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Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy 认领 引用
1
作者 Xueyan Zhen Linhao Li +4 位作者 Lanlan Jia Aihong Zhu Yixuan Yang Sicen Wang Xiaoyu Xie 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第4期116-121,共6页
Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficie... Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy.Herein, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy. 展开更多
关键词 Aptamer Self-protective Biointerface Targeted drug delivery Synergistic chemotherapy
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Biointerface interaction regulation based on organic semiconducting polymers 认领 引用
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作者 Xiaoning Liu Boying Li +5 位作者 Liang Qiu Dong Gao Ran Zhang Junjie Qi Honggui Lv Chengfen Xing 《Fundamental Research》 CSCD 2026年第1期560-574,共15页
In complex biological systems,physical factors such as light and thermal energy affect normal physiological pro-cesses.When exposed to light stimulation,organic semiconducting polymers(OSPs)alter their physical/chemic... In complex biological systems,physical factors such as light and thermal energy affect normal physiological pro-cesses.When exposed to light stimulation,organic semiconducting polymers(OSPs)alter their physical/chemical properties through unique energy conversion capabilities,thereby regulating interfacial interactions with cells or microorganisms.In cellular interfacial interactions,ion channels act as key response elements to exogenous phys-ical stimuli,precisely regulating physiological processes by mediating ion transmembrane transport;in microbial interfacial interactions,exogenous physical factors also significantly impact bacterial functional expression,drug resistance formation,and other aspects.In recent years,leveraging exogenous physical factors to achieve non-invasive or precise regulation of cellular/bacterial signaling pathways,molecular interactions,and metabolic processes has emerged as a frontier in physical biomedicine.Here,the latest research achievements of OSPs are summarized:under the action of external physical factors,they can regulate disease-related signaling pathways by modulating interfacial interactions with cells.Meanwhile,their regulation of microbial interfacial interactions can further affect the interactions between pathogens. 展开更多
关键词 Organic semiconducting polymers Photo stimulus responsive Biointerface interaction regulation Ion channels Disease-related signaling pathway Pathogen interactions Bacterial drug resistance Physically biological regulation
Metal-Organic Framework Membranes as Biointerfaces for Compartmentalized Soft-Matter Protocells 认领 引用
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作者 Yuwen Li Yongming Xia Xiangmin Tong 《Aggregate》 EI CAS CSCD 2026年第3期404-407,共4页
Metal-organic frameworks(MOFs)have long been highly regarded for their crystalline order,structural modularity,and precisely defined porosity.Metal nodes and organic linkers form ordered lattices with defined pores,en... Metal-organic frameworks(MOFs)have long been highly regarded for their crystalline order,structural modularity,and precisely defined porosity.Metal nodes and organic linkers form ordered lattices with defined pores,enabling predictable adsorp-tion and transport processes.Traditionally,research on MOFs has primarily focused on established fields such as molecular adsorption and heterogeneous catalysis[1,2] 展开更多
关键词 adsorption molecular adsorption biointerfaces compartmentalized soft matter protocells heterogeneous catalysis organic linkers ordered lattices metal organic frameworks
Construction of microenvironmental biointerfaces 认领 引用
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作者 Kaiyong Cai Yan Hu Zhong Luo 《医用生物力学》 EI CAS 2010年第S1期52-53,共2页
Biomaterial acts as artificial extracellular matrix for providing a provisional three-dimensional(3D)microenvironments to interact biophysically and/or biochemically with cells to regulate cell behaviors,such as cell ... Biomaterial acts as artificial extracellular matrix for providing a provisional three-dimensional(3D)microenvironments to interact biophysically and/or biochemically with cells to regulate cell behaviors,such as cell adhesion,migration. 展开更多
关键词 cell gene Construction of microenvironmental biointerfaces
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Soft electronic fibres weave a new path to multifunctional biointerfaces 认领 引用
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作者 Jing Zhao Chunfeng Wang 《Science Bulletin》 SCIE EI CAS CSCD 2026年第2期223-225,共3页
