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Hierarchical N,S co-doped Fe3O4/C nanotubes constructed by ultrathin nanosheets for superior Li-ion batteries 认领 引用 被引量：2
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作者 Fucong Lyu Shanshan Zeng +14 位作者 Ligang Sun Feixiang Ma Shaoran Yang Zebiao Li Lu Yao Fengqian Hao Zhe Jia Xufen Xiao Hongkun Li Aiwu Wang Guo Liu Yang Yan Yawen Zhan Yangyang Li Jian Lu 《Nano Materials Science》 EI CAS CSCD 2026年第3期641-650,共10页
In the present work,a facile strategy of synthesizing ultrathin nanosheets constructed N,S co-doped Fe3O4/C nanotubes via annealing the methyl orange-embedded Fe-glycerate nanotubes is reported.The nanosheet,con... In the present work,a facile strategy of synthesizing ultrathin nanosheets constructed N,S co-doped Fe3O4/C nanotubes via annealing the methyl orange-embedded Fe-glycerate nanotubes is reported.The nanosheet,constituting the wall of the nanotube,is formed by small Fe3O4 nanoparticles enchased highly graphitic carbon at a graphitization temperature as low as 450℃.The nanosheets constructed N,S co-doped Fe3O4/C nanotubes exhibited superior electrochemical performance due to the highly accelerated intercalation/deintercalation rate of Li+ ions resulting from the homogeneous N and S dopants,greatly buffered volume expansion resulting from the abundant micro/meso-pores and hieratical nanosheet organized nanotube structure,and the good conductivity resulting from the graphitic carbon coating.Density functional theory(DFT)verified that N,S doping can efficiently promote the adsorption of Li+ ions thus accelerated the intercalation/deintercalation rate of Li+ ions. 展开更多
关键词 N S co-doped Fe3O4/C nanotubes Ultrathin nanosheets Low temperature graphitization Promoting Liþadsorption Li-ion batteries
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膜肾方调控C3a/C3aR通路对特发性膜性肾病大鼠血浆诱导损伤足细胞的影响 认领 引用 被引量：1
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作者 丁秀 李慧 +3 位作者 刘会彬 吴成态 王小琴 邹新蓉 《中医药导报》 2026年第3期1-5,共5页
目的:探讨膜肾方对特发性膜性肾病大鼠血浆诱导损伤足细胞的干预作用及其机制。方法:建立特发性膜性肾病大鼠模型,用肝素钠作为抗凝剂收集其血浆样品并诱导足细胞损伤,分对照组、模型组、膜肾方组、膜肾方+C3a受体(C3aR)拮抗剂组、C3aR... 目的:探讨膜肾方对特发性膜性肾病大鼠血浆诱导损伤足细胞的干预作用及其机制。方法:建立特发性膜性肾病大鼠模型,用肝素钠作为抗凝剂收集其血浆样品并诱导足细胞损伤,分对照组、模型组、膜肾方组、膜肾方+C3a受体(C3aR)拮抗剂组、C3aR拮抗剂组。采用Western blotting检测各组足细胞C3aR、磷脂酶A2受体(PLA2R)、磷酸化细胞外信号调节激酶1/2(p-ERK1/2)、磷酸化细胞浆型磷脂酶A2(p-cPLA2)蛋白表达水平;酶联免疫吸附试验(ELISA)检测上清液C3a表达水平;Real-time PCR测定Synaptopodin mRNA、C3aR m RNA、PLA2R mRNA表达水平;细胞计数试剂盒-8(CCK-8)检测各组足细胞活力。结果:与对照组比较,模型组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均升高,上清液C3a水平升高,Synaptopodin m RNA水平下降,C3aR mRNA、PLA2R mRNA水平升高,足细胞活力下降,差异均有统计学意义(P<0.01);与模型组比较,膜肾方组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin m RNA水平升高,C3aR mRNA、PLA2R mRNA水平下降,足细胞活力改善,差异均有统计学意义(P<0.01);与膜肾方组比较,膜肾方+C3aR拮抗剂组及C3aR拮抗剂组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin mRNA水平升高,C3aR m RNA、PLA2R mRNA水平下降,足细胞活力改善,膜肾方+C3aR拮抗剂组更明显,差异均有统计学意义(P<0.01)。结论:膜肾方可能通过调控C3a/C3aR通路,下调PLA2R水平,稳定足细胞骨架,改善足细胞活力,从而发挥对足细胞的保护作用。 展开更多
关键词 特发性膜性肾病 膜肾方 足细胞 C3a/C3aR通路
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柴胡疏肝散抑制C3/C3aR介导小胶质细胞M1极化改善绝经综合征肝郁证模型小鼠的海马突触可塑性 认领 引用
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作者 钟瑶 蔡晓诗 +9 位作者 李欣媛 王素英 吴忧 陈朝玺 王悦 沈冰榕 龚琳 沈建英 闵莉 梁文娜 《南方医科大学学报》 CAS CSCD 北大核心 2026年第8期1823-1834,共12页
目的探讨柴胡疏肝散调节C3/C3aR介导M1型小胶质细胞极化改善绝经综合征(MPS)肝郁证的作用机制。方法将56只SPF级雌性C57BL/6小鼠按照体质量分层随机分为假手术组(n=13)和去势手术组(n=43)。手术过程中假手术组小鼠死亡1只,去势手术组小... 目的探讨柴胡疏肝散调节C3/C3aR介导M1型小胶质细胞极化改善绝经综合征(MPS)肝郁证的作用机制。方法将56只SPF级雌性C57BL/6小鼠按照体质量分层随机分为假手术组(n=13)和去势手术组(n=43)。手术过程中假手术组小鼠死亡1只,去势手术组小鼠死亡4只、3只造模未成功,故予以剔除。去势手术组小鼠摘除双侧卵巢建立绝经期模型后,再分为绝经组、绝经肝郁组和柴胡疏肝散组,12只/组。其中,绝经肝郁组和柴胡疏肝散组均采用双侧卵巢去势联合慢性温和不可预知应激(CUMS)法建立MPS肝郁证模型。柴胡疏肝散组给予6.47 g/kg柴胡疏肝散混悬液灌胃28 d,其余各组小鼠灌胃等剂量生理盐水。通过阴道脱落细胞涂片和行为学评价模型;ELISA法检测血清性激素、神经递质,血清和海马炎症因子水平;HE染色法观察海马组织形态;高尔基染色法观察海马神经元树突棘形态;免疫荧光法检测海马CA1区小胶质细胞相关标志物、突触可塑性相关蛋白;Western blotting检测海马补体C3(C3)/补体C3a受体(C3aR)通路相关蛋白。结果与假手术组比较,去势小鼠动情周期紊乱,绝经肝郁组小鼠表现出抑郁样行为(P<0.01);血清性激素和神经递质水平异常(P<0.01),血清和海马炎症因子含量增加(P<0.01);海马CA1区神经元细胞数量减少、排列紊乱且核固缩,树突棘数量减少;海马CA1区小胶质细胞相关标志物表达增加(P<0.01)、突触可塑性相关蛋白荧光表达降低(P<0.01);C3/C3aR通路相关蛋白表达增加(P<0.05,P<0.01)。与绝经肝郁组比较,柴胡疏肝散干预后可改善MPS肝郁小鼠的抑郁样行为(P<0.05,P<0.01);血清性激素和神经递质水平逆转(P<0.05,P<0.01),血清和海马炎症因子含量降低(P<0.01);海马CA1区神经元细胞数量增加、排列有序,树突棘数量增加、形态改善;海马CA1区小胶质细胞相关标志物表达逆转,突触可塑性相关蛋白荧光强度增强(P<0.01);海马C3/C3aR通路相关蛋白表达下调(P<0.05,P<0.01)。结论柴胡疏肝散可以改善MPS肝郁模型小鼠海马突触可塑性,其作用机制与抑制C3/C3aR信号通路介导小胶质细胞M1极化有关。 展开更多
