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Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus 认领 引用 被引量：1
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作者 Ashwin Kumar Shukla Komal Awasthi +1 位作者 Kauser Usman Monisha Banerjee 《World Journal of Diabetes》 SCIE 2024年第4期606-622,共17页
Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 virus.It has affected over 768 million people worldwide,result... Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 virus.It has affected over 768 million people worldwide,resulting in approx-imately 6900000 deaths.High-risk groups,identified by the Centers for Disease Control and Prevention,include individuals with conditions like type 2 diabetes mellitus(T2DM),obesity,chronic lung disease,serious heart conditions,and chronic kidney disease.Research indicates that those with T2DM face a hei-ghtened susceptibility to COVID-19 and increased mortality compared to non-diabetic individuals.Examining the renin-angiotensin system(RAS),a vital regulator of blood pressure and pulmonary stability,reveals the significance of the angiotensin-converting enzyme(ACE)and ACE2 enzymes.ACE converts angiotensin-I to the vasoconstrictor angiotensin-II,while ACE2 counters this by converting angiotensin-II to angiotensin 1-7,a vasodilator.Reduced ACE2 exp-ression,common in diabetes,intensifies RAS activity,contributing to conditions like inflammation and fibrosis.Although ACE inhibitors and angiotensin receptor blockers can be therapeutically beneficial by increasing ACE2 levels,concerns arise regarding the potential elevation of ACE2 receptors on cell membranes,potentially facilitating COVID-19 entry.This review explored the role of the RAS/ACE2 mechanism in amplifying severe acute respiratory syndrome cor-onavirus 2 infection and associated complications in T2DM.Potential treatment strategies,including recombinant human ACE2 therapy,broad-spectrum antiviral drugs,and epigenetic signature detection,are discussed as promising avenues in the battle against this pandemic. 展开更多
关键词 Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-II receptor blockers Complex diseases COVID-19 Type 2 diabetes
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The Relationship between ABO Blood Group Type and the COVID-19 Susceptibility in Qatif Central Hospital, Eastern Province, Saudi Arabia: A Retrospective Cohort Study 认领 引用 被引量：1
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作者 Ghada Ali Aljanobi Alya Hassan Alhajjaj +1 位作者 Fatimah Lateef Alkhabbaz Jumana Mansour Al-Jishi 《Open Journal of Internal Medicine》 2020年第2期232-238,共7页
Introduction: It has been found that the viral infection is linked to the ABO blood group. Limited studies investigated the relationship of the ABO blood group and susceptibility to COVID-19 infection. Objective: To i... Introduction: It has been found that the viral infection is linked to the ABO blood group. Limited studies investigated the relationship of the ABO blood group and susceptibility to COVID-19 infection. Objective: To investigate the association between the ABO blood group and the COVID-19 susceptibility. Material & Methods: The study is a retrospective cohort study. It included all hospitalized confirmed COVID-19 patients in Qatif central hospital, Eastern province, Saudi Arabia. We included both genders and people who are older than 14 years of age. The study was conducted in the period between 15th March, and 15th April, 2020. Results: Our sample consists of 72 patients;we found a percentage distribution of 23.62%, 33.33%, 9.72%, and 33.33% for blood groups A, B, AB and O, respectively. Our results showed significantly increased risk for AB blood groups (P Conclusion: Our findings suggest that among confirmed COVID-19 patients, patients with AB blood group have higher susceptibility while patients with O blood group have lower susceptibility to COVID-19 infection. Our study has limitations and further studies are needed. 展开更多
关键词 ABO Group Saudi Qatif COVID-19
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The association between TMPRSS2 gene rs2070788 and rs12329760 variants and COVID-19 susceptibility and severity:A study from Jordan 认领 引用
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作者 Sara S.H.Abu Zaid Omar F.Khabour Sawsan Abuhammad 《Journal of Biosafety and Biosecurity》 2025年第3期107-113,共7页
Symptoms of coronavirus disease of 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),range from asymptomatic to life-threatening,affecting the respiratory system and many other organ... Symptoms of coronavirus disease of 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),range from asymptomatic to life-threatening,affecting the respiratory system and many other organs,and involved in SARS-CoV-2 pathogenesis,particularly its viral entry,is the enzyme transmembrane protease serine 2(TMPRSS2).In response,in this study,polymorphisms in the TMPRSS2 gene(rs2070788 and rs12329760)were examined for their association with COVID-19 susceptibility and severity in Jordanians.The study participants(n=861)included 427 individuals who had never contracted COVID-19(control group)and 434 who had experienced the disease(case group).The case group was subsequently divided into two subgroups:severe(n=166)and non-severe(n=268)COVID-19.The results show that rs2070788 is associated with disease susceptibility in all inheritance models(P<0.05),as well as an association between rs12329760 and COVID-19 disease severity in both the dominant and over-dominant models(P<0.05).Further,a higher body mass index(BMI)and older age were associated with disease severity(p<0.05),though females were less likely to develop severe COVID-19 and to be hospitalized.In conclusion,polymorphisms in the TMPRSS2 gene may be considered a potential predictor of COVID-19 outcomes in the Jordanian population.The study findings could be used to manage similar viral infections in Jordan in the future. 展开更多
