Iodide ions can form crystal lattices with large interstitial spaces,making them archetypal systems for investigating superionic phase transitions.Understanding how iodine-based lattices evolve under different thermod...Iodide ions can form crystal lattices with large interstitial spaces,making them archetypal systems for investigating superionic phase transitions.Understanding how iodine-based lattices evolve under different thermodynamic conditions is therefore a central problem in condensed matter physics and functional materials design.Aluminum iodide(AlI3)is a molecular solid crystal with low ionic conductivity under ambient conditions,and it plays important roles in batteries and catalytic applications,motivating exploration of its pressure-tunable ionic transport behavior.Here,we reveal the pressure-induced structural dimensionality evolution in AlI3 through first-principles structural searches and synchrotron X-ray diffraction(XRD).We identify a sequence of phase transitions:from the molecular P21/c phase to a two-dimensional layered rhombohedral(R-3)phase above 1.3 GPa,and subsequently to a one-dimensional chain-like orthorhombic(Cmcm)phase beyond 49 GPa.Notably,in situ laser-heating XRD and ab initio molecular dynamics simulations reveal that the R-3 phase undergoes a transition to a superionic state at high temperatures,where Al3+ions undergo partially disordered,rapid diffusion within the rigid iodine layers.We further demonstrate that the introduction of Al3+vacancies substantially reduces the superionic transition temperature.Our work not only maps the structural evolution of AlI3 under pressure,but also provides a key reference for the structural design of metal halides under high pressure.展开更多
The awn can contribute to photosynthesis and carbohydrates,enhancing grain yield in wheat.We mapped QAwn.sxau-5A,a major QTL for awn development in wheat(Triticum aestivum).This QTL was delimited to a 994-kb interval ...The awn can contribute to photosynthesis and carbohydrates,enhancing grain yield in wheat.We mapped QAwn.sxau-5A,a major QTL for awn development in wheat(Triticum aestivum).This QTL was delimited to a 994-kb interval at the B1 locus on chromosome 5A,which included the candidate gene encoding a zinc finger protein(TraesCS5A01G542800)as an awn length inhibitor(ALI).The Ali-A1 allele for the awnless trait showed abundant sequence differences in the promoter regions compared to the ali-A1 allele for the long-awn trait.The results of the swap experiment on the promoters from the two ALI-A1 alleles showed that the two promoters caused a difference in the protein level,indicating the gene was regulated at the transcript level.However,the ali-A1 allele contained an SNP that caused a premature stop codon in its coding region,resulting in a truncated protein compared to the functional Ali-A1 protein.The Ali-A1 protein contained two ethylene-responsive element binding factor-associated amphiphilic repression(EAR)motifs,one at the N terminus(EAR-N)and the other at the C terminus(EAR-C),and they were involved in interactions with the wheat co-repressor protein TOPLESS(TPL1).The ali-A1 protein retained the EAR-N motif but lost the EAR-C motif,resulting in the attenuated ability to interact with TPL1.The tpl1 mutant produced a longer awn compared to the wild type.Ali-A1 repressed the transcription of two downstream genes,TaLRP-A1 and TaARF-B1,involved in endogenous auxin concentrations and auxin responses in wheat.We concluded that the awn length is regulated not only by the ALI-A1 gene at transcript levels but also by Ali-A1 and TPL1 at the protein level in wheat.展开更多
In July, the Ali CMB Polarization Telescope(Ali CPT) officially released high-quality maps of 150 GHz radiation from the Moon and Jupiter. The quality of these images not only validates the exceptional performance of ...In July, the Ali CMB Polarization Telescope(Ali CPT) officially released high-quality maps of 150 GHz radiation from the Moon and Jupiter. The quality of these images not only validates the exceptional performance of the core instrument of Ali CPT-1 but also signifies the successful completion of its first-stage construction.Designed to detect primordial gravitational waves(PGWs - the faint echoes of the Big Bang) by measuring the B-mode polarization of cosmic microwave background(CMB) radiation, Ali CPT is situated on a mountain ridge at an altitude of 5,250 meters in the Ali Region of Xizang, China.展开更多
BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality...BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.展开更多
The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter telescope which is proposed to be built in western China.The site selection for LOT in China began in 2016,and Ali was listed as one of the thre...The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter telescope which is proposed to be built in western China.The site selection for LOT in China began in 2016,and Ali was listed as one of the three candidate sites.Remote studies and local surveys have been carried out for more than 15 years in western China,and the results show that Ali is a promising site with comprehensive quality in terms of atmospheric and supporting conditions.An overview of the site testing campaign at the Ali site from 2016 to 2019 is presented.After the two years of data collection,the overall median seeing value is found to be 1.17 arcsec,the observable nights are 81.71%and the good observable nights are 71.76%.The weather conditions as follows,the median night temperature value is-5.18℃,the median night relative humidity value is 41.25%,the median night atmospheric pressure value is 540.92 hPa,the median night wind speed value is 7.41 m s-1 and the mainly wind direction is southwestern(SW).The median night sky background value is 22.07 magV.We also discuss the wind speed at different locations on-site,the possibility of light pollution and the effect of wind speed on differential image motion monitor(DIMM)seeing measurements.展开更多
