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Adipose-derived mesenchymal stem cells from solid tissue and lipoaspirates:A comparative study of phenotype,growth,and secretome 认领 引用 被引量：1
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作者 Phuong Thi Minh Dam Dai Dang Nguyen +7 位作者 Anh Thi Thu Ngo Anh Minh Tran Truc Thanh Nguyen Phong Van Nguyen Chi Quynh Nguyen Anh Thi Tuyet Nguyen Quynh-Trang Thi Pham Uyen Thi Trang Than 《World Journal of Stem Cells》 SCIE 2026年第1期36-48,共13页
BACKGROUND Mesenchymal stem cells(MSCs)are considered a promising therapy for various diseases due to their strong potential in regenerative medicine and immunomodulation.The tissue source of MSCs has gained attention... BACKGROUND Mesenchymal stem cells(MSCs)are considered a promising therapy for various diseases due to their strong potential in regenerative medicine and immunomodulation.The tissue source of MSCs has gained attention for its role in influencing their function,accessibility,and readiness for clinical use.AIM To identify the most suitable adipose source for MSC isolation and expansion for further applications.METHODS We isolated MSCs from solid adipose tissue and liposuction aspirates using the enzyme method.The MSCs were examined for their expansion using population doubling time,differentiation capacity using multilineage differentiation induction,surface markers using flow cytometry,and stability of chromosomes using the karyotyping method.Growth factors and cytokines in MSC-conditioned media were analyzed using the Luminex assay.RESULTS MSCs were isolated from solid adipose tissue and lipoaspirates and expanded from passage 0 to passage 2.All adipose-derived MSCs(AD-MSCs)exhibited the typical elongated,spindle-shaped morphology and comparable proliferation rate.They expressed positive surface markers(cluster of differentiation 73[CD73]:>97%,CD90:>98%,and CD105:>95%),and negative markers(<1%).All MSCs expressed similar levels of stemness genes(octamer-binding transcription factor 4,SRY-box 2,Krüppel-like factor,and MYC),colonyforming,and trilineage differentiation potential.Karyotyping analysis revealed normal chromosomal patterns in all samples,except one sample exhibiting a polymorphism(1qh+).Furthermore,the growth factors and cytokines of hepatocyte growth factor,vascular endothelial growth factor A,interleukin 6(IL-6),and IL-8 were detected in all AD-MSC conditioned media;but fibroblast growth factor-2 and keratinocyte growth factor were selectively expressed in conditioned media from solid or lipoaspirate AD-MSCs,respectively.CONCLUSION These findings indicate that AD-MSCs from both adipose sources possess all of the characteristic features of MSCs with source-specific secretome differences,which are suitable for further expansion and various clinical applications. 展开更多
关键词 Adipose-derived mesenchymal stem cells Adipose tissues Liposuction aspirates Multilineage differentiation Colony-forming units
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Maximizing pediatric stem cell harvest:A novel two-step digestion approach for adipose tissue 认领 引用
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作者 Asad Mushtaq Mahmood S Choudhery +2 位作者 Taqdees Arif Ahmad Niaz Asim Pervaiz 《World Journal of Stem Cells》 SCIE 2026年第3期131-143,共13页
BACKGROUND Stromal vascular fraction(SVF)derived from adipose tissue(AT)is a heterogeneous cell mixture.SVF is commonly prepared via enzymatic digestion of AT.Typically,only the initial SVF(SVF1)is harvested,and the r... BACKGROUND Stromal vascular fraction(SVF)derived from adipose tissue(AT)is a heterogeneous cell mixture.SVF is commonly prepared via enzymatic digestion of AT.Typically,only the initial SVF(SVF1)is harvested,and the remaining AT is discarded.However,residual AT may contain viable regenerative cells.AIM To explore a novel approach involving a second enzymatic digestion to maximize stem cell yield,particularly relevant for pediatric patients or those with limited adipose reserves.METHODS AT samples obtained via liposuction were digested twice using collagenase type Ⅳ to yield SVF1 and SVF2(after 1st and 2nd digestions,respectively).Both fractions were assessed for cell viability,mononuclear cell count,plating efficiency,and the expression of surface markers via flow cytometry.Gene expression analysis of vascular endothelial growth factor,stromal cell-derived factor,nitric oxide synthase-3,CD14,matrix metalloproteinase 3,interleukin-4 receptor,P16,and P53 was performed using quantitative reverse transcription polymerase chain reaction.Histology was performed on AT samples to assess structural integrity and cellular composition across different digestion stages.RESULTS Results demonstrated that SVF2 contained a significant number of mononuclear cells and exhibited a high plating efficiency.Flow cytometry and gene expression analyses further confirmed that SVF2 retained regenerative cells.Furthermore,histological evaluation using hematoxylin and eosin staining revealed the presence of intact cells within the residual tissue post-first digestion.CONCLUSION In conclusion,secondary digestion of AT(typically discarded after 1st digestion),can yield additional regenerative cells.This method enhances stem cell number for stem cell-based therapies and is particularly valuable for pediatric patients and those with low-AT reserves. 展开更多
关键词 Stromal vascular fraction Adipose tissue derived stem cells Adipose tissue Regenerative medicine Two-step digestion approach
