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Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis 认领 引用 被引量：1
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作者 Tomas Koky Sylvia Drazilova +7 位作者 Slavomira Komarova Marian Macej Dominika Toporcerova Martin Janicko Ivana Spakova Miroslava Rabajdova Maria Marekova Peter Jarcuska 《World Journal of Hepatology》 2026年第2期209-223,共15页
BACKGROUND Primary biliary cholangitis(PBC)is a rare,nonsuppurative cholestatic disease that affects the small intrahepatic bile ducts.If not adequately managed,it may progress to liver cirrhosis and hepatocellular ca... BACKGROUND Primary biliary cholangitis(PBC)is a rare,nonsuppurative cholestatic disease that affects the small intrahepatic bile ducts.If not adequately managed,it may progress to liver cirrhosis and hepatocellular carcinoma.Only a few studies have explored the impact of cardiometabolic risk factors on liver fibrosis progression in PBC.Relevant data on the role of adipokines in these processes are also limited.AIM To compare leptin and adiponectin levels in PBC patients stratified by the presence of metabolic dysfunction-associated steatotic liver disease(MASLD),metabolic syndrome(MetS),fibrosis,and biochemical response.METHODS We conducted a cross-sectional study involving 81 PBC patients diagnosed according to European Association for the Study of the Liver guidelines,all followed at a tertiary care center in Košice,Slovakia.Patients were included consecutively from the patient database in hepatology clinic in a prospective manner.Data on biochemical,clinical and anthropometric variables and their associations with MASLD,MetS,fibrosis,and biochemical response were evaluated using statistical methods including logistic regression and receiver operating characteristic analysis.RESULTS Patients with PBC/MASLD had significantly lower adiponectin levels(1698.24 pg/mL vs 2042.08 pg/mL,P=0.015)and higher leptin levels(1.89 ng/mL vs 0.62 ng/mL,P0.05).CONCLUSION Adipokines reflect metabolic status in PBC.The L/A ratio is promising biomarker for MASLD.No significant association between leptin and adiponectin levels and advanced fibrosis was detected within the limited sample size of this study. 展开更多
关键词 Primary biliary cholangitis Adipokines Liver fibrosis Metabolic dysfunction-associated steatotic liver disease Metabolic syndrome
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Body composition and adipokines in pregnant women:Associations with gestational diabetes mellitus risk 认领 引用
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作者 Lan Li Yan-Chao Mu +3 位作者 Da-Wei Wang Jie Du Zhi-Jun Zhang Feng-Jiao Wang 《World Journal of Diabetes》 SCIE 2026年第1期97-106,共10页
BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance first identified during pregnancy.Adipokines are adipose-derived hormones regulating insulin sensitivity,while body composition desc... BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance first identified during pregnancy.Adipokines are adipose-derived hormones regulating insulin sensitivity,while body composition describes the body’s fat and non-fat components,which change dynamically in gestation.AIM To explore the associations between body composition,adipokines,and GDM risk,identifying early predictive markers to enhance prenatal risk assessment.METHODS A retrospective analysis included 1656 singleton pregnant women(276 with GDM,1380 with normal glucose tolerance)from 2020-2024.Early pregnancy(6-16 weeks)body composition was assessed via bioelectrical impedance analysis.Adipokines(leptin,adiponectin,fatty acid-binding protein 4)and metabolic indices were measured during 24-28 weeks oral glucose tolerance test.Group comparisons,logistic regression,correlation analysis,and receiver operating characteristic curves were used to evaluate relationships and diagnostic performance.RESULTS GDM women had higher pre-pregnancy body mass index(BMI),glucose/insulin,homeostasis model assessment of insulin resistance,lower insulin sensitivity index(all P<0.05).GDM showed higher fat mass percentage(FMP)(36.23%±7.54%vs 33.12%±9.87%),fat mass index(FMI)(9.87±3.32 kg/m2vs 8.34±4.11 kg/m2),extracellular-to-intracellular water ratio(ECW/ICW)(0.63±0.03 vs 0.61±0.02),lower lean mass indices(all P<0.001 except ECW/ICW P=0.012).GDM had higher leptin(P=0.014),lower adiponectin(P=0.021).FMP elevation was independent risk factor(odds ratio=1.412,P=0.030).Pre-pregnancy BMI(area under the curve=0.662),FMP(0.651),FMI(0.650)had better diagnostic value than ECW/ICW(0.606).CONCLUSION Body composition parameters(FMP,FMI)and adipokines(leptin,adiponectin)are closely linked to GDM risk.Integrating these assessments into prenatal care facilitates early risk identification and targeted interventions to improve maternal-fetal outcomes. 