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Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols 认领 引用 被引量：1
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作者 Xianrong Zeng Hui-Ying Shi +1 位作者 Huiqian Huang Zhaobin Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期313-319,共7页
Synthesizing 2-deoxyglycosides,prevalent motifs in bioactive molecules,presents significant challenges in stereocontrol and functional group tolerance.We report a metal-free,photo-induced O-glycosylation of glycals us... Synthesizing 2-deoxyglycosides,prevalent motifs in bioactive molecules,presents significant challenges in stereocontrol and functional group tolerance.We report a metal-free,photo-induced O-glycosylation of glycals using acridinium salts under visible light.This method effectively couples diverse glycals with both carboxylic acids and alcohols,providing facile access to α-2-deoxyglycosides under mild conditions with broad substrate scope and functional group compatibility.The protocol exhibits highα-stereoselectivity with carboxylic acids and moderateα-selectivity with alcohols,enabling late-stage functionalization of complex molecules,including amino acids,peptides,and drugs.Mechanistic experiments implicate the possible involvement of radical intermediates,potentially operating via a chain reaction.Notably,2-deoxyglycosylation of NSAIDs using this method enhanced their neuroprotective properties in vitro.This photo-induced strategy offers a practical and versatile platform for accessing complex 2-deoxyglycans relevant to medicinal chemistry and chemical biology. 展开更多
关键词 2-Deoxyglycoside O-Glycosylation Carboxylic acids Alcohols Glycals
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Three-component synthesis of β-acyloxyl alkenyl amides for carboxylic acid/amino acid activation toward peptide and carboxylic acid derivatives synthesis 认领 引用
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作者 Dong-Fang Jiang Fei Zeng +1 位作者 Rong-Nan Yi Wei-Min He 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期1-2,共2页
The formation of peptide bonds is a crucial step in peptide synthesis and their long-term application across diverse fields.Therefore,identifying effective coupling reagents to activate carboxylic and amino acids rema... The formation of peptide bonds is a crucial step in peptide synthesis and their long-term application across diverse fields.Therefore,identifying effective coupling reagents to activate carboxylic and amino acids remains a central objective in peptide chemistry[1].Significant efforts have led to the discovery of numerous coupling agents,including both single-component and combined reagent systems.However,challenges such as high cost,limited commercial availability,un-desired racemization/epimerization,and potential safety hazards continue to hinder ideal peptide synthesis[2]. 展开更多
关键词 peptide synthesis amino acid activation formation peptide bonds activate carboxylic amino acids coupling agentsincluding acyloxyl alkenyl amides carboxylic acid activation coupling reagents
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Synergistic effect of oxygen vacancies and positively charged Ag clusters on Ag/CeO2 for efficient carboxylation of terminal alkynes with CO2 认领 引用
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作者 Jing Li Zhanwei Ma +4 位作者 Tingting Wang Chengli Song Qinsheng Zhang Xinyuan Mu Bin Hu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第2期569-578,I0013,共10页
The carboxylation of alkynes with CO2 has attracted considerable interest due to the valorization of C1resources and atomic economy.Much effort focused on active metals(e.g.,Au,Ag,Cu),while the mechanistic role of ... The carboxylation of alkynes with CO2 has attracted considerable interest due to the valorization of C1resources and atomic economy.Much effort focused on active metals(e.g.,Au,Ag,Cu),while the mechanistic role of active supports,particularly the oxygen vacancy(Ov),in modulating C-H bond carboxylation remains unknown.Herein,ultra-small silver clusters and morphologically engineered CeO2 support(nanorods,nanocubes,and nano particles)were employed to construct Ag cluster/Ov synergistic catalyst,which exhibits variations in Oy concentration by an in situ auto-reduction method.The 0.197%Ag/CeO2-NR catalyst exhibited a high reaction rate for the phenylacetylene carboxylation reaction and the maximal silver utilization efficiency.The characterization and DFT calculations demonstrated that vacancies enhanced CO2 adsorption via polarization-induced molecular bending and C-O bond elongation.Positively charged Ag clusters induced by metal-support interactions serve as deprotonation activation centers for alkynes.This synergistic interplay between dual active sites efficiently facilitates the C(sp)-H carboxylation with CO2.These findings offer critical insights for the rational selection of active supports in designing efficient C-H carboxylation catalysts. 展开更多
