期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到14篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Preparation and characterization of microalgae-derived extracellular vesicles and their protective effect on acute alcohol-induced liver injury 认领 引用
1
作者 Jiawen Song Lei Zhou +2 位作者 Shengfeng Peng David Julian McClements Wei Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2310-2322,共13页
Increased levels of alcohol consumption are linked to an increased risk of alcoholic liver disease.As a novel source of national food,microalgae are rich in bioactives and have been demonstrated to confer benefits to ... Increased levels of alcohol consumption are linked to an increased risk of alcoholic liver disease.As a novel source of national food,microalgae are rich in bioactives and have been demonstrated to confer benefits to human health.The effects of microalgae extracellular vesicles(M-EVs)on alcohol-induced liver injury have not been studied previously.In this study,3 types of M-EVs were isolated using a combination of tangential flow filtration(TFF)and size exclusion chromatography(SEC).The structure and composition of M-EVs were characterized and the safety and liver-accumulation of M-EVs were also confirmed.Results shown that 3 types M-EVs were shown to be colloidal particles((198.9±7.2),(191.7±5.1),and(259.5±8.1)nm)with negative charge((-25.0±1.6),(-21.4±0.6),and(-22.4±1.6)mV).M-EVs were able to reduce the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and triglycerides(TGs)in the mice and regulated the levels of malondialdehyde(MDA),glutathione(GSH),and superoxide dismutase(SOD),which protected the mice against oxidative damage and inflammation caused by alcohol-induced liver injury.In addition,the M-EVs may also have alleviated alcohol-induced liver injury through activation of the Nrf2/HO-1 signaling pathway and regulation of CYP2E1 expression,as well as by modulating the diversity and composition of the gut microbiota.The potentially beneficial effects of M-EVs on alcoholic liver disease may provide a theoretical basis for further exploration of the health function of M-EVs in the food industry. 展开更多
关键词 Alcohol-induced liver injury Microalgae Extracellular vesicles Nrf2/HO-1 signaling pathway Gut microbiota
暂未订购 下载PDF
The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice 认领 引用 被引量：5
2
作者 Yange Liu Ronglong Chen +7 位作者 Lanzhou Li Ruitao Dong Hui Yin Yawen Wang Anhui Yang Jianbin Wang Changtian Li Di Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2021年第4期497-507,共11页
The major pathologic hallmark of the alcoholic liver disease(ALD)is the representation of chronic alcohol-induced hepatocyte lipid accumulation.This study aims to investigate the hepatoprotective role of triterpenoids... The major pathologic hallmark of the alcoholic liver disease(ALD)is the representation of chronic alcohol-induced hepatocyte lipid accumulation.This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia(ACT)in chronic alcohol-induced liver injury mice,establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks.In longterm alcohol consumption mice,the significantly lost body weight,increased organ indexes,hepatic alanine aminotransferase and aspartate aminotransferase levels were all remissed after 6-week ACT orally administration,showing its hepatoprotective property.ACT suppressed the triglyceride,total cholesterol and low-density lipoprotein levels,and enhanced high-density lipoprotein levels in serum or/and liver of chronic alcohol damaged mice.Combining with the pathological observations,ACT displayed an anti-steatosis effects to restrain the progress of ALD.Based on proteomic analysis and enzyme-linked immunosorbent assay,ACT had been confi rmed to regulate the levels of lipid biogeneration-related factors and depressed the over-accumulation of hepatic reactive oxygen species.According to further data,ACT prevented alcoholic liver injury may be associated with mediating lipid metabolism-related to PGC-1αand NF-κB signaling.In summary,ACT protected the body against chronic alcohol ingest induced liver injury through its regulation lipid on metabolism. 展开更多
