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Investigation of the Holding Capability of the Dielectrophoretic Gate and Sorter System for Biodetection 认领 引用
1
作者 Hongjun Song Ziliang Cai Dawn J. Bennett 《Open Journal of Applied Biosensor》 2013年第2期65-75,共11页
The dielectrophoretic gate and sorter system has been widely applied for preconcentrating and sorting of bioparticles for biodetection. In such systems, the dielectrophoretic force is generated by applying an AC elect... The dielectrophoretic gate and sorter system has been widely applied for preconcentrating and sorting of bioparticles for biodetection. In such systems, the dielectrophoretic force is generated by applying an AC electric field on the three dimensional electrode systems (containing a pair of electrodes on the top and bottom of the channel). Particles are held and sorted by balancing the DEP force with the hydrodynamic drag force. The holding capability is very important for such systems because it determines the preconcentration and sorting efficiency. In this paper, we investigate the holding capability of a simple dielectrophoretic gate system. Initially, a three dimensional numerical scheme was introduced to estimate the holding capability and was further validated by comparing with experimental results. Second, we systematically investigated the effects of the phase difference between the top and bottom electrodes;the height and width of the channel, and the relative position and size of top and bottom electrodes. The results demonstrated that the maximum holding capability is reached when the phase difference between the top and bottom electrodes is around 180o. The results also show that the holding capability varied with the size and relative position of electrodes on the top and bottom, and the maximum holding capability is obtained when the top and bottom electrodes had the same size and the centers of both electrodes overlapped. 展开更多
关键词 Biodetection Dielectrophoresis Microfludic System Particle Separation
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Noble metal nanozymes for biodetection:Current state-of-the-art and accelerated discovery with artificial intelligence 认领 引用
2
作者 Yu WANG Shengqi WU +7 位作者 Hengyu HAO Shanhu LIU Yue CAO Yang ZHOU Yangxing LUO Shichao DING Xiaoli CAI Wenlei ZHU 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2026年第7期74-95,共22页
Nanozymes have attracted considerable attention for their capability to replicate the catalytic functions of natural enzymes while addressing several intrinsic limitations.Within this category,noble metal nanozymes ar... Nanozymes have attracted considerable attention for their capability to replicate the catalytic functions of natural enzymes while addressing several intrinsic limitations.Within this category,noble metal nanozymes are distinguished by unique electronic structures,broad enzyme-mimic activities,and excellent stability,conferring great potential for biosensing and positioning them as a highly active area of biomedical research.This review outlines the classification of enzyme-like activities of noble metal nanozymes and examines their applications in biodetection,including noble metal nanocrystals,noble metal single-atom nanozymes,and artificial intelligence-assisted noble metal nanozymes.The recent advances in artificial intelligence for nanozyme research are also summarized.Moreover,current challenges and prospective research directions are discussed in relation to mechanistic understanding,material optimization,and the exploration of broader application scenarios.Continued research will be essential to unlock the full potential of noble metal nanozymes and advance their translation into reliable clinical and point-of-care diagnostic platforms. 展开更多
关键词 noble metal nanozymes enzyme-like activity single-atom nanozymes biodetection artificial intelligence
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Superwettable interface towards biodetection in confined space 认领 引用 被引量：1
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作者 Zexu Pang Zhikang Cao +5 位作者 Wanlu Li Wenxia Xu Yingying Zhang Qitao Zhou Jing Pan Fan Xia 《Nano Research》 SCIE EI CSCD 2024年第2期602-617,共16页
The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related diseases.However,many current detections employ ex-situ detection method and non-confined co... The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related diseases.However,many current detections employ ex-situ detection method and non-confined condition,thus have many problems,which may eventually lead to inaccurate detection results.Compared to detection in non-confined space,detection in confined space can better reflect the real in-vivo situation.Therefore,the construction of detection for target molecules in confined space has great significance for both theoretical research and practical application.To realize the detection of target molecules in confined space,the probes should accurately enter the confined space where the target molecules reside and interact with the interface.Thus,how to explore and utilize the properties of the interface(for example,bioinspired superwettability)has always been a hot and difficult topic in this field.Herein,the recent advances and our efforts in recent 10 years on detection of bio-target molecules in confined space with superwettable interface have been introduced from the perspective of the detection methods.The suitable and most widely employed detection methods for target molecules in confined spaces are introduced firstly.Then,recent progresses for related detections based on visual,optical,and electrochemical detection methods are presented successively.Finally,the perspective for detection in confined space is discussed for the future development of biochemical detection. 展开更多