关键词 COVID-19 TMPRSS2 SARS-CoV-2 Polymorphism Jordan Disease outcomes
Effectiveness of Xuanbai Shengmai Decoction,a compound Chinese herbal medicine,on disease progress and viral RNA shedding in COVID-19 patients:A retrospective study of medical chart in China 认领 引用 被引量：1
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作者 Teng-wen Liu Shu-wen Zhang +15 位作者 Hui Jiang Si-wen Yang Yi-jia Guo Mao-yu Ding Xu-cheng Li Jia Xu Hai-tian Lu Hao-ran Ye Ya-hui Hu Rui Li Yi-ming Wei Mai-fen Song Shuo Wang Jun Zhang Quan-sheng Feng Xiao-long Xu 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期115-124,共10页
Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods... Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods:We collected demographic and clinical information of 212 COVID-19 cases from December2022 to January 2023,and divided these cases into two groups based on whether XB was used or not.Survival curves in the two groups were estimated by the Kaplan-Meier method.A smoothing approximation of time-to-event distributions was created based on a log-rank test and a restricted mean survival time model,and the Gaussian density estimation method.In addition,the effect of XB treatment on survival time was assessed using a series of Cox proportional hazards models.Results:Of all 212 COVID-19 cases,there were respectively 63 and 149 cases reported in XB group and non-XB group.Of those,128(60.4%)were male,with median age of 75.00 years,and 72.6%had one or more underlying medical conditions.The most common symptoms on admission were cough(64.6%),fever(39.6%),wheezing(27.8%)and sputum(13.2%).In addition,the gender,age group distribution,smoking,and drinking between two groups were of no significant difference(P>0.05).However,the clinical characteristics and CT findings in XB group were more serious than those in non-XB group.Nevertheless,the hazard of death in XB group was lower than that in non-XB group,especially on severe cases.Treatment with XB significantly protected against adverse outcomes,shorten the time of viral RNA shedding.Moreover,interventional therapy of XB within 1–2 days after hospital admission is confirmed with particularly effectiveness.Conclusion:Treatment of XB is effective for COVID-19 cases,particularly in reducing the mortality rate of severe cases,suggesting that XB may be used as an alternative treatment of SARS-COV-2 infection. 展开更多
关键词 COVID-19 Severe case Traditional Chinese medicine Retrospective study Mortality RNA shedding
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Changes in Bacterial Etiology and Antimicrobial Resistance of Lower Respiratory Tract Infections Following the COVID-19 Pandemic:A Five-Year Comparative Study in Central China 认领 引用 被引量：1
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作者 Sui Gao Cui Jian 《Current Medical Science》 SCIE CAS CSCD 2026年第1期256-263,共8页
Objective To investigate the impact of the coronavirus disease 2019(COVID-19)pandemic on the bacterial profile of lower respiratory tract infections(LRTIs)and the prevalence of major drug-resistant bacteria in Hubei P... Objective To investigate the impact of the coronavirus disease 2019(COVID-19)pandemic on the bacterial profile of lower respiratory tract infections(LRTIs)and the prevalence of major drug-resistant bacteria in Hubei Province,China,by comparing five-year periods before(2015-2019)and after(2020-2024)the pandemic.Methods A retrospective analysis was conducted on microbial culture and antimicrobial susceptibility test results from sputum and bronchoalveolar lavage fluid(BALF)samples obtained from patients with LRTIs.Pathogen distribution and the prevalence of key drug-resistant bacteria,including methicillin-resistant Staphylococcus aureus(MRSA),cefotaxime/ceftriaxone-resistant Enterobacterales,carbapenem-resistant Enterobacterales(CRE),carbapenem-resistant Pseudomonas aeruginosa(CRPAE),carbapenem-resistant Acinetobacter baumannii(CRABA),ampicillin-resistant Haemophilus influ-enzae(ARHI),and penicillin/erythromycin-resistant Streptococcus pneumoniae(PRSP/ERSP),were compared between the two periods.Results The overall number of bacterial isolates significantly increased during the post-pandemic period.Gram-negative bacteria remained dominant,although their relative composition shifted.The detection rates of common community-acquired pathogens(Haemophilus influenzae,Streptococcus pneumoniae)decreased sharply during the strict control phase(2020-2022)but rebounded from 2023 to 2024.The overall prevalence of most key drug-resistant bacteria followed a decreasing trend.Notably,the detection rates of MRSA and cefotaxime/ceftriaxone-resistant Enterobacterales decreased most mark-edly(≥15%).The prevalence of CRE and CRABA followed a"decrease-then-increase"trend,while carbapenem-resistant Klebsiella pneumoniae detection rates remained higher than the 2015 baseline,and carbapenem-resistant Escherichia coli prevalence was on par with the 2015 level in 2024.Although the detection rate of CRABA tended to decrease,it remained above 60%.In contrast,the detection rate of the ERSP was consistently high(≥90%),whereas that of the ARHI exhibited a continuous upward trend(increasing by more than 30%).Conclusion The COVID-19 pandemic significantly altered the bacterial ecology and resistance patterns of LRTIs.While stringent public health measures initially suppressed the transmission of some resistant pathogens,they may have facilitated the subsequent emergence and spread of more formidable drug-resistant bacteria.Continuous surveillance and reinforced infection control measures are crucial in the post-pandemic era. 展开更多