关键词 An trodia cinnamomea mycelia Triterpenoids Chronic alcohol-induced liver injury Lipid accumulation
暂未订购 下载PDF
Effects of a combination of Japanese Raisin Tree Seed and Flower of Lobed Kudzuvine against acute alcohol-induced liver injury in mice 认领 引用 被引量：5
3
作者 Wan Xu Shaohong Chen +6 位作者 Gansheng Zhong Haiyan Liu Linlin Xiu Xue Yu Feng Chen Na Li Yanmin Lv 《Journal of Traditional Chinese Medical Sciences》 CAS 2020年第1期59-67,共9页
Objective:The Flower of Lobed Kudzuvine[Pueraria lobata(Willd.)Ohwi;Gehua in Chinese;GH]and Japanese Raisin Tree Seed(Hovenia dulcis Thunnb.;Zhijuzi in Chinese;ZJZ)are herbs that have been used in China for the treatm... Objective:The Flower of Lobed Kudzuvine[Pueraria lobata(Willd.)Ohwi;Gehua in Chinese;GH]and Japanese Raisin Tree Seed(Hovenia dulcis Thunnb.;Zhijuzi in Chinese;ZJZ)are herbs that have been used in China for the treatment of alcohol intoxication and liver diseases.We aimed to evaluate the hepatoprotective potential of a combination of these in mice with acute alcohol-induced liver injury,and to elucidate the mechanisms involved.Methods:Male ICR mice were randomly allocated to six groups:a control group,an alcohol-administered group,and groups that were administered alcohol and one of silibinin,the GH,the ZJZ or a GH-ZJZ combination(at a ratio of 2:1).Animals were orally administered 56%alcohol(Er Guo-tou white spirit,0.12 mL/10 g/d)for 10 days and at the end of this period,hepatic biochemical indicators,antioxidant parameters,alcohol metabolic enzymes,and histopathologic changes were evaluated.Moreover,the expression of the signaling molecules KEAP1,NRF2,and AQP9 were measured by qRT-PCR and western blotting.Results:Compared with the model group,GH-ZJZ(2:1)had lower serum ALT(12.15±0.39,P紏.003),AST(104.07±1.03,P紏.001),and ALP(148.09±2.55,P紏.010)activities,and lower TC(1.97±0.05,P紏.001)and TG(1.54±0.07,P?.002)concentrations.GH-ZJZ(2:1)also significantly increased the hepatic activities of SOD and GSH(4.24±0.25 and 1.57±0.06,respectively;both P<.01),reduced the ROS and MDA concentrations(97.50±3.00 and 2.39±0.19,respectively;both P<.01),and upregulated Nrf2 expression(P<.01).GH-ZJZ(2:1)significantly reduced the expression of KEAP1 and AQP9 in the liver,compared with alcohol-administered mice(P<.01).Importantly,the GH-ZJZ combination caused a more marked improvement in acute liver injury than GH or ZJZ alone.Conclusion:We have demonstrated protective effects of GH-ZJZ(2:1)against acute alcohol-induced hepatic injury,and shown that these effects may be associated with improvements in lipid and alcohol metabolism,antioxidant capacity,and lipid peroxidation. 展开更多
关键词 GH-ZJZ combination Acute alcohol-induced liver injury Oxidative stress AQP9 KEAP1-NRF2-ARE
暂未订购 下载PDF
Alcohol-Induced Cardiomyopathy Presenting with Left Ventricular Apical Thrombus 认领 引用
4
作者 Farid Khan Casey Manzanero +1 位作者 Amit Bansal Sreekanth Kondareddy 《World Journal of Cardiovascular Diseases》 CAS 2022年第7期353-359,共7页
Background: Chronic excessive alcohol consumption has been strongly associated with alcohol-induced cardiomyopathy (AC) in patients with no evidence of coronary artery disease (CAD). AC may cause cardiovascular c... Background: Chronic excessive alcohol consumption has been strongly associated with alcohol-induced cardiomyopathy (AC) in patients with no evidence of coronary artery disease (CAD). AC may cause cardiovascular complications and significant impact on the quality of life. We discuss an interesting case of dilated cardiomyopathy, associated complication, diagnostic work-up and management. Case Report: A young male presented to our service with worsening dyspnea, orthopnea, and scrotal and lower extremity edema. On average, he consumed a pack of 12 beers every day and had a 30-pack-years smoking history. He was found to be in acute heart failure with evidence of pulmonary edema and cardiomegaly on chest imaging. He had biventricular dilatation and