展开更多
关键词 Gestational diabetes mellitus Body composition Adipokines Insulin resistance Risk prediction
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Aqueous humor adipokine profile of primary open angle glaucoma patients and cataract patients with or without metabolic disorders 认领 引用
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作者 Zi-Yao Xia Ke Xu +6 位作者 Wei-Jia Zhang De-Fu Wu Zhe Pan Hao-Cheng Xian Xue-Min Li Huai-Zhou Wang Chun Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2025年第4期615-626,共12页
AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorde... AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities. 展开更多
关键词 glaucoma biomarkers adipokine primary open angle glaucoma aqueous humor metabolic disorder
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Effect of adipokines on bone marrow mesenchymal stem cell function 认领 引用
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作者 Rui-Ming Wen Hai-Xia Wang 《World Journal of Stem Cells》 SCIE 2025年第5期54-65,共12页
During excessive adipose tissue accumulation,various adipokines such as visfatin,chemerin,vaspin,and adiponectin are released into systemic circulation,thereby influencing metabolic tissue function throughout the body... During excessive adipose tissue accumulation,various adipokines such as visfatin,chemerin,vaspin,and adiponectin are released into systemic circulation,thereby influencing metabolic tissue function throughout the body.As multifunctional signaling molecules secreted by adipose tissue,adipokines play a pivotal role in metabolic regulation,inflammatory response,and tissue homeostasis.Recent studies have demonstrated that adipokines can influence skeletal system repair and regeneration by modulating bone marrow-derived mesenchymal stem cell(BMSC)proliferation,differentiation,migration,and immunomodulatory functions.However,different adipokines have distinct roles in regulating BMSC function,but their underlying molecular mechanisms are not fully understood.In this review,we systematically summarize the specific mechanisms of action and potential clinical applications of visfatin,chemerin,vaspin,and adiponectin on BMSC function in order to reveal new mechanisms of interaction between adipokines and BMSCs.The aim is to provide a theoretical basis for targeted treatment strategies for bone diseases targeting adipokines. 展开更多
关键词 Adipokine Bone marrow-derived mesenchymal stem cells Osteogenic differentiation Adipogenic differentiation Chondrogenic differentiation
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GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells 认领 引用 被引量：8
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作者 Xiao-Min Xin Mu-Xiao Zhong +3 位作者 Gong-Li Yang Yao Peng Ya-Li Zhang Wei Zhu 《World Journal of Gastroenterology》 SCIE CAS 2014年第42期15727-15735,共9页
AIM: To investigate the effect of GW4064 on the expression of adipokines and their receptors during differentiation of 3T3-L1 preadipocytes and in HepG2 cells.
关键词 Farnesoid X receptor Adipokines Adipokine receptors 3T3-L1 cells HepG2 cells Nonalcoholic fatty liver disease
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Association between obesity-related adipokines and colorectal cancer:A case-control study and meta-analysis 认领 引用 被引量：12
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作者 Rakhi Kumari Joshi Woo Jin Kim Sang-Ah Lee 《World Journal of Gastroenterology》 SCIE CAS 2014年第24期7941-7949,共9页
AIM: To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-&#x003b1; (TNF-&#x003b1;) and colorectal cancer (CRC) risk.