关键词 COVID-19 Lower respiratory tract infections Bacterial etiology Antimicrobial resistance Methicillinresistant Staphylococcus aureus(MRSA) Carbapenem-resistant Enterobacterales(CRE) Klebsiella pneumoniae Drug resistance surveillance Epidemiology China
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基于混合分解和Time2Vec-BiLSTM-SA模型的COVID-19疫情趋势预测 认领 引用
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作者 李玉洪 毕贵红 +3 位作者 孔凡文 童涛南 黎仕瑞 陈世语 《云南大学学报（自然科学版）》 CAS CSCD 北大核心 2026年第1期45-61,共17页
COVID-19疫情对国际公共卫生构成了巨大的挑战,准确的病例数预测对卫生资源的规划和疫情评估具有重要意义.COVID-19疫情是在疫情防控政策影响下,病毒、个体、环境与防控组织之间复杂交互作用所产生的宏观结果,疫情传播出现复杂的非线性... COVID-19疫情对国际公共卫生构成了巨大的挑战,准确的病例数预测对卫生资源的规划和疫情评估具有重要意义.COVID-19疫情是在疫情防控政策影响下,病毒、个体、环境与防控组织之间复杂交互作用所产生的宏观结果,疫情传播出现复杂的非线性动力学特性,疫情新发病例时间序列具有复杂的非线性非平稳特征.为提高对COVID-19大流行趋势的预测精度,提出一种结合变分模态分解(variational mode decomposition,VMD)和奇异谱分解(singular spectrum decomposition,SSD)混合,以及时间向量嵌入层(time to vector,Time2Vec)、双向长短期记忆模块(bidirectional long short-term memory,BiLSTM)和自注意力机制模块(self attention,SA)组合的三分支输入的Time2Vec-BiLSTM-SA综合集成结构预测方法.利用VMD和SSD方法对复杂的新发病例序列生成具有不同模态且复杂度低规律性强的多尺度分量,两种不同模态子分量组合为混合分量,实现不同模态多尺度分量的特征互补,丰富输入特征信息,为提取复杂非线性序列的不同侧面的特征信息提供基础.各分支均利用Time2Vec模块编码时间信息,捕获周期性、非周期性特征,BiLSTM模块捕捉序列双向长时依赖关系,SA模型加权重要特征并调整权重进行综合集成.提出的方法在美国加州8个县的县级数据以及印度和意大利两个国家级数据上进行了实验验证,并与多种数据处理方式、模型结构及使用相同数据集的其他文献方法进行了对比.结果表明,提出的方法在各项预测误差指标上均显著优于现有方法,证明了其在提高COVID-19疫情趋势预测精度方面的有效性,具备良好的普适性和泛化能力. 展开更多
关键词 COVID-19疫情 趋势预测 混合分解 时间向量嵌入层 深度学习模型
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Risk factors for thoracic-osteoporotic thoracic vertebral compression fractures during the normalized prevention and control period of COVID-19 认领 引用
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作者 Yi-Fan Li Chen-Qiong Wu +5 位作者 Yang Long Qi-Feng Yu Wei Xu Jian-Jie Zhao Xiang-Yang Zhang Zhi-Kun Li 《World Journal of Orthopedics》 2026年第2期56-67,共12页
BACKGROUND Some scholars believe that there is a certain correlation between coronavirus disease 2019(COVID-19)infection and the occurrence of osteoporotic vertebral compression fractures(OVCF),but no relevant domesti... BACKGROUND Some scholars believe that there is a certain correlation between coronavirus disease 2019(COVID-19)infection and the occurrence of osteoporotic vertebral compression fractures(OVCF),but no relevant domestic research reports have been published yet.This study retrospectively analyzed the clinical data of patients admitted for OVCF and treated with percutaneous vertebroplasty during the normalized prevention and control period of COVID-19 in Shanghai(after June 1,2022),aiming to explore the individual differences of OVCF patients during this special period and analyze the risk factors for OVCF.AIM To explore risk factors for senile OVCF during COVID-19 normalization.METHODS Retrospective analysis of 230 OVCF patients(June 2022 to June 2023,percutaneous vertebroplasty,observation group)and 236 controls(June 2020 to June 2021,OVCF surgery).Observation group was split into nucleic acidpositive(n=85)and negative(n=145)subgroups.Fracture location/cause,visual analogue scale,activity scores were compared;risk factors identified.RESULTS Observation group had 42.2%thoracic fractures and 38.2%cough-induced fractures(both higher than controls,P0.05).Nucleic acid results,fracture cause/location correlated(P<0.05;cause-location r=0.827).Logistic regression showed fracture cause,nucleic acid result,body mass index,bone mineral density as high-risk factors.CONCLUSION During COVID-19 normalization,cough is the top OVCF cause;thoracic fractures rise.The four factors above are independent risks.For elderly COVID-positive patients with recurrent cough,lung disease treatment,antiosteoporosis therapy,and thoracic braces prevent thoracic OVCF. 展开更多
关键词 COVID-19 Normalized prevention and control Osteoporotic vertebral compression fracture Risk factor Cough
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From COVID-19 to influenza A-recurrent viral myocarditis and successful immunosuppressive therapy:A case report and review of literature 认领 引用
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作者 Lucia Ilaria Birtolo Federico Ferranti +10 位作者 Giovanna Manzi Annalisa Caputo Gianmarco Scoccia Katia Bruno Nicola Galea Viviana Maestrini Cristina Chimenti Paolo Severino Francesco Pugliese Roberto Badagliacca Carmine Dario Vizza 《World Journal of Cardiology》 2026年第6期129-139,共11页
