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Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice 认领 引用 被引量：1
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作者 Xiao-Li Xu Ting-Ting Luo +8 位作者 Qi Liu Gu-Zhen Cui Dao-Yan Wu Xiao-Juan Wu Ting-Xiu Yang Jian-Chao Sun Hui-Feng Jian Shu-Wei Zhuo Zheng-Hong Chen 《World Journal of Gastroenterology》 SCIE CAS 2026年第7期135-155,共21页
BACKGROUND Although Helicobacter pylori(H.pylori)can cause a range of gastric diseases and affects approximately 50% of the global population,its routes of transmission have yet to be sufficiently clarified.In a preli... BACKGROUND Although Helicobacter pylori(H.pylori)can cause a range of gastric diseases and affects approximately 50% of the global population,its routes of transmission have yet to be sufficiently clarified.In a preliminary study,we found that H.pylori can reside within the cells of Candida yeasts,with maternal Candida serving as a potential reservoir for the transmission of H.pylori to neonates during delivery.AIM To study the route of H.pylori transmission from mothers to offspring.METHODS We established vaginal and gastric infection models using female C57BL/6J mice infected with H.pylori 16S rDNA and urease A(ureA)genes-positive Candida.The successfully infective female mice were then mated with normal male mice until conception(classified vaginal and cesarean deliveries).The H.pylori infection status in female mice and their offspring was assessed using enzyme-linked immunosorbent assay,polymerase chain reaction,Candida isolation and culture,and histopathological examination.RESULTS The enzyme-linked immunosorbent assay results showed an increase in H.pylori-specific IgG and IgM serum antibodies in the H.pylori-positive Candida group maternal and offspring mice compared to the control and normal groups.H.pylori 16S rDNA or ureA genes was detected in samples from some of the maternal and offspring mice,including gastric mucosa,intestinal contents,vaginal tissue,placenta,and fetal membranes.In addition,H.pylori 16S rDNA-or ureA gene-positive Candida were successfully isolated from the tissues of some postpartum maternal and offspring mice.Moreover,histopathological examination revealed bleeding spots and inflammatory cell infiltration in the gastric mucosal tissues of some maternal mice and offspring in the H.pylori-positive Candida group.CONCLUSION In conclusion,H.pylori infection of newborns may be acquired through vertical transmission during childbirth,potentially originating from the mother’s Candida that has been internalized by H.pylori. 展开更多
关键词 Helicobacter pylori Candida Internalization Reservoir Vertical transmission
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Beyond fecal-oral routes-Candida as a reservoir for vertical transmission of Helicobacter pylori:Insights from a murine model 认领 引用
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作者 Zeinab Nabil Ahmed Said Sabah Mohamed Alkhawagah 《World Journal of Gastroenterology》 SCIE CAS 2026年第24期1-6,共6页
In this editorial,we comment on the article published in the World Journal of Gastroenterology by Xu et al.This article experimentally investigated the route of Helicobacter pylori(H.pylori)transmission of Candida har... In this editorial,we comment on the article published in the World Journal of Gastroenterology by Xu et al.This article experimentally investigated the route of Helicobacter pylori(H.pylori)transmission of Candida harboring H.pylori from mothers to offspring using murine vaginal and gastric infection models.The study showed serological evidence of H.pylori infection and molecular detection of H.pylori genes in multiple tissues in the infected maternal mice,accompanied by marked gastric inflammation,indicating the release of viable,pathogenic H.pylori from Candida.In addition,it also reported that the offspring mice exhibited H.pylorispecific antibodies and molecular evidence of infection,regardless of the delivery mode,strongly supporting maternal–neonatal transmission.The authors concluded that H.pylori infection in newborns may be acquired through vertical transmission during childbirth,possibly originating from maternal Candida that has been internalized by H.pylori.This editorial focuses specifically on the possibility that H.pylori can reside within the cells of Candida yeasts that colonize the maternal vagina,addressing the risk of its transmission to offspring.A comprehensive understanding of the transmission routes of H.pylori will help guide the implementation of effective infection prevention and control measures. 展开更多
关键词 Candida Helicobacter pylori Polymicrobial interaction Neonates Vertical transmission
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Clinical significance of a possible route of transmission of Candida and Helicobacter pylori associations in gastroduodenal pathology 认领 引用