severely reduced left ventricular ejection fraction (LVEF) 15% in addition to a thrombus in the LV apex. The cardiac catheterization was unremarkable for CAD. He was diuresed appropriately resulting in significant weight loss and resolution of symptoms. LV thrombus was treated with unfractionated heparin infusion that was transitioned to warfarin. He was maintained on guidelines-directed medical therapy for heart failure. Extensive counseling was provided regarding alcohol and tobacco cessation. On follow-up echocardiogram, his LVEF improved and there was no evidence of LV thrombus. We think, the readership will benefit from our experience of treating a case of AC, and the importance of clinical history. Conclusion: Chronic excessive alcohol use is detrimental to cardiac function leading to alcohol-induced cardiomyopathy. A careful approach to clinical history of alcohol consumption and prompt diagnostic workup negative for ischemic causes may confirm the diagnosis. Cardiac function improves with guidelines-directed medical therapy for heart failure and abstinence from alcohol. 展开更多
关键词 Alcohol-Induced Cardiomyopathy Heart Failure Echocardiography Thrombus Diuresis
暂未订购 下载PDF
Improving hepatoprotective effect of naringin against alcohol-induced liver injury by encapsulation in microalgae-derived extracellular vesicles 认领 引用 被引量：1
5
作者 Jiawen Song Qianqian Jiao +4 位作者 Lei Zhou Shengfeng Peng Suyun Lin David Julian McClements Wei Liu 《Food Bioscience》 SCIE 2025年第2期1478-1492,共15页
Naringin is a dietary flavonoid that exhibits hepatoprotective effects against alcoholic liver disease(ALD).However,its hepatoprotective potential is limited by its low solubility,bioavailability,and bioactivity.In th... Naringin is a dietary flavonoid that exhibits hepatoprotective effects against alcoholic liver disease(ALD).However,its hepatoprotective potential is limited by its low solubility,bioavailability,and bioactivity.In this study,Scenedesmus-derived extracellular vesicles(SEVs)were successfully isolated,characterized,and utilized as delivery systems.Naringin was successfully loaded into the SEVs(Nar-SEVs)using a pH-driven method.The Nar-SEVs displayed high encapsulation efficiency,good storage stability,cytocompatibility,and liver-targeting.An in vivo mice study showed that Nar-SEVs reduced oxidative stress and inflammation in the liver,thereby protecting it from alcohol-induced injury.Moreover,Nar-SEVs alleviated alcohol-induced liver injury through activation of the Nrf2/HO-1 signaling pathway and regulation of CYP2E1 expression,as well as by modulating the diversity and composition of the gut microbiota.These results may facilitate the development of naringin-based functional foods,supplements and drugs designed to target ALD. 展开更多
关键词 Alcohol-induced liver injury Naringin Extracellular vesicles Nrf2/HO-1 signaling pathway Gut microbiota
Achyranthes bidentata polysaccharides alleviate alcohol-induced gut-liver injury via farnesoid X receptor pathway 认领 引用
6
作者 Tao Jiang Ruiling Fan +5 位作者 Bingqi Zhang Juan Xiong Ningjing Pu Mingcai Zhao Yuanbiao Guo Qianyuan Gong 《Food Bioscience》 SCIE 2025年第6期4786-4795,共10页
The farnesoid X receptor(FXR)plays a crucial role in alcohol-induced gut-liver axis injury.This study was designed to evaluate the therapeutic potential of Achyranthes bidentata polysaccharides(ABPs)in treating alcoho... The farnesoid X receptor(FXR)plays a crucial role in alcohol-induced gut-liver axis injury.This study was designed to evaluate the therapeutic potential of Achyranthes bidentata polysaccharides(ABPs)in treating alcohol-induced gut and liver injury in mice and to determine whether ABPs exert effects via FXR.Initially,the biological safety of ABPs in mice was confirmed by assessing serum levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),as well as through hematoxylin and eosin staining of organ tissues.Subsequently,alcohol-induced liver and gut injury was established in mice using a liquid alcohol diet,followed by treatment with ABPs.The results demonstrated that