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Adipose-derived mesenchymal stem cells:Source-dependent heterogeneity,translational challenges,and emerging precision strategies 认领 引用
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作者 Qing Xu Huan Li +1 位作者 Jian-Chuan Deng Nan Zhang 《World Journal of Stem Cells》 SCIE 2026年第4期1-11,共11页
Adipose-derived mesenchymal stem cells(ADSCs)have emerged as an important cell source in regenerative medicine because of their accessibility,abundance,multilineage differentiation potential,and paracrine activity.How... Adipose-derived mesenchymal stem cells(ADSCs)have emerged as an important cell source in regenerative medicine because of their accessibility,abundance,multilineage differentiation potential,and paracrine activity.However,ADSCs are not biologically uniform,and their properties are strongly influenced by donor-related factors,anatomical origin of adipose tissue,and technical procedures used for cell isolation,expansion,and characterization.This review summarizes current advances in defining the source-dependent characteristics of ADSCs,with particular emphasis on donor age,metabolic status,adipose depot specificity,isolation methods,culture conditions,and source-related molecular and functional heterogeneity.Evidence from transcriptomic,epigenetic,immunophenotypic,and secretome studies indicates that ADSCs from different sources may differ substantially in proliferation and differentiation capacity,immunomodulatory activity,and therapeutic performance.Major challenges remain in translating these findings into clinical practice,including donor variability,inconsistent manufacturing workflows,lack of standardized potency assays,and insufficient integration of source-stratified strategies into product development.Emerging directions such as single-cell and multi-omics profiling,cell-free secretome-based therapeutics,and source-aware manufacturing frameworks may improve precision and reproducibility in ADSC-based therapies.A clearer understanding of ADSC source dependency will be essential for optimizing donor selection,improving product consistency,and advancing the safe and effective clinical translation of regenerative medicine applications. 展开更多
关键词 Adipose-derived mesenchymal stem cells Source dependency Donor heterogeneity Adipose tissue depot Secretome Regenerative medicine
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Hesperidin alleviates systemic inflammation and oxidative stress by remodeling adipose tissue lipid metabolism in periparturient dairy cows 认领 引用
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作者 Jian Tan Ying Wang +3 位作者 Haoyu Niu Luoyun Fang Yuchao Zhao Linshu Jiang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第3期1486-1514,共29页
Background Periparturient dairy cows experience a pronounced negative energy balance that accelerates adipose tissue lipolysis and predisposes them to oxidative stress and inflammation.Plant flavonoids such as hesperi... Background Periparturient dairy cows experience a pronounced negative energy balance that accelerates adipose tissue lipolysis and predisposes them to oxidative stress and inflammation.Plant flavonoids such as hesperidin are known for their antioxidant and immunomodulatory properties,yet their specific actions on adipose tissue metabolism during the transition period remain unclear.This study evaluated whether dietary hesperidin improves milk composition and systemic metabolic health while remodeling adipose tissue lipid metabolism in periparturient cows.Results Hesperidin supplementation enhanced milk composition by increasing protein concentration and yield and lowering milk urea nitrogen,while dry matter intake and milk production were unaffected.In serum,hesperidin reduced non-esterified fatty acid,β-hydroxybutyrate,glucose,and insulin,and elevated adiponectin,leading to improved insulin sensitivity.Antioxidant capacity was strengthened,and several proinflammatory mediators,including IL-18,TNF-α,serum amyloid A,lipopolysaccharide-binding protein,caspase-1,and ASC,were significantly reduced.Three HES-derived metabolites(hesperetin-7-O-glucuronide,hesperetin,and hesperetin-7-O-sulfate)in serum and adipose tissue were detected.In adipose tissue,hesperidin increased total antioxidant capacity and superoxide dismutase activity and downregulated IL-18,NLRP3,and ASC,while adiponectin was elevated,indicating enhanced redox defenses and reduced inflammasome activation.Multi-omics analyses revealed consistent remodeling of adipose metabolism.Metabolomics and lipidomics showed decreased ceramides and acylcarnitines,together with increased sphingomyelins and glycerophospholipids,patterns that were also evident in serum lipid profiles.Proteomics further supported these findings by indicating upregulation of pathways related to fatty acid oxidation,mitochondrial function,and phospholipid and glutathione metabolism,alongside suppression of sphingolipid and innate immune signaling.Conclusions Dietary hesperidin improved milk protein output and systemic metabolic health,enhanced antioxidant capacity,and alleviated inflammatory responses during the transition period.Integrated omics evidence indicates that hesperidin reprograms adipose lipid metabolism—particularly sphingolipid pathways—toward lower ceramide burden and higher sphingomyelin,while reinforcing mitochondrial and antioxidant functions.These adaptations dietary supplementation with hesperidin on serum acute phase protein in periparturient cows.Additional file 4:Table S3.Differential metabolites in adipose tissue samples between CON and HES cows.Additional file 5:Fig.S4.Lipid classification in adipose tissue and serum.Additional file 6:Table S4.Differential lipid species in adipose tissue samples between CON and HES cows.Additional file 7:Fig.S5.Proteomic overview of adipose tissue in control(CON)and hesperidin(HES)cows.Additional file 8:Table S5.Differentially expressed proteins in adipose tissue of dairy cows.Additional file 9:Table S6.Differential lipid species in serum samples between CON and HES cows. 展开更多
