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Benzyl sulfide, sulfoxide and sulfinate metabolites from Gastrodia elata and their synthesis, derivatization and anti-inflammatory activity 认领 引用
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作者 Chengbo Xu Lei Wang +7 位作者 Xue Zhou Shuai Shao Chengjuan Chen Xiaoqiang Lei Tiantai Zhang Jiachen Zi Jiangong Shi Qinglan Guo 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期365-372,共8页
Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were ... Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were isolated from the aqueous extracts of Gastrodia elata.Compounds 1 and 4 are 4-hydroxy-3-(4′-hydroxybenzyl)benzyl-substituted sulfoxide and sulfide, respectively, which are unprecedented in natural products. Compound 3 represents a rare sulfinate. Several isolates and their sulfone and disulfide analogs(10-13) were synthesized to evaluate their anti-inflammatory activity. Notably, the synthesized sulfone 10 demonstrated significant alleviation of symptoms in multiple in vivo inflammatory models. 展开更多
关键词 Gastrodia elata Sulfur-bearing benzyl metabolites Synthesis Anti-inflammatory activity
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Mitochondria as the Bridge between Injury and Protection:The Role of Melatonin in Non-Steroidal Anti-Inflammatory Drug-Induced Gastric Ulcers 认领 引用
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作者 Debasish Bandyopadhyay Romit Majumder +2 位作者 Madhuri Datta Adrita Banerjee Aindrila Chattopadhyay 《BIOCELL》 SCIE 2026年第6期71-90,共20页
Non-steroidal anti-inflammatory drugs(NSAIDs)are widely prescribed,but their long-term use frequently results in gastric mucosal injury.Emerging evidence indicates that,beyond cyclooxygenase inhibition,mitochondrial d... Non-steroidal anti-inflammatory drugs(NSAIDs)are widely prescribed,but their long-term use frequently results in gastric mucosal injury.Emerging evidence indicates that,beyond cyclooxygenase inhibition,mitochondrial dysfunction represents a central mechanism driving NSAID-induced gastric epithelial damage.This review aims to critically synthesize current evidence on mitochondria-centered pathways involved in NSAID-induced gastric ulceration and to evaluate the therapeutic relevance of melatonin in this context.We highlight how NSAIDs impair mitochondrial bioenergetics,promote excessive reactive oxygen species generation,disrupt membrane potential,and activate apoptotic signaling,thereby compromising mucosal integrity.Importantly,melatonin exerts multifaceted gastroprotective actions by preserving mitochondrial function,restoring redox homeostasis,modulating apoptosis,and facilitating mucosal repair.Collectively,the available data identify mitochondria as both the primary site of injury and a viable therapeutic target in NSAID-induced gastric ulcers.This mechanistic framework positions melatonin as a promising adjunct strategy for mitigating NSAID-associated gastric damage and improving mucosal defense. 展开更多
关键词 Mitochondrial dysfunction melatonin non-steroidal anti-inflammatory drug gastric ulcers oxidative stress gastroprotection
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Penicipenoids A−G,antioxidant and anti-inflammatory cadinane sesquiterpenoids with rearranged carbon skeletons from the marine sponge symbiotic Penicillium sp.5975 认领 引用
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作者 Dongdong Xie Peihai Li +6 位作者 Lu Zhang Ruyi Shang Jiaxin Li Kechun Liu Houwen Lin Shuping Wang Weihua Jiao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第5期632-640,共9页
Seven new sesquiterpenes,named penicipenoids A−G(1−7),were isolated from rice-based fermentation cultures of the marine sponge-derived fungus Penicillium sp.5975,together with ten known analogues(8−17).Their structure... Seven new sesquiterpenes,named penicipenoids A−G(1−7),were isolated from rice-based fermentation cultures of the marine sponge-derived fungus Penicillium sp.5975,together with ten known analogues(8−17).Their structures were elucidated using high-resolution mass spectrometry(HR-MS)and nuclear magnetic resonance(NMR)spectroscopy,supported by single-crystal X-ray diffraction analysis and electronic circular dichroism(ECD)calculations.Penicipenoid A(1)features an unprecedented sesquiterpene scaffold characterized by a tricyclo[4.4.11,602,7]hendecane core.Penicipenoid D(4)contains an unusual furan substructure within the cadinane-type sesquiterpenoid class,while penicipenoid F(6)represents a rare norsesquiterpene derivative lacking the carbon atom at the C-7 position.The in vivo antioxidant and anti-inflammatory effects of these compounds were evaluated using transgenic fluorescent zebrafish models.Penicipenoids A−C(1−3)exhibited anti-oxidant activity in metronidazole(MTZ)-treated transgenic zebrafish embryos,whereas penicipenoid E(5)demonstrated potent anti-inflammatory activity in CuSO4-induced transgenic fluorescent zebrafish embryos. 展开更多
关键词 Penicillium sp. Cadinane ses-quiterpenoids Antioxidant activity Anti-inflammatory Rearranged carbon skeleton
