当前,电力通信网存在大量恒定比特率(constant bit rate,CBR)业务,在同步数字体系(synchronous digital hierarchy,SDH)/多业务传送平台(multi-service transfer platform,MSTP)等传统网络设备面临退网、承载网络技术急需升级演进的背景...当前,电力通信网存在大量恒定比特率(constant bit rate,CBR)业务,在同步数字体系(synchronous digital hierarchy,SDH)/多业务传送平台(multi-service transfer platform,MSTP)等传统网络设备面临退网、承载网络技术急需升级演进的背景下,需要解决新技术路线下电力CBR业务的承载和管控问题。文章介绍了基于城域传送网(metro transport network,MTN)小颗粒通道技术的CBR业务承载转发面技术方案,在此基础上,提出面向电力CBR业务承载的新型“集中式SDN+分布式管控”模型架构,针对电力CBR业务的高时延稳定性需求,对CBR业务处理及通道路径分配机制进行优化,基于此优化方法进行了通道路径最优规划的仿真设计,结果表明提出的管控模型架构和方法能优化CBR业务的处理和路径计算效果,具备较好的扩展性。展开更多
Carbonyl reductase 1(CBR1),a member of the short-chain dehydrogenaseeductase(SDR)superfamily,is implicated in tumor progression and treatment resistance.However,its role in non-small cell lung cancer(NSCLC)remains unc...Carbonyl reductase 1(CBR1),a member of the short-chain dehydrogenaseeductase(SDR)superfamily,is implicated in tumor progression and treatment resistance.However,its role in non-small cell lung cancer(NSCLC)remains unclear.This study examined CBR1 expression in NSCLC tissues and cell lines,using gene interference and pharmacological inhibition to assess its impact on stemness,chemosensitivity,and quiescence,and to explore underlying mechanisms.Our findings indicate that CBR1 expression is elevated in NSCLC tissues and cell lines,and further increases in the presence of cisplatin(CDDP).Gene interference reducing CBR1 expression significantly decreased the percentage of cluster of differentiation 133(CD133)-positive cells and the expression of octamer-binding transcription factor 4(OCT4)and SRY(sex determining region Y)-box 2(SOX2),while enhancing CDDP chemosensitivity.The CBR1-specific inhibitor hydroxy-PP-Me(PP-Me)markedly increased CDDP cytotoxicity and reduced stemness.Additionally,CBR1 inhibition via short hairpin RNA(shRNA)CBR1(sh-CBR1)or PP-Me disrupted NSCLC cell quiescence,as shown by a decrease in G0 phase cells and p27 expression,alongside an increase in cyclin D1 and phospho-retinoblastoma(pRb)expression.Furthermore,SET domain-containing protein 4(SETD4),which mediates stemness,chemosensitivity,and quiescence in NSCLC cells,was downregulated by sh-CBR1 or PP-Me treatment.The overexpression of SETD4 counteracted the enhanced chemosensitivity resulting from CBR1 inhibition.In A549 xenografts,combined PP-Me and CDDP therapy significantly inhibited tumor growth compared to either treatment alone.In conclusion,CBR1 inhibition enhances CDDP chemosensitivity by suppressing stemness and quiescence in NSCLC.展开更多
为科学预测洪涝灾害下应急物资的航空器运输架次,运用文本挖掘和自然语言处理(natural language processing,NLP)技术,提取了2018—2023年间国内权威新闻媒体的洪涝灾害报道数据,构建了灾害案例库。结合K-最近邻(k-nearest neighbor,KNN...为科学预测洪涝灾害下应急物资的航空器运输架次,运用文本挖掘和自然语言处理(natural language processing,NLP)技术,提取了2018—2023年间国内权威新闻媒体的洪涝灾害报道数据,构建了灾害案例库。结合K-最近邻(k-nearest neighbor,KNN)算法和马氏距离理论设计了洪涝灾害案例推理(case-based reasoning,CBR)的相似度匹配算法,以河南省“7·20”暴雨下郑州市巩义米河镇为目标案例,完成了目标案例与历史案例的多尺度匹配。引入库存管理模型,以伤亡人数预测为依托,量化了目标案例的应急物资种类与需求。最后,结合直升机与固定翼等不同类型的救援航空器适用条件和应急物资空地运输比例,预测了航空器的需求架次。结果表明,目标案例与2021年四川省达州市渠县洪涝灾害的匹配度最高,结合库存管理模型和航空器载重,可得到不同物资需求下的航空器运输架次。研究结论为非常规突发事件下应急物资的航空运输决策提供方法支撑。展开更多
