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Novel and Simple Strategy for Marine Fish Preservation Using Attapulgite Clay-Cinnamon Essential Oil Composite:Characterization,Antibacterial Activity and Application 认领 引用
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作者 YANG Jiawei TANG Haiqing +4 位作者 DU Yingqi HUANG Tao YANG Wenge WEI Huamao OU Changrong 《Journal of Ocean University of China》 SCIE CAS CSCD 2026年第2期626-638,I0018-I0020,共13页
To explore the potential of essential oil(EO)in preserving marine fish,cinnamon essential oil(CEO)was loaded onto attapulgite clay(ATP)to form a stable composite.The characteristics,antimicrobial activity,and efficacy... To explore the potential of essential oil(EO)in preserving marine fish,cinnamon essential oil(CEO)was loaded onto attapulgite clay(ATP)to form a stable composite.The characteristics,antimicrobial activity,and efficacy of this composite in application in fish preservation were evaluated.The results showed that the EO was bound to the ATP surface through intermolecular interaction forces.The results of the in vitro testing demonstrated that the ATP-CEO composite exhibited a strong and sustained antibacterial activity.Assessed by total volatile basic nitrogen analysis,the ATP-CEO preservation film extended the shelf life of sea bass from4 to 10 days and that of salmon from 6 to 14 days.Meanwhile,the quality indexes,such as texture and water-holding capacity of the fish,were significantly better(p<0.05)than those of the control group.Overall,the results indicated that the ATP-CEO composite has the potential to be a sustainable natural preservation method for the storage and preservation of sea bass and salmon fillets. 展开更多
关键词 fish preservation cinnamon essential oil attapulgite clay antibacterial activity quality retention
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Silver chloride/chitosan‑based chloramine nanohybrid with excellent antibacterial activity:Design and structure characterization as well as Ag+‑Cl-synergistic antibacterial effect 认领 引用
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作者 ZHANG Xinzhe XU Jiarong +4 位作者 GAO Mochou LIU Yage ZHAO Yanbao CUI Jingzeng ZOU Xueyan 《无机化学学报》 SCIE CAS CSCD 北大核心 2026年第2期428-438,共11页
Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO2‑NH2)cores to obtain AgCl@SiO2/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO2/CTS nanoparticle... Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO2‑NH2)cores to obtain AgCl@SiO2/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO2/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO2/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO2/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO2/CTS and AgCl@SiO2/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH2,the antibacterial mechanism of AgCl@SiO2/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO2/CTS and AgCl@SiO2/CTS‑Cl.Findings demonstrate that sample AgCl@SiO2/CTS exhibits a chain‑like structure ascribed to the interaction between—NH2,and each AgCl@SiO2/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO2/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag+and Cl-.Sample AgCl@SiO2/CTS‑Cl with a dosage of 640.00μg·mL-1 could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests. 展开更多
关键词 AgCl@SiO2/CTS‑Cl hybrid nanoparticle synergistic effect antibacterial activity
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Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus 认领 引用 被引量:1
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作者 Qingqing Chen Yuhang Ding +13 位作者 Zhongyi Li Xingyu Chen Aliya Fazal Yahan Zhang Yudi Ma Changyi Wang Liu Yang Tongming Yin Guihua Lu Hongyan Lin Zhongling Wen Jinliang Qi Hongwei Han Yonghua Yang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第5期604-613,共10页