关键词 Obesity Colorectal cancer Cancer risk Adipokines Obesity-related adipokines
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Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis 认领 引用 被引量：9
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作者 Maria Kalafateli Christos Triantos +8 位作者 Emmanuel Tsochatzis Marina Michalaki Efstratios Koutroumpakis Konstantinos Thomopoulos Venetsanea Kyriazopoulou Eleni Jelastopulu Andrew Burroughs Chryssoula Lambropoulou-Karatza Vasiliki Nikolopoulou 《World Journal of Gastroenterology》 SCIE CAS 2015年第10期3020-3029,共10页
AIM:To investigate the adipokine levels of leptin,adiponectin,resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,male... AIM:To investigate the adipokine levels of leptin,adiponectin,resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,males:35(87.5%),Child-Pugh(CP)score:median 7(5-12),CP A/B/C:18/10/12,Model for End-stage Liver Disease(MELD):median 10(6-25),follow-up:median 32.5 mo(10-43)]were prospectively included.The serum adipokine levels were estimated in duplicate by ELISA.Somatometric characteristics were assessed with tetrapolar bioelectrical impedance analysis.Pearson’s rank correlation coefficient was used to assess possible associations with adipokine levels.Univariate and multivariate Cox regression analysis was used to determine independent predictors for overallsurvival.RESULTS:Body mass index:median 25.9(range:20.1-39.3),fat:23.4%(7.6-42.1),fat mass:17.8(5.49-45.4),free fat mass:56.1(39.6-74.4),total body water(TBW):40.6(29.8-58.8).Leptin and visfatin levels were positively associated with fat mass(P<0.001/P=0.027,respectively)and RBP4 with TBW(P=0.025).Median adiponectin levels were significantly higher in CPC compared to CPA(CPA:7.99±14.07,CPB:7.66±3.48,CPC:25.73±26.8,P=0.04),whereas median RBP4 and apelin levels decreased across the spectrum of disease severity(P=0.006/P=0.034,respectively).Following adjustment for fat mass,visfatin and adiponectin levels were significantly increased from CPA to CPC(both P<0.001),whereas an inverse correlation was observed for both RBP4 and apelin(both P<0.001).In the multivariate Cox regression analysis,only MELD had an independent association with overall survival(HR=1.53,95%CI:1.05-2.32;P=0.029).CONCLUSION:Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis. 展开更多
关键词 Adipokines Adiponectin Cirrhosis Leptin Resistin
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Serum adipokines in inflammatory bowel disease 认领 引用 被引量：17
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作者 Marek Waluga Marek Hartleb +2 位作者 Grzegorz Boryczka Micha Kukla Krystyna Zwirska-Korczala 《World Journal of Gastroenterology》 SCIE CAS 2014年第22期6912-6917,共6页
AIM: To investigate serum adipokine levels in inflammatory bowel disease (IBD) patients before treatment and after achieving clinical remission.
关键词 Adipokines Tumor growth factor-β 1 Crohn’ s disease Ulcerative colitis Inflammatory bowel disease
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Hepatic steatosis,low-grade chronic inflammation and hormone/growth factor/adipokine imbalance 认领 引用 被引量：32
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作者 Giovanni Tarantino Silvia Savastano Annamaria Colao 《World Journal of Gastroenterology》 SCIE CAS 2010年第38期4773-4783,共11页
Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty... Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty acids and fatty infi ltration of the liver, which is known as hepatic steatosis. Hepatocyte apoptosis is a key feature of this disease and correlates with its severity. Free-fatty-acidinduced toxicity represents one of mechanisms for the pathogenesis of NAFLD and hormones, growth factors and adipokines influence also play a key role. This review highlights the various pathways that contribute to the development of hepatic steatosis. Circulating concentrations of inflammatory cytokines are reckoned to be the most important factor in causing and maintaining IR. Low-grade chronic inflammation is fundamental in the progression of NAFLD toward higher risk cirrhotic states. 展开更多
关键词 Hepatic steatosis Low-grade chronic inflammation Adipokines Hormones Growth factors
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Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease 认领 引用 被引量：8
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作者 Raika Jamali Mohsen Razavizade +1 位作者 Abbas Arj Mohammad Hossein Aarabi 《World Journal of Gastroenterology》 SCIE CAS 2016年第21期5096-5103,共8页