关键词 绝经综合征 肝郁证 柴胡疏肝散 小胶质细胞 C3/C3aR信号通路
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Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway 认领 引用
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作者 Lu Ding Xinyue Li +2 位作者 YaQin Guo Feng-Quan Zhou David Y.B.Deng 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期153-174,共22页
Activation of spinal cord neural stem cells(NSCs)and subsequent neurogenesis holds a promising alternative for spinal cord injury(SCI)repair.Our previous study demonstrated that complement C3a,derived from reactive as... Activation of spinal cord neural stem cells(NSCs)and subsequent neurogenesis holds a promising alternative for spinal cord injury(SCI)repair.Our previous study demonstrated that complement C3a,derived from reactive astrocytes,inhibits NSC proliferation by suppressing protein aggregate clearance through the deubiquitinating enzyme ubiquitin carboxy-terminal hydrolase L1(UCHL1)-proteasome system post-SCI.However,the potential molecular mechanism by which C3a modulates NSC activation via this pathway remains unclear.Here,we revealed that C3a/C3a receptor(C3aR)signaling activated NF-κB p65,which in turn inhibited Nrf2 activity and UCHL1 expression,resulting in diminished proteasome activity and the accumulation of protein aggregates,and ultimately impaired NSC activation.Both knockdown of NF-κB p65 and Nrf2 upregulation restored UCHL1 expression and proteasome activity in vitro,promoting NSC activation by enhancing protein aggregate clearance.Mechanistically,we found that NF-κB p65 regulated Nrf2 activity through a dual mechanism:(1)promoting Keap1-dependent ubiquitination and proteasome degradation of Nrf2;(2)inhibiting protein kinase C-mediated Nrf2 phosphorylation and nuclear translocation.Using the dual-luciferase reporter assay and chromatin immunoprecipitation(ChIP)analysis,we further identified UCHL1 as a direct transcriptional target of Nrf2.Importantly,in vivo experiments using SCI mice confirmed that either C3aR blockade,NF-κB p65 knockdown,or Nrf2 overexpression could rescue SCI-induced UCHL1 downregulation.Together,this study uncovers the C3a-NF-κB p65-Nrf2-UCHL1-proteasome axis as a critical regulator of NSC activation after SCI.This may provide novel molecular targets and intervention strategies for SCI repair. 展开更多
关键词 Complement C3a Neural stem cell activation UCHL1 NF-κB p65/Nrf2 pathway Protein aggregation clearance Spinal cord injury
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Enhanced hole-proton-coupled electron transfer of spin polarized photocatalyst via Mo-S4coordination for sequential activation of C(sp3)-H and O-H bonds 认领 引用
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作者 Xiaoping Wang Bowen Yang +4 位作者 Haoye Wang Haixin Guo Richard Lee Smith Jr Yaqiong Su Xinhua Qi 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第4期189-199,I0006,共11页
Photocatalytic oxidative dehydrogenation of biomass feedstocks offers the possibility for synthesizing value-added chemicals,but the sluggish transport kinetics and rapid recombination of photogenerated charge carrier... Photocatalytic oxidative dehydrogenation of biomass feedstocks offers the possibility for synthesizing value-added chemicals,but the sluggish transport kinetics and rapid recombination of photogenerated charge carriers constrain photocatalysis efficiency.Spin-polarized photocatalysts,by accelerating the separation of photogenerated electrons and holes,offer a promising strategy for selective biomass valorization.Herein,polarization unit Mo was incorporated into ZnIn2S4(ZIS)with S-vacancy through Mo-S4coordination(Mo-Vs-ZIS)to enhance hole and proton-coupled electron transfer(PCET).Mo-Vs-ZIS spin polarized photocatalyst applied to 5-hydroxymethylfurfural(HMF)afforded a 2,5-diformylfuran(DFF)selectivity of 92.3%at a production rate of 1105.3μmol gcat-1h-1,attributed to carrier transport and reaction processes.The Mo-Vs-ZIS photocatalyst efficiently(100 min)converted benzyl and furfuryl alcohols,aromatic alcohols bearing electron-rich substituents,and halogen-substituted aromatic alcohols into their corresponding aldehydes.Piezoelectric force microscopy(PFM)and Kelvin probe