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作者 Sergey M Kotelevets 《World Journal of Gastrointestinal Pathophysiology》 2026年第1期60-63,共4页
Fungal and bacterial interactions are widespread in the environment.Such intraabdominal co-infections may lead to sepsis,potentially resulting in significant mortality.Interactions between invasive fungi(Candida)and p... Fungal and bacterial interactions are widespread in the environment.Such intraabdominal co-infections may lead to sepsis,potentially resulting in significant mortality.Interactions between invasive fungi(Candida)and pathogenic bacteria[Helicobacter pylori(H.pylori)]appear to be particularly relevant to human infection outcomes.Co-colonization by fungi and bacteria(coinfections)remains a pressing issue among patients with gastrointestinal pathology;however,the transmission routes and pathogenic mechanisms of these microbiome interactions are not yet fully understood.Candida species are known to support the growth of certain bacteria,and studies have observed a significant increase in the colony counts of these bacteria in the presence of fungi.As an opportunistic pathogen,Candida-in association with H.pylori-may contribute to dysbiosis of the oral microflora and other regions of the gastrointestinal tract,potentially facilitating disease progression.Therefore,understanding the interactions between fungi and bacteria is essential for improving early diagnosis and treatment efficacy.Synergistic effects have been identified in the development of resistance to antifungal and antibacterial therapies.Modern treatment strategies should consider focusing on methods to disrupt this synergy,as well as on preventative measures to limit the transmission of Candida-Helicobacter associations between individuals. 展开更多
关键词 Candida Helicobacter pylori Routes of transmission Fungal and bacterial associations Periodontitis Vulvovaginal candidiasis Microbiota
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A mitochondria-targeted aggregation-induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer 认领 引用 被引量：2
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作者 Kun-Mei Liu Yun Wang +3 位作者 Feng-Wei Xia Shun Feng Xiao-Qi Yu Ming-Yu Wu 《Smart Molecules》 CSCD 2025年第3期1-12,共12页
With increasing drug resistance,Candida infections have posed serious threats to public health.Photodynamic therapy harnesses light to destroy pathomycete,providing a smart strategy for combating of Candida infections... With increasing drug resistance,Candida infections have posed serious threats to public health.Photodynamic therapy harnesses light to destroy pathomycete,providing a smart strategy for combating of Candida infections.However,due to lack of organelle targeting ability and bad extracellular polymeric substances penetrability,current photosensitizers(PSs)are far from desirable to clean biofilms and fight against drug resistance.Herein,a mitochondrion targeting aggregationinduced emission PS,LIQ-TPA-TZ,was developed for the efficient photodynamic treatment of oral Candida infection.LIQ-TPA-TZ has good singlet oxygen and hydroxyl radical generation ability,which can efficiently kill the Candida guilliermondii(C.guilliermondii)and eradicate the biofilm.It not only causes mitochondrial damage by disruption of mitochondrial respiratory chain and oxidative stress-related gene but also inhibits fungal adhesion and filamentous growth to prevent Candida colonization,mycelia growth and biofilm formation,which is favorable for eliminating the potential drug resistance.In the mouse oropharyngeal Candida biofilm infection model,LIQ-TPA-TZ significantly eliminates infection,alleviates inflammation,and accelerates mucosal defect healing.This study provides a favorable strategy for confronting drug resistance,which may be a potential Candidate for the treatment of Candida infection. 展开更多
关键词 aggregation-induced emission biofilm candida infection mitochondrial targeting photosensitizer photodynamics therapy
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Candida albicans and colorectal cancer:A paradoxical role revealed through metabolite profiling and prognostic modeling 认领 引用 被引量：2
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作者 Hao-Ling Zhang Rui Zhao +8 位作者 Di Wang Siti Nurfatimah Mohd Sapudin Badrul Hisham Yahaya Mohammad Syamsul Reza Harun Zhong-Wen Zhang Zhi-Jing Song Yan-Ting Liu Sandai Doblin Ping Lu 《World Journal of Clinical Oncology》 2025年第4期195-279,共85页
BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the para... BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the paradoxical role of C.albicans in CRC,aiming to determine whether it promotes or suppresses tumor development,with a focus on the mechanistic basis linked to its metabolic profile.AIM To investigate the dual role of C.albicans in the development and progression of CRC through metabolite profiling and to establish a prognostic model that integrates the microbial and metabolic interactions in CRC,providing insights into potential therapeutic strategies and clinical outcomes.METHODSA prognostic model integrating C. albicans with CRC was developed, incorporating enrichment analysis, immuneinfiltration profiling, survival analysis, Mendelian randomization, single-cell sequencing, and spatial transcriptomics.The effects of the C. albicans metabolite mixture on CRC cells were subsequently validated in vitro. Theprimary metabolite composition was characterized using liquid chromatography-mass spectrometry.RESULTSA prognostic model based on five specific mRNA markers, EHD4, LIME1, GADD45B, TIMP1, and FDFT1, wasestablished. The C. albicans metabolite mixture significantly reduced CRC cell viability. Post-treatment analysisrevealed a significant decrease in gene expression in HT29 cells, while the expression levels of TIMP1, EHD4, andGADD45B were significantly elevated in HCT116 cells. Conversely, LIME1 expression and that of other CRC celllines showed reductions. In normal colonic epithelial cells (NCM460), GADD45B, TIMP1, and FDFT1 expressionlevels were significantly increased, while LIME1 and EHD4 levels were markedly reduced. Following metabolitetreatment, the invasive and migratory capabilities of NCM460, HT29, and HCT116 cells were reduced. Quantitativeanalysis of extracellular ATP post-treatment showed a significant elevation (P < 0.01). The C. albicans metabolitemixture had no effect on reactive oxygen species accumulation in CRC cells but led to a reduction in mitochondrialmembrane potential, increased intracellular lipid peroxidation, and induced apoptosis. Metabolomic profilingrevealed significant alterations, with 516 metabolites upregulated and 531 downregulated.CONCLUSIONThis study introduced a novel prognostic model for CRC risk assessment. The findings suggested that the C.albicans metabolite mixture exerted an inhibitory effect on CRC initiation. 展开更多
关键词 Candida albicans Colorectal cancer Metabolic characteristics Extracellular ATP Prognostic model
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Electrophysiological and olfactory behavioural responses of mature Stilpnotia candida to a mixture of volatiles from Populus×beijingensis 认领 引用
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作者 Zepeng Yang Zhenhao Song +3 位作者 Xiaoqin Tang Lu Jie Yiqu Cheng Jiancheng Zang 《Journal of Forestry Research》 SCIE EI CAS CSCD 2025年第1期413-425,共13页
This study examined the EAG(Electroantennogram)responses of Stilpnotia candida to a mix of host plant volatiles and to provide a foundation for the development of plant-derived attractants.During the peak period of ad... This study examined the EAG(Electroantennogram)responses of Stilpnotia candida to a mix of host plant volatiles and to provide a foundation for the development of plant-derived attractants.During the peak period of adult eclosion,gas chromatography–mass spectrometry analyzed and identified the volatiles emitted by Populus×beijingensis found in Xizang.Based on the preliminary EAG experiments and the GC‒MS results,a blending scheme was developed.EAG and Y-tube-olfactometry were employed to measure the electrophysiological and behavioural responses of unmated males and females 24 h after eclosion 10 blends of volatiles derived from five host plants.The GC–MS analysis revealed 22 volatile compounds from Populus×beijingensis leaves,composed of esters,hydrocarbons,terpenoids,alcohols,phenols,and ether.The results indicated that all 10 blending schemes produced EAG responses in mature S.candida.The concentration thresholds were between 1 and 10μg·μL-1,above the optimal concentration,and a corresponding decrease in EAG was observed.According to intergroup comparisons,mature S.candida had more pronounced EAG responses.Under different concentrations,there were significant differences in the EAG from male and female S.candida to each blending scheme.Behavioural response tests indicated that schemes 2,7,and 8 exhibited significantly greater attractiveness to adult S.candida.The combined results from the EAG and behavioral response experiments demonstrated that unmated male and female adult S.candida have varying degrees of sensitivity to the volatile compounds from the 10 blending schemes specific to Xizangan Populus×beijingensis.Schemes 2,7,and 8 showed robust EAG responses and attractive behavioural responses to both male and female adult S.candida. 展开更多
关键词 Stilpnotia candida Host volatiles Gas chromatography-mass spectrometry Electroantennogram Y-tube-olfactometer
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新生儿Candida pelliculosa菌血症院内感染的调查研究及危险因素分析 认领 引用
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作者 刘俊保 朱秀凤 +3 位作者 解沛涛 杨飞玉 苏长海 郝朵 《中国真菌学杂志》 CSCD 2025年第4期399-404,共6页