Given the increasing concern regarding antibacterial resistance,the antimicrobial properties of naphthoquinones have recently attracted significant attention.While 1,4-naphthoquinone and its derivatives have been exte... Given the increasing concern regarding antibacterial resistance,the antimicrobial properties of naphthoquinones have recently attracted significant attention.While 1,4-naphthoquinone and its derivatives have been extensively studied,the antibacterial properties of 5,8-dihydroxy-1,4-naphthoquinone derivatives remain relatively unexplored.This study presents a comprehensive in vitro and in vivo analysis of the antibacterial activity of 35 naturally sourced and chemically synthesized derivatives of 5,8-dihydroxy-1,4-naphthoquinone.Kirby-Bauer antibiotic testing identified three compounds with activity against methicillin-resistant Staphylococcus aureus(MRSA),with one compound(PNP-02)demonstrating activity comparable to vancomycin in minimum inhibitory concentration,minimum bactericidal concentration(MBC),and time-kill assays.Microscopic and biochemical analyses revealed that PNP-02adversely affects the cell wall and cell membrane of MRSA.Mechanistic investigations,including proteomic sequencing analyses,Western blotting,and RT-q PCR assays,indicated that PNP-02 compromises cell membrane integrity by inhibiting arginine biosynthesis and pyrimidine metabolism pathways,thereby increasing membrane permeability and inducing bacterial death.In an in vivo mouse model of skin wound healing,PNP-02 exhibited antibacterial efficacy similar to vancomycin.The compound demonstrated low toxicity to cultured human cells and in hemolysis assays and remained stable during serum incubation.These findings suggest that PNP-02 possesses promising bioactivity against MRSA and represents a potential novel antibacterial agent. 展开更多
关键词 5,8-Dihydroxy-1,4-naphthoquinone Antibacterial activity MRSA Arginine biosynthesis Pyrimidine metabolism
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Synergistic Antibacterial Activity of Fe3O4@mPEG-Ag Nanoparticles with Molecular Docking Analyses 认领 引用 被引量:1
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作者 Basit Ali Shah Hongguo Zhu +6 位作者 Asma Sardar Yuan Gu Syed Taj Ud Din Kashif Naseem Xinyan Wu Bin Yuan Bin Yang 《Biomedical Engineering Frontiers》 EI CAS 2025年第1期1-22,共22页
Objective:This study aims to develop methoxy poly(ethylene glycol)(mPEG)and silver-modified magnetite nanoparticles termed Fe3O4@mPEG-Ag NPs as efficient non-antibiotic antibacterial agents to address the growin... Objective:This study aims to develop methoxy poly(ethylene glycol)(mPEG)and silver-modified magnetite nanoparticles termed Fe3O4@mPEG-Ag NPs as efficient non-antibiotic antibacterial agents to address the growing challenge of drug-resistant bacterial infections.Impact Statement:This work demonstrates a synergistic nanomaterial design that achieves high antibacterial efficacy,stability,and biocompatibility,positioning it as a promising alternative to conventional antibiotics in combating antimicrobial resistance.Introduction:Infectious diseases caused by drug-tolerant bacteria present a serious global health risk.Fe3O4@mPEG-Ag NPs were developed as synthetic bactericides that integrate the antibacterial properties of Ag with an excellent stability and dispersibility of mPEG-modified Fe3O4.Methods:Fe3O4@mPEG-Ag NPs were fabricated via a serial coprecipitation technique.A series of structural and functional characterizations was performed,and antibacterial activity was tested.Additional assessments included minimum inhibitory concentration(MIC)determination,detailed mechanistic evaluation,cytocompatibility assays,and in silico molecular docking studies.Results:Fe3O4@mPEG-Ag NPs demonstrate superior antibacterial activity at a MIC as low as 50μg·ml−1 and achieved an efficacy similar to ciprofloxacin.The improved bactericidal effect is attributed to strong electrostatic interactions,membrane disruption through enhanced reactive oxygen species generation under visible light,and intracellular damage via NP penetration and controlled Ag+leaching.Surface functionalization improves colloidal stability and bioactivity while simultaneously maintaining>80%cell viability.Molecular docking further supports the experimental findings by confirming the inhibition of Staphylococcus aureus DNA gyrase and Escherichia coliβ-lactamase enzymes.Conclusion:Fe3O4@mPEG-Ag NPs demonstrate synergistic antibacterial mechanisms with high biocompatibility,highlighting their potential as effective nanotherapeutics for bacterial control,and represent a promising alternative to conventional antibiotics to combat antimicrobial resistance. 展开更多
关键词 synergistic nanomaterial design biocompatibility molecular docking nanomaterial design synergistic antibacterial activity Fe O mpeg ag nanoparticles antibacterial efficacy antimicrobial resistance