BACKGROUND Myocarditis is an inflammatory disease of the myocardium with a highly variable clinical presentation and is often triggered by viral infections.While corticosteroids have historically been used with cautio... BACKGROUND Myocarditis is an inflammatory disease of the myocardium with a highly variable clinical presentation and is often triggered by viral infections.While corticosteroids have historically been used with caution in viral myocarditis due to concerns over impaired viral clearance,recent insights from the coronavirus disease 2019 pandemic suggest that their use may offer clinical benefits in selected cases.Whether such benefits extend to other viral etiologies,including influenza,remains uncertain.We report a case of recurrent viral myocarditis in a young woman,initially following severe acute respiratory syndrome coronavirus 2(SARSCoV-2)infection and later associated with influenza A(H1N1),illustrating diagnostic and therapeutic challenges.CASE SUMMARY A previously healthy 27-year-old woman presented with fulminant myocarditis after a paucisymptomatic SARSCoV-2 infection.The initial episode was characterized by pericardial effusion,rapidly progressing to cardiogenic shock and severe left ventricular dysfunction,requiring veno-arterial extracorporeal membrane oxygenation.Empirical high-dose corticosteroid therapy,remdesivir,and monoclonal anti-SARS-CoV-2 antibodies led to complete recovery of cardiac function.Two years later,the patient developed recurrent myocarditis triggered by H1N1,presenting with chest pain,elevated cardiac biomarkers,and severe reduction in ejection fraction.Cardiac magnetic resonance confirmed acute myocarditis with severe left ventricular dysfunction.High-dose corticosteroids and levosimendan were administered,resulting in progressive improvement without the need for mechanical support.At discharge,following both episodes,the patient was asymptomatic and had a complete recovery of the left ventricular ejection fraction.Genetic testing was performed to investigate possible predisposition.CONCLUSION This case highlights the diagnostic and therapeutic challenges of recurrent viral myocarditis,as well as the potential role of immunosuppression. 展开更多
关键词 Myocarditis COVID-19 Influenza A Immunosuppressive therapy Corticosteroids Veno-arterial extracorporeal membrane oxygenation Cardiac magnetic resonance Genetic predisposition Case report
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Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating the diagnostic potential of HLA (rs1131500), IGF-2, and I-FABP 认领 引用
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作者 Amal Ahmed Mohamed Rasha M Abdel-Hamid +10 位作者 Amr Amin Eman Al Hussain A Gawad Salma MohamedSaed Dalia A Gaber Mohamed Ezz Al Arab Waleed El-Agawy Mohammed Zakaria Ali AbuRahma HebaHanafy Elosaily Elsaeed E Shaaban Shaymaa A Ismail Amany A Sakr 《World Journal of Hepatology》 2026年第3期94-111,共18页
BACKGROUND The human leukocyte antigen(HLA)system represents one of the most genetically diverse and densely packed genomic regions,playing a fundamental role in orchestrating immune responses.Among molecular markers ... BACKGROUND The human leukocyte antigen(HLA)system represents one of the most genetically diverse and densely packed genomic regions,playing a fundamental role in orchestrating immune responses.Among molecular markers linked to viral pathogenesis and immune modulation are insulin-like growth factor 2(IGF-2)and intestinal fattyacid-binding protein(I-FABP).AIM To investigate the influence of the HLA variant rs1131500,together with IGF-2 and I-FABP,on susceptibility to hepatitis C virus(HCV),coronavirus disease 2019(COVID-19),and their co-occurrence,to identify predictive biomarkers and potential therapeutic targets.METHODS The study involved quantifying circulating levels of IGF-2,I-FABP,and interferon-gamma(IFN-γ)and genotyping HLA rs1131500 using real-time polymerase chain reaction.Participants provided nasopharyngeal swabs for detection of severe acute respiratory syndrome coronavirus 2 RNA and blood samples for HCV RNA analysis and biomarker assessment.RESULTS Levels of IGF-2 and I-FABP were notably higher in all patient categories,with the highest values observed in coinfected individuals(P<0.0001).A moderate positive correlation was observed between I-FABP and IFN-γin COVID-19 cases(r=0.261,P=0.05).IGF-2 had the most substantial predictive value(odds ratio[OR]:4.5-5.5),while IFN-γshowed a protective trend(OR<1)when combined with IGF-2 and I-FABP.CONCLUSION IGF-2 emerged as the most consistent and reliable biomarker across all patient groups,particularly in COVID-19 and co-infections.I-FABP was a strong marker for co-infection,less so for COVID-19,and ineffective for HCV alone.Genetically,the CC genotype was more common in the HCV and Control groups,whereas the TT genotype was associated with COVID-19 and co-infection,suggesting potential diagnostic value. 展开更多
关键词 COVID-19 Hepatitis C virus Immunogenetics Human leukocyte antigen(rs1131500) Insulin-like growth factor-2 Intestinal fatty-acid-binding protein Biomarkers
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Liver injury after COVID-19 vaccination:Current status and future perspectives 认领 引用
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作者 Ken Sato 《World Journal of Hepatology》 2026年第5期89-106,共18页
