除率可达89.5%,是纯TiO2材料的1.85倍,且连续使用5次后去除率仍然在65%以上;进一步探究发现,烟气湿度不会使去除率显著下降;在CO2、SO2等干扰气体共存时,去除率仍在70%以上。表征结果显示,复合后比表面积增大,禁带宽度降低,有利于推动反应进行。自由基捕获实验也表明在光催化反应进程中,·OH起主导作用,是反应的主要活性物质。 展开更多
关键词 微波-水热法 NH2-MIL-125/TiO2 低温光催化 脱硝
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CuNP-TiO2-(OH)CNTs催化CO2电合成碳酸二甲酯 认领 引用
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作者 王有佳 王文超 +5 位作者 安星宇 马欣 田博琛 田玉心 刘艳升 侯军伟 《石油与天然气化工》 CAS CSCD 北大核心 2026年第3期37-51,共15页
目的锐钛矿TiO2虽以储量丰富、缺陷结构可调著称,但传统观点认为其导电性差、多碳产物选择性低,难以用于CO2电催化合成多碳产物。据此,本研究旨在提出晶格调控-界面电子耦合-碳管协同策略,成功将TiO2重构为高效催化CO2电合... 目的锐钛矿TiO2虽以储量丰富、缺陷结构可调著称,但传统观点认为其导电性差、多碳产物选择性低,难以用于CO2电催化合成多碳产物。据此,本研究旨在提出晶格调控-界面电子耦合-碳管协同策略,成功将TiO2重构为高效催化CO2电合成碳酸二甲酯的复合体系。方法通过500℃热处理精准调控TiO2的晶格结构与表面氧空位的相对含量,为铜纳米团簇提供锚定位点;引入羟基化碳纳米管[(OH)CNTs]构建三维导电与传质网络,协同优化电子传输与物质扩散;借助Cu-O-Ti界面配位诱导电子金属-载体相互作用(electronic metal-support interaction,EMSI),形成Cuδ+-OV-Ti3+电子协同位点。结果球差校正电镜、同步辐射X射线吸收近边结构/扩展边结构精细结构谱及密度泛函理论计算等表征证实:EMSI不仅将CO2还原关键中间体*COOH的生成能垒从2.36 eV降至2.05 eV,还适度弱化了甲醇活化中间体*OCH3的吸附强度(从0.71 eV降至0.52 eV),实现多步反应的精准时序匹配。电化学测试表明,在-2.4 V(相对于Ag/AgCl参比电极)最优条件下,DMC的法拉第效率达44.68%;经10 h长循环测试,性能保持率超95%,铜溶出量仅1.30%(质量分数)。结论本研究突破了TiO2基催化剂在合成多碳产物方面的传统认知局限,为设计廉价、高效的铜基催化剂及实现CO2的资源化转化提供了新思路。 展开更多
关键词 CO2电还原 碳酸二甲酯 TiO2晶格调控 铜团簇 电子金属-载体相互作用 羟基化碳纳米管
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太阳光/TiO2-γ-Al2O3/Fenton处理垃圾渗滤液的研究 认领 引用
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作者 阮峻杰 任梦娇 +1 位作者 葛根旺 蒋宝军 《辽宁化工》 CAS 2026年第1期69-73,共5页
为了优化垃圾渗滤液处理技术,采用TiO2-γ-Al2O3复合催化剂与太阳光/Fenton法相结合的技术处理垃圾渗滤液,考察了反应条件对COD去除率的影响,分析了投加TiO2-γ-Al2O3对太阳光/Fenton法有何作用,对比了太阳光/Fenton... 为了优化垃圾渗滤液处理技术,采用TiO2-γ-Al2O3复合催化剂与太阳光/Fenton法相结合的技术处理垃圾渗滤液,考察了反应条件对COD去除率的影响,分析了投加TiO2-γ-Al2O3对太阳光/Fenton法有何作用,对比了太阳光/Fenton、太阳光/TiO2-γ-Al2O3/Fenton、UV/TiO2/Fenton这3种工艺的处理效果。结果表明:在太阳光/TiO2-γ-Al2O3/Fenton法中,当催化剂与COD质量比为0.8、H2O2与Fe2+的摩尔比为5、H2O2与COD的质量比为2、pH为4、反应时间为30 min时,对渗滤液的处理效果最好,COD去除率达到92.68%,比太阳光/Fenton法的COD去除率提高了8.45%,比UV/TiO2/Fenton法的COD去除率提高3.76%。 展开更多