关键词 Adipose tissue Ceramides Hesperidin Lipidomics Periparturient dairy cows Sphingolipid metabolism
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Fucosylated IgG Contributes to Adipose Tissue Dysfunction During Aging 认领 引用
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作者 Jingyu Wang Wei Su +3 位作者 Haotian Wang Licui Liu Jinlong Li Youxin Wang 《Engineering》 SCIE EI CSCD 2026年第2期149-158,共10页
Immunoglobulin G(IgG)is recognized as a key regulator of metabolic dysfunction and fibrosis in adipose tissue,and its functional properties are tightly regulated by its glycosylation profile.However,the role of Ig G g... Immunoglobulin G(IgG)is recognized as a key regulator of metabolic dysfunction and fibrosis in adipose tissue,and its functional properties are tightly regulated by its glycosylation profile.However,the role of Ig G glycosylation in adipose aging remains unclear.Here,we performed transcriptomic and glycoproteomic analyses of epididymal white adipose tissue(eWAT)from young and aged mice.RNA sequencing(RNA-seq)analysis revealed a significant downregulation of adipogenic genes in aged eWAT,accompanied by elevated expression levels of inflammatory and fibrotic markers,which were further validated by quantitative polymerase chain reaction(qPCR).N-and O-glycoproteomic analyses revealed widespread changes in glycosylation.Differentially glycosylated proteins are primarily localized to the extracellular space and participate in innate immune responses,transport and signal transduction,extracellular matrix(ECM)–receptor interaction pathways,and so on.Notably,IgG glycosylation levels were significantly increased in aged mice.Specifically,the N-fucosylation of IgG1,IgG2a,and IgG3 was elevated by 3.1-,10.4-,and 3.2-fold,respectively,while only IgG2a showed increased O-fucosylation.These findings suggest that N-fucosylation is a common age-related modification across IgG subtypes.Using in vivo models,we further demonstrated that B-cell depletion-induced IgG reduction increased adipogenic and inflammatory gene expression,while the expression of fibrotic markers was suppressed.These effects were reversed upon repletion with either fucosylated or nonfucosylated IgG.Importantly,compared with nonfucosylated IgG,fucosylated IgG exacerbated inflammation and fibrosis but inhibited adipogenesis more strongly.Taken together,our results identify fucosylated IgG as a key mediator of adipose dysfunction during aging and suggest that modulating IgG fucosylation may offer therapeutic potential for age-related metabolic disorders. 展开更多
关键词 Immunoglobulin G Fucosylation Adipose tissue aging Glycosylation Metabolic dysfunction Fibrosis
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Integrated multi-omics analysis reveals component differences and their regulatory mechanisms of adipose tissue as lard raw material between Bamei and Large White pigs 认领 引用
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作者 Rui Li Haozhe Han +6 位作者 Zihang Tie Ran Wu Mengmeng Bai Mingyu Wang Gongshe Yang Weijun Pang Rui Cai 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期763-777,共15页
Bamei pigs,an indigenous Chinese breed,yield meat with a delectable flavor and boast higher carcass fat content compared to commercial breeds,making them a rich food source for humans.However,the differences in lipid ... Bamei pigs,an indigenous Chinese breed,yield meat with a delectable flavor and boast higher carcass fat content compared to commercial breeds,making them a rich food source for humans.However,the differences in lipid and nutrient components between the adipose tissue of Bamei pigs and commercial pigs are still unclear.The study employed UPLC-MS/MS to quantify the composition of lipids and metabolites in the backfat of both Bamei and Large White pigs.A total of 428 lipids and 193 metabolites were significantly different between the 2 groups.Specifically,Bamei pig backfat exhibited altered levels of various lipids and metabolites that may potentially contribute to nutritional and flavor differences,including unsaturated triglycerides,free fatty acids,medium-chain triglycerides,essential amino acids,vitamins and antioxidants,while maintaining reduced cholesterol levels.Furthermore,we delved into the molecular mechanisms underlying these nutritional differences by analyzing significantly different 431 m RNAs and 865 proteins and integrating the regulatory network of protein-metabolite-lipid pathway.Importantly,in the pyruvate metabolic pathway of Bamei pigs,the bioprocess of lactate production was inhibited but the acetyl-Co A production was activated,suggesting the possibility that energy allocation favors the biogenesis of lipid precursors.These findings may contribute to guiding industrial food producers in enhancing the quality of lard at the genetic and molecular levels. 展开更多
关键词 Bamei pig Adipose tissue Multi-omics Pyruvate metabolism