oral administration of ABPs significantly reduced serum levels of ALT,AST,and total bile acids.Furthermore,ABPs treatment attenuated inflammatory cell infiltration and lipid droplet deposition in liver tissues,thereby ameliorating alcohol-induced liver injury.Additionally,ABPs modulated the FXR-SHP-CYP7A1 signaling pathway in the liver.ABPs also significantly repaired ileum injury in alcohol-induced liver disease mice and regulated FXR-FGF15 transcript levels in the ileum.Further,we validated the ability of ABPs restore the damaged intestinal barrier using intestinal epithelial cells.Collectively,our research revealed that oral administration of with ABPs exert a protective effect against alcohol-induced liver and ileal injury,primarily through the modulation of the FXR and associated signaling pathways within the gutliver axis. 展开更多
关键词 Achyranthes bidentata Polysaccharides Gut-liver axis Alcohol-induced liver disease Farnesoid X receptor
L-theanine protects against acute alcohol-induced brain injury via cGMP/PKG signaling activation 认领 引用
7
作者 Jiahao Yang Xuhui Dang +4 位作者 Simin Tan Jiayou Gu Kehong Liu Zhihua Gong Wenjun Xiao 《Food Bioscience》 SCIE 2025年第12期1425-1438,共14页
Excessive alcohol consumption over a short period can result in acute alcohol-induced brain injury(AIBI),characterized by brain inflammation,oxidative stress imbalance,and cognitive impairment,such as a 20%increase in... Excessive alcohol consumption over a short period can result in acute alcohol-induced brain injury(AIBI),characterized by brain inflammation,oxidative stress imbalance,and cognitive impairment,such as a 20%increase in TNF-α.L-Theanine(LTA),a unique non-protein amino acid found in tea leaves,is known to mitigate alcohol-induced immune disorders and oxidative stress.However,its protective role against AIBI is poorly un-derstood.This study aimed to investigate the protective effects and underlying mechanisms of LTA in AIBI.We administered different doses of LTA(100,200,400 mg kg-1⋅d-1)to mice for 28 days and established an AIBI model by feeding them a 5%ethanol Lieber-DeCarli diet followed by an 8-day acute alcohol binge.LTA significantly reduced autonomic behavioral disorders,brain tissue damage,inflammatory factor release,oxidative stress imbalance,and neurotransmitter disorders caused by AIBI,with the 400 mg kg-1·d-1dose being the most effective.Tandem mass tag proteomic analysis revealed that LTA primarily involves the cyclic gua-nosine monophosphate(cGMP)/protein kinase G(PKG)pathway.Quantitative PCR and western blotting confirmed that key proteins in this pathway,such as PKG(↑1.5-fold,P<0.01),PI3K(↑1.2-fold,P<0.01),p-AKT(↑1.4-fold,P<0.01)and p-CREB(↑1.3-fold,P<0.01)were significantly upregulated,whereas IP3R(↓0.6-fold,P<0.01)and MCU(↓0.5-fold,P<0.01)were downregulated.These results suggest that LTA alleviates acute alcoholic brain injury by activating the cGMP-PKG signaling pathway,offering a potential nutritional intervention strategy for AIBI protection. 展开更多
关键词 L-theanine Alcohol-induced brain damage cGMP-PKG signaling pathway Inflammation of the brain Neuroprotection Mouse model
Protection role of resveratrol against alcohol-induced heart defect in zebrafish embryos 认领 引用 被引量：2
8
作者 Feng Wang Jia Lin +3 位作者 Jing Jian You-Hua Wang Ning Guo Qiang Li 《Chinese Medical Journal》 SCIE CAS CSCD 2019年第8期990-993,共4页
To the Editor:Alcohol-induced heart defect is one of the most important clinical manifestations of fetal alcohol spectrum disorder(FASD),characterized by atrioventricular septal defect and arterial conical deformity.[... To the Editor:Alcohol-induced heart defect is one of the most important clinical manifestations of fetal alcohol spectrum disorder(FASD),characterized by atrioventricular septal defect and arterial conical deformity.[1]Resveratrol,a polyphenol component of the traditional Chinese herb Polygonum cuspidatum,which is mainly extracted from its rhizome,is known to exhibit beneficial effects on the cardiovascular system.For example,resveratrol has beneficial effects on heart dysfunction,myocardial hypertrophy,and pressure overload.Moreover,resveratrol was found to inhibit platelet aggregation,prevent atherosclerosis,and scavenge free radicals.