目的对发生在新生儿重症监护病房的Candida pelliculosa菌血症进行分析,探究暴发原因,并对其感染新生儿的相关危险因素进行分析。方法回顾性分析2016年1月1日—2020年3月27日内蒙古自治区鄂尔多斯市中心医院NICU中14名Candida pellicul... 目的对发生在新生儿重症监护病房的Candida pelliculosa菌血症进行分析,探究暴发原因,并对其感染新生儿的相关危险因素进行分析。方法回顾性分析2016年1月1日—2020年3月27日内蒙古自治区鄂尔多斯市中心医院NICU中14名Candida pelliculosa菌血症患儿的临床资料,将其作为实验组,并以1∶4的匹配方式随机抽取无真菌感染患儿56例作为对照组1,抽取非Candida pelliculosa真菌菌血症患儿18例作为对照组2,进行对比研究,分析Candida pelliculosa在新生儿感染中的潜在危险因素。并通过对患儿、医务人员以及环境的检测,分析其感染源。结果Candida pelliculosa感染新生儿的危险因素包括:低出生体重、早产、中心静脉置管、机械通气以及广谱抗生素的使用,其与非Candida pelliculosa的真菌感染危险因素相比,无统计学差异。多因素分析中,仅有出生体重<1500 g与机械通气为感染的独立危险因素。所有患儿在明确诊断后给予氟康唑治疗,均治愈。在患儿、护理人员手上或环境中均未发现Candida pelliculosa,未明确其感染源。Candida pelliculosa引起院内感染的主要原因可能为院内环境定植以及医护人员感控措施不严格所造成。结论Candida pelliculosa为新生儿真菌感染中较为罕见的真菌病原体,与其他念珠菌感染者具有相同的风险因素。由于新生儿较为特殊,医护工作者应严格执行感控措施,更加注意监测暴发的可能性。 展开更多
关键词 Candida pelliculosa 真菌血症 新生儿 危险因素
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Microbiota and cancer:Elucidating the role of Candida albicans in cancer progression 认领 引用
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作者 Di Wang Hao-Ling Zhang +3 位作者 Hao-Long Zhang Zhi-Jing Song Sandai Doblin Ping Lu 《World Journal of Clinical Oncology》 2025年第6期23-33,共11页
Candida albicans(C.albicans)represents one of the most prevalent opportunistic fungal pathogens in cancer patients.Although the association between C.albicans and cancer has been recognized for decades,the causal rela... Candida albicans(C.albicans)represents one of the most prevalent opportunistic fungal pathogens in cancer patients.Although the association between C.albicans and cancer has been recognized for decades,the causal relationship,whether C.albicans infection is a consequence of cancer or a direct contributor to cancer development-remains a subject of intensive investigation.Recently,the complex interplay between microbes and cancer has garnered significant attention within the scientific community,with growing interest in elucidating the underlying molecular mechanisms.This review systematically examines the biological characteristics of C.albicans,its multifaceted interactions with the host,and its relationship with the intestinal microbiota.Additionally,it provides a comprehensive analysis of the association between C.albicans and the development of various malignancies,with particular emphasis on digestive tract cancers.The review also identifies critical knowledge gaps and apparent contradictions in existing research,highlighting potential avenues for breakthroughs that will advance the efficient and accurate screening,diagnosis,and treatment of cancer. 展开更多
关键词 Candida albicans Cancer progression Immune evasion Inflammatory response Tumor microenvironment
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高盐低pH对Candida生物强化处理蜜饯废水的影响 认领 引用 被引量：1
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作者 朱文强 温学哲 +4 位作者 林华丽 崔亮 董纯明 邵宗泽 王勇 《中国给水排水》 CAS CSCD 北大核心 2025年第15期125-134,共10页
蜜饯废水是典型的酸性高盐废水,在实际处理中常需要加水稀释以降低盐度、加碱以调节pH,导致处理成本偏高。为此,利用序批式生物膜反应器(SBBR),以能在酸性高盐条件下生长良好并可提升废水pH的酵母菌Candida作为生物强化剂处理蜜饯废水,... 蜜饯废水是典型的酸性高盐废水,在实际处理中常需要加水稀释以降低盐度、加碱以调节pH,导致处理成本偏高。为此,利用序批式生物膜反应器(SBBR),以能在酸性高盐条件下生长良好并可提升废水pH的酵母菌Candida作为生物强化剂处理蜜饯废水,探讨不同pH和盐度条件下反应器的运行效能和微生物群落结构变化。结果表明,在3.5%盐度下,当初始pH=4.0时SBBR表现最佳,蜜饯废水经处理后pH升至6.0以上,COD、TIN、TP去除率分别可达到83.2%、72.2%、98.7%。在不同的初始pH条件下SBBR中形成独特的微生物群落结构,其中R1(pH=4.0,盐度=5.0%)和R4(pH=4.0,盐度=3.5%)中的优势菌属均为Pseudooceanicola和Candida,R2(pH=2.6,盐度=3.5%)中的优势菌属为Acidovorax和Zygoascus,R3(pH=3.3,盐度=3.5%)中的优势菌属为Oceanobacillus、Vibrio和Candida。环境因子关联性分析结果表明,pH是影响微生物群落结构的关键因素,盐度的增加则影响较小。物种相互作用网络揭示了细菌网络中Oceanobacillus和真菌网络中Rhodotorula的关键作用,在酸性高盐环境下细菌网络中共生和互惠是主要关系,而真菌网络中捕食和竞争是主要关系。 展开更多
关键词 蜜饯废水 酸性高盐 Candida 生物强化 微生物群落结构
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Endoplasmic reticulum stress responses in Candida:mechanisms of pathogenicity and antifungal resistance 认领 引用
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作者 Qiu-Ying Chen Sheng-Qi Jia +2 位作者 Yu-Lan Zeng Zhi-Lin Zeng Lan-Yue Pan 《Infectious Diseases Research》 2025年第3期23-30,共8页
In Candida species,the endoplasmic reticulum(ER)stress response—regulated by the unfolded protein response(UPR)—serves as a critical adaptive mechanism affecting both pathogenicity and antifungal resistance.This rev... In Candida species,the endoplasmic reticulum(ER)stress response—regulated by the unfolded protein response(UPR)—serves as a critical adaptive mechanism affecting both pathogenicity and antifungal resistance.This review aims to synthesize current knowledge on ER stress pathways in Candida glabrata and Candida albicans,highlighting their species-specific adaptations and therapeutic implications.We systematically analyzed peer-reviewed literature on ER stress mechanisms in Candida,focusing on comparative studies of UPR signaling.Emphasis was placed on C.glabrata’s inositol-requiring enzyme 1(IRE1)-dependent Regulated IRE1-Dependent Decay(RIDD)pathway and C.albicans’IRE1/HAC1 and calcium-mediated pathways.Connections