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Phenotypic profiling and characterization of stromal vascular fraction using two Novel adipose tissue processing systems 认领 引用
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作者 Fabio Valerio Sciarretta Vittorio Appierto +2 位作者 Silvana Campisi Naveen Jeyaraman Madhan Jeyaraman 《World Journal of Translational Medicine》 2026年第2期87-97,共11页
BACKGROUND Adipose-derived stromal cells(ADSCs)are a mixed cell population,which includes,amongst others,mesenchymal stromal cells(MSCs).The first choice of cell isolation is subcutaneous adipose tissue as it is easil... BACKGROUND Adipose-derived stromal cells(ADSCs)are a mixed cell population,which includes,amongst others,mesenchymal stromal cells(MSCs).The first choice of cell isolation is subcutaneous adipose tissue as it is easily accessible,abundant and easily harvested by a less invasive procedure.AIM To determine the viability and phenotypic properties of the ADSCs that are treated by two procedures to induce stromal vascular fraction(SVF)by lipoaspirate,to verify that they can be used to ensure safe and efficient repair of articular cartilage defects.METHODS Lipoaspirate samples of adipose tissues were taken using various commercially available systems of withdrawal.The cellular components of SFVs in untreated lipoaspirate samples were compared with similar cells obtained with the use of lipoaspirate samples treated with Lipogems®and Body-Jet®eco systems as a method of assessing cell composition and viability.The multicolour flow cytometry(FC)analysis was used to characterize the outputs.RESULTS Multicolour FC analysis revealed that SVF is composed of heterogeneous cell populations such as:(1)Adipose stem cells(CD45-CD90+CD73+CD34+CD31-CD105-CD146-);(2)Endothelial progenitor cells(CD45-CD90+CD73+CD34+CD31+CD105 LowCD146+);and(3)Pericytes(CD45-CD90+CD73+CD34-CD31-CD105-CD146+),and other more or less characterized cells.The overall cell viability was similar across the groups.However,we observed a steady rise in the percentage of the endothelial cells and pericytes in the processed samples with Lipogems®and Body-Jet®eco systems in comparison to the untreated lipoaspirate samples.CONCLUSION Phenotypic characterization studies have suggested that MSC populations are found in a perivascular site with ADSCs shared with pericytes and endothelial cells.We have indications that the mechanical withdrawal steps can leave a large population heterogeneity of cells,retaining a more intricate tissue architecture(niche). 展开更多
关键词 Adipose tissue Adipose-derived stromal cells Mesenchymal stromal cells Pericytes Flow cytometry Cartilage regeneration
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Schwann song of neurogenic mesenchymal stem cells:Identifying an alternative neural progenitor in adipose and bone marrow 认领 引用
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作者 Rhian Stavely Leah C.Ott 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3539-3540,共2页
Multipotent stromal cells,otherwise known as mesenchymal stem cells(MSCs),have been widely studied for their regenerative potential across multiple tissues,including the nervous system(Caplan,2017).Reports suggesting ... Multipotent stromal cells,otherwise known as mesenchymal stem cells(MSCs),have been widely studied for their regenerative potential across multiple tissues,including the nervous system(Caplan,2017).Reports suggesting that MSCs can differentiate into neurons and glia spurred optimism towards their future therapeutic application in nervous system disorders.Despite extensive research,however,the precise cellular mechanisms underlying their neural differentiation potential are unclear(George et al.,2019). 展开更多
关键词 multipotent stromal cellsotherwise mesenchymal stem cells mscs mesenchymal stem cells regenerative potential bone marrow multipotent stromal cells cellular mechanisms neural differentiation adipose multipotent stromal cells
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Effects and mechanisms of adipose tissue-derived extracellular vesicles in vascular inflammation and dysfunction 认领 引用 被引量：1
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作者 Daphne Lintsen Bieke Broux 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2005-2006,共2页
Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated ... Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated to neuroinflammation,such as Alzheimer's disease,it is now shown to precede pathological protein aggregations. 展开更多
关键词 pathological protein aggregations vascular inflammation neuroinflammation neurodegenerative diseasessuch multiple sclerosis Alzheimers disease adipose tissue derived extracellular vesicles alzheimers diseaseit
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Tributyltin-dysregulated periprostatic adipose tissue enhances prostate cell survival and migration,implicating the C-C motif chemokine receptor 3 认领 引用
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作者 Mariana Feijó César R.Casanova +7 位作者 Lara R.S.Fonseca Marília I.Figueira Luís A.Brás Gonçalo Catarro Eugenia Gallardo Endre Kiss-Toth Sara Correia Sílvia Socorro 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期225-238,共14页