The human body operates through an intricate network of electrical,mechanical,and chemical signals.These signals coordinate the communication among organs,tissues,and cells,sustaining vital functions and adapting to e... The human body operates through an intricate network of electrical,mechanical,and chemical signals.These signals coordinate the communication among organs,tissues,and cells,sustaining vital functions and adapting to environmental stimuli.Establishing direct communication between electronic devices and this living network is a central goal in modern bioengineering,with the potential to revolutionize fields such as neuroscience,cardiology,and gastroenterology[1-3]. 展开更多
关键词 direct communication biointerfaces cardiology neuroscience bioengineering living network electronic fibres electronic devices
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Imperceptible biointerfaces enabled by hydrogel-elastomer-based conductive nanomembranes 认领 引用 被引量：1
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作者 Yinglin Zhi Yuda Chen +1 位作者 Jingjia Li Yanhao Yu 《National Science Open》 CSCD 2026年第2期14-16,共3页
Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integ... Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integration between electronic systems and biological tissues,enabling the long-term stable monitoring of biosignals and precise diagnosis and therapy within closed-loop configurations.The past decade has seen transformative growth in this field,yielding numerous novel conformal integration strategies.These include seminal developments such as ultra-thin epidermal electronics[1,2],conformal bioelectronics fabrication or encapsulation using viscoplastic effect[3,4],and a“drop-printing”strategy for damage-free,conformal wrapping of bioelectronic interfaces through dynamic stress release[5].However,a fundamental trade-off in the clinical translation of bioelectronics lies between practical handleability ex vivo(pre-implantation)and the demand for mechanical conformability in vivo[6].To realize imperceptible biointerfaces-platforms avoiding mechanical stress or chronic tissue compression-devices must be nanoscale-thin and ultrasoft.Yet,such nanofilms are fragile and difficult to manipulate during conventional microfabrication and transfer steps,impeding their clinical translation and scalability. 展开更多
关键词 electronic systems biological tissuesenabling hydrogel elastomer soft bioelectronics biointerfaces conformal integration strategies conformal neural interfacesa conductive nanomembranes
Editorial for Special Issue on Biotribology and Biointerfaces 认领 引用
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作者 Jian Song Yuhong Liu Zhongxiao Peng 《Friction》 SCIE EI CAS CSCD 2025年第11期1-2,共2页
Biotribology and biointerfaces stand at the forefront of interdisciplinary tribological research,bridging tribology,materials science,biology,and medicine to address critical challenges in healthcare,implant technolog... Biotribology and biointerfaces stand at the forefront of interdisciplinary tribological research,bridging tribology,materials science,biology,and medicine to address critical challenges in healthcare,implant technology,and bioengineering.Over the past decade,the Friction Journal has published two special issues related to biotribology and biomedical tribology.Building on these studies,recent advances in biotribological mechanisms,biointerface engineering,and materials innovation—driven by cross-disciplinary collaborations—have led to the need for a third special issue. 展开更多
关键词 materials science materials innovation driven biotribology biointerfaces tribology medicine healthcare biology
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Direct Ink Writing 3D Printing of Hydrogel Bioelectronics 认领 引用 被引量：1
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作者 Yu Xue Fu-Cheng Wang +3 位作者 Qiao-Bo Wang Liang-Jie Shan Hui Li Ji Liu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第6期1667-1680,I0009,共14页
Direct-ink-writing(DIW)3D printing has emerged as an indispensable advanced manufacturing technology in biomedical engineering owing to its material compatibility,structural precision,and multimaterial integration cap... Direct-ink-writing(DIW)3D printing has emerged as an indispensable advanced manufacturing technology in biomedical engineering owing to its material compatibility,structural precision,and multimaterial integration capabilities.By digitally programming hydrogel ink deposition,DIW 3D printing enables the controllable fabrication of high-performance hydrogel bioelectronic devices featuring complex 3D architectures,high-fidelity electrophysiological recording/stimulation,and mechanical compliance with soft tissues,thereby establishing a technological foundation for next-generation personalized medical electronics.This