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Corrigendum for Figure-related corrections in previously published articles of Bioactive Materials 认领 引用
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《Bioactive Materials》 SCIE CSCD 2026年第7期290-311,共22页
Following a routine post-publication self-review conducted by Bioactive Materials and supplementary self-inspections by the corre-sponding authors of relevant articles,various errors related to figures have been ident... Following a routine post-publication self-review conducted by Bioactive Materials and supplementary self-inspections by the corre-sponding authors of relevant articles,various errors related to figures have been identified in the published versions of the following papers from previous issues of the journal.These errors mainly include inad-vertent image duplication,incorrect use of image files,labeling/spelling inaccuracies,and technical issues in image processing or assembly. 展开更多
关键词 image processing image duplication corrigendum bioactive materials figure related corrections post publication self review image file misuse image fileslabeling spelling
本刊青年编委孙冬冬教授在Bioactive Materials刊发关于生物手性纳米药物的研究成果 认领 引用
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《安徽农业大学学报》 CAS CSCD 2026年第2期267-267,共1页
近日,安徽农业大学生命科学学院的孙冬冬教授团队联合山东第一医科大学第二附属医院的付晓艳副教授和范存东教授、中国科学院生物物理研究所范克龙研究员在Bioactive Materials(IF=20.3)上发表了题为“Chiral metal nanozyme-enabled SO... 近日,安徽农业大学生命科学学院的孙冬冬教授团队联合山东第一医科大学第二附属医院的付晓艳副教授和范存东教授、中国科学院生物物理研究所范克龙研究员在Bioactive Materials(IF=20.3)上发表了题为“Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure”的研究论文。 展开更多
关键词 SOD2激活 siRNA递送 金属纳米酶 孙冬冬 Bioactive Materials
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Bioactive materials in orthopedics:prospects and clinical translation challenges 认领 引用
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作者 Jia-Pei Yao Yu-Ting Sun +1 位作者 Cheng-Long Liu Xin-Die Zhou 《Biomedical Engineering Communications》 CAS 2025年第4期72-74,共3页
Introduction The global burden of orthopedic diseases has reached unprecedented levels,with recent epidemiological data revealing that musculoskeletal conditions affect over 1.71 billion people worldwide,representing ... Introduction The global burden of orthopedic diseases has reached unprecedented levels,with recent epidemiological data revealing that musculoskeletal conditions affect over 1.71 billion people worldwide,representing a 150%increase since 1990[1].By 2050,the number of individuals aged 60 and above requiring orthopedic interventions is projected to exceed 2.1 billion,with osteoporosis alone affecting 200 million people globally. 展开更多
关键词 clinical translation global burden epidemiological data orthopedic interventions bioactive materials osteoporosis musculoskeletal conditions orthopedics
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Bioactive Materials:A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response 认领 引用 被引量：8
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作者 Shirin Nour Nafiseh Baheiraei +4 位作者 Rana Imam Navid Rabiee Mohammad Khodaei Akram Alizadeh Seyed Mohammad Moazzeni 《Journal of Bionic Engineering》 SCIE EI CSCD 2019年第4期563-581,共19页
Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tis... Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation.However,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the implant.In this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies.Considering the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory responses.Ultimately,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface morphology.With better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed. 展开更多
关键词 implant bioactive materials cell-biomaterial interactions immune response surface engineering
Adhesive bioactive materials in ocular applications:Toward smart,regenerative,and minimally invasive therapies 认领 引用
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作者 Yifei Niu Saiqun Li +2 位作者 Fei Yu Xuan Zhao Jin Yuan 《Bioactive Materials》 SCIE CSCD 2026年第4期303-330,共28页
Ocular adhesive bioactive materials represent a paradigm shift in ophthalmic surgery and tissue repair,offering sutureless solutions with enhanced biocompatibility,reduced complications,and improved clinical outcomes.... Ocular adhesive bioactive materials represent a paradigm shift in ophthalmic surgery and tissue repair,offering sutureless solutions with enhanced biocompatibility,reduced complications,and improved clinical outcomes.Designed to function as sealants,defect fillers,and delivery vehicles for drugs or cells,these materials must meet the stringent physiological and optical demands of the ocular environment.They are typically classified by anatomical application(ocular surface vs.fundus)and material origin(natural vs.synthetic),and rely on diverse crosslinking strategies to achieve tailored mechanical and adhesive properties.Current design approaches increasingly embrace biomimetic principles—aiming to replicate the structural and functional characteristics of native ocular tissues—to improve integration and therapeutic effectiveness.Moreover,the combination of adhesive materials with regenerative therapies such as stem cells,and exosomes extends their potential from simple structural support to active tissue regeneration.This review provides a comprehensive synthesis of ocular adhesive bioactive materials,outlines major design strategies and applications,and highlights future directions toward personalized and programmable regenerative platforms capable of addressing complex ophthalmic challenges. 展开更多
