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Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function 认领 引用 被引量：1
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作者 Luyao Zhang Huan Tian +4 位作者 Yuanyuan Ma Jing Xu Chang Guo Zuomin Wang Jie Ma 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期115-125,共11页
Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microb... Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung. 展开更多
关键词 neutrophils chemotaxis pulmonary symptoms histopathology periodontitis neutrophils function chronic obstructive pulmonary disease respiratory function chronic obstructive pulmonary disease copd
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ADAM17 Supports Disinhibition of Pre-sympathetic Glutamatergic Neurons Through Microglial Chemotaxis 认领 引用
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作者 Jiawei Wang Zihan Qiu +12 位作者 Yue Han Hanxue Wu Miao Yuan Yan Liu Huichao Wang Shenglan Yuan Dengfeng Gao Lina Sun Xingjuan Chen Eric Lazartigues Fanni Li Rui Yang Jiaxi Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期189-209,共21页
A disintegrin and metalloprotease 17(ADAM17)is a membrane-bound enzyme that cleaves cell-surface proteins.Here,we discovered that neuronal ADAM17-mediated signaling supports the reduction of inhibitory presynaptic inp... A disintegrin and metalloprotease 17(ADAM17)is a membrane-bound enzyme that cleaves cell-surface proteins.Here,we discovered that neuronal ADAM17-mediated signaling supports the reduction of inhibitory presynaptic inputs to the pre-sympathetic glutamatergic neural hub,located in the paraventricular nucleus of the hypothalamus(PVN),upon stimulation by angiotensin II(Ang-II).For Ang-II-induced disinhibition,targeting microglial migration had an effect similar to ADAM17 knockout in glutamatergic neurons.Ang-II promoted neuron-mediated chemotaxis of microglia via neuronal CX3CL1 and ADAM17.Inhibiting microglial chemotaxis by targeting CX3CR1 abolished the Ang-II-induced microglial displacement of GABAergic presynaptic terminals and significantly blunted Ang-II’s pressor response.Using conditional and targeted knockout models of ADAM17,an increase in the contact between pre-sympathetic neurons and reactive microglia in the PVN was demonstrated to be neuronal ADAM17-dependent during the developmental stage of salt-sensitive hypertension.Collectively,this study provides evidence that neuronal ADAM17-mediated microglial chemotaxis facilitates the disinhibition of pre-sympathetic glutamatergic tone upon hormonal stimulation. 展开更多
关键词 ADAM17 Central nervous system AngiotensinⅡ Chemotaxis Salt-sensitive hypertension
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A Positivity-Preserving Fourier Spectral Moving Mesh Method for the Keller-Segel Chemotaxis Model 认领 引用
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作者 Yutong Kuang Zhiwen Zhang 《Communications in Mathematical Research》 CSCD 2026年第1期57-81,共25页
We develop a numerical method for the Keller-Segel chemotaxis system that is designed to(i)preserve the model’s fundamental structural properties(positivity/bound preservation,mass conservation,and energy dissipation... We develop a numerical method for the Keller-Segel chemotaxis system that is designed to(i)preserve the model’s fundamental structural properties(positivity/bound preservation,mass conservation,and energy dissipation),(ii)efficiently and accurately resolve the near-singular dynamics associated with spike formation and finite-time blow-up.Our approach combines a linear,positivity-preserving scalar auxiliary variable(SAV)scheme(following the framework in[15])with a Fourier spectral spatial discretization and an moving-mesh PDE-based method.The SAV reformulation provides a convenient platform for stable,linear time stepping while maintaining energy dissipation;the Fourier spectral discretization delivers high accuracy in smooth regions;and the moving-mesh PDE mesh redistribution concentrates collocation points in regions of large gradients so that sharp,localized structures can be resolved without prohibitive cost.We show that the proposed moving mesh SAV scheme inherits positivity preservation,mass conservation,and discrete energy dissipation provided the mesh motion avoids element overlap.Two-dimensional tests demonstrate the method’s ability to capture fine spike profiles and estimate blow-up times with substantially reduced computational effort;the formulation extends straightforwardly to three spatial dimensions.Numerical results show that the proposed method is a practical and effective method for accurate simulation of chemotactic aggregation. 展开更多