关键词 太阳光 TiO2-γ-Al2O3 Fenton 垃圾渗滤液
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龙葵通过Bcl-2/Bax/Caspase-3通路对四氯化碳诱导大鼠肝纤维化的治疗作用及机制 认领 引用 被引量：3
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作者 吴闵 安祯祥 +3 位作者 何远利 文维农 苏强 何松 《中国实验方剂学杂志》 CAS CSCD 北大核心 2026年第2期117-125,共9页
目的:探讨龙葵对四氯化碳(CCl4)所致大鼠肝纤维化模型的治疗效果及其潜在的分子机制。方法:将60只SD大鼠随机分为空白组,模型组,龙葵低、中、高剂量组(0.9、1.8、3.6 g·kg-1),水飞蓟宾胶囊组(18.9 mg·kg-1),除空白组外... 目的:探讨龙葵对四氯化碳(CCl4)所致大鼠肝纤维化模型的治疗效果及其潜在的分子机制。方法:将60只SD大鼠随机分为空白组,模型组,龙葵低、中、高剂量组(0.9、1.8、3.6 g·kg-1),水飞蓟宾胶囊组(18.9 mg·kg-1),除空白组外,均通过腹腔注射40%的CCl4溶液构建肝纤维化大鼠模型,灌胃治疗4周后腹腔麻醉后腹主动脉取血,处死大鼠,分离肝脏。通过苏木素-伊红(HE)染色、马松(Masson)染色观察大鼠病理改变;检测大鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)及肝纤维化指标III型前胶原(PCIII)、IV型胶原(ColIV)、层粘连蛋白(LN)、透明质酸(HA)的含量;实时荧光定量聚合酶链式反应(Real-time PCR)及蛋白免疫印迹法(Western blot)检测B细胞淋巴瘤-2/B细胞淋巴瘤-2相关X蛋白/胱天蛋白酶-3(Bcl-2/Bax/Caspase-3)信号通路相关信使核糖核酸(mRNA)及蛋白的表达。结果:病理结果显示,与空白组比较,模型组肝组织呈现明显肝细胞水肿、炎细胞浸润、结缔组织增生及胶原纤维沉积;与模型组比较,龙葵低、中、高剂量组及水飞蓟宾胶囊组能显著改善大鼠肝组织中肝细胞结构、水肿、炎细胞浸润、结缔组织增生及胶原纤维沉积;与空白组比较,模型组大鼠血清中ALT、AST、PCIII、ColIV、LN、HA含量显著升高(P<0.01),与模型组比较,各治疗组血清中ALT、AST、PCIII、ColIV、LN、HA含量明显降低(P<0.05);Real-time PCR及Western blot结果显示,与空白组比较,模型组中Bcl-2 mRNA和蛋白表达显著升高,Bax及Caspase-3 mRNA和蛋白显著下降(P<0.01);与模型组比较,各治疗组中Bcl-2 mRNA和蛋白表达降低,Bax及Caspase-3mRNA和蛋白表达明显上升(P<0.05),其中龙葵高剂量组疗效最佳。结论:龙葵通过调节Bcl-2/Bax/Caspase-3通路,调控细胞凋亡改善大鼠肝纤维化进程。 展开更多
关键词 肝纤维化 龙葵 B细胞淋巴瘤-2/B细胞淋巴瘤-2相关X蛋白/胱天蛋白酶-3(Bcl-2/Bax/Caspase-3)信号通路 细胞凋亡
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根皮苷通过调节IRS-1/PI3K/Akt信号通路改善T2DM大鼠的糖脂代谢紊乱 认领 引用 被引量：8
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作者 努尔·艾力 曹清雨 +3 位作者 刘欢 何军伟 钟卫红 曹岚 《中国实验方剂学杂志》 CAS CSCD 北大核心 2026年第3期139-148,共10页