Obesity-dysregulated periprostatic adipose tissue(PPAT)has been implicated in the aggressiveness of prostate cancer(PCa).On the other hand,obesity has been linked to environmental influences,namely,the endocrine-disru... Obesity-dysregulated periprostatic adipose tissue(PPAT)has been implicated in the aggressiveness of prostate cancer(PCa).On the other hand,obesity has been linked to environmental influences,namely,the endocrine-disrupting chemicals capable of promoting adipogenesis and fat accumulation(obesogens).However,it is unknown whether obesogens can induce PPAT dysfunction,disrupting its crosstalk with PCa cells.The present study hypothesises that obesogens can target the PPAT,affecting its secretory activity and contributing to the development or aggressiveness of PCa.Through in vivo,ex vivo approaches and conditioned medium(CM)assays,we demonstrated that exposure to tributyltin(TBT),the first described obesogen,induced a PPAT"obese"phenotype,with adipocyte enlargement and enhanced secretion of leptin and C-C motif chemokine ligand 7(CCL7).TBT-PPAT altered prostate cell fate,enhancing their viability,proliferation and migration,and reducing apoptotic rate.Moreover,it was shown that the TBT-PPAT secretome promoted the migration of prostate cells involving the C-C motif chemokine receptor 3(CCR3).Overall,this study demonstrated the biological significance of TBT exposure,bringing functional evidence on the contribution of PPAT obesogenic dysregulation to prostate carcinogenesis.Moreover,it highlights the differences that may exist in PCa monitoring and treatment in obese vs.lean patients,pointing out the modulation of PPAT activity as a therapeutic target. 展开更多
关键词 C-C motif chemokine receptor 3 Obesity Obesogens Periprostatic adipose tissue Prostate cancer Tributyltin
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Exosomes derived from kiwifruit increase the mitochondrial function of browning adipose tissue and exert anti-obesity activity 认领 引用
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作者 Chengxun He Xiaohui Guo +4 位作者 Die Qian Juan Guo Hong Zhang Li Ai Wei Jin 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3181-3194,共14页
Obesity has become a global health problem and has received much attention worldwide.Promoting or increasing the energy expenditure function of browning adipose tissue(BAT)is believed to be an effective strategy for t... Obesity has become a global health problem and has received much attention worldwide.Promoting or increasing the energy expenditure function of browning adipose tissue(BAT)is believed to be an effective strategy for treating obesity.Exosome-like nanovesicles(EMs)derived from plants are considered important natural active substances with various pharmacological activities.Furthermore,EMs are safe,biocompatible and biodegradable and are easy to prepare in large quantities.In this study,EMs of kiwifruit(Actinidia chinensis)(KEMs)were successfully extracted and showed significant anti-obesity activity.Further study revealed that KEM treatment inhibited the degeneration of BAT and increased the expression of the uncoupling protein(UCP)1 protein and genes in obese mice.In addition,on the basis of in vivo and in vitro experiments,we also found that KEMs increased the function and contents of mitochondria in BAT.These results indicate that KEMs can suppress BAT degradation caused by obesity and increase energy consumption in obese mice to exert anti-obesity effects.Finally,no obvious toxicity to the liver,kidneys,heart,spleen or lungs was observed in KEM-treated mice in vivo.Overall,this study is the first report regarding the anti-obesity activity of KEMs,which is a potential natural treatment for obesity with high safety. 展开更多
关键词 Browning adipose tissue Uncoupling protein 1 Obesity Exosome-like nanovesicles Kiwifruit(Actinidia chinensis)
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Adipose tissue-brain crosstalk in comorbid obesity and traumatic brain injury:Insights into mechanisms 认领 引用
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作者 Susan C.Burke Bogdan A.Stoica Rebecca J.Henry 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1989-1990,共2页
Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated... Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated with increased levels of circulato ry pro-inflammatory marke rs up to 1 year postTBI(Eagle et al.,2023). 展开更多
关键词 pro inflammatory markers comorbid obesity adipose tissue rehabilitation outcomes traumatic brain injury tbi exhibit traumatic brain injury brain crosstalk
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Coronary computed tomography angiography adipose tissue attenuation in diabetic patients with myocardial ischemia and nonobstructive coronary arteries 认领 引用
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作者 Kai-Xiang Su Si-Yu Jiang +5 位作者 Cai-Feng Pang Fan Yang Yu-Qing Tang Xiao-Gang Li Wen-Feng He Rui Li 《World Journal of Cardiology》 2026年第1期133-144,共12页