The soil packing,influenced by variations in grain size and the gradation pattern within the soil matrix,plays a crucial role in constituting the mechanical properties of sandy soils.However,previous modeling approach...The soil packing,influenced by variations in grain size and the gradation pattern within the soil matrix,plays a crucial role in constituting the mechanical properties of sandy soils.However,previous modeling approaches have overlooked incorporating the full range of representative parameters to accurately predict the soaked California bearing ratio(CBRs)of sandy soils by precisely articulating soil packing in the modeling framework.This study presents an innovative artificial intelligence(AI)-based approach for modeling the CBRsof sandy soils,considering grain size variability meticulously.By synthesizing extensive data from multiple sources,i.e.extensive tailored testing program undertaking multiple tests and extant literature,various modeling techniques including genetic expression programming(GEP),multi-expression programming(MEP),support vector machine(SVM),and multi-linear regression(MLR)are utilized to develop models.The research explores two modeling strategies,namely simplified and composite,with the former incorporating only sieve analysis test parameters,while the latter includes compaction test parameters alongside sieve analysis data.The models'performance is assessed using statistical key performance indicators(KPIs).Results indicate that genetic AI-based algorithms,particularly GEP,outperform SVM and conventional regression techniques,effectively capturing complex relationships between input parameters and CBRs.Additionally,the study reveals insights into model performance concerning the number of input parameters,with GEP consistently outperforming other models.External validation and Taylor diagram analysis demonstrate the GEP models'superiority over existing literature models on an independent dataset from the literature.Parametric and sensitivity analyses highlight the intricate relationships between grain sizes and CBRs,further emphasizing GEP's efficacy in modeling such complexities.This study contributes to enhancing CBRsmodeling accuracy for sandy soils,crucial for pertinent infrastructure design and construction rapidly and cost-effectively.展开更多
摘要当前,电力通信网存在大量恒定比特率(constant bit rate,CBR)业务,在同步数字体系(synchronous digital hierarchy,SDH)/多业务传送平台(multi-service transfer platform,MSTP)等传统网络设备面临退网、承载网络技术急需升级演进的背景下,需要解决新技术路线下电力CBR业务的承载和管控问题。文章介绍了基于城域传送网(metro transport network,MTN)小颗粒通道技术的CBR业务承载转发面技术方案,在此基础上,提出面向电力CBR业务承载的新型“集中式SDN+分布式管控”模型架构,针对电力CBR业务的高时延稳定性需求,对CBR业务处理及通道路径分配机制进行优化,基于此优化方法进行了通道路径最优规划的仿真设计,结果表明提出的管控模型架构和方法能优化CBR业务的处理和路径计算效果,具备较好的扩展性。
基金supported by the National Natural Science Foundation of China(No.82170054)the Natural Science Foundation of Zhejiang Province(No.Y21H010014),China。
摘要Carbonyl reductase 1(CBR1),a member of the short-chain dehydrogenaseeductase(SDR)superfamily,is implicated in tumor progression and treatment resistance.However,its role in non-small cell lung cancer(NSCLC)remains unclear.This study examined CBR1 expression in NSCLC tissues and cell lines,using gene interference and pharmacological inhibition to assess its impact on stemness,chemosensitivity,and quiescence,and to explore underlying mechanisms.Our findings indicate that CBR1 expression is elevated in NSCLC tissues and cell lines,and further increases in the presence of cisplatin(CDDP).Gene interference reducing CBR1 expression significantly decreased the percentage of cluster of differentiation 133(CD133)-positive cells and the expression of octamer-binding transcription factor 4(OCT4)and SRY(sex determining region Y)-box 2(SOX2),while enhancing