review systematically summarizes the recent progress in DIW-printed hydrogel bioelectronics,first elaborating design strategies for hydrogel inks that reconcile printability with functionality through synergistic engineering of rheological behavior,electrical conductivity,tissue adhesion,and biocompatibility.We comprehensively analyzed state-of-the-art wearable and implantable devices fabricated via DIW 3D printing,highlighting their advantages in electrophysiological monitoring,precision stimulation,and biosensing.Finally,we conclude by critically evaluating the current challenges and future directions,thereby establishing a framework for DIW 3D printing to become a foundational platform for customized biointegrated interfaces. 展开更多
关键词 3D printing Direct-ink writing Hydrogel Bioelectronics Biointerface
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Engineering subcellular-patterned biointerfaces to regulate the surface wetting of multicellular spheroids 认领 引用 被引量：2
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作者 Luying Wang Pingqiang Cai +9 位作者 Jing Luo Feilong Zhang Jian Liu Yupeng Chen Zhongpeng Zhu Yongyang Song Bingquan Yang Xi Liu Xiaodong Chen Shutao Wang 《Nano Research》 SCIE EI CSCD 2018年第10期5704-5715,共12页
Studying the wetting behaviors of multicellular spheroids is crucial in the fields of embryo implantation, cancer propagation, and tissue repair. Existing strategies for controlling the wetting of multicellular sphero... Studying the wetting behaviors of multicellular spheroids is crucial in the fields of embryo implantation, cancer propagation, and tissue repair. Existing strategies for controlling the wetting of multicellular spheroids mainly focus on surface chemistry and substrate rigidity. Although topography is another important feature in the biological micro-environment, its effect on multicellular spheroid wetting has seldom been explored. In this study, the influence of topography on the surface wetting of multicellular spheroids was investigated using subcellular- patterned opal films with controllable colloidal particle diameters （from 200 to 1,500 nm）. The wetting of hepatoma carcinoma cellular （Hep G2） spheroids was impaired on opal films compared with that on flat substrates, and the wetting rate decreased as colloidal particle diameter increased. The decrement reached 48.5% when the colloidal particle diameter was 1,500 nm. The subcellular-patterned topography in opal films drastically reduced the cellular mobility in precursor films, especially the frontier cells in the leading edge. The frontier cells failed to form mature focal adhesions and stress fibers on micro-patterned opal films. This was due to gaps between colloidal particles leaving adhesion vacancies, causing weak cell-substrate adhesion and consequent retarded migration of Hep G2 spheroids. Our study manifests the inhibiting effects of subcellular-patterned topography on the wetting behaviors of multicellular spheroids, providing new insight into tissue wetting-associated treatments and biomaterial design. 展开更多
关键词 topography wetting multicellular spheroids cell adhesion collective migration biointerfaces
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Chiral polymer-based biointerface materials 认领 引用 被引量：5
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作者 LI MinMin QING GuangYan +1 位作者 ZHANG MingXi SUN TaoLei 《Science China Chemistry》 SCIE EI CAS 2014年第4期540-551,共12页
Chirality is a unique phenomenon in nature. Chiral interactions play an important role in biological and physiological process- es, which provides much inspiration for scientists to develop cbiral materials. As a brea... Chirality is a unique phenomenon in nature. Chiral interactions play an important role in biological and physiological process- es, which provides much inspiration for scientists to develop cbiral materials. As a breakthrough from traditional materials, bi- ointerface materials based on chiral polymers have attracted increasing interest over the past few years. Such materials ele- gantly combine the advantages of chiral surfaces and traditional polymers, and provide a novel solution not only for the inves- tigation of chiral interaction mechanisms but also for the design of biomaterials with diverse applications, such as in tissue en- gineering and biocompatible materials, bioregulation, chiral separation and chiral sensors. Herein, we summarize recent ad- vances in the study of chiral effects and applications of chiral polymer-based biointerface materials, and also present some challenges and perspectives. 展开更多
关键词 chirality polymer chiral interaction biointerface materials chiral effects applications