AIM: To assess significance of serum adipokines to determine the histological severity of non-alcoholic fatty liver disease.METHODS: Patients with persistent elevation in serum aminotransferase levels and well-defined... AIM: To assess significance of serum adipokines to determine the histological severity of non-alcoholic fatty liver disease.METHODS: Patients with persistent elevation in serum aminotransferase levels and well-defined characteristics of fatty liver at ultrasound were enrolled. Individuals with a history of alcohol consumption, hepatotoxic medication, viral hepatitis or known liver disease were excluded. Liver biopsy was performed to confirm nonalcoholic liver disease(NAFLD). The degrees of liver steatosis, lobular inflammation and fibrosis were determined based on the non-alcoholic fatty liver activity score(NAS) by a single expert pathologist. Patients with a NAS of five or higher were considered to have steatohepatitis. Those with a NAS of two or lower were defined as simple fatty liver. Binary logistic regression was used to determine the independent association of adipokines with histological findings. Receiver operating characteristic(ROC) analysis was employed to determine cut-off values of serum adipokines to discriminate the grades of liver steatosis,lobular inflammation and fibrosis. RESULTS: Fifty-four participants aged 37.02 ± 9.82 were enrolled in the study. Higher serum levels of visfatin, IL-8, TNF-α levels were associated independently with steatosis grade of more than 33% [β = 1.08(95%CI: 1.03-1.14), 1.04(95%CI: 1.008-1.07), 1.04(95%CI: 1.004-1.08), P < 0.05]. Elevated serum IL-6 and IL-8 levels were associated independently with advanced lobular inflammation [β = 1.4(95%CI: 1.09-1.8), 1.07(95%CI: 1.003-1.15), P < 0.05]. Similarly, higher TNF-α, resistin, and hepcidin levels were associated independently with advanced fibrosis stage [β = 1.06(95%CI: 1.002-1.12), 19.86(95%CI: 2.79-141.19), 560.72(95%CI: 5.98-5255.33), P < 0.05]. Serum IL-8 and TNF-α values were associated independently with the NAS score, considering a NAS score of 5 as the reference value [β = 1.05(95%CI: 1.01-1.1), 1.13(95%CI: 1.04-1.22), P < 0.05]. CONCLUSION: Certain adipokines may determine the severity of NAFLD histology accurately. 展开更多
关键词 Non-alcoholic fatty liver disease Adipokine Histology Adiponectin Visfatin Resistin Hepcidin Interleukin Tumor necrosis factor
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Abnormal Adipokines Associated with Various Types of Obesity in Chinese Children and Adolescents 认领 引用 被引量：4
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作者 ZHANG MeiXian ZHAO XiaoYuan +5 位作者 LIMing CHENG Hong HOU DongQing WEN Yu Katherine CIANFLONE MI Jie 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第1期12-21,共10页
Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein （ASP） and complement C3 （C3） in various types of obesity （peripheral obesity, abdominal ... Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein （ASP） and complement C3 （C3） in various types of obesity （peripheral obesity, abdominal obesity and mixed obesity） in Chinese children and adolescents, and their relationships with body size and pubertal development. Methods Children and adolescents （n=3 508） aged 6 to 18 years, with 1 788 boys and 1 720 girls were assessed for body mass index, waist circumference, pubertal development, blood insulin, resistin, leptin, adiponectin, ASP and C3 levels. Three types of obesity [peripheral obesity （n=43）, abdominal obesity （n=473）, mixed obesity （n=1 187）] and non‐obese control （n=1 805） were defined with combined use of Chinese body mass index and waist circumference criteria. Results Serum resistin, leptin and adiponectin levels were higher in girls than those in boys （all P0.01）. Insulin and leptin increased and adiponectin decreased across five Tanner stages in both girls and boys （all P0.001）, while ASP changed only in girls （P0.001） and C3 only in boys （P0.001）. Insulin, leptin and ASP were higher, but adiponectin was lower in all three types of obesity vs. the non‐obese control （all P0.05）. The greatest abnormalities of all six adipokines were found in the mixed obesity group. With inclusion of body mass index and waist circumference in simultaneous regression analyses, both body size indices were independently and significantly correlated with insulin, leptin and adiponectin after age and gender adjustment. Compared with waist circumference, the body mass index was stronger in interpreting insulin, leptin, adiponectin and ASP levels, whereas it was weaker in explaining variance of plasma C3. Conclusions Obese children have a worse metabolic profile with high insulin, resistin, leptin, ASP and C3, and low adiponectin levels. The adipokine profile in mixed obesity is worse than that in peripheral or abdominal obesity. Identification of obese subjects with a malignant adipokine profile using a combination of body mass index and waist circumference is important for the prevention of obesity‐related disease. 展开更多