CDDP chemosensitivity.The CBR1-specific inhibitor hydroxy-PP-Me(PP-Me)markedly increased CDDP cytotoxicity and reduced stemness.Additionally,CBR1 inhibition via short hairpin RNA(shRNA)CBR1(sh-CBR1)or PP-Me disrupted NSCLC cell quiescence,as shown by a decrease in G0 phase cells and p27 expression,alongside an increase in cyclin D1 and phospho-retinoblastoma(pRb)expression.Furthermore,SET domain-containing protein 4(SETD4),which mediates stemness,chemosensitivity,and quiescence in NSCLC cells,was downregulated by sh-CBR1 or PP-Me treatment.The overexpression of SETD4 counteracted the enhanced chemosensitivity resulting from CBR1 inhibition.In A549 xenografts,combined PP-Me and CDDP therapy significantly inhibited tumor growth compared to either treatment alone.In conclusion,CBR1 inhibition enhances CDDP chemosensitivity by suppressing stemness and quiescence in NSCLC.
摘要为科学预测洪涝灾害下应急物资的航空器运输架次,运用文本挖掘和自然语言处理(natural language processing,NLP)技术,提取了2018—2023年间国内权威新闻媒体的洪涝灾害报道数据,构建了灾害案例库。结合K-最近邻(k-nearest neighbor,KNN)算法和马氏距离理论设计了洪涝灾害案例推理(case-based reasoning,CBR)的相似度匹配算法,以河南省“7·20”暴雨下郑州市巩义米河镇为目标案例,完成了目标案例与历史案例的多尺度匹配。引入库存管理模型,以伤亡人数预测为依托,量化了目标案例的应急物资种类与需求。最后,结合直升机与固定翼等不同类型的救援航空器适用条件和应急物资空地运输比例,预测了航空器的需求架次。结果表明,目标案例与2021年四川省达州市渠县洪涝灾害的匹配度最高,结合库存管理模型和航空器载重,可得到不同物资需求下的航空器运输架次。研究结论为非常规突发事件下应急物资的航空运输决策提供方法支撑。
摘要The soil packing,influenced by variations in grain size and the gradation pattern within the soil matrix,plays a crucial role in constituting the mechanical properties of sandy soils.However,previous modeling approaches have overlooked incorporating the full range of representative parameters to accurately predict the soaked California bearing ratio(CBRs)of sandy soils by precisely articulating soil packing in the modeling framework.This study presents an innovative artificial intelligence(AI)-based approach for modeling the CBRsof sandy soils,considering grain size variability meticulously.By synthesizing extensive data from multiple sources,i.e.extensive tailored testing program undertaking multiple tests and extant literature,various modeling techniques including genetic expression programming(GEP),multi-expression programming(MEP),support vector machine(SVM),and multi-linear regression(MLR)are utilized to develop models.The research explores two modeling strategies,namely simplified and composite,with the former incorporating only sieve analysis test parameters,while the latter includes compaction test parameters alongside sieve analysis data.The models'performance is assessed using statistical key performance indicators(KPIs).Results indicate that genetic AI-based algorithms,particularly GEP,outperform SVM and conventional regression techniques,effectively capturing complex relationships between input parameters and CBRs.Additionally,the study reveals insights into model performance concerning the number of input parameters,with GEP consistently outperforming other models.External validation and Taylor diagram analysis demonstrate the GEP models'superiority over existing literature models on an independent dataset from the literature.Parametric and sensitivity analyses highlight the intricate relationships between grain sizes and CBRs,further emphasizing GEP's efficacy in modeling such complexities.This study contributes to enhancing CBRsmodeling accuracy for sandy soils,crucial for pertinent infrastructure design and construction rapidly and cost-effectively.