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Characterization and manipulation of the photosystem Ⅱ-semiconductor interfacial molecular interactions in solar-to-chemical energy conversion 认领 引用
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作者 Min He Wangyin Wang +7 位作者 Zheyi Liu Wenxiang Zhang Jinan Li Wenming Tian Ye Zhou Yan Jin Fangjun Wang Can Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第7期437-443,I0012,共7页
Semi-artificial photosynthesis interfacing catalytic protein machinery with synthetic photocatalysts exhibits great potential in solar-to-chemical energy conversion. However, characterizing and manipulating the molecu... Semi-artificial photosynthesis interfacing catalytic protein machinery with synthetic photocatalysts exhibits great potential in solar-to-chemical energy conversion. However, characterizing and manipulating the molecular integration structure at the biotic-abiotic interface remain a challenging task. Herein,the biointerface molecular integration details of photosystem II(PSII)-semiconductor hybrids, including the PSII orientation, interfacial microdomains, and overall structure modulation, are systematically interrogated by lysine reactivity profiling mass spectrometry. We demonstrate the semiconductor surface biocompatibility is essential to the PSII self-assembly with uniform orientation and electroactive structure.Highly directional localization of PSII onto more hydrophilic Ru/Sr Ti O3:Rh surface exhibits less disturbance on PSII structure and electron transfer chain, beneficial to the high water splitting activity.Further, rational modification of hydrophobic Ru2S3/Cd S surface with biocompatible protamine can improve the hybrid O2-evolving activity 83.3%. Our results provide the mechanistic understanding to the structure–activity relationship of PSII-semiconductor hybrids and contribute to their rational design in the future. 展开更多
关键词 PSII-semiconductor hybrids Biointerface molecular interaction Solar-to-chemical energy conversion Mass spectrometry Lysine reactivity profiling
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Custom-Tailored Nanofunctionalized Cells by Phase-Separated Lysozyme 认领 引用
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作者 Tong-Kai Zhang Wei Geng +11 位作者 Yao-Qi Huang Zi-Qian Yi Xuan Wu Li-Ying Wang Ling Shen Si-Ming Wu Yi Lu Jie Ying Fa-Zhou Wang Ge Tian Jan C.Mvan Hest Xiao-Yu Yang 《CCS Chemistry》 CSCD 2026年第2期1055-1069,共15页
Although great progress has been made in devising new methods for cell engineering,uncovering universal and highly biocompatible approaches to nanofunctionalizing cells for creating novel cell-based living biomaterial... Although great progress has been made in devising new methods for cell engineering,uncovering universal and highly biocompatible approaches to nanofunctionalizing cells for creating novel cell-based living biomaterials with enhanced stabilities and functions remains an important goal.Here,we developed a phase separated lysozyme(PSL)-based strategy for generating functionalized HeLa cells with high stability and resistance to trypsin action.Due to the rich functional groups,PSL nanocoating on the HeLa cell surface could serve as a biointerface for customtailored functionalization with nanomaterials of oxides,carbon,semiconductor,and metals to create biotic-abiotic living materials.Significantly,this PSL-based strategy could be applied to mammalian,algal,and bacterial cells for applications with precise functions from nanomaterials.Overall,this study identified a rational and general strategy to create nanofunctionalized cells with precise functions expected to pave the way to opportunities in synthesizing living biomaterials based on the phase separation proteins. 展开更多
关键词 nanofunctionalized cells phase-separated lysozyme biointerface stability custom-tailored nanofunctionalization
Multifunctional Coating Based on Hyaluronic Acid Loaded With a Traditional Chinese Medicine Ingredient,Ophiopogon Saponin D,for Potential Application of Cardiovascular Stents 认领 引用
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作者 Jingan Li Kun Zhang +3 位作者 Xiaojing Sun Zhongna Zhang Xiao Luo Shaokang Guan 《Biosurface and Biotribology》 EI 2026年第1期86-98,共13页