BACKGROUND Type 2 diabetes mellitus(T2DM)substantially increases the risk of cardiovascular disease,including ischemia with non-obstructive coronary artery disease(INOCA).Coronary computed tomography angiography(CCTA)... BACKGROUND Type 2 diabetes mellitus(T2DM)substantially increases the risk of cardiovascular disease,including ischemia with non-obstructive coronary artery disease(INOCA).Coronary computed tomography angiography(CCTA)enables early detection of coronary abnormalities;however,it may fail to identify INOCA due to the absence of overt stenosis.Pericoronary adipose tissue attenuation(PCATa)values derived from CCTA in the proximal segments of the left anterior descending(LAD),left circumflex(LCX),and right coronary artery(RCA)serve as effective imaging biomarkers for coronary inflammation.However,its clinical use for identifying INOCA in patients with T2DM remains poorly defined.AIM To investigate PCATa differences and their diagnostic value for identifying INOCA in patients with T2DM.METHODS This retrospective study involved 228 T2DM patients underwent CCTA and 120 healthy individuals.The mean PCATa values within the proximal segments of the three major coronary arteries were compared between groups.Further subgroup analysis was performed to assess the differences in PCTAa and clinical characteristics between T2DM patients with and without INOCA.Logistic regression analysis was conducted to identify the independent risk factors for INOCA,and the receiver operating characteristic curves were generated to evaluate the diagnostic performance of each indicator.RESULTS Compared with controls,T2DM patients exhibited significantly higher PCATa values in all three major coronary arteries.Among them,those with concomitant INOCA showed further increases compared to those without INOCA(all P<0.05).Multivariate logistic regression identified age;female sex;elevated glycated hemoglobin;and increased PCATa in the LAD,LCX,and RCA as independent risk factors for INOCA.Receiver operating characteristic analysis showed good diagnostic performance for PCATa[LAD area under the curve(AUC)=0.809;LCX AUC=0.777;RCA AUC=0.758],outperforming traditional clinical indicators(AUC=0.731).Combining PCATa with clinical parameters yielded the highest diagnostic accuracy(LAD AUC=0.851;LCX AUC=0.842;RCA AUC=0.841).CONCLUSION Elevated proximal PCATa is an independent risk factor for INOCA in T2DM.Combining PCATa with clinical data improves diagnostic performance in this population. 展开更多
关键词 Type 2 diabetes mellitus Ischemia with non-obstructive coronary arteries Pericoronary adipose tissue attenuation index Coronary computed tomography angiography Coronary artery disease
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Multiscale regulatory network underlying cold exposure-induced adipose tissue remodeling:Microscopic and macroscopic perspectives 认领 引用
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作者 Yusha Yang Guanyu Zhang +1 位作者 Xi Li Danfeng Yang 《Frigid Zone Medicine》 2026年第1期56-64,共9页
Cold exposure,a prototypical environmental stressor,activates the metabolic plasticity of adipose tissue(AT)by inducing extensive AT remodeling.This adaptive process not only enhances cold tolerance but also criticall... Cold exposure,a prototypical environmental stressor,activates the metabolic plasticity of adipose tissue(AT)by inducing extensive AT remodeling.This adaptive process not only enhances cold tolerance but also critically improves glucose and lipid(glucolipid)metabolic homeostasis through systemic metabolic reprogramming.This review synthesizes recent high-resolution sequencing studies to comprehensively examine three core dimensions of cold exposure-induced AT remodeling:tissue phenotype,cellular architecture,and metabolic function.In addition,it elucidates intercellular communication and inter-organ interactions within the multiscale regulatory networks that govern AT remodeling,thereby providing a theoretical framework for the development of intervention strategies for metabolic diseases based on mechanisms of cold-induced AT remodeling. 展开更多
关键词 cold exposure adipose tissue plasticity metabolic reprogramming intercellular communication inter-organ regulatory networks
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Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation 认领 引用 被引量：1
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作者 Bichen Zhao Ming Li +7 位作者 Huijing Zhang Renxu Chang Jingyi Wang Wanli Zhao Yue Yang Muhammad Usman Juan J.Loor Chuang Xu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第6期2768-2781,共14页
Background Sustained lipolysis exacerbates subclinical ketosis(SCK)in dairy cows and is associated with inflammation and adipose tissue macrophage(ATM)infiltration.While ATM involvement in adipose homeostasis and infl... Background Sustained lipolysis exacerbates subclinical ketosis(SCK)in dairy cows and is associated with inflammation and adipose tissue macrophage(ATM)infiltration.While ATM involvement in adipose homeostasis and inflammation in early lactation is recognized,a comprehensive exploration of ATM polarization phenotypes in SCK cows is lacking.This study aimed to characterize ATM polarization and its link to lipolysis and inflammation in SCK cows.Results Subcutaneous adipose tissue samples were obtained from dairy cows to analyze protein expression and gene profiles.Compared with healthy cows,SCK cows had higher serum BHBA and NEFA,smaller adipocytes,and increased expression of lipolytic enzymes(LIPE,ATGL),indicating enhanced lipolysis.Decreased levels of FASN,PPARγ,p-SMAD3,and TGFβsuggested impaired adipogenesis.Inflammatory markers(TNF-α,IFN-γ,TLR4,Caspase1)and NFκB signaling activity were elevated.ATM infiltration was supported by increased CD9,CD68,TREM2,and CXCL1 expression.Protein abundance of M1 polarization markers(iNOS,CD86 and CCL2)in ATMs were associated with greater levels of NOS2,IL1B,CD86 and CCL2 mRNA expression in SCK cows;fluorescence intensity of NOS2 and CD86 also was elevated,alongside a higher proportion of CD68+/CD86+immunopositive cells within adipose tissue.ELISA further quantified increased concentrations of IL-1β and CCL2.Conversely,the abundance of ATM M2 polarization markers,including CD206,IL-10,KLF4,and Arg1,at both the protein and mRNA levels demonstrated a decline.Meanwhile,the proportion of CD68+/CD206+immune response cells was relatively low in SCK cows.Conclusions Overall,the present study indicated an augmented macrophage presence within adipose tissue during subclinical ketosis,with a predominance of pro-inflammatory macrophages(M1 ATM).This observation suggested a vicious cycle wherein macrophage infiltration and pro-inflammatory polarization coincide with enhanced lipolysis and an amplified inflammatory cascade. 展开更多
