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Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica 认领 引用 被引量：2
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作者 Zhamilya Abilova YUAN Jie +2 位作者 Janar Jenis TANG Chun-Ping YE Yang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2019年第10期785-791,共7页
One new dimeric(1) and two monomeric sesquiterpene lactones(5 and 13), together with 10 known compounds(2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds we... One new dimeric(1) and two monomeric sesquiterpene lactones(5 and 13), together with 10 known compounds(2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25μmol·L^-1. 展开更多
关键词 Artemisia heptapotamica Artemisiane E Artemdubolide I Ajaniaolide B Sesquiterpene lactone Anti-inflammation
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