关键词 Keller-Segel chemotaxis model moving mesh PDE scalar auxiliary variable positivity preserving finite-time blowup
Improvement of Conditions for Global Boundedness in a Two-Competing-Species Chemotaxis Model with Indirect Signal Production 认领 引用
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作者 TENG Wenyi MIAO Liangying 《应用数学》 北大核心 2026年第2期457-465,共9页
This paper deals with the global boundedness of a two-competing-species chemotaxis model with indirect signal production in a three-dimensional bounded domain.The current work extends prior results by ZHENG et al.(202... This paper deals with the global boundedness of a two-competing-species chemotaxis model with indirect signal production in a three-dimensional bounded domain.The current work extends prior results by ZHENG et al.(2022)who established global existence and boundedness of classical solution under the parameter constraintsµ1µ2a2≥χ1(4+µ22a 22),µ1µ2a1≥χ2(4+µ12a1^( 2)).Our main contribution demonstrates that these technical conditions can be significantly relaxed toµ1≥5χ1,µ2≥5χ2,thereby expanding the admissible parameter space for solution boundedness. 展开更多
关键词 Two-competing-species Chemotaxis Indirect signal production Uniform boundedness
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Asymptotic Stability of Near-constant Steady States of the Chemotaxis Models in Symmetric Planar Domains 认领 引用
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作者 Wang Hongze 《数学理论与应用》 2026年第1期37-57,共21页
The stability of non-constant steady states in chemotaxis systems remains a challenging problem.In this paper,we employ local bifurcation theory to establish the existence of near-constant steady states in bounded pla... The stability of non-constant steady states in chemotaxis systems remains a challenging problem.In this paper,we employ local bifurcation theory to establish the existence of near-constant steady states in bounded planar domains.Building on the local bifurcation structure,together with asymptotic expansions of solutions and inequalities for Neumann eigenvalues,we investigate the asymptotic stability of these bifurcating steady states for the minimal model.In particular,we provide a detailed stability analysis for near-rectangular and near-disk planar domains with two axes of symmetry. 展开更多
关键词 Pattern formation;Bifurcation theory;Asymptotic stability;Chemotaxis model;Eigenvalue problem
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LEAP2 triggers retromer-mediated membrane trafficking of MOSPD2 to promote chemotaxis in teleost monocytes/macrophages 认领 引用
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作者 Ting-Fang Zhu Zi-Yue Zhao +4 位作者 Chen-Jie Fei Shi-Chang Shen Jian-Zhong Shao Li Nie Jiong Chen 《Zoological Research》 SCIE CAS CSCD 2025年第5期1153-1164,共12页
Liver-expressed antimicrobial peptide 2(LEAP2)is a key regulator of innate immune defense in teleosts,yet the molecular basis of its chemotactic function remains largely unidentified.Boleophthalmus pectinirostris MOSP... Liver-expressed antimicrobial peptide 2(LEAP2)is a key regulator of innate immune defense in teleosts,yet the molecular basis of its chemotactic function remains largely unidentified.Boleophthalmus pectinirostris MOSPD2(BpMOSPD2)was previously identified as a candidate receptor for BpLEAP2 in monocytes/macrophages(MO/MΦ).In the present study,BpLEAP2 stimulation was found to trigger a retromer-dependent intracellular trafficking program essential for BpMOSPD2-mediated chemotaxis.Exposure to BpLEAP2 significantly enhanced BpMO/MΦmigration and promoted the accumulation of BpMOSPD2 at the plasma