force microscopy analyses(KPFM)revealed that the full-space polarized electric field was formed to drive directional transfer of photogenerated carriers,facilitating bulk-to-surface charge separation.Moreover,Mo-Vs-ZIS showed high Bader charge transfer to O2,where Mo atomic sites functioned as an electron reservoir,driving the activation of O2to form•O2,a kinetically favorable step for HMF oxidation and induced transfer of holes to activate C(sp3)-H bonds,which is a rate-determining step.Then,the critical step of PCET(O2+H+→•OOH)over Mo-Vs-ZIS gave•OOH for O-H activation to complete the reaction sequence.This spin-polarized modification strategy featuring atomic-level catalytic sites enables its application to other semiconductor photocatalysts for biomass conversion. 展开更多
关键词 Photooxidation C(sp3)-H activation Mo-Vs-ZIS Spin polarization Proton-coupled electron transfer
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Recent advanced in C–H borylation using BX3with different directing group auxiliary 认领 引用
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作者 Gaorong Wu Tao Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期171-179,共9页
Organoboron compounds have garnered significant attention in the fields of organic synthesis,materials science,medicinal chemistry and fine chemicals.In the past few decades,transition metal-catalyzed C–H borylation ... Organoboron compounds have garnered significant attention in the fields of organic synthesis,materials science,medicinal chemistry and fine chemicals.In the past few decades,transition metal-catalyzed C–H borylation has been developed rapidly and efficiently.In recent years,in order to explore eco-friendly,economical and efficient method for constructing C–B bond,chemists are dedicated to developing metalfree BX3-mediated borylation.In this review,we present a systematic and comprehensive overview of the borylation driven by BX3 with different directing group auxiliary in the fields of organic synthesis and boron-containing organic materials since 2010,including(1)nitrogen directed C–H borylation,(2)oxygen directed C–H borylation,(3)sulfur directed C–H borylation and(4)phosphorus directed C–H borylation.The methods of borylation processes as well as the substance scopes,limits,and mechanisms of these routes are also discussed. 展开更多
关键词 Organoboron C–H Borylation BX3 Directing group Organic synthesis
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Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model 认领 引用
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作者 Yangyun Guo Ziheng Yan +4 位作者 Jingyu Ye Ruifu Yang Yajun Song Hui Yue Yong Zhao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第7期1292-1301,共10页
Background:Ulcerative colitis(UC)is a typical inflammatory bowel disease requiring long-term management.Although fecal calprotectin(FC)is widely employed for assessing disease activity,it is still considered insuffici... Background:Ulcerative colitis(UC)is a typical inflammatory bowel disease requiring long-term management.Although fecal calprotectin(FC)is widely employed for assessing disease activity,it is still considered insufficient as a standalone tool.New biomarkers are needed to better predict risk and comprehensively reflect biological pathways.This study aimed to identify potential fecal biomarkers to monitor disease activity in UC.Methods:C57BL/6J mice were exposed to dextran sulfate sodium(DSS)treatment for 7 days.Feces were collected and subjected to proteomic analysis and enzyme-linked immunosorbent assay(ELISA).Mouse colon tissues were subjected to histopathological and immunofluorescence analyses.The correlations between the selected fecal proteins and disease severity were evaluated and compared with FC.Results:Proteomic analysis revealed increases in fecal complement component 3(C3)and fibronectin(FN)in the DSS group.Next,we measured fecal C3 and FN levels in mice using ELISA.Significant elevation in C3 and FN levels was observed as early as day 1 after DSS treatment,preceding the increase in FC.Both fecal C3 and FN demonstrated significant correlations with disease activity,with C3 exhibiting a stronger correlation than FC.Using immunofluorescence,we observed distinct C3 and FN expressions in both the colonic tissues and the intestinal lumen.Conclusion:These findings demonstrate that fecal C3 and FN are promising candidate biomarkers for monitoring UC disease activity,and their utility requires further validation in other colitis models and human cohorts. 展开更多