关键词 Carboxylation CO2 Terminal alkyne Oxygen vacancy Metal-support interaction
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Carboxylated Carbon Nanotube-Supported Copper-Indium Bimetallic Catalysts for Electroreduction of CO2 to Dimethyl Carbonate via Membrane-Free Cascade Electrosynthesis 认领 引用
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作者 Youjia Wang Xin Ma +4 位作者 Yuxin Tian Wenchao Wang Bochen Tian Yansheng Liu Junwei Hou 《Carbon and Hydrogen》 SCIE CAS CSCD 2026年第2期226-243,共18页
Under the background of the dual carbon strategy,upgrading CO2 electroreduction from C1 products to high-value C3 esters is an important direction for realizing its resource utilization and valorization.In this wor... Under the background of the dual carbon strategy,upgrading CO2 electroreduction from C1 products to high-value C3 esters is an important direction for realizing its resource utilization and valorization.In this work,Cu100In50 bimetallic catalysts supported on carboxylated carbon nanotubes were prepared,and a membrane-free paired electrolytic cell cascade system was constructed to achieve the directional conversion of CO2→CO→dimethyl carbonate(DMC).The catalyst exhibits enhanced CO supply and interfacial mass transfer capability,with the number of CO adsorption sites increased by 1.8 times and the methanol contact angle reduced from 22°to 8°.Electrochemical measurements show that the catalyst achieves a CO Faraday efficiency(FECO)of 60.9%at−1.8 V versus Ag/AgCl,whereas the FEH2 remains as low as 2.1%.In the cascade reaction,the FEDMC reaches 52.3%at−2.2 V and remains at 49.6%after 5 cycles.The system can also be extended to the electrosynthesis of diethyl carbonate(DEC),giving a FEDEC of 27.8%.In situ Raman spectroscopy combined with DFT calculations reveals that In doping shifts the d-band center of Cu by 0.38 eV,regulates the adsorption behavior of key intermediates,and suppresses HER,whereas carboxyl groups optimize the interfacial electronic structure and mass transfer behavior.This work provides an efficient catalytic strategy and mechanistic insight for the cascade valorization of CO2 into high-value carbonates. 展开更多
关键词 carboxylated carbon nanotubes cascade reaction CO2electroreduction copper-indium bimetallic catalyst DFT dimethyl carbonate insitu Raman spectroscopy
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Electrochemical C-H carboxylation of benzylamines 认领 引用
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作者 Weimei Zeng Youai Qiu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期290-295,共6页
In this study,electrochemical C-H carboxylation of benzylamines with CO2 was reported.This linear paired electrolysis system enables efficient and economical synthesis of value-added α-amino acids(α-AAs) under mi... In this study,electrochemical C-H carboxylation of benzylamines with CO2 was reported.This linear paired electrolysis system enables efficient and economical synthesis of value-added α-amino acids(α-AAs) under mild conditions.Various substituted benzylamines containing diverse functional groups and even highly reactive moieties,such as cyano,amide and alkene groups could be successfully transformed to the carboxylated products.Notably,this method proved to be applicable to the late-stage modification of biorelevant compounds,highlighting its potential for synthetic chemistry.Mechanistic studies such as radical trapping experiments,kinetic isotope effect(KIE) tests and cyclic voltammetry(CV) studies provided useful insight into this transformation. 展开更多
关键词 Electrochemical carboxylation Benzylic C-H bond Carbon dioxide α-Amino acids Linear paired electrolysis
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A novel process for precipitation of rare earths using carboxylic acid compounds 认领 引用 被引量：1
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作者 Yuhe Ran Ru'an Chi +4 位作者 Zhenyue Zhang Yuting Shi Wendou Chen Fei Long Hanjun Wu 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第1期311-321,共11页