Cardiovascular disease(CVD)is regarded as the leading cause of morbidity and mortality worldwide within recent decades.Stent intervention is one of the main methods for treating CVD due to its advantages of minimal tr... Cardiovascular disease(CVD)is regarded as the leading cause of morbidity and mortality worldwide within recent decades.Stent intervention is one of the main methods for treating CVD due to its advantages of minimal trauma,fast recovery and fewer complications.However,the main function of existing drug-eluting stents is anti-hyperplasia,and their re-endothelialisation function is still insufficient and needs to be strengthened.In this study,a novel coating containing traditional Chinese medicine ingredient,Ophiopogon Saponin D(OPH),is designed to enhance the re-endothelialisation function of stents:firstly,the dopamine(DA)and hexanediamine(HD)were co-polymerised to the bare metal stent,endowing rich-amino surface(PDA/HD)for conjugating functional molecules by chemical reaction;thereafter hyaluronic acid(HA)containing OPH were conjugated to the PDA/HD.Our data suggested that the OPH coating promoted surface re-endothelialisation not only by directly enhancing proliferation/migration and inhibiting apoptosis of endothelial cells,but also by regulating macrophages to M2 phenotype and smooth muscle cells to contractile phenotype.Our study may provide inspiration for designing more novel biomaterial coatings using traditional Chinese medicine ingredient. 展开更多
关键词 biocompatibility biointerface biomaterials cardiovascular device coatings
Piezoionics:Strategies and applications for mechanical-to-ionic transduction 认领 引用
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作者 Yao Chen Sufang Guo +1 位作者 Kaixuan Teng Qi An 《Nano Research》 SCIE EI CSCD 2026年第4期760-773,共14页
The piezoionic effect refers to the generation of high ionic currents due to ionic polarization caused by the differentiated movement of cations and anions in polymer electrolytes under gradient deformation.This novel... The piezoionic effect refers to the generation of high ionic currents due to ionic polarization caused by the differentiated movement of cations and anions in polymer electrolytes under gradient deformation.This novel power generation mechanism resembles physiological electricity and shows great promise in bio-related applications.The field of piezoionics benefits from the excellent designability of flexible polymeric materials in terms of their functionality and properties.In this review,the universal basic principles of piezoionics are described first.Subsequently,we summarize four strategies for enhancing net ionic flux through advanced material engineering:structural design optimization,interface engineering,phase separation control,and ion selectivity enhancement.Furthermore,we summarize the current applications in sensing and biointerface technology,as well as provide a prospective analysis of existing challenges and technical limitations for future development.Overall,this review aims to demonstrate the comprehensive development of novel piezoionics and accelerate the transition of these materials from basic research to practical applications. 展开更多
关键词 piezoionics enhancement strategy sensing biointerface
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Electrostatically Assembled HA-DN/AMSN-TCS Coatings for Antibacterial Urinary Catheters 认领 引用
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作者 Jiafeng Hu Xiaojun Chen +2 位作者 Yingwei Chen Lin Wu Chengxiong Lin 《Biosurface and Biotribology》 EI 2026年第1期1-10,共10页
Catheter-associated urinary tract infections(CAUTIs)are a significant complication of indwelling urinary catheters,primarily caused by bacterial adhesion,biofilm formation and catheter-induced mechanical irritation.To... Catheter-associated urinary tract infections(CAUTIs)are a significant complication of indwelling urinary catheters,primarily caused by bacterial adhesion,biofilm formation and catheter-induced mechanical irritation.To reduce the risk of infection and enhance catheter safety and performance,this study developed an antibacterial lubricating coating.The coating was fabricated on a polytetrafluoroethylene(PTFE)substrate via electrostatic self-assembly,combining dopamine-modified hyaluronic acid–dopamine(HA–DN)as a biomimetic adhesive with aminated mesoporous silica nanoparticles(AMSN)serving as a long-acting drug delivery carrier loaded with triclosan(TCS).The results demonstrated that the prepared AMSN exhibited a uniform particle size of approximately 80 nm,an ordered mesoporous structure and a high drug-loading capacity,enabling sustained in vitro release of TCS for up to 144 h.Additionally,the composite multilayer coating significantly improved surface hydrophilicity and lubricity,exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus and maintained good biocompatibility.These findings highlight its potential for preventing CAUTIs and enhancing the safety of indwelling urinary catheters. 展开更多
关键词 adhesion and friction antifungi antimicrobial biointerface biological adhesion
Stimuli-Responsive Hydrogels for Optical Applications:Mechanisms,Architectures,and Translational Challenges 认领 引用