关键词 complement component 3(C3) disease activity fibronectin mouse model ulcerative colitis
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Hollow tubular In2O3modified carbon nitride for photocatalytic high-yield cleavage of lignin C-C bonds under 395 nm light 认领 引用
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作者 Yixin Li Jianhao Qiu +5 位作者 Guanglu Xia Qiying Liu Biyao Fang Meng Liu Chen Chen Jianfeng Yao 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第4期209-218,共10页
The selective cleavage of Cα-Cβbonds is of great significance to lignin valorization,and photocataly-sis offers an eco-friendly pathway to achieve this process.Here,graphitic carbon nitride(g-C3N4)modifi... The selective cleavage of Cα-Cβbonds is of great significance to lignin valorization,and photocataly-sis offers an eco-friendly pathway to achieve this process.Here,graphitic carbon nitride(g-C3N4)modified with hollow tubular In2O3was constructed via the calcination method for the photocatalytic cleavage of lignin Cα-Cβbonds.MIL-68(In)was used as the precursor of In2O3,imparting a unique hollow tubular structure and a relatively large specific surface area.The hollow tubular structure is helpful for light penetration and scattering,as well as rapid migration of the lignin substrate.The Z-scheme g-C3N4/In2O3heterojunction exhibited 92.1% conversion(corresponding benzaldehyde yield:82.4%)of the lignin model compound 2-phenoxy-1-phenylethanol(PP-ol),outperforming pure In2O3and g-C3N4by 40-and 2.3-fold,respectively,under 395 nm light illumination.By varying the illumination wavelength,the conversion and yields of the g-C3N4/In2O3composites were found to follow wavelength-dependent reactivities.Additionally,photogenerated holes are capable of converting PP-ol into benzoic acid,whereas1O2mainly converts PP-ol into benzaldehyde.This work could encourage the application of metal-organic frameworks in biomass conversion and provide insight into photocatalytic lignin valorization. 展开更多
关键词 Lignin C-C bond cleavage Photocatalysis Metal-organic frameworks g-C3N4 In2O3
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空气细颗粒物通过C3a/C3aR轴诱导鼻黏膜上皮间质转化 认领 引用
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作者 梁爽 闫冰 +2 位作者 李颖 王成硕 张罗 《首都医科大学学报》 CAS 北大核心 2026年第4期692-699,共8页
目的探究补体成分3(complement component 3a,C3a)/C3a受体(C3a receptor,C3aR)轴在空气细颗粒物(fine particulate matter,PM2.5)诱导慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)上皮间质转化(epithelial... 目的探究补体成分3(complement component 3a,C3a)/C3a受体(C3a receptor,C3aR)轴在空气细颗粒物(fine particulate matter,PM2.5)诱导慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)上皮间质转化(epithelialmesenchymal transition,EMT)中的作用。方法人原代鼻黏膜上皮细胞(human primary nasal epithelial cells,HPNECs)暴露于50μg/mL PM2.5后,利用免疫荧光法检测细胞中上皮标志物E-钙黏蛋白和间质标志物波形蛋白表达。获取公共数据集(GSE220165和GSE36830)分析钙黏蛋白1和波形蛋白表达,并利用Spearman相关性分析C3aR与EMT相关分子[钙黏蛋白1、波形蛋白、锌指E-box结合同源盒蛋白2(zinc finger E-box binding homeobox 2,ZEB2)]、基质金属蛋白酶9[matrix metallopeptidase 9,MMP9)]的相关性。蛋白免疫印迹法检测C3a和C3aR蛋白水平。并利用C3aR拮抗剂处理HPNECs,利用免疫荧光和蛋白免疫印迹法检测EMT相关分子的表达。结果PM2.5暴露下调HPNECs中E-钙黏蛋白表达,上调波形蛋白表达,与公共数据集分析结果一致。PM2.5暴露增加HPNECs中C3a和C3aR的蛋白水平。C3aR表达与EMT相关分子ZEB2(r=0.497,P=0.0144)、MMP9(r=0.409,P=0.0485)呈正相关,与波形蛋白呈正相关趋势,但差异无统计学意义(r=0.377,P=0.0699)。而C3aR拮抗剂处理可缓解PM2.5诱导的E-钙黏蛋白下调及波形蛋白、ZEB2和MMP9表达增加。结论PM2.5可通过补体C3a/C3aR轴促进CRSwNP鼻黏膜上皮发生EMT。 展开更多
关键词 空气细颗粒物 慢性鼻窦炎伴鼻息肉 人原代鼻上皮细胞 补体成分C3 补体成分C3a受体拮抗剂 上皮间质转化
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Electrospun Li3V2(PO4)3/carbon nanofibers as freestanding cathodes for high-performance zinc-ion batteries 认领 引用
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作者 Ding Honggeng Ren Yueyue +1 位作者 Zhang Yi Zhao Hongyang 《新型炭材料（中英文）》 SCIE EI CSCD 北大核心 2026年第1期173-183,I0031-I0036,共11页