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Praseodymium-organic framework with 4,4′-oxybis(benzoic acid):Rare broken layer structure,antibacterial activity,and sensing for Cd2+ions 认领 引用
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作者 CUI Peipei ZHENG Yawen +2 位作者 LI Pan GUAN Peiyan QIAN Zhaohong 《无机化学学报》 SCIE CAS CSCD 北大核心 2025年第8期1641-1649,共9页
A novel 3D metal-organic framework(MOF)[Pr2(L)3(H2O)5·H2O]n(Pr-1),(H2L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal sy... A novel 3D metal-organic framework(MOF)[Pr2(L)3(H2O)5·H2O]n(Pr-1),(H2L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal synthesis.The struc-ture and crystal net were analyzed and characterized.This rod net of Pr-1 is new to both RCSR and ToposPro data-bases,and is named as rn-12 as suggested.Due to the luminescent properties of H2L and Pr(Ⅲ),the solid-state fluo-rescence property and sensing performance(solvents and metal ions)of Pr-1 were investigated.The sensing experi-ments indicated that Pr-1 could act as a fluorescence sensor to detect Cd2+ions with good sensitivity.In addition,antibacterial activities show that Pr-1 exhibited stronger antibacterial activity against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and Bacillus subtilis(B.subtilis)compared to synthetic materials. 展开更多
关键词 dicarboxylate ligand crystal net luminescence sensing antibacterial activity
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Crystal structure and antibacterial activity of two Gd2complexes based on polydentate Schiff-base ligands 认领 引用 被引量:3
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作者 ZHANG Yingyue KANG Liuqing +2 位作者 YANG Yating GUAN Xiaofen WANG Wenmin 《无机化学学报》 SCIE CAS CSCD 北大核心 2025年第9期1867-1877,共11页
Two Gd2complexes,namely[Gd2(dbm)2(HL1)2(CH3OH)2]·4CH3OH(1)and[Gd2(dbm)2(L2)2(CH3OH)2]·2CH3OH(2),where H3L1=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene... Two Gd2complexes,namely[Gd2(dbm)2(HL1)2(CH3OH)2]·4CH3OH(1)and[Gd2(dbm)2(L2)2(CH3OH)2]·2CH3OH(2),where H3L1=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide,H2L2=(E)-N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide,Hdbm=dibenzoylmethane,have been constructed by adopting the solvothermal method.Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd3+ions,two dbm-ions,two CH3OH molecules,and two polydentate Schiff-base ligands(HL12-or L22-).In addition,complex 1 contains four free methanol molecules,whereas complex 2 harbors two free methanol molecules.By investigating the interactions between complexes 1 and 2 and four types of bacteria(Bacillus subtilis,Escherichia coli,Staphylococcus aureus,Candida albicans),it was found that both complexes 1 and 2 exhibited potent antibacte-rial activities.The interaction mechanisms between the ligands H3L1,H2L2,complexes 1 and 2,and calf thymus DNA(CT-DNA)were studied using ultraviolet-visible spectroscopy,fluorescence titration,and cyclic voltammetry.The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules,thereby inhibiting bacterial proliferation to achieve the antibacterial effects.CCDC:2401116,1;2401117,2. 展开更多
关键词 Gd2complex polydentate Schiff base crystal structure DNA interaction antibacterial activity
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Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism 认领 引用 被引量:143
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作者 Amna Sirelkhatim Shahrom Mahmud +5 位作者 Azman Seeni Noor Haida Mohamad Kaus Ling Chuo Ann Siti Khadijah Mohd Bakhori Habsah Hasan Dasmawati Mohamad 《Nano-Micro Letters》 SCIE EI CAS 2015年第3期219-242,共24页
Antibacterial activity of zinc oxide nanoparticles(Zn O-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many micro... Antibacterial activity of zinc oxide nanoparticles(Zn O-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Zn O-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. Zn O is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered Zn O-NPs antibacterial activity including testing methods, impact of UV illumination, Zn O particle properties(size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species(ROS) including hydrogen peroxide(H2O2), OH-(hydroxyl radicals), and O2-2(peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to Zn O-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions.These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on Zn O abrasive surface texture. One functional application of the Zn O antibacterial bioactivity was discussed in food packaging industry where Zn O-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of Zn O-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition. 展开更多