Coronavirus disease 2019(COVID-19)vaccination has reduced the morbidity and severity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections and has resulted in many benefits for humans.Conversely,alt... Coronavirus disease 2019(COVID-19)vaccination has reduced the morbidity and severity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections and has resulted in many benefits for humans.Conversely,although not frequent,hepatic injury,such as autoimmune hepatitis and drug-induced liver injury due to COVID-19 vaccination,has been observed in scattered cases.Furthermore,recent increases in the number of case series publications have progressively contributed to the understanding of the pathophysiological mechanisms,clinical management strategies,and prognostic implications associated with post-COVID-19 liver injury.Nonetheless,several critical aspects remain to be elucidated,including the optimal timing for initiating therapeutic interventions,the criteria for their discontinuation,and the clinical appropriateness of vaccine rechallenge.Here,I comprehensively review the literature concerning liver injury after COVID-19 vaccination and discuss possible measures to help prevent unexpected liver injury after COVID-19 vaccination considering the expected continued future occurrence of SARS-CoV-2 infection. 展开更多
关键词 SARS-CoV-2 COVID-19 Vaccination Liver injury Autoimmunity
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Occupational Burnout and Depressive Symptoms among Resident Physicians at Shanghai Tenth People’s Hospital in the Early Post-COVID-19 Period:A Cross-Sectional Study 认领 引用
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作者 Zhui Ke Jie Gao +4 位作者 Yini Zhao Jingyi Lu Xinpei Luo Xuemin He Jin Li 《Asia Pacific Journal of Clinical Medical Research》 2026年第3期31-38,共8页
Background:Resident physicians may experience persistent occupational and psychological strain during the early post-COVID-19 period.Burnout and depressive symptoms can overlap,but they represent diff erent aspects of... Background:Resident physicians may experience persistent occupational and psychological strain during the early post-COVID-19 period.Burnout and depressive symptoms can overlap,but they represent diff erent aspects of psychological burden and should be assessed using standardized instruments.Objective:To estimate the prevalence of occupational burnout and SDS-defined depressive symptoms among resident physicians undergoing standardized residency training at Shanghai Tenth People’s Hospital and to examine the association between burnout scores and depressive-symptom severity.Methods:This single-center cross-sectional anonymous questionnaire study was conducted at Shanghai Tenth People’s Hospital,Shanghai,China,from January to June 2023.A total of 132 eligible resident physicians were invited through hospital residency-training coordination,and all 132 returned questionnaires(response rate,100.0%).Occupational burnout was assessed using a Chinese burnout questionnaire structured around the MBI-GS dimensions,and depressive symptoms were assessed using the validated Chinese Self-Rating Depression Scale(SDS).Internal consistency was assessed using Cronbach’s alpha.Prevalence estimates were reported with Wilson 95%confi dence intervals(CIs).Pearson correlation and multivariable linear regression were used to examine the association between burnout score and SDS standard score.Results:Overall,102/132(77.3%;95%CI,69.4 to 83.6)residents met the predefined burnout criterion.In complete valid SDS responses,81/124(65.3%;95%CI,56.6 to 73.1)residents had SDS-defi ned depressive symptoms.Cronbach’s alpha was 0.887 for the burnout questionnaire and 0.861 for the SDS.Burnout score was positively correlated with SDS standard score(n=124;r=0.64,95%CI,0.52 to 0.73;p<0.001).In multivariable linear regression,burnout score remained positively associated with SDS standard score after adjustment for sex,age group,training duration,and grouped specialty(adjusted beta=0.35,95%CI,0.27 to 0.44;p<0.001).Conclusions:Occupational burnout and SDS-defined depressive symptoms were common among resident physicians at Shanghai Tenth People’s Hospital in the early post-COVID-19 period.The fi ndings suggest that routine screening,workload management,mentorship,and accessible psychological support may be useful for residents at risk.Because this was a cross-sectional study,causality cannot be inferred. 展开更多
关键词 COVID-19 Burnout Depressive Symptoms Resident Physicians Mental Health Standardized Residency Training
Dynamic immune response and its influencing factors in COVID-19 patients with non-alcoholic fatty liver disease:A cohort study 认领 引用 被引量：1
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作者 Pan Yan Rui Li +4 位作者 Xiao-Yan Yuan Yong Wang Li-Juan Lan Xiao-Ping Yu Da-Feng Liu 《World Journal of Hepatology》 2026年第2期101-125,共25页
BACKGROUND Dynamic alterations in lymphocyte subsets demonstrate significant correlations with clinical disease severity in patients with coronavirus disease 2019(COVID-19).As the most prevalent chronic liver disease ... BACKGROUND Dynamic alterations in lymphocyte subsets demonstrate significant correlations with clinical disease severity in patients with coronavirus disease 2019(COVID-19).As the most prevalent chronic liver disease globally,non-alcoholic fatty liver disease(NAFLD)exhibits distinct chronic inflammatory and immunometabolic disturbances that may substantially affect immune response patterns in COVID-19 patients.Nevertheless,the characteristics of lymphocyte subset dynamics and their clinical implications in COVID-19-NAFLD remain to be fully elucidated.AIM To characterize the dynamic changes in lymphocyte subsets among COVID-19 patients with NAFLD,in order to delineate their immunological profiles and inform clinical management