Weathered rare earth ores are an important strategic mineral resource in China,and they are the primary source of medium and heavy rare earths(MHRE).The efficient recovery of MHRE is of great significance from an indu... Weathered rare earth ores are an important strategic mineral resource in China,and they are the primary source of medium and heavy rare earths(MHRE).The efficient recovery of MHRE is of great significance from an industrial standpoint.In this study,fulvic acid(FA) was employed as a precipitant to investigate the precipitation of rare earth(RE).The results indicate that the precipitation rates(w) of RE range from89.69 wt% to 99.86 wt% with the pH of 9,the molar ratio of 2,and the temperature of 40℃,except for Lu3+,the w reaches 97.33 wt% with the pH of 9,the molar ratio of 3,and the temperature of 25 ℃.The w of RE in the ammonium acetate rare earth leaching solution ranges from 95.99 wt% to 98.54 wt%,with the MH/L of the rare earth distribution after precipitation increasing from 0.77 to 0.80.The use of FA as a precipitant is demonstrated to yield effective precipitation of RE,particularly those of MHRE.FA complexes with RE3+,where deprotonation of COO-increases the surface electron density of oxygen atoms,creating additional active sites for electron-deficient RE3+.The mechanism provides a theoretical basis for using carboxylic acid compounds as new precipitants.Further,a novel technology for FA complexation precipitation of RE from lignite extract is proposed. 展开更多
关键词 Rare earths Weathered crust elution-deposited rare earth ores Rare earth precipitation Carboxylic acid rare earth precipitation
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Corrosion inhibition of AZ31 magnesium alloy in NaCl solution:Role of aromatic carboxylate molecular structures 认领 引用
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作者 Ci Song Bahram Vaghefinazari +4 位作者 Xiaosong Jia Yulong Wu Nico Scharnagl Mikhail L.Zheludkevich Sviatlana V.Lamaka 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2026年第4期259-278,共20页
The corrosion protection effect of aromatic carboxylates(benzoate,phthalate,isophthalate,terephthalate,1,2,4-benzoate,trimesate,and 1,2,4,5-benzenetetracarboxylate)in NaCl solution on AZ31 alloy has been investigated.... The corrosion protection effect of aromatic carboxylates(benzoate,phthalate,isophthalate,terephthalate,1,2,4-benzoate,trimesate,and 1,2,4,5-benzenetetracarboxylate)in NaCl solution on AZ31 alloy has been investigated.The results reveal that the inhibition mechanism is attributed to the effect of the studied molecules on the protective properties of a thin inhibitor-Mg(OH)2/MgO layer formed on the Mg surface.Both the number and position of carboxylate groups on the benzene ring influence the inhibition efficiencies of these inhibitors.A flat-lying molecular configuration more effectively shields the Mg surface from corrosive media.The findings confirm that the inhibitor-stabilized Mg(OH)2/MgO layer effectively blocks Cl−ingress and ensures strong corrosion protection for AZ31 alloy. 展开更多
关键词 Carboxylate Magnesium Corrosion inhibitor Trimesate Phthalate XPS
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A σ-π bond interchange assisted σ-π cross-metathesis reaction for nonoxidative conversion of methyl ketones to carboxylic acids 认领 引用
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作者 Huidan Geng Jiuwei Nie +6 位作者 Wei Chen Chong Zhao Zikun Yao Hui Wang Jiquan Zhang Lei Tang Yuanyong Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期478-486,共9页
Selective activation of C-C bonds via molecular editing is a fundamental challenge in organic synthesis.Among the various strategies,metathesis reactions have emerged as powerful tools for constructing new molecular a... Selective activation of C-C bonds via molecular editing is a fundamental challenge in organic synthesis.Among the various strategies,metathesis reactions have emerged as powerful tools for constructing new molecular architectures due to their well-established mechanisms.However,these reactions have largely been limited to the same types of covalent bonds,such asσ-σorπ-πbonds,leavingσ-πcross-metathesis reactions unexplored.Perhaps the bond redistribution between theσandπbonds is highly difficult due to the lack of p orbital inσbonds.Herein,we report the first example of a transition metal-freeσ-πcross-metathesis reaction that converts methyl ketones into the corresponding carboxylic acids along with the formation of 11H-benzo[b]fluoren-11-one.A comprehensive mechanistic investigation,supported by DFT calculations,was conducted to elucidate the unique reaction pathway.This study not only provides compelling evidence for the firstσ-πcross-metathesis reaction but also demonstrates the formation of a key oxetan-2-olate intermediate and its utility in organic transformations.This novel concept and strategy expand the scope of traditional metathesis reactions,offering new possibilities for selective C-C bond activation in a redox-neutral manner. 展开更多