关键词 Adhesive bioactive materials Ocular applications Wet tissue adhesion Corneal repair Retinal repai
Corrigendum for figure-related and funding acknowledgement corrections in previously published articles of Bioactive Materials 认领 引用
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《Bioactive Materials》 SCIE CSCD 2026年第3期I0001-I0006,共6页
Following routine post-publication checks initiated by the authors and the journal's self-review process,and subsequently verified by the editorial team,various errors related to figures and funding acknowl-edgeme... Following routine post-publication checks initiated by the authors and the journal's self-review process,and subsequently verified by the editorial team,various errors related to figures and funding acknowl-edgements have been identified in the published versions of the following papers.These errors mainly include inadvertent image duplication,image misplacement,and omission of funding sources.It is clarified that none of these corrections impact the scientific conclusions of the respective studies.Revised figures with explanatory notes and supplementary funding acknowledgements are provided herein.This corrigendum is hereby issued. 展开更多
关键词 funding acknowledgements corrigendum inadvertent image duplicationimage misplacementand bioactive materials figures
Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics 认领 引用
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作者 Xiaojun Wu Yuanming Ye +4 位作者 Mubai Sun Yongfeng Mei Bowen Ji Ming Wang Enming Song 《Cyborg and Bionic Systems》 SCIE EI CAS CSCD 2025年第1期711-738,共28页
Materials that establish functional,stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnosticherapeutic capabilities represent breakthroughs in biomedical research and clinica... Materials that establish functional,stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnosticherapeutic capabilities represent breakthroughs in biomedical research and clinical medicine.A fundamental challenge is the mechanical and chemical mismatch between tissues and implants that ultimately results in device failure for corrosion by biofluids and associated foreign body response.Of particular interest is in the development of bioactive materials at the level of chemistry and mechanics for high-performance,minimally invasive function,simultaneously with tissue-like compliance and in vivo biocompatibility.This review summarizes the most recent progress for these purposes,with an emphasis on material properties such as foreign body response,on integration schemes with biological tissues,and on their use as bioelectronic platforms.The article begins with an overview of emerging classes of material platforms for bio-integration with proven utility in live animal models,as high performance and stable interfaces with different form factors.Subsequent sections review various classes of flexible,soft tissue-like materials,ranging from self-healing hydrogel/elastomer to bio-adhesive composites and to bioactive materials.Additional discussions highlight examples of active bioelectronic systems that support electrophysiological mapping,stimulation,and drug delivery as treatments of related diseases,at spatiotemporal resolutions that span from the cellular level to organ-scale dimension.Envisioned applications involve advanced implants for brain,cardiac,and other organ systems,with capabilities of bioactive materials that offer stability for human subjects and live animal models.Results will inspire continuing advancements in functions and benign interfaces to biological systems,thus yielding therapy and diagnostics for human healthcare. 展开更多
关键词 flexible bioelectronics foreign body responseof development bioactive materials foreign body response mechanical chemical mismatch bioactive materials targeted tissues tissue compliance
Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties 认领 引用 被引量：8
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作者 Fatih Kurtuldu Nurshen Mutlu +1 位作者 Aldo R.Boccaccini Dusan Galusek 《Bioactive Materials》 SCIE CSCD 2022年第11期125-146,共22页
The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by ... The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and coatings.In this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological effects.The key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable rate.Besides,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing process.Ga is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)sites.Moreover,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications. 展开更多
关键词 Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis
Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials 认领 引用 被引量：3
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作者 Jiang Le Liu Zhongqun +13 位作者 Wang Zhaoyan Su Yijun Wang Yingjin Wei Yaojie Jiang Yanan Jia Zhanrong Ma Chunyang Gang Fangli Xu Nan Zhao Lingyun Wang Xiumei Wu Qiong Lu Xiong Sun Xiaodan 《Bioactive Materials》 SCIE CSCD 2021年第3期613-626,共14页