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First discovery of triterpenoids and sterols from Cotinus coggygria var.cinereus Engl.with anti-inflammatory and antibacterial activities 认领 引用
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作者 Yue-Tong Zhu Ze-Rui Li +5 位作者 Ren-Hao Chen Jin-Hao Li Wei Wang Yu-Qi Gao Chun-Huan Li Jin-Ming Gao 《Natural Products and Bioprospecting》 CSCD 2026年第1期1-18,共18页
This study led to the isolation of 17 triterpenoids,including two lanostane-type(1 and 2),two dammarane-type(3 and 7),ten tirucallane-type(4 and 8-16),and three oleanane-type(17-19)triterpenoids,as well as nine sterol... This study led to the isolation of 17 triterpenoids,including two lanostane-type(1 and 2),two dammarane-type(3 and 7),ten tirucallane-type(4 and 8-16),and three oleanane-type(17-19)triterpenoids,as well as nine sterols(5,6,and 20-26)from Cotinus coggygria var.cinereus Engl,which were first discovered from the genus Cotinus.Among them,coggygrenoids A-D(1-4),coggygrerol A(5),and coggygrerol B(6)are undescribed compounds.Addition-ally,seven flavonoids(27-33)were also isolated from this plant.Compound 15 displayed inhibitory activities in LPS-induced RAW 264.7 cells with an IC50 value 6.81±0.15 μM.Molecular docking demonstrated that 15 exhibited favorable affinity for NLRP3 and iNOS.In vitro and in vivo antibacterial evaluations indicated that coggygrnoid C(3)exhibited significant inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC BAA-1717(USA300),with An MIC of 8 μg/mL.Further mechanistic investigations demonstrated that 3 exerted antibacterial activity by compromising the integrity of the cell wall and membrane.Notably,the combination of 3 with ampicillin exhibited an additive antibacterial effect.In the Galleria mellonella infection model,compound 3 exhibited comparable activ-ity to that of the positive control at 20 mg/kg.These findings suggest that triterpenoids of C.coggygria are potential antibacterial lead agents. 展开更多
关键词 Cotinus coggygria var.cinereus Engl. Triterpenoids Sterols Anti-inflammatory activity Antibacterial activity
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Two New Linear Furocoumarins from Notopterygium incisum and Their Anti-inflammatory Activity 认领 引用
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作者 Hu Su Zhao Lilian +4 位作者 Li Xinyu Ye Yubei Deng Yun Huang Lijun Guo Dale 《有机化学》 SCIE CAS CSCD 北大核心 2026年第1期300-303,共4页
Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compound... Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compounds were elucidated through analysis of spectroscopic evidence,including data obtained from high-resolution electrospray ionization mass spectrometry(HRESIMS)and nuclear magnetic resonance(NMR).The absolute configurations of Notoprenylate L(1)and Nototerprinol K(2)were further confirmed using electronic circular dichroism(ECD)calculations.Compound 1 demonstrated the ability to inhibit the expression of nitric oxide(NO),a pro-inflammatory factor,in lipopolysaccharide-induced RAW264.7 macrophages at a concentration of 7.5μmol/L,indicating its potential for anti-inflammatory activity. 展开更多
关键词 Notopterygium incisum linear furocoumarin anti-inflammatory activity
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Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis:Insights into its anti-inflammatory and antinociceptive activities 认领 引用
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作者 Paola B Da Silva Laís Lopes-Bute +8 位作者 Janaína Fischer Ana P Parcianello Cinthia F Wendel Renata Pires-Duarte Rafael M Luiz Ana P C Brandalize Ana C Zarpelon-Schutz Fabrício F Melo Kádima N Teixeira 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第5期248-264,共17页
BACKGROUND Colorectal cancer(CRC)remains among the most common causes of cancerrelated deaths worldwide.Ulcerative colitis and Crohn’s disease are inflammatory bowel diseases characterized by recurrent episodes of in... BACKGROUND Colorectal cancer(CRC)remains among the most common causes of cancerrelated deaths worldwide.Ulcerative colitis and Crohn’s disease are inflammatory bowel diseases characterized by recurrent episodes of inflammation in the gastrointestinal tract,which increase the risk of developing CRC.One of the main pathways activated during the inflammatory process is sphingosine-1-phosphate(S1P).S1P activates the signal transducer and activator of transcription 3(STAT3).Phosphorylated STAT3 inhibits apoptotic pathways,promoting tumorigenesis and,consequently,the development of CRC.Compounds with antioxidant potential,such as the hydroalcoholic extract of Butia capitata fruit pulp(HAEBC),may act to reduce oxidative stress,thereby decreasing inflammatory events.AIM To evaluate the anti-inflammatory and antinociceptive effects of HAEBC in an experimental colitis model and to investigate,in silico,the interaction of its phenolic compounds with molecular targets.METHODS HAEBC was prepared using a modified protocol and administered in 10%dimethyl sulfoxide in saline.Male and female Swiss mice were used for pain tests induced by acetic acid,formalin,and