to virulence and drug resistance were evaluated through genetic,transcriptomic,and phenotypic evidence.Candida species employ divergent UPR strategies:C.glabrata mitigates ER stress primarily via RIDD-mediated mRNA decay to reduce protein load,while C.albicans enhances folding capacity through HAC1 splicing and calcium homeostasis.These adaptations promote survival in hostile host environments(e.g.,oxidative stress,immune attacks)and are linked to resistance against azoles and echinocandins.Pharmacological disruption of UPR components(e.g.,IRE1 inhibitors)sensitizes Candida to antifungals in experimental models.ER stress response pathways are promising targets for antifungal drug development.Understanding species-specific UPR mechanisms in Candida could guide novel therapies to overcome resistance and improve treatment outcomes. 展开更多
关键词 endoplasmic reticulum stress unfolded protein response Candida glabrata Candida albicans antifungal resistance pathogenicity
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Trends of Candida species causing bloodstream infections in South-Eastern Asia:A systematic review and meta-analysis 认领 引用
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作者 Dina Yamin Abubakar Muhammad Wakil +2 位作者 Mohammed Dauda Goni Ahmad Adebayo Irekeola Khalid Hajissa 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第2期51-66,共16页
A reliable estimation of Candida bloodstream infection prevalence is increasingly important to track changes in Candida species distribution and define burden of ongoing candidemia.A systematic review and meta-analysi... A reliable estimation of Candida bloodstream infection prevalence is increasingly important to track changes in Candida species distribution and define burden of ongoing candidemia.A systematic review and meta-analysis were conducted to estimate candidemia prevalence and identify patterns of Candida species in South-eastern Asia.Systematic electronic-databases literature search was performed on published studies recorded candidemia prevalence in South-Eastern Asia.Using meta-analysis of proportions,the overall pooled prevalences of candidemia by Candida(C.)albicans,C.tropicalis,C.parapsilosis and C.glabrata were calculated as 28.4%(95%CI 24.9-31.8),29.2%(95%CI 24.7-33.7),19.1%(95%CI 14.8-23.4)and 14.0%(95%CI 10.4-17.5),respectively.Based on publication year and country,subgroup analyses were conducted on Candida species to determine heterogeneity source.The findings may not precisely reflect true candidemia prevalence in different countries.Therefore,it highlights continuous need to conduct prevalence studies,assess and monitor growing burden,control effect of potential risk factors and implement regional surveillance programs to prevent further rise. 展开更多
关键词 Candida species Candidemia Bloodstream infections Prevalence South-Eastern Asia Systematic review and meta-analysis
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Intracerebroventricular injection of Candida albicans induces fungal encephalitis with distinct magnetic resonance imaging characteristics 认领 引用
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作者 Mingsheng Li Jing Ai +4 位作者 Shuze Li Jiakang Chen Hongying Jin Zhihong Zhang Xiang Yu 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第5期69-78,共10页
Candida albicans(C.abicans),вcommon pathogenic fungus in nature,has enough cæpity to cause Severe brain infection through various mesns under immunocompromised conditions.Currently,stablishing a basic animal dis... Candida albicans(C.abicans),вcommon pathogenic fungus in nature,has enough cæpity to cause Severe brain infection through various mesns under immunocompromised conditions.Currently,stablishing a basic animal disesse model has become the main rsrch tool,which isconducive to simulat ing fungal encephalitis effectively.However,the widely used bloodbarne infection model established by intravenoOus(I.V)injection in mice usually results in systenic infecions but cannot simulate significant bradn inflammation.Here,we developed&fungal en-cephaltis model by intracerebroventriaular(L.C.V)injection af C.albicansto better simulate the significant harm und consequencEs.Compared with I.V,a greater number of colony-for ming units(CFUa)in the brain was induced following I.CV.Magnetic resonane imaging MRM resulta revesled more obvious inflammatinn in the external capsule area of the brain.Menwhile,be havioral experiments with the Y-meze also indicated that abnormal activity behavior further relected significant short-term mamory impairment after I.C.Vof C.albicans.In summary,these studies not onby provide a novel fungal encephalitis model for understanding the pathogenesis mechanism of this disease but also lay a solid foundation for future effective tretment. 展开更多
关键词 Candida albicans infection magnetic resonane imaging:fungal encephalitis animal model inflammation.