关键词 Antibacterial activity Zn O-NPs Toxicity mechanism Reactive oxygen species Zinc ions release Food antimicrobial
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Bioactivity,in-vitro corrosion behavior,and antibacterial activity of silver-zeolites doped hydroxyapatite coating on magnesium alloy 认领 引用 被引量:12
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作者 H.R.BAKHSHESHI-RAD E.HAMZAH +3 位作者 A.F.ISMAIL M.AZIZ E.KARAMIAN N.IQBAL 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第8期1553-1562,共10页
Mg-based alloys received significant attention for temporary implant applications while, their applications have been limited by high degradation rate. Therefore, silver-zeolite doped hydroxyapatite(Ag-Zeo-HAp) coat... Mg-based alloys received significant attention for temporary implant applications while, their applications have been limited by high degradation rate. Therefore, silver-zeolite doped hydroxyapatite(Ag-Zeo-HAp) coating was synthesized on Ti O2-coated Mg alloy by physical vapour deposition(PVD) assisted electrodeposition technique to decrease the degradation rate of Mg alloy. X-ray diffraction(XRD) analysis and field emission scanning electron microscopy(FE-SEM) images showed the formation of a uniform and compact layer of Ag-Zeo-HAp with a thickness of 15 μm on the Ti O2 film with a thickness of 1 μm. The potentiodynamic polarization(PDP) and electrochemical impedance spectroscopy(EIS) tests indicated that corrosion resistance of Mg-Ca alloy was considerably increased by the Ag-Zeo-HAp coating. The bioactivity test in the simulated body fluid(SBF) solution showed that a dense and homogeneous bonelike apatite layer was formed on the Ag-Zeo-HAp surface after 14 d. Investigation of antibacterial activity via disk diffusion and spread plate methods showed that the Ag-Zeo-HAp coating had a significantly larger inhibition zone(3.86 mm) towards Escherichia coli(E. coli) compared with the Ti O2-coated Mg alloy(2.61 mm). The Ag-Zeo-HAp coating showed high antibacterial performance, good bioactivity, and high corrosion resistance which make it a perfect coating material for biomedical applications. 展开更多
关键词 magnesium alloy zeolite coatiilg bioactivity conosion behavior antibacterial activity
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Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks(Poephagus grunniens)with haemorrhagic diarrhoea 认领 引用 被引量:13
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作者 Samiran Bandyopadhyay Pabitra H Patra +9 位作者 Achintya Mahanti Dipak K Mondal Premanshu Dandapat Subhasis Bandyopadhyay Indranil Samanta Chandan Lodh Asit K Bera Debasish Bhattacharyya Mihir Sarkar Kishore K Baruah 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第4期315-319,共5页
Objective:To evaluate the antimicrobial efficacy of berberine,a plant alkaloid.Methods:Five multi-drug resistant(MDR)STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the stu... Objective:To evaluate the antimicrobial efficacy of berberine,a plant alkaloid.Methods:Five multi-drug resistant(MDR)STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the study.Antibacterial activity of berberine was evaluated by broth dilution and disc diffusion methods.The binding kinetics of berberine to DNA and protein was also enumerated.Results:For both categories of enterovirulent Escherichia coli(E.roli)isolates,berberine displayed the antibaclerial effect in a dose dependent manner.The MIC50of berberine chloride for STEC/EPEC isolates varied from 2.07μM to 3.6μM with a mean of(2.95±0.33)μM where as for ETEC strains it varied from 1.75 to 1.96μM with a mean of(1.87±0.03)μM.Berberine bind more tightly with double helix DNA with Bmax and Kd of(24.68±2.62)and(357.8±57.8),respectively.Berberine reacted with protein in comparatively loose manner with Bmax and Kd of(18.9±3.83)and【286.2±113.6),respectively.Conclusions:The results indicate clearly that berberine may serve as a good antibacterial against multi drug resistant E.coli. 展开更多