carrageenan.Acute colitis was induced by intracolonic administration of acetic acid after pretreatment with HAEBC,mesalazine,or saline.Macroscopic lesions,histological changes,and visceral hyperalgesia(von Frey test)were evaluated.Statistical analysis was performed using one-way analysis of variance followed by Tukey’s test.In silico analyses explored potential anti-inflammatory targets of HAEBC compounds,including sphingosine kinase 1(SPHK1),indoleamine 2,3-dioxygenase 1(IDO1),and cyclooxygenase-2(COX-2).RESULTS Pre-treatment with HAEBC at doses of 30 and 100 mg/kg significantly reduced contortions in mice(58%and 49%,respectively),with time-dependent effects.The extract inhibited both the neurogenic and inflammatory phases of the formalin test,decreasing paw flinching and licking time,indicating action on nociceptors and inflammatory mediators such as prostaglandins and cytokines.HAEBC at 100 mg/kg also reduced carrageenan-induced paw edema by 63%.In acute colitis,treated mice showed more than 75%inhibition of macroscopic lesions and preserved colon architecture,unlike mesalazine-treated animals.In the von Frey test,HAEBC at 300 mg/kg outperformed both the 10 mg/kg dose and mesalazine.Docking analyses indicated that gallic acid,p-hydroxybenzoic acid,and chlorogenic acid interact with SPHK1,IDO1,COX-2,and sphingosine 1-phosphate receptor 1,with chlorogenic acid forming the most stable complexes.CONCLUSION HAEBC exhibited anti-inflammatory and antinociceptive effects,preserving tissue integrity and reducing hyperalgesia.The proposed molecular interactions remain hypothetical.Implications for tumorigenesis are indirect and require validation using chronic models and molecular analyses. 展开更多
关键词 Antinociceptive activity Anti-inflammatory activity Butia capitata Colorectal cancer Cyclooxygenase-2 Phenolic compounds Ulcerative colitis
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Investigation on Chemical Constituents from Prunus cerasifera Ehrh.Fruits and Evaluation of Their Anti-Inflammatory Activity 认领 引用
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作者 Haofan Lv Qihang Zhang +3 位作者 Yufan He Wuwei Xin Wei Liu Chunpeng Wan 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第4期203-213,共11页
The fruits of Prunus cerasifera Ehrh.have been traditionally utilized as both medicinal and edible resource,however,their specific phytochemical profile and anti-inflammatory mechanisms remain to be fully elucidated.T... The fruits of Prunus cerasifera Ehrh.have been traditionally utilized as both medicinal and edible resource,however,their specific phytochemical profile and anti-inflammatory mechanisms remain to be fully elucidated.This study aimed to isolate and identify the chemical constituents from the fruits and evaluate their anti-inflammatory activities.The separation was performed using a combination of chromatographic techniques.The structures of the obtained compounds were elucidated using a combination of 1H and 13C nuclear magnetic resonance(NMR)and electrospray ionization mass spectrometry(ESI-MS).The anti-inflammatory activity of the compounds was initially investigated based on their capacity to inhibit nitric oxide(NO)release from lipopolysaccharide(LPS)-stimulated RAW264.7 macrophages and further validated in a zebrafish inflammatory model.The results indicated that eight compounds were successfully isolated from Prunus cerasifera Ehrh.fruits for the first time,including ursolic acid(1),corosolic acid(2),oleanolic acid(3),maslinic acid(4),2-O-(3′,4′-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid(5),neochlorogenic acid(6),chlorogenic acid(7),3-O-p-coumaroylquinic acid(8).In the LPS-induced RAW264.7 cell model,compounds 6 and 7 exhibited stronger activity than the positive control dexamethasone(Dex,IC50=11.13μM±0.43μM),with IC50 values of 6.33μM±0.18μM and 8.06μM±0.35μM,respectively.In the LPS-induced zebrafish inflammation model,compounds 6 and 7 again demonstrated significant efficacy,exerting their anti-inflammatory effect primarily through the modulation of pro-inflammatory factors Interleukin-6(IL-6)and Interleukin-1β(IL-1β). 展开更多
关键词 Prunus cerasifera Ehrh. triterpenoids phenolic acids anti-inflammatory
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Pharmacological Effects of Piceatannol on Anti-tumor,Anti-inflammatory,Antiviral,and Liver Protection 认领 引用
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作者 Junhao LI Quan QUAN +4 位作者 Xichun HUANG Zhao NING Hongye LI Wenhui ZHAO Chenghao JIN 《Asian Agricultural Research》 2026年第6期26-29,32,共4页