关键词 Adipose tissue macrophages Adipose tissue remodeling Macrophage polarization Subclinical ketosis
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Adipose tissue as a living drug:Stromal vascular fraction and adipose tissue-derived stem cells in regenerative medicine 认领 引用 被引量：1
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作者 Mahmood S Choudhery Ahmad Niaz +1 位作者 Taqdees Arif Ruhma Mahmood 《World Journal of Stem Cells》 SCIE 2025年第12期46-64,共19页
Adipose tissue has emerged as a rich and clinically relevant source of regenerative cells.It offers a minimally invasive,abundant,and autologous reservoir for therapeutic applications.Among its cellular components,the... Adipose tissue has emerged as a rich and clinically relevant source of regenerative cells.It offers a minimally invasive,abundant,and autologous reservoir for therapeutic applications.Among its cellular components,the stromal vascular fraction(SVF)and adipose-derived stem cells(ASCs)have gained considerable attention due to their potent regenerative and immunomodulatory capacities.SVF is a heterogeneous mixture of cells,whereas ASCs constitute a more homogeneous mesenchymal stem cell-like population obtained through in vitro expansion.Together,these cell populations(SVF and ASCs)are described as“living drugs”,as they are viable and act as dynamic biological agents within the body.Unlike conventional medicines,living drugs exert therapeutic effects not only through direct differentiation but also via the secretion of bioactive molecules,including cytokines,growth factors,and extracellular vesicles.These secreted factors can modulate the surrounding microenvironment,enhance tissue repair,and regulate immune responses.Such paracrine mechanisms often play a more significant role than direct cell replacement,making living drugs versatile tools for regenerative medicine.This review provides a comprehensive overview of SVF and ASCs as living drugs.It discusses their cellular composition,mechanisms of action,methods of isolation,and the regenerative biomolecules they secrete.Furthermore,it explores current and emerging clinical applications,challenges,and future innovations. 展开更多
关键词 Living drugs Adipose tissue Stromal vascular fraction Regenerative medicine Biomolecules Adipose tissue derived stem cells
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Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1 认领 引用 被引量：2
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作者 Qing Zhang Chengxun He +5 位作者 Juan Guo Dandan Tang Die Qian Chuan Zheng Chunjie Wu Wei Peng 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2025年第2期288-309,I0005-I0011,共22页
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy... Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxylum bungeanum,which promotes the management of obesity by triggering the browning of white adipose tissue(WAT)targeting the membrane receptor of transient receptor potential vanilloid 1(TRPV1).However,HAS easily undergoes configuration transformation and oxidative degradation.The short peptide CKGGRAKDC or adipose-targeting sequence(ATS)binds specifically to prohibitin on the surface of WAT cells and can be used as recognition assembly to enhance adipocyte targetability.Furthermore,mesoporous silica nanoparticles(MSNs)are widely used in drug delivery systems because of their large specific surface area and pore volume.Therefore,HAS-loaded adipose-targeted MSNs(MSNs-ATS)were developed to enhance the adipocyte targetability,safety,and efficacy of HAS,and tested on mature 3T3-L1 cells and obese mouse models.MSNs-ATS showed higher specificity for adipocyte targetability without obvious toxicity.HAS-loaded MSNs-ATS showed anti-obesity effects superior to those of HAS alone.In conclusion,we successfully developed adipocyte-targeted,HAS-loaded MSNs with good safety and anti-obesity effects. 展开更多
关键词 Hydroxy-α-sanshool Adipocyte targetability Mesoporous silica nanoparticles White adipose tissue browning Obesity
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Direct Differentiation of Human Adult Adipose Tissue into Multilineage Functional Organoids 认领 引用 被引量：1
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作者 Ru-Lin Huang Jing Yang +10 位作者 Yuxin Yan Xiangqi Liu Xiya Yin Chuanqi Liu Xingran Liu Rehanguli Aimaier Qiumei Ji Gen Li Tao Zan Kang Zhang Qingfeng Li 《Engineering》 SCIE EI CSCD 2025年第10期286-300,共15页