关键词 Berberine Multidrug resistant enterovirulent Escherichia coli Haemorrhagic diarrhoea Antibacterial activity Yak
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Au nanorods decorated TiO2nanobelts with enhanced full solar spectrum photocatalytic antibacterial activity and the sterilization file cabinet application 认领 引用 被引量:11
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作者 Yingying Qin Yichen Guo +4 位作者 Zhangqian Liang Yanjun Xue Xiaoli Zhang Lei Yang Jian Tian 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第4期1523-1526,共4页
TiO2photocatalysts have been widely studied and applied for removing bacteria,but its antibacterial efficiency is limited to the ultraviolet(UV)range of the solar spectrum.In this work,we use the gold(Au)nanorods t... TiO2photocatalysts have been widely studied and applied for removing bacteria,but its antibacterial efficiency is limited to the ultraviolet(UV)range of the solar spectrum.In this work,we use the gold(Au)nanorods to enhance the visible and near-infrared(NIR)light absorption of TiO2NBs,a typical UV light photocatalyst,thus the enhancement of its full solar spectrum(UV,visible and NIR)photocatalytic antibacterial properties is achieved.Preliminary surface plasmon resonance(SPR)enhancement photocatalytic antibacterial mechanism is suggested.On one hand,transverse and longitudinal SPR of Au NRs is beneficial for visible and NIR light utilization.On the other hand,Au NRs combined with TiO2NBs to form the heterostructure,which can improve the photogenerated carrier separation and direct electron transfer increases the hot electron concentration while Au NRs as the electron channel can well restrain charge recombination.finally produces the high yield of radical oxygen species and exhibits a superior antibacterial efficiency.Furthermore,we design a sterilization file cabinet with Au NR/TiO2NB heterostructures as the photocatalytic coating plates.Our study reveals that Au NR/TiO2NB heterostructure is a potential candidate for sterilization of bacteria and archives protection. 展开更多
关键词 Au nanorods TiO2nanobelts Photocatalytic antibacterial activity Surface plasmon resonance Sterilization file cabinet
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Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity 认领 引用 被引量:8
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作者 GAO Yu ZHAO Hong Lei +5 位作者 FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第4期319-322,共4页
Antimicrobial peptides (AMPs) are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics.
关键词 Design hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity Expression of Recombinant Human Lysozyme-tachyplesin I TP
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Preparation and Characterization of Nano-silver Loaded Montmorillonite with Strong Antibacterial Activity and Slow Release Property 认领 引用 被引量:8
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作者 Guangnian Xu Xueliang Qiao +1 位作者 Xiaolin Qiu Jianguo Chen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2011年第8期685-690,共6页
Nano-silver loaded montmorillonite (Ag-MMT) was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The m... Nano-silver loaded montmorillonite (Ag-MMT) was prepared by ion-exchange and then a UV-photoreduction two-step approach was applied. The silver content in Ag-MMT determined by Volhard method was about 6.4 wt%. The morphology and structure of as-synthesized Ag-MMT were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results showed that the Ag nanoparticles were spherical and their diameters were about 15-20 nm. Moreover, the structure of MMT did not change. The minimum inhibition concentration (MIC) of Ag-MMT was 100×10-6 and the sterilizing efficiency (SE) of Ag-MMT was approximately 100% against Escherichia coli ATCC 11229 (E. coli. In addition, the slow release property of silver in Ag-MMT was also demonstrated. 展开更多
关键词 Silver loaded montmorillonite Photoreduction Antibacterial activity Slow release property
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Structure and antibacterial activity of Ce3+exchanged montmorillonites 认领 引用 被引量:5
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作者 OUYANG Yousheng XIE Yushan +2 位作者 TAN Shaozao SHI Qingshan CHEN Yiben 《Journal of Rare Earths》 SCIE EI CAS 2009年第5期858-863,共6页