Piceatannol(PIC)is a natural stilbene polyphenol found in various plants,which has pharmacological effects such as anti-tumor,anti-inflammatory,antiviral,liver protection,myocardial protection,and eye tissue protectio... Piceatannol(PIC)is a natural stilbene polyphenol found in various plants,which has pharmacological effects such as anti-tumor,anti-inflammatory,antiviral,liver protection,myocardial protection,and eye tissue protection.PIC can inhibit the proliferation of liver cancer cells and induce apoptosis and autophagy by activating the ULK1/Atg13 signaling pathway.PIC can reduce HBV inflammation by downregulating the Notch pathway.Through antioxidant,anti-inflammatory,and anti abnormal autophagy,PIC can relieve vomiting toxin induced liver injury.By inhibiting the HMGB1/TLR4/NF-κB pathway,PIC can protect myocardium.By activating the SIRT1/FOXO3a/BNIP3 pathway,PIC can protect corneal epithelial cells from oxidative damage.PIC can directly inhibit rotavirus and conduct antiviral biosynthesis.PIC has high safety,multi-target regulation,and good development prospects,but its molecular mechanism and clinical efficacy still need to be further studied. 展开更多
关键词 Piceatannol Anti-tumor Anti-inflammatory Liver protection Antiviral Myocardial protection
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Pharmacological Effects of Combretastatin on Anti-tumor,Anti-inflammatory,Antifungal,and Immunomodulation 认领 引用
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作者 Wenhui ZHAO Quan QUAN +4 位作者 Xichun HUANG Junhao LI Zhao NING Hongye LI Chenghao JIN 《Medicinal Plant》 2026年第4期19-22,共4页
Combretastatin is a natural active substance isolated from the bark of South Africa Combretum alfredii,which has pharmacological activities such as anti-tumor,anti-inflammatory,antifungal,and immunomodulation.In terms... Combretastatin is a natural active substance isolated from the bark of South Africa Combretum alfredii,which has pharmacological activities such as anti-tumor,anti-inflammatory,antifungal,and immunomodulation.In terms of anti-tumor effects,it exerts the effects by inhibiting tumor cell proliferation,inducing apoptosis,and suppressing angiogenesis.The mechanism involves activation of the caspase family and regulation of the VEGF/VEGFR-2 and Notch signaling pathways.In terms of anti-inflammatory effects,it inhibits the release of pro-inflammatory factors such as TNF-α and IL-6 by blocking the NF-κB pathway.In terms of antifungal effects,it targets fungal microtubule proteins and induces microtubule depolymerization.In terms of immunomodulation,it promotes the proliferation of immune cells and regulates M1 polarization of macrophages.In this paper,the core pharmacological effects and molecular mechanisms of combretastatin are reviewed,providing theoretical references for its new drug development. 展开更多
关键词 Combretastatin Anti-tumor Anti-inflammatory Antifungal Immunomodulation
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Pharmacological Effects of Lupeol:Antitumor,Anti-inflammatory,Antioxidant,and Antidiabetic Activities 认领 引用
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作者 Jiaru YE Huizhen PEI +3 位作者 Shuang REN Linbo JIA Junhao LI Chenghao JIN 《Asian Agricultural Research》 2026年第8期29-32,42,共4页
Lupeol(LUP)is a natural triterpenoid compound derived from various plants,exhibiting pharmacological effects including tumor inhibition,inflammation suppression,antioxidant activity,and amelioration of type 2 diabetes... Lupeol(LUP)is a natural triterpenoid compound derived from various plants,exhibiting pharmacological effects including tumor inhibition,inflammation suppression,antioxidant activity,and amelioration of type 2 diabetes mellitus.In terms of anti-tumor activity,LUP inhibits breast cancer by inducing ROS accumulation,suppresses liver cancer by inhibiting the Wnt/β-catenin pathway,exerts anti-lung cancer effects by regulating the Notch pathway,and blocks the colon cancer cell cycle by inhibiting the RhoA-ROCK1 pathway.In terms of anti-inflammatory activity,LUP alleviates osteoarthritis by activating the SIRT3/mTOR pathway to enhance autophagy.In terms of antioxidant activity,LUP alleviates oxidative stress and inflammation to protect against myocardial injury.Additionally,LUP improves type 2 diabetes mellitus by regulating glucose and lipid metabolism and protecting isletβ-cells.LUP has high safety and multi-target regulatory effects.However,its specific molecular mechanisms and clinical studies still require further in-depth exploration. 展开更多
关键词 Lupeol Anti-tumor Anti-inflammatory Antioxidant Type 2 diabetes mellitus
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Analgesic,Anti-tumor,Antiarrhythmic,Anti-inflammatory,and CNS Inhibitory Activities of Oxysophoridine 认领 引用
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作者 Linbo JIA Huizhen PEI +3 位作者 Jiaru YE Shuang REN Hongye LI Chenghao JIN 《Medicinal Plant》 2026年第4期37-39,共3页
This paper review summarizes the analgesic,anti-tumor,antiarrhythmic,anti-inflammatory,and CNS inhibitory activities of oxysophoridine,along with their underlying molecular mechanisms.In terms of analgesic activity,ox... This paper review summarizes the analgesic,anti-tumor,antiarrhythmic,anti-inflammatory,and CNS inhibitory activities of oxysophoridine,along with their underlying molecular mechanisms.In terms of analgesic activity,oxysophoridine exerts pain relieving effects by enhancing GABAergic inhibitory function.Regarding anti-tumor activity,its combination with salvianolic acid A can synergistically block the cell cycle,induce apoptosis,and inhibit the proliferation of cervical precancerous cells.With respect to antiarrhythmic activity,it acts through non specific antagonism of the adrenergic system and blockade of sodium ion influx.As for anti-inflammatory activity,it downregulates CD14/TLR4 expression,inhibits pathways such as NF-κB,and reduces the release of inflammatory cytokines.Furthermore,in its CNS inhibitory activity,it dose-dependently suppresses spontaneous locomotor activity in mice and synergistically enhances hypnotic effects.This review provides a theoretical basis for the further development and clinical application of oxysophoridine. 展开更多