The fate of mesenchymal stem cells(MSCs)is regulated by biological,physical and chemical signals.Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide phy... The fate of mesenchymal stem cells(MSCs)is regulated by biological,physical and chemical signals.Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their fate.In order to design and synthesize materials that can precisely regulate the fate of MSCs,the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified,in which the detection of the fate of mesenchymal stem cells plays an important role.In the past 30 years,a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials,among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one time.In this review,the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials(BBMs)are systematically reviewed from traditional technology to high-throughput technology which is emphasized especially.Moreover,current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected.The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs,so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs. 展开更多
关键词 Bone bioactive materials High-throughput technology Transcriptomics Single cell RNA-seq Proteomics
Chitosan based bioactive materials in tissue engineering applications-A review 认领 引用 被引量：36
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作者 Md.Minhajul Islam Md.Shahruzzaman +2 位作者 Shanta Biswas Md.Nurus Sakib Taslim Ur Rashid 《Bioactive Materials》 SCIE 2020年第1期164-183,共20页
In recent years,there have been increasingly rapid advances of using bioactive materials in tissue engineering applications.Bioactive materials constitute many different structures based upon ceramic,metallic or polym... In recent years,there have been increasingly rapid advances of using bioactive materials in tissue engineering applications.Bioactive materials constitute many different structures based upon ceramic,metallic or polymeric materials,and can elicit specific tissue responses.However,most of them are relatively brittle,stiff,and difficult to form into complex shapes.Hence,there has been a growing demand for preparing materials with tailored physical,biological,and mechanical properties,as well as predictable degradation behavior.Chitosan-based materials have been shown to be ideal bioactive materials due to their outstanding properties such as formability into different structures,and fabricability with a wide range of bioactive materials,in addition to their biocompatibility and biodegradability.This review highlights scientific findings concerning the use of innovative chitosan-based bioactive materials in the fields of tissue engineering,with an outlook into their future applications.It also covers latest developments in terms of constituents,fabrication technologies,structural,and bioactive properties of these materials that may represent an effective solution for tissue engineering materials,making them a realistic clinical alternative in the near future. 展开更多
关键词 Chitosan Bioactive material Scaffold Tissue engineering
Bioactive materials for in vivo sweat gland regeneration 认领 引用 被引量：2
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作者 Xinling Yang Mingchen Xiong +1 位作者 Xiaobing Fu Xiaoyan Sun 《Bioactive Materials》 SCIE CSCD 2024年第1期247-271,共25页
Loss of sweat glands(SwGs)commonly associated with extensive skin defects is a leading cause of hyperthermia and heat stroke.In vivo tissue engineering possesses the potential to take use of the body natural ability t... Loss of sweat glands(SwGs)commonly associated with extensive skin defects is a leading cause of hyperthermia and heat stroke.In vivo tissue engineering possesses the potential to take use of the body natural ability to regenerate SwGs,making it more conducive to clinical translation.Despite recent advances in regenerative medicine,reconstructing SwG tissue with the same structure and function as native tissue remains challenging.Elucidating the SwG generation mechanism and developing biomaterials for in vivo tissue engineering is essential for understanding and developing in vivo SwG regenerative strategies.Here,we outline the cell biology associated with functional wound healing and the characteristics of bioactive materials.We critically summarize the recent progress in bioactive material-based cell modulation approaches for in vivo SwG regeneration,including the recruitment of endogenous cells to the skin lesion for SwG regeneration and in vivo cellular reprogramming for SwG regeneration.We discussed the re-establishment of microenvironment via bioactive material-mediated regulators.Besides,we offer promising perspectives for directing in situ SwG regeneration via bioactive material-based cell-free strategy,which is a simple and effective approach to regenerate SwG tissue with both fidelity of structure and function.Finally,we discuss the opportunities and challenges of in vivo SwG regeneration in detail.The molecular mechanisms and cell fate modulation of in vivo SwG regeneration will provide further insights into the regeneration of patient-specific SwGs and the development of potential intervention strategies for gland-derived diseases. 展开更多
关键词 Bioactive material Regeneration Reprogramming Sweat gland Microenvironment
Development of bioactive materials for glioblastoma therapy 认领 引用 被引量：2