Four kinds of Ce3+exchanged montmorillonites(Ce/MMTs)were prepared by an ion-exchange reaction,and characterized with energy dispersive X-ray analysis(EDX),X-ray difference(XRD),X-ray photoelectron spectroscopy(XPS)an... Four kinds of Ce3+exchanged montmorillonites(Ce/MMTs)were prepared by an ion-exchange reaction,and characterized with energy dispersive X-ray analysis(EDX),X-ray difference(XRD),X-ray photoelectron spectroscopy(XPS)and scanning electron microscopy(SEM).The surface properties and antibacterial activity of Ce/MMTs were also investigated.The chemical compositions of Ce/MMTs were determined,and the cerium of Ce/MMTs was confirmed to be present as trivalent cerium state.The d001 basal spacings of Ce/MMTs were enlarged with the enhancement of the cerium contents,and the particles were formed with irregular shape.On increasing the Ce contents of Ce/MMTs,the special surface areas were decreased,but the total pore volumes and the average pore sizes were increased.The antibacterial activity of Ce/MMTs is increased with increasing the cerium contents,and 1.5 g/L of Ce/MMT-3 containing 11.46wt.%of curium could remove all the Staphylococcus aureus and more than 99.9%of the Escherichia coli within 24.0 h of contact.Moreover,Ce/MMTs displayed bactericidal activity. 展开更多
关键词 Ce3+exchanged montmorillonite chemical composition microstructure antibacterial activity rare earths
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(±)-Zanthonitidine A,a Pair of Enantiomeric Furoquinoline Alkaloids from Zanthoxylum nitidum with Antibacterial Activity 认领 引用 被引量:6
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作者 Li-Na Zhao Xi-Xi Guo +4 位作者 Shuai Liu Li Feng Qi-Rui Bi Zhe Wang Ning-Hua Tan 《Natural Products and Bioprospecting》 2018年第5期361-367,共7页
A pair of new enantiomeric furoquinoline alkaloids,(±)-zanthonitidine A(1),together with nine known ones(2-10)were isolated from the radix of Zanthoxylum nitidum.Their chemical structures were elucidated based on... A pair of new enantiomeric furoquinoline alkaloids,(±)-zanthonitidine A(1),together with nine known ones(2-10)were isolated from the radix of Zanthoxylum nitidum.Their chemical structures were elucidated based on the extensive spectroscopic analysis.The racemic mixture of 1 was separated by chiral column chromatography,and the absolute configurations of (+)-1 and(-)-1 were determined by the comparison of experimental and calculated electronic circular dichroism spectra.Antibacterial activities of compounds 1-9 were evaluated,and compounds(+)-1,(-)-1,3,7 and 8 showed antibacterial activities against Bacillus subtilis,Enterococcus faecalis or Staphylococcus aureus. 展开更多
关键词 Zanthoxylum nitidum Furoquinolinealk aloids Zanthonitidine A Antibacterial activity
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Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair:in vitro degradation,antibacterial activity and cytocompatibility evaluation 认领 引用 被引量:4
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作者 Yu-Lei Li Jin He +4 位作者 Hai-Xia Ye Can-Can Zhao Wei-Wei Zhu Xiong Lu Fu-Zeng Ren 《Rare Metals》 SCIE EI CAS CSCD 2022年第2期546-558,共13页
3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomi... 3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion. 展开更多
关键词 Atomic layer deposition Porous iron scaffolds ZnO Antibacterial activity
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Reduced graphene oxide (RGO) reinforced Mg biocomposites for use as orthopedic applications: Mechanical properties, cytocompatibility and antibacterial activity 认领 引用 被引量:6
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作者 Somayeh Abazari Ali Shamsipur HamidRezaBakhsheshi-Rad 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第12期3612-3627,共16页