Li3V2(PO4)3 is a promising high-voltage cathode for zincion batteries,but it suffers from a poor electronic conductivity and vanadium dissolution in aqueous electrolytes.The growth of carboncoated Li3V_... Li3V2(PO4)3 is a promising high-voltage cathode for zincion batteries,but it suffers from a poor electronic conductivity and vanadium dissolution in aqueous electrolytes.The growth of carboncoated Li3V2(PO4)3(LVP@C)nanoparticles on carbon nanofibers(CNFs)has been achieved by an electrospinning technique followed by calcination.The protective carbon coating prevents the aggregation of the LVP nanoparticles and suppresses V dissolution by preventing direct contact with aqueous electrolytes.The CNFs derived from the electrospun nanofibers provide a 3D network to increase the electronic conductivity of the LVP electrode,and the LVP@C-CNF hybrid film can be directly used as a freestanding cathode for zinc-ion batteries without adding conductive additives and binders.A mechanism for the formation of a uniform and continuous carbon coating has been proposed.This nanostructure,combined with the uniform and intact carbon coverage,significantly increases the electronic conductivity.This LVP@C-CNF freestanding electrode has an excellent rate capability(47.3%retention at 2 C)and cycling stability(61.2%retention after 100 cycles)within the voltage range 0.6 V to 1.95 V and is highly suitable for zinc-ion battery applications. 展开更多
关键词 Li3V2(PO4)3/C Electrospinning technology Carbon nanofiber films Freestanding cathode Zinc-ion batteries
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C3 glomerulopathy in transplant“like yet unlike native”:Pathophysiology,recent advances in therapeutics and evolving paradigms 认领 引用
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作者 Arun Chutani Sayna Norouzi Edgar V Lerma 《World Journal of Transplantation》 2026年第2期33-50,共18页
This review provides an in-depth examination of the recurrence and management of glomerular diseases after kidney transplantation,with particular emphasis on C3 glomerulopathy(C3G).Among post-transplant glomerular dis... This review provides an in-depth examination of the recurrence and management of glomerular diseases after kidney transplantation,with particular emphasis on C3 glomerulopathy(C3G).Among post-transplant glomerular diseases,C3G exhibits the highest recurrence rates,reported between 30%and 89%across studies.The review outlines the complex pathophysiology of C3G,driven by dysregulation of the complement system-whether from genetic variants,autoantibodies,monoclonal gammopathy,or other acquired factors.It highlights the diagnostic challenges posed by overlapping features with hemolytic uremic syndrome and membranoproliferative glomerulonephritis,as well as the difficulty in distinguishing complement overactivation from true regulatory failure.Key mechanisms of complement activation and the role of regulatory proteins are discussed,along with operative and clinical risk factors such as ischemia-reperfusion injury,delayed graft function,viral infections,and monoclonal gammopathy.The review describes the histopathologic spectrum of C3G in the allograft and underscores the importance of early protocol biopsies for timely detection.Management strategies include conservative measures,nonspecific immunosuppression,and emerging complement-targeted therapies.Recent Food and Drug Administration approvals of iptacopan and pegcetacoplan represents major advances.The review concludes by emphasizing personalized medicine,improved biomarkers,comprehensive genetic and autoantibody testing,and continued research to refine surveillance and treatment strategies for transplant recipients with C3G. 展开更多
关键词 C3 glomerulopathy Alternate pathway Complement Iptacopan Pegcetocoplan
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A(3,6)⁃c[Fe3(μ3⁃O)(acetate)2(carboxyl)4(pyridyl)2]cluster⁃based metal⁃organic framework with methyl⁃impendent gourd⁃shaped pores for natural gas purification 认领 引用
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作者 ZHANG Limin TANG Renqiang +3 位作者 ZHENG Yifan CHENG Hongtao WANG Qian BAI Junfeng 《无机化学学报》 SCIE CAS CSCD 北大核心 2026年第7期1412-1419,共8页
