Background:Advances in convolutional neural networks(CNNs)have continued to enhance automated brain tumor diagnosis;however,the trade-off between increasing model complexity and computational efficiency remains insuff...Background:Advances in convolutional neural networks(CNNs)have continued to enhance automated brain tumor diagnosis;however,the trade-off between increasing model complexity and computational efficiency remains insufficiently explored.Methods:This study provides a comprehensive evaluation of ten model variants from the EfficientNetV2,ConvNeXt,and InceptionNeXt families using the Brain tumor Image Segmentation and Classification(BRISC)2025 benchmark dataset.Results:By examining the efficiency frontier across these architectures,we investigate how predictive performance scales relative to computational cost.All models demonstrated robust predictive performance,with accuracies ranging from 0.972 to 0.992.The InceptionNeXt-Base model achieved the highest accuracy(0.992)and an F1-score of 0.9929.Importantly,our analysis revealed a law of diminishing returns:While computationally intensive models yielded marginal accuracy improvements,efficient architectures such as EfficientNetV2-Medium achieved comparable accuracy(0.990)with substantially lower parameter counts and latency.To validate prediction reliability,gradient-weighted class activation mapping++(Grad-CAM++)interpretability analysis was employed,confirming that the top-performing models consistently focused on anatomically relevant tumor regions rather than background artifacts.Conclusion:These findings provide practical guidance for selecting resource-efficient architectures that balance high diagnostic accuracy with the computational constraints of clinical environments.展开更多
摘要Background:Advances in convolutional neural networks(CNNs)have continued to enhance automated brain tumor diagnosis;however,the trade-off between increasing model complexity and computational efficiency remains insufficiently explored.Methods:This study provides a comprehensive evaluation of ten model variants from the EfficientNetV2,ConvNeXt,and InceptionNeXt families using the Brain tumor Image Segmentation and Classification(BRISC)2025 benchmark dataset.Results:By examining the efficiency frontier across these architectures,we investigate how predictive performance scales relative to computational cost.All models demonstrated robust predictive performance,with accuracies ranging from 0.972 to 0.992.The InceptionNeXt-Base model achieved the highest accuracy(0.992)and an F1-score of 0.9929.Importantly,our analysis revealed a law of diminishing returns:While computationally intensive models yielded marginal accuracy improvements,efficient architectures such as EfficientNetV2-Medium achieved comparable accuracy(0.990)with substantially lower parameter counts and latency.To validate prediction reliability,gradient-weighted class activation mapping++(Grad-CAM++)interpretability analysis was employed,confirming that the top-performing models consistently focused on anatomically relevant tumor regions rather than background artifacts.Conclusion:These findings provide practical guidance for selecting resource-efficient architectures that balance high diagnostic accuracy with the computational constraints of clinical environments.