This paper sheds light on the Iraqi personality in light of writings of the Iraqi eminent sociologist Dr. Ali Al-Wardi and gives a critical review to his main findings and hypotheses. Al-Wardi was the main person who ...This paper sheds light on the Iraqi personality in light of writings of the Iraqi eminent sociologist Dr. Ali Al-Wardi and gives a critical review to his main findings and hypotheses. Al-Wardi was the main person who established the first department of sociology in Iraq and the spiritual father or the real father of sociology in the country. He wrote prestigious works about the Iraqi society including some hypotheses focusing on the Iraqi personality, such as the dual personality and social dissonance. These findings and hypotheses are not above criticism of course. The method we depend on here is the content analysis methodology. The paper consists of seven parts; part one is the introduction which includes a short glimpse on the subject and A1-Wardi's methodology. Part two deals with Al-Wardi and studying Iraqi personality. Part three, discusses the dual personality, and part four, the social dissonance. Part five, exposures tackling the problem where Al-Wardi suggests some points. Part six deals with the discussion. Finally, there is a conclusion under the part seven.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.11974154,42150101,12304278,and T2425016)the Taishan Scholars Special Funding for Construction Projects(Grant No.tstp20230622)+1 种基金the Natural Science Foundation of Shandong Province(Grant Nos.ZR2022MA004,ZR2023QA127,and ZR2024QA121)the Special Foundation of Yantai for Leading Talents above Provincial Level.
摘要Iodide ions can form crystal lattices with large interstitial spaces,making them archetypal systems for investigating superionic phase transitions.Understanding how iodine-based lattices evolve under different thermodynamic conditions is therefore a central problem in condensed matter physics and functional materials design.Aluminum iodide(AlI3)is a molecular solid crystal with low ionic conductivity under ambient conditions,and it plays important roles in batteries and catalytic applications,motivating exploration of its pressure-tunable ionic transport behavior.Here,we reveal the pressure-induced structural dimensionality evolution in AlI3 through first-principles structural searches and synchrotron X-ray diffraction(XRD).We identify a sequence of phase transitions:from the molecular P21/c phase to a two-dimensional layered rhombohedral(R-3)phase above 1.3 GPa,and subsequently to a one-dimensional chain-like orthorhombic(Cmcm)phase beyond 49 GPa.Notably,in situ laser-heating XRD and ab initio molecular dynamics simulations reveal that the R-3 phase undergoes a transition to a superionic state at high temperatures,where Al3+ions undergo partially disordered,rapid diffusion within the rigid iodine layers.We further demonstrate that the introduction of Al3+vacancies substantially reduces the superionic transition temperature.Our work not only maps the structural evolution of AlI3 under pressure,but also provides a key reference for the structural design of metal halides under high pressure.
基金supported by the Grand Science and Technology Special Project in Shanxi Province(202201140601025-2)the National Natural Science Foundation of China(32201749)supported by the Agriculture and Food Research Initiative Competitive Grant 2022-68013-36439(WheatCAP)from the USDA National Institute of Food and Agriculture.
摘要The awn can contribute to photosynthesis and carbohydrates,enhancing grain yield in wheat.We mapped QAwn.sxau-5A,a major QTL for awn development in wheat(Triticum aestivum).This QTL was delimited to a 994-kb interval at the B1 locus on chromosome 5A,which included the candidate gene encoding a zinc finger protein(TraesCS5A01G542800)as an awn length inhibitor(ALI).The Ali-A1 allele for the awnless trait showed abundant sequence differences in the promoter regions compared to the ali-A1 allele for the long-awn trait.The results of the swap experiment on the promoters from the two ALI-A1 alleles showed that the two promoters caused a difference in the protein level,indicating the gene was regulated at the transcript level.However,the ali-A1 allele contained an SNP that caused a premature stop codon in its coding region,resulting in a truncated protein compared to the functional Ali-A1 protein.The Ali-A1 protein contained two ethylene-responsive element binding factor-associated amphiphilic repression(EAR)motifs,one at the N terminus(EAR-N)and the other at the C terminus(EAR-C),and they were involved in interactions with the wheat co-repressor protein TOPLESS(TPL1).The ali-A1 protein retained the EAR-N motif but lost the EAR-C motif,resulting in the attenuated ability to interact with TPL1.The tpl1 mutant produced a longer awn compared to the wild type.Ali-A1 repressed the transcription of two downstream genes,TaLRP-A1 and TaARF-B1,involved in endogenous auxin concentrations and auxin responses in wheat.We concluded that the awn length is regulated not only by the ALI-A1 gene at transcript levels but also by Ali-A1 and TPL1 at the protein level in wheat.