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Commensal Oral Candida in Asian Cohorts 认领 引用 被引量：4
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作者 Lakshman Samaranayake 《International Journal of Oral Science》 SCIE CAS 2009年第1期2-5,共4页
Samaranayake L. Commensal Oral Candida in Asian Cohorts. International Journal of Oral Science, 1 （1）： 2-5, 2009The oral carriage rate of Candida in healthy humans ranges from 40% to 60%. However for a prolonged pe... Samaranayake L. Commensal Oral Candida in Asian Cohorts. International Journal of Oral Science, 1 （1）： 2-5, 2009The oral carriage rate of Candida in healthy humans ranges from 40% to 60%. However for a prolonged period, the oral candidal prevalence in humans was documented essentially using data from studies in the West as their prevalence in inhabitants in different regions of the world,including Asia was not known. Yet, recent reports from a number of studies indicate the quality, quantity and prevalence of oral yeasts differ between Asia and other regions for reason that are still unclear. This mini review on such data from Asian studies on oral carriage of Candida provides another intriguing facet of the behavior of this ubiquitous yeast. 展开更多
关键词 Candida commensal oral Candida oralcandidal prevalence Asian cohorts
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Vulvovaginal Candidiasis: Profile of Antifungal Susceptibility Test of Candida Strains to Antifungal Drugs from 2018 to 2022, Ouagadougou, Burkina Faso 认领 引用
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作者 Essi Etonam Dovo Théodora Mahoukèdè Zohoncon +6 位作者 Pegdwendé Abel Sorgho Estelle Ouedraogo Mamadou Baduon Prudence Gouti Marius Belemgnegre Paul Ouedraogo Jacques Simpore 《Advances in Microbiology》 CAS 2025年第1期58-69,共12页
Background: Vulvovaginal candidiasis (VVC) is a common cause of significant morbidity, affecting millions of women worldwide. It is estimated that approximately 75%of women of childbearing age will have at least one e... Background: Vulvovaginal candidiasis (VVC) is a common cause of significant morbidity, affecting millions of women worldwide. It is estimated that approximately 75%of women of childbearing age will have at least one episode of candidiasis in their lifetime. In the last decades, resistance to azoles has become a public health problem. Although studies on vulvovaginitis have been done, there is lack of VVC studies in our area. The aim of this study was to describe the etiological and resistance profiles of vulvovaginal candidiasis to standard antifungus at the Saint Camille Hospital of Ouagadougou (HOSCO), Burkina Faso. Methods: We conducted a prospective study from January 2018 to December 2022. From vulvovaginal swabs, Candida species were identified using the ChromID® Candida Agar medium and the API® Candida gallery. Antifungal susceptibility testing was performed using Kirby-Bauer agar disk diffusion. Results: A total of 4789 women were sampled. The average age of sexually active women was 27.80+/−6.77 years, with extremes ranging from 15 to 64 years. Vaginal Candida infections accounted for 74.16% of the cases. The 20 - 29 age group was the most affected by vulvovaginal candidiasis. Pregnant women accounted for 28.76% of our study population. Women in the second (2nd) trimester of pregnancy had more Candida infections. Candida albicans was the most isolated species (55.12%), followed by Candida glabrata (27.64%), Candida tropicalis (6.91%), Candida famata (6.67%), Candida krusei (2.56%). All the Candida species isolated showed very high of resistance to Fluconazole (45.2%), Miconazole (23.7%) and Clotrimazole (45.7%). Conclusion: Species-specific antifungal results should always be considered to avoid antifungal resistance associated with vulvovaginal candidiasis. Identifying the causative species using vaginal fungal cultures can help guide therapy and improve outcomes for these patients. 展开更多
关键词 Vulvovaginal Candidiasis Candida albicans Azole Resistance Burkina Faso
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不同氮肥施用量下白符跳(Folsomia candida)对土壤微团聚体的影响 认领 引用
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作者 由乐林 张婷婷 +5 位作者 代文才 肖乃川 赵欢 张雅蓉 谢军 高明 《土壤学报》 CSCD 北大核心 2025年第4期1162-1173,共12页