关键词 biodetection superwettability confined space interface
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Versatile metal graphitic nanocapsules for SERS bioanalysis 认领 引用 被引量：2
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作者 Shengkai Li Jiamei Xu +3 位作者 Shen Wang Xin Xia Long Chen Zhuo Chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第9期1581-1592,共12页
The novel graphitic nanomaterial of metal graphitic nanocapsules(MGNs) with superior stability, unique optical properties and biocompatibility possess great potential in biomedical and bioanalytical applications. The ... The novel graphitic nanomaterial of metal graphitic nanocapsules(MGNs) with superior stability, unique optical properties and biocompatibility possess great potential in biomedical and bioanalytical applications. The graphitic shell can quench the background fluorescence interference from external environments via a fluorescence resonance energy transfer(FRET) process and even avoid unnecessary reactions catalyzed by inner metal core. The graphitic shell with several characteristic Raman bands itself can act as Raman signal probe or internal standard(IS), especially the 2D-band within the cellular Raman-silent region helps to reduce the interference signals from external conditions. The present context attempts to give a comprehensive overview about the preparation and unique properties of MGNs as well as their applications in SERS biodetection and bioimaging. 展开更多
关键词 Versatile Metal graphitic nanocapsules SERS Biodetection Bioimaging
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Dioxin impacts on lipid metabolism of soil microbes:towards effective detection and bioassessment strategies 认领 引用 被引量：1
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作者 Sabrin Mahfouz Ghaytha Mansour +1 位作者 Denis J.Murphy Abdulsamie Hanano 《Bioresources and Bioprocessing》 SCIE EI 2020年第1期76-92,共17页
Dioxins are the most toxic known environmental pollutants and are mainly formed by human activities.Due to their structural stability,dioxins persist for extended periods and can be transported over long distances fro... Dioxins are the most toxic known environmental pollutants and are mainly formed by human activities.Due to their structural stability,dioxins persist for extended periods and can be transported over long distances from their emission sources.Thus,dioxins can be accumulated to considerable levels in both human and animal food chains.Along with sediments,soils are considered the most important reservoirs of dioxins.Soil microorganisms are therefore highly exposed to dioxins,leading to a range of biological responses that can impact the diversity,genetics and functional of such microbial communities.Dioxins are very hydrophobic with a high affinity to lipidic macromolecules in exposed organisms,including microbes.This review summarizes the genetic,molecular and biochemical impacts of dioxins on the lipid metabolism of soil microbial communities and especially examines modifications in the composition and architecture of cell membranes.This will provide a useful scientific benchmark for future attempts at soil ecological risk assessment,as well as in identifying potential dioxin-specific-responsive lipid biomarkers.Finally,potential uses of lipid-sequestering microorganisms as a part of biotechnological approaches to the bio-management of environmental contamination with dioxins are discussed. 展开更多
关键词 Dioxins Soil microbes Lipid metabolism Biodetection Bioremediation
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Biological Switch of Positive-to-Negative Photoconductivity in Graphene Photoelectrochemical Transistor for High-Resolution Detection at Low Concentrations 认领 引用
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作者 Yue Jiang Cheng-Shuang Wang +6 位作者 Cheng Yuan Yan Wang Yuan-Cheng Zhu Fen-Ying Kong Hui-Min Jia Wei Wang Wei-Wei Zhao 《Journal of Analysis and Testing》 EI CSCD 2026年第2期654-662,共9页
Recently,the positive-to-negative photoconductivity(PPC-to-NPC)switch has been increasingly explored in optoelectronic devices for innovative applications.Light-bio-matter interplay has been demonstrated as a versatil... Recently,the positive-to-negative photoconductivity(PPC-to-NPC)switch has been increasingly explored in optoelectronic devices for innovative applications.Light-bio-matter interplay has been demonstrated as a versatile way to regulate the advanced photoelectrochemical transistor characteristics.Here,it is reported that a graphene photoelectrochemical transistor(GPECT)gated by CdS nanorods features a unique biological PPC-to-NPC switch,which enables high-resolution detection at low concentrations.In a process involving biocatalytic precipitation,the suppressed photoinduced positive photovoltage drives cations towards the channel.This modifies the physics of the graphene transistor,inducing a negative shift in the Dirac point and enabling the PPC-to-NPC switch.Interestingly,such a device demonstrates a negative correlation related to biorecognition in GPECT detection,which could amplify the channel current and enhance signal resolution at low concentrations.It is expected to stimulate further exploration on advanced GPECT with unknown possibilities. 展开更多