membrane.Subcellular fractionation and immunofluorescence analyses revealed that BpMOSPD2 translocated from the endoplasmic reticulum(ER)to early endosomes upon BpLEAP2 stimulation,followed by redistribution to the cell surface.Blockade of ER export or knockdown of core retromer subunits(BpVPS35,BpVPS26,or BpVPS29)abolished membrane localization and attenuated BpLEAP2-induced migration.Co-immunoprecipitation combined with mass spectrometry confirmed direct binding between BpMOSPD2 and BpVPS35,while domain-mapping indicated that this interaction was not exclusively dependent on MSP or CRAL-TRIO domains.Depletion of individual retromer components led to retention of BpMOSPD2 in early endosomes,establishing the necessity of the retromer complex for receptor recycling.Functionally,disruption of this complex eliminated the pro-migratory activity of BpLEAP2 on BpMO/MΦ.These findings identify the retromer complex as a critical regulator of BpMOSPD2 trafficking and uncover a previously unrecognized mechanism through which BpLEAP2 promotes MO/MΦmigration in teleosts. 展开更多
关键词 LEAP2 MOSPD2 Retromer complex Membrane trafficking Chemotaxis
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Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans 认领 引用 被引量：5
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作者 XING Xiaojuan DU Min +1 位作者 ZHANG Yanfen WANG Dayong 《Journal of Environmental Sciences》 SCIE EI CAS 2009年第12期1684-1694,共11页
Chemotaxis to water-soluble attractants is mainly controlled by ASE sensory neuron whose specification is regulated by che-1 in Caenorhabditis elegans.Our data suggested that exposure to high concentrations of metals,... Chemotaxis to water-soluble attractants is mainly controlled by ASE sensory neuron whose specification is regulated by che-1 in Caenorhabditis elegans.Our data suggested that exposure to high concentrations of metals,such as Pb,Cu,Ag,and Cr,would result in severe defects of chemotaxis to water-soluble attractants of NaCl,cAMP,and biotin.Moreover,the morphology of ASE neuron structures as observed by relative fluorescent intensities and relative size of fluorescent puncta of cell bodies,relative lengths of sensory endings in ASE neurons,and the expression patterns of che-1 were obviously altered in metal exposed animals when they meanwhile exhibited obvious chemotaxis defects to water-soluble attractants.In addition,the dendrite morphology could be noticeably changed in animals exposed to 150μmol/L of Pb,Cu,and Ag.Furthermore,we observed significant decreases of chemotaxis to water-soluble attractants in Pb exposed che-1 mutant at concentrations more than 2.5μmol/L,and in Cu,Ag,and Cr exposed che-1 mutant at concentrations more than 50μmol/L.Therefore,impairment of the ASE neuron structures and functions may largely contribute to the appearance of chemotaxis defects to water-soluble attractants in metal exposed nematodes. 展开更多
关键词 chemotaxis water-soluble attractant ASE neuron che-1 Caenorhabditis elegans
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Metabolism-independent chemotaxis of Pseudomonas sp. strain WBC-3 toward aromatic compounds 认领 引用 被引量：3
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作者 ZHANG, Junjie XIN, Yufeng +2 位作者 LIU, Hong WANG, Shujun ZHOU, Ningyi 《Journal of Environmental Sciences》 SCIE EI CAS 2008年第10期1238-1242,共5页
Pseudomonas sp. strain WBC-3 utilized methyl parathion or para-nitrophenol (PNP) as the sole source of carbon, nitrogen, and energy, and methyl parathion hydrolase had been previously characterized. Its chemotactic be... Pseudomonas sp. strain WBC-3 utilized methyl parathion or para-nitrophenol (PNP) as the sole source of carbon, nitrogen, and energy, and methyl parathion hydrolase had been previously characterized. Its chemotactic behaviors to aromatics were investigated. The results indicated that strain WBC-3 was attracted to multiple aromatic compounds, including metabolizable or transformable substrates PNP, 4-nitrocatechol, and hydroquinone. Disruption of PNP catabolic genes had no e?ect on its chemotactic behaviors w... 展开更多
关键词 aromatics chemotaxis metabolism-independent methyl parathion nitrophenol Pseudomonas sp. strain WBC-3