目的:观察根皮苷改善2型糖尿病(T2DM)大鼠肝脏糖脂代谢紊乱的药效学作用,并基于胰岛素受体底物-1(IRS-1)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)通路探讨其作用机制。方法:采用高脂饲料和链脲佐菌素(STZ)建立T2DM大鼠模型,分为空白组,... 目的:观察根皮苷改善2型糖尿病(T2DM)大鼠肝脏糖脂代谢紊乱的药效学作用,并基于胰岛素受体底物-1(IRS-1)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)通路探讨其作用机制。方法:采用高脂饲料和链脲佐菌素(STZ)建立T2DM大鼠模型,分为空白组,模型组,二甲双胍组(300 mg·kg-1),根皮苷高、低剂量组(100、25 mg·kg-1),灌胃给药6周,观察大鼠体质量和空腹血糖(FBG)的变化,开展口服葡萄糖耐量实验(OGTT);全自动生化分析仪检测血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)、糖化血清蛋白(GSP)水平、天冬氨酸氨基转移酶(AST),丙氨酸氨基转移酶(ALT);酶联免疫吸附测定法(ELISA)检测空腹胰岛素(FINS)、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α;生化法测定肝脏中超氧化物歧化酶(SOD)、丙二醛(MDA)水平;计算胰腺指数、肝脏指数、胰岛素抵抗指数;苏木素-伊红(HE)染色观察大鼠肝脏和胰腺病理变化,免疫荧光法(IF)检测胰腺组织中胰岛素和胰高血糖素的变化;蛋白免疫印迹法(Western blot)检测肝脏组织IRS-1/PI3K/Akt通路相关蛋白及其下游糖原合酶激酶-3β(GSK-3β)和叉头盒转录因子O1(FoxO1)蛋白的表达。结果:与空白组比较,模型组大鼠体质量持续下降、FBG水平明显升高,OGTT血糖曲线下面积(AUC)、GSP、TC、TG、LDL-C、MDA、IL-1β、IL-6、TNF-α水平及胰腺指数、肝脏指数、胰岛素抵抗指数明显升高,HDL-C、SOD、FINS水平明显降低(P<0.05,P<0.01);组织学结果显示,模型组大鼠胰岛萎缩,呈现显著结构紊乱,胰岛素阳性β细胞显著减少(P<0.01),胰高血糖素阳性α细胞显著增加(P<0.01);模型组大鼠肝有炎性细胞浸润,部分细胞坏死,而且肝脏磷酸化(p)-IRS-1/IRS-1、p-GSK-3β/GSK-3β、p-FoxO1/FoxO1蛋白表达显著升高(P<0.01),p-PI3K/PI3K、p-Akt/Akt蛋白表达显著降低(P<0.01)。与模型组比较,各给药组大鼠糖尿病症状有所改善,体质量和FBG变化趋势接近空白组,OGTT-AUC、GSP、TC、TG、LDL-C、MDA、IL-1β、IL-6、TNF-α水平及胰腺指数、肝脏指数、胰岛素抵抗指数明显减少(P<0.05,P<0.01),HDL-C、SOD、FINS水平明显升高(P<0.05,P<0.01);各给药组大鼠胰腺和肝脏病理改变得到有效改善,胰腺中胰岛素阳性β细胞显著增加(P<0.01),胰高血糖素阳性α细胞显著减少(P<0.01),肝脏中p-IRS-1/IRS-1、p-GSK-3β/GSK-3β、p-FoxO1/FoxO1蛋白表达显著减少(P<0.01),p-PI3K/PI3K、p-Akt/Akt蛋白表达显著升高(P<0.01)。结论:根皮苷逆转T2DM大鼠出现的体质量减轻和FBG异常升高,改善血脂、氧化应激、炎症水平,缓解胰岛素抵抗,且对肝脏和胰腺有一定的保护作用,其降糖作用机制可能是通过调节IRS-1/PI3K/Akt信号通络,降低GSK-3β和FoxO1活性,促进肝脏糖原合成,抑制肝脏糖异生功能,进而发挥改善糖脂代谢紊乱。 展开更多
关键词 根皮苷 胰岛素受体底物-1(IRS-1)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt) 2型糖尿病(T2DM) 胰岛素抵抗 糖脂代谢
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长江流域典型水源水库春季2-甲基异莰醇浓度及其影响因素 认领 引用 被引量：4
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作者 韦彦章 朱广伟 +2 位作者 池怡 黄昌春 肖曼 《湖泊科学》 EI CAS CSCD 北大核心 2026年第1期78-90,共13页