[2]However,the effect of resveratrol on alcohol-induced heart defect during heart formation is still unknown.The unique characteristics of zebrafish embryos,such as their transparent body,in vitro fertilization,and short reproductive cycle,make them an attractive tool for cardiovascular research.Moreover,the immersion-based alcohol delivery method used with zebrafish embryos is non-invasive unlike most of the alcohol administration protocols applied in rodent models. 展开更多
关键词 resveratrol against alcohol-induced heart defect zebrafish embryos fetal alcohol spectrum disorder(FASD)
Lysosome and proteasome dysfunction in alcohol-induced liver injury 认领 引用 被引量：2
9
作者 Terrence M.Donohue.Jr Natalia A.Osna +1 位作者 Kusum K.Kharbanda Paul G.Thomes 《Liver Research》 2019年第3期191-205,共15页
The review describes research findings on the influence of alcohol consumption on two crucial catabolic systems in hepatocytes:the lysosome and the ubiquitin-proteasome system(UPS).The lysosome is a membrane-bound org... The review describes research findings on the influence of alcohol consumption on two crucial catabolic systems in hepatocytes:the lysosome and the ubiquitin-proteasome system(UPS).The lysosome is a membrane-bound organelle that degrades all aging and/or damaged organelles and hydrolyzes all forms of macromolecules.The UPS is mostly proteolytic.It carries out the majority of its functions in the soluble portion of the cytoplasm(cytosol)and degrades nearly all intracellular proteins,particularly those with short half-lives,so that their levels are tightly controlled.Our review will briefly discuss the epidemiology of alcohol abuse and the spectrum of alcohol-induced liver disease(AILD).We will explain why ethanol(EtOH)metabolism,but not EtOH alone,is hepatotoxic.Then,we will summarize how heavy drinking alters hepatic catabolic systems,resulting in liver enlargement that develops from hepatocyte swelling due,in part,to aberrant accumulation of undegraded lipid droplets(steatosis)and undegraded proteins(proteopathy).Our detailed description of each catabolic system will highlight its discoverer(s)and emphasize each system’s characteristics.Most important,we will review the evidence that chronic EtOH consumption disrupts hepatic lysosome biogenesis and inhibits the UPS by impeding hepatic proteasome activity.It will become evident that each of these EtOH-induced defects has far-reaching functional consequences.Finally,we will describe current and potential therapeutic interventions for alleviating EtOH-induced liver injury.The most effective intervention is the cessation of EtOH consumption.However,there are other potential approaches using natural or synthetic compounds that activate autophagy or the proteasome to enhance the degradation of accumulated lipid droplets or proteins,respectively,which could alleviate AILD.These approaches,now in their early stages of investigation,will also be discussed in this review. 展开更多
关键词 Alcohol Lysosome Proteasome Ethanol Liver Proteostasis Lipostasis Alcohol-induced liver disease(AILD)
Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury 认领 引用
10
作者 Xiaoyi Tan Yumeng Wang +5 位作者 Mingyu Liu Jing Gan Jingwen Wu Yawen Liang Guanghua Zhao Chenyan Lv 《Food Bioscience》 SCIE 2022年第4期415-424,共10页