关键词 Oxysophoridine Analgesic activity Anti-tumor activity Antiarrhythmic activity Anti-inflammatory activity CNS inhibitory activity
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Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users 认领 引用
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作者 Ning-Hui Zhao Ling-Ran Zhao +4 位作者 Jia Yao Ling-Yun Niu Long-Jun Yang Yu-Jia Lin Mei Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第2期279-289,共11页
BACKGROUND Despite the enhanced detection capability of capsule endoscopy for small intestinal lesions,the independent risk factors and distinct clinical-endoscopic characteristics in high-risk populations remain inco... BACKGROUND Despite the enhanced detection capability of capsule endoscopy for small intestinal lesions,the independent risk factors and distinct clinical-endoscopic characteristics in high-risk populations remain incompletely elucidated.AIM To investigate the risk factors for small intestinal mucosal injury(SIMI)in nonsteroidal anti-inflammatory drug(NSAID)users and to establish a corresponding predictive model.METHODS We conducted a retrospective analysis of clinical data from patients undergoing capsule endoscopy at our institution and Shanxi Bethune Hospital from August 2012 to January 2025.Multivariate analysis was performed to identify independent risk factors for SIMI.A nomogram was subsequently developed to predict the risk of SIMI in NSAID users.Receiver operating characteristic curve analysis,calibration curve and decision curve analysis were performed to evaluate the predictive accuracy of the nomogram.RESULTS In the primary cohort,SIMI was identified in 114 out of 181 NSAID users.Multivariate analysis revealed that advanced age,smoking,proton pump inhibitor use,elevated body mass index,high triglyceride levels,and increased low-density lipoprotein were independent risk factors for SIMI.The research team developed a risk prediction model for estimating the risk of mucosal injury,which achieved an area under the curve of 0.775(95%confidence interval:0.700-0.849)in the derivation set.The model exhibited an area under the curve of 0.797(95%confidence interval:0.643-0.952)in the validation cohort.CONCLUSION We identified risk factors for SIMI in NSAID users and established a predictive model,which may facilitate early identification of high-risk populations and guide clinical interventions. 展开更多
关键词 Small intestinal mucosal injury Nonsteroidal anti-inflammatory drug Capsule endoscopy Risk factors Prediction model
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Isolation,Identification,and Anti-inflammatory Activity of Human-derived Staphylococcus epidermidis 认领 引用
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作者 Ye Lin Wu Qiting +1 位作者 Nie Yanfeng Guo Chaowan 《China Detergent & Cosmetics》 CAS 2026年第2期69-75,共7页
To investigate the intervention effect of human-derived Staphylococcus epidermidis on skin inflammation,thirty-seven skin swab samples were collected from the Guangzhou,China.Strains of Staphylococcus were isolated an... To investigate the intervention effect of human-derived Staphylococcus epidermidis on skin inflammation,thirty-seven skin swab samples were collected from the Guangzhou,China.Strains of Staphylococcus were isolated and purified using selective culture media,followed by species identification through 16S rRNA sequencing and phylogenetic tree construction.The antioxidant activity of the isolated strains was assessed via antioxidant assays.Furthermore,an inflammatory model with high pyroptosis expression in BJ cells was established using lipopolysaccharide(LPS)induction to evaluate the inhibitory effect of the isolates on the pyroptosis pathway.A strain of human-derived Staphylococcus epidermidis was isolated and named M-5Y.Following fermentation,the resulting supernatant exhibited potent free radical scavenging capacity against both DPPH and ABTS,indicating substantial antioxidant activity.Furthermore,the M-5Y supernatant significantly suppressed the activation of the pyroptosis pathway in BJ cells triggered by LPS,demonstrating notable anti-inflammatory efficacy. 展开更多
关键词 Staphylococcus epidermidis anti-inflammatory antioxidant skin
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Characteristic Chromatogram of Yao Medicine Kadsura longipedunculata and the Analysis of Its Anwulignan Content and Anti-inflammatory Activity 认领 引用