关键词 Cross-metathesis reaction Nonoxidative Ketones to carboxylic acid Transition metal-free C-C bond activation
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Carbon–metal bond homolysis-recombination enabling enantioconvergent carboxylation with CO2:A theoretical study 认领 引用
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作者 Qi Zhou Cefei Zhang +6 位作者 Hui-Lin Luo Chuan-Xi Nie Changwei Hu Jian-Heng Ye Zhishan Su Li-Li Liao Da-Gang Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期270-276,共7页
The generation of transient radical species via carbon–metal bond homolysis is extremely useful,which can be harnessed to promote useful and selective radical-type transformations by the combination of transition met... The generation of transient radical species via carbon–metal bond homolysis is extremely useful,which can be harnessed to promote useful and selective radical-type transformations by the combination of transition metal catalysis.We herein establish a carbon–metal bond homolysisecombination model for the formation of enantiomerically enriched carbon-metal species,which accounts for the Ni-catalyzed enantioconvergent carboxylation of racemic benzyl ammonium salts with CO2.Theoretical studies suggest a distinct pathway involving a stereoinvertive nucleophilic substitution-type oxidative addition of racemic benzyl ammonium salts to Ni(0),forming a racemic benzyl Ni(Ⅱ)intermediate.Subsequent C–Ni bond homolysis of one enantiomer enables the formation of a transient radical,followed by a dynamic rotation along C–C·bond and radical recombination forming another more thermodynamically favored enantiomer.Geometry analysis suggests less H–H repulsion between the benzyl group and chiral ligand in the more stable isomer.After the reduction and stereoretentive inner-sphere nucleophilic attack on CO2process,the desired enantiomerically enriched carboxylic acid product is generated.ETS-NOCV analysis reveals a significant back-donation interaction between the dx2-y2 orbital of Ni atom and the unoccupied π* orbital of CO2 in inner-sphere transition state,thus effectively stabilizing the Ni–CO2 complex and facilitating subsequent C–C bond formation.The theoretical calculations provide critical insights into the systematic development of transition metal-catalyzed asymmetric carboxylation,highlighting significant potential for broad applications in synthetic organic chemistry. 展开更多
关键词 Enantioconvergent carboxylation Carbon-metal bond homolysis-recombination Transition metal catalysis DFT calculation Theoretical study
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Decoupling Stress Relief from Electrical Compromise via Carboxylated PMMA Nanospheres for Flexible Perovskite Solar Cells 认领 引用
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作者 Xiang-Jin Du Yu-Qi Cui +12 位作者 Shi-Yu Jiang Cheng-Yu Tan Chun-Jie Huang Xin-Ru Qin Rui Zhang Hong-Kun Wei Ying-Xin Ma Yi-Ming Li Hui-Jue Wu Jiang-Jian Shi Yan-Hong Luo Dong-Mei Li Qing-Bo Meng 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第7期150-155,I0131-I0143,共6页
Flexible perovskite solar cells(f-PSCs)hold great promise for next-generation wearable electronics,portable power sources and even space power systems.However,these applications are fundamentally limited by optoelectr... Flexible perovskite solar cells(f-PSCs)hold great promise for next-generation wearable electronics,portable power sources and even space power systems.However,these applications are fundamentally limited by optoelectronic degradation under mechanical strain.Although incorporating continuous polymeric networks enhances mechanical robustness,these insulating dielectric materials inevitably introduce carrier-transport barriers,leading to severe charge accumulation and a compromised fill factor(FF).Herein,we introduce 50-nm carboxyl-functionalized polymethyl methacrylate nanospheres(CPNs)to fundamentally decouple mechanical stress dissipation from interfacial carrier transport kinetics in inverted f-PSCs.Unlike continuous dielectric buffer layers,the CPNs self-assemble into a discontinuous nano-island network at the buried interface,maintaining unobstructed conductive pathways for efficient cross-interfacial charge transfer.Mechanically,the elastic nano-islands modulate the local strain