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作者 Andrés Bernal-Ballén Alexandr Dejneka Oleg Lunov 《Aggregate》 EI CAS CSCD 2026年第6期69-112,共44页
The use of stimuli-responsive hydrogels in optoelectronics holds promise due to their capacity to turn chemical or physical stimuli into optical signals by virtue of network dynamics,swelling equilibria,and microstruc... The use of stimuli-responsive hydrogels in optoelectronics holds promise due to their capacity to turn chemical or physical stimuli into optical signals by virtue of network dynamics,swelling equilibria,and microstructure.This review provides an insight into the chemistry and microarchitecture of hydrogels that influence optical transduction via refractive index modulation,scattering,birefringence,diffraction,and transparency.The review also highlights the important classes of stimuli involved in adaptive optics,including light,temperature,magnetic fields,ionic environment,metabolites,and enzymes.The hierarchical structuring,nanocomposites,and photonic structures can be used to modulate the magnitude of these responses.An important finding is that the limitations in designing stimuli-responsive devices are not necessarily linked to the sensitivity of the material but rather with the challenge of combining optical quality,mechanical strength,reversibility,and stability in real-world environments.Another important challenge is the absence of standardized criteria for measuring optical modulation,kinetic response,fatigue,and biostability.Future research will rely on data-driven strategies,such as polymer informatics and machine learning. 展开更多
关键词 biointegrated optics biophotonics optical biointerfaces smart hydrogels stimuli-responsive hydrogels
The role of epithelial-mesenchymal interfacial tension in biological systems 认领 引用
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作者 Ivana Pajic-Lijakovic Milan Milivojevic Peter V.E.McClintock 《Frontiers of physics》 SCIE CSCD 2025年第4期83-101,共19页
The interfacial tension between two cell subpopulations in direct contact represents a key physical parameter responsible for the self-organization of tissues during biological processes such as morphogenesis and the ... The interfacial tension between two cell subpopulations in direct contact represents a key physical parameter responsible for the self-organization of tissues during biological processes such as morphogenesis and the spreading of cancers.Higher interfacial tension(i)reduces the spreading of cancer-mesenchymal cells through the epithelial subpopulation,(ii)ensures efficient cell segregation in co-cultured systems,(iii)can induce extrusion of cancer-mesenchymal cells along the biointerface with the epithelial subpopulation,and(iv)results in the generation of higher mechanical stress along the biointerface.Inhomogeneous distribution of the interfacial tension leads to the Marangoni effect,which further facilitates the rearrangement of cells.The formation of mobile stiffness gradients,known as durotaxis,under in vivo conditions is directly related to an inhomogeneous distribution of the interfacial tension.As the product of homotypic and heterotypic cell-cell interactions,the interfacial tension depends on the distance between the subpopulations,which varies over time.This review(i)summarizes biological aspects related to the homotypic and heterotypic cell-cell interactions along the biointerface,together with the viscoelasticity of cell subpopulations caused by collective cell migration and by compression(de-wetting)/extension(wetting)of the subpopulations;and(ii)describes these same biological aspects from a biophysical/mathematical perspective by pointing to the role played by the interfacial tension. 展开更多
关键词 collective cell migration cell residual stress accumulation tissue surface tension Marangoni effect viscoelasticity effects along the biointerface
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Harnessing the power of physicochemical material property screening to direct breast epithelial and breast cancer cells 认领 引用
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作者 Lisa E.Tromp Rik de Jong +4 位作者 Torben A.B.van der Boon Alejandro Reina Mahecha Ruud Bank Jan de Boer Patrick van Rijn 《Bioactive Materials》 SCIE CSCD 2025年第8期494-509,共16页