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SOLVABILITY OF A PARABOLIC-HYPERBOLIC TYPE CHEMOTAXIS SYSTEM IN 1-DIMENSIONAL DOMAIN 认领 引用 被引量：6
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作者 陈化 吕文斌 吴少华 《Acta Mathematica Scientia》 SCIE CSCD 2016年第5期1285-1304,共20页
In this paper, we use contraction mapping principle, operator-theoretic approach and some uniform estimates to establish local solvability of the parabolic-hyperbolic type chemotaxis system with fixed boundary in 1-di... In this paper, we use contraction mapping principle, operator-theoretic approach and some uniform estimates to establish local solvability of the parabolic-hyperbolic type chemotaxis system with fixed boundary in 1-dimensional domain. In addition, local solvability of the free boundary problem is considered by straightening the free boundary. 展开更多
关键词 parabolic-hyperbolic system free boundary chemotaxis model local existence
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Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis defects by microcystin-LR exposure in nematode Caenorhabditis elegans 认领 引用 被引量：2
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作者 LI Yunhui YE Huayue +4 位作者 DU Min ZHANG Yanfen YE Boping PU Yuepu WANG Dayong 《Journal of Environmental Sciences》 SCIE EI CAS 2009年第7期971-979,共9页
Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin （MC）-LR also could cause neurotoxicity. Nematode Caenorhabditis elegans was explored as a model to study the neurotoxicity. In the presen... Apart from the liver disruption, embryotoxicity and genotoxicity, microcystin （MC）-LR also could cause neurotoxicity. Nematode Caenorhabditis elegans was explored as a model to study the neurotoxicity. In the present study, we provided evidence to indicate the neurotoxicity on chemotaxis to NaCl and diacetyl, and thermotaxis from MC-LR exposure to C. elegans. As a result, higher concentrations of MC-LR caused significantly severe defects of chemotaxis to NaCl and diacetyl, and thermotaxis. The neurotoxicity on chemotaxis to NaCl and diacetyl, and thermotaxis from MC-LR exposure might be largely mediated by the damage on the corresponding sensory neurons （ASE, AWA, and AFD） and interneuron AIY. The expression levels ofche-1 and odr-7 were significantly decreased （P 〈 0.01） in animals exposed to MC-LR at concentrations lower than 10 μg/L, whereas the expression levels of ttx-1 and ttx-3 could be significantly （P 〈 0.01） lowered in animals even exposed to 1 μg/L of MC-LR. Moreover, both the chemotaxis to NaCl and diacetyl and the thermotaxis were more significantly reduced in MC-LR exposed mutants of che-1（p674）, odr-7（ky4）, ttx-1（p767）, and ttx-3（ks5） than those in exposed wild-type N2 animals at the same concentrations. 展开更多
关键词 MC-LR chemotaxis thermotaxis neurotoxicity Caenorhabditis elegans
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Construction and Expression of Eukaryotic Expressing Vector pCH510 of Polypeptide CH50 and Its Chemotaxis and Antitumor Function by in vivo Transfection 认领 引用 被引量：5
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作者 李东 冯作化 +4 位作者 叶仕桥 张桂梅 张慧 黄波 肖徽 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2001年第1期1-5,共5页
To construct an eukaryotic expressing vector that expresses CH50, a recombinant CellⅠ HepⅡ bifunctional domain polypeptide of human fibronectin, and to investigate the chemotaxis to immune cells and the inhibitory e... To construct an eukaryotic expressing vector that expresses CH50, a recombinant CellⅠ HepⅡ bifunctional domain polypeptide of human fibronectin, and to investigate the chemotaxis to immune cells and the inhibitory effect on the growth of tumor by the expression of the plasmid in vivo , the plasmid was constructed by DNA recombination. Gene transfection was performed in vitro and in vivo . The expressed product was identified by Western blot. The chemotaxis after gene transfection in vivo was observed by histotomy and staining of muscle tissues. The inhibition of gene transfection on solid tumor was observed in mice. The results showed that plasmid