Novel adsorbents for efficient natural gas purification should strike a balance between high selective adsorption performance and moderate adsorption enthalpy.To develop such materials,herein,a novel(3,6)-c topologica... Novel adsorbents for efficient natural gas purification should strike a balance between high selective adsorption performance and moderate adsorption enthalpy.To develop such materials,herein,a novel(3,6)-c topological metal-organic framework(MOF)featuring terminal coordinated acetate was constructed from[Fe3(μ3-O)(acetate)2(carboxyl)4(pyridyl)2]cluster and 5-(pyridin-4-yl)isophthalic acid,yielding[FeⅢ2FeⅡ(μ3-O)(acetate)2(L)2(H2O)]·xGuest(designated as NJTU-Bai89;NJTU-Bai stands for Nanjing Tech University Bai´s group).The methyl group of acetate is impendent in the 1D pore channel,dividing it into the gourd-shaped one.Interestingly,NJTUBai89 exhibited high low-pressure C3H8uptake and moderate adsorption enthalpy,owing to effective synergy between a suitable pore size and accessible nonpolar pore surfaces.CCDC:2531702. 展开更多
关键词 metal-organic framework high low-pressure C3H8 uptake moderate adsorption enthalpy
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NS3 epitope-decorated nanoparticles produced in bacteria trigger potent T cell immunity against hepatitis C virus 认领 引用 被引量：1
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作者 Victor V.Kuprianov Lyudmila I.Nikolaeva +2 位作者 Maya D.Stuchinskaya Аnna A.Zykova Nikolai V.Ravin 《Journal of Biomedical Research》 CAS CSCD 2026年第2期185-195,共11页
The highly conserved human leukocyte antigen-A2(HLA-A2)-restricted epitope NS3-1073 represents a promising candidate for a therapeutic vaccine against hepatitis C virus(HCV).In this study,we engineered a set of fusion... The highly conserved human leukocyte antigen-A2(HLA-A2)-restricted epitope NS3-1073 represents a promising candidate for a therapeutic vaccine against hepatitis C virus(HCV).In this study,we engineered a set of fusion proteins based on the artificial self-assembling peptide(SAP),which were expressed in Escherichia coli and spontaneously self-assembled into nanosized particles displaying HCV epitopes,including NS3-1073.To enhance immunogenicity,we incorporated the T helper epitope PADRE into the construct.Alpha-helical linkers were introduced between SAP and the epitopes to facilitate proper protein folding.Notably,a helical linker with a high supercoiling propensity enabled soluble expression of the fusion protein containing both the NS3-1073 and PADRE epitopes,allowing purification of the in vivo-formed nanoparticles by metal affinity chromatography.Human dendritic cells derived from peripheral blood monocytes showed robust activation in response to the fusion proteins and preferentially stimulated T lymphocytes toward a Th1-biased immune response.In mice,immunization with nanoparticles carrying NS3-1073 induced splenocyte proliferation in response to in vitro stimulation with a mixture of NS3 peptides.These results demonstrate that recombinant nanoparticle-based carriers presenting the NS3-1073 epitope can be produced in bacterial systems and hold strong potential as a foundation for a therapeutic HCV vaccine. 展开更多
关键词 hepatitis C virus NS3 epitope nanoparticle self-assembling peptide vaccine
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糖尿病足溃疡患者创缘组织固有淋巴细胞3、VDR、PPARγ、VEGF-C表达与TTBT联合多口引流清创治疗预后的关系研究 认领 引用
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作者 罗燕宁 洪建仁 《中国美容整形外科杂志》 CAS 2026年第4期215-219,共5页
目的探究糖尿病足溃疡(diabetic foot ulcer,DFU)患者创缘组织固有淋巴细胞3(innate lymphocyte 3,ILC3)、维生素D受体(vitamin D receptor,VDR)、过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)... 目的探究糖尿病足溃疡(diabetic foot ulcer,DFU)患者创缘组织固有淋巴细胞3(innate lymphocyte 3,ILC3)、维生素D受体(vitamin D receptor,VDR)、过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)和血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)的表达与胫骨横向骨搬移术(transverse tibial bone transport,TTBT)联合多口引流清创治疗预后的关系。方法回顾性分析自2022年1月至2024年7月,黄石市中心医院手足显微外科采用TTBT联合多口引流清创治疗169例DFU患者的临床资料。治疗6个月后评估患者预后情况,并将患者分为预后不良组(n=52)与预后良好组(n=117),比较两组患者的一般资料及创缘组织ILC3表达情况,检测并比较创缘组织VDR、PPARγ和VEGF-C的mRNA及蛋白表达水平。绘制ROC曲线分析创缘组织ILC3、VDR、PPARγ、VEGF-C mRNA及蛋白表达水平与DFU患者接受TTBT联合多口引流清创治疗后预后的价值。结果预后良好组患者创缘组织ILC3水平、VDR mRNA、PPARγmRNA、VEGF-C mRNA、VDR蛋白、PPARγ蛋白、VEGF-C蛋白水平显著高于预后不良组(P<0.05);创缘组织ILC3、VDR mRNA、PPARγmRNA、VEGF-C mRNA、VDR蛋白、PPARγ蛋白、VEGF-C蛋白预测DFU患者预后的AUC分别为0.837、0.659、0.833、0.672、0.758、0.799、0.811,敏感度分别为86.54%、78.85%、92.31%、75.00%、94.23%、86.54%、75.00%,特异度分别为79.02%、51.28%、64.96%、57.26%、49.57%、59.83%、78.63%。结论DFU患者创缘组织中ILC3、VDR、PPARγ和VEGF-C mRNA及蛋白表达水平与TTBT联合多口引流清创治疗的良好预后密切相关,可为临床早期干预和预后评估提供参考。 展开更多