Magnesium(Mg) has attracted wide interest in orthopedic applications as they exhibit great biodegradability and strong biocompatibility,while corrosion is the main concern for Mg that should be addressed prior to biom... Magnesium(Mg) has attracted wide interest in orthopedic applications as they exhibit great biodegradability and strong biocompatibility,while corrosion is the main concern for Mg that should be addressed prior to biomedical applications. In this work, ZM31(Mg-3Zn-1Mn)/x RGO(x = 0, 0.5, 1 and 1.5 wt%) biocomposites were synthesized by semi-powder metallurgy method. The results showed that the RGO acting as an effective reinforcing filler to prevent deformation and showed better compressive strength(282.3 ± 9 MPa) and revealed enhancement in failure Strain(7.8 ± 2.1%) at 1 wt% RGO concentration compared to Mg alloy(244.5 ± 9 MPa and 7.1 ± 1.5%respectively). Moreover, fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of RGO. Crack bridging, crack deflection and crack branching are dominant mechanisms for reinforcement of Mg-based containing RGO. Mg composites containing 0.5 wt% RGO showed a low corrosion rate(2.75 mm/year), while more incorporation of RGO resulted in an increased corrosion rate(4.38 mm/year). In addition, the degradation rate of ZM31 alloy(2.57 mg·cm-2·d-1) obviously decreased with the addition of 0.5 wt%RGO(1.84 mg·cm-2·d-1) in the SBF. Besides, continuous apatite layers were created on the composites in the SBF solution. Also, the cell culture examinations showed good cell viability and adhesion on composites with 0.5 and 1 wt% RGO, which was demonstrated by the SEM and MTT assay The alkaline phosphatase(ALP) activity of the ZM3–0.5RGO composite was considerably higher than that of ZM31matrix alloy in 24 h and 48 h, implying higher osteoblastic differentiation. The antibacterial behavior toward both bacteria(E. coli and S.aureus) exhibited that escalating RGO concentration in Mg-matrix composites leads to further inhibition of bacteria growth. These findings suggested that ZM31–0.5RGO biocomposite could be a more promising candidate for orthopedic implants. 展开更多
关键词 Mg alloys Reduced graphene oxide Mechanical properties Corrosion resistance Antibacterial activity Biocompatibility
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Synthesis and antibacterial activity of novel[1,2,4]triazolo[3,4-h][1,8]naphthyridine-7-carboxylic acid derivatives 认领 引用 被引量:3
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作者 Liu-Zhou Gao Yu-Suo Xie +2 位作者 Tao Li Wen-Long Huang Guo-Qiang Hu 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第1期149-151,共3页
Novel tricyclic fluoroquinolones,[1,2,4]triazolo[3,4-h][1,8]naphthyridine-8-one-7-carboxylic acid derivatives 4a-4h bearing carrying a functional Mannich-base moiety at the C-8 position,were synthesized and evaluated ... Novel tricyclic fluoroquinolones,[1,2,4]triazolo[3,4-h][1,8]naphthyridine-8-one-7-carboxylic acid derivatives 4a-4h bearing carrying a functional Mannich-base moiety at the C-8 position,were synthesized and evaluated for their antimicrobial activity.The results showed that some compounds with a piperazine side chain exhibited comparable or better antibacterial activity than comparator cirprofloxacin.Furthermore,the targeted compounds also displayed a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria.In particular,compound 4h showed an MIC of 0.25 μg/mL in antibacterial assay against multiple drug-resistant Escherichia coli,which represents an about 30-fold increase of potency compared to ciprofloxacin.Thus,their excellent antibacterial activity against resistant strains suggests that triazole-fused fluoroquinolones warrant further optimization as novel anti-infective chemotherapies. 展开更多
关键词 Triazole Tricyclic fluoroquinolone Synthesis Antibacterial activity
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Nano-silver-modified polyphosphazene nanoparticles with different morphologies:Design,synthesis,and evaluation of antibacterial activity 认领 引用 被引量:3
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作者 Tairong Kuang Linbing Deng +6 位作者 Sitao Shen Hongxia Deng Zhisen Shen Zhenjie Liu Zhengping Zhao Feng Chen Mingqiang Zhong 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第12期433-439,共7页
Drug-resistant bacteria present a severe threat to public health,emphasizing the importance of developing broad-spectrum antibacterial agents that are free from drug resistance.Among silver-based antibacterial agents,... Drug-resistant bacteria present a severe threat to public health,emphasizing the importance of developing broad-spectrum antibacterial agents that are free from drug resistance.Among silver-based antibacterial agents,nano-silver has been found to exhibit the most promising and comprehensive performance.The exploration of the antibacterial capacity and morphological changes of silver nanoparticles(AgNPs)could offer a starting point for the development