基金Sponsored by CAS,the Chinese Ministry of Science and Technology and the National Natural Science Foundation of China,the project is anticipated to break through on the frontiers of fundamental physics,astrophysics and cosmology.
摘要In July, the Ali CMB Polarization Telescope(Ali CPT) officially released high-quality maps of 150 GHz radiation from the Moon and Jupiter. The quality of these images not only validates the exceptional performance of the core instrument of Ali CPT-1 but also signifies the successful completion of its first-stage construction.Designed to detect primordial gravitational waves(PGWs - the faint echoes of the Big Bang) by measuring the B-mode polarization of cosmic microwave background(CMB) radiation, Ali CPT is situated on a mountain ridge at an altitude of 5,250 meters in the Ali Region of Xizang, China.
基金Supported by Biotropics Malaysia Berhad,Malaysia,NN-2021-016.
摘要BACKGROUND Herbal supplements are increasingly used to manage menopausal symptoms.Physta®is a commercial herbal ingredient containing Eurycoma longifolia standardized water extract,traditionally used for vitality.Its adaptogenic and anti-inflammatory properties promote hormonal balance,physical function,and sexual health,supporting its potential benefits for menopausal health.AIM To investigate Physta®’s role in improving menopausal quality of life,mood states,and overall safety profile compared with placebo.METHODS In this 12-week,randomized,double-blind,placebo-controlled trial,138 females aged 40-55 with menopausal symptoms were randomly assigned to receive Physta®50 mg,Physta®100 mg,or placebo.MENQOL and POMS were assessed at baseline,week 6,and week 12.Safety outcomes were evaluated through biochemical tests,vital signs,and female reproductive hormonal profile.RESULTS Physta®100 mg significantly reduced total MENQOL scores by 33.9%from baseline to week 12(P=0.049)with notable improvements in the physical(-36.4%,P=0.046)and sexual(-36.3%,P=0.043)domains.Total mood disturbance also declined more in the Physta®100 mg group(-38.6%)compared with placebo(-30.1%),although not statistically significant.No significant changes were observed in the vital signs and biochemical parameters,indicating the safety and tolerability of Physta®.No significant alterations were found in the female reproductive hormone profile,supporting its hormonal neutrality.CONCLUSION Physta®100 mg improved menopausal quality of life and mood without adverse effects,supporting its potential as a safe herbal therapy.Further studies with higher doses and longer durations are needed.
基金funded by the National Natural Science Foundation of China(NSFC,Grant Nos.11873063 and 11373043)supported by the Operation,Maintenance and Upgrading Fund for Astronomical Telescopes and Facility Instruments,budgeted from the Ministry of Finance of China(MOF)and administrated by CASsupported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB23020300)。
摘要The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter telescope which is proposed to be built in western China.The site selection for LOT in China began in 2016,and Ali was listed as one of the three candidate sites.Remote studies and local surveys have been carried out for more than 15 years in western China,and the results show that Ali is a promising site with comprehensive quality in terms of atmospheric and supporting conditions.An overview of the site testing campaign at the Ali site from 2016 to 2019 is presented.After the two years of data collection,the overall median seeing value is found to be 1.17 arcsec,the observable nights are 81.71%and the good observable nights are 71.76%.The weather conditions as follows,the median night temperature value is-5.18℃,the median night relative humidity value is 41.25%,the median night atmospheric pressure value is 540.92 hPa,the median night wind speed value is 7.41 m s-1 and the mainly wind direction is southwestern(SW).The median night sky background value is 22.07 magV.We also discuss the wind speed at different locations on-site,the possibility of light pollution and the effect of wind speed on differential image motion monitor(DIMM)seeing measurements.
摘要This paper sheds light on the Iraqi personality in light of writings of the Iraqi eminent sociologist Dr. Ali Al-Wardi and gives a critical review to his main findings and hypotheses. Al-Wardi was the main person who established the first department of sociology in Iraq and the spiritual father or the real father of sociology in the country. He wrote prestigious works about the Iraqi society including some hypotheses focusing on the Iraqi personality, such as the dual personality and social dissonance. These findings and hypotheses are not above criticism of course. The method we depend on here is the content analysis methodology. The paper consists of seven parts; part one is the introduction which includes a short glimpse on the subject and A1-Wardi's methodology. Part two deals with Al-Wardi and studying Iraqi personality. Part three, discusses the dual personality, and part four, the social dissonance. Part five, exposures tackling the problem where Al-Wardi suggests some points. Part six deals with the discussion. Finally, there is a conclusion under the part seven.