strategies.METHODS The cohort study compared lymphocyte subpopulations in 858 COVID-19 patients and 670 COVID-19-NAFLD patients at admission,discharge,and 2-week/4-week post-discharge follow-ups.RESULTS Compared to COVID-19 patients without NAFLD,NAFLD-comorbid patients demonstrated persistently elevated CD3+CD4+counts as well as lymphocyte counts and percentages at admission and at the 2-week and 4-week follow-ups post-discharge(all P<0.05).Among COVID-19-NAFLD patients,those aged≥60 years had significantly lower CD3+counts,CD3+CD4+counts,CD3+CD8+counts,lymphocyte counts and percentages,and CD19+counts and percentages at all assessed time points(all P<0.05);significant liver fibrosis correlated with reduced CD3+CD4+counts,CD3+CD8+counts,and lymphocyte counts and percentages across all time points(all P<0.05);multimorbidity(≥3 comorbidities)exacerbated immune imbalance,marked by elevated CD3+CD4+percentages and CD56+counts at admission,increased CD3+CD4+counts,lymphocyte counts,and CD19+counts and percentages at discharge,as well as sustained increases in CD3+CD4+counts at the 2-week follow-up and higher CD3+CD4+percentages at the 4-week post-discharge follow-up(all P<0.05);and obesity and elevated liver enzymes were independently linked to higher CD3+CD4+counts,CD19+counts,and lymphocyte counts at all post-admission evaluations(from discharge through the 4-week follow-up)(all P<0.05).CONCLUSION Age,liver fibrosis,comorbidities,obesity,liver enzyme abnormalities,vaccination status,low-density lipoprotein cholesterol,and hemoglobin A1c significantly modulate immune responses in COVID-19-NAFLD patients,warranting targeted clinical attention.Furthermore,patients with uncomplicated NAFLD(including lean NAFLD)also require particular clinical attention to mitigate risks of immune imbalance. 展开更多
关键词 COVID-19 Non-alcoholic fatty liver disease Lymphocyte subsets Dynamic immune response Risk factors
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Evaluation of post COVID-19 conditions and functional disabilities:A cross-sectional survey 认领 引用
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作者 Renu Mittal Shweta Singh +14 位作者 Gurudev Choubey Laijun Nahar Brunda Bezwada Nitu Barod Divya Taneja G.Ravi Chandra Reddy D Karthikeyan Ashish Mahajan Ramesh Bawaskar Madhumita Sadhukhan Arun Krishnan P Kumar Vivekanand Ravi Kumar Sardala Subhash Kaushik Scheduled Caste Sub-Plan study group 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第5期210-221,I0001,I0002,共12页
Objective:To assess the prevalence of post COVID-19 conditions,functional disability impacting daily living,and associated socio-demographic determinants.Methods:In this cross-sectional door-to-door survey,post COVID-... Objective:To assess the prevalence of post COVID-19 conditions,functional disability impacting daily living,and associated socio-demographic determinants.Methods:In this cross-sectional door-to-door survey,post COVID-19 conditions were identified.Functional impairment was assessed using EuroQoL five-dimension five-level(EQ-5D-5L)questionnaire.Relative risk of symptoms in the COVID-19 positive group as compared to the symptoms in the COVID-19 negative group was calculated.Chi-square test with subsequent Bonferroni's correction was performed to analyze the association of symptoms with age categories,sex and severity of infection.P value<0.05 was considered to be statistically significant.Results:Out of 57610 persons surveyed,COVID-19 test reports were available for 34602(1799 positive and 32803 negative)respondents.Post COVID-19 complaints were significantly more prevalent in infected individuals,including loss of taste(RR 8.82,95%CI 4.77-16.31,P<0.01),loss of smell(RR 7.29,95%CI 3.74-14.22,P<0.01),fatigue(RR 2.97,95%CI 2.56-3.44,P<0.01),muscle pains(RR 1.86,95%CI 1.59-2.18,P<0.01).EQ-5D-5L scores reflected greater difficulty in mobility,self-care,daily activities,and mental health among the infected group,especially in moderate to severe cases.Conclusions:The survey highlights a significantly higher burden of post COVID-19 complaints and functional limitations among COVID-19 positive individuals.These findings underscore the necessity for long-term management strategies to mitigate the burden of post COVID-19 conditions and poor functional status. 展开更多
关键词 Arsenic album Cough EQ-5D-5L questionnaire Fatigue Post COVID-19 Post COVID-19 functional status Scheduled Castes
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Advances in human respiratory organoid models for studying the pathogenesis and intervention strategies of COVID-19 认领 引用
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作者 Zeping Shan Jiarui Li +7 位作者 Zihui Ye Yuyue Chen Jie Chen Yuewen Chen Xiaofan Wang Chong Gao Shibo Jiang Naru Zhang 《Virologica Sinica》 SCIE CAS CSCD 2026年第1期23-34,共12页