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作者 Jun Yang Yan Li +1 位作者 Tianlu Zhang Xin Zhang 《Bioactive Materials》 2016年第1期29-38,共10页
Glioblastoma is the most common and deadly human brain cancers.Unique barriers hinder the drug delivering pathway due to the individual position of glioblastoma,including blood-brain barrier and blood-brain tumor barr... Glioblastoma is the most common and deadly human brain cancers.Unique barriers hinder the drug delivering pathway due to the individual position of glioblastoma,including blood-brain barrier and blood-brain tumor barrier.Numerous bioactive materials have been exploited and applied as the transvascular delivery carriers of therapeutic drugs.They promote site-specific accumulation and long term release of the encapsulated drugs at the tumor sites and reduce side effects with systemic delivery.And the delivery systems exhibit a certain extent of anti-glioblastoma effect and extend the median survival time.However,few of them step into the clinical trials.In this review,we will investigate the recent studies of bioactive materials for glioblastoma chemotherapy,including the inorganic materials,lipids and polymers.These bioactive materials construct diverse delivery vehicles to trigger tumor sites in brain intravenously.Herein,we exploit their functionality in drug delivery and discuss the deficiency for the featured tumors,to provide guidance for establishing optimized therapeutic drug formulation for anti-glioblastoma therapy and pave the way for clinical application. 展开更多
关键词 Glioblastoma Bioactive material Blood-brain barrier Blood-brain tumor barrier Chemotherapy
Aims and Scope 认领 引用
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《Bioactive Materials》 SCIE CSCD 2026年第8期F0002-F0002,共1页
Bioactive Materials is an international,peer-reviewed research publication covering all aspects of bioactive materials.The journal welcomes the submission of research papers,reviews and rapid communications that are c... Bioactive Materials is an international,peer-reviewed research publication covering all aspects of bioactive materials.The journal welcomes the submission of research papers,reviews and rapid communications that are concerned with the science and engineering of next-generation biomaterials that come into contact with cells,tissues or organs across all living species.Bioactive materials will feature adaptiveness to the biological environment,being designed to stimulate and/or direct appropriate cellular and tissue responses,or control interactions with microbiological species. 展开更多
关键词 biomaterials cellular ti cellular responses rapid communications bioactive materials science bioactive materialsthe engineering
Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration 认领 引用 被引量：5
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作者 Shihong Zhu Xiaoyin Liu +7 位作者 Xiyue Lu Qiang Liao Huiyang Luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu Jing Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第10期2157-2174,共18页
Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. ... Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential. 展开更多
关键词 bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury
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Preparation of Biologically Active Materials by Biomimetic Process 认领 引用
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作者 樊东辉 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2002年第1期19-22,共4页
In order to form the apatite nuclei on a surface of the substrate, the substrate was placed on or in CaO, SiO2-based glass particles which were soaked in a simulated body fluid with ion concentrations nearly e-qual to... In order to form the apatite nuclei on a surface of the substrate, the substrate was placed on or in CaO, SiO2-based glass particles which were soaked in a simulated body fluid with ion concentrations nearly e-qual to those of human blood plasma, and to make the apatite nuclei grow on the substrate in situ, the substrate, was soaked in another solution highly supersaturated with respect to the apatite. The induction period for the apatite nucleation varied from 0 to 4 days depending on the kind of the substrate. The thickness of the apatite layer increases linearly with increasing soaking time in the second solution. The rate of growth of the apatite layer increases with increasing degree of the supersaturation and temperature of the second solution, reaching 7um/d in a solution with ion concentrations which is as 1.5 times as those of the simulated body fluid at 60℃. The adhesive strength of the apatite layer to the substrate varies depending on the kind and roughness of the substrate. Polyethyleneterephthalate and polyethersulfone plates abraded with No. 400 diamond paste show adhesive strengths of as high as 4 MPa. This type of composite of the bone-like apatite with metals, ceramics and organic polymers might be useful not only as highly biaactive hard tissue-repairing materials with analogous mechanical properties to those of the hard tissues , but also as highly biocompatible soft tissue-repairing materials with ductility. 展开更多
关键词 bioactive materials biomimetic process preparation apatite nudes
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Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury 认领 引用 被引量：8