关键词 Graphene Photoelectrochemical transistor Negative photoconductivity Biodetection
Handheld high-throughput plasmonic biosensor using computational on-chip imaging 认领 引用 被引量：13
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作者 Arif E Cetin Ahmet F Coskun +4 位作者 Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug 《Light: Science & Applications》 SCIE EI 2014年第1期388-397,共10页
We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular intera... We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. 展开更多
关键词 computational imaging high-throughput biodetection lens-free imaging on-chip sensing plasmonics point of care diagnostics telemedicine
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Mn2+-activated calcium fluoride nanoprobes for time-resolved photoluminescence biosensing 认领 引用 被引量：3
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作者 Jiaojiao Wei Wei Zheng +7 位作者 Xiaoying Shang Renfu Li Ping Huang Yan Liu Zhongliang Gong Shanyong Zhou Zhuo Chen Xueyuan Chen 《Science China Materials》 SCIE EI CAS CSCD 2019年第1期130-137,共8页
Time-resolved (TR)photoluminescence (PL) technique has shown great promise in ultrasensitive biodetection and high-resolution bioimaging.Hitherto,almost all the TRPL bioprobes are based on the parity-forbidden f→f tr... Time-resolved (TR)photoluminescence (PL) technique has shown great promise in ultrasensitive biodetection and high-resolution bioimaging.Hitherto,almost all the TRPL bioprobes are based on the parity-forbidden f→f transition of lanthanide ions.Herein,we report TRPL biosensing by taking advantage of the d→d transition of transition metal (TM)Mn^2+ ion.We demonstrate that the Forster resonance energy transfer (FRET)signal can be distinguished from that of radiative reabsorption process through measuring the PL lifetime of Mn^2+,thus establishing a reliable method for Mn^2+ in homogeneous TR-FRET biodetection.We also demonstrate the biotin receptor-targeted cancer cell imaging by utilizing biotinylated CaF2:Ce,Mn nanoprobes.Furthermore,we show in a proof-of-concept experiment the appli- cation of the long-lived PL of Mn^2+ for TRPL bioimaging through the burst shot with a cell phone.These findings provide a general approach for exploiting the long-lived PL of TM ions for TRPL biosensing,thereby opening up a new avenue for the exploration of novel and versatile applications of TM ions. 展开更多
关键词 manganese time-resolved photoluminescence energy transfer biodetection bioimaging
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Nanocatalytic Medicine of Iron-Based Nanocatalysts 认领 引用 被引量：2
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作者 Peilei Liu Minfeng Huo Jianlin Shi 《CCS Chemistry》 CSCD 2021年第2期2445-2463,共19页
Iron can be found in all mammalian cells and is of critical significance to diverse cellular activities within human bodies.Widespread applications and the underlying chemical and biological fundamental explorations o... Iron can be found in all mammalian cells and is of critical significance to diverse cellular activities within human bodies.Widespread applications and the underlying chemical and biological fundamental explorations of iron-based nanomaterials,especially on the biomedical frontiers,have attracted growing interests most recently in the community.In this review,we focus on the catalytic performance of iron-based nanomaterials(termed as nanocatalysts,abbreviated as NCs)and their nanocatalytic biomedical applications in Fenton nanocatalytic therapeutics,nanocatalytic oxygenation-enabled therapeutics,and nanocatalytic peroxidation-enabled biodetections.Fabrication methodologies of the iron-based NCs are also summarized along with their applications.Representative therapeutic performance against malignant tumors,Alzheimer’s disease(and other pathological abnormalities),and nanocatalyticbased biodetection are discussed.Finally,future development prospects of the iron-based NCs are surveyed,aiming to deliver a brighter future for iron-based NCs in nanocatalytic medicine. 展开更多
关键词 iron-based nanocatalysts Fenton catalysis,antioxidation peroxidase-like biodetections
Developing sensor materials for screening intestinal diseases 认领 引用
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作者 Cheng Zhao Xiaoxuan Zhang +1 位作者 Guopu Chen Luoran Shang 《Materials Futures》 2022年第2期64-88,共25页