Coronavirus Disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),affects multiple organ systems,with the respiratory system being the primary target.Respiratory organoids,wh... Coronavirus Disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),affects multiple organ systems,with the respiratory system being the primary target.Respiratory organoids,which closely mimic the structure and function of the human respiratory tract,have emerged as essential tools for studying SARS-CoV-2 infection.This review summarizes current methods for generating various respiratory organoids,including nasal,tonsil,airway,bronchial,and alveolar organoids,and highlights their application in investigating the mechanism of SARS-CoV-2 infection and evaluating potential therapeutic agents.Meanwhile,this review also introduces respira-tory organoid-on-a-chip technology,which can precisely regulate culture conditions and incorporate vascularization and immune cells to enhance physiological complexity,thereby providing crucial support for investigating SARS-CoV-2-induced lung injury,immune responses,and conducting high-throughput drug screening.The aim of this review is to provide valuable insights for further research into the pathogenesis and intervention strategies of COvID-19. 展开更多
关键词 COVID-19 SARS-CoV-2 Respiratory organoids
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Evaluating acupuncture as a therapeutic intervention for post-COVID-19 olfactory dysfunction:a systematic review and pilot study 认领 引用
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作者 Dongjue Wei Choryin Leung +9 位作者 Alan Yatlun Wong Shu Yang Peipei Du Yiping Wong Bacon FL Ng Rowena Wong Ka Ming Yau Hungwai Cho Chifung Choy Lidan Zhong 《Acupuncture and Herbal Medicine》 CAS CSCD 2026年第1期105-118,共14页
Objective:Olfactory dysfunction(OD)is a common and persistent symptom of coronavirus disease 2019(COVID-19)for which effective treatments remain limited.Acupuncture,widely used in Chinese medicine for olfactory disord... Objective:Olfactory dysfunction(OD)is a common and persistent symptom of coronavirus disease 2019(COVID-19)for which effective treatments remain limited.Acupuncture,widely used in Chinese medicine for olfactory disorders has uncertain efficacy in post-COVID-19 OD.Therefore,in this study,we aimed to explore the feasibility and preliminary efficacy of acupuncture in patients with post-COVID-19 OD.Methods:This study was a dual-phased study.Phase I involved a systematic review conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,encompassing eight databases.Phase II consisted of a pilot randomized controlled trial(RCT)enrolling 25 patients with moderate to severe post-COVID-19 OD.Participants were randomly assigned to receive either real(group A)or sham(group B)acupuncture.The intervention included eight sessions over 4 weeks,with assessments at baseline,post-cycle 1,2-week washout,post-cycle-2 treatment,and 2-week follow-up.The primary outcome was the change in scores on the 12-item Assessment of Self-Reported Olfactory Functioning and Quality of Life(ASOF).Secondary outcomes included the short version of the Questionnaire of Olfactory Disorders-Negative Statements(sQOD-NS)and the traditional Chinese version of the University of Pennsylvania Smell Identification Test(UPSIT-TC).Results:The systematic review identified 22 studies(15 case reports,seven RCTs)suggesting that acupuncture may positively influence olfactory function.In the pilot RCT,no significant baseline differences were observed between groups.Group A showed steady improvement across all ASOF domains during Cycle 1(SOC,mean=5.86;SRP,mean=3.26;ORQ,mean=3.98),with slight declines during cycle 2 and 2-week follow-up,though scores remained above baseline.Post-cycle 1,group A showed higher mean SOC and ORQ scores compared with group B(7.00 vs.4.67;3.98 vs.3.39).Improvements in secondary outcomes were also more pronounced in group A,whereas group B showed minimal changes.Conclusion:Acupuncture appears to be a safe and potentially effective treatment for post-COVID-19 OD,warranting validation through larger clinical trials. 展开更多
关键词 Acupuncture COVID-19 Olfactory dysfunction Pilot study Systematic literature review
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Health risk of PM2.5-bound heavy metals in a megacity in South China:Comparison between before and after the outbreak of COVID-19 认领 引用
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作者 Runhua Wang Xing Peng +9 位作者 Kejin Tang Yu Han Jiangyao Tan Ning Feng Shaoxia Wang Liwu Zeng Xiaofeng Huang Lingyan He Sihua Lu Min Hu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期842-851,共10页
The COVID-19 pandemic led to three years(2020-2022)of human activity restrictions in China,significantly impacting urban air quality,yet long-term health risks from PM2.5-bound heavy metals remain unclear.This stud... The COVID-19 pandemic led to three years(2020-2022)of human activity restrictions in China,significantly impacting urban air quality,yet long-term health risks from PM2.5-bound heavy metals remain unclear.This study observed PM2.5 and 21 associated metals in Shenzhen over six years(2017-2022),aiming to identify sources,assess their health impacts,and explore COVID-19 effects on health risks.The total carcinogenic risk(CR)of 5 metals decreased by 23%during the pandemic(2020-2022)compared to pre-pandemic levels(2017-2019),similar to the trends of PM2.5 and total metals concentrations.In contrast,the non-carcinogenic risk(NCR)of 11 metals increased by 20%,primarily due to the rise in manganese(Mn)concentration caused by vehicle emissions,but NCR still below the risk threshold.Vehicle emissions were the main contributor to NCR(68%)and CR(55%).Machine learning revealed that the source emissions reduction is the primary factor contributing to the decline in the CR of metals bound to PM2.5,except for the increased health risk associated with vehicles.During the pandemic,the slowed growth rate of CR of vehicle emissions and the significant decline in CR of fugitive dust demonstrated the effectiveness of pandemic-induced traffic and production restrictions in reducing anthropogenic emissions and mitigating PM2.5-bound heavy metal health risks in Shenzhen.However,total CR of heavy metals in 2022 exceeded the acceptable risk threshold(1×10-6),emphasizing the ongoing challenge of regulating PM2.5 and the need to prioritize vehicle emission management. 展开更多