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作者 Binglan TANG Wei GAO +4 位作者 Chengjian ZHAO Chunli OU Xiaoli HOU Lu CHEN Dandan MO 《Medicinal Plant》 2026年第3期30-35,共6页
[Objectives]To establish a characteristic chromatogram of the traditional Yao medicine Kadsura longipedunculata,develop a method for quantifying its primary component,anwulignan,and evaluate the anti-inflammatory acti... [Objectives]To establish a characteristic chromatogram of the traditional Yao medicine Kadsura longipedunculata,develop a method for quantifying its primary component,anwulignan,and evaluate the anti-inflammatory activity of anwulignan.[Methods]Gradient elution was performed using high-performance liquid chromatography(HPLC)with a mobile phase consisting of acetonitrile and 0.5%phosphoric acid solution.A characteristic chromatogram of K.longipedunculata was established,and its similarity was assessed using the Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(2012 Edition).Additionally,the content of anwulignan in K.longipedunculata was quantified.Lipopolysaccharide-induced RAW264.7 macrophages were employed as an inflammatory cell model to investigate the effects of anwulignan on the levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)in the cell culture supernatant.[Results]The similarity indices of characteristic chromatograms for 10 batches of K.longipedunculata ranged from 0.901 to 0.994,with 9 common peaks identified.Among these,three components were characterized,including changnan schisantherin E,kadsulactone A,and anwulignan.The content of anwulignan was quantified as ranging from(0.72±0.05)to(1.21±0.03)mg/g(n=3).Furthermore,anwulignan at concentrations of 0.125-0.5μg/mL significantly reduced the levels of TNF-α,IL-1β,and IL-6 in the supernatant of inflammatory model cells(P<0.05 or P<0.01).[Conclusions]HPLC characteristic chromatogram of K.longipedunculata and the method for determining the content of anwulignan have been established.Anwulignan may represent the active ingredient responsible for the anti-inflammatory effects observed in K.longipedunculata. 展开更多
关键词 Yao medicine Kadsura longipedunculata HPLC Characteristic chromatogram Quality control Anwulignan Anti-inflammatory action
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Anti-inflammatory and Deodorizing Effects and Mechanisms of Action of Traditional Chinese Medicine Formulations:A Network Pharmacology Approach 认领 引用
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作者 Yingbing HE Yi WU Quan SHI 《Medicinal Plant》 2026年第3期39-46,共8页
[Objectives]To investigate the material basis and underlying mechanisms by which topical traditional Chinese medicine(TCM)alleviates odor issues in the vulvar region associated with inflammatory responses.[Methods]The... [Objectives]To investigate the material basis and underlying mechanisms by which topical traditional Chinese medicine(TCM)alleviates odor issues in the vulvar region associated with inflammatory responses.[Methods]The active components and their corresponding targets were identified through screening using the TCMSP database,HIT 2.0 database,and NetInfer.The UniProt database was utilized to standardize the name of the collected targets.Subsequently,an intersection analysis was conducted with targets obtained from the GeneCards database to determine the anti-inflammatory targets of the TCM formulation under investigation.A network diagram illustrating the relationships among TCM,its bioactive components,and their corresponding targets was constructed using Cytoscape software,followed by topological analysis.Additionally,a protein-protein interaction(PPI)network was developed and analyzed utilizing the STRING database in conjunction with Cytoscape.Gene Ontology(GO)enrichment analysis of the targets was performed employing the DAVID database.[Results]A total of 76 active compounds were identified from the TCM formulation through screening,corresponding to 662 targets.Subsequent analysis revealed 62 core targets associated with vaginitis and urethritis.Network diagram analysis indicated that the principal Chinese herbs in this formulation were Sophorae Flavescentis Radix,Herba Leonuri,and Eupatorium fortunei.The formulation may exert anti-inflammatory and deodorizing effects via bioactive compounds such as quercetin,apigenin,and genistein,while simultaneously mitigating inflammatory responses by modulating target proteins including ALB,IL6,TNF,IL-1β,and IFNG.[Conclusions]The TCM formulation has the potential to mitigate inflammatory responses and diminish the odor of secretions through multi-component and multi-target mechanisms.Due to their capacity to mask flavors,inhibit bacterial growth,and reduce inflammation,medicinal plants hold significant research and practical value in the domain of odor control. 展开更多
关键词 Traditional Chinese medicine(TCM)formulation Anti-inflammatory Vulvar odor Network pharmacology
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Application of Moxibustion Combined with Sihuang Anti-inflammatory Lotion in a BMT Patient with Herpes Zoster 认领 引用