关键词 Adipokine Types of obesity Body mass index Waist circumference Child and adolescent Chinese
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Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease 认领 引用 被引量：5
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作者 Lucia Pacifico Mario Bezzi +4 位作者 Concetta Valentina Lombardo Sara Romaggioli Flavia Ferraro Stefano Bascetta Claudio Chiesa 《World Journal of Gastroenterology》 SCIE CAS 2013年第25期4007-4014,共8页
AIM: To investigate bone mineral density (BMD) in obese children with and without nonalcoholic fatty liver disease (NAFLD); and the association between BMD and serum adipokines, and high-sensitivity C-reactive protein... AIM: To investigate bone mineral density (BMD) in obese children with and without nonalcoholic fatty liver disease (NAFLD); and the association between BMD and serum adipokines, and high-sensitivity C-reactive protein (HSCRP). METHODS: A case-control study was performed. Cases were 44 obese children with NAFLD. The diagnosis of NAFLD was based on magnetic resonance imaging (MRI) with high hepatic fat fraction (≥ 5%). Other causes of chronic liver disease were ruled out. Controls were selected from obese children with normal levels of aminotransferases, and without MRI evidence of fatty liver as well as of other causes of chronic liver diseases. Controls were matched (1-to 1-basis) with thecases on age, gender, pubertal stage and as closely as possible on body mass index-SD score. All participants underwent clinical examination, laboratory tests, and whole body (WB) and lumbar spine (LS) BMD by dual energy X-ray absorptiometry. BMDZ-scores were calcu- lated using race and gender specific LMS curves. RESULTS: Obese children with NAFLD had a significantly lower LS BMDZ-score than those without NAFLD [mean, 0.55 (95%CI: 0.23-0.86) vs 1.29 (95%CI: 0.95-1.63); P < 0.01]. WB BMD Z-score was also decreased in obese children with NAFLD compared to obese children with no NAFLD, though borderline significance was observed [1.55 (95%CI: 1.23-1.87) vs 1.95 (95%CI: 1.67-2.10); P = 0.06]. Children with NAFLD had significantly higher HSCRP, lower adiponectin, but similar leptin levels. Thirty five of the 44 children with MRI-diagnosed NAFLD underwent liver biopsy. Among the children with biopsy-proven NAFLD, 20 (57%) had nonalcoholic steatohepatitis (NASH), while 15 (43%) no NASH. Compared to children without NASH, those with NASH had a significantly lower LS BMD Z-score [mean, 0.27 (95%CI: -0.17-0.71) vs 0.75 (95%CI: 0.13-1.39); P < 0.05] as well as a significantly lower WB BMD Z-score [1.38 (95%CI: 0.89-1.17) vs 1.93 (95%CI: 1.32-2.36); P < 0.05]. In multiple regression analysis, NASH (standardized β coefficient, -0.272; P < 0.01) and HSCRP (standardized β coefficient, -0.192; P < 0.05) were significantly and independently associated with LS BMD Z-score. Similar results were obtained when NAFLD (instead of NASH) was included in the model. WB BMD Z-scores were significantly and independently associated with NASH (standardized β coefficient, -0.248;P < 0.05) and fat mass (standardized β coefficient, -0.224;P < 0.05). CONCLUSION: This study reveals that NAFLD is associated with low BMD in obese children, and that systemic, low-grade inflammation may accelerate loss of bone mass in patients with NAFLD. 展开更多
关键词 Bone mineralization Dual energy X-ray absorptiometry Adipokines C-reactive protein Nonalcoholic fatty liver disease Children
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Effect of periodontal treatment on adipokines in type 2 diabetes 认领 引用 被引量：8
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作者 Hiroshi Ogawa Teerasak Damrongrungruang +4 位作者 Sayaka Hori Kaname Nouno Kumiko Minagawa Misuzu Sato Hideo Miyazaki 《World Journal of Diabetes》 2014年第6期924-931,共8页
The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvem... The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal. 展开更多