关键词 糖尿病足溃疡 固有淋巴细胞3 胫骨横向骨搬移术 多口引流清创 术后康复 维生素D受体 过氧化物酶体增殖物激活受体γ 血管内皮生长因子C
天麻钩藤饮通过调节TNF-α/STAT3/α1ACT信号通路抑制A1型星型胶质细胞激活减轻血管性痴呆模型大鼠神经元损伤作用机制 认领 引用 被引量：2
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作者 王小燕 赵敏 +4 位作者 田丰 萧闵 屈楠 刘福贵 刘迟晓 《中国实验方剂学杂志》 CAS CSCD 北大核心 2026年第7期56-65,共10页
目的:探究天麻钩藤饮对血管性痴呆模型大鼠肿瘤坏死因子-α(TNF-α)/信号转导与转录激活因子3(STAT3)/α1抗胰蛋白酶C末端尾片段(α1ACT)信号通路及A1星型胶质细胞的影响。方法:将72只雄性SD大鼠随机分为假手术组,模型组,天麻钩藤饮高... 目的:探究天麻钩藤饮对血管性痴呆模型大鼠肿瘤坏死因子-α(TNF-α)/信号转导与转录激活因子3(STAT3)/α1抗胰蛋白酶C末端尾片段(α1ACT)信号通路及A1星型胶质细胞的影响。方法:将72只雄性SD大鼠随机分为假手术组,模型组,天麻钩藤饮高、中、低剂量组(5.13、10.26、20.52 g·kg-1)及尼莫地平西药组(8.1 mg·kg-1),每组12只。采用永久性双侧颈总动脉闭塞法造模后干预4周。通过新物体识别实验评估学习记忆能力;强迫游泳实验观察行为症状;酶联免疫吸附测定法检测海马组织白细胞介素-6(IL-6)、CC趋化因子配体2(CCL2)水平;尼氏染色观察海马神经元形态;原位末端标记法(TUNEL)染色检测细胞凋亡;免疫组化检测脑源性神经营养因子(BDNF)、胶质纤维酸性蛋白(GFAP)、髓鞘碱性蛋白(MBP)阳性表达;蛋白免疫印迹法(Western blot)测海马组织TNF-α、TNF受体1(TNFR1)、磷酸化(p)-STAT3、α1ACT、IL-6、补体C3、BDNF、S100钙结合蛋白A10(S100A10)、GFAP蛋白表达。结果:与假手术组比较,模型组大鼠新物体相对识别指数显著降低(P<0.01),被动漂浮时间延长、次数显著增多(P<0.01);海马组织IL-6、CCL2表达显著升高(P<0.01),尼氏染色显示神经元数量减少、尼氏小体丢失(P<0.01),MBP阳性表达显著降低(P<0.01),细胞凋亡增多(P<0.01),BDNF阳性表达显著减少(P<0.05),GFAP阳性表达显著升高(P<0.01),TNF-α、TNFR1、p-STAT3、α1ACT、IL-6、补体C3蛋白表达显著升高(P<0.01),BDNF、S100A10显著降低(P<0.01)。与模型组比较,天麻钩藤饮各剂量组新物体相对识别指数明显升高(P<0.05,P<0.01),被动漂浮时间缩短、次数减少(P<0.01),IL-6、CCL2表达显著降低(P<0.05,P<0.01),神经元数量明显增加(P<0.05,P<0.01),MBP阳性表达显著增加(P<0.01),细胞凋亡显著减少(P<0.01),BDNF阳性表达明显增加(P<0.05),GFAP阳性表达显著降低(P<0.01),TNF-α、TNFR1、p-STAT3、α1ACT、IL-6、补体C3蛋白表达降低(P<0.05,P<0.01),BDNF、S100A10蛋白表达显著升高(P<0.01)。结论:天麻钩藤饮治疗可以通过TNF-α/STAT3/α1ACT信号通路抑制血管性痴呆大鼠A1型星型胶质细胞激活,减轻神经元凋亡,提高学习记忆能力。 展开更多
关键词 天麻钩藤饮 血管性痴呆 星型胶质细胞 肿瘤坏死因子-α(TNF-α)/信号转导与转录激活因子3(STAT3)/α1抗胰蛋白酶C末端尾片段(α1ACT)信号通路
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circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose-derived stem cells via the hsa-miR-647/SOX9 pathway 认领 引用
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作者 Dabiao Hou Huajun Wang +3 位作者 Hao Guo Dongbin Luo Xiaofei Zheng Simin Luo 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第12期2209-2221,共13页
Background:Human adipose-derived stem cells(hADSCs)are seed cells with application prospects in cartilage repair.However,the mechanism of hADSC chondrogenic differentiation is still unclear.This study identifies a nov... Background:Human adipose-derived stem cells(hADSCs)are seed cells with application prospects in cartilage repair.However,the mechanism of hADSC chondrogenic differentiation is still unclear.This study identifies a novel circRNA,circNR3C2,which is significantly upregulated during the chondrogenic differentiation of hADSCs.Methods:To analyze their role in hADSC chondrogenic differentiation,hADSCs were separated and identified by flow cytometry.Thereafter,we conducted Alcian Blue staining to assess chondrogenic differentiation levels.Additionally,RT-qPCR was carried out to detect levels of the cartilage-related genes COL2,Aggrecan and SOX9.Moreover,overlapping target SOX9 and circNR3C2 miRNAs were detected by bioinformatics and luciferase analyses.Finally,the role of circNR3C2 was confirmed in vivo using animal models.Results:We confirmed that the cell surface receptors CD44,CD90 and CD105 were positively expressed on hADSCs,and their cartilage differentiation levels dramatically increased after 2 weeks.Expression of the cartilage-related genes COL2 and Aggrecan and circNR3C2 also markedly increased.CircNR3C2 overexpression enhanced cartilage differentiation of hADSCs,while up-regulating COL2,SOX9 and Aggrecan.Bioinformatics analysis identified hsa-miR-647 as the target miRNA of circ-NR3C2 and SOX9.Hsa-miR-647 overexpression in hADSCs can antagonize the effect of circNR3C2 on chondrogenic differentiation,and reverse its effect on regulating the expression of COL2,Aggrecan,and SOX9.We also showed that hADSCs overexpressing circNR3C2 promote cartilage repair in vivo.Conclusions:We show that circNR3C2 modulates SOX9 expression to promote hsamiR-647-mediated hADSC chondrogenic differentiation;targeting circNR3C2 may help to develop new treatments to manage cartilage-related disorders. 展开更多
关键词 cartilage repair chondrocyte differentiation circNR3c2 hADSCs hsa-miR-647 SOX9
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血清补体C1q、C3a、C4水平与2型糖尿病微血管病变的关系 认领 引用 被引量：1
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作者 郝建波 胡春雨 王理鑫 《分子诊断与治疗杂志》 2026年第1期63-66,共4页