Alcohol abuse induced liver damage are closely related to oxidative stress,several efforts have been made to quench free radicals produced in the liver.Heteropolymeric soybean seed ferritin has been proved to protect ... Alcohol abuse induced liver damage are closely related to oxidative stress,several efforts have been made to quench free radicals produced in the liver.Heteropolymeric soybean seed ferritin has been proved to protect DNA from oxidative damage.However,the roles of homopolymeric apoferritin in quenching free radicals have been neglected so far.In order to improve the ferroxidase activity of ferritin,we have prepared apo ferritin by removing iron core from the cavity.In this study,the roles of apo shrimp ferritin(Marsupenaeus japonicus ferritin,MjFer)and human H chain ferritin(HuHF)in attenuating the hydroxyl radicals in vitro and in vivo has been investigated.Results showed that MjFer was able to quench the free radicals produced by iron oxidation more efficiently than HuHF in vitro.Animal studies using a mouse model of alcohol-induced acute liver injury revealed that MjFer is much more efficacious than HuHF in alleviating the liver injury,by attenuating oxidative stress and regulating Nrf2/HO1 expression.Accordingly,the higher activity of MjFer may be attributed to its faster iron oxidative rate than HuHF,which may help improve the intestinal integrity,and reduce abnormal iron absorption.As expected,iron contents in the liver of MjFer and HuHF group are much lower than that of model group,further alleviating the liver damage.These findings suggest that apoferritin may be a promising candidate for alcohol-induced liver injury. 展开更多
关键词 Apoferritin Alcohol-induced liver damage Oxidative stress Iron metabolism
中西医结合治疗酒精性骨质疏松的研究进展 认领 引用
11
作者 任思路 赵文韬 +7 位作者 郭志伟 孔俊博 陈均荣 李卓纹 余谨灵 段星辰 马怀桐 尹本敬 《云南中医中药杂志》 2026年第5期138-142,共5页
酒精性骨质疏松(alcohol-induced osteoporosis AOP)是一种因长期过量饮酒引起的骨密度下降及骨质脆弱的疾病,严重影响患者的生活质量,已成为全球范围内亟待解决的公共健康问题。近年来,随着对酒精性骨质疏松病理机制的深入研究,中西医... 酒精性骨质疏松(alcohol-induced osteoporosis AOP)是一种因长期过量饮酒引起的骨密度下降及骨质脆弱的疾病,严重影响患者的生活质量,已成为全球范围内亟待解决的公共健康问题。近年来,随着对酒精性骨质疏松病理机制的深入研究,中西医结合疗法逐渐受到关注并展现出良好的疗效。传统中医在理论指导和临床实践中,通过调和阴阳、活血化瘀等手段,在AOP的治疗中发挥着独特优势;现代西医则通过药物治疗(如双膦酸盐、选择性雌激素受体调节剂等)和营养补充(如钙剂、维生素D)来改善骨密度和骨骼强度。综述目前中西医结合疗法在酒精性骨质疏松治疗中的研究进展,旨在为未来的研究和临床实践提供参考,以期进一步改善患者的骨骼健康和生活质量。 展开更多
关键词 酒精性骨质疏松(Alcohol-induced osteoporosis AOP) 中西医结合疗法 治疗进展 综述
暂未订购 下载PDF
Ohio solid organ transplantation consortium criteria for liver transplantation in patients with alcoholic liver disease 认领 引用 被引量：2
12
作者 Kaveh Hajifathalian Annette Humberson +6 位作者 Mohamad A Hanouneh David S Barnes Zubin Arora Nizar N Zein Bijan Eghtesad Dympna Kelly Ibrahim A Hanouneh 《World Journal of Hepatology》 2016年第27期1149-1154,共6页
AIM To evaluate risk of recidivism on a case-by-case basis.METHODS From our center's liver transplant program,we selected patients with alcoholic liver disease who were listed for transplant based on Ohio Solid Or... AIM To evaluate risk of recidivism on a case-by-case basis.METHODS From our center's liver transplant program,we selected patients with alcoholic liver disease who were listed for transplant based on Ohio Solid Organ Transplantation Consortium(OSOTC) exception criteria.They were considered to have either a low or medium risk of recidivism,and had at least one or three or more months of abstinence,respectively.They were matched based on gender,age,and Model for End-Stage Liver Disease(MELD) score to controls with alcohol-induced cirrhosis from Organ Procurement and Transplant Network data.RESULTS Thirty six patients with alcoholic liver disease were approved for listing based on OSOTC exception criteria and were matched to 72 controls.Nineteen patients(53%) with a median [Inter-quartile range(IQR)] MELD score of 24(13) received transplant and were followed for a median of 3.4 years.They were matched to 38 controls with a median(IQR) MELD score of 25(9).At one and five years,cumulative survival rates(± standard error) were 90% ± 7% and 92% ± 5% and 73% ± 12% and 77% ± 8% in patients and controls,respectively(Log-rank test,P = 0.837).Four(21%) patients resumed drinking by last follow-up visit.CONCLUSION Compared to traditional criteria for assessment of risk of recidivism,a careful selection process with more flexibility to evaluate eligibility on a case-by-case basis can lead to similar survival rates after transplantation. 展开更多
关键词 Alcohol-induced disorders Alcoholic liver cirrhosis Mortality Survival Liver transplantation
暂未订购 下载PDF
Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats 认领 引用 被引量：10
13