阐明不同氮肥施用量下白符跳生长繁殖对土壤微团聚体的影响,可为改善土壤结构提供科学依据。采集田间试验不同氮肥施用量(N0:0 kg·hm-2、N90:90 kg·hm-2(以N计,下同)、N180:180 kg·hm-2、N270:270 kg·hm^(... 阐明不同氮肥施用量下白符跳生长繁殖对土壤微团聚体的影响,可为改善土壤结构提供科学依据。采集田间试验不同氮肥施用量(N0:0 kg·hm-2、N90:90 kg·hm-2(以N计,下同)、N180:180 kg·hm-2、N270:270 kg·hm-2、N360:360 kg·hm-2)的土壤进行培养试验,研究不同施氮处理土壤在不同培养周期(28 d、42 d、56 d)下白符跳的繁殖数、总体重差异及其对土壤微团聚体的影响。结果表明,不同氮肥施用量对土壤pH产生显著影响,N360处理较N0处理pH下降了0.9个单位(P<0.05)。随着培养周期的延长,白符跳的繁殖率随氮肥施用量增加受到显著的抑制作用,在56 d培养周期后,N0处理的繁殖数为其他处理的1.10倍~1.53倍(P<0.05)。白符跳总体重与繁殖数基本呈现相同的趋势,三个培养周期均在N360处理出现最低值。不同氮施用量处理下白符跳均能显著提升0.05~0.01 mm微团聚体的数量,相较于对照处理的土样提升11.3%~48.4%;同时显著降低2~0.25 mm小团聚体的数量,相较于未培养土壤降低了27.9%~60.9%(P<0.05)。各氮肥处理下土壤的平均重量直径和几何平均直径均显著低于未经过白符跳培养的土样(P<0.05)。可见,白符跳的生长繁殖受氮肥施用的抑制,高密度的白符跳可提升土壤微团聚体含量但破坏小团聚体,从而导致土壤的稳定性下降。 展开更多
关键词 氮肥用量 白符跳 繁殖 土壤微团聚体 密集效应
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阿特拉津降解真菌Candida tropicalis的分离鉴定与降解特性 认领 引用
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作者 于海玲 李妍 +3 位作者 王明元 彭汇涵 陈其煌 林永华 《亚热带农业研究》 2025年第3期145-153,共9页
[目的]筛选可以在南方湿热土壤环境中降解阿特拉津的真菌菌株,并了解其降解特性,以期为微生物修复阿特拉津污染土壤提供候选菌株。[方法]采用富集培养的方法,分离厦门市农田土壤中能够降解阿特拉津的菌株,并结合基因序列测定对其进行鉴... [目的]筛选可以在南方湿热土壤环境中降解阿特拉津的真菌菌株,并了解其降解特性,以期为微生物修复阿特拉津污染土壤提供候选菌株。[方法]采用富集培养的方法,分离厦门市农田土壤中能够降解阿特拉津的菌株,并结合基因序列测定对其进行鉴定;同时采用单因素试验法,研究不同环境条件(温度、pH、菌液接种量、阿特拉津初始浓度及碳源)对菌株降解特性的影响。[结果]经分离筛选得到1株降解菌AX1。该菌株呈圆形,边缘整齐、光滑,白色、不透明,无鞭毛。结合形态学特征和基因序列测定结果,菌株AX1被鉴定为热带假丝酵母菌(Candida tropicalis)。该菌株降解阿特拉津的最适温度为30℃,最适pH值范围为6~8,最适外加碳源为葡萄糖。在以上最适宜条件下培养72 h,对初始质量浓度为20 mg·L-1阿特拉津的降解率为49.67%,对50 mg·L-1阿特拉津的降解率为42.26%。[结论]从南方湿热土壤中分离的真菌菌株AX1能够降解阿特拉津,丰富了降解阿特拉津的微生物菌种资源。 展开更多
关键词 阿特拉津 热带假丝酵母菌 微生物降解 富集培养
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Inhibitory effects of Houttuynia cordata injection on hyphal growth and biofilm formation of Candida albicans 认领 引用
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作者 Qian-Wen Xu Ding-Hui Wang +2 位作者 Cang-Cang Zhang Da-Qiang Wu Xiao-Jia Niu 《Infectious Diseases Research》 2025年第1期28-34,共7页
Background:Houttuynia cordata injection(HCI),made from fresh Houttuynia cordata,exerts heat-clearing,detoxifying and diuretic effects.It is indicated for various infections including lung abscess,fever,leucorrhea,urin... Background:Houttuynia cordata injection(HCI),made from fresh Houttuynia cordata,exerts heat-clearing,detoxifying and diuretic effects.It is indicated for various infections including lung abscess,fever,leucorrhea,urinary tract infection and carbuncle.Candida albicans is a common opportunistic pathogen in immunocompromised individuals.This pathogenic fungus colonizes in skin,mucosa membrane and digestive tract,potentially progressing from localized mucosal infections to systemic disease.Methods:The minimum inhibitory concentration(MIC)of HCI against C.albicans strain was determined by the microdilution method.The hyphal status of C.albicans was observed after incubation in the liquid medium and evaluated by Gram staining.The biofilm formation ability was measured using XTT reduction assay and assessed by Calcofluor White staining.The expression of virulence-related genes was detected with quantitative RT-PCR.Results:The MIC of HCI against C.albicans strain was determined to be 0.5 g/mL.At this concentration,HCI exhibited inhibitory effects on hyphal formation,as confirmed by both liquid medium observation and Gram staining.HCI at the MIC also effectively inhibited C.albicans biofilm formation,which was verified through XTT reduction assay and Calcofluor White staining.Additionally,gene expression analysis revealed that HCI significantly suppressed the expression of virulence-related genes in C.albicans.Conclusion:HCI demonstrates inhibitory effects on C.albicans growth and biofilm development.It inhibits hyphal formation,affecting the yeast-to-hyphal transition.This study investigated the antifungal effects of HCI,providing potent experimental evidence for its mechanism of action against C.albicans. 展开更多
关键词 Houttuynia cordata injection Candida albicans mycelium virulence factors biofilms
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Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans 认领 引用 被引量：4
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作者 Ghaleb Adwan Yousef Salameh +1 位作者 Kamel Adwan Ali Barakat 《Asian Pacific Journal of Tropical Biomedicine》 CAS 2012年第5期375-379,共5页
Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.alb... Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.albicans) isolates.Methods:The antifungal activity of these toothpaste formulations was determined using a standard agar well diffusion method.Statistical analysis was performed using a statistical package,SPSS windows version 15,by applying mean values using one-way ANOVA with post-hoc least square differences(LSD) method.A P value of less than 0.05 was considered significant.Results:All toothpastes studied in our experiments were effective in inhibiting the growth of all C.albicans isolates.The highest anticandidal activity was obtained from toothpaste that containing both herbal extracts and sodium fluoride as active ingredients, while the lowest activity was obtained from toothpaste containing sodium monofluorophosphate as an active ingredient.Antifungal activity of Parodontax toothpaste showed a significant difference(P<0.001) against C.albicans isolates compared to toothpastes containing sodium fluoride or herbal products.Conclusions:In the present study,it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C.albicans,while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C.albicans.Some herbal toothpaste formulations studied in our experiments,appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products.Our results may provide invaluable information for dental professionals. 展开更多
关键词 Candida albicans Sodium fluoride Sodium monofluorophosphate Herbal toothpaste Conventional toothpaste Anticandidal activity Fluoride Oral cavity Herbel extract Plaque
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A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta L.leaf extract in vitro 认领 引用 被引量：4
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作者 Abu Arra Basma Zakaria Zuraini Sreenivasan Sasidharan 《Asian Pacific Journal of Tropical Biomedicine》 CAS 2011年第1期20-22,共3页
Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(E.hirta) L.leaf extract.Methods:Transmission electron microscopy was used to study t... Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(E.hirta) L.leaf extract.Methods:Transmission electron microscopy was used to study the ultrastructural changes caused by E.hirta extract on C. albicans cells al various exposure time.Results:It was found that the main abnormalities were the alterations in morphology,lysis and complete collapse of the yeast cells after 36 h of exposure to the extract.Whereas the control cultures showed a typical morphology of Candida with a uniform central density,typically structured nucleus,and a cytoplasm with several elements of endomembrane system and enveloped by a regular,intact cell wall.Conclusions:The significant antifungal activity shown by this methanol extract of E.hirta L.suggests its potential against infections caused by C.albicans.The extract may be developed as an anticandidal agent. 展开更多
关键词 Candida albicans Euphorbia hirta L. Transmission electron microscopy Anticandidal agent
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Candida endocarditis: Update on management considerations 认领 引用 被引量：2
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作者 Yasser Jamil Akintayo Akinleye +3 位作者 Mojtaba Mirzaei Matthew Lempel Kassem Farhat Samuel Pan 《World Journal of Cardiology》 2023年第10期469-478,共10页
The rise in incidence rates of invasive candidiasis warrants an increase in atten-tion and efforts toward preventing and treating this virulent infection.Cardiac involvement is one of the most feared sequelae and has ... The rise in incidence rates of invasive candidiasis warrants an increase in atten-tion and efforts toward preventing and treating this virulent infection.Cardiac involvement is one of the most feared sequelae and has a poor prognosis.Despite the introduction of several novel antifungal agents over the past quarter century,complications and mortality rates due to Candida endocarditis have remained high.Although fungal endocarditis has a mechanism similar to bacterial endocar-ditis,no specific diagnostic criteria or algorithm exists to help guide its manage-ment.Furthermore,recent data has questioned the current guidelines recommen-ding a combined approach of antifungal agents with surgical valve or indwelling prostheses removal.With the emergence of multidrug-resistant Candida auris,a focus on improved prophylactic measures and management strategies is nece-ssary. 展开更多
关键词 Candida Candida endocarditis Fungal endocarditis Invasive fungal infection
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