Intestinal diseases that have high mortality and morbidity rates and bring huge encumbrance to the public medical system and economy worldwide,have always been the focus of clinicians and scientific researchers.Early ... Intestinal diseases that have high mortality and morbidity rates and bring huge encumbrance to the public medical system and economy worldwide,have always been the focus of clinicians and scientific researchers.Early diagnosis and intervention are valuable in the progression of many intestinal diseases.Fortunately,the emergence of sensor materials can effectively assist clinical early diagnosis and health monitoring.By accurately locating the lesion and sensitively analyzing the level of disease markers,these sensor materials can help to precisely diagnose the stage and state of lesions,thereby avoiding delayed treatment.In this review,we provide comprehensive and in-depth knowledge of diagnosing and monitoring intestinal diseases with the assistance of sensor materials,particularly emphasizing their design and application in bioimaging and biodetection.This review is dedicated to conveying practical applications of sensor materials in the intestine,critical analysis of their mechanisms and applications and discussion of their future roles in medicine.We believe that this review will promote multidisciplinary communication between material science,medicine and relevant engineering fields,thus improving the clinical translation of sensor materials. 展开更多
关键词 sensors intestine disease bioimaging biodetection
Research progress of nanoparticles as enzyme mimetics 认领 引用 被引量：6
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作者 HU XiaoNa LIU JianBo +8 位作者 HOU Shuai WEN Tao LIU WenQi ZHANG Ke HE WeiWei JI YingLu REN HongXuan WANG Qi WU XiaoChun 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第10期1749-1756,共8页
Natural enzymes as biological catalysts possess remarkable advantages,especially their highly efficient and selective catalysis under mild conditions.However,most natural enzymes are proteins,thus exhibiting an inhere... Natural enzymes as biological catalysts possess remarkable advantages,especially their highly efficient and selective catalysis under mild conditions.However,most natural enzymes are proteins,thus exhibiting an inherent low durability to harsh reaction conditions.Artificial enzyme mimetics have been pursued extensively to avoid this drawback.Quite recently,some inorganic nanoparticles(NPs) have been found to exhibit unique enzyme mimetics.In addition,their much higher stability overcomes the inherent disadvantage of natural enzymes.Furthermore,easy mass-production and low cost endow them more benefits.As a new member of artificial enzyme mimetics,they have received intense attention.In this review article,major progress in this field is summarized and future perspectives are highlighted. 展开更多
关键词 artificial enzyme mimetics Fe_3O_4 nanoparticles CeO_2 nanoparticles Pt nanoparticles biodetection
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Unravelling phase and morphology evolution of NaYbF4upconversion nanoparticles via modulating reaction parameters 认领 引用 被引量：2
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作者 Xuechun Pan Jilou Ren +3 位作者 Jianfeng Zeng Mingyue Liu Zhenlan Fang Qiang Ju 《Inorganic Chemistry Frontiers》 SCIE EI 2022年第16期4081-4090,共10页
The applications of upconversion nanoparticles in biodetection,bioimaging,and lighting have greatly fuelled a growing demand for enhancing their brightness.The brightness of upconversion nanoparticles is fundamentally... The applications of upconversion nanoparticles in biodetection,bioimaging,and lighting have greatly fuelled a growing demand for enhancing their brightness.The brightness of upconversion nanoparticles is fundamentally limited by the low doping concentration of either activator or sensitizer ions,in spite of the progress of rational controlling nanoparticles to improve performance.Although NaYbF4nano-particles possessing the largest amount of sensitizers(Yb3+)have been proposed as a promising alterna-tive host to achieve bright upconversion luminescence,systemic explorations in synthesizing NaYbF4nanoparticles have scarcely been performed.In this work,we report the systematic synthesis and fine control of monodisperse NaYbF4nanoparticles through a canonical high-temperature co-precipitation method.The phase and morphology of NaYbF4nanoparticles can be rationally tuned,through modulat-ing the amount of NH4 F,amount of NaOH,temperature,and time,respectively.The heating rate has also been found to exert an effect on the phase and morphology evolution of NaYbF4nanoparticles for the first time.The size of NaYbF4nanoparticles can be modulated from hundreds to several nanometers,in addition to the variation of their phase and morphology.The optical properties of NaYbF4:Er upconver-sion nanoparticles obtained under different reaction parameters have been investigated,and moreover,their potential applications in imaging deep tissue and photodynamic therapy have been explored.Unravelling the phase and morphology evolution of NaYbF4nanoparticles is expected to hold great potential for boosting the brightness of upconversion nanoparticles. 展开更多
关键词 morphology evolution phase evolution biodetection enhancing their brightnessthe naybf nanoparticles rational controlling nanoparticles upconversion nanoparticles bioimaging
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