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作者 Suling Chen Zhongren Chen Jiaqian Cai 《Journal of Clinical and Nursing Research》 2026年第2期47-55,共9页
Objective: To explore the application effect of moxibustion combined with Sihuang Anti-inflammatory Lotion in patients with herpes zoster after bone marrow transplantation (BMT). Methods: One patient with herpes zoste... Objective: To explore the application effect of moxibustion combined with Sihuang Anti-inflammatory Lotion in patients with herpes zoster after bone marrow transplantation (BMT). Methods: One patient with herpes zoster after BMT was selected and treated with moxibustion combined with Sihuang Anti-inflammatory Lotion in addition to conventional antiviral drugs. Results: The patient’s pain disappeared within 48 hours after the intervention (NRS score decreased from 6 to 2), large-scale crusting of herpes occurred within 72 hours, and complete shedding occurred within 10 days. No infection or other adverse reactions occurred, and the patient had high nursing satisfaction. Conclusion: Moxibustion combined with Sihuang Anti-inflammatory Lotion can safely and effectively improve the symptoms of herpes zoster after BMT, which is worthy of clinical promotion. 展开更多
关键词 Bone marrow transplantation Herpes zoster Moxibustion Sihuang Anti-inflammatory lotion
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Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica 认领 引用 被引量：4
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作者 Juan Zhang Jiankun Yan +7 位作者 Hongjun Dong RuiZhang Jing Chang Yanli Feng Xinrong Xu Wei Li Feng Qiu Chengpeng Sun 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第8期961-971,共11页
In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed ... In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids,an activity-guided fractionation approach utilizing lipopolysaccharide(LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from Inula Britannica(I.britannica).Seven novel sesquiterpenoid dimers inulabritanoids A−G(1−7)and two novel sesquiterpenoid monomers inulabritanoids H(8)and I(9)were isolated from I.britannica together with eighteen known compounds(10−27).The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance(NMR),high-resolution mass spectrometry(HR-MS),and electronic circular dichroism(ECD)spectra,complemented by quantum chemical calculations.Compounds 1,2,12,16,19,and 26 demonstrated inhibitory effects on NO production,with IC50 values of 3.65,5.48,3.29,6.91,3.12,and 5.67μmol·L−1,respectively.Mechanistic studies revealed that compound 1 inhibited IκB kinaseβ(IKKβ)phosphorylation,thereby blocking nuclear factorκB(NF-κB)nuclear translocation,and activated the kelch-like ECH-associated protein 1(Keap1)uclear factor erythroid 2-related factor 2(Nrf2)signal pathway,leading to decreased expression of NADPH oxidase 2(NOX-2),inducible nitric oxide synthase(iNOS),tumor necrosis factorα(TNF-α),interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),IL-1β,and IL-1αand increased expression of NAD(P)H:quinone oxidoreductase 1(NQO-1)and heme oxygenase-1(HO-1),thus exhibiting anti-inflammatory effects in vitro.These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development. 展开更多
关键词 Inula britannica Sesquiterpenoid dimers Anti-inflammatory effects Mechanism Keap1-Nrf2
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Biological activity analysis of baicalin nanodrugs:Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia 认领 引用 被引量：2
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作者 Chenqi Chang Chang Lu +5 位作者 Yu Zheng Lili Lin XiuZhen Chen Linwei Chen Zhipeng Chen Rui Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第7期1619-1633,共15页
Respiratory syncytial virus(RSV)is a ubiquitous respiratory virus that affects individuals of all ages;however,there is a notable lack of targeted treatments.RSV infection is associated with a range of respiratory sym... Respiratory syncytial virus(RSV)is a ubiquitous respiratory virus that affects individuals of all ages;however,there is a notable lack of targeted treatments.RSV infection is associated with a range of respiratory symptoms,including bronchiolitis and pneumonia.Baicalin(BA)exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action.Nonetheless,the clinical application of BA is constrained by its low solubility and bioavailability.In this study,we prepared BA nanodrugs(BA NDs)with enhanced water solubility utilizing the supramolecular self-assembled strategy,and we further conducted a comparative analysis of this pharmacological activity between free drugs and NDs of BA.Both in vitro and in vivo results demonstrated that BA NDs significantly enhanced the dual effects of viral inhibition and inflammation relief compared to free BA,attributed to prolonged lung retention,improved cellular uptake,and increased targeting affinity.Our study confirms that the nanosizing strategy,a straightforward approach to enhance drug solubility,can also increase biological activity compared to free drugs with the same content,thereby providing a potential ND for RSV treatment.This correlation analysis between the existing forms of drugs and their biological activity offers a novel perspective for research on the active ingredients of traditional Chinese medicine. 展开更多