关键词 Adipokines Diabetes Periodontal disease Periodontal therapy
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Bo′s abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines 认领 引用 被引量：6
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作者 QIN Xihui PANG Jianli +1 位作者 XIONG Guan FENG Jie 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第6期1200-1208,共9页
OBJECTIVE:To investigate the effect of Bo′s abdominal acupuncture(BOAA)on fibroblast growth factor 21(FGF21)and its related adipokines in type 2 diabetes mellitus(T2DM)rats.METHODS:This study established obese T2DM r... OBJECTIVE:To investigate the effect of Bo′s abdominal acupuncture(BOAA)on fibroblast growth factor 21(FGF21)and its related adipokines in type 2 diabetes mellitus(T2DM)rats.METHODS:This study established obese T2DM rat model by high-fat diet(HFD)with a dose of streptozotocin(STZ,30 mg/kg).Obese T2DM rats were randomly subdivided into four groups(n=10):negative,BOAA,conventional acupuncture(COA group)and metformin group(Met group)groups.The biochemical parameters,mRNAs,and proteins were analyzed using enzyme-lined immunoassays kits,quantitative polymerase chain reaction and Western blot.RESULTS:Treatment with BOAA attenuated the histopathological changes in visceral fat and restored the alterations in the levels of body weight,fasting blood glucose(FBG),homeostasis model assessment for insulin resistance(HOMA-IR).BOAA treatment significantly decreased the levels of triglyceride,total cholesterol,low density lipoprotein cholesterol,leptin,and increased the serum levels of high-density lipoprotein cholesterol,fibroblast growth factor 21(FGF21),adiponectin(ADP),peroxisome proliferator-activated receptorγ(PPAR-γ),C-peptide(C-P)in obese T2DM rats.Furthermore,BOAA treatment significantly increased the mRNA expressions of FGF21,ADP,leptin,PPAR-γ,PPAR-αand adenosine 5‘-monophosphate(AMP)-activated protein kinase(AMPK).Besides,BOAA treatment upregulated the protein expressions of fibroblast growth factor receptors3(FGFR3),PPAR-α,extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK),AMPK,p-AMPK,Liver kinase B1(LKB1),phosphorylated LKB1(p-LKB1),acetyl-CoA carboxylase(ACC)and phosphorylated ACC(p-ACC),while downregulated the protein expressions of FGF21 and PPAR-γin visceral fat.CONCLUSIONS:BOAA treatment reduced FBG and body weight,and improved insulin sensitivity through regulating FGF21 signaling pathway and its related adipokine in obese T2DM rats. 展开更多
关键词 diabetes mellitus type 2 obesity fibroblast growth factors adipokines insulin resistance Bo′s abdominal acupuncture
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Adipokines regulate mesenchymal stem cell osteogenic differentiation 认领 引用 被引量：3
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作者 Zhong-Hua Xu Chen-Wei Xiong +5 位作者 Kai-Song Miao Zhen-Tang Yu Jun-Jie Zhang Chang-Lin Yu Yong Huang Xin-Die Zhou 《World Journal of Stem Cells》 SCIE 2023年第6期502-513,共12页
Mesenchymal stem cells(MSCs)can differentiate into various tissue cell types including bone,adipose,cartilage,and muscle.Among those,osteogenic differentiation of MSCs has been widely explored in many bone tissue engi... Mesenchymal stem cells(MSCs)can differentiate into various tissue cell types including bone,adipose,cartilage,and muscle.Among those,osteogenic differentiation of MSCs has been widely explored in many bone tissue engineering studies.Moreover,the conditions and methods of inducing osteogenic differentiation of MSCs are continuously advancing.Recently,with the gra-dual recognition of adipokines,the research on their involvement in different pathophysiological processes of the body is also deepening including lipid metabolism,inflammation,immune regulation,energy disorders,and bone homeostasis.At the same time,the role of adipokines in the osteogenic differentiation of MSCs has been gradually described more completely.Therefore,this paper reviewed the evidence of the role of adipokines in the osteogenic differentiation of MSCs,emphasizing bone formation and bone regeneration. 展开更多
关键词 Mesenchymal stem cells Adipokines Adipose tissue Osteogenic differentiation Osteogenesis Bone regeneration
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Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes 认领 引用 被引量：3
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作者 Olusola Olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu +2 位作者 Jean Paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo 《World Journal of Diabetes》 SCIE 2017年第7期337-345,共9页
Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adi... Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents. 展开更多
关键词 Adipokines Adipose tissue Insulin resistance Antidiabetic Obesity
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Exercise training modulates adipokine dysregulations in metabolic syndrome 认领 引用 被引量：7
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作者 Parvin Babaei Rastegar Hoseini 《Sports Medicine and Health Science》 2022年第1期18-28,共11页
Metabolic syndrome(MetS)is a cluster of risk factors for various metabolic diseases,and it is characterized by central obesity,dyslipidemia,hypertension,and insulin resistance.The core component for MetS is adipose ti... Metabolic syndrome(MetS)is a cluster of risk factors for various metabolic diseases,and it is characterized by central obesity,dyslipidemia,hypertension,and insulin resistance.The core component for MetS is adipose tissue,which releases adipokines and influences physical health.Adipokines consist of pro and anti-inflammatory cytokines and contribute to various physiological functions.Generally,a sedentary lifestyle promotes fat accumulation and secretion of pro-inflammatory adipokines.However,regular exercise has been known to exert various beneficial effects on metabolic and cognitive disorders.Although the mechanisms underlying exercise beneficial effects in MetS are not fully understood,changes in energy expenditure,fat accumulation,circulatory level of myokines,and adipokines might be involved.This review article focuses on some of the selected adipokines in MetS,and their responses to exercise training considering possible mechanisms. 展开更多
关键词 Adipokines Insulin resistance Aerobic training Resistance training Metabolic syndrome
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Pharmacological effects of lipid-lowering drugs on circulating adipokines 认领 引用 被引量：5
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作者 Desiree Wanders Eric P Plaisance Robert L Judd 《World Journal of Diabetes》 2010年第4期116-128,共13页
The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis ... The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids)on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4)and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-αdemonstrate that these agents have little effect on circulating TNF-αconcentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. 展开更多
关键词 Statins Fibrates Niacin Omega-3 fatty acids Adipokines Leptin Adiponectin Cardiovascular disease Hyperlipidemia
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Adipokines as a novel link between obesity and atherosclerosis 认领 引用 被引量：3
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作者 Hye Jin Yoo Kyung Mook Choi 《World Journal of Diabetes》 2014年第3期357-363,共7页
The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pa... The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pathogenesis of obesity-related metabolic disturbances. Obesity is a well-known risk factor for atherosclerosis, and accelerates atherosclerosis by many mechanisms such as increase in blood pressure and glucose level, abnormal lipid profiles, and systemic inflammation. Furthermore, growing evidence suggests that some adipokines directly mediate the process of atherosclerosis by influencing the function of endothelial cells, arterial smooth muscle cells, and macrophages in vessel walls. In obese patients, the secretion and coordination of such adipokines is abnormal, and the secretion of specific adipokines increases or decreases. Accordingly, the discovery of new adipokines and elucidation of their functions might lead to a new treatment strategy for metabolic disorders related to obesity, including cardiovascular diseases. 展开更多
关键词 Adipose tissue Adipokine Obesity Atherosclerosis Inflammation
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Adipokine在肥胖症及胰岛素抵抗中的作用(综述) 认领 引用 被引量：3
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作者 李娟 沈飞 陈巍 《河北科技师范学院学报》 CAS 2011年第2期75-80,共6页
从Adipokines与胰岛素抵抗的关系,Adipokines与肥胖者脂肪组织巨噬细胞浸润,炎症与胰岛素抵抗信号转导,内质网应激与胰岛素抵抗等方面综述了Adipokines在肥胖症及胰岛素抵抗中的作用;并着重探讨了肥胖,adipokines,炎症,胰岛素抵抗四者... 从Adipokines与胰岛素抵抗的关系,Adipokines与肥胖者脂肪组织巨噬细胞浸润,炎症与胰岛素抵抗信号转导,内质网应激与胰岛素抵抗等方面综述了Adipokines在肥胖症及胰岛素抵抗中的作用;并着重探讨了肥胖,adipokines,炎症,胰岛素抵抗四者之间的关系。 展开更多
关键词 Adipokine 肥胖症 胰岛素抵抗
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