of safe and efficient antibacterial agents.In this study,three types of nano-silver-modified polyphosphazene(PRV)nanoparticles with different morphologies were synthesized using precipitation polymerization.These nanoparticles were characterized using various techniques,including Fourier-transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and thermogravimetric analysis(TGA).The antibacterial activity of these nanoparticles against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)was assessed using minimum inhibitory concentration(MiC)/minimum bactericidal concentration(MBC)tests and inverted fluorescence microscopy.Our results revealed that the antibacterial activity of silver nanoparticles can vary significantly depending on their immobilized form.Ag@PRV Strawberry-like nanoparticles(NPs)exhibited higher antibacterial activity compared to Ag@PRV Yolk-Shell NPs and Ag@PRV Cable-like nanofibers(NFs).Notably,all three types of synthesized nanoparticles demonstrated a stronger bactericidal effect on Gram-positive bacteria than Gram-negative bacteria.Live/dead bacterial staining and scanning electron microscopy demonstrated that silver can kill bacteria by altering the permeability of their cell membranes.These findings offer valuable insights for designing and practically applying new silver-based antibacterial agents in the future. 展开更多
关键词 Nano-silver Polyphosphazene Morphology change Antibacterial activity Antibacterial mechanism
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In vitro Antibacterial Activity of Palmitoleic Acid Isolated from Filamentous Microalga Tribonema minus Against Fish Pathogen Streptococcus agalactiae 认领 引用 被引量:3
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作者 WANG Feifei GUO Yuhao +1 位作者 CAO Yan ZHANG Chengwu 《Journal of Ocean University of China》 SCIE CAS CSCD 2022年第6期1615-1621,共7页
Filamentous microalgae from genus Tribonema are promising sustainable sources of omega-7 palmitoleic acid,but their ability to accumulate this compound varies among species and depends on the initial nitrogen concentr... Filamentous microalgae from genus Tribonema are promising sustainable sources of omega-7 palmitoleic acid,but their ability to accumulate this compound varies among species and depends on the initial nitrogen concentration(INC)supply.In this study,the palmitoleic acid accumulation capacities of five Tribonema species were examined under three different INCs to select the alga species with the highest production.Results showed that a high INC was associated with increased palmitoleic acid accumulation but led to decreased biomass concentration in all tested species.In particular,T.minus grown at 18 mmol L−1INC had the highest palmitoleic acid content(20.72%of dry weight)and productivity(90.88 mg L−1d−1).The combination of alkali metal freezing precipitation(AMFP)and urea complexation successfully isolated and enriched palmitoleic acid from T.minus and obtained a purity of 80.11%and a yield of 7.39 g(100 g)−1 of algal powder.The compound was identified as(9Z)-hexadecenoic acid(C16:1ω-7).Antibacterial activity evaluation for the highly concentrated palmitoleic acid(10 mg mL−1)against Streptococcus agalactiae revealed the formation of a 12.10 mm-diameter inhibition zone and the minimum inhibitory concentration of 31.25μg mL−1,indicating that palmitoleic acid is an effective antibacterial agent.This study is the first to report that palmitoleic acid derived from T.minus can antagonize S.agalactiae,which further broadens the potential application of Tribonema biomass in green aquaculture. 展开更多
关键词 Tribonema palmitoleic acid enrichment Streptococcus agalactiae antibacterial activity
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Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain 认领 引用 被引量:3
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作者 Chen-Yu Ling Yun-Liang Tao +3 位作者 Wen-Jing Chu Hui Wang Hai-Dong Wang Yu-She Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第2期235-240,共6页
A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of ... A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12 a, 12 d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile. 展开更多
关键词 Multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one Antibacterial activity
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