field to efficiently dissipate mechanical and thermal stresses.Furthermore,the localized electrostatic field induced by the negatively charged carboxyl groups spatially repels electrons and accelerates hole extraction,profoundly suppressing non-radiative interfacial recombination.Consequently,the optimized f-PSCs achieve a power conversion efficiency exceeding 26%with a remarkably high FF of 0.845.The devices demonstrate outstanding structural and operational stability,exhibiting negligible degradation after 5,000 bending cycles at a 6-mm radius and retaining 96.3%of their initial efficiency after 200 thermal cycles(−60 to+80℃).This work provides a robust micromechanical and optoelectronic strategy for highly reliable flexible photovoltaics. 展开更多
关键词 power sources flexible perovskite solar cells f pscs hold carboxylated PMMA nanospheres electrical compromise insulating dielectric materials mechanical stress optoelectronic degradation polymeric networks
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Thermodynamic Correlation Between Surface Carboxyl Configuration and Wettability 认领 引用
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作者 GUO Zhuohuan WANG Dayang 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2026年第1期255-266,共12页
In this study,polyacrylic acid(PAA)films were employed as a model system,and a series of PAA films with tunable water wettability was systematically prepared by varying molecular weight and curing temperature.Using at... In this study,polyacrylic acid(PAA)films were employed as a model system,and a series of PAA films with tunable water wettability was systematically prepared by varying molecular weight and curing temperature.Using attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR),the molecular configurations of surface carboxyl groups(COOH),free carboxyl(COOHf)and hydrogen-bonded carboxyl(COOHHB,were directly correlated with the polar component of surface energy(γs,p).By decomposing theγs,pvalues of the PAA thin films as a sum of the contributions of COOHfand COOH_(H B),the intrinsic polar component of surface energy of COOH_(H B)(γ_(H B)s,p*)was quantified for the first time as 8.34 mN/m,significantly lower than that of COOHf(γfs,p*=34 mN/m).This result highlights that hydrogen bonding markedly reduces theγs,p,providing a rational explanation for the relatively large water contact angle observed on PAA thin films.Furthermore,it establishes a thermodynamic basis for estimating the fraction of surface COOH_(H B)groups(f H B)from wettability measurements.Further extension of the model to carboxyl-terminated self-assembled monolayers(COOH-SAMs)revealed that surface COOH density(ΣCOOH)critically regulates wetting behavior:whenΣCOOH ranges from 4.30 to 5.25 nm-2,COOH groups predominantly exist in a free state and facilitate effective hydration layers,thereby promoting superhydrophilicity.Overall,this study not only establishes a unified thermodynamic framework linking surface COOH configurations to macroscopic wettability,but also validates its universality by extending it to COOH-SAMs systems,thereby providing a unified theoretical framework for the controllable design of hydrophilicity in various COOH-functionalized surfaces. 展开更多
关键词 Polyacrylic acid film Hydrogen bonding Attenuated total reflectance Fourier-transform infrared spectroscopy Quantitative carboxyl configuration Polar component of surface energy
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Propanol as electron donor for efficient odd-chain carboxylate production by chain elongation with reactor microbiomes 认领 引用
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作者 Yanshen Zhang Bin Liu +2 位作者 Wanling Wu Haopeng Liu Wen Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第10期849-858,共10页
Microbial consortia that catalyze chain elongation processes have been enriched using different selection strategies,for which the electron donor is an essential one.Propanol is an extraordinarily promising electron d... Microbial consortia that catalyze chain elongation processes have been enriched using different selection strategies,for which the electron donor is an essential one.Propanol is an extraordinarily promising electron donor because it can be generated from renewable resources,including lignocellulosic biomass and protein wastes.Here,propanol was proven in detail to be an efficient electron donor,enhancing the production of odd medium-chain carboxylates during chain elongation.By exploring various electron acceptors,reactor conditions,and electron donor/electron acceptor mol