春末夏初是长江流域水源水库水质异味问题的高发期,但关于该区域水库异味物质发生特征及影响因子尚不明晰。2024年5月调查了长江流域上、中、下游不同省份9座水源水库坝前区域水体2-甲基异莰醇(2-MIB)等异味物质浓度状况及其环境条件,... 春末夏初是长江流域水源水库水质异味问题的高发期,但关于该区域水库异味物质发生特征及影响因子尚不明晰。2024年5月调查了长江流域上、中、下游不同省份9座水源水库坝前区域水体2-甲基异莰醇(2-MIB)等异味物质浓度状况及其环境条件,探讨了春季影响该区域水源水库异味物质浓度的生态环境因子。结果表明,2-MIB是春季长江流域水源水库中最常见的超标异味物质,9座水库坝前水柱2-MIB浓度均值为35.5 ng/L,超过《生活饮用水卫生标准》中该物质控制浓度阈值(10.0 ng/L)的样品数占比为59.4%;相比而言,土臭素均值仅为2.9 ng/L,超过《生活饮用水卫生标准》中该物质控制浓度阈值(10.0 ng/L)的样品数占比仅为12.5%;异味物质β-环柠檬醛的均值为18.2 ng/L,β-环紫罗兰酮的均值为7.2 ng/L,引起饮用水异味问题的风险小。2-MIB的源解析表明,假鱼腥藻(Pseudanabaena sp.)可能是该区域水源水库中2-MIB的主要来源,其细胞密度与2-MIB浓度呈显著正相关;但也存在部分水库检测到2-MIB但未检出假鱼腥藻的现象,反映出2-MIB来源的复杂性。富营养化会导致2-MIB异味问题风险显著升高,2-MIB浓度与水体营养状态指数呈正相关。调查前一周内的累计降雨量与2-MIB浓度呈负相关,推测短期强降雨等气象条件变化会通过显著改变水柱混合作用、引起藻类群落演替等方式导致水库2-MIB浓度突变。研究表明,虽然长江流域的水源水库大都处于中营养水平,但普遍面临2-MIB超标的水质异味风险。加强外源营养盐入库负荷控制,优化库体食物链结构,进一步降低水库营养状态,有助于提升水库型水源地的供水质量。 展开更多
关键词 长江流域 水源水库 中营养 2-甲基异莰醇 假鱼腥藻
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信号分子自诱导物-2(AI-2)通过Tar1调节伸长盐单胞菌的趋化运动和生物膜形成 认领 引用 被引量：1
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作者 王卓 魏嘉倓 +5 位作者 杨艳艳 郭欣 王传旭 杨静 牛亚洁 李新 《微生物学报》 CAS CSCD 北大核心 2026年第2期770-782,共13页
自诱导物-2(autoinducer-2,AI-2)是一种广泛存在于细菌中的种间群体感应信号分子,参与调解生物发光、趋化运动以及生物膜形成等许多重要的生理过程。然而,AI-2对伸长盐单胞菌(Halomonas elongata)的影响及其作用机制尚未见报道。【目的... 自诱导物-2(autoinducer-2,AI-2)是一种广泛存在于细菌中的种间群体感应信号分子,参与调解生物发光、趋化运动以及生物膜形成等许多重要的生理过程。然而,AI-2对伸长盐单胞菌(Halomonas elongata)的影响及其作用机制尚未见报道。【目的】揭示伸长盐单胞菌中信号分子AI-2的受体蛋白,并检测AI-2通过受体蛋白对伸长盐单胞菌趋化运动和生物膜形成能力产生的影响。【方法】采用毛细管定量分析法检测伸长盐单胞菌对AI-2的趋化响应;通过对甲基趋化受体蛋白进行结构域分析、序列比对和分子对接找到AI-2的潜在受体蛋白Tar1及其关键氨基酸位点;表达并纯化Tar1的配体结合结构域(ligand-binding domain,LBD)蛋白及其点突蛋白,通过哈维氏弧菌发光试验检测Tar1-LBD是否结合信号分子AI-2;运用同源重组技术构建tar1基因缺失突变体,并通过毛细管定量分析和生物膜形成试验检测AI-2对伸长盐单胞菌趋化运动和生物膜形成的影响。【结果】毛细管定量分析法显示伸长盐单胞菌对信号分子AI-2表现出趋向性。在伸长盐单胞菌中共找到4个甲基受体趋化蛋白,结构域分析、序列比对、分子对接以及哈维氏弧菌发光试验表明Tar1-LBD能够结合信号分子AI-2。利用同源重组技术成功构建了伸长盐单胞菌tar1基因缺失突变体,tar1基因的缺失会抑制伸长盐单胞菌对AI-2的趋化响应,而互补菌株的趋化响应可恢复到接近野生型的水平。此外,生物膜形成试验检测显示,AI-2能够通过Tar1促进伸长盐单胞菌的生物膜形成。【结论】伸长盐单胞菌对信号分子AI-2具有趋化性,AI-2通过结合甲基趋化受体蛋白Tar1的配体结合结构域来调控伸长盐单胞菌的趋化运动和生物膜形成。 展开更多
关键词 伸长盐单胞菌 自诱导物-2(AI-2) 受体蛋白 趋化性 生物膜形成
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