关键词 PM2.5 Positive matrix factorization Heavy metals Health risks Sources analysis COVID-19
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Fusion for Classification of COVID-19 Patients Using a Discriminative Shape-Texture Convolutional Neural Network with X-Ray Images and Speech Signal Processing 认领 引用
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作者 R.Venkatesh A.Shenbagarajan G.Shenbagalakshmi 《Journal of Bionic Engineering》 SCIE EI CSCD 2026年第3期1899-1917,共19页
Accurate and quick diagnosis of COVID-19 remains a global challenge,as conventional RT-PCR testing suffers from high false-negative rates,delays,and limited availability.Chest X-ray imaging,while more accessible,requi... Accurate and quick diagnosis of COVID-19 remains a global challenge,as conventional RT-PCR testing suffers from high false-negative rates,delays,and limited availability.Chest X-ray imaging,while more accessible,requires expert interpretation and is prone to human error.Although several deep learning methods have been applied,many face issues of overfitting,insufficient feature selection,and reduced reliability.In order to overcome these constraints,we suggest a hybrid framework,COVID-19-DSCNN-XISSP,which integrates a Deep Spatial Convolutional Neural Network(DSCNN)for robust spatial excision of features with the Exponential Incremental Social Ski Driver with Sine Cosine Algorithm(XISSP)for optimal feature selection.This strategy enhances classification accuracy while reducing computational overhead.Extensive experiments on benchmark COVID-19 chest X-ray datasets demonstrate that the proposed model outperforms existing approaches in terms of accuracy,precision,and robustness.The findings highlight the potential of COVID-19-DSCNN-XISSP as an economical,automated,and expandable tool for assisting radiologists in early and reliable detection of COVID-19,thereby supporting improved clinical decision-making and pandemic control. 展开更多
关键词 Bayesian boundary trend filtering COVID-19 Shape-texture discriminative convolutional neural network Lung area specific COVID-19 Xray dataset Multi‐hypothesis fuzzy‐matching radon transform Snow ablation optimizer
COVID-19后遗症心肌损伤的诊疗进展 认领 引用
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作者 陈义萍 张剑梅 +3 位作者 厉彦虎 李睿 张瑞平 杨萍 《中国全科医学》 CAS 北大核心 2026年第18期2585-2592,共8页
COVID-19后遗症(PCC)心肌损伤患者表现出心悸、胸闷、胸痛等多种心脏相关症状,但没有心血管疾病的客观证据。近年来,PCC心肌损伤作为一种新发病症,诊断和治疗缺乏循证医学证据支持。临床对该病症的诊疗经验不足,易导致患者病情迁延不愈... COVID-19后遗症(PCC)心肌损伤患者表现出心悸、胸闷、胸痛等多种心脏相关症状,但没有心血管疾病的客观证据。近年来,PCC心肌损伤作为一种新发病症,诊断和治疗缺乏循证医学证据支持。临床对该病症的诊疗经验不足,易导致患者病情迁延不愈,生活质量下降。因此,本文重点探讨PCC心肌损伤的诊断、临床治疗与康复的最新研究进展,提高临床工作者对这一疾病的认识。 展开更多
关键词 新型冠状病毒感染 COVID-19后遗症 心肌疾病 诊断与治疗 综述
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基于骨架化DTI评估COVID-19康复患者脑白质损伤 认领 引用
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作者 郑秀梅 陈凯骁 +2 位作者 王瑶 周福庆 吴麟 《放射学实践》 CAS CSCD 北大核心 2026年第4期369-374,共6页
目的:基于骨架化平均扩散率的峰宽(PSMD)等DTI衍生参数评估COVID-19康复患者全脑白质的完整性,及其与神经症状评估量表得分的相关性,旨在了解COVID-19康复患者脑白质改变。方法:2023年2月-2023年7月招募91例COVID-19康复半年内受试者和6... 目的:基于骨架化平均扩散率的峰宽(PSMD)等DTI衍生参数评估COVID-19康复患者全脑白质的完整性,及其与神经症状评估量表得分的相关性,旨在了解COVID-19康复患者脑白质改变。方法:2023年2月-2023年7月招募91例COVID-19康复半年内受试者和60例健康志愿者(HC)。COVID康复组中39例存在失眠、记忆力下降、乏力等后遗症,52例无明确后遗症。在患者康复出院后平均132天内进行脑部MRI扫描,并采用9种临床量表对患者的认知功能进行评估,包括蒙特利尔认知功能评估量表(MoCAs)、汉密尔顿焦虑量表(HAMA)、广泛性焦虑障碍-7(GAD-7)、汉密尔顿抑郁量表(HAMD)、患者健康问卷-9(PHQ-9)、疲劳严重程度量表(FSS)、匹兹堡睡眠质量指数(PSQI)、简易精神状态检查(MMSE)和视觉模拟量表(VAS)。将所有被试的平均扩散率(MD)图像配准至标准空间构建全脑白质骨架,仅保留双侧大脑半球主要白质纤维束,包括胼胝体、放射冠、内囊、外囊及额、顶、颞和枕叶的深部白质等。分析所有被试者的DTI数据,测量双侧大脑半球主要白质纤维束的骨架化平均扩散率的峰宽(PSMD)、骨架化平均扩散率的均值(MSMD)、骨架化各向异性分数的峰宽(PSFA)和骨架化各向分数异性的均值(MSFA)等差异骨架化衍生DTI参数并进行组间比较。采用Pearson相关性分析对COVID-19康复组的DTI参数与各项临床量表评分进行相关性分析。结果:与HC组相比,COVID-19后遗症组的PSMD和MSMD值显著升高,PSFA值和MSFA值显著降低(P均<0.05);无后遗症组的MSMD、PSFA和MSFA值与HC组的差异均具有统计学意义(P<0.05)。后遗症组MSFA值低于无后遗症组(t=-2.148,P=0.034)。后遗症组的PSMD值与MoCA评分呈负相关(r=-0.342,P=0.030)。结论:COVID-19感染康复后半年内患者存在脑白质损伤,且有后遗症组的脑白质损伤与认知功能下降具有相关性。 展开更多
关键词 COVID-19 脑白质 扩散张量成像 平均扩散率 认知功能
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重症监护病房患者COVID-19相关肺曲霉病感染危险因素的Meta分析 认领 引用
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作者 韩镕徽 刘晓琳 眭玉霞 《中国感染控制杂志》 CAS CSCD 北大核心 2026年第1期47-59,共13页
目的系统评价重症监护病房(ICU)患者新型冠状病毒感染(COVID-19)相关肺曲霉病(CAPA)感染危险因素。方法计算机检索PubMed、Cochrane Library、Embase、Web of Science、中国知网(CNKI)、万方数据、维普数据库(VIP)中关于ICU患者CAPA感... 目的系统评价重症监护病房(ICU)患者新型冠状病毒感染(COVID-19)相关肺曲霉病(CAPA)感染危险因素。方法计算机检索PubMed、Cochrane Library、Embase、Web of Science、中国知网(CNKI)、万方数据、维普数据库(VIP)中关于ICU患者CAPA感染危险因素的研究,检索时限均为建库至2025年3月31日。由2名研究者独立筛选文献与提取资料,采用纽卡斯尔-渥太华(NOS)量表进行质量评价,使用RevMan 5.4软件进行Meta分析。结果共纳入38篇观察性研究,包括11312例患者。Meta分析结果显示,男性、年龄、吸烟、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ评分)、简化急性生理学评分Ⅱ(SAPSⅡ评分)、肝硬化、糖尿病、慢性阻塞性肺疾病(COPD)、心血管疾病、EORTC/MSGERC宿主因素、实体器官移植、血液系统恶性肿瘤、长期使用糖皮质激素、免疫缺陷、Charlson合并症指数、使用血管活性药物和/或正性肌力药物、接受机械通气、侵入性机械通气、机械通气时间、肾脏替代治疗、白细胞介素-6(IL-6)抑制剂治疗等因素均为ICU患者CAPA感染危险因素。身体质量指数(BMI)高和肥胖均为ICU患者CAPA感染的保护性因素(均P<0.05)。结论ICU患者CAPA感染危险因素较多,及时识别相关危险因素有助于尽早实施规范的抗真菌治疗,从而改善患者预后。 展开更多
关键词 COVID-19相关肺曲霉病 重症监护病房 危险因素 Meta分析
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