pCH510 was constructed by the recombination of the 5′ terminal noncoding region and signal peptide coding region of human fibronectin cDNA and cDNA fragment coding CH50 polypeptide with a 3′ terminal noncoding region of human FN cDNA, and the insertion of the recombinated fragment into plasmid pcDNA3.1. After transfection with plasmid pCH510, NIH3T3 cells could produce CH50 polypeptide. The transfection of plasmid pCH510 by the injection in muscle of mouse could produce the effects of chemotaxis on immune cells and the inhibition on the growth of solid tumor. It is concluded that plasmid pCH510 can express in cells and in vivo in mouse. The expression of the plasmid in vivo has a chemotactic effect on immune cells and can inhibit the growth of solid tumor. 展开更多
关键词 fibronectin recombinant polypeptide chemotaxis tumor
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Expression of Metadherin/AEG-1 Gene Is Positively Related to Orientation Chemotaxis and Adhesion of Human Hepatocellular Carcinoma Cell Lines of Different Metastatic Potentials 认领 引用 被引量：9
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作者 周珍珍 邓欢 +4 位作者 晏维 黄焕军 邓玥灵 黎媛 田德安 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2012年第3期353-357,共5页
Metastasis contributes to the poor prognosis of hepatocellular carcinoma （HCC）. However, the mechanism through which a primary HCC cell develops into a metastatic phenotype is not well understood. The purpose of thi... Metastasis contributes to the poor prognosis of hepatocellular carcinoma （HCC）. However, the mechanism through which a primary HCC cell develops into a metastatic phenotype is not well understood. The purpose of this study was to examine the correlation between metadherin （MTDH）/ astrocyte elevated gene-1 （AEG-1） expression in HCC cell lines of different metastatic potentials and such metastatic phenotypes as orientation chemotaxis and adhesion. MTDH/AEG-1 expression was detected by RT-PCR and western blotting in HCC cell lines （HepG2, Huh7, Sk-HEP-1, MHCC-97H）. Distribution of MTDH/AEG-1 was observed by immunofluorescence staining and confocal laser scanning microscopy. The abilities of orientation chemotaxis and adhesion and the index of interaction between HCC cell lines and microvascular endothelial cell lines （MVECs, including HUVECs and HPMECs） were measured by chemotaxis assay and adhesion assay, respectively. The results showed that MTDH/AEG-1 protein expression was significantly higher in high metastatic potential cancer cell lines （Sk-HEP-1, MHCC-97H ） than in low metastatic potential cell lines （HepG2, Huh7） （P〈0.05）. The MTDH/AEG-1 protein was localized in the perinuclear region of HCC cells. Furthermore, the abilities of orientation chemotaxis and adhesion of HCC cells to HPMECs were increased as compared with those of HCC cells to HUVECs （P〈0.05）. The abilities of orientation chemotaxis and adhesion were much stronger in Sk-HEP-1 and MHCC-97H cells with MTDH/AEG-1 highly expressed than in HepG2 and Huh7 cells with MTDH/AEG-1 lowly expressed （P〈0.05）. These results suggested that the expression of MTDH/AEG-1 gene in HCC cell lines of different metastatic potentials was closely positively related to the abilities of orientation chemotaxis and adhesion of HCC cells. It was deduced that MTDH/AEG-1 might play a pivotal role in the lung-specific metastasis of HCC, which may be medi-ated through orientation chemotaxis and adhesion abilities of HCC cells. MTDH/AEG-1 may serve as a potential therapeutic target for HCC. 展开更多
关键词 carcinoma hepatocellular MTDH/AEG-1 metastasis chemotaxis adhesion
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BOUNDEDNESS AND ASYMPTOTIC STABILITY IN A PREDATOR-PREY CHEMOTAXIS SYSTEM WITH INDIRECT PURSUIT-EVASION DYNAMICS 认领 引用 被引量：2
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作者 Shuyan QIU Chunlai MU Hong YI 《Acta Mathematica Scientia》 SCIE CSCD 2022年第3期1035-1057,共23页