ratios,our study highlights that acetate is the most suitable electron acceptor for the production of both odd-and even-chain carboxylates.The optimal conditions for propanol-based chain elongation were 30℃ and pH 6,achieving 82.8%selectivity for odd-chain carboxylates.Another critical insight from our work is that a propanol/acetate mol ratio of 1:1 can minimize the inhibitory effect of propanol and maximize the yield of medium-chain carboxylates,with the highest concentration of n-heptanoate reaching 124.5 mmol C/L.This was further illustrated by 16S rRNA amplicon sequencing,which elucidated that the community composition and keystone species in a propanol-based reactor closely resembled that of the ethanol one.The dominant phylum of the propanol-based reactor,Firmicutes showed a significant positive correlation with the concentrations of n-caproate and n-valerate.Additionally,the co-occurrence of Clostridium sensu stricto 12 and Oscillibacter,known as typical chain elongators,was identified within the propanol-based reactor.These findings enhance our understanding of propanolbased chain elongation,offer guiding principles for reactor microbiota assembly,and support efficient odd medium-chain carboxylate production. 展开更多
关键词 Propanol Microbial chain elongation Odd-chain carboxylates Carboxylate platform Anaerobic fermentation
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Copper-catalyzed and biphosphine ligand controlled3,4-boracarboxylation of 1,3-dienes with carbon dioxide 认领 引用
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作者 He Yao Wenhao Ji +6 位作者 Yi Feng Chunbo Qian Chengguang Yue Yue Wang Shouying Huang Mei-Yan Wang Xinbin Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第4期162-168,共7页
A strategy for copper-catalyzed and biphosphine ligand controlled boracarboxylation of 1,3-dienes and CO2 with 3,4-selectivity was developed.The Cu Cl coupled with DPPF(1,1-bis(diphenylphosphino)ferrocene)was assig... A strategy for copper-catalyzed and biphosphine ligand controlled boracarboxylation of 1,3-dienes and CO2 with 3,4-selectivity was developed.The Cu Cl coupled with DPPF(1,1-bis(diphenylphosphino)ferrocene)was assigned to be the best catalyst,with 84%yield and exclusive3,4-selectivity.The ligand effect on both catalytic activity and regioselectivity of boracarboxylation was disclosed,which is rarely reported in any copper catalyzed boracarboxylation.The borocupration process is revealed to be a vital step for the biphosphine participated boracarboxylation of 1,3-dienes with CO2.The minimal substrate distortion occurring in 3,4-borocupration favors the 3,4-regioselectivity of boracarboxylation.The“pocket”confinement and suitableβn(92°–106°)of bisphosphine ligands are demonstrated to be in favour of the interaction between LCu-Bpin complex(the catalytic precursor)and1,3-diene substrate to decrease their interaction energyΔEint(ζ)in 3,4-borocupration,thus promoting the 3,4-boracarboxylation. 展开更多
关键词 Carbon dioxide Ligand effect Carboxylation β γ-Unsaturated carboxylic acid DFT calculation
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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice 认领 引用 被引量：7
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作者 Zhengwei Hu Jing Yang +7 位作者 Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第1期253-264,共12页
The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed... The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s disease.We used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse brain.CHIP overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated tau.CHIP also alleviated the concentration of microglia and astrocytes around plaques.In APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin expression.Levels of HSP70 and HSP40,which have functional relevance to CHIP,were also increased.Single nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of CHIP.Our research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 mice.Indeed,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease. 展开更多
关键词 adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy
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Complexation and Fluorescence Enhancement of Bay-site Carboxyl Modified Perylene Dimide with Calcium Ion 认领 引用 被引量：3
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作者 GU Dandan ZHAO Haoru +4 位作者 JIANG Xiaoze QI Haohan LIAO Zuogui CHEN Jia SUN Bin 《发光学报》 EI CAS CSCD 北大核心 2025年第3期474-485,共12页
Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C12(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca2+)in THF/H2O soluti... Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C12(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca2+)in THF/H2O solution.The assembly and fluorescence behavior of PDI-COOH/Ca2+were studied in detail by changing hydration state with different concentrations.Based on the differences in assembly morphology and stoichiometric ratios of PDICOOH/Ca2+,we proposed the fluorescence emission mechanism of PDI-COOH/Ca2+in THF/H2O and THF,respectively.This work reveals a novel strategy of aggregated state fluorescence enhancement and reminds us of the important role of water in molecular fluorescence emission and assembly. 展开更多
关键词 carboxyl functionalized fluorescence behavior perylene diimide photoinduced electron transfer effect calcium ion
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Enhanced leaching of ionic rare earth ore facilitated by sodium alcohol ether carboxylate surfactant 认领 引用
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作者 Pengyu Lan Xianping Luo +2 位作者 Yongbing Zhang Peidi Luo Xuekun Tang 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第12期2789-2798,I0007,共10页
Surfactant sodium alcohol ether carboxylate(AEC-9Na)was added to the magnesium sulfate solution in order to enhance the leaching efficiency of ionic rare earth ore,and the mechanism of action for AEC-9Na was elucidate... Surfactant sodium alcohol ether carboxylate(AEC-9Na)was added to the magnesium sulfate solution in order to enhance the leaching efficiency of ionic rare earth ore,and the mechanism of action for AEC-9Na was elucidated.Under optimal conditions,the addition of AEC-9Na with a mass fraction of 0.03% can enhance the leaching rate by 5.2% and reduce the leaching cycle.Kinetic analysis demonstrates that the leaching process follows the model of internal diffusion control.The analysis of the mass transfer process reveals that the addition of AEC-9Na results in a decrease in the height equivalent to a theoretical plate(HETP)and an improvement in mass transfer efficiency.The addition of AEC-9Na can reduce the thickness of the water layer adsorbed on particles during leaching,which in turn reduces hydration and facilitates penetration of the leaching solution into ore body pores.This improves mass transfer concentration differences during leaching,and facilitates desorption of rare earth ions.Periodic density functional theory(DFT)calculations show that the adsorption of AEC-9Na onto the surface of kaolinite(001)enhances the hydrophilicity of the mineral surface and improves its permeability efficiency.Simultaneously,AEC-9Na forms complexes with hydrated rare earth ions on the kaolinite(001)surface,thereby reducing their adsorption strength on clay minerals.This promotes the exchange and desorption process of magnesium ions to hydrated rare earth ions,ultimately enhancing the mass transfer process for leaching rare earth elements. 展开更多
关键词 Ionic rare earth ore Sodium alcohol ether carboxylate Surfactant Mass transfer Seepage
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Up-flow anaerobic sludge blanket bioreactor for the production of carboxylates:effect of inocula on process performance and microbial communities 认领 引用
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作者 Adrián Lago Silvia Greses +1 位作者 Inés Moreno Cristina González-Fernández 《Bioresources and Bioprocessing》 SCIE EI CSCD 2025年第1期72-86,共15页
This research investigated the acidogenic fermentation(AF)of sugar cane molasses in an up-flow anaerobic sludge blanket(UASB)reactor for the production of carboxylates.The first step was to assess the optimum process ... This research investigated the acidogenic fermentation(AF)of sugar cane molasses in an up-flow anaerobic sludge blanket(UASB)reactor for the production of carboxylates.The first step was to assess the optimum process temperature(25,35 or 55℃)using two different granular inocula,one from a brewery company(BGS)and other from a paper plant company(PGS).These experiments determined that the most suitable temperature for carboxylates production was 25℃,obtaining higher bioconversions(27.3±0.3%using PGS and 39.2±0.2%using BGS),despite the low pH value recorded(4.0-4.2).Then,both inocula were tested in UASB reactors.As a consequence of the operational conditions(25℃,pH=5.5-6,organic loading rate(OLR)=3 gCOD·L-1·d-1 and hydraulic retention time(HRT)=10 d),the microbial communities changed from those typical for biogas production to those specialised in the production of volatile fatty acids(VFAs).Indeed,the highest bioconversion efficiency(70.1%)was