目的探讨血清补体C1q、C3a、C4水平与2型糖尿病(T2DM)微血管病变(DMC)的关系。方法选取2023年1月至2025年1月郑州大学第二附属医院收治的单纯T2DM患者50例作为T2DM组,选取50例T2DM合并DMC患者作为DMC组,另选择同期50名健康体检者作为对... 目的探讨血清补体C1q、C3a、C4水平与2型糖尿病(T2DM)微血管病变(DMC)的关系。方法选取2023年1月至2025年1月郑州大学第二附属医院收治的单纯T2DM患者50例作为T2DM组,选取50例T2DM合并DMC患者作为DMC组,另选择同期50名健康体检者作为对照组,比较三组血清补体C1q、C3a、C4水平;采用Pearson相关性分析补体C1q、C3a、C4与DMC患者血糖、血脂指标的相关性;采用二元Logistic回归分析T2DM患者发生DMC的危险因素;采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析血清补体C1q、C3a、C4对T2DM患者DMC的诊断价值。结果血清补体C1q、C3a、C4水平比较:DMC组>T2DM组>对照组,差异有统计学意义(P<0.05)。DMC组与T2DM组体重指数(BMI)、病程、血糖指标空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂指标三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗指数(HOMA-IR)、血尿酸(UA)、肌酐(Scr)比较差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,T2DM发生DMC患者血清补体C1q、C3a、C4与FPG、HbA1c、TG、TC、LDL-C呈正相关性,与HDL-C呈负相关性(P<0.05)。二元Logistic回归分析结果显示,病程、FPG、HbA1c、C1q、C3a、C4为T2DM患者发生DMC的影响因素(P<0.05)。ROC曲线结果显示,C1q诊断T2DM患者发生DMC的截断值为293.65 mg/L,AUC为0.831(95%CI 0.751~0.911),灵敏度为0.841,特异度为0.800。C3a诊断T2DM患者发生DMC的截断值为394.22 mg/L,AUC为0.832(95%CI 0.748~0.916),灵敏度为0.837,特异度为0.802。C4诊断T2DM患者发生DMC的截断值为330.39 mg/L,AUC为0.824(95%CI 0.736~0.912),灵敏度为0.820,特异度为0.773。结论血清补体活化在T2DM发生DMC的病理过程中存在重要作用,血清补体C1q、C3a、C4水平升高可增加T2DM发生DMC的风险,三指标可作为T2DM发生DMC的可靠预测指标。 展开更多
关键词 2型糖尿病 糖尿病微血管病变 补体因子C1q 补体因子C3a 补体因子C4
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AKR1C3通过PD1/PD-L1信号通路对乳腺癌细胞恶性生物学行为的干预作用 认领 引用 被引量：1
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作者 宋晶晶 熊伟 +2 位作者 姚淑辉 刘爽 张静 《昆明医科大学学报》 CAS 2026年第1期31-38,共8页
目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)... 目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)通路的影响。方法把MCF-7人乳腺癌细胞中NC组和AKR1C3组分别转染空质粒和AKR1C3质粒,采用MTT法检测转染后24 h、48 h、72 h细胞活力;采用流式细胞技术测定各组细胞的存活率以及早期、晚期凋亡比例;通过Transwell实验对各组细胞的迁移和侵袭能力进行检测;通过Western blot检测各组细胞PD-1、PD-L1、蛋白激酶B(protein kinase b,AKT)蛋白表达水平。使用C57BL/6小鼠构建荷瘤模型,将采用人乳腺癌MCF-7细胞转染NC质粒和AKR1C3质粒进行细胞荷瘤,每3 d测量瘤体积,持续21 d,绘制两组小鼠肿瘤生长曲线,并于实验终点测量肿瘤质量。结果相较于NC组,AKR1C3组细胞活力降低(P<0.05),并且具有时间依赖效应(P<0.05),迁移和侵袭能力降低(P<0.05),早期凋亡和晚期凋亡比例升高(P<0.05),PD-1、PD-L1、AKT蛋白表达水平降低(P<0.05)。动物实验表明,AKR1C3组小鼠肿瘤体积降低,肿瘤质量下降(P<0.05)。结论AKR1C3可以抑制人乳腺癌细胞恶性生物学行为,抑制PD-1/PDL1信号通路蛋白表达。 展开更多
关键词 AKR1C3 人乳腺癌 凋亡 迁移 PD-1/PD-L1通路 侵袭 AKT PPR5
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血清PCT、pentraxin-3及Cys-C水平与复发性糖尿病足溃疡的关系 认领 引用 被引量：1
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作者 王崇贤 李俊 《河南医学研究》 CAS 2026年第8期1391-1395,共5页
目的 分析降钙素原(PCT)、pentraxin-3及胱抑素C(Cys-C)与复发性糖尿病足溃疡(DFUs)的关系。方法 选取2020年2月至2024年2月郑州大学第二附属医院接诊的DFUs患者207例,随访4个月统计患者复发情况,将复发患者纳入复发组,未复发患者纳入... 目的 分析降钙素原(PCT)、pentraxin-3及胱抑素C(Cys-C)与复发性糖尿病足溃疡(DFUs)的关系。方法 选取2020年2月至2024年2月郑州大学第二附属医院接诊的DFUs患者207例,随访4个月统计患者复发情况,将复发患者纳入复发组,未复发患者纳入未复发组,并根据病情严重程度进行Wagner分级。比较复发组、未复发组血清PCT、pentraxin-3及Cys-C水平;经logistic回归模型分析DFUs复发的影响因素;绘制受试者工作特征(ROC)曲线分析血清PCT、pentraxin-3、Cys-C单独及联合预测DFUs复发的临床价值,并经Pairwise算法检验;比较不同Wagner分级复发性DFUs患者血清PCT、pentraxin-3、Cys-C水平。结果 DFUs患者复发率为36.60%;logistic回归模型分析显示,2型糖尿病(T2DM)病程、糖化血红蛋白(HbA1c)、病变位置为脚底、PCT、pentraxin-3、Cys-C是DFUs复发的危险因素(P<0.05),糖尿病足部自我管理行为量表(DFSBS)评分是其保护因素(P<0.05);Pairwise算法检验显示,与PCT、pentraxin-3、Cys-C单独检验比较,三者联合检验的曲线下面积(AUC)均升高(Z=4.126,P<0.001;Z=3.931,P=0.001;Z=4.491,P<0.001);不同Wagner分级复发性DFUs患者血清PCT、pentraxin-3、Cys-C水平比较,差异有统计学意义(P<0.05);与1级比较,2~3级、4~5级患者血清PCT、pentraxin-3、Cys-C水平均升高(P<0.05);与2~3级比较,4~5级患者血清PCT、pentraxin-3、Cys-C水平均升高(P<0.05)。结论 PCT、pentraxin-3、Cys-C是DFUs复发的危险因素,且与DFUs的严重程度有关。 展开更多
关键词 糖尿病足溃疡 复发 降钙素原 pentraxin-3 胱抑素C
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χ-Fe5C2与θ-Fe3C在逆水煤气变换中的结构演变规律 认领 引用
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作者 孙泽平 梁瑞康 +4 位作者 魏子都 张超 相宏伟 武建兵 刘兴武 《燃料化学学报（中英文）》 EI CAS CSCD 北大核心 2026年第5期153-163,共11页
铁基催化剂在CO2/H2气氛中常经历动态的碳化与氧化相变,其活性相识别及稳定性调控仍是影响其工业应用的关键问题。本工作采用气固渗碳法分别制备高纯度的单相χ-Fe5C2(Hägg碳化物)与θ-Fe3C(cementite),通过XRD、... 铁基催化剂在CO2/H2气氛中常经历动态的碳化与氧化相变,其活性相识别及稳定性调控仍是影响其工业应用的关键问题。本工作采用气固渗碳法分别制备高纯度的单相χ-Fe5C2(Hägg碳化物)与θ-Fe3C(cementite),通过XRD、穆斯堡尔谱(MES)系统确认其结构纯度。利用固定床反应(H2/CO2=1,0.1 MPa,270-420℃)、脉冲实验(270℃)及原位XRD(10%CO2/He,340℃)等手段,深入探讨两者在逆水煤气变换(RWGS)反应中的活性表现与结构演变路径。结果表明,χ-Fe5C2具有更高的RWGS活性,但在反应过程中更易氧化;θ-Fe3C则表现出较强的抗氧化稳定性,但其RWGS活性较低。在含H2的RWGS工况下,θ-Fe3C可部分转化为χ-Fe5C2;而10%CO2气氛下,两者均直接氧化为Fe3O4,未观察到碳化铁相间转变。上述结果揭示了χ-Fe5C2与θ-Fe3C在不同气氛下的演变机制差异,为铁基费托及RWGS催化剂的相结构调控与运行稳定性优化提供了实验依据。 展开更多
关键词 χ-Fe5C2 θ-Fe3C RWGS反应 原位XRD
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