作者 Carlett Ramírez-Farías Eduardo Madrigal-Santillán +6 位作者 José Gutiérrez-Salinas Nidia Rodríguez-Sánchez Maricela Martínez-Cruz Ilse Valle-Jones Ingrid Gramlich-Martínez Alejandra Hernández-Ceruelos José A Morales-González 《World Journal of Gastroenterology》 SCIE CAS 2008年第6期899-907,共9页
AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided... AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided into five groups (groups 1-5). During the experiment, animals of Group 1 drank only water. The other four groups (2-5) drank 30 mL of ethanol/L of water. Group 3 additionally received vitamin A, those of group 4 vitamin C and those of group 5 received vitamin E. Subsequently serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin and bilirubin were measured colorimetrically. Lipid peroxidation (thiobarbituric-acid reactive substances, TBARS) both in plasma and liver was measured, as well as liver mass gain assessment and total DNA. RESULTS: Compared with sham group, serum AST and ALT increased significantly under ethanol treatment (43% and 93%, respectively, with P < 0.05). Vitamin C and vitamin E treatment attenuated the ethanol-induced increases in ALT and AST activity. Ethanol treatment also decreased serum albumin concentration compared to sham group (3.1 ± 0.4 g/dL vs 4.5 ± 0.2 g/dL; P < 0.05). During liver regeneration vitamins C and E significantly ameliorated liver injury for ethanol administration in hepatic lipid peroxidation (4.92 nmol/mg and 4.25 nmol/mg vs 14.78 nmol/mg, respectively, with P < 0.05). In association with hepatic injury, ethanol administration caused a significant increase in both hepatic and plasma lipid peroxidation. Vitamins (C and E) treatment attenuated hepatic and plasma lipid peroxidation. CONCLUSION: Vitamins C and E protect against liver injury and dysfunction, attenuate lipid peroxidation, and thus appear to be significantly more effective than vitamin A against ethanol-mediated toxic effects during liver regeneration. 展开更多
关键词 Lipid peroxidation Antioxidant vitamins Alcohol-induced liver injury Liver regeneration
暂未订购 下载PDF
The Impact of SARS-CoV-2 on Liver Diseases and Potential Phytochemical Treatments 认领 引用 被引量：1
14
作者 Dhanvee Balaji Ranjith Balakrishnan +4 位作者 Dhasarathdev Srinivasan Rajasekaran Subbarayan Rupendra Shrestha Nityanand Srivastava Ankush Chauhan 《Infectious Microbes & Diseases》 CSCD 2024年第4期177-188,共12页
The COVID-19 pandemic,caused by the SARS-CoV-2 virus,has brought about numerous challenges.One of these challenges is the impact of SARS-CoV-2 on the liver.Although this virus primarily affects the lungs,it can induce... The COVID-19 pandemic,caused by the SARS-CoV-2 virus,has brought about numerous challenges.One of these challenges is the impact of SARS-CoV-2 on the liver.Although this virus primarily affects the lungs,it can induce elevated transaminase levels and the development of scar tissue in the liver,exacerbating preexisting liver conditions.Individuals with preexisting conditions,such as nonalcoholic fatty liver disease,alcohol-induced liver disease and hepatocellular carcinoma,face an increased risk of mortality from COVID19.However,drugs currently used to treat COVID-19 have undesirable side effects,which make them unsuitable for patients with preexisting liver conditions.In this review,we explore the potential of phytochemicals,such as apigenin,berberine,curcumin,epigallocatechin-3-gallate,quercetin,resveratrol and silymarin,for treatment of the liver conditions,including nonalcoholic fatty liver disease,alcohol-induced liver disease and hepatocellular carcinoma.We also discuss significant associations between phytochemicals and COVID-19 by depicting their molecular interactions.Based on the discussed overlapping functions,it is important to assess the therapeutic efficacy of phytochemicals that possess hepatoprotective properties as potential alternative treatments for COVID-19. 展开更多
关键词 COVID-19 nonalcoholic fatty liver disease alcohol-induced liver injury hepatocellular carcinoma phytochemicals hepatoprotective
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