obtained with BGS,where uncultured Eubacteriaceae family microorganisms(56.0%)prevailed,enhancing the production of butyric acid(59.5±2.4%w/w).Consequently,this inoculum was used to further identify the OLR threshold that should not be exceeded to attain optimal carboxylates production.OLR of 6 gCOD·L-1·d-1 resulted in a decrease in bioconversion efficiency(59.5%).The VFAs pool was dominated by butyric acid(63.0±1.4%w/w at an OLR of 4.5 gCOD·L-1·d-1 and 52.8±2.2%w/w at 6 gCOD·L-1·d-1).The microbial community became even more specialised,increasing the presence of Firmicutes and Actinobacteriota phyla,proving that the imposed conditions favoured the production of VFAs when operating semicontinuously fed UASB reactors. 展开更多
关键词 Anaerobic fermentation Sugar cane molasses Granular sludge Carboxylates
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TfOH-Catalyzed O-H Insertion of Carboxylic Acids with α-Aryl Diazoesters 认领 引用
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作者 Chen Guifang Li Hongqiang Zeng Xingrong 《有机化学》 SCIE CAS CSCD 北大核心 2025年第7期2537-2544,共8页
An efficient TfOH-catalyzed O—H insertion reaction of α-aryl diazoesters with carboxylic acids is reported.This metal-free protocol provides an operationally simple method for a one-pot assembly of diverse α-acylox... An efficient TfOH-catalyzed O—H insertion reaction of α-aryl diazoesters with carboxylic acids is reported.This metal-free protocol provides an operationally simple method for a one-pot assembly of diverse α-acyloxy esters in moderate to high yields with a broad substrate scope.All starting materials are readily available,and the reactions can be conducted in the open air at room temperature. 展开更多
关键词 carboxylic acids α-aryl diazoesters TfOH O-H insertion
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Influence of Polycarboxylate Superplasticizer on Rheological Behavior in Cement Paste 认领 引用 被引量：3
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作者 何燕 ZHANG Xiong +3 位作者 KONG Yaning WANG Xiaofu SHUI Liangliang WANG Haoren 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2018年第4期932-937,共6页
Molecular structures of polycarboxylate（PCE） superplasticizer significantly affect the rheological properties of cement paste. Consequently, we employed self-synthesized PCE copolymers with different carboxylic dens... Molecular structures of polycarboxylate（PCE） superplasticizer significantly affect the rheological properties of cement paste. Consequently, we employed self-synthesized PCE copolymers with different carboxylic densities to investigate their influence on the rheological behavior of cement paste. Three typical rheological models were applied to analyze the rheological properties, including Power-law model, Bingham model as well as Herschel-Buikley model. In addition, the thixotropical performances of cement paste in the presence of PCE with different carboxylic densities were investigated. The results show that the carboxylic density of PCE greatly influences the dispersing performance of PCE superplasticizers. As carboxylic density increases, the dispersing capability of PCE improves, and P（PEG1-AA6） possesses the strongest dispersing capability, the initial fluidity and 1 h fluidity of cement paste are both the highest, and cement paste has the lowest viscosity and the smallest hysteresis loop. 展开更多
关键词 polycarboxylate superplasticizer carboxylic density fluidity rheology thixotropy
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Stereoselective electrochemical carboxylation ofα,β-unsaturated sulfones 认领 引用 被引量：3
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作者 Zi-Xin Yang Liangchuan Lai +3 位作者 Jingze Chen Hong Yan Ke-Yin Ye Fen-Er Chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第6期315-318,共4页
As an attractive C1 synthon,carbon dioxide(CO2)has been extensively used in organic synthesis to produce carboxylic acids.In this research,stereoselective electrochemical carboxylation ofα,β-unsaturated sulfones ... As an attractive C1 synthon,carbon dioxide(CO2)has been extensively used in organic synthesis to produce carboxylic acids.In this research,stereoselective electrochemical carboxylation ofα,β-unsaturated sulfones has been developed under transition-metal-free conditions.All the cinnamic acids and the derivatives are obtained selectively in the E-configuration.Besides,arylpropiolates also can be produced from alkynyl sulfones. 展开更多
关键词 Electrosynthesis Carbon dioxide Carboxylation α β-Unsaturated sulfone α β-Unsaturated carboxylic acid
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