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作者 Wanlin Xu Yifan Wu +3 位作者 Hao Lu Yun Zhu Jinhai Ye Wenjun Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第9期2064-2071,共8页
Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration ... Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration arriving at the injury site results in unsatisfactory outcomes.Therefore,there is an urgent need for a treatment method that can increase the effective drug concentration in the injured area.In this study,we first fabricated a gelatin modified by methacrylic anhydride hydrogel and loaded it with vascular endothelial growth factor that allowed the controlled release of the neurotrophic factor.This modified gelatin exhibited good physical and chemical properties,biocompatibility and supported the adhesion and proliferation of RSC96 cells and human umbilical vein endothelial cells.When injected into the epineurium of crushed nerves,the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration,functional recovery and vascularization.The results showed that the modified gelatin gave sustained delivery of vascular endothelial growth factors and accelerated the repair of crushed peripheral nerves. 展开更多
关键词 bioactive material controlled release crush injury hydrogel muscle function nerve regeneration peripheral nerve sciatic function index vascular endothelial growth factor vascularization
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Magnesium alloy implant GZ31K with enhanced corrosion resistance promotes fracture healing in vitro and in vivo systems 认领 引用
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作者 Yalikun Yusufu Yunyang Zhang +5 位作者 Xinyun Liu Jiahao Jiang Zhiqiang Shao Minghui Sun Xiaobo Zhang Qing Jiang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2025年第10期5132-5144,共13页
Magnesium and its alloys have garnered significant attention as promising materials for bone tissue engineering,owing to their bone-like density and elastic modulus,favorable mechanical properties,biodegradability,bio... Magnesium and its alloys have garnered significant attention as promising materials for bone tissue engineering,owing to their bone-like density and elastic modulus,favorable mechanical properties,biodegradability,biocompatibility,and diverse biological activities.However,rapid degradation,subcutaneous gas formation from H2release,and osteolysis caused by elevated Mg concentrations have limited its widespread clinical application.In this study,Mg-3.0Gd-1Zn-0.4Zr(GZ31K)alloy with desirable uniform degradation and stress corrosion resistance under extruded and drawn condition was used as internal fixation implants for fracture healing,while the commercially available WE43 alloy was used as control.Results revealed that GZ31K alloy exhibited refined grain structure,nanoscale distributed stacking faults and superior corrosion resistance compared to WE43 alloy.The corrosion rate of the extruded GZ31K and WE43 alloys are 0.25 mm/year and 0.35 mm/year,meeting the corrosion tolerance threshold for orthopedic implants(<0.5 mm/year).In vitro study demonstrated that GZ31K alloy exhibited pronounced biocompatibilities and osteogenic bioactivities towards rat bone marrow mesenchymal stem cells(rBMSCs)compared with WE43 alloy,as evidenced by the enhanced ALP activity level,mineralized nodule formation and expression of osteogenicrelated marker genes.In vivo results confirmed that GZ31K alloy retained its above 87.1%structural integrity for up to 8 weeks postimplantation and exhibited better corrosion resistance compared to the WE43 alloy(80.9%).Besides,the Sprague-Dawley rats administrated with GZ31K alloy exhibited greater bone volume,trabecular thickness,satisfactory load-bearing performance and surface degradation behavior at 8 weeks post-fracture healing compared to the Kirschner wire and the WE43 alloy.Taken together,these findings highlighted that GZ31K alloy with slower degradation rate,enhanced structural stability,exceptional biocompatibilities and osteogenic potential might provide sustained structural integrity and mechanical support throughout the fracture healing process,positioning it as a strong candidate for next-generation orthopedic implants. 展开更多
关键词 Biodegradable magnesium alloy Osteoporotic fracture healing Orthopedic implant Bioactive material Degradation
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A core scientific problem in the treatment of central nervous system diseases:newborn neurons 认领 引用 被引量：8
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作者 Peng Hao Zhaoyang Yang +1 位作者 Kwok-Fai So Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2588-2601,共14页