This work explores the predator-prey chemotaxis system with two chemicals {ut = Δu + ∇ ・ (u∇v) + μ1u(1 − u − α1w), x ∈ Ω, t > 0,v_(t )= Δv −α1v + β1w, x ∈ Ω, t > 0,wt = Δw − ξ∇ ・ (w... This work explores the predator-prey chemotaxis system with two chemicals {ut = Δu + ∇ ・ (u∇v) + μ1u(1 − u − α1w), x ∈ Ω, t > 0,v_(t )= Δv −α1v + β1w, x ∈ Ω, t > 0,wt = Δw − ξ∇ ・ (w∇z) + μ2w(1 + α2u − w), x ∈ Ω, t > 0,zt =Δz −α2z +β2u, x ∈ Ω, t > 0, in an arbitrary smooth bounded domainΩ■Rn under homogeneous Neumann boundary conditions.The parameters in the system are positive.We first prove that if n≤3,the corresponding initial-boundary value problem admits a unique global bounded classical solution,under the assumption thatχ,ξ,μi,ai,αi andβi(i=1,2)satisfy some suitable conditions.Subsequently,we also analyse the asymptotic behavior of solutions to the above system and show that·when a11 andμ2/ξ2 is sufficiently large,the global bounded classical solution(u,v,w,z)of this system exponentially converges to(0,α1/β1,1,0)as t→∞;·when a1=1 andμ2/ξ2 is sufficiently large,the global bounded classical solution(u,v,w,z)of this system polynomially converges to(0,α1/β1,1,0)as t→∞. 展开更多
关键词 Chemotaxis predator-prey boundedness stabilization
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THE SINGULAR CONVERGENCE OF A CHEMOTAXIS-FLUID SYSTEM MODELING CORAL FERTILIZATION 认领 引用 被引量：1
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作者 杨明华 孙晋易 +1 位作者 傅尊伟 王政 《Acta Mathematica Scientia》 SCIE CSCD 2023年第2期492-504,共13页
The singular convergence of a chemotaxis-fluid system modeling coral fertilization is justified in spatial dimension three.More precisely,it is shown that a solution of parabolic-parabolic type chemotaxis-fluid system... The singular convergence of a chemotaxis-fluid system modeling coral fertilization is justified in spatial dimension three.More precisely,it is shown that a solution of parabolic-parabolic type chemotaxis-fluid system modeling coral fertilization■converges to that of the parabolic-elliptic type chemotaxis-fluid system modeling coral fertiliz ation■in a certain Fourier-Herz space asε-1→0. 展开更多
关键词 chemotaxis singular convergence recation diffusion Fourier-Herz space
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Swimming Behavior Analysis Based on Bacterial Chemotaxis in Solution 认领 引用 被引量：1
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作者 Bin He Zhipeng Wang +2 位作者 Chaoqun Liu Yonggang Li Runjie Shen 《Journal of Bionic Engineering》 SCIE EI CSCD 2012年第3期315-321,共7页
Microrobots is playing more and more important roles for medical applications, such as targeting tumoral lesions for therapeutic purposes, Minimally Invasive Surgery （MIS） and highly localized drug delivery. However... Microrobots is playing more and more important roles for medical applications, such as targeting tumoral lesions for therapeutic purposes, Minimally Invasive Surgery （MIS） and highly localized drug delivery. However, energy efficient pro- pulsion system poses significant challenges for the implementation of such mobile robots. Flagellated chemotactic bacteria can be used as an effective integrated propulsion system for microrobots. In this paper, we proposed a new type of propulsion method that is inspired by the motility mechanism of flagellated chemotactic bacteria in different pH gradients. The pH gradient field was established in solution through electrolysis method. The distribution of the pH values in solution was measured with pH indicator and analyzed with image processing technology, and the mechanism by which the pH values changed was also discussed. The swimming speed and direction of the bacteria were studied experimentally. Through analyzing the key pa- rameters, such as stabilization time and electrode voltage, the optimal design of propulsion mechanism based on bacteria motion in the pH gradient field was proven. 展开更多
关键词 microrobots bacteria drive pH gradient chemotaxis
GLOBALLY BOUNDED IN-TIME SOLUTIONS TO A PARABOLIC-ELLIPTIC SYSTEM MODELLING CHEMOTAXIS 认领 引用 被引量：4
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作者 钟新华 江松 《Acta Mathematica Scientia》 SCIE 2007年第2期421-429,共9页
In this article, the globally bounded in-time pointwise estimate of solutions to the simplified Keller-Segel system modelling chemotaxis are derived. Moreover, a local existence theorem is obtained.