Understanding cell-material interactions is crucial for advancing biomedical applications,influencing cellular behavior and medical device performance.Material properties can be manipulated to direct cell responses,be... Understanding cell-material interactions is crucial for advancing biomedical applications,influencing cellular behavior and medical device performance.Material properties can be manipulated to direct cell responses,benefiting applications from regenerative medicine to implantable devices such as silicone breast implants.Knowledge about the interaction differences between healthy and cancer cells with implants may guide implant design to more precisely influence cell adhesion and proliferation of healthy cells while inhibiting cancer cells,tailoring outcomes to specific cellular responses.To show-case this potential,breast epithelial cells and breast cancer cells were investigated regarding their interaction with a broad range of combined physicochemical properties.This study employed a silicone-based high-throughput screening method utilizing Double Orthogonal Gradients(DOGs)to investigate the influence of topography,stiffness,and wettability on breast epithelial cells(MCF10a)and breast cancer cells(MCF7).Results show distinct cellular responses,including decreased prolif-eration rates in both MCF10a and MCF7 cells with the introduction of surface topography and the dominant influence of wettability on cell adhesion,proliferation,and cluster formation.The screening identified specific regions of interest(ROIs)where MCF10a cell proliferation outperformed MCF7 cells and that topography inhibits cluster formation(tumorigenesis),offering potential prospects for the creation of novel implant surfaces. 展开更多
关键词 High-throughput screening Biointerfaces Breast implants
Toward Ideal Biointerfacing Electronics Using Organic Electrochemical Transistors 认领 引用
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作者 Peiyun Li Ting Lei 《Accounts of Materials Research》 CAS CSCD 2025年第7期853-864,共12页
CONSPECTUS:The biointerface between biological tissues and electronic devices serves as a medium for matter transport,signal transmission,and energy conversion.However,significant disparities in properties,such as mec... CONSPECTUS:The biointerface between biological tissues and electronic devices serves as a medium for matter transport,signal transmission,and energy conversion.However,significant disparities in properties,such as mechanical modulus and water content,between tissues and electronics,present a key challenge in bioelectronics,leading to biointerface mismatches that severely impact their performance and long-term stability.Organic electrochemical transistors(OECTs),fabricated with soft,hydrophilic organic semiconductors,offer unique advantages,including low operating voltage,high transconductance,and compatibility with aqueous environments. 展开更多
关键词 bioelectronics biointerfacing organic electrochemical transistors biointerface mismatches biological tissues mechanical modulus electronics electrochemical transistors oects fabricated
Fast and low-cost determination of prostate-specific antigen using paper-based immunodevice modified with Cu@CuS@Au NPs nanocages 认领 引用
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作者 Yi Duan Qi Wu +3 位作者 Jiangtao Lin Yourong Duan Qi Wang Yuanyuan Li 《Biosurface and Biotribology》 EI 2025年第1期1-9,共9页
In this study,the authors designed a paper-based electrochemical immunodevice modified with copper embedded in copper sulphide hollow nanocages wrapped with Au nanoparticles(Cu@CuS@Au NPs)for the specific detection of... In this study,the authors designed a paper-based electrochemical immunodevice modified with copper embedded in copper sulphide hollow nanocages wrapped with Au nanoparticles(Cu@CuS@Au NPs)for the specific detection of prostate-specific antigen(PSA),aiming to advance point-of-care testing.The large specific surface area of Cu@CuS nanocages enables efficient capture of biotin antibodies,leading to the direct amplification of the signal through the inhibition of electron transport in the redox process of Cu,eliminating the need for universal redox electron mediators.Additionally,Au NPs on the surface of Cu@CuS can accelerate charge transfer and conjugate with anti-PSA.The hierarchical morphology and structure of Cu@CuS nanocages were characterised using scanning electron microscopy and transmission electron microscopy.The fabrication process of the immunodevice was monitored using cyclic voltammetry and electrochemical impedance spectroscopy analyses.PSA was sensitively detected using differential pulse voltammetry on this proposed immunodevice within a linear range from 0 to 100 ng/ml(R2=0.996),achieving a low detection limit of 0.077 ng/ml.In addition,the practicality of the developed immunosensor has been proven by successfully detecting PSA in human serum samples obtained from clinical settings.The integration of electrochemical sensors and microfluidic devices holds promise for developing cost-effective approaches in clinical immunoassays. 展开更多
关键词 biointerface electrochemical impedance spectroscopy
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