关键词 Respiratory syncytial virus Baicalin Nanodrugs Biological activity analysis Antiviral Anti-inflammatory
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Thymus serpyllum L.Essential Oil:Phytochemistry and in Vitro and in Silico Screening of Its Antimicrobial,Antioxidant and Anti-Inflammatory Properties 认领 引用 被引量：2
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作者 Samiah Hamad Al-Mijalli Hanae Naceiri Mrabti +9 位作者 Amine Elbouzidi Naglaa S.Ashmawy Amine Batbat Emad M.Abdallah Wafa Laaboudi Mohammed Aladhadh Fahad M.Alshabrmi Sulaiman Mohammed Alnasser Mohamed Addi Naoufal El Hachlafi 《Phyton-International Journal of Experimental Botany》 SCIE 2025年第1期209-227,共19页
Thymus serpyllum L.,often known as wild thyme,has been used since ancient times due to its multifaceted culinary and medicinal attributes.It is usually utilized in folk medicine to manage different health issues.This ... Thymus serpyllum L.,often known as wild thyme,has been used since ancient times due to its multifaceted culinary and medicinal attributes.It is usually utilized in folk medicine to manage different health issues.This work aimed to investigate the chemical composition and biological characteristics of T.serpyllum essential oil(EO),including its antimicrobial,antioxidant,and anti-inflammatory capabilities.Moreover,we have prompted an in-silico simulation to reveal the underlying mode of action of these properties.The chemical characterization of T.serpyllum(EO)by Gas Chromatography-Mass Spectrometry(GC-MS)indicated sabinene(17.33%),terpinen-4-ol(11.73%),phellandral(13.18%),and thymol(10.54%)as main components.The antimicrobial screening utilized the disc-diffusion technique,MIC,and MBC assays.The disc-diffusion test’s results revealed significant anti-Candida activity and notable antibacterial efficacy.The MIC and MBC tests showed that T.serpyllum EO effectively stops bacterial growth,including Gram-positive and Gram-negative strains and Candida strains.The tolerance level ratio demonstrated that this EO exhibits bactericidal and fungicidal effects on all tested bacteria and Candida strains.Also,T.serpyllum EO presented effective inhibitory activity against the 5-lipoxygenase(5-LOX)enzyme(IC50=744.19±0.1µg/mL)(p<0.05).It also effectively affected FRAP,β-carotene,DPPH,and ABTS radicals.In light of these findings,T.serpyllum holds promise for diverse applications across pharmaceuticals,nutraceuticals,and the food industry.However,further research and collaboration between traditional knowledge and modern medicine are crucial to fully realizing its potential benefits in these fields. 展开更多
关键词 Thymus serpyllum GC-MS antimicrobial oxidative stress anti-inflammatory in silico
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Integrated anti-inflammatory and anti-fibrosis dual drug-loaded core-shell fiber scaffolds:Diabetic wound healing and scar reduction 认领 引用 被引量：1
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作者 Jing Wen Xue Luo +4 位作者 Huan Liu Tingting Ma Jiangshan Liu Yubao Li Jidong Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第34期155-170,共16页
Scarring poses a significant challenge in wound healing,especially for chronic wounds like those linked to diabetes.This study developed a dual drug-loaded core-shell fiber scaffold(PSPC)containing curcumin(Cur)in the... Scarring poses a significant challenge in wound healing,especially for chronic wounds like those linked to diabetes.This study developed a dual drug-loaded core-shell fiber scaffold(PSPC)containing curcumin(Cur)in the shell and salvianolic acid B(SAB)in the core via electrospinning to address this challenging issue through synergistic anti-inflammatory and anti-fibrosis efficacy.The PSPC scaffold presented favorable tensile properties(3.78±0.29 MPa of tensile strength and 337.64%±32.07%of elongation at break)and suture retention(2.71±0.17 N).In vitro experiments confirmed that this scaffold was biocompatible,supporting cell adhesion and proliferation.Additionally,it also scavenged excessive intracellular reactive oxygen species(ROS)and promoted macrophage polarization towards the regenerative M2 phenotype.In vivo studies using a mouse diabetic wound model showed that the PSPC scaffold effectively mitigated inflammatory responses,promoted neoangiogenesis,and facilitated epidermal formation and re-epithelialization.More importantly,the scaffold also modulated collagen synthesis,decreased the collagen type Ⅰ/Ⅲ ratio,supported the functional regeneration of hair follicles,sebaceous glands,and other skin appendages,then ultimately achieved the goal of chronic diabetic wound healing and scar reduction.The developed dual drug-loaded fiber scaffold integrating anti-inflammatory and anti-fibrosis presents a promising strategy for the anti-scarring treatment of chronic wounds. 展开更多
关键词 Electrospinning Anti-inflammatory Anti-scarring Diabetic wound healing
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