关键词 Keller-Segel system chemotaxis globally bounded
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THE LOCAL WELL-POSEDNESS OF A CHEMOTAXIS-SHALLOW WATER SYSTEM WITH VACUUM 认领 引用 被引量：1
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作者 Jishan FAN Fucai LI Gen NAKAMURA 《Acta Mathematica Scientia》 SCIE CSCD 2021年第1期231-240,共10页
In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R2without the standard compatibility condition for the initial data... In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R2without the standard compatibility condition for the initial data.This improves some results obtained in[J.Differential Equations 261(2016),6758-6789]. 展开更多
关键词 chemotaxis shallow water vacuum local well-posedness strong solution
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Signaling mechanisms for regulation of chemotaxis 认领 引用 被引量：4
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作者 DianqingWU 《Cell Research》 SCIE CAS 2005年第1期52-56,共5页
Chemotaxis is a fascinating biological process, through which a cell migrates along a shallow chemoattractant gradient that is less than 5% difference between the anterior and posterior of the cell. Chemotaxis is comp... Chemotaxis is a fascinating biological process, through which a cell migrates along a shallow chemoattractant gradient that is less than 5% difference between the anterior and posterior of the cell. Chemotaxis is composed of two independent, but interrelated processes-motility and directionality, both of which are regulated by extracellular stimuli, chemoattractants. In this mini-review, recent progresses in the understanding of the regulation of leukocyte chemotaxis by chemoattractant signaling are reviewed. 展开更多
关键词 chemotaxis leukocyte signaling chemoattractant.
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Integrin betal mediates hepatocellular carcinoma cells chemotaxis to laminin 认领 引用 被引量：4
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作者 Bian-Hong Fu, Ze-Zhi Wu and Cheng Dong Chongqing, China College of Bioengineering, Key Lab for Biomechanics and Tissue Engineering under the State Ministry of Education and College of Resources & Environmental Science , Chongqing University, Chongqing 400044, China Bioengineering Pro- gram, Pennsylvania State University, 205 Hallowell Building, University Park, Pennsylvania 16802-6804, USA 《Hepatobiliary & Pancreatic Diseases International》 CAS 2004年第4期548-551,共4页
BACKGROUND: Chemotaxis is an important step durin the invasion of carcinoma cells. And integrins are most im portant receptors mediating interaction between cells an extracellular matrix ( ECM). This study was designe... BACKGROUND: Chemotaxis is an important step durin the invasion of carcinoma cells. And integrins are most im portant receptors mediating interaction between cells an extracellular matrix ( ECM). This study was designed t study integrin betal mediating chemotaxis of hepatocellula carcinoma (HCC) cells to laminin (LN). METHODS: A micropipette technique was adopted to in vestigate the effect of blockade of integrin betal on pseudo pod protrusion of HCC cells in response to LN stimulation Chemotactic pseudopod protrusion of a HCC cell was eva luated using a dual-pipette set-up, in which two pipette filled with LN solution were positioned in close contact wit the same cell, and pseudopod protrusion into each pipett was viewed dynamically and recorded with a tape recorder The lengths of pseudopods were measured and plotte against time to obtain a pseudopod growth curve. The in tegrin betal subunit on the surfaces of HCC cells were ana lyzed by flow cytometry. RESULTS: In dual pipette chemotaxis experiment, whe the two pipettes were filled with LN(50 μg/ml, 200 μg/ml) pseudopods extended from the HCC cell into each of th pipettes nearly symmetrically, ie, with nearly identica maximum pseudopod length and similar pseudopod growth curves. Upon addition of anti-CD29 (20 μg/ml) to one o the pipettes, pseudopod protrusion was blocked nearly completely while protrusion into the opposite pipette be came more evidently, with a larger maximum length. Ex pression of integrin betal was up to 95.78% to cells chosen in the experiment. CONCLUSION: Integrin betal subunit was an importan constituent receptor subunit for mediating chemotactic pseudopod protrusion of HCC cell to LN. 展开更多
关键词 hepatocellular carcinoma integrins laminin chemotaxis micropipette aspiration technique
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GLOBAL ATTRACTOR FOR A DENSITY-DEPENDENT SENSITIVITY CHEMOTAXIS MODEL 认领 引用 被引量：1
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作者 陈学勇 刘伟安 《Acta Mathematica Scientia》 SCIE CSCD 2012年第4期1365-1375,共11页
In this paper, a chemotaxis model with reproduction term in a bounded domain Ω R^n is discussed. The existence of a global-in-time solution and a global attractor for this model are obtained.
关键词 chemotaxis global existence global attractor
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