It has long been asserted that failure to recover from central nervous system diseases is due to the system's intricate structure and the regenerative incapacity of adult neurons.Yet over recent decades,numerous s... It has long been asserted that failure to recover from central nervous system diseases is due to the system's intricate structure and the regenerative incapacity of adult neurons.Yet over recent decades,numerous studies have established that endogenous neurogenesis occurs in the adult central nervous system,including humans'.This has challenged the long-held scientific consensus that the number of adult neurons remains constant,and that new central nervous system neurons cannot be created or renewed.Herein,we present a comprehensive overview of the alterations and regulatory mechanisms of endogenous neurogenesis following central nervous system injury,and describe novel treatment strategies that to rget endogenous neurogenesis and newborn neurons in the treatment of central nervous system injury.Central nervous system injury frequently results in alterations of endogenous neurogenesis,encompassing the activation,proliferation,ectopic migration,diffe rentiation,and functional integration of endogenous neural stem cells.Because of the unfavorable local microenvironment,most activated neural stem cells diffe rentiate into glial cells rather than neurons.Consequently,the injury-induced endogenous neurogenesis response is inadequate for repairing impaired neural function.Scientists have attempted to enhance endogenous neurogenesis using various strategies,including using neurotrophic factors,bioactive materials,and cell reprogramming techniques.Used alone or in combination,these therapeutic strategies can promote targeted migration of neural stem cells to an injured area,ensure their survival and diffe rentiation into mature functional neurons,and facilitate their integration into the neural circuit.Thus can integration re plenish lost neurons after central nervous system injury,by improving the local microenvironment.By regulating each phase of endogenous neurogenesis,endogenous neural stem cells can be harnessed to promote effective regeneration of newborn neurons.This offers a novel approach for treating central nervous system injury. 展开更多
关键词 bioactive materials brain trauma endogenous neurogenesis hippocampal dentate gyrus neural stem cells neurotrophic factors newborn neurons spinal cord injury stroke subventricular zone
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Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering 认领 引用 被引量：5
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作者 Min Wang Peng Xu Bo Lei 《Bioactive Materials》 SCIE CSCD 2023年第1期511-537,共27页
Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine.Citrate-based polymers are the few bioactive polymer biomaterials used in biomedic... Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine.Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis,controllable structure,biocompatibility,biomimetic viscoelastic mechanical behavior,and functional groups available for modification.In recent years,various multifunctional designs and biomedical applications,including cardiovascular,orthopedic,muscle tissue,skin tissue,nerve and spinal cord,bioimaging,and drug or gene delivery based on citrate-based polymers,have been extensively studied,and many of them have good clinical application potential.In this review,we summarize recent progress in the multifunctional design and biomedical applications of citrate-based polymers.We also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications. 展开更多
关键词 Bioactive materials Bioactive polymers Citrate-based biomaterials Multifunctional modification Tissue engineering
Egg components as bioactive and structural inputs for cultured meat 认领 引用
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作者 Da Young Lee Colin Venter +7 位作者 Ermie Jr.Mariano Ji Won Park Seok Namkung So Young Choi Ye Won Shin Chae Hyeon Bok Woo Jin Lee Sun Jin Hur 《Food Bioscience》 SCIE 2025年第12期400-409,共10页
Cultured meat offers a promising alternative to conventional meat,but its commercial viability depends on replacing costly components,such as media supplements and scaffolds.Eggs are nutrient-rich products with establ... Cultured meat offers a promising alternative to conventional meat,but its commercial viability depends on replacing costly components,such as media supplements and scaffolds.Eggs are nutrient-rich products with established roles in both food and biotechnology,yet they remain an underexplored source of bioactive sup-plements and biomaterials for cultured meat production.Because unfertilized eggs can be collected without harming animals,they represent an ethical and sustainable source of animal-derived bioactive compounds that can also be recovered as agricultural waste by-products.This review examines the potential of individual egg components(egg white,yolk,and eggshell membrane)to support muscle and fat cell proliferation,differenti-ation,and tissue structuring.Research findings suggest that yolk-derived proteins and lipids enhance adipocyte differentiation and lipid accumulation,while egg white proteins,such as ovalbumin and ovomucoid,especially in hydrolyzed form,promote both myogenesis and adipogenesis.The eggshell membrane,rich in extracellular matrix components such as collagen and glycoproteins,may serve as a food-safe,natural scaffold to support cell adhesion and organization.However,eggs are inherently heterogeneous and contain components such as vitamin-binding proteins that may limit cell growth,and allergenic proteins that pose challenges for downstream food safety regulation.As a result,effective application of egg-derived materials in cultured meat will likely require some degree of processing and standardization. 展开更多
关键词 Egg ingredients Bioactive materials Cultured meat Scaffolds
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