Current organoid-generation strategies rely predominantly on intricate in vitro manipulations of dissociated stem cells,including isolation,expansion,and genetic modification.However,these approaches present significa... Current organoid-generation strategies rely predominantly on intricate in vitro manipulations of dissociated stem cells,including isolation,expansion,and genetic modification.However,these approaches present significant challenges in terms of safety and scalability for clinical applications.An alternative strategy involves the direct generation of organoids from readily available tissues.Herein,we report the generation of functional organoids representing all three germ layers from human adult adipose tissue without single-cell processing steps.Specifically,by employing a specialized suspension culture system,we have developed reaggregated microfat(RMF)tissues,which differentiated into mesodermal bone marrow organoids capable of reconstituting human normal hematopoiesis in immunodeficient mice,endodermal insulin-producing organoids that reversed hyperglycemia in streptozotocin(STZ)-induced diabetic mice,and ectodermal nervous-like tissues resembling neurons and neuroglial cells.These findings therefore highlight the potential of human adipose tissue as a safe,scalable,and clinically viable source for organoid-based regenerative therapies. 展开更多
关键词 Tissue regeneration Regenerative medicine Human adipose tissue Islet organoids Bone marrow organoids Neuroectoderm differentiation Stem cells
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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats 认领 引用 被引量：1
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作者 Manman Li Nange Ma +12 位作者 Shujie Luo Yuyi Lu Xixi Yan Yang Li Xinmei Li Zhuohui Li Zhipei Wu Zhenyu Wei Wei Wang Huimei Fan Yu Jiang Yan Xiong Yu Wang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第3期1041-1055,共15页
Background Thermogenic adipose tissue,both beige and brown,experiences whitening as animals are exposed to warmth and age,but the potential mechanisms are not fully understood.In this study,we employed singlenucleus R... Background Thermogenic adipose tissue,both beige and brown,experiences whitening as animals are exposed to warmth and age,but the potential mechanisms are not fully understood.In this study,we employed singlenucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes.Results Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues(pAT and oAT)exhibited progressive whitening in goats.Compared to the classic brown adipocytes in mice,goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes,which was also confirmed by adipocyte type-and lineage-specific marker expression analysis.Furthermore,trajectory analysis revealed beige-and white-like adipocytes deriving from a common origin,coexisting and undergoing the transdifferentiation.In addition,differences in gene expression profiles and cell communication patterns(e.g.,FGF and CALCR signaling)between oAT and pAT suggested a lower thermogenic capacity of oAT than that of pAT.Conclusions We constructed a cell atlas of goat pAT and oAT and descripted the characteristics of thermogenic adipocytes during whitening progression.Altogether,our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes,and providing new insights into obesity prevention in humans and cold adaptation in animals. 展开更多
关键词 Beige adipocytes snRNA-seq Thermogenic adipose tissue Whitening
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Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion 认领 引用 被引量：1
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作者 Yun Liu Zhi Yu +9 位作者 Xuan Wang Ming-Qian Yuan Meng-Jiang Lu Mei-Rong Gong Qian Li You-Bing Xia Guan-Hu Yang Bin Xu Gerhard Litscher Tian-Cheng Xu 《World Journal of Diabetes》 SCIE 2025年第5期254-270,共17页
BACKGROUND Electroacupuncture(EA)has been recognized for its beneficial effects on glucolipid metabolism,potentially through the regulation of sensory nerve coordination.The expandability of peripancreatic adipose tis... BACKGROUND Electroacupuncture(EA)has been recognized for its beneficial effects on glucolipid metabolism,potentially through the regulation of sensory nerve coordination.The expandability of peripancreatic adipose tissue(PAT)is implicated in the transition from obesity to type 2 diabetes mellitus(T2DM).However,the specific pancreatic responses to EA require further elucidation.AIM To investigate the influence of EA on pancreatic glucolipid reduction level in a high-fat diet(HFD)rat model.METHODS To delineate the precise pathway through which EA mediates interactions bet ween PAT and islets,we assessed the expression levels of NGF,TRPV1,insulin,as well as other proteins in the pancreas and PAT.This approach enabled us to identify the acupoints that are most conducive to optimizing glycolipid metabolism.RESULTS The ST25,LI11 and ST37 groups attenuated HFD-induced obesity and insulin resistance(IR)to distinct degrees,with ST25 group having the greatest effect.EA at ST25 was found to modify the local regulatory influence of PAT on the pancreatic intrinsic nervous system.Specifically,EA at ST25 obviously activated the TRPV1-CGRP-islet beta cell pathway,contributing to the relief of glucolipid metabolic stress.The beneficial effects were abrogated following the chemical silencing of TRPV1 sensory afferents,confirming their indispensable role in EA-mediated regulation of islet and PAT function.Furthermore,in TRPV1 knockout mice,a reduction in PAT inflammation was observed,along with the recovery of islet beta cell function.EA at LI11 and ST37 demonstrated anti-inflammatory properties and helped ameliorate IR.CONCLUSION The PAT ecological niche influenced the progression from obesity to T2DM through various immunometabolic pathways.EA at ST25 could regulate glucolipid metabolism via the TRPV1-CGRP-islet beta cell pathway. 展开更多
关键词 Insulin resistance Electroacupuncture Sensory nerve Transient receptor potential vanilloid 1 receptor Pancreatic beta cell Peripancreatic adipose tissue
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